idazoxan has been researched along with benzofurans in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (7.58) | 18.7374 |
| 1990's | 26 (39.39) | 18.2507 |
| 2000's | 19 (28.79) | 29.6817 |
| 2010's | 14 (21.21) | 24.3611 |
| 2020's | 2 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Berridge, TL; Doxey, JC; Roach, AG; Smith, CF | 1 |
| Chan, SL; Morgan, NG; Stillings, MR | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Mantzourides, T; Xiang, JZ | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Hajimohammadreza, I; Mantzouridis, T; Xiang, JZ | 1 |
| Hyde, NA; Nichols, JD; Sugden, K | 1 |
| Joly, G; Mouillé, P; Schmitt, H | 1 |
| Folkow, B; Nilsson, H; Sjöblom, N | 1 |
| Alemany, R; Escribá, PV; García-Sevilla, JA; Menargues, A; Obach, R; Olmos, G | 1 |
| Berdeu, D; Bertrand, G; Gross, R; Loubatières-Mariani, MM; Puech, R | 1 |
| Haque, M; Kulkarni, RN; MacDermot, J; Olmos, G | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Scarpello, KE | 1 |
| Brown, CA; Morgan, NG | 1 |
| Starke, K; Trendelenburg, AU; Wahl, CA | 1 |
| Chan, CK; Head, GA | 1 |
| Dunne, MJ; Hashmi, MN; Kane, C; Shepherd, RM; Squires, PE | 1 |
| Steinberg, MI; Wiest, SA | 1 |
| Chapleo, CB; Grivas, K; Hudson, AL; Husbands, S; Lewis, JW; Mallard, NJ; Nutt, DJ | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Mourtada, M; Piercy, V; Smith, SA | 1 |
| Alemany, R; García-Sevilla, JA; Olmos, G | 1 |
| Cleale, RM; Hadcock, JR; Ingling, JM; Pausch, MH; Search, DJ | 1 |
| Hudson, AL; Lione, LA; Nutt, DJ | 1 |
| Boronat, MA; García-Sevilla, JA; Olmos, G | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, J | 1 |
| Martín-Ruiz, R; Pineda, J; Ruiz-Ortega, JA; Ugedo, L | 1 |
| Chopin, P; Colpaert, FC; Marien, M | 1 |
| Debowski, T; Krzystanek, E; Krzystanek, M; Saczewski, F; Trzeciak, H | 1 |
| Alemany, R; Boronat, MA; García-Sevilla, JA; Olmos, G | 1 |
| Danbury, TC; Hudson, AL; Kestin, SC; Ruban, B; Waterman-Pearson, AE | 1 |
| Chen, K; Pickard, RT; Shih, JC; Steinberg, MI; Wiest, SA | 1 |
| Artigas, F; Martín-Ruiz, R; Pineda, J; Ruiz-Ortega, JA; Ugedo, L | 1 |
| Assumpció Boronat, M; DeGregorio-Rocasolano, N; García-Sevilla, JA; Gasull, T; Lerma, J; Olmos, G; Paz Regalado, M; Trullas, R; Villarroel, A | 1 |
| Elliott, J; Morgan, NG; Mourtada, M; Smith, SA | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, JC | 1 |
| Ballesteros, J; Callado, LF; Gutiérrez, M; Maeztu, AI; Meana, JJ | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 1 |
| Hudson, AL; Nutt, DJ; Robinson, ES; Tyacke, RJ | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Dominiak, P; Häuser, W; Jungbluth, B; Raasch, W; Schäfer, U | 2 |
| Pauwels, PJ; Rauly, I; Wurch, T | 1 |
| Gao, H; Morgan, NG; Mourtada, M | 1 |
| Bleck, C; Jörns, A; Rustenbeck, I; Wienbergen, A | 1 |
| Handley, SL; MacInnes, N | 1 |
| Anderson, NJ; Hudson, AL; Lupo, PA; Nutt, DJ; Robinson, ES | 1 |
| Cambridge, N; Robinson, ES | 1 |
| Honda, M; Kino, Y; Ono, H; Tanabe, M | 1 |
| Anderson, NJ; Hudson, AL; Nutt, DJ; Robinson, ES; Seif, I | 1 |
| Cardinaletti, C; Carrieri, A; Gentili, F; Ghelfi, F; Mattioli, L; Perfumi, M; Pigini, M; Vesprini, C | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
| Han, Z; Jin, K; Shao, B; Xiao, MJ; Yang, GY; Zheng, RY | 1 |
| Han, Z; Hou, ST; Jiang, SX; Li, XL; Zeng, JQ; Zheng, RY | 1 |
| Li, JX; Winter, JC; Zhang, Y | 1 |
| Aglawe, MM; Chopde, CT; Kotagale, NR; Taksande, BG; Tripathi, SJ; Umekar, MJ | 1 |
| Athayde, ML; Boligon, AA; Bonacorso, HG; Calixto, JB; Ferreira, J; Machado, P; Martins, MA; Oliveira, SM; Rosa, F; Rossato, MF; Rubin, MA; Silva, CR; Tonello, R; Trevisan, G; Walker, CI; Zanatta, N | 1 |
| He, X; Li, JX; Qiu, Y; Thorn, DA; Zhang, Y | 1 |
| Caselli, G; Ferrari, F; Lanza, M; Menghetti, I; Tremolada, D | 1 |
| García-Sevilla, JA; Keller, B | 2 |
| Boblewski, K; Kornicka, A; Lehmann, A; Marchwińska, A; Rybczyńska, A; Sączewski, F; Sączewski, J | 1 |
| Harvey, BH; Sallinen, J; Shahid, M; Uys, MM | 1 |
| Nakamoto, M; Ohya, Y; Sakima, A; Takishita, S; Yamazato, M; Yamazato, Y | 1 |
| Bernard, R; Bernstein, HG; Laube, G; Veh, RW; Weiss, T | 1 |
| Li, JX; Seaman, RW; Shang, L; Siemian, JN; Zhang, Y; Zhu, Q | 1 |
| Aglawe, MM; Chopde, CT; Gujar, S; Khade, SD; Kotagale, NR; Taksande, BG | 1 |
| Djikic, T; Laurila, J; Nikolic, K; Radi, M; Veljkovic, N; Vucicevic, J; Xhaard, H | 1 |
| Manole, OM; Moraru, C; Nechita, P; Rusu-Zota, G; Şorodoc, V | 1 |
1 review(s) available for idazoxan and benzofurans
| Article | Year |
|---|---|
Desensitization of insulin secretion by depolarizing insulin secretagogues.
Topics: Animals; Benzofurans; Calcium; Humans; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Potassium Channels | 2004 |
65 other study(ies) available for idazoxan and benzofurans
| Article | Year |
|---|---|
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Idazoxan; Imidazoles; Insulin; Male; Muscles; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens | 1992 |
Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Diazoxide; Dioxanes; Dose-Response Relationship, Drug; Hypoglycemic Agents; Idazoxan; Imidazoles; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Phentolamine; Rats; Rats, Inbred Strains | 1991 |
Presynaptic alpha 2-adrenoceptor and kappa-opiate receptor occupancy promotes closure of neuronal (N-type) calcium channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzofurans; Calcium; Calcium Channels; Clonidine; Dioxanes; Fura-2; Idazoxan; In Vitro Techniques; Male; Mollusk Venoms; Naloxone; Neurons; Nifedipine; omega-Conotoxin GVIA; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptosomes | 1989 |
Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism?
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Caffeine; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Fluorescent Dyes; Fura-2; Homeostasis; Idazoxan; Male; Naloxone; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Purinergic; Synaptosomes | 1989 |
Determination of underivatised efaroxan and idazoxan in blood plasma by capillary gas chromatography with mass-selective detection.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Dioxanes; Dioxins; Gas Chromatography-Mass Spectrometry; Humans; Idazoxan; Imidazoles | 1989 |
Antagonistic effects of S9871 or (imidazolinyl-2)-2-dihydro 2,3 benzofurane and its stereoisomers on some central and peripheral actions of alpha 2-agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Decerebrate State; Dioxanes; Electric Stimulation; Hypnotics and Sedatives; Idazoxan; Injections, Intraventricular; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
Interaction between prejunctional alpha 2-receptors and neuronal transmitter reuptake in small mesenteric arteries from the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cocaine; Dioxanes; Electric Stimulation; Hydroxydopamines; Idazoxan; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Denervation; Muscle, Smooth, Vascular; Neuromuscular Junction; Neurotransmitter Agents; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Vascular Resistance; Yohimbine | 1985 |
LSL 60101, a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Astrocytes; Benzofurans; Brain Chemistry; Cerebral Cortex; Dioxanes; Glial Fibrillary Acidic Protein; Idazoxan; Imidazoles; Imidazoline Receptors; Immunoblotting; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; Up-Regulation | 1995 |
Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antazoline; Benzofurans; Binding, Competitive; Cimetidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Receptors, Drug; Reference Standards; Tolbutamide; Vascular Resistance | 1995 |
Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Affinity Labels; Animals; Benzofurans; Binding, Competitive; Clonidine; Clorgyline; Diazoxide; Dioxanes; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulinoma; Ligands; Pancreatic Neoplasms; Potassium Channels; Rats; Receptors, Drug; Regression Analysis; Software; Tumor Cells, Cultured | 1994 |
The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites.
