Page last updated: 2024-09-03

ici 153066 and ketoconazole

ici 153066 has been researched along with ketoconazole in 13 studies

Compound Research Comparison

Studies (ici 153066)	Trials (ici 153066)	Recent Studies (post-2010) (ici 153066)	Studies (ketoconazole)	Trials (ketoconazole)	Recent Studies (post-2010) (ketoconazole)
19	0	0	6,202	706	1,269

Protein Interaction Comparison

Protein	Taxonomy	ketoconazole (IC50)
Solute carrier family 22 member 1	Homo sapiens (human)	2.6
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Homo sapiens (human)	0.34
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Mus musculus (house mouse)	0.36
Bile salt export pump	Homo sapiens (human)	3.44
Steroid 17-alpha-hydroxylase/17,20 lyase	Homo sapiens (human)	1.5811
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	6.7
ATP-dependent translocase ABCB1	Homo sapiens (human)	4.6771
Cytochrome P450 3A4	Homo sapiens (human)	0.1969
Steroid 21-hydroxylase	Homo sapiens (human)	6.655
Cytochrome P450 2C8	Homo sapiens (human)	0.06
Aromatase	Homo sapiens (human)	1.4111
Steroid 17-alpha-hydroxylase/17,20 lyase	Rattus norvegicus (Norway rat)	2.0802
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	5.425
Cholesterol side-chain cleavage enzyme, mitochondrial	Rattus norvegicus (Norway rat)	3.32
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	1.067
Cytochrome P450 2A2	Rattus norvegicus (Norway rat)	0.456
Cytochrome P450 11B1, mitochondrial	Bos taurus (cattle)	0.38
Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)	0.162
Translocator protein	Rattus norvegicus (Norway rat)	3.76
Cytochrome P450 7A1	Rattus norvegicus (Norway rat)	1.2975
Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)	0.5179
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	3.8
Thromboxane-A synthase	Homo sapiens (human)	2.165
Gonadotropin-releasing hormone receptor	Rattus norvegicus (Norway rat)	2
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.531
Type-1 angiotensin II receptor	Oryctolagus cuniculus (rabbit)	0.0078
Cytochrome P450 4F2	Homo sapiens (human)	1.6
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	Homo sapiens (human)	0.4144
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	1.9036
Lanosterol 14-alpha demethylase	Homo sapiens (human)	0.19
Cytochrome P450 7A1	Mus musculus (house mouse)	1.2975
Lanosterol 14-alpha demethylase	Rattus norvegicus (Norway rat)	0.083

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (92.31)	18.7374
1990's	1 (7.69)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adams, DJ; Brown, SB; Dickinson, K; Evans, EG; Hitchcock, CA	1
Abbott, AB; Cockayne, A; Hayward, J; Odds, FC	1
Cauwenbergh, G	1
Abruzzo, GK; Bulmer, GS; Fromtling, RA	1
Meingassner, JG; Schaude, M	1
Beggs, WH; Hughes, CE	1
Brummer, E; Hoyos, GL; Lefler, E; McEwen, JG; Restrepo, A; Stevens, DA	1
Brummer, E; Lefler, E; Perlman, AM; Stevens, DA	1
Polak, A	1
Drutz, DJ; Graybill, JR; Kaster, SR	1
Barrett-Bee, KJ; Ryley, JF; Wilson, RG	1
Espinel-Ingroff, A; Kerkering, TM; Shadomy, S	1
Gerding, DN; Harris, C; Hughes, CE; Moody, JA; Peterson, LR	1

