idazoxan has been researched along with prazosin in 244 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 85 (34.84) | 18.7374 |
| 1990's | 113 (46.31) | 18.2507 |
| 2000's | 31 (12.70) | 29.6817 |
| 2010's | 15 (6.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, RC; Chapleo, CB; England, DC; Myers, PL; Roach, AG; Smith, CF; Stillings, MR; Tulloch, IF | 1 |
| Harsing, LG; Somogyi, GT; Szabo, L; Szantay, C; Toth, I; Vizi, ES | 1 |
| Haubrich, DR; Hlasta, DJ; Luttinger, D; Perrone, MH; Silbernagel, MJ; Ward, SJ | 1 |
| Chapleo, CB; Fagan, GP; Lane, AC; Myers, M; Roach, AG; Smith, CF; Stillings, MR; Welbourn, AP | 1 |
| Butler, RC; Chapleo, CB; Doxey, JC; Myers, PL; Roach, AG; Smith, CF | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Ahrén, B; Dall, FH; Gregersen, H; Jensen, SL; Jørgensen, CS | 1 |
| De Backer, JP; De Keyser, J; De Vos, H; Van Liefde, I; Vauquelin, G | 1 |
| Muir, TC; Nally, JE | 1 |
| Enero, MA; Ricci, D; Taira, CA | 1 |
| Schwietert, R; Van Zwieten, PA; Wilffert, B; Wilhelm, D | 1 |
| Berridge, TL; Doxey, JC; Roach, AG; Smith, CF | 1 |
| Raich, PC; Zimmerman, BG | 1 |
| Branch, CA; Knuepfer, MM | 1 |
| Harris, GC; Hausken, ZE; Williams, JT | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Midgley, LP | 1 |
| Gustafson, I; Westerberg, EJ; Wieloch, T | 1 |
| Cagampang, FR; Coen, CW; Maeda, K; Ohkura, S; Ota, K; Tsukamura, H | 1 |
| Clarke, RW; Harris, J | 1 |
| Goncharevskaya, OA | 1 |
| Culman, J; Qadri, F; Rascher, W; Unger, T; Veltmar, A | 2 |
| García-Barrado, MJ; Moratinos, J; Reverte, M | 2 |
| Gitler, MS; Jose, PA; Piccio, MM; Robillard, JE | 1 |
| Chamba, G; Pujol, JF; Renaud, B; Rousset, C; Weissmann, D | 1 |
| Murugaian, J; Sapru, H; Sundaram, K | 1 |
| Cervo, L; Samanin, R | 1 |
| Nickel, B; Szelenyi, I | 1 |
| Bültmann, R; Starke, K; von Kügelgen, I | 2 |
| Nicholson, T; Osman, TE | 1 |
| Bourin, M; Bradwejn, J; Hascoët, M | 1 |
| Collewijn, H; Pompeiano, O; Tan, HS; van Neerven, J | 1 |
| Baldwin, DL; Miller, JM; Nuttall, AL; Ohlsén, KA | 1 |
| Danzebrink, RM; Gebhart, GF | 1 |
| Medgett, IC; Rajanayagam, MA; Rand, MJ | 1 |
| Guth, BD; Heusch, G; Ross, J; Seitelberger, R; Thaulow, E | 2 |
| Bache, RJ; Laxson, DD | 1 |
| Ferrari, RA; Hamel, LT; Haubrich, DR; Perrone, MH | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Montastruc, JL; Senard, JM; Stillings, M | 1 |
| Assenmacher, I; Barbanel, G; Gaillet, S; Malaval, F; Szafarczyk, A | 1 |
| Akpogomeh, BA; Johns, EJ | 1 |
| Hsu, WH; Ko, JC; Smith, BE | 1 |
| Doxey, JC; John, GW; Reid, JL; Walter, DS | 1 |
| Dettmar, PW; Kelly, J; MacDonald, A | 1 |
| Andrioli, GC; Cavazzani, P; Folghera, S; Göthert, M; Maura, G; Raiteri, M; Schalnus, R; Schlicker, E | 1 |
| Guth, BD; Heusch, G; Ross, J; Seitelberger, R | 1 |
| Chen, DG; Chen, RX; Li, JM; Xu, B; Zhang, L | 1 |
| Berger, J; Brown, CM; Clark, RD; Garg, P; Kilpatrick, AT; MacKinnon, AC; Spedding, M; Weinhardt, KK | 1 |
| Brandon, S; Cragoe, EJ; Guyer, CA; Horstman, DA; Limbird, LE; Wilson, AL | 1 |
| Berlan, M; Estan, L; Montastruc, JL; Senard, JM; Tran, MA | 1 |
| Hall, MT; Hamilton, CA; Kane, KA; Reid, JL; Rodger, IW; Wadsworth, RM | 1 |
| Boulat, O; Maitre, L; Waldmeier, P | 1 |
| Berridge, CW; Dunn, AJ | 1 |
| Calvete, J; Hayes, R; Sever, PS; Thom, S | 1 |
| Louis, WJ; Rand, MJ; Story, DF; Tung, LH | 1 |
| Buckingham, RE; Clapham, JC; Cooper, SM; Wilson, C | 1 |
| Majewski, H; Rump, LC | 1 |
| Chariot, J; Chovet, M; Rozé, C; Sautereau, D; Tsocas, A | 1 |
| Lacroix, JS; Lundberg, JM | 1 |
| Leighton, HJ; Ramagopal, MV | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Simonato, M; Spalluto, P; Tanganelli, S; Tomasini, C | 1 |
| Chapelain, B; Gargouil, YM; Mahe, L; Neliat, G | 1 |
| Majewski, H; Murphy, TV | 1 |
| Bache, RJ; Dai, XZ; Homans, DC; Laxson, DD | 1 |
| Couture, R; Laneuville, O; Reader, TA | 1 |
| Jurcovicová, J; Krulich, L; Le, T | 1 |
| Bache, RJ; Dai, XZ; Homans, DC; Lindstrom, P; Schwartz, JS; Sublett, E | 1 |
| Folly, G; Harsing, LG; Lonart, G; Vizi, ES | 1 |
| Berthold, H; Engel, G; Fozard, JR | 1 |
| Cichini, G; Kraupp, O; Singer, EA; Valenta, B | 1 |
| Sanger, DJ | 1 |
| Cattaneo, AG; Doxey, JC; Efendic, S; Ostenson, CG | 1 |
| Feder, HH; Peterson, CS; Thornton, JE; Vincent, PA | 1 |
| Näsström, J; Post, C; Uhlén, S; Wikberg, JE | 1 |
| Bowman, CL; Kimelberg, HK | 1 |
| Kenakin, TP; Novak, PJ | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Rando, S; Simonato, M; Tanganelli, S | 1 |
| Downing, OA; Stein, W; Wilson, KA; Wilson, VG | 1 |
| Hollingworth, RM; Hsu, WH; Smith, BE | 1 |
| Woodman, OL | 2 |
| Hey, JA; Ito, T; Koss, MC | 1 |
| Rand, MJ; Standford-Starr, CA; Story, DF | 1 |
| Calvete, J; Hayes, R; Martin, G; Sever, P; Thom, S | 1 |
| Hesse, IF; Johns, EJ | 1 |
| Duval, N; Hicks, PE; Langer, SZ | 1 |
| Medgett, IC | 1 |
| Bunney, BS; Chiodo, LA | 1 |
| Brière, R; Grondin, L; Reader, TA | 2 |
| Kaniucki, MD; Perec, CJ; Stefano, FJ | 1 |
| Livingston, A; Nolan, A; Waterman, A | 1 |
| Bernath, S; Gaal, J; Harsing, LG; Kapocsi, J; Somogyi, GT; Vizi, ES | 1 |
| Dickinson, KE; McKernan, RM; Miles, CM; Sever, PS | 1 |
| Hicks, PE; Langer, SZ; Najar, M; Vidal, M | 1 |
| Dettmar, PW; Lord, JA | 1 |
| Kopaciewicz, LJ; Kopia, GA; Ruffolo, RR | 1 |
| Medgett, IC; Papanicolaou, M | 1 |
| Bousquet, P; Feldman, J | 1 |
| Broadley, KJ; Williamson, KL | 1 |
| Crump, MH; Greer, MH; Hsu, WH; Schaffer, DD; Shaw, RN | 1 |
| Hey, JA; Koss, MC | 1 |
| Bennett, T; Gardiner, SM | 2 |
| Feldman, PD; Moises, HC | 1 |
| Bennett, T; Foulkes, R; Gardiner, SM | 1 |
| Cassell, JF; McLachlan, EM; Sittiracha, T | 1 |
| Belkhiri, M; Nicholson, T; Osman, TE | 1 |
| Ahdieh, HB; Feder, HH | 1 |
| Engel, J; Hård, E; Lindh, AS | 1 |
| Dirksen, R; Van der Laan, JW | 1 |
| Dickinson, SL; Gadie, B; Tulloch, IF | 1 |
| Besser, GM; Grossman, A; Holly, JM; Rees, LH; Tsagarakis, S | 1 |
| Bloom, SR; Brown, DC; Brown, MJ; Schumer, B; Struthers, AD | 1 |
| Appleby, GJ; Clark, MG; Colquhoun, EQ; Edwards, SJ; McKinstry, WJ; Rattigan, S; Richter, EA | 1 |
| Engel, JA; Goldstein, M; Johannessen, K; Liljequist, S | 1 |
| Johns, EJ; Manitius, J | 1 |
| Dyke, AC; Widdop, RE | 1 |
| Brière, R; Diop, L; Grondin, L; Reader, TA | 1 |
| Langer, SZ; Pimoule, C | 1 |
| Hamilton, CA; Hannah, JA; Reid, JL | 1 |
| Dabiré, H; Dausse, JP; Meyer, P; Mouillé, P; Schmitt, H | 1 |
| Paciorek, PM; Shepperson, NB | 1 |
| Langer, SZ; Medgett, IC | 2 |
| García-Sáinz, JA; Pushpendran, CK | 1 |
| North, RA; Yoshimura, M | 1 |
| Hicks, PE; Langer, SZ; Medgett, IC | 1 |
| Gadie, B; Lane, AC; McCarthy, PS; Tulloch, IF; Walter, DS | 1 |
| Medgett, IC; Rajanayagam, MA | 1 |
| Curtis-Prior, PB; Tan, S | 1 |
| Cahusac, PM; Hill, RG | 1 |
| Advenier, C; Biyah, K | 1 |
| Hussain, JF; Kendall, DA; Pinthong, D; Wilson, VG | 1 |
| Bemis, K; Danuser, H; Thor, KB | 1 |
| Doak, GJ; Reid, AR; Sawynok, J | 1 |
| Beleslin, DB; Jovanović-Mićić, D; Samardzić, R | 1 |
| Cable, HC; el-Mansoury, A; Morgan, NG | 1 |
| Blaylock, NA; Kendall, DA; Wilson, VG; Wright, IK | 1 |
| Gazzola, C; Hunter, RA; Lisle, AT; Magner, T | 1 |
| Baker, CH; Nessellroth, S; Ortiz-Tweed, M; Price, JM; Sutton, ET | 1 |
| Atrens, DM; Fleischhauer, AE; Kuhlman, SJ; Siviy, SM | 1 |
| Aston, N; Chess-Williams, R; Couldwell, C | 1 |
| Rossi, R; Scharrer, E | 1 |
| Fukuda, H; Fukushima, C; Ono, H | 1 |
| Chen, DG; Chen, RX; Xu, B | 1 |
| Robinson, NE; Wang, Z; Yu, M | 1 |
| Acciarri, N; Antonelli, T; Beani, L; Bianchi, C; Caló, G; Fabrizi, A; Ferraro, L; Simonato, M; Tanganelli, S | 1 |
