Page last updated: 2024-09-03

icrf 193 and etoposide

icrf 193 has been researched along with etoposide in 34 studies

Compound Research Comparison

Studies
(icrf 193)
Trials
(icrf 193)
Recent Studies (post-2010)
(icrf 193)
Studies
(etoposide)
Trials
(etoposide)
Recent Studies (post-2010) (etoposide)
15503018,3063,6934,900

Protein Interaction Comparison

ProteinTaxonomyicrf 193 (IC50)etoposide (IC50)
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]Homo sapiens (human)1.153
nuclear receptor coactivator 3 isoform aHomo sapiens (human)1.4284
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)3.187
Caspase-3Homo sapiens (human)1
DNA topoisomerase 2-betaHomo sapiens (human)0.4299
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)4.18

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (44.12)18.2507
2000's14 (41.18)29.6817
2010's3 (8.82)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Gobec, S; Janežič, M; Perdih, A; Pogorelčnik, B; Solmajer, T; Sosič, I1
Andoh, T; Ishida, R; Ishimi, Y1
Clarke, DJ; Creighton, AM; Downes, CS; Giménez-Abián, JF; Johnson, RT; Mullinger, AM1
Clarke, DJ; Downes, CS; Johnson, RT1
Andoh, T; Aratani, Y; Koyama, H1
Beere, HM; Chresta, CM; Hickman, JA1
Elias, P; Hammarsten, O; Yao, X1
Hayakawa, N; Hirakawa, S; Kawasaki, H; Ota, Z; Tanimoto, C1
Kramer, R; Lassota, P; Singh, G1
Aratani, Y; Fujimaki, K; Fujisawa, S; Koyama, H; Motomura, S; Okubo, T1
Cleveland, JL; Fee, BE; Hiebert, SW; Nip, J; Strom, DK; Zambetti, G1
Aller, P; Creighton, AM; de Blas, E; García-Bermejo, L; Pérez, C; Vilaboa, NE1
Andoh, T; Hamatake, M; Ishida, R1
Allan, WP; Creighton, AM; Hasinoff, BB; Kozlowska, H; Thampatty, P; Yalowich, JC1
Creighton, AM; Holm, B; Jensen, LH; Jensen, PB; Kenwrick, S; Nitiss, JL; Oliveri, RS; Sehested, M; Wessel, I1
Austin, CA; Creighton, AM; Fisher, LM; Jazrawi, E; Patel, S1
Jensen, LH; Jensen, PB; Møller, M; Nitiss, JL; Sehested, M; Wessel, I1
Kikuchi, A; Sano, K; Tokunaga, A; Tsutsui, K1
Barret, JM; Etiévant, C; Hill, BT; Kruczynski, A; van Hille, B1
Hamatake, M; Hirano, K; Iguchi, K; Ishida, R; Shibata, M; Usami, Y1
Adachi, N; Aratani, Y; Kikuchi, A; Kobayashi, M; Koyama, H1
Mondal, N; Parvin, JD1
Adachi, N; Iiizumi, S; Koyama, H; Suzuki, H1
Adachi, N; Iiizumi, S; Koyama, H; So, S1
Andreassen, PR; Lacroix, FB; Margolis, RL; Skoufias, DA; Wilson, L1
Adachi, N; Iiizumi, S; Koyama, H1
Bestor, TH; Damelin, M; Sodja, VB; Sun, YE1
Kaufmann, WK1
Grauslund, M; Hasinoff, BB; Jensen, LH; Liang, H; Sehested, M; Shoemaker, R1
Adachi, N; Ayusawa, D; Fujii, M; Iiizumi, S; Koyama, H; Kurosawa, A; Miki, K; Takayama, S1
Fan, HY; Li, XM; Liu, XM; Sun, QY; Wang, ZW; Yu, C; Zhang, YL; Zhou, D1
Jain, CK; Majumder, HK; Roychoudhury, S1
Cao, D; Dang, X; El Gazzar, M; Khanal, S; Li, Z; Moorman, JP; Morrison, ZD; Nguyen, LN; Nguyen, LNT; Ning, S; Ogbu, SC; Schank, M; Thakuri, BKC; Wang, L; Wang, Z; Wu, XY; Yao, ZQ; Zhang, J; Zhao, J1
Ekedahl, E; Hammarsten, O; Johansson, P; Lin, YL; Singh, V; Westerlund, F1

Other Studies

34 other study(ies) available for icrf 193 and etoposide

ArticleYear
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site.
    Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

    Topics: Adenosine Triphosphate; Antigens, Neoplasm; Binding Sites; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Evaluation, Preclinical; Etoposide; Humans; Molecular Docking Simulation; Molecular Structure; Protein Structure, Tertiary; Small Molecule Libraries; Topoisomerase II Inhibitors; Triazines

2015
Effect of ICRF-193, a novel DNA topoisomerase II inhibitor, on simian virus 40 DNA and chromosome replication in vitro.
    Molecular and cellular biology, 1992, Volume: 12, Issue:9

    Topics: Camptothecin; Cell Line; Chromosomes; Diketopiperazines; DNA Replication; DNA, Viral; Electrophoresis, Gel, Two-Dimensional; Etoposide; HeLa Cells; Humans; Neutralization Tests; Piperazines; Simian virus 40; Topoisomerase II Inhibitors

1992
A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.
    Nature, 1994, Dec-01, Volume: 372, Issue:6505

    Topics: Animals; Caffeine; Cell Line; Chromosomes; Diketopiperazines; DNA Damage; DNA Topoisomerases, Type II; Etoposide; G2 Phase; HeLa Cells; Humans; Mitosis; Muntjacs; Nocodazole; Piperazines; Topoisomerase II Inhibitors

1994
Topoisomerase II inhibition prevents anaphase chromatid segregation in mammalian cells independently of the generation of DNA strand breaks.
    Journal of cell science, 1993, Volume: 105 ( Pt 2)

    Topics: Anaphase; Animals; Cell Line; Diketopiperazines; DNA Damage; DNA Topoisomerases, Type II; Egtazic Acid; Etoposide; HeLa Cells; Humans; Kidney; Macropodidae; Piperazines; Topoisomerase II Inhibitors

1993
Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells.
    Mutation research, 1996, Feb-15, Volume: 362, Issue:2

    Topics: Adenine Phosphoribosyltransferase; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; Diketopiperazines; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Mutagenesis; Mutagenicity Tests; Nucleic Acid Heteroduplexes; Piperazines; Recombination, Genetic; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transfection

1996
Selective inhibition of topoisomerase II by ICRF-193 does not support a role for topoisomerase II activity in the fragmentation of chromatin during apoptosis of human leukemia cells.
    Molecular pharmacology, 1996, Volume: 49, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Diketopiperazines; DNA Damage; Enzyme Inhibitors; Etoposide; Formamides; HL-60 Cells; Humans; Piperazines; Topoisomerase II Inhibitors

1996
Inhibition of topoisomerase II by ICRF-193 prevents efficient replication of herpes simplex virus type 1.
    Journal of virology, 1996, Volume: 70, Issue:7

    Topics: Animals; Cell Line; Cell Line, Transformed; Chlorocebus aethiops; Cricetinae; Diketopiperazines; DNA Helicases; DNA Primase; DNA Replication; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA-Directed DNA Polymerase; DNA, Viral; Enzyme Inhibitors; Etoposide; Exodeoxyribonucleases; Herpesvirus 1, Human; Humans; Piperazines; Plasmids; Replication Origin; Simian virus 40; Topoisomerase II Inhibitors; Transcription, Genetic; Viral Proteins; Virus Replication

1996
ICRF-193 modifies etoposide-induced apoptosis in thymocytes.
    Acta medica Okayama, 1995, Volume: 49, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cells, Cultured; Diketopiperazines; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Male; Mice; Microscopy, Fluorescence; Piperazines; Thymus Gland; Topoisomerase II Inhibitors

1995
Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors.
    The Journal of biological chemistry, 1996, Oct-18, Volume: 271, Issue:42

    Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Cinnamates; Crithidia fasciculata; Diketopiperazines; DNA; Enzyme Inhibitors; Etoposide; Indoles; Maleimides; Piperazines; Protein Kinase Inhibitors; Staurosporine; Topoisomerase II Inhibitors

1996
DNA topoisomerase II inhibitors enhance random integration of transfected vectors into human chromosomes.
    Somatic cell and molecular genetics, 1996, Volume: 22, Issue:4

    Topics: Amsacrine; Cell Line; Chromosomes, Human; Diketopiperazines; DNA Damage; Enzyme Inhibitors; Etoposide; Genetic Vectors; HeLa Cells; Humans; Kinetics; Piperazines; Plasmids; Recombination, Genetic; Topoisomerase II Inhibitors; Transfection

1996
E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis.
    Molecular and cellular biology, 1997, Volume: 17, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Survival; Diketopiperazines; DNA Damage; DNA-Binding Proteins; Doxorubicin; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Etoposide; Fluorouracil; Gamma Rays; Gene Expression; Humans; Piperazines; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma-Binding Protein 1; Topoisomerase II Inhibitors; Transcription Factor DP1; Transcription Factors; Tumor Suppressor Protein p53

1997
Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action.
    Journal of cell science, 1997, Volume: 110 ( Pt 3)

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Diketopiperazines; DNA Damage; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Etoposide; Humans; Immediate-Early Proteins; Monocytes; NF-kappa B; Piperazines; Protein Kinase C; Topoisomerase II Inhibitors; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured

1997
Effects of ICRF-193, a catalytic inhibitor of DNA topoisomerase II, on sister chromatid exchange.
    Anti-cancer drugs, 1997, Volume: 8, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Diketopiperazines; Enzyme Inhibitors; Etoposide; HeLa Cells; Humans; Methylnitronitrosoguanidine; Mutagens; Piperazines; Recombination, Genetic; Sister Chromatid Exchange; Topoisomerase II Inhibitors

1997
Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site.
    Molecular pharmacology, 1997, Volume: 52, Issue:5

    Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Diketopiperazines; DNA; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Etoposide; Indoles; Isoindoles; Piperazines; Razoxane; Topoisomerase II Inhibitors

1997
Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
    Cancer research, 1998, Apr-01, Volume: 58, Issue:7

    Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Base Sequence; Blotting, Western; CHO Cells; Cricetinae; Diketopiperazines; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Neoplasm; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Isoenzymes; Molecular Sequence Data; Mutation; Piperazines; Razoxane; Saccharomyces cerevisiae; Topoisomerase II Inhibitors

1998
Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha.
    Molecular pharmacology, 2000, Volume: 58, Issue:3

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; Catalysis; Diketopiperazines; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance; Enzyme Inhibitors; Etoposide; Humans; Isoenzymes; Molecular Sequence Data; Multienzyme Complexes; Mutation; Piperazines; Protein Conformation; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Topoisomerase II Inhibitors

2000
N-terminal and core-domain random mutations in human topoisomerase II alpha conferring bisdioxopiperazine resistance.
    FEBS letters, 2000, Sep-01, Volume: 480, Issue:2-3

    Topics: Adenosine Triphosphate; Amsacrine; Antigens, Neoplasm; Diketopiperazines; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance; Enzyme Inhibitors; Etoposide; Humans; Isoenzymes; Mutagenesis; Nucleic Acid Synthesis Inhibitors; Piperazines; Razoxane; Topoisomerase II Inhibitors

2000
Involvement of DNA topoisomerase IIbeta in neuronal differentiation.
    The Journal of biological chemistry, 2001, Feb-23, Volume: 276, Issue:8

    Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Nucleus; Cerebellar Cortex; Diketopiperazines; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Gene Expression Regulation; Isoenzymes; Male; Nerve Tissue Proteins; Neurons; Piperazines; Rats; Rats, Wistar; RNA, Messenger; Topoisomerase II Inhibitors

2001
Characterization of the biological and biochemical activities of F 11782 and the bisdioxopiperazines, ICRF-187 and ICRF-193, two types of topoisomerase II catalytic inhibitors with distinctive mechanisms of action.
    Anti-cancer drugs, 2000, Volume: 11, Issue:10

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Diketopiperazines; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Etoposide; Female; Humans; Leukemia P388; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Naphthalenes; Neoplasm Transplantation; Piperazines; Pyrans; Razoxane; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2000
Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.
    Biochemical pharmacology, 1999, May-15, Volume: 57, Issue:10

    Topics: Actins; Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Cell Division; Diketopiperazines; Etoposide; Humans; Molecular Sequence Data; Neoplasm Proteins; Piperazines; Sequence Homology, Amino Acid; Thymosin; Tumor Cells, Cultured; Zinostatin

1999
Decreased topoisomerase IIalpha expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells.
    Cancer letters, 2001, May-10, Volume: 166, Issue:1

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Cell Line; Colony-Forming Units Assay; Diketopiperazines; DNA Topoisomerases, Type II; DNA-Binding Proteins; Down-Regulation; Drug Resistance; Embryo, Mammalian; Enzyme Inhibitors; Etoposide; Gene Targeting; Heterozygote; Isoenzymes; Mice; Piperazines; RNA, Messenger; Stem Cells; Topoisomerase II Inhibitors

2001
DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates.
    Nature, 2001, Sep-27, Volume: 413, Issue:6854

    Topics: Animals; Antigens, Neoplasm; Cattle; Chromatin; Diketopiperazines; DNA Topoisomerases, Type II; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; HeLa Cells; Holoenzymes; Humans; Isoenzymes; Models, Genetic; Piperazines; RNA Polymerase II; Templates, Genetic; Topoisomerase II Inhibitors; Transcription Factors; Transcription, Genetic

2001
Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage.
    The Journal of biological chemistry, 2003, Sep-19, Volume: 278, Issue:38

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Line; Chickens; Diketopiperazines; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Etoposide; Genetic Vectors; Heterozygote; Models, Biological; Models, Genetic; Mutation; Piperazines; Recombination, Genetic; Transfection; Transgenes

2003
Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.
    Biochemical and biophysical research communications, 2004, Jun-11, Volume: 318, Issue:4

    Topics: Animals; Cell Line; Chickens; Diketopiperazines; DNA Damage; DNA Ligase ATP; DNA Ligases; DNA Repair; DNA Topoisomerases, Type II; Enzyme Inhibitors; Etoposide; Humans; Phenotype; Piperazines; Protein Serine-Threonine Kinases; Recombination, Genetic; Topoisomerase II Inhibitors

2004
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.
    Molecular cell, 2004, Sep-24, Volume: 15, Issue:6

    Topics: Cell Line, Tumor; Diketopiperazines; DNA; DNA Damage; Enzyme Inhibitors; Etoposide; HeLa Cells; Humans; Metaphase; Mitosis; Nocodazole; Nucleic Acid Synthesis Inhibitors; Piperazines; Topoisomerase II Inhibitors

2004
Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.
    DNA and cell biology, 2005, Volume: 24, Issue:6

    Topics: Animals; Cell Line, Tumor; Cell Survival; Chickens; Diketopiperazines; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Mutation; Piperazines; Rad52 DNA Repair and Recombination Protein; Recombination, Genetic; Topoisomerase II Inhibitors

