Compounds > ici 204,219
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ici 204,219 and leukotriene d4

ici 204,219 has been researched along with leukotriene d4 in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (56.67)18.2507
2000's9 (30.00)29.6817
2010's2 (6.67)24.3611
2020's2 (6.67)2.80

Authors

AuthorsStudies
Baronissi, G; Biagioli, M; Cassiano, C; Catalanotti, B; Conflitti, P; De Luca, P; Fiorillo, B; Fiorucci, S; Limongelli, V; Marchianò, S; Rapacciuolo, P; Roselli, R; Sepe, V; Zampella, A1
Casale, TB; Donnelly, AL; Glass, M; Minkwitz, MC1
Abram, T; Brink, C; Cuthbert, N; Gardiner, P; Gorenne, I; Labat, C; Morcillo, E; Norman, P; Ortiz, JL; Tudhop, S1
Buckner, CK; Dehaas, CJ; Krell, RD; Kusner, EJ; Lengel, DJ; Williams, JC1
Chan, CC; Ecclestone, P; Metters, KM; Nicholson, DW; Pon, DJ; Rodger, IW1
Björck, T; Dahlén, B; Dahlén, SE; Zetterström, O1
Glass, M; Minkwitz, MC; Smith, LJ1
Glass, M; Minkwitz, MC; Nathan, RA1
Douglas, I; Herrnreiter, A; Leff, AR; Mayer, D; Muñoz, NM; Zhu, X1
Anderson, GP; Ball, HA; Beck, A; Bittiger, H; Bray, MA; Felner, A; Gentsch, C; Gerspacher, M; Giese, K; Hauser, K; Kraetz, J; Niederhauser, U; Subramanian, N; Vassout, A; von Sprecher, A1
Khawaja, AM; Liu, YC; Rogers, DF1
Hanby, LA; Lavins, BJ; Simonson, SG; Smith, LJ1
Ciocca, V; Hay, DW; Leonard, TB; Luttmann, MA; Panettieri, RA; Tan, EM1
Lane, SJ1
Antognoli, GW; Chambers, RJ; Cheng, JB; Marfat, A; Pillar, JS; Shirley, JT; Watson, JW1
Bäck, M; Brink, C; Dahlén, S; Gascard, J; Mazmanian, G; Norel, X; Walch, L1
Bäck, M; Sakata, K1
Andersen, L; Bouchelouche, K; Bouchelouche, P; Horn, T; Nordling, J1
Wooltorton, E1
Balduino, A; Barreiro, EJ; Diaz, BL; e Silva, PM; Fraga, CA; Lima, LM; Martins, MA; Miranda, AL; Neves, JS; Siqueira, Rde A1
Baatjes, A; Gauvreau, GM; MacGlashan, DW; Plitt, JR1
Hiyama, Y; Ishimura, M; Kataoka, S; Maeda, T; Suda, M1
Joos, G; Pauwels, R; Schelfhout, V; Van De Velde, V1
Becker, EM; Ergüden, J; Geerts, A; Härter, M; Hütter, J; Kast, R; Kolkhof, P; Tinel, H; Wunder, F1
Denton, JS; Figueroa, EE; Kramer, M; Strange, K1
Al-Azzam, N; Elsalem, L1
Belloni, PA; Bolla, M; Capra, V; Folco, GC; Mezzetti, M; Nicosia, S; Rovati, GE1
Abramovitz, M; Austin, CP; Bai, C; Caskey, CT; Chateauneuf, A; Connolly, BM; Coulombe, N; Evans, JF; Figueroa, DJ; Ford-Hutchinson, AW; Greig, GM; Hooks, SB; Hosfield, E; Im, DS; Kargman, S; Liu, Q; Lynch, KR; Metters, KM; O'Neill, GP; Sawyer, N; Stocco, R; Williams, DL; Zeng, Z1
Ames, RS; Bergsma, DJ; Buckley, PT; Chambers, J; Dytko, GM; Ellis, C; Elshourbagy, N; Foley, JJ; Halsey, W; Hay, DW; Herrity, NC; Jenkins, O; Muccitelli, RM; Muir, AI; Murdock, PR; Nuthulaganti, P; Sarau, HM; Sathe, G; Schmidt, DB; Wilson, S1
Abramovitz, M; Austin, CP; Bellefeuille, JN; Cheng, R; Clements, MK; Coulombe, N; Evans, JF; Figueroa, DJ; George, SR; Heise, CE; Im, DS; Liu, Q; Liu, Y; Lynch, KR; Ma, L; Metters, KM; Nguyen, T; O'Dowd, BF; O'Neill, GP; Sawyer, N; Stocco, R; Williams, DL; Zeng, Z1

Reviews

2 review(s) available for ici 204,219 and leukotriene d4

ArticleYear
Leukotriene antagonism in asthma and rhinitis.
    Respiratory medicine, 1998, Volume: 92, Issue:6

    Topics: Acetates; Asthma; Bronchi; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Membrane Proteins; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Rhinitis; Sinusitis; Sulfides; Sulfonamides; Tosyl Compounds

