ifenprodil has been researched along with dizocilpine maleate in 124 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (2.42) | 18.7374 |
| 1990's | 52 (41.94) | 18.2507 |
| 2000's | 46 (37.10) | 29.6817 |
| 2010's | 22 (17.74) | 24.3611 |
| 2020's | 1 (0.81) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bottegoni, G; Cavalli, A; Daniele, S; Goldoni, L; Martini, C; Melchiorre, C; Piomelli, D; Pizzirani, D; Reggiani, A; Rosini, M; Simoni, E; Tarozzo, G; Trincavelli, ML | 1 |
| Nicklas, WJ; Zeevalk, GD | 1 |
| Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA | 1 |
| Darles, G; Graham, D; Langer, SZ | 1 |
| Meguri, H; Ogita, K; Ohgaki, T; Ohkawara, A; Suzuki, T; Uchida, S; Yoneda, Y | 1 |
| Fukuta, T; Ishimaru, H; Kameyama, T; Katoh, A; Nabeshima, T; Suzuki, H | 1 |
| Cler, JA; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Heikkila, RE; Riordan, DE; Sonsalla, PK | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Bakker, MH; Foster, AC | 1 |
| Millan, MJ | 1 |
| Bakker, MH; Foster, AC; McKernan, RM; Wong, EH | 1 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Steele, JE | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| Jackson, A; Sanger, DJ | 2 |
| Bagga, L; Derks, M; Doyle, KM; Purcell, WM | 1 |
| Goldstone, AD; Lu, CY; Sahgal, S; Trout, JJ | 1 |
| Nordholm, L; Sheardown, MJ; Suzdak, PD | 1 |
| Doyle, KM; Shaw, GG | 2 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Carrozza, DP; Molinoff, PB; Pritchett, DB; Williams, K; Zhong, J | 1 |
| Anegawa, NJ; Dichter, M; Lawrence, JJ; Lenz, S; Lynch, DR; Pritchett, DB | 1 |
| Hashimoto, K; London, ED; Mantione, CR; Neumeyer, JL; Spada, MR | 1 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Baudry, M; Marvizón, JC | 1 |
| De Sarro, A; De Sarro, GB | 1 |
| Molinoff, PB; Russell, SL; Shen, YM; Williams, K | 1 |
| Brave, S; French, D; Geter-Douglass, B; Witkin, JM | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR; Pritchett, DB | 1 |
| Atterwill, CK; Doyle, KM; Purcell, WM; Westgate, C | 1 |
| Aulakh, CS; Mazzola-Pomietto, P; Murphy, DL | 1 |
| Couratier, P; Dussartre, C; Hugon, J; Lesort, M; Terro, F | 1 |
| Johnson, SW; Wu, YN | 1 |
| Basile, AS; Berlin, C; Huang, JM; Skolnick, P; Webster, D; Xie, C | 1 |
| Cooke, MJ; Fisher, A; Fraser, CM; Stone, TW; Thompson, ID | 1 |
| Misawa, M; Suzuki, T; Tsuda, M | 4 |
| Orchinik, M; Tanapat, P; Weiland, NG | 1 |
| Barbour, MJ; Bolton, C; Paul, C; Scott, GS; Seiler, N | 1 |
| Leibrock, J; Prücher, H; Rautenberg, W | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Fischer, G; Heitz, MP; Kemp, JA; Kew, JN; Malherbe, P; Mohacsi, E; Mutel, V; Trube, G | 1 |
| Ruppersberg, JP | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR | 1 |
| Segal, JA; Skolnick, P | 1 |
| Ganguly, A; Keefe, KA | 1 |
| Aizenman, E; Brimecombe, JC; Gallagher, MJ; Lynch, DR | 1 |
| Adams, AC; Keefe, KA | 1 |
| Doyle, KM; Eddleston, A; Feerick, S; Higgins, GA; Kirkby, DL | 1 |
| Brotchie, JM; Hill, MP; Nash, JE | 1 |
| Berger, ML; Rebernik, P | 1 |
| Boyce, S; Hill, RG; Mason, G; O'Donnell, R; Rigby, M; Rupniak, NM; Sirinathsinghji, D; Webb, JK; Wyatt, A | 1 |
| Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS | 1 |
| Ahlemeyer, B; Hoffmann, GF; Kölker, S; Krieglstein, J | 2 |
| Höfner, G; Wanner, KT | 1 |
| Gottmann, K; Hatt, H; Mohrmann, R | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Healy, DJ; Hogg, AJ; Ibrahim, HM; Meador-Woodruff, JH | 1 |