| Berdeaux, A; Ghaleh, B; Giudicelli, JF; Vigue, B | 1 |
| Baez, M; Cohen, ML; Cushing, DJ; Kursar, JD; Schenck, K | 1 |
| Pennefather, JN; Ventura, S | 1 |
| Ala-Uotila, S; Kurose, H; Marjamäki, A; Oker-Blom, C; Pohjanoksa, K; Scheinin, M; Sizmann, D | 1 |
| Penner, SB; Smyth, DD | 2 |
| Elased, KM; Furman, BL | 1 |
| Amabeoku, G; Chandomba, R | 1 |
| Sickles, AE; Stehouwer, DJ; Taylor, LL; Van Hartesveldt, C | 1 |
| Kengatharan, M; Mackay, D | 1 |
| Kulkarni, SK; Sharma, A | 1 |
| Grenhoff, J; Svensson, TH | 1 |
| Angel, I; Grosset, A; Langer, SZ; Perrault, G; Schoemaker, H | 1 |
| Cervo, L; Rossi, C; Samanin, R | 1 |
| Amabeoku, GJ | 1 |
| Edwall, L; Funato, A; Kerezoudis, NP; Olgart, L | 1 |
| de Boer, TH; Nefkens, F; van Delft, AM; van Helvoirt, A | 1 |
| Bousquet, P; De Jong, W; Feldman, J; Monassier, L; Roegel, JC | 1 |
| Bohmann, C; Rist, W; Rump, LC; Schollmeyer, P | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Crema, F; Del Tacca, M; Lazzeri, G; Natale, G | 1 |
| Bylund, DB; Cerutis, DR; Deupree, JD; Hinton, KA | 1 |
| Clarke, DE; Ford, AP; Lachnit, WG | 1 |
| Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM | 1 |
| Abrahams, TP; Liu, W; Varner, KJ | 1 |
| Herman, CA; Luczy, G; Uhlén, S; Wikberg, JE | 1 |
| Garyfallou, VT; Hess, DL; Kohama, SG; Urbanski, HF | 1 |
| Intengan, HD; Smyth, DD | 1 |
| Brock, JA; McLachlan, EM; Rayner, SE | 1 |
| Békási, E; Gyertyán, I; Haller, J; Makara, GB; Pintér, I | 1 |
| Elliott, J | 1 |
| Bearham, MC; Heal, DJ; Hutchins, LJ; Jackson, HC; Mazurkiewicz, SE; Needham, AM | 1 |
| Carón, RW; Deis, RP; Salicioni, AM | 1 |
| Guyenet, PG; Huangfu, D | 1 |
| Egyed, A; Gyertyán, I; Haller, J; Makara, GB; Pintér, I | 1 |
| Hertel, P; Nomikos, GG; Svensson, TH | 1 |
| Butterworth, RF; Buu, PN; Michalak, A; Rose, C | 1 |
| Dailey, JW; Jobe, PC; Steenbergen, JL; Yan, QS | 1 |
| Audinot, V; Cistarelli, L; Gobert, A; Millan, MJ; Newman-Tancredi, A; Rivet, JM | 1 |
| Fang, F; Proudfit, HK | 1 |
| Caramona, MM; Figueiredo, IV; Guimarães, S; Moura, D; Paiva, MQ | 1 |
| Giroux, N; Reader, TA; Rossignol, S | 1 |
| Chariot, J; Nagain-Domaine, C; Presset, O; Rozé, C | 1 |
| Aicher, SA; Drake, CT | 1 |
| Bobirnac, I; Gazi, L; Loetscher, E; Parsley, S; Schoeffter, P | 1 |
| Dawson, LA; Geiger, A; Nguyen, HQ | 1 |
| Nott, MW; Rand, MJ; Thaina, P | 1 |
| Goepel, M; Krege, S; Michel, MC; Michelotti, GA; Price, DT; Schwinn, DA | 1 |
| Hébert, C; Lalonde, R; Reader, TA; Strazielle, C | 1 |
| Benamour, K; Chang-Fong, J; Cussac, M; Morand, JM; Szymonski, B; Thomasson, F | 1 |
| Iida, S; Ishihama, K; Kogo, M; Koizumi, H; Matsuya, T; Mori, A; Tanaka, S | 1 |
| Chen, DY; Chen, HC; Liang, KC | 1 |
| Clarke, RW; Harris, J; Houghton, AK | 1 |
| Dausse, JP; Giudicelli, Y; Ilhami, N; Khalid, M | 1 |
| Corrêa, FM; Peres-Polon, VL; Tavares, RF | 1 |
| De Luca, LA; Menani, JV; Moreira, Tdos S; Renzi, A; Takakura, AC | 1 |
| Goldstein, I; Huang, YH; Kim, NN; Min, K; Traish, AM | 1 |
| De Luca, LA; dos Santos Moreira, T; Menani, JV; Renzi, A; Takakura, AC | 1 |
| Kindlundh, A; Lindblom, J; Mugisha, P; Nyberg, F; Uhlén, S | 1 |
| Huang, DL; Patel, S; Sagher, O | 1 |
| Brock, JA; McLachlan, EM; Yeoh, M | 1 |
| Fagerholm, V; Hein, L; Philipp, M; Scheinin, M | 1 |
| Kehr, J; Scheel-Krüger, J; Weikop, P | 1 |
| Bourin, M; Dailly, E; Hascoët, M; Masse, F | 1 |
| Bouysset, F; Vayssettes-Courchay, C; Verbeuren, TJ | 1 |
| Brock, JA; Yeoh, M | 1 |
| Blum, JW; Hammon, HM; Ontsouka, EC; Zbinden, Y | 1 |
| Greenup, JL; Leverenz, JB; Peskind, ER; Raskind, MA; Szot, P; White, SS | 2 |
| Ahsan, MR; Lehmann, ML; Quartermain, D; Stone, EA; Yan, L; Yeretsian, J | 1 |
| Bylund, DB; Happe, HK; Murrin, LC; Sanders, JD; Szot, P; Weinshenker, D | 1 |
| Feliu-Mojer, M; Jiménez-Rivera, CA; Vázquez-Torres, R | 1 |
| Kolaj, M; Renaud, LP | 1 |
| Araújo, IG; Cedraz-Mercez, PL; Costa-e-Sousa, RH; Lepletier, A; Mecawi, AS; Medeiros, MA; Olivares, EL; Reis, LC; Rocha, FF | 1 |
| Stuchlik, A; Vales, K | 1 |
| Chancellor, MB; de Groat, WC; Kaiho, Y; Kamo, I; Miyazato, M; Sugaya, K; Yoshimura, N | 1 |
| Huang, Y; O'Donnell, JM; Whisler, LR; Xiang, Y; Zhang, HT | 1 |
| Colombari, DS; De Luca, LA; Menani, JV; Moreira, TS; Takakura, AC | 1 |
| Chang, ST; Chuang, CH; Kao, YC; Lin, YL; Liu, YP; Tung, CS | 1 |
| Acheson, AG; Dashwood, MR; Eames, T; Gruss, H; Henry, Y; Rayment, SJ; Scholefield, JH; Simpson, JA; Wilson, VG | 1 |
| Bennett, DJ; D'Amico, J; Gorassini, MA; Murray, KC; Rank, MM; Stephens, MJ | 1 |
| Amodeo, FS; Brummett, CM; Hong, EK; Janda, AM; Lydic, R | 1 |
| Docherty, JR | 1 |
| Aono, Y; Cools, AR; Koshikawa, N; Saigusa, T; Takada, K; Uchida, T; Verheij, MM | 1 |
| Hackett, D; Heal, DJ; Hutson, PH; Murray, F; Vickers, SP | 1 |
| Essali, N; Sanders, J | 1 |
| Mizuyama, R; Shimegi, S; Soma, S; Suemastu, N | 1 |
| Dobrzański, G; Kwiatkowska, K; Pradel, K; Przewłocki, R; Solecki, WB; Szklarczyk, K | 1 |
| Hartzler, LK; Santin, JM; Vallejo, M | 1 |
| Chae, HK; Choi, S; Hahm, DH; Heo, H; Kim, SK; Kim, W | 1 |
1 review(s) available for idazoxan and prazosin
| Article | Year |
|---|---|
Pharmacology and biochemistry of noradrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Clonidine; Dioxins; Idazoxan; Muscle, Smooth, Vascular; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sympathectomy, Chemical; Vasoconstriction | 1982 |
1 trial(s) available for idazoxan and prazosin
| Article | Year |
|---|---|
Human vascular smooth muscle responses mediated by alpha 2 mechanisms in vivo and in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Arteries; Brimonidine Tartrate; Dioxanes; Doxazosin; Forearm; Humans; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha | 1985 |
242 other study(ies) available for idazoxan and prazosin
| Article | Year |
|---|---|
Heteroaromatic analogues of the alpha 2-adrenoreceptor partial agonist clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Heterocyclic Compounds; Male; Rats; Vas Deferens | 1989 |
Berbanes: a new class of selective alpha 2-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Alkaloids; Animals; Berberine Alkaloids; Chemical Phenomena; Chemistry; Dioxanes; Guinea Pigs; Idazoxan; Ileum; Male; Muscle Contraction; Phentolamine; Prazosin; Pulmonary Artery; Rabbits; Rats; Receptors, Adrenergic, alpha; Vas Deferens; Yohimbine | 1987 |
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Imidazoles; Indoles; Male; Mice; Nociceptors; Pain; Prazosin; Quinolines; Rats; Structure-Activity Relationship; Vas Deferens | 1987 |
Indoline analogues of idazoxan: potent alpha 2-antagonists and alpha 1-agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Indoles; Male; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship | 1988 |
alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Dioxins; Dose-Response Relationship, Drug; Idazoxan; Male; Mice; Phenylephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Synapses; Vas Deferens | 1983 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Effects of noradrenaline and galanin on duodenal motility in the isolated perfused porcine pancreatico-duodenal block.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Duodenum; Galanin; Gastrointestinal Motility; Idazoxan; In Vitro Techniques; Neuropeptides; Norepinephrine; Pancreas; Peptides; Perfusion; Prazosin; Receptors, Adrenergic, alpha; Swine | 1992 |
Regional distribution of alpha 2A- and alpha 2B-adrenoceptor subtypes in postmortem human brain.
