ic 261 has been researched along with phloroglucinol in 27 studies
*Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent. [MeSH]
*Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 11 (40.74) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Bergmeier, SC; DeMaggio, AJ; Egli, M; Hoekstra, MF; Kuret, J; Mashhoon, N; Tereshko, V | 1 |
| Behrend, L; Campbell, LE; Deppert, W; Knippschild, U; Meek, DW; Milne, DM; Stöter, M | 1 |
| Roth, MG; Yu, S | 1 |
| Cooper, CD; Lampe, PD | 1 |
| Kuret, J; Li, G; Yin, H | 1 |
| Chen, Y; Duan, Y; El-Hayek, YH; Li, L; Liao, M; Liu, B; Mielke, JG; Ning, K; Wan, Q | 1 |
| Kattapuram, T; Maki, JL; Stone, JR; Yang, S | 1 |
| Aslan, B; Bamberger, AM; Deppert, W; Frank, HG; Henne-Bruns, D; Kaufmann, P; Knippschild, U; Kurth, M; Löhler, J; Löning, T; Speidel, D; Stöter, M | 1 |
| Adams, J; Bialucha, CU; Dupre-Crochet, S; Ferber, EC; Figueroa, A; Fujita, Y; Hogan, C; Richardson, EC | 1 |
| Amoresano, A; Campanella, C; Cirulli, C; D'Angelo, A; Garzia, L; Iolascon, A; Knauer, SK; Stauber, RH; Steegborn, C; Zollo, M | 1 |
| Ammerpohl, O; Bohm, B; Brockschmidt, C; Eismann, T; Giamas, G; Henne-Bruns, D; Hillenbrand, A; Hirner, H; Huber, N; Kalthoff, H; Knippschild, U; Leithäuser, F; Radunsky, B; Trauzold, A | 1 |
| Brunner, M; Diernfellner, A; Heise, F; Lauinger, L; Neiss, A; Querfurth, C; Schafmeier, T; Tataroglu, O | 1 |
| Stockwell, BR; Yang, WS | 1 |
| Boehm, JS; Dunn, IF; Firestein, R; Gupta, P; Hahn, WC; Kim, SY; Lander, ES; Ramaswamy, S; Repich, K; Root, DE; Schinzel, AC; Silver, SJ; Wardwell, L; Wittner, B | 1 |
| Baumann, K; Höttecke, N; Liebeck, M; Schmidt, B; Schubenel, R; Steiner, H; Winkler, E | 1 |
| Cheong, JK; Lee, SH; Nguyen, TH; Tan, P; Virshup, DM; Voorhoeve, PM; Wang, H | 1 |
| Andrysík, Z; Kabátková, M; Kohoutek, J; Kozubík, A; Machala, M; Procházková, J; Simečková, P; Umannová, L; Vondráček, J | 1 |
| Barrios-Llerena, ME; Hindle, M; Le Bihan, T; Martin, SF; Millar, AJ; O'Neill, JS; van Ooijen, G | 1 |
| Aulner, N; Durieu, E; Leclercq, O; Meijer, L; Notredame, C; Pescher, P; Prina, E; Rachidi, N; Späth, GF; Taly, JF | 1 |
| Asada, T; Hagiwara, M; Kawamoto, D; Kii, I; Kurihara, T; Miyata, A; Sakurai, E; Tanabe, T; Toyomoto, M; Yoshimura, M | 1 |
| Banting, G; Henne-Bruns, D; Knippschild, U; Krüger, M; Stöter, M | 1 |
| Beilina, A; Chia, R; Cookson, MR; Haddock, S; Kaganovich, A; Kumaran, R; Li, Y; Mamais, A; Nalls, MA; Rudenko, IN | 1 |
| Bischof, J; Fischer-Posovszky, P; Henne-Bruns, D; Hillenbrand, A; Knippschild, U; Radermacher, P; Wabitsch, M; Wolf, AM; Xu, P | 1 |
| Guo, S; Kelly, DF; Liang, Y; Murphy, S; Pham, L; Pridham, KJ; Sheng, Z; Varghese, RT; Young, S | 1 |
| Fang, T; Guo, M; Huang, P; Li, D; Qi, F; Rao, Q; Sun, J; Xia, J; Yang, B; Yuan, F; Zhao, Z | 1 |
| Chang, H; Hu, Y; Jia, H; Li, J; Liu, M; Lu, M; Lu, S; Ren, F; Zhong, J; Zhou, M | 1 |
| Bu, F; Long, F; Tao, Y; Wang, G; Wang, T; Wang, Y; Wu, C; Xian, J; Zhang, Z | 1 |
1 review(s) available for ic 261 and phloroglucinol
| Article | Year |
|---|---|
Posttranslational regulation of Neurospora circadian clock by CK1a-dependent phosphorylation.
