ifenprodil and glutamic acid

ifenprodil has been researched along with glutamic acid in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (35.19)	18.2507
2000's	23 (42.59)	29.6817
2010's	10 (18.52)	24.3611
2020's	2 (3.70)	2.80

Authors

Authors	Studies
Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA	1
Darles, G; Graham, D; Langer, SZ	1
Meguri, H; Ogita, K; Ohgaki, T; Ohkawara, A; Suzuki, T; Uchida, S; Yoneda, Y	1
Canton, H; Colpaert, F; Lehmann, J	1
Ransom, RW	1
Kerby, J; Laughton, P; Le Bourdellés, B; Myers, J; Priestley, T; Whiting, PJ	1
Williams, K	1
Baudry, M; Marvizón, JC	1
Akaike, A; Sasa, M; Sato, Y; Takaori, S; Tamura, Y; Yokota, T	1
Lu, L; Luo, J; McGonigle, P; Munir, M; Wang, YH; Wolfe, BB	1
Chavez-Noriega, L; Crona, J; Daggett, LP; Deal, C; Ellis, SB; Hess, SD; Johnson, EC; Lu, CC; Urrutia, A; Veliçelebi, G	1
Kemp, JA; Kew, JN; Trube, G	2
Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M	1
Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G	1
Antonelli, T; Beani, L; Bianchi, C; Reggiani, A; Tomasini, MC; Trist, DG	1
Aizenman, E; Brimecombe, JC; Gallagher, MJ; Lynch, DR	1
Bonn, G; Fiechtner, B; Glossmann, H; Huck, CW; Moebius, FF; Soellner, KE	1
Abdrachmanova, G; Palecek, JI; Vlachová, V; Vyklick, L	1
Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS	1
Gottmann, K; Hatt, H; Mohrmann, R	1
Akaike, A; Honda, Y; Kaneda, K; Kashii, S; Kikuchi, M; Sato, S; Yasuyoshi, H; Zhang, S	1
Banke, T; Conn, PJ; Erreger, K; Lee, CJ; Low, CM; Traynelis, SF; Zheng, F	1
Kazuta, Y; Kohsaka, S; Kudo, Y; Matsuda, A; Mishina, M; Nakajima-Iijima, S; Nakamura, T; Shuto, S; Uchino, S; Watanabe, W	1
Cunningham, MO; Evans, DI; Jones, RS; Woodhall, G	1
Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C	1
Bading, H; Fukunaga, Y; Hardingham, GE	1
Gottmann, K; Hatt, H; Köhr, G; Mohrmann, R; Sprengel, R	1
Alhonen, L; Gröhn, OH; Jänne, J; Kaasinen, SK; Keinänen, TA	1
Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA	1
Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR	1
Bale, AS; Carpenter-Hyland, EP; Chandler, LJ; Tu, Y; Woodward, JJ	1
Bednar, B; Bednar, RA; Bennett, PB; Cheng, G; Kane, SA; Kiss, L; Koblan, KS; McCauley, JA; McIntyre, CJ	1
Shuaib, A; Wang, CX	1
Miyatake, M; Nakamura, A; Narita, M; Shibasaki, M; Suzuki, T	1
Gogas, KR	1
Cordeiro, MF; Fitzke, FW; Guo, L; Luong, V; Maass, A; Moss, SE; Salt, TE	1
Bergersen, LH; Bezzi, P; Bhaukaurally, K; Domercq, M; Gundersen, V; Jourdain, P; Matute, C; Santello, M; Tonello, F; Volterra, A	1
Birgner, C; Elfverson, M; Frändberg, PA; Johansson, T; Le Grevès, P; Nyberg, F	1
Bellone, C; Nicoll, RA	1
Acher, F; Alarcon, K; Bertrand, HO; Krzaczkowski, L; Le Goff, A; Leonetti, M; Mony, L; Neyton, J; Paoletti, P	1
Gavazzo, P; Guida, P; Marchetti, C; Zanardi, I	1
Cais, O; Dittert, I; Korinek, M; Sedlacek, M; Vyklicky, L	1
Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS	1
Cunha, RA; Musante, V; Pittaluga, A; Raiteri, M; Summa, M	1
Bendová, Z; Sládek, M; Svobodová, I	1
Amico-Ruvio, SA; Myers, JM; Paganelli, MA; Popescu, GK	1
Balayssac, D; Bayet-Robert, M; Daulhac, L; Eschalier, A; Ferrier, J; Moulinoux, JP; Pereira, B; Pezet, D	1
Hansen, KB; Ogden, KK; Traynelis, SF; Yuan, H	1
Bozsó, Z; Fülöp, L; Juhász, G; Penke, B; Szegedi, V; Varga, E	1
Galvin, C; Lee, FS; Ninan, I	1
Antic, SD; Oikonomou, KD; Rich, MT; Short, SM; Singh, MB	1
Foster Olive, M; Gipson, CD; Leyrer-Jackson, JM; McCallum, J; Piña, JA	1
Hou, YJ; Mi, QJ; Ni, QB; Sun, BL; Sun, JY; Wang, HB; Yang, MF; Yuan, H; Zhang, ZY; Zhao, SJ	1

