icaritin and thiazolyl-blue

icaritin has been researched along with thiazolyl-blue* in 2 studies

Other Studies

2 other study(ies) available for icaritin and thiazolyl-blue

Article	Year
Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study. PloS one, 2012, Volume: 7, Issue:8 We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogenic differentiation of MSCs. Unlike the findings of others on EF compounds, we showed that Icaritin was unable to promote proliferation, migration and tube like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. These results suggested that the exogenous phytomolecule Icaritin possessed the potential for enhancing bone formation via its osteopromotive but not an osteoinductive mechanism. Though some flavonoids were shown to regulate the coupling process of angiogenesis and osteogenesis during bone repair, our results suggested that Icaritin did not have direct effect on enhancing angiogenesis in vitro. Topics: Antineoplastic Agents, Phytogenic; Bone and Bones; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Endothelial Cells; Flavonoids; Humans; In Vitro Techniques; Neovascularization, Pathologic; Osteoblasts; Osteogenesis; Phenotype; Stem Cells; Tetrazolium Salts; Thiazoles	2012
Synthesis and antimultidrug resistance evaluation of icariin and its derivatives. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 A series of icariin derivatives were synthesized. Their multidrug resistance (MDR) reversal activities were evaluated by MTT assay and the results indicated that the derivatives were the potent modulators of MDR. It was showed that the derivatives significantly increased the intracellular accumulation of ADR in MCF-7/ADR cells compared with drug sensitive MCF-7 cells. The results of bi-directional assay and reverse transcription polymerase chain reaction (RT-PCR) assay showed that the derivatives had high inhibitory activity against P-gp efflux function and significantly down-regulated on the expression of P-gp. Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Humans; Inhibitory Concentration 50; Models, Chemical; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Time Factors	2009

Article

Year

Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study.

PloS one, 2012, Volume: 7, Issue:8

We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogenic differentiation of MSCs. Unlike the findings of others on EF compounds, we showed that Icaritin was unable to promote proliferation, migration and tube like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. These results suggested that the exogenous phytomolecule Icaritin possessed the potential for enhancing bone formation via its osteopromotive but not an osteoinductive mechanism. Though some flavonoids were shown to regulate the coupling process of angiogenesis and osteogenesis during bone repair, our results suggested that Icaritin did not have direct effect on enhancing angiogenesis in vitro.

Topics: Antineoplastic Agents, Phytogenic; Bone and Bones; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Endothelial Cells; Flavonoids; Humans; In Vitro Techniques; Neovascularization, Pathologic; Osteoblasts; Osteogenesis; Phenotype; Stem Cells; Tetrazolium Salts; Thiazoles

2012

Synthesis and antimultidrug resistance evaluation of icariin and its derivatives.

Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

A series of icariin derivatives were synthesized. Their multidrug resistance (MDR) reversal activities were evaluated by MTT assay and the results indicated that the derivatives were the potent modulators of MDR. It was showed that the derivatives significantly increased the intracellular accumulation of ADR in MCF-7/ADR cells compared with drug sensitive MCF-7 cells. The results of bi-directional assay and reverse transcription polymerase chain reaction (RT-PCR) assay showed that the derivatives had high inhibitory activity against P-gp efflux function and significantly down-regulated on the expression of P-gp.

Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Humans; Inhibitory Concentration 50; Models, Chemical; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Time Factors

2009