Topics: Animals; Benzofurans; Binding Sites; Dioxanes; Down-Regulation; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Male; Rats; Rats, Wistar; Receptors, Drug | 1994 |
Control of insulin secretion by imidazolines in rat pancreatic islets.
Topics: Animals; Benzofurans; Diazoxide; Dioxanes; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Rats | 1993 |
Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Benzofurans; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Electric Stimulation; Female; Guinea Pigs; Idazoxan; Imidazoles; Isotope Labeling; Male; Norepinephrine; Oxathiins; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tritium | 1996 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus-response coupling of insulin release.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Calcium; Cytosol; Down-Regulation; Glucose; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Islets of Langerhans; Mice; Phentolamine; Receptors, Drug; Signal Transduction | 1996 |
Binding of [3H]2-(2-benzofuranyl)-2-imidazoline (BFI) to human brain: potentiation by tranylcypromine.
Topics: Animals; Benzofurans; Binding, Competitive; Brain; Cerebral Cortex; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kinetics; Ligands; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Receptors, Drug; Reticular Formation; Tranylcypromine | 1997 |
Identification of ligands selective for central I2-imidazoline binding sites.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Brain; Cell Membrane; Female; Idazoxan; Imidazoline Receptors; Ligands; Male; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Drug; Structure-Activity Relationship | 1997 |
Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Drug Interactions; Glyburide; Hypoglycemic Agents; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Stereoisomerism | 1997 |
Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes.
Topics: Adrenergic beta-Antagonists; Affinity Labels; Animals; Benzofurans; Binding, Competitive; Brain; Cerebral Cortex; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isoenzymes; Ligands; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1997 |
Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Area Under Curve; Benzofurans; Blood Urea Nitrogen; Fatty Acids, Nonesterified; Female; Idazoxan; Imidazoles; Isoproterenol; Male; Random Allocation; Swine | 1998 |
Characterisation and localisation of [3H]2-(2-benzofuranyl)-2-imidazoline binding in rat brain: a selective ligand for imidazoline I2 receptors.
Topics: Animals; Autoradiography; Benzofurans; Binding, Competitive; Brain; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Ligands; Male; Membranes; Rats; Rats, Wistar; Receptors, Drug; Tritium | 1998 |
Attenuation of tolerance to opioid-induced antinociception and protection against morphine-induced decrease of neurofilament proteins by idazoxan and other I2-imidazoline ligands.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Benzofurans; Brain; Drug Tolerance; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Neurofilament Proteins; Pain Measurement; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, N-Methyl-D-Aspartate | 1998 |
Neuroprotective effects of the alpha2-adrenoceptor antagonists, (+)-efaroxan and (+/-)-idazoxan, against quinolinic acid-induced lesions of the rat striatum.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Enzyme Activation; Huntington Disease; Idazoxan; Imidazoles; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
Stimulation of locus coeruleus neurons by non-I1/I2-type imidazoline receptors: an in vivo and in vitro electrophysiological study.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Diazoxide; Electrophysiology; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Ligands; Locus Coeruleus; Male; Neurons; Potassium Channels; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Vasodilator Agents | 1998 |
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Brimonidine Tartrate; Clonidine; Dopamine Agonists; Idazoxan; Imidazoles; Ligands; Male; Methylphenidate; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Stereotyped Behavior; Substantia Nigra | 1999 |
Structure of new imidazoline derivatives and their cardiovascular effect in rats.
Topics: Animals; Benzofurans; Blood Pressure; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Phenoxybenzamine; Rats; Rats, Wistar; Receptors, Drug; Structure-Activity Relationship; Yohimbine | 1999 |
Pharmacologic and molecular discrimination of I2-imidazoline receptor subtypes.