1998
Leukotriene D
    Life sciences, 2020, Nov-01, Volume: 260

    Topics: Acetates; Airway Remodeling; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Cyclopropanes; Cysteine; Gene Expression; Humans; Hypersensitivity; Indoles; Inflammation Mediators; Leukotriene Antagonists; Leukotriene D4; Leukotrienes; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Sulfides; Sulfonamides; Tosyl Compounds

2020

Trials

6 trial(s) available for ici 204,219 and leukotriene d4

ArticleYear
The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis.
    American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:6

    Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indoles; Leukotriene D4; Male; Phenylcarbamates; Rhinitis, Allergic, Seasonal; Sulfonamides; Time Factors; Tosyl Compounds

1995
The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics.
    The European respiratory journal, 1994, Volume: 7, Issue:2

    Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Double-Blind Method; Forced Expiratory Volume; Humans; Indoles; Leukotriene D4; Male; Phenylcarbamates; Reproducibility of Results; Skin Tests; Sulfonamides; Tosyl Compounds

1994
Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219.
    Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Humans; Indoles; Leukotriene D4; Male; Middle Aged; Phenylcarbamates; Sulfonamides; Tosyl Compounds

1993
Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma.
    Chest, 1994, Volume: 105, Issue:2

    Topics: Administration, Inhalation; Adult; Allergens; Antigens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Indoles; Leukotriene D4; Male; Phenylcarbamates; Pollen; Reproducibility of Results; Sulfonamides; Tosyl Compounds; Vital Capacity

1994
A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 81, Issue:1

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Anti-Asthmatic Agents; Asthma; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Female; Humans; Indoles; Leukotriene D4; Male; Phenylcarbamates; Sulfonamides; Tosyl Compounds

1998
The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:2

    Topics: Adult; Arachidonate 5-Lipoxygenase; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Glutathione Transferase; Humans; Indoles; Leukotriene Antagonists; Leukotriene D4; Neurokinin A; Phenylcarbamates; Polymorphism, Genetic; Sulfonamides; Tosyl Compounds

2008

Other Studies

22 other study(ies) available for ici 204,219 and leukotriene d4

ArticleYear
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
    Journal of medicinal chemistry, 2021, 11-25, Volume: 64, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Humans; Leukotriene D4; Macrophages; Mice; Molecular Docking Simulation; Protein Binding; RAW 264.7 Cells; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Structure-Activity Relationship

2021
Antagonism of leukotriene responses in human airways by BAY x7195.
    European journal of pharmacology, 1995, Mar-06, Volume: 275, Issue:2

    Topics: Antibodies, Anti-Idiotypic; Bronchodilator Agents; Female; Humans; Hydroxy Acids; Immunoglobulin E; Indoles; Leukotriene C4; Leukotriene D4; Lung Neoplasms; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Pulmonary Veins; Sulfonamides; Tosyl Compounds

1995
Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate).
    Annals of the New York Academy of Sciences, 1994, Nov-15, Volume: 744

    Topics: Animals; Capillary Permeability; Cell Movement; Eosinophils; Guinea Pigs; Indoles; Leukocyte Count; Leukotriene D4; Lung; Male; Phenylcarbamates; Sulfonamides; Tosyl Compounds

1994
Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3

    Topics: Calcium; Cytosol; Humans; Indoles; Leukemia, Myeloid; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Phenylcarbamates; Propionates; Quinolines; Receptors, Leukotriene; Sulfonamides; Tosyl Compounds; Tumor Cells, Cultured

1994
Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism.
    American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:4

    Topics: Animals; Cell Movement; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene B4; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Phenylcarbamates; Receptors, Leukotriene; Receptors, Leukotriene B4; Sulfonamides; Tosyl Compounds; Trachea

1997
CGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type.
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Acetates; Animals; Anti-Asthmatic Agents; Bronchoconstriction; Cyclopropanes; Guinea Pigs; Indoles; Leukotriene Antagonists; Leukotriene D4; Lung; Molecular Structure; Muscle, Smooth; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds

1997
Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro.
    British journal of pharmacology, 1998, Volume: 124, Issue:3

    Topics: Adenosine Triphosphate; Animals; Anti-Asthmatic Agents; Binding, Competitive; Chromones; Cysteine; Guinea Pigs; Hypersensitivity; In Vitro Techniques; Indoles; Leukotriene Antagonists; Leukotriene D4; Male; Membrane Proteins; Mucus; Ovalbumin; Passive Cutaneous Anaphylaxis; Phenylcarbamates; Receptors, Leukotriene; Sulfates; Sulfonamides; Sulfur Radioisotopes; Tosyl Compounds; Trachea

1998
Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists.
    American journal of respiratory cell and molecular biology, 1998, Volume: 19, Issue:3

    Topics: Asthma; Carbachol; Cells, Cultured; Chromones; Dicarboxylic Acids; DNA Replication; Epidermal Growth Factor; Extracellular Matrix Proteins; Gene Expression Regulation; Humans; Indoles; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phenylcarbamates; Receptors, Leukotriene; RNA, Messenger; Sulfonamides; Tosyl Compounds; Trachea; Transforming Growth Factor beta