Topics: Adrenergic alpha-Antagonists; Aged; Binding, Competitive; Brain; Cadaver; Dioxanes; Humans; Idazoxan; Middle Aged; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tissue Distribution | 1992 |
The electrical and mechanical responses of the rabbit saphenous artery to nerve stimulation and drugs.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Arteries; Dioxanes; Electric Stimulation; Electrophysiology; Evoked Potentials; Idazoxan; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Phospholipids; Prazosin; Rabbits; Suramin; Sympathetic Nervous System | 1992 |
Cardiovascular responses of sinoaortic-denervated rats to intracerebroventricular injection of alpha 1- and alpha 2-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Denervation; Dioxanes; Heart Rate; Idazoxan; Injections, Intraventricular; Phenylephrine; Prazosin; Pressoreceptors; Rats; Rats, Inbred Strains | 1992 |
The effect of some alpha-adrenoceptor antagonists on spontaneous myogenic activity in the rat portal vein and the putative involvement of ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; In Vitro Techniques; Male; Phentolamine; Portal Vein; Potassium Channels; Prazosin; Rats; Rats, Inbred Strains; Vasoconstriction; Yohimbine | 1992 |
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Idazoxan; Imidazoles; Insulin; Male; Muscles; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens | 1992 |
Renal hemodynamics in canine DOCA-salt hypertension: effect of calcium channel blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Desoxycorticosterone; Dioxanes; Dogs; Heart Rate; Hexamethonium Compounds; Hypertension; Idazoxan; Nephrectomy; Prazosin; Renal Circulation | 1992 |
Adrenergic mechanisms underlying cardiac and vascular responses to cocaine in conscious rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cocaine; Dioxanes; Drug Interactions; Heart Rate; Idazoxan; Male; Metoprolol; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasodilation; Yohimbine | 1992 |
Cocaine induced synchronous oscillations in central noradrenergic neurons in vitro.
Topics: Adrenergic alpha-Antagonists; Animals; Cocaine; Dioxanes; Evoked Potentials; Idazoxan; In Vitro Techniques; Kinetics; Kynurenic Acid; Locus Coeruleus; Male; Membrane Potentials; Neurons; Oscillometry; Picrotoxin; Prazosin; Rats; Rats, Wistar; Strychnine; Synapses | 1992 |
Characterization of phencyclidine-induced effects on neuropeptide Y systems in the rat caudate-putamen.
Topics: 4-Aminobutyrate Transaminase; Adrenergic beta-Antagonists; Aminocaproates; Aminooxyacetic Acid; Animals; Benzazepines; Carbazoles; Corpus Striatum; Dioxanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Idazoxan; Male; Naloxone; Neuropeptide Y; Phencyclidine; Prazosin; Psychotropic Drugs; Putamen; Pyrimidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors; Vigabatrin | 1992 |
Effects of ischemia on regional ligand binding to adrenoceptors in the rat brain.
Topics: Adrenergic beta-Antagonists; Animals; Autoradiography; Brain; Dioxanes; Idazoxan; Ischemic Attack, Transient; Male; Pindolol; Prazosin; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic; Time Factors | 1992 |
Alpha 2-adrenergic receptors are involved in the suppression of luteinizing hormone release during acute fasting in the ovariectomized estradiol-primed rats.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Dioxanes; Estradiol; Fasting; Female; Idazoxan; Luteinizing Hormone; Ovariectomy; Piperoxan; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1992 |
An analysis of adrenergic influences on the sural-gastrocnemius reflex of the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Female; Idazoxan; Injections, Spinal; Male; Muscles; Prazosin; Rabbits; Reflex; Sural Nerve; Sympathetic Nervous System; Yohimbine | 1992 |
Alpha 2-adrenoceptor control of ion and water transport in the newt renal distal tubule.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Cell Membrane Permeability; Chlorine; Dioxanes; Drug Combinations; Idazoxan; Kidney Tubules, Distal; Magnesium; Norepinephrine; Potassium; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Salamandridae; Sodium; Water-Electrolyte Balance | 1992 |
Involvement of adrenergic and angiotensinergic receptors in the paraventricular nucleus in the angiotensin II-induced vasopressin release.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Dioxanes; Idazoxan; Male; Norepinephrine; Paraventricular Hypothalamic Nucleus; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Angiotensin | 1992 |
Role of alpha-adrenoceptors in control of plasma potassium in conscious rabbits.
Topics: Animals; Apamin; Calcium Channels; Clonidine; Dioxanes; Ethanolamines; Hyperkalemia; Idazoxan; Potassium; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Verapamil | 1991 |
Changes in plasma glucose and lactate evoked by alpha and beta 2-adrenoceptor stimulation in conscious fasted rabbits.
Topics: Albuterol; Analysis of Variance; Animals; Blood Glucose; Clonidine; Dioxanes; Epinephrine; Fasting; Idazoxan; Lactates; Male; Picolinic Acids; Prazosin; Propanolamines; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Spectrophotometry | 1991 |
Characterization of renal alpha-adrenoceptor subtypes in sheep during development.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Binding, Competitive; Dioxanes; Fetus; Idazoxan; Kidney; Kidney Cortex; Prazosin; Receptors, Adrenergic, alpha; Sheep; Yohimbine | 1991 |
Distribution of alpha-1 and alpha-2 binding sites in the rat locus coeruleus.
Topics: Animals; Autoradiography; Binding Sites; Dioxanes; Idazoxan; Locus Coeruleus; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Tyrosine 3-Monooxygenase | 1991 |
Microinjections of norepinephrine into the intermediolateral cell column of the spinal cord exert excitatory as well as inhibitory effects on the cardiac function.
Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Dioxanes; Heart; Heart Rate; Idazoxan; Male; Microinjections; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Spinal Cord; Sympathetic Nervous System; Tachycardia | 1991 |
Clonidine causes antidepressant-like effects in rats by activating alpha 2-adrenoceptors outside the locus coeruleus.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Clonidine; Desipramine; Dioxanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Hydroxydopamines; Idazoxan; Locus Coeruleus; Male; Neurons; Norepinephrine; Oxidopamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Pharmacological profile of flupirtine, a novel centrally acting, non-opioid analgesic drug.
Topics: Adrenergic alpha-Antagonists; Aminopyridines; Analgesics; Animals; Dioxanes; Drug Interactions; Electric Stimulation; Idazoxan; Mice; Muscle Relaxation; Muscle Tonus; Pain Measurement; Prazosin; Rats; Rats, Inbred Strains; Reaction Time; Reserpine | 1991 |
Contraction-mediating alpha 2-adrenoceptors in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Drug Interactions; Idazoxan; Male; Mice; Muscle Contraction; Neuropeptide Y; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Suramin; Vas Deferens; Yohimbine | 1991 |
Alpha-2 adrenoreceptors mediate clonidine-induced hypoinsulinaemia in sheep.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Clonidine; Dioxanes; Eating; Female; Idazoxan; Injections, Intravenous; Insulin; Male; Prazosin; Receptors, Adrenergic, alpha; Sheep | 1991 |
Behavioral models in mice. Implication of the alpha noradrenergic system.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Depression; Dioxanes; Hydroxamic Acids; Idazoxan; Male; Mice; Motor Activity; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Swimming | 1991 |
Effects of alpha-noradrenergic substances on the optokinetic and vestibulo-ocular responses in the rabbit: a study with systemic and intrafloccular injections.
Topics: Adaptation, Physiological; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cerebellum; Clonidine; Dioxanes; Eye Movements; Female; Idazoxan; Injections, Intravenous; Male; Microinjections; Phenylephrine; Prazosin; Rabbits; Reflex, Vestibulo-Ocular | 1991 |
Catecholaminergic pathway involved in angiotensin II-induced vasopressin release.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Dioxanes; Idazoxan; Injections; Male; Paraventricular Hypothalamic Nucleus; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasopressins | 1991 |
Influence of topically applied adrenergic agents on cochlear blood flow.
Topics: Administration, Topical; Albuterol; Animals; Azepines; Cochlea; Dioxanes; Epinephrine; Female; Guinea Pigs; Idazoxan; Isoproterenol; Lasers; Male; Norepinephrine; Phentolamine; Phenylephrine; Prazosin; Propranolol; Round Window, Ear; Sympathomimetics | 1991 |
Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral nociception.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Idazoxan; Male; Pain; Prazosin; Rats; Rats, Inbred Strains; Yohimbine | 1990 |
Vasoconstrictor responses of rat tail artery to sympathetic nerve stimulation contain a component due to activation of postjunctional beta- or alpha 2-adrenoceptors.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Calcium; Colforsin; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Neurotransmitter Agents; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Regional Blood Flow; Sympathetic Nervous System; Tail; Vasoconstriction | 1990 |
Myocardial effects of selective alpha-adrenoceptor blockade during exercise in dogs.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Aorta; Blood Pressure; Dioxanes; Dogs; Heart; Idazoxan; Motor Activity; Myocardium; Norepinephrine; Prazosin | 1990 |
Coronary arteriolar vasoconstriction in myocardial ischaemia: coronary vasodilator reserve during ischaemia.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Constriction, Pathologic; Coronary Circulation; Coronary Disease; Coronary Vessels; Dioxanes; Dogs; Heart Rate; Idazoxan; Physical Exertion; Prazosin | 1990 |
Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro.
Topics: Adrenergic alpha-Antagonists; Amino Acids; Animals; Brain; Cells, Cultured; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Prazosin; Rats; Receptors, Adrenergic, alpha; Synaptosomes; Vas Deferens | 1990 |
Identification of human platelet alpha 2-adrenoceptors with a new antagonist [3H]-RX821002, a 2-methoxy derivative of idazoxan.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Oxymetazoline; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
[Implication of alpha-2 adrenergic post-synaptic receptors in the central catecholaminergic stimulation of the corticotropic axis in rats].
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Clonidine; Depression, Chemical; Dioxanes; Drug Therapy, Combination; Female; Idazoxan; Injections, Intraventricular; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1990 |
The alpha-adrenoceptor mediating the tubular actions of the renal nerves in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Glomerular Filtration Rate; Hypertension; Idazoxan; Kidney; Male; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Circulation | 1990 |
Xylazine enhances porcine myometrial contractility in vitro: possible involvement of alpha 2-adrenoceptors and Ca2+ channels.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium Channels; Carbachol; Dioxanes; Female; Idazoxan; Myometrium; Prazosin; Receptors, Adrenergic, alpha; Swine; Uterine Contraction; Verapamil; Xylazine; Yohimbine | 1990 |
Selective alpha 2-adrenoceptor blockade does not enhance glucose-evoked insulin release.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Dioxanes; Drug Interactions; Glucose; Idazoxan; Insulin; Male; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains | 1990 |
Pre- and post-junctional alpha-adrenoceptor-mediated responses in the rat gastric fundus in-vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholinergic Fibers; Dioxanes; Electric Stimulation; Gastric Fundus; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Prazosin; Rats; Rats, Inbred Strains | 1990 |
Modulation of 5-hydroxytryptamine release by presynaptic inhibitory alpha 2-adrenoceptors in the human cerebral cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Animals; Cerebral Cortex; Clonidine; Dioxanes; Female; Guinea Pigs; Humans; Idazoxan; In Vitro Techniques; Male; Methoxamine; Middle Aged; Prazosin; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes | 1990 |
Alpha-adrenergic regulation of myocardial performance in the exercising dog: evidence for both presynaptic alpha 1- and alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Dioxanes; Dogs; Feedback; Idazoxan; Myocardial Contraction; Norepinephrine; Physical Exertion; Prazosin; Receptors, Adrenergic, alpha; Synapses | 1990 |
Alpha 2-adrenergic coronary constriction in ischemic myocardium during exercise.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Dioxanes; Dogs; Idazoxan; Physical Exertion; Prazosin; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Vasoconstriction | 1990 |
[Modulation of norepinephrine release in sympathetic nerve endings in renal hypertensive dogs].
