ici d2138 has been researched along with carbostyril in 16 studies
| Studies (ici d2138) | Trials (ici d2138) | Recent Studies (post-2010) (ici d2138) | Studies (carbostyril) | Trials (carbostyril) | Recent Studies (post-2010) (carbostyril) |
|---|---|---|---|---|---|
| 23 | 2 | 0 | 12,855 | 1,323 | 5,611 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (81.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bird, TG; Bruneau, P; Crawley, GC; Dowell, RI; Edwards, PN; Foster, SJ; Giroaeau, JM; McMillan, RM; Walker, ER; Waterson, D | 1 |
| Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER | 1 |
| Buckner, CK; Dea, DM; DeHaas, CJ; Krell, RD; Kusner, EJ; Marks, RL | 1 |
| Carpenter, TG; Cuthbert, NJ; Fitzgerald, MF; Francis, HP; Gardiner, PJ; Mohrs, K; Müller-Peddinghaus, R; Newton, BB; Patel, UP; Thompson, AM | 1 |
| Arm, JP; Bell, GS; Hawksworth, RJ; Lee, TH; MacMillan, R; Nasser, SM; Spruce, KE; Williams, AJ | 1 |
| Arm, JP; Bell, GS; Foster, S; Lee, TH; MacMillan, R; Nasser, SM; Spruce, KE; Williams, AJ | 1 |
| Bruneau, P; Foster, SJ; Lambert-van der Brempt, C; Lamorlette, MA | 1 |
| Briggs, MT; Crawley, GC; Dowell, RI; Edwards, PN; Hamilton, PM; Kingston, JF; Oldham, K; Waterson, D; Whalley, DP | 1 |
| Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF | 1 |
| Currie, JL; Isakson, PC; Kim, S; Rao, T; Shaffer, AF; Smith, WG; Thompson, JM | 1 |
| Payne, AN; Price, RC; Yeadon, M | 1 |
| Andresen, CJ; Eggler, JF; Smith, WB; Turner, CR; Watson, JW | 1 |
| McAlexander, MA; Myers, AC; Undem, BJ | 1 |
| Amacher, DE; Beierschmitt, WP; Griffiths, RJ; McNeish, JD; Nagahisa, A; Nakane, M | 1 |
| Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL | 1 |
| Chen, K; Deng, Y; Jiang, H; Liu, H; Luo, X; Qiu, S; Ye, D; Zheng, M | 1 |
2 trial(s) available for ici d2138 and carbostyril
| Article | Year |
|---|---|
Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses.
Topics: Adult; Asthma; Bronchial Provocation Tests; Double-Blind Method; Forced Expiratory Volume; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; In Vitro Techniques; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Spirometry | 1994 |
Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma.
Topics: Adult; Aspirin; Asthma; Bronchial Provocation Tests; Calcimycin; Double-Blind Method; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Pyrans; Quinolones | 1994 |
14 other study(ies) available for ici d2138 and carbostyril
| Article | Year |
|---|---|
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
Topics: Administration, Oral; Animals; Calcimycin; Drug Interactions; Eicosanoids; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Naphthalenes; Peritoneal Cavity; Pyrans; Quinolones; Rats; Structure-Activity Relationship; Thiazoles | 1992 |
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2 | 1992 |
The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses.
Topics: Airway Resistance; Animals; Antigens; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine Release; Indoles; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Phospholipases A; Phospholipases A2; Pyrans; Quinolones; Thromboxane B2; Thromboxane-A Synthase | 1994 |
Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.
Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Benzoquinones; Bronchoconstriction; Carrier Proteins; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Injections, Intravenous; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Ovalbumin; Pyrans; Quinolines; Quinolones; Trachea | 1994 |
Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.
Topics: Animals; Arachidonate 5-Lipoxygenase; Binding Sites; Computer Simulation; Humans; Lipoxygenase Inhibitors; Macrophages; Mice; Models, Molecular; Molecular Conformation; Naphthalenes; Pyrans; Quinolones; Serum Albumin; Structure-Activity Relationship; Thiazoles | 1994 |
4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.
Topics: Animals; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Pyrans; Quinolones; Stereoisomerism; Structure-Activity Relationship | 1993 |
Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley | 1993 |
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
Topics: Animals; Antigens; Blood Vessels; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Guinea Pigs; Humans; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Rats; Skin | 1995 |
Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138.
Topics: Acetylcholine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Glycoconjugates; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Hydroxylamines; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Methylurea Compounds; Pyrans; Quinolones; Spectrometry, Fluorescence; Trachea | 1995 |
The effect of 5-lipoxygenase inhibition on Ascaris antigen (Ag)-induced responses in atopic monkeys.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Helminth; Ascaris suum; Bronchoalveolar Lavage Fluid; Hydroxyurea; Inflammation; Leukocyte Count; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Neutrophils; Pyrans; Quinolones | 1996 |
Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway.
Topics: Animals; Arachidonate 5-Lipoxygenase; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leukotriene C4; Lipoxygenase Inhibitors; Male; Muscle Contraction; Pyrans; Quinolones; Tachykinins; Trachea; Vagus Nerve | 1998 |
Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hydroxyurea; Lipoxygenase Inhibitors; Liver; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Microsomes, Liver; NADH Dehydrogenase; Organ Size; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley | 2001 |
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation | 2003 |
Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.
Topics: Animals; Arachidonate 5-Lipoxygenase; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Indoles; Inhibitory Concentration 50; Leukocytes; Lipoxygenase Inhibitors; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Pyrans; Quinolones; Rats | 2007 |