Topics: Amiloride; Animals; Benzofurans; Cell Membrane; Cerebral Cortex; Guanidine; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Monoamine Oxidase Inhibitors; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tritium | 1999 |
Imidazoline (I2) binding sites in chicken brain.
Topics: Agmatine; Amiloride; Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Chickens; Clonidine; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Receptors, Drug; Tritium | 1999 |
Binding of the imidazoline ligand 3H-2-benzofuranyl-2-imidazoline (BFI) to human brain and platelets. Potentiation by tranylcypromine and role of MAO isoforms.
Topics: Animals; Benzofurans; Blood Platelets; Brain; Cell Membrane; Cerebral Cortex; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Isoenzymes; Kinetics; Ligands; Monoamine Oxidase; Rats; Receptors, Drug; Tranylcypromine; Tritium | 1999 |
Imidazoline-induced inhibition of firing rate of 5-HT neurons in rat dorsal raphe by modulation of extracellular 5-HT levels.
Topics: Animals; Benzofurans; Clorgyline; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Neurons; Phenylephrine; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Serotonin | 1999 |
Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor.
Topics: Agmatine; Animals; Antazoline; Benzofurans; Cell Line; Cells, Cultured; Cerebellum; Dioxanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Humans; Idazoxan; Imidazoles; Neuroprotective Agents; Patch-Clamp Techniques; Potassium; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Styrenes | 1999 |
Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells.
Topics: Animals; Antazoline; Apoptosis; Benzofurans; Binding Sites; Cell Division; Cell Survival; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Islets of Langerhans; PC12 Cells; Phentolamine; Rats; Receptors, Drug | 2000 |
Drug treatments to reduce excitotoxicity in vivo: a potential for alpha2-adrenoceptor antagonists?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzofurans; Corpus Striatum; Idazoxan; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley | 2000 |
Differential [(3)H]idazoxan and [(3)H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) binding to imidazoline I(2) receptors in human postmortem frontal cortex.
Topics: Adrenergic alpha-Antagonists; Autopsy; Benzofurans; Binding, Competitive; Dose-Response Relationship, Drug; Frontal Lobe; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Membranes; Radioligand Assay; Receptors, Drug; Tritium | 2001 |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Catheterization; Clonidine; Drug Interactions; Ethanol; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2001 |
Distribution of [(3)H]BU224, a selective imidazoline I(2) binding site ligand, in rat brain.
Topics: Animals; Autoradiography; Benzofurans; Binding Sites; Binding, Competitive; Brain; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kinetics; Ligands; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Drug | 2002 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Antihypertensive Agents; Benzofurans; Binding Sites; Blood Pressure; Disease Models, Animal; Heart Rate; Idazoxan; Imidazoles; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2 | 2003 |
Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Benzopyrans; Binding Sites; Brimonidine Tartrate; CHO Cells; Cricetinae; Cyclic AMP; Epinephrine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Idazoxan; Imidazoles; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Sulfur Radioisotopes; Tumor Cells, Cultured | 2003 |
Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.
Topics: Animals; Benzofurans; Binding Sites; Cell Line; Cell Survival; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Nitric Oxide; Time Factors | 2003 |
Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds; Electric Stimulation; Heptanes; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Spinal Cord | 2003 |
Autoradiographic localisation of [3H]2-BFI imidazoline I2 binding sites in mouse brain.
Topics: Animals; Autoradiography; Benzofurans; Binding Sites; Binding, Competitive; Brain; Idazoxan; Imidazoles; Male; Mice; Mice, Inbred C57BL; Midline Thalamic Nuclei; Nucleus Accumbens; Radioligand Assay; Raphe Nuclei; Tritium | 2005 |
Characterisation of imidazoline I2 binding sites in pig brain.
Topics: Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Carbolines; Clonidine; Dose-Response Relationship, Drug; Female; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Male; Monoamine Oxidase Inhibitors; Picolinic Acids; Radioligand Assay; Receptors, Drug; Swine; Thiazoles; Tritium | 2005 |
Effect of BU98008, an imidazoline1-binding site ligand, on body temperature in mice.
Topics: Animals; Benzofurans; Binding Sites; Body Temperature; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Isoquinolines; Ligands; Male; Mice; Receptors, Drug | 2005 |
Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Adrenergic alpha-Antagonists; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Muscle Relaxants, Central; Norepinephrine; Oxidopamine; Rats; Rats, Wistar; Receptors, Drug; Reflex, Monosynaptic; Serotonin; Serotonin Agents; Spinal Cord; Sympathetic Nervous System; Time Factors | 2005 |
Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice.
