iclaprim has been researched along with trimethoprim in 9 studies
| Studies (iclaprim) | Trials (iclaprim) | Recent Studies (post-2010) (iclaprim) | Studies (trimethoprim) | Trials (trimethoprim) | Recent Studies (post-2010) (trimethoprim) |
|---|---|---|---|---|---|
| 45 | 7 | 16 | 6,989 | 845 | 894 |
| Protein | Taxonomy | iclaprim (IC50) | trimethoprim (IC50) |
|---|---|---|---|
| Chain A, Dihydrofolate reductase | Bacillus anthracis | 77200 | |
| Chain A, dihydrofolate reductase (DHFR) | Bacillus anthracis | 77200 | |
| Dihydrofolate reductase | Mycobacterium avium | 0.2588 | |
| Dihydrofolate reductase | Homo sapiens (human) | 1.8206 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.3493 | |
| Dihydrofolate reductase type 1 | Escherichia coli | 0.25 | |
| Dihydrofolate reductase | Neisseria gonorrhoeae | 0.45 | |
| Thymidylate synthase | Homo sapiens (human) | 3.405 | |
| Dihydrofolate reductase | Staphylococcus aureus | 0.0875 | |
| Thymidylate synthase | Escherichia coli K-12 | 3.405 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.6064 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.01 | |
| Dihydrofolate reductase type 1 from Tn4003 | Staphylococcus aureus | 0.023 | |
| Dipeptidyl peptidase 4 | Rattus norvegicus (Norway rat) | 2.7 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.7061 | |
| Dihydrofolate reductase | Candida albicans | 0.1361 | |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | 2.7 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.45 | |
| Metabotropic glutamate receptor 5 | Rattus norvegicus (Norway rat) | 2.73 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 2.8 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 3.2206 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium berghei ANKA | 0.12 | |
| Dihydrofolate reductase | Streptococcus pneumoniae TIGR4 | 0.0297 | |
| Dihydrofolate reductase | Lactococcus lactis subsp. lactis Il1403 | 0.45 | |
| Dihydrofolate reductase | Bacillus anthracis | 4.77 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 1.244 | |
| Dihydrofolate reductase | Pneumocystis jirovecii | 0.092 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hawser, S; Islam, K; Schneider, P | 1 |
| Fritsche, TR; Jones, RN; Sader, HS | 1 |
| Barrow, EW; Barrow, WW; Berlin, KD; Bourne, CR; Bourne, PC; Bunce, RA | 1 |
| Brown-Driver, V; Chen, Z; Creighton, C; Cunningham, M; Finn, J; G C, K; Hilgers, M; Kohnen, L; Kwan, B; Lam, T; Li, X; Nelson, K; Shaw, KJ; Stidham, M; Trzoss, M; Zhang, J | 1 |
| Brown-Driver, V; Cunningham, ML; Finn, J; Hilgers, MT; Hough, G; Kwan, BP; Lam, T; Nelson, KJ; Ong, V; Shaw, KJ; Trzoss, M | 1 |
| Bandera, M; Dale, GE; Haldimann, A; Laue, H; Lociuro, S; Mukhija, S; Oefner, C; Parisi, S; Schulz, H; Weiss, L | 1 |
| Dale, GE; Lociuro, S; Oefner, C; Parisi, S; Schulz, H | 1 |
| Huang, DB | 1 |
| Bryant, AE; Gomi, S; Huang, DB; Katahira, E; Stevens, DL | 1 |
9 other study(ies) available for iclaprim and trimethoprim
| Article | Year |
|---|---|
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria.
Topics: Animals; Drug Resistance, Bacterial; Folic Acid Antagonists; Lung; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Pyrimidines; Sepsis; Staphylococcus aureus; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim Resistance; Vancomycin | 2003 |
Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates.
Topics: Anti-Bacterial Agents; Enterococcus faecalis; Europe; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Hospitalization; Humans; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrimidines; Staphylococcus aureus; Streptococcus; United States | 2009 |
Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
Topics: Anti-Bacterial Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Microbial Sensitivity Tests; Protein Structure, Secondary; Protein Structure, Tertiary; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase | 2010 |
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Quinazolines; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2011 |
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Drug Resistance, Bacterial; Folic Acid Antagonists; Humans; Mice; Microbial Sensitivity Tests; Models, Molecular; Quinazolines; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2014 |
Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.
Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrimidines; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2009 |
Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Isomerism; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Multienzyme Complexes; Mutant Proteins; NADP; Protein Structure, Tertiary; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2009 |
Extracellular and intracellular activity of iclaprim against Listeria monocytogenes.
Topics: Anti-Bacterial Agents; Colony Count, Microbial; Folic Acid Antagonists; Listeria monocytogenes; Microbial Sensitivity Tests; Microbial Viability; Pyrimidines; Trimethoprim | 2019 |
The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Toxins; Biological Assay; Exotoxins; Folic Acid Antagonists; Methicillin-Resistant Staphylococcus aureus; Pyrimidines; Staphylococcus aureus; Trimethoprim; Vancomycin; Virulence Factors | 2019 |