ici d2138 and hydroxyurea
ici d2138 has been researched along with hydroxyurea in 7 studies
Compound Research Comparison
| Studies (ici d2138) | Trials (ici d2138) | Recent Studies (post-2010) (ici d2138) | Studies (hydroxyurea) | Trials (hydroxyurea) | Recent Studies (post-2010) (hydroxyurea) |
|---|---|---|---|---|---|
| 23 | 2 | 0 | 8,969 | 741 | 2,156 |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER | 1 |
| Carpenter, TG; Cuthbert, NJ; Fitzgerald, MF; Francis, HP; Gardiner, PJ; Mohrs, K; Müller-Peddinghaus, R; Newton, BB; Patel, UP; Thompson, AM | 1 |
| Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF | 1 |
| Currie, JL; Isakson, PC; Kim, S; Rao, T; Shaffer, AF; Smith, WG; Thompson, JM | 1 |
| Payne, AN; Price, RC; Yeadon, M | 1 |
| Andresen, CJ; Eggler, JF; Smith, WB; Turner, CR; Watson, JW | 1 |
| Amacher, DE; Beierschmitt, WP; Griffiths, RJ; McNeish, JD; Nagahisa, A; Nakane, M | 1 |
Other Studies
7 other study(ies) available for ici d2138 and hydroxyurea
| Article | Year |
|---|---|
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2 | 1992 |
Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.
Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Benzoquinones; Bronchoconstriction; Carrier Proteins; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Injections, Intravenous; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Ovalbumin; Pyrans; Quinolines; Quinolones; Trachea | 1994 |
Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley | 1993 |
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
Topics: Animals; Antigens; Blood Vessels; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Guinea Pigs; Humans; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Rats; Skin | 1995 |
Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138.
Topics: Acetylcholine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Glycoconjugates; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Hydroxylamines; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Methylurea Compounds; Pyrans; Quinolones; Spectrometry, Fluorescence; Trachea | 1995 |
The effect of 5-lipoxygenase inhibition on Ascaris antigen (Ag)-induced responses in atopic monkeys.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Helminth; Ascaris suum; Bronchoalveolar Lavage Fluid; Hydroxyurea; Inflammation; Leukocyte Count; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Neutrophils; Pyrans; Quinolones | 1996 |
Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hydroxyurea; Lipoxygenase Inhibitors; Liver; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Microsomes, Liver; NADH Dehydrogenase; Organ Size; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley | 2001 |