Page last updated: 2024-09-03

ici d2138 and carbostyril

ici d2138 has been researched along with carbostyril in 16 studies

Compound Research Comparison

Studies
(ici d2138)
Trials
(ici d2138)
Recent Studies (post-2010)
(ici d2138)
Studies
(carbostyril)
Trials
(carbostyril)
Recent Studies (post-2010) (carbostyril)
232012,8551,3235,611

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (81.25)18.2507
2000's3 (18.75)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bird, TG; Bruneau, P; Crawley, GC; Dowell, RI; Edwards, PN; Foster, SJ; Giroaeau, JM; McMillan, RM; Walker, ER; Waterson, D1
Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER1
Buckner, CK; Dea, DM; DeHaas, CJ; Krell, RD; Kusner, EJ; Marks, RL1
Carpenter, TG; Cuthbert, NJ; Fitzgerald, MF; Francis, HP; Gardiner, PJ; Mohrs, K; Müller-Peddinghaus, R; Newton, BB; Patel, UP; Thompson, AM1
Arm, JP; Bell, GS; Hawksworth, RJ; Lee, TH; MacMillan, R; Nasser, SM; Spruce, KE; Williams, AJ1
Arm, JP; Bell, GS; Foster, S; Lee, TH; MacMillan, R; Nasser, SM; Spruce, KE; Williams, AJ1
Bruneau, P; Foster, SJ; Lambert-van der Brempt, C; Lamorlette, MA1
Briggs, MT; Crawley, GC; Dowell, RI; Edwards, PN; Hamilton, PM; Kingston, JF; Oldham, K; Waterson, D; Whalley, DP1
Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF1
Currie, JL; Isakson, PC; Kim, S; Rao, T; Shaffer, AF; Smith, WG; Thompson, JM1
Payne, AN; Price, RC; Yeadon, M1
Andresen, CJ; Eggler, JF; Smith, WB; Turner, CR; Watson, JW1
McAlexander, MA; Myers, AC; Undem, BJ1
Amacher, DE; Beierschmitt, WP; Griffiths, RJ; McNeish, JD; Nagahisa, A; Nakane, M1
Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL1
Chen, K; Deng, Y; Jiang, H; Liu, H; Luo, X; Qiu, S; Ye, D; Zheng, M1

Trials

2 trial(s) available for ici d2138 and carbostyril

ArticleYear
Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses.
    Thorax, 1994, Volume: 49, Issue:8

    Topics: Adult; Asthma; Bronchial Provocation Tests; Double-Blind Method; Forced Expiratory Volume; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; In Vitro Techniques; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Spirometry

1994
Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma.
    Thorax, 1994, Volume: 49, Issue:8

    Topics: Adult; Aspirin; Asthma; Bronchial Provocation Tests; Calcimycin; Double-Blind Method; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Pyrans; Quinolones

1994

Other Studies

14 other study(ies) available for ici d2138 and carbostyril

ArticleYear
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
    Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14

    Topics: Administration, Oral; Animals; Calcimycin; Drug Interactions; Eicosanoids; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Naphthalenes; Peritoneal Cavity; Pyrans; Quinolones; Rats; Structure-Activity Relationship; Thiazoles

1992
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2

1992
The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses.
    European journal of pharmacology, 1994, May-23, Volume: 257, Issue:3

    Topics: Airway Resistance; Animals; Antigens; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine Release; Indoles; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Phospholipases A; Phospholipases A2; Pyrans; Quinolones; Thromboxane B2; Thromboxane-A Synthase

1994
Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.
    European journal of pharmacology, 1994, Jun-02, Volume: 258, Issue:1-2

    Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Benzoquinones; Bronchoconstriction; Carrier Proteins; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Injections, Intravenous; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Ovalbumin; Pyrans; Quinolines; Quinolones; Trachea

1994
Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.
    Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Binding Sites; Computer Simulation; Humans; Lipoxygenase Inhibitors; Macrophages; Mice; Models, Molecular; Molecular Conformation; Naphthalenes; Pyrans; Quinolones; Serum Albumin; Structure-Activity Relationship; Thiazoles

1994
4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.
    Journal of medicinal chemistry, 1993, Jan-22, Volume: 36, Issue:2

    Topics: Animals; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Pyrans; Quinolones; Stereoisomerism; Structure-Activity Relationship

1993
Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.
    Life sciences, 1993, Volume: 53, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley

1993
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: Animals; Antigens; Blood Vessels; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Guinea Pigs; Humans; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Rats; Skin

1995
Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138.
    Pulmonary pharmacology, 1995, Volume: 8, Issue:1

    Topics: Acetylcholine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Glycoconjugates; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Hydroxylamines; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Methylurea Compounds; Pyrans; Quinolones; Spectrometry, Fluorescence; Trachea

1995
The effect of 5-lipoxygenase inhibition on Ascaris antigen (Ag)-induced responses in atopic monkeys.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Helminth; Ascaris suum; Bronchoalveolar Lavage Fluid; Hydroxyurea; Inflammation; Leukocyte Count; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Neutrophils; Pyrans; Quinolones

1996
Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2

    Topics: Animals; Arachidonate 5-Lipoxygenase; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leukotriene C4; Lipoxygenase Inhibitors; Male; Muscle Contraction; Pyrans; Quinolones; Tachykinins; Trachea; Vagus Nerve

1998
Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 63, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hydroxyurea; Lipoxygenase Inhibitors; Liver; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Microsomes, Liver; NADH Dehydrogenase; Organ Size; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley

2001
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
    British journal of pharmacology, 2003, Volume: 139, Issue:7

    Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation

2003
Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.
    Bioorganic & medicinal chemistry letters, 2007, May-01, Volume: 17, Issue:9

    Topics: Animals; Arachidonate 5-Lipoxygenase; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Indoles; Inhibitory Concentration 50; Leukocytes; Lipoxygenase Inhibitors; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Pyrans; Quinolones; Rats

2007