Page last updated: 2024-08-24

ibutilide and sotalol

ibutilide has been researched along with sotalol in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (38.46)18.2507
2000's14 (53.85)29.6817
2010's2 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G; Turcotte, UM1
Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G1
Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM1
Lee, EW; Lee, KS; Tsai, TD1
Brunden, MN; Buchanan, LV; Gibson, JK; Hsu, CY; LeMay, RJ; Walters, RR1
DiMarco, JP; Jung, F1
Bharucha, D; Kowey, PR; Marinchak, RA; Rials, SJ1
Golitsyn, SR; Harry, JD; Perry, KT; Ruda, MY; Stangl, K; Steinbeck, G; Touboul, P; Van Wijk, LV; Vos, MA; Wellens, HJ1
Podrid, PJ1
Sager, PT1
Dorian, P; Qi, X1
Bianconi, L; Castro, A; Santini, M1
Brendel, J; Busch, AE; Knobloch, K; Peukert, S; Rosenstein, B; Wirth, KJ1
DeBisschop, M; Lower, DL; Martin, LG; Yamreudeewong, W1
Khan, MH1
Bleich, M; Brendel, J; Busch, AE; Knobloch, K; Rosenstein, B; Wirth, KJ1
Borchard, R; Brandts, B; Dirkmann, D; Meine, M; Prull, MW; Trappe, HJ; Van Bracht, M; Wickenbrock, I1
Brendorp, B; Elming, H; Køber, L; Pedersen, OD; Pehrson, S; Torp-Petersen, C1
Allessie, M; Blaauw, Y; Duytschaever, M1
Scharf, C1
Kluger, J; Shah, SA; White, CM1

Reviews

11 review(s) available for ibutilide and sotalol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Antiarrhythmic drug therapy in the treatment of atrial fibrillation.
    Cardiology clinics, 1996, Volume: 14, Issue:4

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Clinical Trials as Topic; Electrophysiology; Flecainide; Humans; Ion Channels; Quinidine; Sotalol; Sulfonamides

1996
Pharmacologic and pharmacokinetic profile of class III antiarrhythmic drugs.
    The American journal of cardiology, 1997, Oct-23, Volume: 80, Issue:8A

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Humans; Phenethylamines; Sotalol; Sulfonamides

1997
New advances in class III antiarrhythmic drug therapy.
    Current opinion in cardiology, 2000, Volume: 15, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides

2000
Antiarrhythmic drugs and ventricular defibrillation energy requirements.
    Chinese medical journal, 1999, Volume: 112, Issue:12

    Topics: Animals; Anti-Arrhythmia Agents; Defibrillators, Implantable; Humans; Phenethylamines; Sotalol; Sulfonamides; Ventricular Fibrillation

1999
New antiarrhythmic drugs for the treatment of atrial fibrillation.
    Pacing and clinical electrophysiology : PACE, 2002, Volume: 25, Issue:2

    Topics: Aminobenzoates; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dronedarone; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides

2002
Potentially significant drug interactions of class III antiarrhythmic drugs.
    Drug safety, 2003, Volume: 26, Issue:6

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Drug Interactions; Humans; Phenethylamines; Sotalol; Sulfonamides

2003
Oral class III antiarrhythmics: what is new?
    Current opinion in cardiology, 2004, Volume: 19, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Dronedarone; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides; Tachycardia, Supraventricular; Tachycardia, Ventricular; Treatment Outcome

2004
A benefit-risk assessment of class III antiarrhythmic agents.
    Expert opinion on drug safety, 2004, Volume: 3, Issue:6

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Combined Modality Therapy; Defibrillators, Implantable; Dronedarone; Heart Conduction System; Humans; Hydantoins; Imidazolidines; Ion Transport; Life Tables; Membrane Potentials; Meta-Analysis as Topic; Phenethylamines; Piperazines; Risk Assessment; Sotalol; Sulfonamides; Survival Analysis; Torsades de Pointes; Treatment Outcome

2004
[Atrial flutter and fibrillation].
    Praxis, 2005, Nov-09, Volume: 94, Issue:45

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Calcium Channel Blockers; Catheter Ablation; Clinical Trials as Topic; Disopyramide; Electric Countershock; Electrocardiography; Emergencies; Flecainide; Heart Rate; Humans; Middle Aged; Pacemaker, Artificial; Propafenone; Quinidine; Recurrence; Sotalol; Sulfonamides; Treatment Outcome; Vasodilator Agents

2005
Monotherapy versus combination therapy with class III antiarrhythmic agents to attenuate transmural dispersion of repolarization: a potential risk factor for torsade de pointes.
    Pharmacotherapy, 2007, Volume: 27, Issue:9

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Conduction System; Humans; Sotalol; Sulfonamides; Torsades de Pointes

2007

Trials

1 trial(s) available for ibutilide and sotalol

ArticleYear
Superiority of ibutilide (a new class III agent) over DL-sotalol in converting atrial flutter and atrial fibrillation. The Ibutilide/Sotalol Comparator Study Group.
    Heart (British Cardiac Society), 1998, Volume: 79, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Double-Blind Method; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Prospective Studies; Sotalol; Sulfonamides; Time Factors

1998

Other Studies

14 other study(ies) available for ibutilide and sotalol

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
Effects of ibutilide on spontaneous and induced ventricular arrhythmias in 24-hour canine myocardial infarction: a comparative study with sotalol and encainide.
    Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Electrocardiography; Encainide; Hemodynamics; Myocardial Infarction; Sotalol; Sulfonamides

1992
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes

1993
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium

1995
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
    European journal of pharmacology, 1993, Mar-30, Volume: 234, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides

1993
Antiarrhythmic and electrophysiologic effects of intravenous ibutilide and sotalol in the canine sterile pericarditis model.
    Journal of cardiovascular electrophysiology, 1996, Volume: 7, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Cross-Over Studies; Dogs; Electrocardiography; Infusions, Intravenous; Male; Pericarditis; Sotalol; Sulfonamides; Tachycardia, Atrioventricular Nodal Reentry

1996
Redefining the role of antiarrhythmic drugs.
    The New England journal of medicine, 1999, Jun-17, Volume: 340, Issue:24

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Chemotherapy, Adjuvant; Defibrillators, Implantable; Electric Countershock; Humans; Premedication; Sotalol; Sulfonamides; Tachycardia

1999
Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide.
    Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Biphenyl Compounds; Cation Transport Proteins; Electrophysiology; Ether-A-Go-Go Potassium Channels; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Kv1.5 Potassium Channel; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sotalol; Sulfonamides; Swine; Ventricular Function

2002
Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:7

    Topics: Adrenergic beta-Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Atropine; Biphenyl Compounds; Chromans; Flecainide; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Propafenone; Propanolamines; Sotalol; Sulfonamides; Swine; Ventricular Function

2004
[Perspectives and limitations in the treatment of vagus-induced atrial fibrillation. Insights from cellular pharmacology].
    Medizinische Klinik (Munich, Germany : 1983), 2004, Jul-15, Volume: 99, Issue:7

    Topics: Adult; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cells, Cultured; Culture Media; Heart Atria; Humans; Membrane Potentials; Phenethylamines; Potassium Channel Blockers; Rats; Sotalol; Sulfonamides; Time Factors; Vagus Nerve

2004
Consequences of atrial electrical remodeling for the anti-arrhythmic action of class IC and class III drugs.
    Cardiovascular research, 2005, Jul-01, Volume: 67, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Electric Countershock; Electrophysiology; Flecainide; Goats; Models, Animal; Random Allocation; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Treatment Failure; Ventricular Remodeling

2005