| Gemignani, A; Paudice, P; Pittaluga, A; Raiteri, M | 1 |
| Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H | 1 |
| Gallagher, MJ; Guttmann, RP; Kurapathi, S; Lynch, DR; Mutel, V; Seifert, KM; Shim, SS | 1 |
| Aoki, K; Narita, M; Nomura, M; Suzuki, T; Yoshizawa, K | 1 |
| Mo, LL; Sundström, E | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Dave, JR; Ling, G; Lu, XM; Tortella, FC; Williams, AJ | 1 |
| Bakalkin, G; Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, C; Sakurada, T; Tadano, T; Tan-No, K; Terenius, L | 1 |
| Gibson, DA; Harris, BR; Littleton, JM; Rogers, DT | 1 |
| Blanchard, JA; Gibson, DA; Harris, BR; Holley, RC; Littleton, J; Mayer, S; Prendergast, MA | 1 |
| Boros, A; Dezso, P; Kolok, S; Nagy, J; Szombathelyi, Z | 1 |
| Guilarte, TR; Hashemzadeh-Gargari, H; McGlothan, JL; Toscano, CD | 1 |
| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Shibata, H; Takenaka, C | 1 |
| De Vry, J; Jentzsch, KR | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Dave, JR; Koenig, ML; Moffett, JR; Tortella, FC; Williams, AJ | 1 |
| Bristow, LJ; Clarke, HF; Grimwood, S; Guscott, MR; Hutson, PH; Murray, F | 1 |
| Honse, Y; Leslie, SW; Randall, PK | 1 |
| Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA | 1 |
| Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F | 1 |
| Bertram, EH; Kapur, J; Williamson, J; Yen, W | 1 |
| Hashimoto, K; Hattori, K; Iyo, M; Yanahashi, S; Yuasa, S | 1 |
| Giza, CC; Hovda, DA; Osteen, CL | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Bakalkin, G; Marinova, Z; Nakagawasai, O; Niijima, F; Sakurada, S; Sato, T; Satoh, S; Tadano, T; Takahashi, H; Tan-No, K; Terenius, L; Yakovleva, T | 1 |
| Dodd, PR; Lewis, RJ; Tsai, VW | 1 |
| Carta, M; Mameli, M; Partridge, LD; Valenzuela, CF | 1 |
| Kiyosue, K; Nakayama, K; Taguchi, T | 1 |
| Aoki, T; Kato, H; Miyoshi, K; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Cordeiro, MF; Fitzke, FW; Guo, L; Luong, V; Maass, A; Moss, SE; Salt, TE | 1 |
| Baudry, M; Zhou, M | 1 |
| Bonnert, TP; Fradley, RL; Heavens, RP; Hunt, V; Lawrence, JM; Macaulay, A; Rosahl, TW; Treacey, P; Usala, M; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Hessler, NA; Wang, J | 1 |
| Esashi, A; Furuta, S; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Tadano, T; Tan-No, K; Yasuhara, H | 1 |
| Georgiev, D; Kambe, Y; Takarada, T; Taniura, H; Yoneda, Y | 1 |
| Carbery, T; Geddes, JW; Nasr, P | 1 |
| Dehpour, AR; Ghasemi, M; Raza, M | 1 |
| Dehpour, AR; Ebrahimi, F; Ghasemi, M; Montaser-Kouhsari, L; Nezami, BG; Shafaroodi, H | 1 |
| Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ | 1 |
| Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V | 1 |
| Bose, R; Parkinson, FE; Zamzow, CR | 1 |
| Chang, CY; Jiang, X; Mennerick, S; Moulder, KL | 1 |
| Demb, JB; Manookin, MB; Stafford, BK; Weick, M | 1 |
| Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T | 1 |
| Alberdi, E; Martín-Satué, M; Matute, C; Solsona, C; Texidó, L | 1 |
| Djurić, D; Hrnčić, D; Lončar-Stevanović, H; Macut, D; Rašić-Marković, A; Stanojlović, O | 1 |
| Li, YQ; Mei, XP; Wang, W; Wei, YY; Wu, SX; Xu, LX; Zhang, MM; Zhang, T | 1 |
| Höfner, G; Müller, A; Parsons, CG; Renukappa-Gutke, T; Wanner, KT | 1 |
| During, MJ; Gray, JA; Nicoll, RA; Sakimura, K; Shi, Y; Usui, H | 1 |
| Kim, HJ; Shin, AH; Thayer, SA | 1 |
| Berch, AM; Della-Pace, ID; Fighera, MR; Furian, AF; Oliveira, MS; Rambo, LM; Ribeiro, LR; Royes, LF; Schramm, VG; Silva, LF; Stamm, DN | 1 |