2005
Decatenation checkpoint deficiency in stem and progenitor cells.
    Cancer cell, 2005, Volume: 8, Issue:6

    Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Chromosome Aberrations; Diketopiperazines; Etoposide; Genes, cdc; Hematopoietic Stem Cells; Humans; Mice; Neurons; Piperazines; Stem Cells; Time Factors

2005
Dangerous entanglements.
    Trends in molecular medicine, 2006, Volume: 12, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Transformation, Neoplastic; Chromosome Aberrations; Diketopiperazines; DNA Topoisomerases, Type II; Enzyme Inhibitors; Etoposide; G2 Phase; Genomic Instability; Humans; Piperazines; Regenerative Medicine; Stem Cell Transplantation; Stem Cells; Topoisomerase II Inhibitors

2006
A three-dimensional quantitative structure-activity relationship study of the inhibition of the ATPase activity and the strand passing catalytic activity of topoisomerase IIalpha by substituted purine analogs.
    Molecular pharmacology, 2006, Volume: 70, Issue:5

    Topics: Adenosine Triphosphatases; Antigens, Neoplasm; Catalysis; Cell Line; Diketopiperazines; DNA; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type II; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; HCT116 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Models, Molecular; Mutant Proteins; Piperazines; Purines; Quantitative Structure-Activity Relationship; Razoxane; Static Electricity; Topoisomerase II Inhibitors

2006
The requirement of Artemis in double-strand break repair depends on the type of DNA damage.
    DNA and cell biology, 2008, Volume: 27, Issue:1

    Topics: Blotting, Southern; Blotting, Western; Cells, Cultured; Colony-Forming Units Assay; Diketopiperazines; DNA Breaks, Double-Stranded; DNA Primers; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Radiation; Endonucleases; Enzyme Inhibitors; Etoposide; Flow Cytometry; Humans; Nuclear Proteins; Piperazines; Precursor Cells, B-Lymphoid; Radiation Tolerance; Radiation, Ionizing; Recombination, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Topoisomerase II Inhibitors

2008
DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.
    Biology of reproduction, 2013, Volume: 89, Issue:5

    Topics: Animals; Cells, Cultured; Chromosome Segregation; Chromosomes, Mammalian; Diketopiperazines; DNA Topoisomerases, Type II; Etoposide; Female; In Vitro Oocyte Maturation Techniques; Male; Meiosis; Mice; Mice, Inbred ICR; Oocytes; Oogenesis; Piperazines; Topoisomerase II Inhibitors

2013
Selective killing of G2 decatenation checkpoint defective colon cancer cells by catalytic topoisomerase II inhibitor.
    Biochimica et biophysica acta, 2015, Volume: 1853, Issue:5

    Topics: Biocatalysis; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Survival; Chromosomes, Human; Colonic Neoplasms; Diketopiperazines; Etoposide; G2 Phase; HEK293 Cells; Humans; Mitosis; Mitotic Index; Piperazines; Topoisomerase II Inhibitors; Tumor Stem Cell Assay

2015
Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection.
    Cell death & disease, 2020, 03-19, Volume: 11, Issue:3

    Topics: Adult; Aged; Apoptosis; CD4-Positive T-Lymphocytes; Chronic Disease; Diketopiperazines; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Female; Humans; Male; Middle Aged; Phosphoric Diester Hydrolases; Piperazines; Poly (ADP-Ribose) Polymerase-1; Telomerase; Telomere; Telomeric Repeat Binding Protein 2; Topoisomerase II Inhibitors; Virus Diseases; Young Adult

2020
Quantification of single-strand DNA lesions caused by the topoisomerase II poison etoposide using single DNA molecule imaging.
    Biochemical and biophysical research communications, 2022, 02-26, Volume: 594

    Topics: Antineoplastic Agents, Phytogenic; Diketopiperazines; DNA; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA, Single-Stranded; Dose-Response Relationship, Drug; Etoposide; Humans; Leukocytes, Mononuclear; Microscopy, Fluorescence; Single Molecule Imaging; Topoisomerase II Inhibitors

2022