ici d8731 has been researched along with losartan in 6 studies
| Studies (ici d8731) | Trials (ici d8731) | Recent Studies (post-2010) (ici d8731) | Studies (losartan) | Trials (losartan) | Recent Studies (post-2010) (losartan) |
|---|---|---|---|---|---|
| 15 | 0 | 0 | 7,231 | 1,245 | 2,118 |
| Protein | Taxonomy | ici d8731 (IC50) | losartan (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 9.01 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2.882 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.019 | |
| Atrial natriuretic peptide receptor 3 | Homo sapiens (human) | 0.0018 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.019 | |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0247 | |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0234 | |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | 0.0032 | |
| Type-1 angiotensin II receptor | Homo sapiens (human) | 0.047 | |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | 0.025 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0118 | |
| Type-2 angiotensin II receptor | Homo sapiens (human) | 0.019 | |
| Platelet glycoprotein VI | Homo sapiens (human) | 4 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.1481 | |
| Type-1 angiotensin II receptor | Cavia porcellus (domestic guinea pig) | 0.018 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.2884 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allott, CP; Bradbury, RH; Dennis, M; Girdwood, JA; Kenny, PW; Major, JS; Oldham, AA; Ratcliffe, AH; Rivett, JE; Roberts, DA | 1 |
| Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR | 1 |
| Giridhar, R; Murumkar, P; Naik, P; Yadav, MR | 1 |
| Auch-Schwelk, W; Duske, E; Fleck, E; Hess, B; Hildebrandt, AG; Klein, U; Regitz-Zagrosek, V; Steffen, C | 1 |
| Bauer, JH; Reams, GP | 1 |
| Masek, BB; Matthew, JB; Merchant, A | 1 |
3 review(s) available for ici d8731 and losartan
| Article | Year |
|---|---|
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship | 1996 |
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan | 2010 |
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs.
Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan | 1995 |
3 other study(ies) available for ici d8731 and losartan
| Article | Year |
|---|---|
New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cell Membrane; Female; Guinea Pigs; Hypertension, Renal; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Quinolines; Rats; Structure-Activity Relationship | 1993 |
Tissue- and subtype-specific modulation of angiotensin II receptors by chronic treatment with cyclosporin A, angiotensin-converting enzyme inhibitors and AT1 antagonists.
Topics: Administration, Oral; Adrenal Cortex; Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cyclosporine; Down-Regulation; Drug Interactions; Imidazoles; Kidney; Lisinopril; Liver; Losartan; Male; Pyridines; Quinolines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Up-Regulation | 1995 |
Molecular shape comparison of angiotensin II receptor antagonists.
Topics: Angiotensin Receptor Antagonists; Biphenyl Compounds; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Electrochemistry; Hydrogen Bonding; Imidazoles; Losartan; Models, Molecular; Molecular Conformation; Molecular Structure; Quinolines; Software; Tetrazoles | 1993 |