Reviews

2 review(s) available for ifenprodil and glutamic acid

Article	Year
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:2 Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamate; Glutamic Acid; Humans; Neuroprotective Agents; Phenylcarbamates; Piperidines; Propylene Glycols; Protein Conformation; Rats; Receptors, N-Methyl-D-Aspartate	2005
Glutamate-based therapeutic approaches: NR2B receptor antagonists. Current opinion in pharmacology, 2006, Volume: 6, Issue:1 Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Huntington Disease; Pain; Phenols; Piperidines; Protein Conformation; Receptors, N-Methyl-D-Aspartate	2006

Article

Year

NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.

Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:2

Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamate; Glutamic Acid; Humans; Neuroprotective Agents; Phenylcarbamates; Piperidines; Propylene Glycols; Protein Conformation; Rats; Receptors, N-Methyl-D-Aspartate

2005

Glutamate-based therapeutic approaches: NR2B receptor antagonists.

Current opinion in pharmacology, 2006, Volume: 6, Issue:1

Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Huntington Disease; Pain; Phenols; Piperidines; Protein Conformation; Receptors, N-Methyl-D-Aspartate

2006

Other Studies

52 other study(ies) available for ifenprodil and glutamic acid

Article	Year
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2 Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1992
The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies. European journal of pharmacology, 1992, Aug-03, Volume: 226, Issue:4 Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate	1992
Effects of ifenprodil on the N-methyl-D-aspartate receptor ionophore complex in rat brain. Neurochemistry international, 1992, Volume: 21, Issue:1 Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium	1992
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex. Progress in neuro-psychopharmacology & biological psychiatry, 1991, Volume: 15, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine	1991
Polyamine and ifenprodil interactions with the NMDA receptor's glycine site. European journal of pharmacology, 1991, Sep-12, Volume: 208, Issue:1 Topics: Animals; Binding Sites; Drug Interactions; Glutamates; Glutamic Acid; Glycine; Male; Piperidines; Polyamines; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Statistics as Topic	1991
Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Molecular pharmacology, 1995, Volume: 48, Issue:5 Topics: Animals; Binding Sites; Cell Line; Glutamic Acid; Glycine; Humans; Mice; Piperidines; Rabbits; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection	1995
Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the epsilon 4 (NR2D) subunit. Neuroscience letters, 1995, Jan-30, Volume: 184, Issue:3 Topics: Animals; Glutamic Acid; Glycine; Histamine; Oocytes; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Xenopus laevis	1995
[3H]dizocilpine association kinetics distinguish stimulatory and inhibitory polyamine sites of N-methyl-D-aspartate receptors. Journal of neurochemistry, 1994, Volume: 63, Issue:3 Topics: Animals; Biguanides; Binding Sites; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Polyamines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium	1994
Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytosol; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine	1993
Pharmacological and immunological characterization of N-methyl-D-aspartate receptors in human NT2-N neurons. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2 Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immunoblotting; Kynurenic Acid; Neurons; Piperidines; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate	1996
Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:2 Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus	1996
A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. The Journal of physiology, 1996, Dec-15, Volume: 497 ( Pt 3) Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Models, Biological; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate	1996
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells. Experimental neurology, 1997, Volume: 148, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E	1997
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. Journal of neurochemistry, 1998, Volume: 70, Issue:3 Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis	1998
State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. British journal of pharmacology, 1998, Volume: 123, Issue:3 Topics: Animals; Benzamides; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channel Gating; Kinetics; Piperidines; Protein Binding; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis	1998
Protective effect of GV150526A on the glutamate-induced changes in basal and electrically-stimulated cytosolic Ca++ in primary cultured cerebral cortical cells. Neurochemistry international, 1998, Volume: 32, Issue:4 Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Indoles; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1998
An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:2 Topics: Animals; Arginine; CHO Cells; Cricetinae; Dizocilpine Maleate; Dopamine Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Iodine Radioisotopes; Piperidines; Point Mutation; Receptors, N-Methyl-D-Aspartate	1998
Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol delta 8-delta 7 isomerization. Biochemistry, 1999, Jan-19, Volume: 38, Issue:3 Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Asparagine; Carrier Proteins; Cell Membrane; Glutamic Acid; Histidine; Humans; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Peptide Fragments; Piperidines; Saccharomyces cerevisiae; Steroid Isomerases; Threonine; Tryptophan	1999
