idazoxan has been researched along with guanfacine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (28.57) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 4 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Agbaba, D; Filipic, S; Nikolic, K | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Uhlén, S; Wikberg, JE | 1 |
| Arnsten, AF; Leslie, FM | 1 |
| Brown, MJ; di Silvio, L; Struthers, AD | 1 |
| Coupry, I; Koenig, E; Lachaud, V; Parini, A; Podevin, RA | 2 |
| Bidet, M; Coupry, I; Lachaud, V; Parini, A; Podevin, RA; Poujeol, P | 1 |
| Näsström, J; Post, C; Uhlén, S; Wikberg, JE | 1 |
| Brown, MJ; Burrin, JM; Di Silvio, L; Ghatei, M; Struthers, AD; Yeo, T | 1 |
| Brown, DC; Brown, MJ; Burrin, JM; Di Silvio, L; Struthers, AD | 1 |
| Arnsten, AF; Cai, JX; Goldman-Rakic, PS | 1 |
| Gazzola, C; Hunter, RA; Lisle, AT; Magner, T | 1 |
| Intengan, HD; Smyth, DD | 1 |
| Arnsten, AF; Franowicz, JS | 2 |
| Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L | 1 |
| Bobirnac, I; Gazi, L; Loetscher, E; Parsley, S; Schoeffter, P | 1 |
| Bisgard, GE; Herman, JK; O'Halloran, KD | 1 |
| Dausse, JP; Giudicelli, Y; Ilhami, N; Khalid, M | 1 |
| Choi, DH; Choi, SH; Chun, BG; Lee, JJ; Park, MS | 1 |
| Ji, JZ; Li, BM; Wang, M | 1 |
| McIntyre, DC; Shin, RS | 1 |
| Angst, MJ; Fresquet, N; Gobaille, S; Sandner, G; Schleef, C | 1 |
| Clark, K; Decamp, E; Schneider, JS | 1 |
2 trial(s) available for idazoxan and guanfacine
| Article | Year |
|---|---|
Peripheral alpha 2 adrenoceptor stimulation contributes to the sympatholytic effect of guanfacine in humans.
Topics: Adult; Central Nervous System; Dioxanes; Double-Blind Method; Growth Hormone; Guanfacine; Guanidines; Humans; Idazoxan; Insulin; Male; Norepinephrine; Peripheral Nerves; Phenylacetates; Receptors, Adrenergic, alpha; Synapses | 1985 |
Metabolic and haemodynamic effects of alpha 2-adrenoceptor stimulation and antagonism in man.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Pressure; Dioxanes; Dioxins; Double-Blind Method; Growth Hormone; Guanfacine; Guanidines; Humans; Idazoxan; Male; Norepinephrine; Phenylacetates; Random Allocation; Stimulation, Chemical | 1985 |
26 other study(ies) available for idazoxan and guanfacine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
QSAR study of imidazoline antihypertensive drugs.
Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound.
Topics: Animals; Computer Simulation; Dioxanes; Guanfacine; Idazoxan; In Vitro Techniques; Isoquinolines; Kidney; Male; Monte Carlo Method; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Behavior, Animal; Blood Pressure; Brain; Brimonidine Tartrate; Cognition; Dioxanes; Female; Guanfacine; Hypnotics and Sedatives; Idazoxan; Macaca mulatta; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical; Yohimbine | 1991 |
Different affinities of alpha 2-agonists for imidazoline and alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Guanfacine; Guanidine; Guanidines; Idazoxan; Imidazoline Receptors; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine; Yohimbine | 1989 |
[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Guanfacine; Guanidines; Idazoxan; Kidney Tubules, Proximal; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Yohimbine | 1989 |
[Interaction of rilmenidine with renal imidazoline-guanidine sites].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basement Membrane; Binding Sites; Dioxanes; Drug Interactions; Guanfacine; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Drug; Rilmenidine; Sodium Channels; Yohimbine | 1989 |
Guanfacine inhibits excitatory amino acid release from rat cerebral cortex through a non-adrenergic mechanism.
