Compounds > icrf 193
Page last updated: 2024-09-03

icrf 193 and camptothecin

icrf 193 has been researched along with camptothecin in 7 studies

Compound Research Comparison

Studies
(icrf 193)		Trials
(icrf 193)		Recent Studies (post-2010)
(icrf 193)		Studies
(camptothecin)		Trials
(camptothecin)		Recent Studies (post-2010) (camptothecin)
15503013,0022,2295,391

Protein Interaction Comparison

ProteinTaxonomyicrf 193 (IC50)camptothecin (IC50)
Histone deacetylase 3Homo sapiens (human)0.05
Multidrug resistance-associated protein 4Homo sapiens (human)7.4
DNA topoisomerase 1Homo sapiens (human)1.9799
Somatostatin receptor type 1Homo sapiens (human)0.0022
Somatostatin receptor type 2Homo sapiens (human)0.0022
Somatostatin receptor type 4Homo sapiens (human)0.0022
Somatostatin receptor type 3Homo sapiens (human)0.0022
Somatostatin receptor type 5Homo sapiens (human)0.0022
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.97
Histone deacetylase 4Homo sapiens (human)0.05
Histone deacetylase 1Homo sapiens (human)0.05
Histone deacetylase 7Homo sapiens (human)0.05
Histone deacetylase 2Homo sapiens (human)0.05
Polyamine deacetylase HDAC10Homo sapiens (human)0.05
Histone deacetylase 11 Homo sapiens (human)0.05
Histone deacetylase 8Homo sapiens (human)0.05
Histone deacetylase 6Homo sapiens (human)0.05
Histone deacetylase 9Homo sapiens (human)0.05
Histone deacetylase 5Homo sapiens (human)0.05

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's2 (28.57)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andoh, T; Ishida, R; Ishimi, Y1
Furue, H1
Andoh, T; Aratani, Y; Koyama, H1
Beere, HM; Chresta, CM; Hickman, JA1
Ishida, R; Nishida, K; Seto, M1
Ayusawa, D; Endoh, M; Fuji, M; Hossain, MN; Miki, K1
Takeda, S; Takenaka, K; Wang, X1

Reviews

1 review(s) available for icrf 193 and camptothecin

ArticleYear
[Topoisomerase inhibitors developing in Japan].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Benzopyrans; Camptothecin; Diketopiperazines; Glycosides; Humans; Irinotecan; Neoplasms; Phenazines; Piperazines; Razoxane; Topotecan

1993

Other Studies

6 other study(ies) available for icrf 193 and camptothecin

ArticleYear
Effect of ICRF-193, a novel DNA topoisomerase II inhibitor, on simian virus 40 DNA and chromosome replication in vitro.
    Molecular and cellular biology, 1992, Volume: 12, Issue:9

    Topics: Camptothecin; Cell Line; Chromosomes; Diketopiperazines; DNA Replication; DNA, Viral; Electrophoresis, Gel, Two-Dimensional; Etoposide; HeLa Cells; Humans; Neutralization Tests; Piperazines; Simian virus 40; Topoisomerase II Inhibitors

1992
Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells.
    Mutation research, 1996, Feb-15, Volume: 362, Issue:2

    Topics: Adenine Phosphoribosyltransferase; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; Diketopiperazines; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Mutagenesis; Mutagenicity Tests; Nucleic Acid Heteroduplexes; Piperazines; Recombination, Genetic; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transfection

1996
Selective inhibition of topoisomerase II by ICRF-193 does not support a role for topoisomerase II activity in the fragmentation of chromatin during apoptosis of human leukemia cells.
    Molecular pharmacology, 1996, Volume: 49, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Diketopiperazines; DNA Damage; Enzyme Inhibitors; Etoposide; Formamides; HL-60 Cells; Humans; Piperazines; Topoisomerase II Inhibitors

1996
Different susceptibilities of postmitotic checkpoint-proficient and -deficient Balb / 3T3 cells to ICRF-193, a catalytic inhibitor of DNA topoisomerase II.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:2

    Topics: 3T3 Cells; Animals; Camptothecin; Cell Survival; Chromosome Segregation; Diketopiperazines; DNA; Enzyme Inhibitors; Flow Cytometry; G1 Phase; Irinotecan; Mice; Mitosis; Piperazines; S Phase; Topoisomerase II Inhibitors

2001
Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses.
    Molecular and cellular biochemistry, 2007, Volume: 296, Issue:1-2

    Topics: Antimetabolites; Antineoplastic Agents; Bromodeoxyuridine; Camptothecin; Diketopiperazines; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Herbicides; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Hydrogen Peroxide; Oxidants; Paraquat; Piperazines; RNA, Small Interfering

2007
PTIP promotes DNA double-strand break repair through homologous recombination.
    Genes to cells : devoted to molecular & cellular mechanisms, 2010, Volume: 15, Issue:3

    Topics: Animals; B-Lymphocytes; Camptothecin; Carrier Proteins; Chickens; Diketopiperazines; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Gene Knockdown Techniques; Genomic Instability; HeLa Cells; Homologous Recombination; Humans; Molecular Sequence Data; Nuclear Proteins; Piperazines; Topoisomerase Inhibitors

2010