Topics: Adrenergic alpha-Antagonists; Animals; Cocaine; Dioxanes; Dogs; Female; Hypertension, Renal; Idazoxan; Male; Nerve Endings; Norepinephrine; Prazosin; Sympathetic Nervous System; Tyramine | 1990 |
Affinity of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for alpha-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled alpha 2-adrenoceptor vs the [3H]yohimbine-labeled site.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Indoles; Isoquinolines; Ligands; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Yohimbine | 1990 |
An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.
Topics: Affinity Labels; Allosteric Regulation; Amino Acid Sequence; Animals; Aspartic Acid; Brimonidine Tartrate; Dioxanes; DNA Mutational Analysis; Epinephrine; Idazoxan; In Vitro Techniques; Molecular Sequence Data; Oxymetazoline; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Sodium; Structure-Activity Relationship; Swine; Transfection; Yohimbine | 1990 |
Reserpine induces vascular alpha 2-adrenergic supersensitivity and platelet alpha 2-adrenoceptor up-regulation in dog.
Topics: Adipose Tissue; Animals; Blood Platelets; Blood Pressure; Cardiovascular System; Catecholamines; Cell Membrane; Clonidine; Dioxanes; Dogs; Heart Rate; Idazoxan; Male; Norepinephrine; Posture; Prazosin; Receptors, Adrenergic, alpha; Reserpine; Up-Regulation; Yohimbine | 1990 |
Noradrenaline sensitivity and calcium fluxes in arteries from rabbits with perinephritis hypertension.
Topics: Angiotensin II; Animals; Aorta; Calcium; Cocaine; Dioxanes; Hypertension, Renovascular; Idazoxan; Kidney; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Norepinephrine; Potassium Chloride; Prazosin; Rabbits; Time Factors | 1990 |
3,4-Dihydroxyphenylacetic acid (DOPAC) as an index of noradrenaline turnover: effects of Hydergine and vincamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Cerebellum; Dihydroergotoxine; Dioxanes; Dopamine; Dopamine beta-Hydroxylase; Drug Interactions; Female; Haloperidol; Hippocampus; Idazoxan; Locus Coeruleus; Norepinephrine; Prazosin; Rats; Vincamine | 1990 |
DSP-4-induced depletion of brain norepinephrine produces opposite effects on exploratory behavior 3 and 14 days after treatment.
Topics: Animals; Benzylamines; Brain Chemistry; Cerebral Cortex; Clonidine; Dioxanes; Exploratory Behavior; Hippocampus; Idazoxan; Male; Methoxyhydroxyphenylglycol; Mice; Norepinephrine; Phenylephrine; Prazosin; Restraint, Physical; Sympathomimetics | 1990 |
In vivo and in vitro studies of alpha 2-adrenoceptor responses in human vascular smooth muscle.
Topics: Adult; Animals; Arm; Brimonidine Tartrate; Dioxanes; Dioxins; Doxazosin; Epinephrine; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Vasomotor System | 1985 |
Cardiac alpha-adrenoceptors: postjunctional and prejunctional.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Antagonists; Animals; Calcium; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; Idazoxan; In Vitro Techniques; Labetalol; Methoxamine; Myocardial Contraction; Myocardium; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Stimulation, Chemical; Verapamil | 1986 |
Alpha 1-adrenoceptor-mediated contraction of rabbit mesenteric artery: a role for intra- and extracellular calcium pools.
Topics: Animals; Calcium; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha | 1987 |
Modulation of norepinephrine release through alpha 1- and alpha 2-adrenoceptors in rat isolated kidney.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Kidney; Male; Norepinephrine; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System | 1987 |
Central and peripheral effects of prostaglandin E2 and enprostil on exocrine pancreatic secretion in rats.
Topics: Animals; Dinoprostone; Dioxanes; Dose-Response Relationship, Drug; Enprostil; Idazoxan; Injections, Intraventricular; Male; Pancreas; Pancreatic Juice; Prazosin; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Vagus Nerve; Yohimbine | 1989 |
Sympathetic vascular control of the pig nasal mucosa: adrenoceptor mechanisms in blood flow and volume control.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Desipramine; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Nasal Mucosa; Norepinephrine; Oxymetazoline; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic; Regional Blood Flow; Rheology; Swine; Sympathetic Nervous System | 1989 |
Analysis of the presence of postjunctional alpha-2 adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Phenoxybenzamine; Prazosin; Rats; Receptors, Adrenergic, alpha; Regression Analysis | 1989 |
Changes in cortical acetylcholine and gamma-aminobutyric acid outflow during morphine withdrawal involve alpha-1 and alpha-2 receptors.
Topics: Acetylcholine; Animals; Clonidine; Dioxanes; Female; gamma-Aminobutyric Acid; Guinea Pigs; Idazoxan; Locus Coeruleus; Male; Morphine; Naloxone; Prazosin; Receptors, Adrenergic, alpha; Substance Withdrawal Syndrome | 1989 |
The role of alpha- and beta-adrenoceptors in the response to noradrenaline of lymphatic vessels isolated from the bovine mesentery.
Topics: Animals; Cattle; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Lymphatic System; Mesentery; Methoxamine; Norepinephrine; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1989 |
Modulation of noradrenaline release in slices of rat kidney cortex through alpha 1- and alpha 2-adrenoceptors.
Topics: Animals; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Indomethacin; Kidney Cortex; Male; Methoxamine; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Circulation; Theophylline | 1989 |
The role of alpha 1- and alpha 2-adrenergic receptors in mediation of coronary vasoconstriction in hypoperfused ischemic myocardium during exercise.
Topics: Animals; Coronary Circulation; Coronary Disease; Dioxanes; Dogs; Female; Hemodynamics; Idazoxan; Male; Physical Exertion; Prazosin; Receptors, Adrenergic, alpha; Regional Blood Flow; Vasoconstriction | 1989 |
Effects of suramin and alpha, beta-methylene ATP indicate noradrenaline-ATP co-transmission in the response of the mouse vas deferens to single and low frequency pulses.
Topics: Adenosine Triphosphate; Animals; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Mice; Muscle, Smooth; Norepinephrine; Prazosin; Suramin; Synaptic Transmission; Vas Deferens; Yohimbine | 1989 |
Intrathecal bradykinin acts presynaptically on spinal noradrenergic terminals to produce antinociception in the rat.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Biogenic Monoamines; Bradykinin; Catecholamines; Catheters, Indwelling; Dioxanes; Endorphins; Hydroxydopamines; Idazoxan; Injections, Spinal; Kallidin; Male; Naloxone; Oxidopamine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord; Yohimbine | 1989 |
Prolactin (PRL) release-inhibiting properties of the alpha 2 adrenergic receptor antagonist idazoxan: comparison with yohimbine.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Clonidine; Dioxanes; Dioxins; Growth Hormone; Idazoxan; Kinetics; Male; Morphine; Norepinephrine; Prazosin; Prolactin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Restraint, Physical; Yohimbine | 1989 |
Coronary flow during exercise after selective alpha 1- and alpha 2-adrenergic blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Coronary Circulation; Coronary Vessels; Dioxanes; Dogs; Idazoxan; Physical Exertion; Prazosin; Receptors, Adrenergic, alpha; Vascular Resistance; Vasoconstriction | 1989 |
Failure of selective antagonists (CH-38083 and idazoxan) to distinguish between prejunctional and postjunctional alpha 2-adrenoreceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Berberine; Berberine Alkaloids; Blood Pressure; Decerebrate State; Dioxanes; Dioxins; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Idazoxan; Male; Neuromuscular Junction; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Buspirone; Dioxanes; Female; Fenclonine; Idazoxan; Indoles; Mice; Morphine Dependence; Naloxone; Prazosin; Receptors, Serotonin; Tetrahydronaphthalenes | 1989 |
Effects of urapidil on catecholamine turnover and release in the central nervous system of the rat.
Topics: Animals; Blood Pressure; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Dioxanes; Dopamine; Electric Stimulation; Haloperidol; Idazoxan; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Piperazines; Prazosin; Rats; Rats, Inbred Strains | 1989 |
Discriminative stimulus effects of the alpha 2-adrenoceptor antagonist idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dioxins; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Idazoxan; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Diabetes Mellitus, Experimental; Dioxanes; Female; Glucose; Idazoxan; Insulin; Islets of Langerhans; Male; Phentolamine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Streptozocin; Yohimbine | 1989 |
Different roles of alpha-noradrenergic receptor subtypes in regulating lordosis.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dioxins; Estradiol; Female; Guinea Pigs; Idazoxan; Posture; Prazosin; Progesterone; Receptors, Adrenergic, alpha; Sexual Behavior, Animal; Yohimbine | 1989 |
Guanfacine inhibits excitatory amino acid release from rat cerebral cortex through a non-adrenergic mechanism.
Topics: Amino Acids; Animals; Aspartic Acid; Autonomic Nervous System; Cerebral Cortex; Dioxanes; Glutamates; Guanfacine; Guanidines; Idazoxan; In Vitro Techniques; Male; Phenylacetates; Prazosin; Rats; Rats, Inbred Strains; Veratridine | 1989 |
Pharmacological properties of the norepinephrine-induced depolarization of astrocytes in primary culture: evidence for the involvement of an alpha 1-adrenergic receptor.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Dioxanes; Idazoxan; Kinetics; Membrane Potentials; Norepinephrine; Prazosin; Rats; Receptors, Adrenergic, alpha; Yohimbine | 1987 |
Classification of phenoxybenzamine/prazosin-resistant contractions of rat spleen to norepinephrine by Schild analysis: similarities and differences to postsynaptic alpha-2 adrenoceptors.
Topics: Alkylation; Animals; Dioxanes; Drug Resistance; Idazoxan; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spleen; Yohimbine | 1988 |
Inversion of the alpha-2 and alpha-1 noradrenergic control of the cortical release of acetylcholine and gamma-aminobutyric acid in morphine-tolerant guinea pigs.
Topics: Acetylcholine; Animals; Cerebral Cortex; Clonidine; Dioxanes; Drug Tolerance; Female; gamma-Aminobutyric Acid; Guinea Pigs; Idazoxan; Locus Coeruleus; Male; Morphine; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha | 1988 |
A comparison of the actions of noradrenaline and UK-14,304 in the longitudinal smooth muscle of the rat isolated portal vein--no evidence for a population of post-junctional alpha 2-adrenoceptors.
Topics: Animals; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1988 |
The bradycardic and mydriatic effects of chlordimeform and its demethylated analogs in the rat: antagonism by idazoxan but not by prazosin.
Topics: Amidines; Animals; Chlorphenamidine; Dioxanes; Dioxins; Heart Rate; Idazoxan; Insecticides; Male; Methylation; Prazosin; Proadifen; Pupil; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Structure-Activity Relationship | 1988 |
Adrenoceptor subtypes involved in the baroreceptor reflex constriction of large coronary arteries in the anaesthetized dog.
Topics: Animals; Coronary Vessels; Dioxanes; Dogs; Idazoxan; Prazosin; Pressoreceptors; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Vascular Resistance; Vasoconstriction | 1988 |
Studies on the mechanism of prazosin induced sympatho-inhibition.