Topics: Amino Acids; Animals; Aspartic Acid; Autonomic Nervous System; Cerebral Cortex; Dioxanes; Glutamates; Guanfacine; Guanidines; Idazoxan; In Vitro Techniques; Male; Phenylacetates; Prazosin; Rats; Rats, Inbred Strains; Veratridine | 1989 |
The physiological and pharmacological role of presynaptic alpha- and beta-adrenoceptors in man.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Dioxanes; Guanfacine; Guanidines; Heart Rate; Humans; Idazoxan; Insulin; Male; Norepinephrine; Phenylacetates; Propanolamines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Neurotransmitter | 1985 |
The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Azepines; Dioxanes; Dose-Response Relationship, Drug; Female; Guanfacine; Guanidines; Hypnotics and Sedatives; Hypotension; Idazoxan; Macaca mulatta; Memory; Phenylacetates; Receptors, Adrenergic, alpha | 1988 |
Effects of alpha-adrenoceptor agonists and antagonists on metabolic rate in cattle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basal Metabolism; Body Temperature; Brimonidine Tartrate; Cattle; Clonidine; Dioxanes; Female; Guanfacine; Heart Rate; Idazoxan; Male; Prazosin; Quinoxalines | 1995 |
Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
Topics: Adrenergic alpha-Agonists; Animals; Body Water; Brimonidine Tartrate; Guanfacine; Idazoxan; Kidney; Male; Naltrexone; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1997 |
The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Guanfacine; Hypnotics and Sedatives; Idazoxan; Macaca mulatta; Memory; Psychomotor Performance | 1998 |
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine | 1998 |
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanfacine; Humans; Idazoxan; Isoquinolines; Neuroblastoma; Oxymetazoline; Piperazines; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Yohimbine | 1999 |
Alpha2A-adrenoceptor mediated tachypnea in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Goats; Guanfacine; Heart Rate; Idazoxan; Periodicity; Receptors, Adrenergic, alpha-2; Respiratory Mechanics | 2001 |
Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Gene Expression Regulation; Guanfacine; Hypertension; Idazoxan; Kidney; Male; Orchiectomy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; RNA, Messenger; Sodium Chloride; Testosterone | 2002 |
Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes.
Topics: Acridine Orange; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Antineoplastic Agents; Apoptosis; Astrocytes; Cathepsin D; Cell Division; Cell Line; Cerebral Cortex; Cytochrome c Group; Fish Venoms; Guanabenz; Guanfacine; HIV Protease Inhibitors; Idazoxan; Imidazoles; Indoles; Isoindoles; L-Lactate Dehydrogenase; Ligands; Lysosomes; Membrane Potentials; Mitochondria; Naphthoquinones; Neuroglia; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Drug | 2002 |
Actions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cognition; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanfacine; Hypotension; Idazoxan; Macaca mulatta; Memory; Quinolizines; Receptors, Adrenergic, alpha-2 | 2002 |
The alpha(2A)-adrenergic agonist guanfacine improves visuomotor associative learning in monkeys.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Association Learning; Behavior, Animal; Discrimination Learning; Dose-Response Relationship, Drug; Guanfacine; Idazoxan; Macaca mulatta; Photic Stimulation; Psychomotor Performance; Statistics, Nonparametric | 2004 |
Differential noradrenergic influence on seizure expression in genetically Fast and Slow kindling rat strains during massed trial stimulation of the amygdala.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amygdala; Analysis of Variance; Animals; Dose-Response Relationship, Radiation; Drug Administration Schedule; Electric Stimulation; Guanfacine; Idazoxan; Kindling, Neurologic; Norepinephrine; Rats; Reaction Time; Seizures | 2007 |
Adrenergic drugs modify the level of noradrenaline in the insular cortex and alter extinction of conditioned taste aversion in rats.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Avoidance Learning; Blood Glucose; Cerebral Cortex; Conditioning, Classical; Drinking Behavior; Extinction, Psychological; Guanfacine; Idazoxan; Male; Microdialysis; Norepinephrine; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha-2; Taste | 2007 |
Effects of the alpha-2 adrenoceptor agonist guanfacine on attention and working memory in aged non-human primates.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Attention; Cognition; Dose-Response Relationship, Drug; Guanfacine; Idazoxan; Macaca mulatta; Male; Memory, Short-Term; Psychomotor Performance; Reaction Time; Space Perception | 2011 |