idx184 and phosphoramidic-acid

idx184 has been researched along with phosphoramidic-acid* in 1 studies

Other Studies

1 other study(ies) available for idx184 and phosphoramidic-acid

ArticleYear
Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    We have previously reported the power of combining a 5'-phosphoramidate ProTide, phosphate pro-drug, motif with a 6-methoxy purine pro-drug entity to generate highly potent anti-HCV agents, leading to agents in clinical trial. We herein extend this work with the disclosure that a variety of alternative 6-substituents are tolerated. Several compounds exceed the potency of the prior 6-methoxy leads, and in almost every case the ProTide is several orders of magnitude more potent than the parent nucleoside. We also demonstrate that these agents act as pro-drugs of 2'-C-methyl guanosine monophosphate. We have also reported the novel use of hepatocyte cell lysate as an ex vivo model for ProTide metabolism.

    Topics: Amides; AMP Deaminase; Antiviral Agents; Cell Line, Tumor; Drug Design; Drug Evaluation, Preclinical; Guanosine Monophosphate; Hepacivirus; Hepatitis C; Humans; Hydrolysis; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Phosphoric Acids; Phosphorylation; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Virus Replication

2011