ici d2138 has been researched along with leukotriene b4 in 5 studies
| Studies (ici d2138) | Trials (ici d2138) | Recent Studies (post-2010) (ici d2138) | Studies (leukotriene b4) | Trials (leukotriene b4) | Recent Studies (post-2010) (leukotriene b4) |
|---|---|---|---|---|---|
| 23 | 2 | 0 | 5,886 | 232 | 717 |
| Protein | Taxonomy | ici d2138 (IC50) | leukotriene b4 (IC50) |
|---|---|---|---|
| Leukotriene B4 receptor 1 | Homo sapiens (human) | 0.0019 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bird, TG; Bruneau, P; Crawley, GC; Dowell, RI; Edwards, PN; Foster, SJ; Giroaeau, JM; McMillan, RM; Walker, ER; Waterson, D | 1 |
| Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER | 1 |
| Arm, JP; Bell, GS; Hawksworth, RJ; Lee, TH; MacMillan, R; Nasser, SM; Spruce, KE; Williams, AJ | 1 |
| Briggs, MT; Crawley, GC; Dowell, RI; Edwards, PN; Hamilton, PM; Kingston, JF; Oldham, K; Waterson, D; Whalley, DP | 1 |
| Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL | 1 |
1 trial(s) available for ici d2138 and leukotriene b4
| Article | Year |
|---|---|
Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses.
Topics: Adult; Asthma; Bronchial Provocation Tests; Double-Blind Method; Forced Expiratory Volume; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; In Vitro Techniques; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Spirometry | 1994 |
4 other study(ies) available for ici d2138 and leukotriene b4
| Article | Year |
|---|---|
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
Topics: Administration, Oral; Animals; Calcimycin; Drug Interactions; Eicosanoids; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Naphthalenes; Peritoneal Cavity; Pyrans; Quinolones; Rats; Structure-Activity Relationship; Thiazoles | 1992 |
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2 | 1992 |
4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.
Topics: Animals; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Pyrans; Quinolones; Stereoisomerism; Structure-Activity Relationship | 1993 |
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation | 2003 |