Topics: Adrenergic Fibers; Amines; Animals; Cats; Central Nervous System; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Hypothalamus, Posterior; Idazoxan; Prazosin; Receptors, Adrenergic, alpha; Spinal Cord; Yohimbine | 1988 |
Evidence for the involvement of alpha 1-adrenoceptors in negative feedback regulation of noradrenergic transmitter release in rat atria.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Electric Stimulation; Feedback; Female; Heart Atria; Idazoxan; Methoxamine; Neuromuscular Junction; Norepinephrine; Phentolamine; Prazosin; Rats; Receptors, Adrenergic, alpha; Synaptic Transmission | 1985 |
The role of alpha-adrenoceptors in the regulation of renal tubular sodium reabsorption and renin secretion in the rabbit.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Guanabenz; Hemodynamics; Idazoxan; Kidney; Kidney Tubules; Male; Methoxamine; Natriuresis; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Renin; Sodium | 1985 |
Dopamine preferentially stimulates postsynaptic alpha 2-adrenoceptors in the femoral vascular bed, but alpha 1-adrenoceptors in the renal vascular bed of the anaesthetised dog.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Dioxanes; Dogs; Dopamine; Dopamine Antagonists; Female; Femoral Artery; Femoral Vein; Idazoxan; Kidney; Male; Prazosin; Receptors, Adrenergic, alpha; Regional Blood Flow; Stimulation, Chemical; Vasoconstriction | 1985 |
alpha 2-Adrenoceptors mediate sympathetic vasoconstriction in distal segments of rat tail artery.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Dioxanes; Idazoxan; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Tail; Vasoconstriction | 1985 |
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons.
Topics: Anesthetics; Animals; Antipsychotic Agents; Biomechanical Phenomena; Chloral Hydrate; Clozapine; Dibenzazepines; Dioxanes; Dopamine; Drug Combinations; Haloperidol; Idazoxan; Male; Mesencephalon; Neurons; Prazosin; Rats; Rats, Inbred Strains; Trihexyphenidyl | 1985 |
Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: role of disulfide and sulfhydryl groups.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry; Dioxanes; Dithiothreitol; Ethylmaleimide; Idazoxan; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
Blockade of postsynaptic alpha 2-adrenoceptors enhances responses to mixed alpha 1/alpha 2-agonists in rat submaxillary gland.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Idazoxan; Isoproterenol; Nordefrin; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Saliva; Submandibular Gland | 1986 |
The effects of alpha 2 adrenoceptor agonists on airway pressure in anaesthetized sheep.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Airway Resistance; Animals; Clonidine; Dioxanes; Female; Histamine; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Methoxamine; Prazosin; Pyrilamine; Sheep; Tripelennamine; Xylazine | 1986 |
CH-38083, a selective, potent antagonist of alpha-2 adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Berberine; Berberine Alkaloids; Binding, Competitive; Brain; Dioxanes; Dopamine; Guinea Pigs; Idazoxan; In Vitro Techniques; Male; Mice; Muscle, Smooth; Norepinephrine; Prazosin; Rabbits; Radioligand Assay; Rats; Receptors, Adrenergic, alpha | 1986 |
Heterogeneity between soluble human and rabbit splenic alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; Lectins; Oxymetazoline; Phentolamine; Prazosin; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Solubility; Spleen; Sulfhydryl Reagents; Yohimbine | 1986 |
Possible involvement of presynaptic alpha 1-adrenoceptors in the effects of idazoxan and prazosin on 3H-noradrenaline release from tail arteries of SHR.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Dioxins; Electric Stimulation; Idazoxan; Male; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Yohimbine | 1986 |
The effect of alpha 2-adrenoceptor agonists on the acid secretory responses of rat isolated gastric mucosa to electrical field stimulation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Gastric Acid; Gastric Mucosa; Histamine; Idazoxan; In Vitro Techniques; Male; Pentagastrin; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains | 1986 |
Alpha adrenoceptor regulation of coronary artery blood flow in normal and stenotic canine coronary arteries.
Topics: Adrenergic alpha-Antagonists; Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Circulation; Coronary Vessels; Dioxanes; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Heart Rate; Idazoxan; Male; Nadolol; Prazosin; Receptors, Adrenergic, alpha; Regional Blood Flow; Sympathetic Nervous System | 1986 |
Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: competition studies with [3H]prazosin and [3H]idazoxan.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Binding, Competitive; Cerebral Cortex; Dioxanes; Dioxins; Idazoxan; Kinetics; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1987 |
Effects of blockade of alpha 1- and alpha 2-adrenoceptors on vasoconstrictor responses to single and twin pulse stimulation in rat tail artery.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Cocaine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Prazosin; Rats; Rats, Inbred Strains; Regional Blood Flow; Tail; Vasoconstriction | 1986 |
The blood pressure effects of alpha-adrenoceptor antagonists injected in the medullary site of action of clonidine: the nucleus reticularis lateralis.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Clonidine; Dioxanes; Female; Idazoxan; Isoquinolines; Male; Medulla Oblongata; Piperazines; Prazosin; Yohimbine | 1987 |
Characterization of the alpha-adrenoceptors mediating positive inotropy of rat left atria by use of selective agonists and antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Myocardial Contraction; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1987 |
Further evidence to support the alpha 2-adrenergic nature of amitraz-induced decrease in intestinal motility.
Topics: Adrenergic alpha-Agonists; Animals; Depression, Chemical; Dioxanes; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guinea Pigs; Idazoxan; Ileum; Insecticides; Prazosin; Toluidines | 1987 |
Opposing central autonomic actions of alpha 1- and alpha 2-adrenoceptor antagonists on oculomotor tone.
Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System; Dioxanes; Electric Stimulation; Female; Idazoxan; Injections, Intravenous; Male; Prazosin; Pupil; Rats; Sciatic Nerve | 1987 |
The role of alpha 1- and alpha 2-adrenoceptors in the coronary vasoconstrictor responses to neuronally released and exogenous noradrenaline in the dog.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Carotid Arteries; Coronary Vessels; Dioxanes; Dogs; Heart Rate; Idazoxan; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Regional Blood Flow; Tyramine; Vascular Resistance; Vasoconstriction | 1987 |
Involvement of beta 2-adrenoceptor-mediated mechanisms in the cardiovascular responses to alpha 1- and alpha 2-adrenoceptor antagonism in conscious, unrestrained, Long Evans and Brattleboro rats.
Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Captopril; Dioxanes; Heart Rate; Hemodynamics; Idazoxan; Male; Phentolamine; Prazosin; Propanolamines; Rats; Rats, Brattleboro; Receptors, Adrenergic, beta; Restraint, Physical | 1988 |
Electrophysiological evidence for alpha 1- and alpha 2-adrenoceptors in solitary tract nucleus.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Epinephrine; Idazoxan; Male; Medulla Oblongata; Methoxamine; Neurons; Norepinephrine; Prazosin; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex | 1988 |
The cardiovascular responses to sequential inhibition of alpha-adrenoceptors, the renin-angiotensin system and vasopressin in rats with adrenal regeneration hypertension.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Circadian Rhythm; Dioxanes; Hypertension; Idazoxan; Male; Nephrectomy; Prazosin; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Receptors, Vasopressin; Renin-Angiotensin System; Vasopressins | 1988 |
The effect of temperature on neuromuscular transmission in the main caudal artery of the rat.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Dioxanes; Female; Idazoxan; In Vitro Techniques; Muscle, Smooth, Vascular; Neuromuscular Junction; Prazosin; Rats; Synaptic Transmission; Tail; Temperature; Time Factors | 1988 |
Regional hemodynamic responses to adrenoceptor antagonism in conscious rats.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Abdominal; Blood Pressure; Captopril; Deamino Arginine Vasopressin; Dioxanes; Idazoxan; Male; Mesenteric Arteries; Prazosin; Propanolamines; Propranolol; Rats; Rats, Brattleboro; Reference Values; Species Specificity; Ultrasonics; Vascular Resistance | 1988 |
Inhibition of rumination in sheep by alpha-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Energy Intake; Epinephrine; Gastrointestinal Motility; Idazoxan; Prazosin; Rumen; Sheep | 1988 |
Sex differences in nuclear androgen receptors in guinea pig brain and the effects of an alpha 2 noradrenergic blocker on androgen receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cell Nucleus; Dioxanes; Dioxins; Estrenes; Female; Guinea Pigs; Idazoxan; Kinetics; Male; Metribolone; Orchiectomy; Organ Specificity; Ovariectomy; Prazosin; Receptors, Androgen; Reference Values; Sex Factors; Testosterone; Testosterone Congeners | 1988 |
Effect of clonidine on ultrasonic vocalization in preweaning rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Body Temperature; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Hot Temperature; Idazoxan; Prazosin; Rats; Rats, Inbred Strains; Reference Values; Ultrasonics; Vocalization, Animal | 1988 |
Dipropylacetate-induced shaking behaviour in the rat: a role of spinal alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Idazoxan; Injections, Intraventricular; Male; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord; Valproic Acid | 1988 |
Alpha 1- and alpha 2-adrenoreceptor antagonists differentially influence locomotor and stereotyped behaviour induced by d-amphetamine and apomorphine in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Dextroamphetamine; Dioxanes; Idazoxan; Male; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Stereotyped Behavior; Time Factors | 1988 |
Acetylcholine and norepinephrine stimulate the release of corticotropin-releasing factor-41 from the rat hypothalamus in vitro.
Topics: Acetylcholine; Animals; Calcium; Corticotropin-Releasing Hormone; Dioxanes; Hypothalamus; Idazoxan; In Vitro Techniques; Kinetics; Male; Moxisylyte; Norepinephrine; Potassium; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Timolol | 1988 |
Selective alpha 2 receptor blockade facilitates the insulin response to adrenaline but not to glucose in man.
Topics: Adult; Blood Glucose; Dioxanes; Epinephrine; Glucose; Humans; Idazoxan; Insulin; Insulin Secretion; Islets of Langerhans; Male; Prazosin; Receptors, Adrenergic, alpha | 1985 |
Alpha-adrenergic receptors in rat skeletal muscle.
Topics: Animals; Binding Sites; Dihydroalprenolol; Dioxanes; Female; Idazoxan; Kinetics; Male; Muscles; Peptidyl-Dipeptidase A; Phentolamine; Phenylephrine; Prazosin; Rats; Receptors, Adrenergic, alpha; Sarcolemma; Yohimbine | 1986 |
Activation of alpha 2-adrenoreceptors enhances haloperidol-induced suppression of operant behavior.
Topics: Animals; Behavior, Animal; Brain Chemistry; Clonidine; Conditioning, Operant; Dihydroxyphenylalanine; Dioxanes; Drug Interactions; Haloperidol; Idazoxan; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
An investigation into the alpha-adrenoceptor mediating renal nerve-induced calcium reabsorption by the rat kidney.
Topics: Animals; Blood Pressure; Calcium; Dioxanes; Idazoxan; Kidney; Kidney Function Tests; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Circulation | 1986 |
Characterization of post-junctional alpha-adrenoceptors in the rat isolated perfused femoral artery.
Topics: Animals; Aorta; Azepines; Dioxanes; Dose-Response Relationship, Drug; Femoral Artery; Idazoxan; In Vitro Techniques; Male; Methoxamine; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasoconstriction | 1987 |
Adrenergic receptor and catecholamine distribution in rat cerebral cortex: binding studies with [3H]prazosin, [3H]idazoxan and [3H]dihydroalprenolol.