Topics: Casein Kinase I; Circadian Rhythm; CLOCK Proteins; DNA-Binding Proteins; Feedback, Physiological; Fungal Proteins; Genes, Fungal; Indoles; Isoenzymes; Models, Biological; Neurospora; Phloroglucinol; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Trans-Activators; Transcription Factors | 2007 |
26 other study(ies) available for ic 261 and phloroglucinol
| Article | Year |
|---|---|
Crystal structure of a conformation-selective casein kinase-1 inhibitor.
Topics: Casein Kinases; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydrogen Bonding; Indoles; Inhibitory Concentration 50; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Oxindoles; Peptide Library; Phloroglucinol; Phosphotransferases; Protein Binding; Protein Conformation; Protein Isoforms; Protein Kinase Inhibitors; Protein Structure, Tertiary; Schizosaccharomyces; Static Electricity | 2000 |
IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects.
Topics: Animals; Casein Kinases; Cell Cycle; Cell Survival; Cells, Cultured; Centrosome; Enzyme Inhibitors; Fibroblasts; Indoles; Mice; Mice, Inbred BALB C; Mitosis; Nocodazole; Phloroglucinol; Protein Kinase Inhibitors; Signal Transduction; Tumor Suppressor Protein p53 | 2000 |
Casein kinase I regulates membrane binding by ARF GAP1.
Topics: ADP-Ribosylation Factors; Animals; Casein Kinases; Cell Membrane; CHO Cells; COS Cells; Cricetinae; Golgi Apparatus; Green Fluorescent Proteins; GTPase-Activating Proteins; Hemagglutinins, Viral; Indoles; Isoenzymes; Luminescent Proteins; Membrane Glycoproteins; Phloroglucinol; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Transport; Recombinant Fusion Proteins; Time Factors; Viral Envelope Proteins | 2002 |
Casein kinase 1 regulates connexin-43 gap junction assembly.
Topics: Animals; Casein Kinases; Cell Membrane; Cells, Cultured; Connexin 43; Gap Junctions; Immunohistochemistry; Indoles; Isoenzymes; Isoquinolines; Kidney; Phloroglucinol; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rats; Recombinant Fusion Proteins | 2002 |
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Topics: Alzheimer Disease; Casein Kinases; Cell Line; Humans; Indoles; Microtubules; Phloroglucinol; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Substrate Specificity; tau Proteins | 2004 |
Circadian regulation of GABAA receptor function by CKI epsilon-CKI delta in the rat suprachiasmatic nuclei.
Topics: Analysis of Variance; Animals; Blotting, Western; Casein Kinases; Circadian Rhythm; Darkness; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; In Vitro Techniques; Indoles; Lighting; Male; Membrane Potentials; Patch-Clamp Techniques; Phloroglucinol; Precipitin Tests; Protein Kinases; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Suprachiasmatic Nucleus; Time Factors | 2004 |
Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.