1998
Development of new chromanol antagonists of leukotriene D4.
    Bioorganic & medicinal chemistry letters, 1998, Jul-21, Volume: 8, Issue:14

    Topics: Animals; Chromans; Chromones; Guinea Pigs; Humans; Indoles; Leukotriene Antagonists; Leukotriene D4; Phenylcarbamates; Protein Binding; Sulfonamides; Tosyl Compounds

1998
Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes.
    European journal of pharmacology, 2000, Aug-11, Volume: 401, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Male; Membrane Proteins; Phenylcarbamates; Pulmonary Artery; Receptors, Leukotriene; SRS-A; Sulfonamides; Swine; Thromboxane A2; Tosyl Compounds; Vasoconstriction

2000
Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma.
    European journal of pharmacology, 2002, Feb-01, Volume: 436, Issue:1-2

    Topics: Animals; Bronchodilator Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Lung; Male; Membrane Proteins; Muscle Contraction; Nitric Oxide Synthase; Nitroarginine; Phenylcarbamates; Propionates; Quinolines; Receptors, Leukotriene; Sulfonamides; Tosyl Compounds

2002
The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle.
    The Journal of urology, 2003, Volume: 170, Issue:2 Pt 1

    Topics: Acetates; Calcium; Cells, Cultured; Cyclopropanes; Cysteine; Cytosol; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Indoles; Leukotriene Antagonists; Leukotriene D4; Leukotrienes; Membrane Proteins; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Sarcoplasmic Reticulum; Sulfides; Sulfonamides; Tosyl Compounds; Urinary Bladder

2003
Asthma drug zafirlukast (Accolate): serious hepatic events.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2004, May-25, Volume: 170, Issue:11

    Topics: Anti-Asthmatic Agents; Asthma; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Indoles; Leukotriene D4; Phenylcarbamates; Sulfonamides; Tosyl Compounds

2004
Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats.
    European journal of pharmacology, 2005, Mar-28, Volume: 511, Issue:2-3

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Calcium; CD4-Positive T-Lymphocytes; Cell Movement; Chemokine CCL11; Chemokines, CC; CHO Cells; Cricetinae; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eosinophils; Female; Indoles; Inflammation; Isoindoles; Leukotriene D4; Leukotrienes; Male; Membrane Proteins; Phenylcarbamates; Pleura; Pleurisy; Rats; Rats, Wistar; Receptors, Leukotriene; Sulfonamides; Tetrazoles; Tosyl Compounds; Transfection

2005
Expression of functional cysteinyl leukotriene receptors by human basophils.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:1

    Topics: Basophils; Blotting, Western; Calcium; Cell Survival; Chemotaxis; fas Receptor; Flow Cytometry; Gene Expression; Histamine; Humans; Indoles; Interleukin-13; Interleukin-4; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Phenylcarbamates; Receptors, Leukotriene; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tosyl Compounds

2005
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
    Allergology international : official journal of the Japanese Society of Allergology, 2006, Volume: 55, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan

2006
Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor.
    British journal of pharmacology, 2010, Volume: 160, Issue:2

    Topics: Animals; Calcium; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Humans; Indoles; Inhibitory Concentration 50; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Male; Myocardial Contraction; Phenylcarbamates; Phthalic Acids; Protein Binding; Receptors, Leukotriene; Sulfonamides; Tosyl Compounds

2010
CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
    American journal of physiology. Cell physiology, 2019, 10-01, Volume: 317, Issue:4

    Topics: Anions; Cell Size; Chromones; Epithelial Cells; HEK293 Cells; Humans; Indoles; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Phenylcarbamates; Receptors, Leukotriene; Signal Transduction; Sulfonamides; Tosyl Compounds

2019
Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro.
    British journal of pharmacology, 1998, Volume: 123, Issue:3

    Topics: Antigens; Benzopyrans; Binding, Competitive; Bronchi; Humans; In Vitro Techniques; Leukotriene D4; Lung; Muscle Contraction

1998
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
    Nature, 1999, Jun-24, Volume: 399, Issue:6738

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Chromosome Mapping; Cloning, Molecular; COS Cells; Humans; Leukotriene Antagonists; Leukotriene D4; Lung; Macrophages, Alveolar; Membrane Proteins; Molecular Sequence Data; Muscle, Smooth; Receptors, Leukotriene; Tissue Distribution; Transfection; X Chromosome; Xenopus laevis

1999
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
    Molecular pharmacology, 1999, Volume: 56, Issue:3

    Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Biological Transport; Calcium; Cells, Cultured; Cloning, Molecular; Humans; Leukotriene D4; Membrane Proteins; Molecular Sequence Data; Pertussis Toxin; Receptors, Leukotriene; Signal Transduction; Virulence Factors, Bordetella

1999
Characterization of the human cysteinyl leukotriene 2 receptor.
    The Journal of biological chemistry, 2000, Sep-29, Volume: 275, Issue:39

    Topics: Adrenal Medulla; Cloning, Molecular; Cysteine; Humans; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Lung; Membrane Proteins; Models, Molecular; Myocardium; Receptors, Leukotriene; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; SRS-A; Tissue Distribution

2000