Topics: Alprenolol; Animals; Catecholamines; Cerebral Cortex; Chromatography, High Pressure Liquid; Dihydroalprenolol; Dioxanes; Dioxins; Electrochemistry; Idazoxan; Male; Prazosin; Rats; Receptors, Adrenergic; Tissue Distribution; Tritium | 1987 |
Peripheral alpha 1- and alpha 2-adrenoreceptor mechanisms in blood pressure control.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Blood Pressure; Clonidine; Dioxins; Guanabenz; Idazoxan; Male; Muscle, Smooth, Vascular; Norepinephrine; Phenoxybenzamine; Phentolamine; Prazosin; Pressoreceptors; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Synapses; Vascular Resistance | 1983 |
In vitro studies with (imidazolinyl-2)-2-benzodioxane-1-4 ((+/-)-170 150), a new potent alpha 2-adrenoceptor blocking agent.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Clonidine; Dioxins; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine | 1982 |
alpha 1-Adrenoceptor agonist activity of alpha 2-adrenoceptor antagonists in the pithed rat preparation.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dioxins; Female; Idazoxan; Norepinephrine; Prazosin; Quinolizines; Rats; Rats, Inbred Strains; Reserpine; Spinal Cord | 1983 |
Heterogeneity of smooth muscle alpha adrenoceptors in rat tail artery in vitro.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Electric Stimulation; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Yohimbine | 1984 |
RX781094 a potent and selective alpha 2-adrenergic antagonist. Effects in adipocytes and hepatocytes.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Cricetinae; Cyclic AMP; Dioxanes; Dioxins; Epinephrine; Idazoxan; In Vitro Techniques; Liver; Prazosin; Rats; Urea; Yohimbine | 1984 |
The actions of noradrenaline on neurones of the rat substantia gelatinosa in vitro.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Idazoxan; Male; Membrane Potentials; Neurons; Norepinephrine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Spinal Cord; Substantia Gelatinosa; Tetrodotoxin; Yohimbine | 1984 |
Smooth muscle alpha-2 adrenoceptors mediate vasoconstrictor responses to exogenous norepinephrine and to sympathetic stimulation to a greater extent in spontaneously hypertensive than in Wistar Kyoto rat tail arteries.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Hypertension; Idazoxan; In Vitro Techniques; Male; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Vasoconstriction | 1984 |
2-Alkyl analogue of idazoxan (RX 781094) with enhanced antagonist potency and selectivity at central alpha 2-adrenoceptors in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Dioxanes; Dioxins; Idazoxan; In Vitro Techniques; Kinetics; Male; Prazosin; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1984 |
Effects of reduced calcium ion concentration and of diltiazem on vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation in rat isolated tail artery.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Calcium; Diltiazem; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Tail; Vasoconstriction | 1984 |
Comparative effects of RX 781094, mianserin, yohimbine, rauwolscine and prazosin in reversing clonidine inhibition of MIX-stimulated lipolysis in hamster isolated white fat cells.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Clonidine; Cricetinae; Dioxanes; Epididymis; Idazoxan; In Vitro Techniques; Lipolysis; Male; Mianserin; Prazosin; Theophylline; Yohimbine | 1984 |
Characterisation of smooth muscle alpha-adrenoceptors and of responses to electrical stimulation in the cat isolated perfused middle cerebral artery.
Topics: Animals; Cats; Cerebral Arteries; Dioxins; Electric Stimulation; Female; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Vasodilator Agents | 1983 |
Alpha-2 adrenergic receptors on neurones in the region of the lateral reticular nucleus of the rat.
Topics: Animals; Clonidine; Dioxins; Evoked Potentials; gamma-Aminobutyric Acid; Humans; Idazoxan; Medulla Oblongata; Neurons; Norepinephrine; Prazosin; Rats; Receptors, Adrenergic; Reticular Formation; Synaptic Transmission | 1983 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Imidazoles; Lung; Methanol; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
Pharmacological analysis of the noradrenergic control of central sympathetic and somatic reflexes controlling the lower urinary tract in the anesthetized cat.
Topics: Anesthesia; Animals; Atomoxetine Hydrochloride; Cats; Dioxanes; Idazoxan; Motor Neurons; Norepinephrine; Prazosin; Propranolol; Propylamines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reflex; Sympathetic Nervous System; Urinary Tract | 1995 |
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Dioxanes; Drug Synergism; Formaldehyde; Hot Temperature; Idazoxan; Male; Motor Activity; Norepinephrine; Pain; Pain Measurement; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atropine; Cats; Cerebral Ventricles; Dioxanes; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Hemicholinium 3; Idazoxan; Injections, Intraventricular; Male; Mecamylamine; Methyltyrosines; Methysergide; Naloxone; Oxidopamine; Prazosin; Reserpine; Tolazoline; Tyrosine 3-Monooxygenase; Vomiting; Yohimbine | 1995 |
Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.
Topics: Actins; Adenoma, Islet Cell; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Biopolymers; Brimonidine Tartrate; Cytochalasins; Dioxanes; Drug Interactions; Exocytosis; Fluorescent Dyes; Gene Expression Regulation; Idazoxan; Insulin; Insulin Secretion; Islets of Langerhans; Neoplasm Proteins; Norepinephrine; Pertussis Toxin; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
The relationship between density of alpha-adrenoceptor binding sites and contractile responses in several porcine isolated blood vessels.
Topics: 5'-Nucleotidase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Cell Membrane; Dioxanes; Dose-Response Relationship, Drug; Drug Interactions; Ear, External; Idazoxan; Male; Microscopy, Electron; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Splenic Artery; Structure-Activity Relationship; Swine; Veins; Yohimbine | 1995 |
Effects of alpha-adrenoceptor agonists and antagonists on metabolic rate in cattle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basal Metabolism; Body Temperature; Brimonidine Tartrate; Cattle; Clonidine; Dioxanes; Female; Guanfacine; Heart Rate; Idazoxan; Male; Prazosin; Quinoxalines | 1995 |
Attenuation of arteriolar alpha 2-adrenoceptor sensitivity during endotoxemia.
Topics: Animals; Arterioles; Clonidine; Dioxanes; Endotoxins; Escherichia coli; Idazoxan; Male; Muscles; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Shock, Septic; Vasoconstriction | 1994 |
Effects of alpha-2 adrenoceptor antagonists on rough-and-tumble play in juvenile rats: evidence for a site of action independent of non-adrenoceptor imidazoline binding sites.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Agonistic Behavior; Animals; Clonidine; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Interpersonal Relations; Male; Prazosin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Drug | 1994 |
Alpha 1A-adrenoceptor subtype mediates contraction of the rat urethra.
Topics: Aminoquinolines; Animals; Calcium; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines; Urethra | 1994 |
Vasopressin inhibits food intake in pygmy goats by activation of alpha 1-adrenergic receptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Depression, Chemical; Dioxanes; Dose-Response Relationship, Drug; Eating; Female; Goats; Idazoxan; Prazosin; Propranolol; Vasopressins; Yohimbine | 1994 |
Effect of the centrally acting muscle relaxant tizanidine on spinal reflexes: involvement of descending noradrenergic systems.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Decerebrate State; Dioxanes; Hexamethonium Compounds; Idazoxan; Male; Muscle Relaxants, Central; Norepinephrine; Phentolamine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reflex; Reflex, Monosynaptic; Spinal Cord; Sympathetic Nervous System | 1993 |
Increased pressor responsiveness of femoral arteries to exogenous norepinephrine in renal hypertensive dogs mediated through alpha 2 adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Dogs; Female; Femoral Artery; Hypertension, Renal; Idazoxan; Male; Norepinephrine; Prazosin; Vasoconstriction | 1993 |
Prejunctional alpha 2-adrenoceptors inhibit acetylcholine release from cholinergic nerves in equine airways.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Trachea; Yohimbine | 1993 |
Noradrenergic modulation of gamma-aminobutyric acid outflow from the human cerebral cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Cerebral Cortex; Dioxanes; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Guinea Pigs; Humans; Idazoxan; In Vitro Techniques; Isoproterenol; Kinetics; Norepinephrine; Ouabain; Phenylephrine; Potassium; Prazosin; Rats; Species Specificity; Synaptosomes; Tetrodotoxin | 1993 |
Alpha 1 and alpha 2-adrenergic control of large and small coronary arteries during exercise in conscious dogs under beta-blockade.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Consciousness; Coronary Vessels; Dioxanes; Dogs; Heart Rate; Idazoxan; Physical Exertion; Prazosin; Propranolol; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vascular Resistance | 1993 |
Serotonin-induced contraction in canine coronary artery and saphenous vein: role of a 5-HT1D-like receptor.
Topics: 5-Methoxytryptamine; Adrenergic alpha-Antagonists; Animals; Base Sequence; Blotting, Southern; Coronary Vessels; Dioxanes; DNA Primers; Dogs; Dose-Response Relationship, Drug; Gene Expression; Idazoxan; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Polymerase Chain Reaction; Prazosin; Receptors, Serotonin; RNA, Messenger; Saphenous Vein; Serotonin; Serotonin Receptor Agonists; Sumatriptan; Tryptamines | 1994 |
Alpha 2-adrenoceptor binding sites vary along the length of the male reproductive tract: a possible basis for the regional variation in response to field stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Electric Stimulation; Epididymis; Idazoxan; In Vitro Techniques; Male; Membranes; Muscle Contraction; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vas Deferens; Yohimbine | 1994 |
Similar ligand binding in recombinant human alpha 2 C2-adrenoceptors produced in mammalian, insect and yeast cells.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cells, Cultured; Chlorpromazine; Dioxanes; Humans; Idazoxan; Immunoblotting; Mammary Neoplasms, Experimental; Mice; Molecular Sequence Data; Moths; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Recombinant Proteins; Saccharomyces cerevisiae; Transfection; Tumor Cells, Cultured; Yohimbine | 1994 |
Central and renal I1 imidazoline preferring receptors: two unique sites mediating natriuresis in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Dioxanes; Drug Interactions; Idazoxan; Imidazoles; Imidazoline Receptors; Infusions, Intravenous; Injections, Intraventricular; Male; Natriuresis; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1994 |
Acute stress-induced hyperinsulinemia in the pertussis toxin-treated rat: possible role of humoral beta-cell-tropic factors.
Topics: Acute Disease; Adrenal Medulla; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Blood Glucose; Culture Techniques; Dioxanes; Hyperinsulinism; Idazoxan; Insulin; Islets of Langerhans; Male; Peptide Fragments; Pertussis Toxin; Prazosin; Rats; Rats, Sprague-Dawley; Stress, Physiological; Virulence Factors, Bordetella; Yohimbine | 1994 |
Strychnine-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipramine; Male; Mice; Pargyline; Phentolamine; Prazosin; Propranolol; Receptors, Adrenergic; Reserpine; Seizures; Strychnine | 1994 |
Noradrenergic alpha-1 and alpha-2 antagonists block L-dopa-induced air-stepping in neonatal rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Dioxanes; Female; Idazoxan; Levodopa; Locomotion; Male; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1994 |
pKI values of prazosin and idazoxan for receptors stimulated by neuronally released transmitter in the epididymal portion of rat isolated vas deferens.
