idazoxan has been researched along with clozapine in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bunney, BS; Chiodo, LA | 1 |
| Hong, WW; Hsiao, JK; Litman, RE; Pickar, D; Potter, WZ; Su, TP; Weissman, EM | 1 |
| Hong, WW; Litman, RE; Pickar, D; Potter, WZ; Su, TP | 1 |
| Hertel, P; Nomikos, GG; Svensson, TH | 1 |
| McAllister, KH; Rey, B | 1 |
| Grottick, AJ; Herberg, LJ; Montgomery, AM | 1 |
| Dean, B | 1 |
| Hertel, P; Jardemark, KE; Langlois, X; Marcus, MM; Svensson, TH; Wadenberg, ML | 1 |
| Ball, GF; Castelino, CB; Cornil, CA | 1 |
| Chau, DT; Dawson, R; Green, AI; Khokhar, JY | 1 |
2 trial(s) available for idazoxan and clozapine
| Article | Year |
|---|---|
Clinical response to clozapine in patients with schizophrenia.
Topics: Clozapine; Dioxanes; Double-Blind Method; Drug Therapy, Combination; Fluphenazine; Hospitalization; Humans; Idazoxan; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1994 |
Idazoxan and response to typical neuroleptics in treatment-resistant schizophrenia. Comparison with the atypical neuroleptic, clozapine.
Topics: Adrenergic alpha-Antagonists; Adult; Antipsychotic Agents; Clozapine; Dioxanes; Double-Blind Method; Drug Therapy, Combination; Female; Fluphenazine; Humans; Idazoxan; Imidazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 1996 |
12 other study(ies) available for idazoxan and clozapine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons.
Topics: Anesthetics; Animals; Antipsychotic Agents; Biomechanical Phenomena; Chloral Hydrate; Clozapine; Dibenzazepines; Dioxanes; Dopamine; Drug Combinations; Haloperidol; Idazoxan; Male; Mesencephalon; Neurons; Prazosin; Rats; Rats, Inbred Strains; Trihexyphenidyl | 1985 |
Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Hydroxyindoleacetic Acid; Idazoxan; Male; Piperazines; Prazosin; Pyridines; Raclopride; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Risperidone; Salicylamides; Serotonin; Serotonin Antagonists | 1997 |
Clozapine reversal of the deficits in coordinated movement induced by D2 receptor blockade does not depend upon antagonism of alpha2 adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Ataxia; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Idazoxan; Loxapine; Male; Muscarinic Antagonists; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Scopolamine; Yohimbine | 1999 |
Rapid recovery of self-stimulation responding from depression by clozapine is prevented by the alpha 2-adrenoceptor agonist, clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Antipsychotic Agents; Clonidine; Clozapine; Depression; Dose-Response Relationship, Drug; Electric Stimulation; Idazoxan; Male; Rats; Risperidone; Self Stimulation; Tegmentum Mesencephali | 1999 |
[3H]RX 821002 in human dorsolateral prefrontal cortex: no changes in postmortem tissue from subjects with schizophrenia.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Aged; Benzodiazepines; Binding Sites; Clozapine; Female; Hippocampus; Humans; Idazoxan; Male; Middle Aged; Olanzapine; Postmortem Changes; Prefrontal Cortex; Schizophrenia; Serotonin Antagonists | 2003 |
Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Cerebral Cortex; Clozapine; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Idazoxan; In Vitro Techniques; Male; Maze Learning; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Synaptic Transmission | 2005 |
Dopamine binds to alpha(2)-adrenergic receptors in the song control system of zebra finches (Taeniopygia guttata).
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clozapine; Dopamine; Finches; Haloperidol; Homeostasis; Idazoxan; Male; Raclopride; Receptors, Adrenergic, alpha-2; Vocalization, Animal | 2008 |
Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Adult; Alcohol Drinking; Animals; Clozapine; Desipramine; Dose-Response Relationship, Drug; Drug Synergism; Eating; Female; Haloperidol; Humans; Idazoxan; Male; Mesocricetus; Receptors, Dopamine D2 | 2015 |