Topics: Amino Acid Sequence; Animals; Casein Kinase Ialpha; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Endothelium, Vascular; Escherichia coli; Evolution, Molecular; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Hydrogen Peroxide; Immunoprecipitation; Indoles; Kinetics; Liver; Mice; Molecular Sequence Data; Phloroglucinol; Phosphorylation; Protein Binding; Protein Structure, Tertiary; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Spectrometry, Fluorescence | 2005 |
Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.
Topics: Apoptosis; Blotting, Western; Casein Kinase Idelta; Cell Line; Cell Line, Transformed; Cell Survival; Centrosome; Choriocarcinoma; Female; Flow Cytometry; Genes, p53; Glutathione Transferase; Green Fluorescent Proteins; Histocytochemistry; Humans; Hybrid Cells; Immunohistochemistry; Indoles; Microscopy, Fluorescence; Phloroglucinol; Placenta; Pregnancy; Protein Kinase Inhibitors; Recombinant Fusion Proteins; Sequence Analysis, DNA; Spindle Apparatus; Trophoblasts; Tumor Suppressor Protein p53 | 2005 |
Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts.
Topics: Amino Acid Sequence; Animals; beta Catenin; Cadherins; Casein Kinase I; Cell Adhesion; Cells, Cultured; Endocytosis; Humans; Indoles; Intercellular Junctions; Isoenzymes; Molecular Sequence Data; Phloroglucinol; Phosphorylation; RNA Interference; Sequence Alignment; Serine | 2007 |
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Caenorhabditis elegans; Carrier Proteins; Cell Communication; Cell Movement; Chlorocebus aethiops; COS Cells; Cyclin-Dependent Kinase Inhibitor Proteins; Drosophila melanogaster; Humans; Indoles; NM23 Nucleoside Diphosphate Kinases; Peptide Fragments; Phloroglucinol; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Phosphorylation; Xenopus laevis | 2008 |
Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Casein Kinase 1 epsilon; Casein Kinase Idelta; Cell Proliferation; Deoxycytidine; Drug Evaluation, Preclinical; fas Receptor; Gemcitabine; Humans; Indoles; Lymphatic Metastasis; Mice; Mice, SCID; Neoplasm Transplantation; Pancreatic Neoplasms; Phloroglucinol; Transplantation, Heterologous; Tumor Cells, Cultured | 2008 |
Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest.
Topics: Casein Kinase 1 epsilon; Cell Line, Tumor; Cell Survival; Humans; Indoles; Neoplasms; Nuclear Proteins; Period Circadian Proteins; Phloroglucinol; RNA Interference; Transcription Factors | 2008 |
CK1epsilon is required for breast cancers dependent on beta-catenin activity.
Topics: Animals; beta Catenin; Breast Neoplasms; Casein Kinase 1 epsilon; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Indoles; Mice; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; Phloroglucinol; RNA Interference; Signal Transduction | 2010 |
Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.
Topics: Amyloid Precursor Protein Secretases; Binding Sites; Casein Kinase I; Casein Kinase Idelta; Indoles; Phloroglucinol; Protease Inhibitors; Structure-Activity Relationship | 2010 |
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; beta Catenin; Casein Kinase 1 epsilon; Casein Kinase Idelta; Cell Cycle; Cell Line, Tumor; Dishevelled Proteins; Humans; Indoles; Neoplasms; Phloroglucinol; Phosphoproteins; Phosphorylation; Pyrazoles; Pyrimidines; RNA, Small Interfering; Spindle Apparatus; Wnt Proteins | 2011 |
Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication.
Topics: Animals; Benz(a)Anthracenes; Carcinogens; Cell Communication; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Connexin 43; Contact Inhibition; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Fluorenes; Gap Junctions; Gene Knockdown Techniques; Indoles; Ligands; Liver; Liver Neoplasms; Phloroglucinol; Phosphorylation; Polychlorinated Dibenzodioxins; Proteasome Endopeptidase Complex; Rats; Receptors, Aryl Hydrocarbon; RNA Interference; Signal Transduction; Time Factors; Transfection | 2013 |
Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga.