Other Studies

13 other study(ies) available for ici 153066 and ketoconazole

Article	Year
Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. The Biochemical journal, 1990, Mar-01, Volume: 266, Issue:2 Topics: Antifungal Agents; Azoles; Candida albicans; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ferric Compounds; Ketoconazole; Mevalonic Acid; Oxidoreductases; Spectrum Analysis; Sterol 14-Demethylase; Triazoles	1990
Effects of imidazole- and triazole-derivative antifungal compounds on the growth and morphological development of Candida albicans hyphae. Journal of general microbiology, 1985, Volume: 131, Issue:10 Topics: Amphotericin B; Antifungal Agents; Candida albicans; Clotrimazole; Flucytosine; Imidazoles; Itraconazole; Ketoconazole; Miconazole; Triazoles	1985
New and prospective developments in antifungal drugs. Acta dermato-venereologica. Supplementum, 1986, Volume: 121 Topics: Administration, Oral; Administration, Topical; Allylamine; Antifungal Agents; Clotrimazole; Dermatomycoses; Drug Compounding; Humans; Imidazoles; Itraconazole; Ketoconazole; Miconazole; Naphthalenes; Terbinafine; Triazoles	1986
Cryptococcus neoformans: comparisons of in vitro antifungal susceptibilities of serotypes AD and BC. Mycopathologia, 1986, Volume: 94, Issue:1 Topics: Amphotericin B; Antifungal Agents; Cryptococcus; Cryptococcus neoformans; Flucytosine; Itraconazole; Ketoconazole; Miconazole; Microbial Sensitivity Tests; Nystatin; Serotyping; Triazoles	1986
A diffusion chamber technique for testing of antifungal drugs against Sporothrix schenckii in vivo. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 1986, Volume: 24, Issue:4 Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Female; Itraconazole; Ketoconazole; Mice; Potassium Iodide; Sporothrix; Sporotrichosis; Triazoles	1986
Irrelevance of growth phase with respect to the Bay n 7133 and ICI 153,066 susceptibilities of Candida albicans. Diagnostic microbiology and infectious disease, 1986, Volume: 4, Issue:1 Topics: Anti-Bacterial Agents; Candida albicans; In Vitro Techniques; Ketoconazole; Miconazole; Microbial Sensitivity Tests; Triazoles	1986
Study of current and new drugs in a murine model of acute paracoccidioidomycosis. The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:1 Topics: Amphotericin B; Animals; Imidazoles; Ketoconazole; Lung; Male; Mice; Mice, Inbred BALB C; Paracoccidioides; Paracoccidioidomycosis; Spleen; Triazoles	1985
Activities of the modified polyene N-D-ornithyl amphotericin methyl ester and the azoles ICI 153066, Bay n 7133, and Bay l 9139 compared with those of amphotericin B and ketoconazole in the therapy of experimental blastomycosis. Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:3 Topics: Amphotericin B; Animals; Antifungal Agents; Blastomycosis; Imidazoles; Ketoconazole; Male; Mice; Mice, Inbred BALB C; Time Factors; Triazoles	1985
Antimycotic therapy of experimental infections caused by dematiaceous fungi. Sabouraudia, 1984, Volume: 22, Issue:4 Topics: Amphotericin B; Animals; Antifungal Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Flucytosine; Fluorouracil; Humans; Ketoconazole; Male; Mice; Mitosporic Fungi; Mycoses; Triazoles	1984
Comparative activities of Bay n7133, ICI 153,066, and ketoconazole in murine cryptococcosis. Antimicrobial agents and chemotherapy, 1983, Volume: 24, Issue:6 Topics: Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Female; Ketoconazole; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Triazoles	1983
Azole resistance in Candida albicans. Sabouraudia, 1984, Volume: 22, Issue:1 Topics: Amino Acids; Animals; Antifungal Agents; Candida albicans; Candidiasis, Chronic Mucocutaneous; Candidiasis, Vulvovaginal; Drug Resistance, Microbial; Ergosterol; Female; Ketoconazole; Mice; Rats; Triazoles	1984
In-vitro studies with four new antifungal agents: BAY n 7133, bifonazole (BAY h 4502), ICI 153,066 and Ro 14-4767/002. Sabouraudia, 1984, Volume: 22, Issue:1 Topics: Antifungal Agents; Arthrodermataceae; Blastomyces; Candida; Coccidioides; Cryptococcus neoformans; Drug Evaluation, Preclinical; Histoplasma; Imidazoles; Ketoconazole; Miconazole; Morpholines; Sporothrix; Triazoles	1984
In vitro activities of amphotericin B in combination with four antifungal agents and rifampin against Aspergillus spp. Antimicrobial agents and chemotherapy, 1984, Volume: 25, Issue:5 Topics: Amphotericin B; Antifungal Agents; Aspergillus; Flucytosine; Ketoconazole; Microbial Sensitivity Tests; Rifampin; Triazoles	1984