| Di Maio, R; Greenamyre, JT; Hu, X; Mastroberardino, PG; Montero, LM | 1 |
| Morales, M; Spear, LP; Varlinskaya, EI | 1 |
| Morales, M; Spear, LP | 1 |
| Burgos, H; Buttigieg, A; Flores, O; Hernández, A; Morgan, C; Sáez-Briones, P | 1 |
| Chang, CH; Chen, YW; Gean, PW; Hsiao, YH; Yu, YJ | 1 |
| Itzhak, Y; Liddie, S | 1 |
| Berger, ML; Boykin, DW; Huang, TL; Ismail, MA; Jarak, I; Karminski-Zamola, G; Kaźmierczak, P; Kumar, A; Maciejewska, D; Mayence, A; Mottamal, M; Piantanida, I; Rebernik, P; Rezler, M; Vanden Eynde, JJ; Żabiński, J | 1 |
| Gunkel, BT; Hughes, MN; Prior, NA; Rogers, KK; Yates, JR | 1 |
| Buyukuysal, RL; Gul, Z; Gursoy, M | 1 |
1 review(s) available for ifenprodil and dizocilpine maleate
| Article | Year |
|---|---|
Treatment for psychological dependence on morphine: usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens.
Topics: Animals; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Humans; Intracellular Signaling Peptides and Proteins; Ketamine; Membrane Proteins; Mice; Morphine Dependence; Nucleus Accumbens; Piperidines; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2005 |
123 other study(ies) available for ifenprodil and dizocilpine maleate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Proliferation; Cerebral Cortex; Cholinesterase Inhibitors; Computer Simulation; Drug Combinations; Drug Design; Feasibility Studies; Galantamine; Humans; Male; Memantine; Neuroblastoma; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2012 |
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.
Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina | 1992 |
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1992 |
Effects of ifenprodil on the N-methyl-D-aspartate receptor ionophore complex in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium | 1992 |
Effects of N-methyl-D-aspartate receptor antagonists on carbon monoxide-induced brain damage in mice.
Topics: Animals; Binding Sites; Carbon Monoxide Poisoning; Dizocilpine Maleate; Glycine; Hippocampus; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Vasodilator Agents | 1992 |
Polyamines modulate events mediated by the N-methyl-D-aspartate (NMDA) receptor complex through an ifenprodil-insensitive pathway: in vivo measurements of cyclic GMP in the cerebellum.
Topics: Animals; Biogenic Polyamines; Cerebellum; Cyclic GMP; Dizocilpine Maleate; Injections, Intraventricular; Male; Methamphetamine; Mice; Neural Pathways; Ornithine; Pentylenetetrazole; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.
Topics: Amino Acids; Animals; Corpus Striatum; Dizocilpine Maleate; Male; Methamphetamine; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Convulsants; Corpus Striatum; Dialysis; Diazepam; Dizocilpine Maleate; Glutamate Decarboxylase; Haloperidol; Ibotenic Acid; Injections; Male; Nerve Degeneration; Pipecolic Acids; Piperazines; Piperidines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1991 |
Antagonists at the NMDA recognition site and blockers of the associated ion channel induce spontaneous tail-flicks in the rat.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ion Channels; Ketamine; Male; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Pipecolic Acids; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
[3H]MK-801 binding to N-methyl-D-aspartate receptors solubilized from rat brain: effects of glycine site ligands, polyamines, ifenprodil, and desipramine.