Topics: Animals; Autoradiography; Benzofurans; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Epithelial Cells; Harmine; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Iodine Radioisotopes; Kidney; Mice; Mice, Inbred C3H; Mice, Knockout; Monoamine Oxidase; Neurons; Picolinic Acids; Radioligand Assay; Receptors, Drug; Thiazoles | 2006 |
Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Benzofurans; CHO Cells; Cricetinae; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mice; Models, Molecular; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Opioid, mu; Yohimbine | 2006 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |
Attenuation of ischemia-induced rat brain injury by 2-(-2-benzofuranyl)-2-imidazoline, a high selectivity ligand for imidazoline I(2) receptors.
Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Caspase 3; Disease Models, Animal; Idazoxan; Imidazoles; Imidazoline Receptors; In Situ Nick-End Labeling; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Tetrazolium Salts | 2009 |
Reversible inhibition of intracellular calcium influx through NMDA receptors by imidazoline I(2) receptor antagonists.
Topics: Animals; Benzofurans; Calcium; Cerebral Cortex; Glutamic Acid; Idazoxan; Imidazoles; Imidazoline Receptors; Intracellular Space; Mice; Molecular Imaging; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, N-Methyl-D-Aspartate | 2010 |
Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Yohimbine | 2011 |
Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test.
Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Benzofurans; Biguanides; Bupropion; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Guanidines; Idazoxan; Imidazoles; Immobility Response, Tonic; Injections, Intraventricular; Male; Mice; Motor Activity | 2013 |
A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Benzofurans; Diterpenes; Drug Administration Routes; Drug Evaluation, Preclinical; Idazoxan; Male; Mice; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrazoles; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Tritium; TRPV Cation Channels | 2013 |
Behavioral effects of the imidazoline I(2) receptor ligand BU99006 in rats.
Topics: Animals; Benzofurans; Body Temperature; Central Nervous System Agents; Discrimination, Psychological; Dose-Response Relationship, Drug; Hypothermia; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Sprague-Dawley | 2014 |
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Binding Sites; Drug Synergism; Female; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Morphine; Naloxone; Narcotic Antagonists; Pain, Postoperative; Quinazolines; Rats, Sprague-Dawley; Yohimbine | 2014 |
Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I1- and I2-imidazoline drugs.
Topics: Adult; Animals; Antibodies; Benzofurans; Binding Sites; Brain; Cell Membrane; Cytosol; Female; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Mice; Styrenes; Up-Regulation | 2015 |
Circulatory effect of TCS-80, a new imidazoline compound, in rats.
Topics: Animals; Benzofurans; Blood Pressure; Heart Rate; Hypotension; Idazoxan; Imidazoles; Imidazolidines; Imidazoline Receptors; Imidazolines; Indazoles; Male; Rats; Receptors, Adrenergic, alpha-2 | 2016 |
Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice.
Topics: Animals; Benzofurans; Cerebral Cortex; Cyclin-Dependent Kinase 5; Glutamic Acid; Hippocampus; Idazoxan; Imidazoles; Imidazoline Receptors; Kainic Acid; Ligands; Male; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Styrenes; Time Factors | 2016 |
The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Benzofurans; Cognitive Dysfunction; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Idazoxan; Imipramine; Male; Motor Activity; Quinolizidines; Rats; Swimming | 2017 |
Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Blood Pressure Determination; Clonidine; Consciousness; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 2019 |
Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex-a relevant mechanism in the pathophysiology and treatment of depression?
Topics: Action Potentials; Agmatine; Animals; Benzofurans; Depression; Female; Habenula; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Middle Aged; Neurons; Rats, Wistar; Ureohydrolases | 2018 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Reserpine | 2019 |
Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors.
Topics: Agmatine; Animals; Arginine; Benzofurans; Biguanides; Central Nervous System Sensitization; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Infusions, Intraventricular; Male; Mice; Microinjections; Motor Activity | 2019 |
Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field.
Topics: Animals; Area Under Curve; Benzofurans; CHO Cells; Cricetulus; Humans; Idazoxan; Imidazoles; Imidazolines; Ligands; Molecular Docking Simulation; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Reproducibility of Results | 2020 |
Effects of imidazoline agents in a rat conditioned place preference model of addiction.
Topics: Agmatine; Analgesics, Opioid; Animals; Benzofurans; Conditioning, Psychological; Drug Interactions; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Wistar; Time Factors; Tramadol | 2022 |