Properties of NMDA receptors in rat spinal cord motoneurons. The European journal of neuroscience, 1999, Volume: 11, Issue:3 Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord	1999
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1 Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Mice; Mollusk Venoms; Oocytes; Pentylenetetrazole; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Sound; Xenopus	2000
Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neurones. Neuroreport, 2000, Apr-27, Volume: 11, Issue:6 Topics: Animals; Cells, Cultured; Coculture Techniques; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Glycine; Ion Channels; Neocortex; Neurons; Patch-Clamp Techniques; Picrotoxin; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synapses	2000
Protective effects of ifenprodil against glutamate-induced neurotoxicity in cultured retinal neurons. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:10 Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Retina; Spermidine	2000
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nature neuroscience, 2001, Volume: 4, Issue:9 Topics: Allosteric Regulation; Animals; Binding Sites; Cell Line; Edetic Acid; Electric Conductivity; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Ligands; Peptide Fragments; Piperidines; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Zinc	2001
Establishment of CHO cell lines expressing four N-methyl-D-aspartate receptor subtypes and characterization of a novel antagonist PPDC. FEBS letters, 2001, Oct-05, Volume: 506, Issue:2 Topics: Animals; Calcium; CHO Cells; Cricetinae; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Glycine; Hot Temperature; Piperidines; Protein Isoforms; Receptors, N-Methyl-D-Aspartate; Valine	2001
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. Journal of neurophysiology, 2001, Volume: 86, Issue:4 Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Piperidines; Presynaptic Terminals; Quinolinic Acids; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin	2001
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. Brain research. Molecular brain research, 2002, Jan-31, Volume: 98, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space	2002
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nature neuroscience, 2002, Volume: 5, Issue:5 Topics: Brain-Derived Neurotrophic Factor; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Intracellular Membranes; Membrane Potentials; Mitochondria; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Synapses	2002
Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses. Journal of neuroscience research, 2002, May-01, Volume: 68, Issue:3 Topics: Animals; Cell Differentiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Fetus; Gene Deletion; Gene Targeting; Glutamic Acid; Mice; Mice, Knockout; Mutation; Neocortex; Neurons; Piperidines; Pregnancy; Protein Structure, Tertiary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tetrodotoxin	2002
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice. Experimental neurology, 2003, Volume: 183, Issue:2 Topics: Acetyltransferases; Animals; Biogenic Polyamines; Brain; Cell Count; Crosses, Genetic; Dose-Response Relationship, Drug; Drug Resistance; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Transgenic; Neurons; Pentylenetetrazole; Piperidines; Putrescine; Seizures	2003
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:6 Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil	2003
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-08, Volume: 24, Issue:36 Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate	2004
Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. Neuroscience, 2005, Volume: 130, Issue:1 Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Bicuculline; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Immunohistochemistry; Ion Channel Gating; Ion Channels; Membrane Potentials; Microscopy, Confocal; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solvents; Symporters; Time Factors; Toluene	2005
In vitro characterization of novel NR2B selective NMDA receptor antagonists. Neurochemistry international, 2005, Volume: 46, Issue:6 Topics: Animals; Binding Sites; Binding, Competitive; Calcium Signaling; Carrier Proteins; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kinetics; Membrane Potentials; Mice; Molecular Structure; Nerve Tissue Proteins; Patch-Clamp Techniques; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2005
Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence. The European journal of neuroscience, 2005, Volume: 22, Issue:6 Topics: Amphetamine-Related Disorders; Animals; Astrocytes; Calcium; Cell Communication; Central Nervous System Stimulants; Coculture Techniques; Conditioning, Operant; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Immunohistochemistry; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microscopy, Confocal; Neuroglia; Neurons; Piperidines; Pregnancy; Protein Kinase C; Pyridines; Quinoxalines; Receptors, Glutamate; Synaptic Transmission	2005
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:2 Topics: Animals; Apoptosis; Bridged Bicyclo Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Piperidines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Staurosporine	2006
Glutamate exocytosis from astrocytes controls synaptic strength. Nature neuroscience, 2007, Volume: 10, Issue:3 Topics: Analysis of Variance; Animals; Astrocytes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Microscopy, Immunoelectron; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Perforant Pathway; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission	2007