Topics: Animals; Binding Sites; Brain; Chromatography, Gel; Desipramine; Dizocilpine Maleate; Glycine; Ligands; Male; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Solubility; Tritium | 1991 |
Spermidine enhancement of [3H]MK-801 binding to the NMDA receptor complex in human cortical membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Cerebral Cortex; Dizocilpine Maleate; Female; Humans; In Vitro Techniques; Kynurenic Acid; Male; Membranes; Piperidines; Radioligand Assay; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1990 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-D-aspartate receptors?
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Chlordiazepoxide; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Drug Interactions; Generalization, Stimulus; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?
Topics: Animals; Biguanides; Dizocilpine Maleate; Histamine Release; In Vitro Techniques; Kinetics; Mast Cells; p-Methoxy-N-methylphenethylamine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Polyamines and NMDA receptors modulate pericapillary astrocyte swelling following cerebral cryo-injury in the rat.
Topics: Animals; Astrocytes; Biogenic Polyamines; Brain; Brain Injuries; Capillaries; Cold Temperature; Dizocilpine Maleate; Eflornithine; Ornithine Decarboxylase; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Statistics as Topic | 1995 |
AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Gerbillinae; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Kinetics; Male; Neurons; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
The mechanism of the neurotoxic effects of spermidine.
Topics: Animals; Cerebral Ventricles; Dizocilpine Maleate; Guanidines; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurotoxins; Oxidoreductases Acting on CH-NH Group Donors; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Stereotyped Behavior | 1994 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Dizocilpine Maleate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger | 1995 |
Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: differences with receptors formed from NR 1a and 2A.
Topics: Animals; Brain; Cell Survival; Dizocilpine Maleate; Electrophysiology; Membranes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Transfection | 1995 |
Further characterization of [3H]ifenprodil binding in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Rats; Rats, Inbred F344; Receptors, sigma | 1994 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
[3H]dizocilpine association kinetics distinguish stimulatory and inhibitory polyamine sites of N-methyl-D-aspartate receptors.
Topics: Animals; Biguanides; Binding Sites; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Polyamines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium | 1994 |
Anticonvulsant properties of non-competitive antagonists of the N-methyl-D-aspartate receptor in genetically epilepsy-prone rats: comparison with CPPene.
Topics: Acoustic Stimulation; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Dextromethorphan; Dizocilpine Maleate; Epilepsy; Injections, Intraperitoneal; Ketamine; Male; Movement; Phencyclidine; Piperazines; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro.
Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Cells, Cultured; Cerebral Cortex; Cloning, Molecular; Dizocilpine Maleate; Female; Gene Expression; Neurons; Oocytes; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transfection; Xenopus laevis | 1993 |
Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor.
Topics: Amino Acids; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Ibogaine; Male; Mice; Piperidines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Cell Line; Cloning, Molecular; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Genetic Variation; Humans; Kidney; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine; Transfection | 1996 |
Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex.
Topics: Animals; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Histamine Release; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneum; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Thalamus | 1996 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotective Agents; Piperazines; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Spermine; Tremor | 1996 |
NMDA receptor antagonists block development of tolerance to m-CPP-induced increases in ACTH concentrations in rats.
Topics: Adrenocorticotropic Hormone; Animals; Dimethyl Sulfoxide; Dizocilpine Maleate; Drug Tolerance; Kynurenic Acid; Male; Phencyclidine; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 1996 |
NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetus; Fluorescent Antibody Technique; Kynurenic Acid; Microscopy, Confocal; Neurons; Piperidines; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; tau Proteins | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Hearing Tests; Kanamycin; Male; N-Methylaspartate; Neomycin; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Interactions between ifenprodil and dizocilpine on mouse behaviour in models of anxiety and working memory.
