Compounds > ici 211965
Page last updated: 2024-09-05

ici 211965 and zileuton

ici 211965 has been researched along with zileuton in 5 studies

Compound Research Comparison

Studies
(ici 211965)		Trials
(ici 211965)		Recent Studies (post-2010)
(ici 211965)		Studies
(zileuton)		Trials
(zileuton)		Recent Studies (post-2010) (zileuton)
80055164193

Protein Interaction Comparison

ProteinTaxonomyici 211965 (IC50)zileuton (IC50)
Prostaglandin E synthaseHomo sapiens (human)0.6
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)1.4782
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)0.9656
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)0.4
Arachidonate 5-lipoxygenase-activating proteinHomo sapiens (human)0.58
Bifunctional epoxide hydrolase 2Homo sapiens (human)0.591
Polyunsaturated fatty acid 5-lipoxygenaseMus musculus (house mouse)0.19
Leukotriene B4 receptor 1Homo sapiens (human)0.42
Cysteinyl leukotriene receptor 2Homo sapiens (human)0.42
Cysteinyl leukotriene receptor 1Homo sapiens (human)0.42

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bird, TG; Bruneau, P; Crawley, GC; Dowell, RI; Edwards, PN; Foster, SJ; Giroaeau, JM; McMillan, RM; Walker, ER; Waterson, D1
Bruneau, P; Crawley, GC; Edwards, MP; Foster, SJ; Girodeau, JM; Kingston, JF; McMillan, RM1
Brideau, C; Chan, CC; Dubé, D; Ducharme, Y; Falgueyret, JP; Gillard, JW; Guay, J; Hutchinson, JH; McFarlane, CS; Riendeau, D1
Falgueyret, JP; Hutchinson, JH; Riendeau, D1
Rainsford, KD; Smith, F; Ying, C1

Other Studies

5 other study(ies) available for ici 211965 and zileuton

ArticleYear
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
    Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14

    Topics: Administration, Oral; Animals; Calcimycin; Drug Interactions; Eicosanoids; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Naphthalenes; Peritoneal Cavity; Pyrans; Quinolones; Rats; Structure-Activity Relationship; Thiazoles

1992
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:7

    Topics: Administration, Oral; Animals; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Guinea Pigs; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Naphthalenes; Rats; Structure-Activity Relationship; Thiazoles; Thromboxane B2

1991
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.
    Journal of medicinal chemistry, 1994, Feb-18, Volume: 37, Issue:4

    Topics: Animals; Benzofurans; Humans; Lactones; Lipoxygenase; Lipoxygenase Inhibitors; Male; Naphthalenes; Neutrophils; Pyrans; Rats; Rats, Sprague-Dawley; Saimiri; Structure-Activity Relationship; Thiazoles

1994
Criteria for the identification of non-redox inhibitors of 5-lipoxygenase.
    Biochemical pharmacology, 1993, Feb-24, Volume: 45, Issue:4

    Topics: Arachidonate 5-Lipoxygenase; Benzeneacetamides; Benzofurans; Enzyme Inhibitors; Humans; Hydroxamic Acids; Hydroxyurea; Indoles; Leukotrienes; Lipid Peroxides; Lipoxygenase Inhibitors; Naphthalenes; Oxidation-Reduction; Thiazoles

1993
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:1

    Topics: Animals; Benzofurans; Enzyme-Linked Immunosorbent Assay; Hip Joint; Humans; Hydroxyurea; Indoles; Interleukin-1; Knee Joint; Lipoxygenase Inhibitors; Naphthalenes; Organ Culture Techniques; Oxindoles; Pyrazoles; Quinolines; Structure-Activity Relationship; Swine; Synovial Membrane; Tarsus, Animal; Thiazoles; Thiophenes

1996