Topics: Adenosine Triphosphate; Animals; Binding, Competitive; Corticosterone; Desipramine; Dioxanes; Epididymis; Idazoxan; In Vitro Techniques; Male; Mathematics; Norepinephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Vas Deferens | 1994 |
On the characterization of dopamine-induced contractile response of rat anococcygeus muscle preparation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Azepines; Benzazepines; Desipramine; Dioxanes; Dopamine; Female; Haloperidol; Idazoxan; Male; Muscle Contraction; Prazosin; Rats; Receptors, Adrenergic; Receptors, Dopamine; Reserpine; Sulpiride; Yohimbine | 1994 |
Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dopamine; Idazoxan; In Vitro Techniques; Male; Neural Pathways; Neurons; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Reserpine; Tegmentum Mesencephali | 1993 |
In vivo pharmacological profile of SL 84.0418, a new selective, peripherally active alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Epinephrine; Heart Rate; Hyperglycemia; Idazoxan; Indoles; Male; Mice; Motor Activity; Norepinephrine; Peripheral Nerves; Prazosin; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasoconstriction | 1993 |
Clonidine-induced place preference is mediated by alpha 2-adrenoceptors outside the locus coeruleus.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Animal; Clonidine; Conditioning, Psychological; Dextroamphetamine; Dioxanes; Drug Interactions; Idazoxan; Injections, Intraperitoneal; Locus Coeruleus; Male; Oxidopamine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1993 |
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Droxidopa; Drug Synergism; Idazoxan; Imipramine; Male; Methyltyrosines; Mice; Norepinephrine; Pargyline; Phentolamine; Physostigmine; Prazosin; Reserpine; Seizures; Serotonin | 1993 |
Inhibitory influence of sympathetic nerves on afferent nerve-induced extravasation in the rat incisor pulp upon direct electrical stimulation of the tooth.
Topics: Animals; Capillary Permeability; Dental Pulp; Dioxanes; Electric Stimulation; Evans Blue; Idazoxan; Laser-Doppler Flowmetry; Male; Neurons, Afferent; Phenoxybenzamine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sympathectomy; Sympathetic Nervous System; Vasomotor System | 1993 |
Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Corpus Striatum; Dioxanes; Hippocampus; Idazoxan; Imidazoles; Male; Mianserin; Mirtazapine; Norepinephrine; Prazosin; Rats; Rats, Wistar; Serotonin; Tetrodotoxin | 1996 |
Comparative effects of idazoxan, prazosin, and yohimbine on coronary ligation-induced arrhythmias in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Coronary Vessels; Hemodynamics; Idazoxan; Ligation; Male; Prazosin; Rats; Rats, Inbred SHR; Yohimbine | 1996 |
Low concentrations of angiotensin II unmask vasoconstrictory alpha 2-adrenoceptors in isolated perfused kidneys of spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Brimonidine Tartrate; Dioxanes; Dose-Response Relationship, Drug; Hypertension; Idazoxan; Imidazoles; Kidney; Methoxamine; Perfusion; Prazosin; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction | 1995 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholinergic Fibers; Duodenum; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Medetomidine; Muscle Contraction; Nordefrin; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Membranes; Vasoconstrictor Agents; Xylazine; Yohimbine | 1996 |
Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes.
Topics: Animals; Buffers; CHO Cells; Cricetinae; Humans; Idazoxan; Kinetics; Opossums; Oxymetazoline; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Species Specificity; Yohimbine | 1996 |
SDZ NVI 085, an alpha 1A-adrenoceptor agonist with 5-HT2A receptor antagonist properties.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bridged-Ring Compounds; Idazoxan; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Regional Blood Flow; Serotonin Antagonists; Tail | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine | 1996 |
Blockade of alpha-2 adrenergic receptors in the rostral ventrolateral medulla attenuates the sympathoinhibitory response to cocaine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Pressure; Cocaine; Idazoxan; Male; Medulla Oblongata; Microinjections; Piperoxan; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sympatholytics | 1996 |
Characterization of adrenoceptor types and subtypes in American bullfrogs acclimated to warm or cold temperature.
Topics: Acclimatization; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Humans; Idazoxan; Kidney; Membrane Proteins; Myocardium; Pindolol; Prazosin; Radioligand Assay; Rana catesbeiana; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Spinal Cord; Temperature | 1996 |
Alpha-adrenergic receptor antagonism and N-methyl-D-aspartate (NMDA) induced luteinizing hormone release in female rhesus macaques.
Topics: Adrenergic alpha-Antagonists; Animals; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Idazoxan; Immunohistochemistry; In Situ Hybridization; Locus Coeruleus; Luteal Phase; Luteinizing Hormone; Macaca mulatta; N-Methylaspartate; Prazosin; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tyrosine 3-Monooxygenase | 1997 |
Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
Topics: Adrenergic alpha-Agonists; Animals; Body Water; Brimonidine Tartrate; Guanfacine; Idazoxan; Kidney; Male; Naltrexone; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1997 |
Contribution of alpha-adrenoceptors to depolarization and contraction evoked by continuous asynchronous sympathetic nerve activity in rat tail artery.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Calcium Channel Blockers; Ciguatoxins; Female; Idazoxan; Membrane Potentials; Muscle Contraction; Nifedipine; Phenylephrine; Prazosin; Rats; Receptors, Adrenergic, alpha; Tail | 1997 |
The differential involvement of adrenoceptors in challenges of different intensities.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Berberine; Electroshock; Exploratory Behavior; Idazoxan; Male; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 1996 |
Alpha-adrenoceptors in equine digital veins: evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Binding, Competitive; Brimonidine Tartrate; Dopamine; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Veins; Yohimbine | 1997 |
Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat.
Topics: Adrenergic Uptake Inhibitors; Animals; Cyclobutanes; Eating; Idazoxan; Male; Metoprolol; Prazosin; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors | 1997 |
Participation of both adrenergic and opioidergic systems in the negative feedback of adrenal progesterone on LH secretion.
Topics: Adrenal Glands; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Estradiol; Feedback; Female; Hormone Antagonists; Idazoxan; Luteinizing Hormone; Metoprolol; Mifepristone; Naloxone; Ovariectomy; Prazosin; Progesterone; Propanolamines; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Opioid | 1997 |
Alpha 2-adrenergic autoreceptors in A5 and A6 neurons of neonate rats.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Brain; Idazoxan; In Vitro Techniques; Locus Coeruleus; Meglumine; Membrane Potentials; Neurons; Norepinephrine; Potassium; Potassium Channels; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Sodium; Tetrodotoxin | 1997 |
The mechanism of action of alpha 2 adrenoceptor blockers as revealed by effects on open field locomotion and escape reactions in the shuttle-box.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Dose-Response Relationship, Drug; Escape Reaction; Idazoxan; Male; Motor Activity; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Wistar | 1997 |
Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Hydroxyindoleacetic Acid; Idazoxan; Male; Piperazines; Prazosin; Pyridines; Raclopride; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Risperidone; Salicylamides; Serotonin; Serotonin Antagonists | 1997 |
Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Cerebral Cortex; Chromatography, High Pressure Liquid; Coma; Dopamine; Frontal Lobe; Hippocampus; Hypothalamus; Idazoxan; Liver Failure, Acute; Microdialysis; Norepinephrine; Pindolol; Prazosin; Propanolamines; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Serotonin; Thalamus | 1998 |
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Anticonvulsants; Desipramine; Drug Interactions; Epilepsy; Female; Fluoxetine; Idazoxan; Methoxamine; Microinjections; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Superior Colliculi; Synaptic Transmission | 1998 |
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Dopamine; Dopamine Agonists; Frontal Lobe; Guanabenz; Guinea Pigs; Homeostasis; Idazoxan; Imidazoles; Indoles; Isoindoles; Male; Medetomidine; Models, Neurological; Motor Activity; Norepinephrine; Oxadiazoles; Piperazines; Prazosin; Raclopride; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Serotonin | 1998 |
Antinociception produced by microinjection of morphine in the rat periaqueductal gray is enhanced in the foot, but not the tail, by intrathecal injection of alpha1-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Behavior, Animal; Dioxanes; Female; Foot; Idazoxan; Injections, Spinal; Microinjections; Morphine; Narcotics; Nociceptors; Pain; Periaqueductal Gray; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Spinal Cord; Tail | 1998 |
Prejunctional alpha2A-autoreceptors in the human gastric and ileocolic arteries.
Topics: Adrenergic alpha-Antagonists; Aged; Arteries; Autoreceptors; Colon; Dioxanes; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastric Mucosa; Humans; Idazoxan; Ileum; In Vitro Techniques; Male; Middle Aged; Neuromuscular Junction; Norepinephrine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha-2; Spiro Compounds; Stomach; Tritium; Yohimbine | 1998 |
Imidazoline receptor mediated natriuresis: central and/or peripheral effect?
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antihypertensive Agents; Brain; Idazoxan; Imidazoles; Imidazoline Receptors; Injections; Injections, Intravenous; Injections, Intraventricular; Kidney; Male; Natriuresis; Peripheral Nervous System; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reserpine; Sodium; Sympathectomy | 1998 |
Autoradiographic study of alpha1- and alpha2-noradrenergic and serotonin1A receptors in the spinal cord of normal and chronically transected cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Autoradiography; Cats; Denervation; Idazoxan; Isomerism; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reference Values; Serotonin Receptor Agonists; Spinal Cord | 1999 |
Modulation of external pancreatic secretion by endogenous norepinephrine: study with a norepinephrine uptake blocker in the rat.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Deoxyglucose; Electric Stimulation; Fluoxetine; Idazoxan; Kinetics; Male; Norepinephrine; Pancreas; Prazosin; Propranolol; Rats; Rats, Wistar; Vagus Nerve; Yohimbine | 1999 |
Clonidine evokes vasodepressor responses via alpha2-adrenergic receptors in gigantocellular reticular formation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Depression, Chemical; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Idazoxan; Male; Medulla Oblongata; Microinjections; Neurons; Prazosin; Rats; Rats, Sprague-Dawley; Reticular Formation | 1999 |
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanfacine; Humans; Idazoxan; Isoquinolines; Neuroblastoma; Oxymetazoline; Piperazines; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Yohimbine | 1999 |
Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Idazoxan; Male; Norepinephrine; Oxadiazoles; Piperazines; Prazosin; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Venlafaxine Hydrochloride | 1999 |
Effects of some imidazolidine alpha2-adrenoceptor agonists in rat isolated atria.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Electric Stimulation; Female; Heart Atria; Heart Rate; Idazoxan; Imidazoles; In Vitro Techniques; Muscle Contraction; Norepinephrine; Pargyline; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors | 1999 |
Characterization of alpha-adrenoceptor subtypes in the corpus cavernosum of patients undergoing sex change surgery.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Disorders of Sex Development; Dose-Response Relationship, Drug; Humans; Idazoxan; Male; Penis; Prazosin; Receptors, Adrenergic, alpha; Sulfonamides; Tamsulosin | 1999 |
Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Basal Ganglia; Brain Stem; Cerebral Cortex; Disease Models, Animal; Female; Fluoxetine; Hypothalamus; Idazoxan; Limbic System; Mice; Mice, Neurologic Mutants; Norepinephrine; Prazosin; Propanolamines; Purkinje Cells; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Spinocerebellar Degenerations; Thalamus; Tritium | 1999 |
Synthesis and alpha-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Idazoxan; Imidazoles; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Spectrophotometry, Infrared; Yohimbine | 2000 |
Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Bicuculline; Brimonidine Tartrate; Idazoxan; Mastication; Motor Neurons; N-Methylaspartate; Neural Pathways; Norepinephrine; Organ Culture Techniques; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Trigeminal Nuclei | 2000 |
Posttraining infusion of norepinephrine and corticotropin releasing factor into the bed nucleus of the stria terminalis enhanced retention in an inhibitory avoidance task.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Avoidance Learning; Corticotropin-Releasing Hormone; Electroshock; Idazoxan; Lidocaine; Locomotion; Male; Memory; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Wistar; Reflex, Startle; Septal Nuclei | 2001 |
Endogenous adrenergic control of reflexes evoked by mechanical stimulation of the heel in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Azocines; Blood Pressure; Decerebrate State; Female; Idazoxan; Injections, Spinal; Male; Mechanoreceptors; Motor Neurons; Muscle, Skeletal; Narcotic Antagonists; Neural Inhibition; Neurons, Afferent; Norepinephrine; Physical Stimulation; Prazosin; Rabbits; Receptors, Adrenergic, alpha-2; Reflex; Spinal Cord | 2001 |
Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Gene Expression Regulation; Guanfacine; Hypertension; Idazoxan; Kidney; Male; Orchiectomy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; RNA, Messenger; Sodium Chloride; Testosterone | 2002 |
Mechanisms involved in the water intake-related pressor response in the rat.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Brazil; Diazepam; Dose-Response Relationship, Drug; Drinking; Heart Rate; Idazoxan; Lidocaine; Losartan; Male; Mecamylamine; Models, Animal; Muscle Relaxants, Central; Prazosin; Quinine; Rats; Rats, Wistar; Sodium Chloride; Tropanes; Water | 2002 |
Inhibition of pilocarpine-induced salivation in rats by central noradrenaline.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Idazoxan; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Norepinephrine; Pilocarpine; Prazosin; Rats; Rats, Sprague-Dawley; Saliva; Salivation; Statistics as Topic; Yohimbine | 2002 |
Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina.
