ici-199441 has been researched along with bremazocine* in 1 studies
1 other study(ies) available for ici-199441 and bremazocine
| Article | Year |
|---|---|
A novel series of potent and selective agonists at the opioid kappa-receptor.
Three novel opioid agonists are described. These compounds were found to bind with high affinity and selectivity to the kappa-opioid receptor. Isolated tissue studies using the field-stimulated mouse vas deferens and guinea-pig ileum preparations confirmed the high agonist potency and naloxone-reversibility of these agents. All three compounds exhibited potent antinociceptive activity in the mouse abdominal constriction model. These compounds should prove useful as tools to investigate kappa-receptor function. Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Mice; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |