ici 106270 has been researched along with clonidine in 5 studies
| Studies (ici 106270) | Trials (ici 106270) | Recent Studies (post-2010) (ici 106270) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 6 | 0 | 0 | 13,692 | 2,044 | 1,394 |
| Protein | Taxonomy | ici 106270 (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kulkarni, SK; Kunchandy, J | 1 |
| Fernandez-Roman, M; Fuentes, JA; Naranjo, JR; Urdin, MC | 1 |
| Hynes, MD; Ruffolo, RR; Timmermans, PB; van Zwieten, PA; Yaden, EL | 1 |
| Clough, DP; Hatton, R; Pettinger, SJ | 1 |
| Clough, DP; Keddie, J; Pettinger, SJ | 1 |
5 other study(ies) available for ici 106270 and clonidine
| Article | Year |
|---|---|
Modulatory effect of alpha 2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice.
Topics: Animals; Anticonvulsants; Azepines; Benzodiazepinones; Brain; Clonidine; Convulsants; Guanfacine; Guanidines; Imidazoles; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, GABA-A; Seizures | 1987 |
Beta-endorphin: a common factor in the antihypertensive action of clonidine-type imidazolines in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; beta-Endorphin; Blood Pressure; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Endorphins; Hypertension; Imidazoles; Injections, Intraventricular; Male; Quinoxalines; Rats | 1985 |
Characterization of the alpha adrenoceptor-mediated effects and antihypertensive activity of ICI 106270: comparison with clonidine.
Topics: Animals; Antihypertensive Agents; Brain; Clonidine; Dose-Response Relationship, Drug; Guinea Pigs; Hypertension; Imidazoles; Male; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sleep | 1984 |
A new centrally acting antihypertensive (ICI 106270) which separates antihypertensive effects from sedation.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Female; Heart Rate; Hypertension, Renal; Imidazoles; Motor Activity; Pentobarbital; Rats; Sleep; Sympathetic Nervous System | 1981 |
The withdrawal of centrally acting antihypertensives in dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dogs; Heart Rate; Humans; Imidazoles; Male; Substance Withdrawal Syndrome; Time Factors | 1981 |