Topics: Animals; Anxiety; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Memory; Mice; Mice, Inbred Strains; Piperidines | 1996 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraventricular; Injections, Spinal; Kynurenic Acid; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Subcutaneous; Kynurenic Acid; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1997 |
Chronic corticosterone treatment induces parallel changes in N-methyl-D-aspartate receptor subunit messenger RNA levels and antagonist binding sites in the hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Binding, Competitive; Cell Membrane; Corticosterone; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucocorticoids; Hippocampus; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Testosterone | 1997 |
N-methyl-D-aspartate receptor-mediated events contribute to neurovascular breakdown during experimental allergic encephalomyelitis.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cerebellum; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Male; Piperidines; Putrescine; Rats; Rats, Inbred Lew; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents | 1997 |
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
Topics: Animals; Calcium Channels; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Phenols; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 1997 |
[Ototoxicity of aminoglycoside antibiotics: an alternative in sight?].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Dizocilpine Maleate; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss, Sensorineural; Humans; Neuroprotective Agents; Piperidines; Risk Factors | 1997 |
Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Pentylenetetrazole; Piperidines; Reaction Time | 1997 |
Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions.
Topics: Amino Acid Sequence; Binding, Competitive; Chimera; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Mutagenesis, Site-Directed; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine | 1998 |
NMDA receptor antagonists potently suppress the spontaneous withdrawal signs induced by discontinuation of long-term diazepam treatment in Fischer 344 rats.
Topics: Administration, Oral; Animals; Anorexia; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Dizocilpine Maleate; Eating; Emotions; Excitatory Amino Acid Antagonists; Male; Motor Activity; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors; Weight Loss | 1998 |
Polyamine-like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Bacterial Agents; Carbohydrate Sequence; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kanamycin; Male; Molecular Sequence Data; Neomycin; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1998 |
Effects of NMDA receptor antagonists on D1 dopamine receptor-mediated changes in striatal immediate early gene expression: evidence for involvement of pharmacologically distinct NMDA receptors?
Topics: Animals; Corpus Striatum; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, Immediate-Early; Male; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 1998 |
An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.
Topics: Animals; Arginine; CHO Cells; Cricetinae; Dizocilpine Maleate; Dopamine Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Iodine Radioisotopes; Piperidines; Point Mutation; Receptors, N-Methyl-D-Aspartate | 1998 |
Differential effects of N-methyl-D-aspartate receptor blockade on eticlopride-induced immediate early gene expression in the medial and lateral striatum.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Gene Expression; Genes, Immediate-Early; Male; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Salicylamides | 1998 |
Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Memory, Short-Term; Motor Activity; Piperazines; Piperidines; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 1998 |
Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpine-treated rat.
Topics: Animals; Antiparkinson Agents; Binding, Competitive; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reserpine | 1999 |
Zinc and ifenprodil allosterically inhibit two separate polyamine-sensitive sites at N-methyl-D-aspartate receptor complex.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Brain; Cell Membrane; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Male; Neurons; Organ Specificity; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium; Zinc | 1999 |
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Lamotrigine; Male; Motor Activity; Pain Measurement; Phenols; Piperidines; Pyrrolidinones; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Triazines | 1999 |
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Mice; Mollusk Venoms; Oocytes; Pentylenetetrazole; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Sound; Xenopus | 2000 |
Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency.
Topics: Animals; Antibodies; Brain Diseases, Metabolic, Inborn; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Glutarates; Glutaryl-CoA Dehydrogenase; Neurons; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperidines; Rats | 2000 |
[3H]ifenprodil binding to NMDA receptors in porcine hippocampal brain membranes.
Topics: Animals; Azides; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanidines; Hippocampus; In Vitro Techniques; Kinetics; Membranes; Piperidines; Protein Binding; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Subcellular Fractions; Swine | 2000 |
Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neurones.
Topics: Animals; Cells, Cultured; Coculture Techniques; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Glycine; Ion Channels; Neocortex; Neurons; Patch-Clamp Techniques; Picrotoxin; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synapses | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Methylmalonic acid induces excitotoxic neuronal damage in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Cell Survival; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Methylmalonic Acid; Neurons; Neuroprotective Agents; Neurotoxins; NG-Nitroarginine Methyl Ester; Piperidines | 2000 |
Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Macaca nemestrina; Neurons; Organ Specificity; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thalamic Nuclei; Transcription, Genetic; Tritium | 2000 |
The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Indoles; Kynurenic Acid; Male; Maleimides; Neurons; Nitroarginine; Peptide Fragments; Pipecolic Acids; Piperazines; Piperidines; Potassium; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes; Zinc | 2000 |
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil.
Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2001 |
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.