Topics: Administration, Intravaginal; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Drug Therapy, Combination; Female; Idazoxan; In Vitro Techniques; Isometric Contraction; Ligands; Muscle, Smooth, Vascular; Oxyhemoglobins; Prazosin; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Sexual Behavior; Vagina; Vasodilator Agents | 2002 |
Central alpha(2) adrenergic receptors and cholinergic-induced salivation in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Idazoxan; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Pilocarpine; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Salivation; Sympatholytics; Yohimbine | 2003 |
Nandrolone treatment decreases the level of rat kidney alpha(1B)-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anabolic Agents; Animals; Idazoxan; Injections, Intramuscular; Kidney; Ligands; Male; Nandrolone; Prazosin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spleen | 2003 |
Sympathetic mechanisms in cerebral blood flow alterations induced by spinal cord stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cerebrovascular Circulation; Electric Stimulation; Ganglionic Blockers; Hemodynamics; Hexamethonium; Idazoxan; Injections, Intravenous; Laser-Doppler Flowmetry; Male; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta-1; Spinal Cord; Sympathetic Nervous System | 2003 |
Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Autonomic Dysreflexia; Chronic Disease; Clonidine; Electric Stimulation; Female; Idazoxan; In Vitro Techniques; Phenylephrine; Potassium; Prazosin; Rats; Rats, Wistar; Spinal Cord Injuries; Tail; Vasoconstriction | 2004 |
[Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Autoradiography; Binding Sites; Binding, Competitive; Cerebral Cortex; Idazoxan; In Vitro Techniques; Isoquinolines; Ligands; Mice; Mice, Knockout; Naphthyridines; Oxymetazoline; Phentolamine; Prazosin; Putamen; Radioligand Assay; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 2004 |
The role of alpha1- and alpha2-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus.
Topics: Adrenergic alpha-Antagonists; Animals; Biogenic Monoamines; Cyclohexanols; Dopamine; Drug Interactions; Hippocampus; Idazoxan; Male; Norepinephrine; Prazosin; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors; Venlafaxine Hydrochloride | 2004 |
Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzylamines; Brain; Cyclopropanes; Dopamine; Dose-Response Relationship, Drug; Fenclonine; Flumazenil; Fluorobenzenes; Idazoxan; Indoles; Ketanserin; Male; Mice; Milnacipran; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phenols; Prazosin; Punishment; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists | 2005 |
Sympathetic activation and tachycardia in lipopolysaccharide treated rats are temporally correlated and unrelated to the baroreflex.
Topics: Adrenergic alpha-Antagonists; Animals; Baroreflex; Blood Pressure; Denervation; Drug Interactions; Endotoxemia; Heart Rate; Idazoxan; Lipopolysaccharides; Male; Prazosin; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Sympathetic Nervous System; Tachycardia | 2005 |
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction | 2005 |
Ontogenesis of mRNA levels and binding sites of hepatic alpha-adrenoceptors in young cattle.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Binding, Competitive; Blood Glucose; Cattle; Female; Glycogen; Idazoxan; Liver; Phosphoenolpyruvate; Prazosin; Pregnancy; Pyruvate Carboxylase; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dendrites; Female; Fluoxetine; Hippocampus; Humans; Idazoxan; In Situ Hybridization; Lewy Body Disease; Locus Coeruleus; Male; Middle Aged; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tetralones; Tyrosine 3-Monooxygenase | 2006 |
Role of CNS alpha1-adrenoceptor activity in central fos responses to novelty.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain Chemistry; Central Nervous System; Dialysis; Exploratory Behavior; Idazoxan; Immunohistochemistry; Male; Oncogene Proteins v-fos; Phenylephrine; Prazosin; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 2006 |
Analysis of brain adrenergic receptors in dopamine-beta-hydroxylase knockout mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Dopamine beta-Hydroxylase; Gene Expression Regulation, Developmental; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Isotopes; Mice; Mice, Inbred C57BL; Mice, Knockout; Pindolol; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2006 |
Alpha-noradrenergic receptors modulate the development and expression of cocaine sensitization.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Cocaine; Idazoxan; Male; Motor Activity; Prazosin; Rats; Rats, Sprague-Dawley; Time Factors; Yohimbine | 2006 |
Presynaptic alpha-adrenoceptors in median preoptic nucleus modulate inhibitory neurotransmission from subfornical organ and organum vasculosum lamina terminalis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cells, Cultured; Hypothalamus; Idazoxan; Imidazoles; Isoproterenol; Norepinephrine; Prazosin; Preoptic Area; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Signal Transduction; Subfornical Organ | 2007 |
Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Dementia; Female; Gene Expression Regulation; Humans; Idazoxan; Male; Middle Aged; Postmortem Changes; Prazosin; Prefrontal Cortex; Receptors, Adrenergic; RNA, Messenger | 2007 |
Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Diuresis; Drinking; Idazoxan; Male; Microinjections; Natriuresis; Norepinephrine; Phenylephrine; Potassium; Prazosin; Raphe Nuclei; Rats; Rats, Wistar; Sodium; Urine; Water-Electrolyte Balance | 2007 |
Role of alpha1- and alpha2-adrenoceptors in the regulation of locomotion and spatial behavior in the active place avoidance task: a dose-response study.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Idazoxan; Male; Memory Disorders; Motor Activity; Prazosin; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Space Perception | 2008 |
Effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on sneeze-induced urethral continence reflex in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Duloxetine Hydrochloride; Female; Idazoxan; Methiothepin; Prazosin; Pressure; Rats; Rats, Sprague-Dawley; Reflex; Selective Serotonin Reuptake Inhibitors; Sneezing; Thiophenes; Urethra; Urinary Incontinence, Stress; Vagina | 2008 |
Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; Idazoxan; Male; Mice; Mice, Knockout; Motor Activity; Prazosin; Propanolamines; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Synapses | 2009 |
Activation of alpha(2)-adrenoceptors in the lateral hypothalamus reduces pilocarpine-induced salivation in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Hypothalamic Area, Lateral; Idazoxan; Imidazoles; Male; Muscarinic Agonists; Norepinephrine; Pilocarpine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Salivation | 2009 |
Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Attention; Discrimination, Psychological; Drug Evaluation, Preclinical; Drug Interactions; Feeding Behavior; Idazoxan; Impulsive Behavior; Male; Morpholines; Norepinephrine Plasma Membrane Transport Proteins; Prazosin; Rats; Rats, Sprague-Dawley; Reaction Time; Reboxetine; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spatial Behavior; Time Perception | 2009 |
Investigation of the distribution and function of alpha-adrenoceptors in the sheep isolated internal anal sphincter.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anal Canal; Animals; Antibodies, Monoclonal; Autoradiography; Binding, Competitive; Dose-Response Relationship, Drug; Fecal Incontinence; Humans; Idazoxan; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Prazosin; Protein Binding; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Sheep | 2010 |
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Chromones; Clonidine; Excitatory Postsynaptic Potentials; Female; Idazoxan; Models, Animal; Motor Neurons; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Sensory Receptor Cells; Spasm; Spinal Cord Injuries; Synaptic Transmission | 2011 |
Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amides; Analgesia; Anesthetics, Local; Animals; Behavior, Animal; Colforsin; Cyclic Nucleotide-Gated Cation Channels; Dexmedetomidine; Dose-Response Relationship, Drug; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Hypnotics and Sedatives; Idazoxan; Male; Nerve Block; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Prazosin; Pyrimidines; Rats; Rats, Sprague-Dawley; Ropivacaine; Sciatic Nerve | 2011 |
Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Drug Interactions; Ethanolamines; Idazoxan; Male; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Thymine; Vasoconstriction; Xylazine; Yohimbine | 2012 |
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Idazoxan; Male; Methoxamine; Movement; Neurons; Norepinephrine; Nucleus Accumbens; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2012 |
Effects of lisdexamfetamine in a rat model of binge-eating.
Topics: Animals; Baclofen; Behavior, Animal; Benzazepines; Benzodiazepines; Body Weight; Bulimia; Disease Models, Animal; Eating; Feeding Behavior; Female; Idazoxan; Lisdexamfetamine Dimesylate; Naltrexone; Olanzapine; Prazosin; Prodrugs; Raclopride; Rats; Rats, Wistar; Rolipram | 2015 |
Interdependent adrenergic receptor regulation of Arc and Zif268 mRNA in cerebral cortex.
Topics: Adrenergic Antagonists; Animals; Cerebral Cortex; Cytoskeletal Proteins; Early Growth Response Protein 1; Idazoxan; Nerve Tissue Proteins; Prazosin; Propranolol; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; RNA, Messenger | 2016 |
Noradrenaline Improves Behavioral Contrast Sensitivity via the β-Adrenergic Receptor.
Topics: Animals; Contrast Sensitivity; Idazoxan; Locus Coeruleus; Male; Norepinephrine; Photic Stimulation; Prazosin; Propranolol; Rats; Rats, Long-Evans; Receptors, Adrenergic, beta | 2016 |
Noradrenergic signaling in the VTA modulates cocaine craving.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Craving; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Idazoxan; Male; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Self Administration; Ventral Tegmental Area | 2018 |
Noradrenergic modulation determines respiratory network activity during temperature changes in the in vitro brainstem of bullfrogs.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Brain Stem; Female; Idazoxan; In Vitro Techniques; Motor Neurons; Norepinephrine; Prazosin; Rana catesbeiana; Respiration; Spinal Cord; Temperature | 2018 |
Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Antineoplastic Agents; Cold Temperature; Hyperalgesia; Idazoxan; Melitten; Neurons; Oxaliplatin; Peripheral Nervous System Diseases; Prazosin; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spinal Cord; Touch | 2019 |