Page last updated: 2024-09-03

ici d2138 and leukotriene b4

ici d2138 has been researched along with leukotriene b4 in 5 studies

Compound Research Comparison

Studies
(ici d2138)
Trials
(ici d2138)
Recent Studies (post-2010)
(ici d2138)
Studies
(leukotriene b4)
Trials
(leukotriene b4)
Recent Studies (post-2010) (leukotriene b4)
23205,886232717

Protein Interaction Comparison

ProteinTaxonomyici d2138 (IC50)leukotriene b4 (IC50)
Leukotriene B4 receptor 1Homo sapiens (human)0.0019

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bird, TG; Bruneau, P; Crawley, GC; Dowell, RI; Edwards, PN; Foster, SJ; Giroaeau, JM; McMillan, RM; Walker, ER; Waterson, D1
Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER1
Arm, JP; Bell, GS; Hawksworth, RJ; Lee, TH; MacMillan, R; Nasser, SM; Spruce, KE; Williams, AJ1
Briggs, MT; Crawley, GC; Dowell, RI; Edwards, PN; Hamilton, PM; Kingston, JF; Oldham, K; Waterson, D; Whalley, DP1
Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL1

Trials

1 trial(s) available for ici d2138 and leukotriene b4

ArticleYear
Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses.
    Thorax, 1994, Volume: 49, Issue:8

    Topics: Adult; Asthma; Bronchial Provocation Tests; Double-Blind Method; Forced Expiratory Volume; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; In Vitro Techniques; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Spirometry

1994

Other Studies

4 other study(ies) available for ici d2138 and leukotriene b4

ArticleYear
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
    Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14

    Topics: Administration, Oral; Animals; Calcimycin; Drug Interactions; Eicosanoids; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Naphthalenes; Peritoneal Cavity; Pyrans; Quinolones; Rats; Structure-Activity Relationship; Thiazoles

1992
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2

1992
4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.
    Journal of medicinal chemistry, 1993, Jan-22, Volume: 36, Issue:2

    Topics: Animals; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Pyrans; Quinolones; Stereoisomerism; Structure-Activity Relationship

1993
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
    British journal of pharmacology, 2003, Volume: 139, Issue:7

    Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation

2003