Topics: Animals; Brain; Cell Line; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Kinetics; Mice; Mutation; Phenols; Piperidines; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine | 2001 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
Topics: Animals; Dextromethorphan; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Guanidines; Ketamine; Ligands; Male; Phencyclidine; Piperazines; Piperidines; Protein Subunits; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2001 |
Polyamine and redox modulation of [3H]MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex.
Topics: Animals; Biguanides; Cerebral Cortex; Dizocilpine Maleate; Hydrogen-Ion Concentration; Male; Neuroprotective Agents; Oxidation-Reduction; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Tritium | 2001 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Conotoxins; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Nerve Degeneration; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil.
Topics: Agmatine; Animals; Biguanides; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2002 |
Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus.
Topics: Acamprosate; Animals; Animals, Newborn; Calcium Signaling; Dizocilpine Maleate; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Taurine | 2002 |
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Kynurenic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Piperidines; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing | 2003 |
Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain.
Topics: Animals; Animals, Newborn; Binding Sites; Brain; Calcium Signaling; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Environmental Exposure; Female; Lead; Lead Poisoning, Nervous System; Male; Neurons; Phosphorylation; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2002 |
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Colforsin; Culture Techniques; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Immunohistochemistry; Magnesium; Mesencephalon; Neurons; Piperidines; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Time Factors; Tyrosine 3-Monooxygenase | 2003 |
Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Phencyclidine; Phenols; Piperidines; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Conotoxins; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Mexiletine; Neurons; Neuroprotective Agents; Piperidines; Pregnancy; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Staurosporine | 2003 |
The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze.
Topics: Administration, Oral; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Memory; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Swimming | 2003 |
Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil.
Topics: Alternative Splicing; Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Female; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2003 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Male; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 2004 |
Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Catalepsy; Cell Count; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Drug Interactions; Ethylenediamines; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Haloperidol; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Piperidines; Prazosin; Prosencephalon; Proto-Oncogene Proteins c-fos; Reaction Time; Receptors, N-Methyl-D-Aspartate; Time Factors | 2004 |
Injury-induced alterations in N-methyl-D-aspartate receptor subunit composition contribute to prolonged 45calcium accumulation following lateral fluid percussion.
Topics: Animals; Autoradiography; Behavior, Animal; Blotting, Western; Brain Injuries; Calcium; Calcium Radioisotopes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluoresceins; Fluorescent Dyes; Male; Occipital Lobe; Organic Chemicals; Parietal Lobe; Piperidines; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Trauma Severity Indices; Wounds, Nonpenetrating | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation.
Topics: Agmatine; Analysis of Variance; Animals; Behavior, Animal; Biguanides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Antagonists; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Nociceptin Receptor; Piperidines; Protein Precursors; Receptors, Opioid; Spinal Cord; Time Factors | 2005 |
The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor.
Topics: Alanine; Binding, Competitive; Cell Membrane; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Humans; Neurons; Neurotoxins; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermine | 2005 |
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Calcium; Calcium Channel Blockers; Chelating Agents; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Pregnenolone; Presynaptic Terminals; Quinolinic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors | 2005 |
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Count; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Ketamine; Membrane Potentials; N-Methylaspartate; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Statistics, Nonparametric; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors | 2005 |
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Piperidines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Staurosporine | 2006 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine | 2006 |
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor.
Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gene Targeting; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Motor Activity; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Xenopus laevis | 2006 |
Coordination of presynaptic and postsynaptic maturation in a zebra finch forebrain motor control nucleus during song learning.
Topics: Age Factors; Animals; Behavior, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Finches; In Vitro Techniques; Learning; Male; Membrane Potentials; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Synapses; Vocalization, Animal | 2006 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation.
Topics: Animals; Calcium; Cell Differentiation; Cell Line; Dizocilpine Maleate; Gene Expression Regulation; Growth Cones; Mice; Neurites; Neurotransmitter Agents; Piperidines; Polyamines; Protein Subunits; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2008 |
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity.
Topics: Adenosine Diphosphate; Animals; Corpus Striatum; Dizocilpine Maleate; Drug Interactions; Male; Memantine; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Nitro Compounds; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2009 |
NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Ketamine; Lithium Chloride; Male; Mice; Models, Animal; Motor Activity; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming; Time Factors | 2010 |
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Immobility Response, Tonic; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming | 2009 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes | 2010 |
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium.