Topics: Alleles; Amino Acid Sequence; Animals; Casein Kinase I; Chlorophyta; Circadian Clocks; Computational Biology; Conserved Sequence; Cricetinae; Gene Expression; Gene Expression Regulation, Plant; Indoles; Mice; Molecular Sequence Data; Mutation; Phloroglucinol; Phosphoproteins; Phosphorylation; Photoperiod; Protein Kinase Inhibitors; Sequence Alignment; Sequence Homology, Amino Acid; Transcriptional Activation | 2013 |
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.
Topics: Animals; Benzamides; Casein Kinase I; Conserved Sequence; Cricetinae; Female; Imidazoles; Indoles; Isoquinolines; Leishmania donovani; Leishmaniasis, Visceral; Macrophages; Mice, Inbred C57BL; Phloroglucinol; Sequence Alignment; Trypanocidal Agents | 2014 |
Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.
Topics: Animals; Carrageenan; Casein Kinase I; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Humans; Hyperalgesia; Indoles; Inflammation; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Pain Threshold; Phloroglucinol; Protein Transport; Spinal Cord; Thiazoles | 2014 |
Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage.
Topics: Animals; Apoptosis; Casein Kinase I; Cell Cycle Checkpoints; Chlorocebus aethiops; Enzyme Inhibitors; Humans; Indoles; Interphase; Microtubules; Phloroglucinol; Rats; Tubulin Modulators | 2014 |
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Topics: Animals; Benzamides; Casein Kinase Ialpha; Cerebral Cortex; Corpus Striatum; Gene Expression Regulation; HEK293 Cells; Humans; Imidazoles; Indoles; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phloroglucinol; Phosphorylation; Primary Cell Culture; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rho Guanine Nucleotide Exchange Factors; RNA, Small Interfering; Signal Transduction; trans-Golgi Network | 2014 |
Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.
Topics: Adipocytes; Adiponectin; Adolescent; Adult; Aged; Casein Kinase I; Female; Gene Expression Regulation, Enzymologic; HEK293 Cells; Humans; Immunoprecipitation; Indoles; Isoenzymes; Male; Middle Aged; Obesity, Morbid; Omentum; Phloroglucinol; Phosphorylation; Protein Multimerization; Pyrazoles; Pyrimidines; Subcutaneous Fat; Young Adult | 2015 |
Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival.
Topics: Animals; beta Catenin; Casein Kinase I; Cell Line, Tumor; Cell Survival; Glioblastoma; Humans; Indoles; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Phloroglucinol; Pyrazoles; Pyrimidines; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
IC261 suppresses progression of hepatocellular carcinoma in a casein kinase 1 δ/ε independent manner.
Topics: Animals; Carcinoma, Hepatocellular; Casein Kinase 1 epsilon; Casein Kinase Idelta; Cell Line, Tumor; Cell Proliferation; Disease Progression; Humans; Indoles; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Phloroglucinol; Protein Kinase Inhibitors | 2020 |
IC261, a specific inhibitor of CK1δ/ε, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer.
Topics: Apoptosis; Blotting, Western; Casein Kinase 1 epsilon; Casein Kinase Idelta; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Glycolysis; HCT116 Cells; Humans; Immunohistochemistry; Indoles; Lactic Acid; Phloroglucinol; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2020 |
A Rationale for Drug Design Provided by Co-Crystal Structure of IC261 in Complex with Tubulin.
Topics: Animals; Binding Sites; Casein Kinase I; Colchicine; Crystallography, X-Ray; Drug Design; Indoles; Microtubules; Molecular Docking Simulation; Phloroglucinol; Protein Conformation; Structure-Activity Relationship; Swine; Tubulin; Tubulin Modulators | 2021 |