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells. The Journal of steroid biochemistry and molecular biology, 2007, Volume: 104, Issue:3-5 Topics: 2-Amino-5-phosphonovalerate; Cell Adhesion; Cell Line, Tumor; Excitatory Amino Acid Agonists; Glioma; Glutamic Acid; Humans; Hybrid Cells; Neurites; Neuroblastoma; Piperidines; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Steroids	2007
Rapid bidirectional switching of synaptic NMDA receptors. Neuron, 2007, Sep-06, Volume: 55, Issue:5 Topics: Aging; Animals; Brain; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Male; Organ Culture Techniques; Piperidines; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors	2007
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors. Molecular pharmacology, 2009, Volume: 75, Issue:1 Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Female; Glutamic Acid; Glycine; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Mice; Microinjections; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Piperidines; Plasmids; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Reference Standards; Sequence Homology, Amino Acid; Temperature; Xenopus laevis; Zinc	2009
Molecular determinants of multiple effects of nickel on NMDA receptor channels. Neurotoxicity research, 2009, Volume: 15, Issue:1 Topics: Animals; Binding Sites; Biophysical Phenomena; Cell Line, Transformed; Dose-Response Relationship, Drug; Electric Stimulation; Glutamic Acid; Humans; Membrane Potentials; Models, Molecular; Nickel; Oocytes; Patch-Clamp Techniques; Piperidines; Point Mutation; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Spermine; Trace Elements; Transfection; Xenopus; Zinc	2009
Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents. Neuroscience, 2010, Feb-03, Volume: 165, Issue:3 Topics: Animals; Cell Line; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Kinetics; Piperidines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Temperature	2010
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. European journal of pharmacology, 2010, Nov-25, Volume: 647, Issue:1-3 Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Hyperalgesia; Injections, Spinal; Isomerism; Ketamine; Male; Motor Activity; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	2010
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of neurochemistry, 2011, Volume: 117, Issue:3 Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium	2011
The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation. Neurochemistry international, 2012, Volume: 61, Issue:1 Topics: Animals; Cyclic AMP Response Element-Binding Protein; Excitatory Amino Acid Antagonists; Glutamic Acid; In Situ Hybridization; Male; MAP Kinase Signaling System; Phosphorylation; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus	2012
Ifenprodil effects on GluN2B-containing glutamate receptors. Molecular pharmacology, 2012, Volume: 82, Issue:6 Topics: Binding Sites; Glutamic Acid; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Kinetics; Ligands; Neuroprotective Agents; Piperidines; Polyamines; Protons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Zinc	2012
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats. PloS one, 2013, Volume: 8, Issue:10 Topics: Acute Disease; Animals; Antineoplastic Agents; Behavior, Animal; Cold Temperature; Diet; Glutamic Acid; Hyperalgesia; Immunoblotting; Magnetic Resonance Spectroscopy; Male; Metabolomics; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents	2013
Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors. Neuron, 2014, Mar-05, Volume: 81, Issue:5 Topics: Animals; Dimerization; Excitatory Amino Acid Antagonists; Glutamic Acid; HEK293 Cells; Humans; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sulfonamides; Trace Elements; Xenopus laevis; Zinc	2014
Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse. Journal of Alzheimer's disease : JAD, 2015, Volume: 45, Issue:2 Topics: Alanine Transaminase; Amyloid beta-Peptides; Analysis of Variance; Animals; Aspartic Acid; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred BALB C; Nerve Net; Neuronal Plasticity; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Pyruvic Acid; Synapses	2015
Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:9 Topics: Animals; Brain-Derived Neurotrophic Factor; Central Amygdaloid Nucleus; Conditioning, Classical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; Glutamic Acid; In Vitro Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Piperidines; Polymorphism, Single Nucleotide; Synapses; Valine	2015
Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015, Jul-05, Volume: 370, Issue:1672 Topics: Animals; Dendrites; Diazonium Compounds; Glutamic Acid; Mice; N-Methylaspartate; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyridines; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials	2015
Direct administration of ifenprodil and citalopram into the nucleus accumbens inhibits cue-induced nicotine seeking and associated glutamatergic plasticity. Brain structure & function, 2020, Volume: 225, Issue:7 Topics: Animals; Citalopram; Cues; Dendritic Spines; Drug-Seeking Behavior; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Neuronal Plasticity; Neurons; Nicotine; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Self Administration	2020
Ifenprodil Improves Long-Term Neurologic Deficits Through Antagonizing Glutamate-Induced Excitotoxicity After Experimental Subarachnoid Hemorrhage. Translational stroke research, 2021, Volume: 12, Issue:6 Topics: Animals; Blood-Brain Barrier; Glutamic Acid; Humans; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Subarachnoid Hemorrhage	2021