Topics: Adenosine; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Inosine; N-Methylaspartate; Neurons; Piperidines; Purines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
Rapid activation of dormant presynaptic terminals by phorbol esters.
Topics: Analysis of Variance; Animals; Animals, Newborn; Calcium; Carbazoles; Carcinogens; Cells, Cultured; Colforsin; Dizocilpine Maleate; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Indoles; Maleimides; Neurons; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Piperidines; Presynaptic Terminals; Rats; Sucrose; Sweetening Agents; Vesicular Glutamate Transport Protein 1 | 2010 |
NMDA receptor contributions to visual contrast coding.
Topics: Animals; Contrast Sensitivity; Dizocilpine Maleate; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Guinea Pigs; In Vitro Techniques; Light; Mice; Mice, Inbred C57BL; N-Methylaspartate; Patch-Clamp Techniques; Photic Stimulation; Piperidines; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Visual Perception | 2010 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles; Male; Memantine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organoplatinum Compounds; Oxaliplatin; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord | 2011 |
Amyloid β peptide oligomers directly activate NMDA receptors.
Topics: Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Electrophysiological Phenomena; Female; Humans; Memantine; Neurons; Oocytes; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Xenopus laevis | 2011 |
The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats.
Topics: Animals; Dizocilpine Maleate; Homocysteine; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2011 |
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.
Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hyperalgesia; Indazoles; JNK Mitogen-Activated Protein Kinases; Male; Neuralgia; Neurons; Nitric Oxide Synthase Type I; Pain Measurement; Phenols; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord | 2011 |
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists.
Topics: Amino Alcohols; Binding Sites; Dizocilpine Maleate; Drug Design; Ether-A-Go-Go Potassium Channels; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Ligands; Molecular Structure; Molecular Targeted Therapy; N-Methylaspartate; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2011 |
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo.
Topics: Animals; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Mice; Patch-Clamp Techniques; Piperidines; Protein Subunits; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2011 |
Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.
Topics: Animals; Cell Culture Techniques; Cell Survival; Culture Media; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Memantine; Microscopy, Confocal; Neurons; Neuroprotective Agents; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Synapses; tat Gene Products, Human Immunodeficiency Virus; Transfection | 2012 |
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cell Membrane; Creatine; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoenzymes; Male; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide Synthase; Piperidines; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2012 |
Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Male; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Pilocarpine; Piperidines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Compounds | 2013 |
Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Social Facilitation | 2013 |
The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
Topics: Aging; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibition, Psychological; Male; Motor Activity; Piperidines; Quinoxalines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Social Behavior | 2014 |
Preference for high-fat diet is developed by young Swiss CD1 mice after short-term feeding and is prevented by NMDA receptor antagonists.
Topics: Animals; Blood Glucose; Diet, High-Fat; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Food Preferences; Ketamine; Male; Mice; Mice, Inbred Strains; Piperidines; Receptors, N-Methyl-D-Aspartate | 2014 |
Social isolation-induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice.
Topics: Affective Symptoms; Aggression; Animals; Animals, Newborn; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Gene Expression Regulation; Hippocampus; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Piperidines; Prepulse Inhibition; Random Allocation; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Social Isolation; Swimming; Synaptosomes | 2015 |
Variations in the stimulus salience of cocaine reward influences drug-associated contextual memory.
Topics: Aminoacetonitrile; Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Male; Memory; Mice, Inbred C57BL; Nitric Oxide Synthase Type I; Piperidines; Receptors, N-Methyl-D-Aspartate; Reward | 2016 |
Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
Topics: Animals; Binding Sites; Brain; Dizocilpine Maleate; Molecular Docking Simulation; Pentamidine; Piperazine; Piperazines; Piperidines; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 2015 |
Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure.
Topics: Animals; Behavior, Animal; Choice Behavior; Cycloserine; Delay Discounting; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Impulsive Behavior; Ketamine; Ligands; Male; Memantine; Pipecolic Acids; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 2017 |
Sigma receptor ligands haloperidol and ifenprodil attenuate hypoxia induced dopamine release in rat striatum.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Haloperidol; Hypoxia; Ligands; Nomifensine; Ouabain; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2022 |