ibutamoren-mesylate and piperidine

ibutamoren-mesylate has been researched along with piperidine* in 1 studies

Other Studies

1 other study(ies) available for ibutamoren-mesylate and piperidine

Article	Year
Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics. Bioorganic & medicinal chemistry letters, 2001, Jul-23, Volume: 11, Issue:14 A series of small molecules derived from MK-0677, a potent synthetic GHS, mimicking the N-terminal Gly-Ser-O-(n-octanoyl)-L-Ser-Phe segment of ghrelin was synthesized and tested in a binding and in a functional assay measuring intracellular calcium elevation in HEK-293 cells expressing hGHSR1a. Replacement of Phe in this tetrapeptide with a spiro(indoline-3,4'-piperidine) group, Gly-Ser with 2-aminoisobutyric acid, and O-(n-octanoyl)-L-Ser with O-benzyl-D-Ser provided synthetic GHS agonists with similar functional potency as ghrelin. Topics: Binding Sites; Calcium; Cells, Cultured; Ghrelin; Humans; Indoles; Inhibitory Concentration 50; Luminescence; Molecular Mimicry; Peptide Hormones; Peptides; Piperidines; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Spiro Compounds	2001

Article

Year

Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.

Bioorganic & medicinal chemistry letters, 2001, Jul-23, Volume: 11, Issue:14

A series of small molecules derived from MK-0677, a potent synthetic GHS, mimicking the N-terminal Gly-Ser-O-(n-octanoyl)-L-Ser-Phe segment of ghrelin was synthesized and tested in a binding and in a functional assay measuring intracellular calcium elevation in HEK-293 cells expressing hGHSR1a. Replacement of Phe in this tetrapeptide with a spiro(indoline-3,4'-piperidine) group, Gly-Ser with 2-aminoisobutyric acid, and O-(n-octanoyl)-L-Ser with O-benzyl-D-Ser provided synthetic GHS agonists with similar functional potency as ghrelin.

Topics: Binding Sites; Calcium; Cells, Cultured; Ghrelin; Humans; Indoles; Inhibitory Concentration 50; Luminescence; Molecular Mimicry; Peptide Hormones; Peptides; Piperidines; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Spiro Compounds

2001