ibuprofen and valproic acid

ibuprofen has been researched along with valproic acid in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.38)	18.7374
1990's	5 (11.90)	18.2507
2000's	15 (35.71)	29.6817
2010's	17 (40.48)	24.3611
2020's	4 (9.52)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Chang, TK; Ensom, MH; Kiang, TK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Higashida, H; Maeda, H; Ogihara, T; Sai, Y; Takanaga, H; Tamai, I; Tsuji, A	1
Buttar, HS; Guest, I; Smith, S; Varma, DR	1
Dasgupta, A; Volk, A	1
Mankin, KP; Scanlon, M	1
Iley, J; Mendes, E; Moreira, R; Souza, S	1
Kurz, M; Scriba, GK	1
Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M	1
Khan, AI; Lei, L; Norquist, AJ; O'Hare, D	1
Feng, R; Mandula, H; Parepally, JM; Smith, QR	1
Grillo, MP; Hua, F	1
Cheng, KW; Constantinides, PP; Rigas, B; Wong, CC; Xie, G; Zhou, D; Zhu, CH	1
Kołosowska, K; Lehner, M; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D	1
Ahmed Bijle, MN; Kamath, A; Kontham, U; Muchandi, S; Nankar, M; Walimbe, H	1
de Leon, J; Fuster, J; Lana, F; Martí-Bonany, J	1
Bain, LT; Flater, ML; Stephenson, JB	1
de Leon, J; Lana, F; Martí-Bonany, J	1
Akbas, I; Ceylan, M; Dogruyol, S; Gur, STA; Kocak, AO; Kocak, MB; Tekyol, D	1
Kanaoka, K; Kondo, Y; Suda, C; Watanabe, J	1
Chang, WJ; Ho, MP	1

Reviews

4 review(s) available for ibuprofen and valproic acid

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. Schmerz (Berlin, Germany), 2002, Volume: 16, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psychology; Child; Flunarizine; GABA Agents; Headache; Humans; Ibuprofen; Metoprolol; Migraine Disorders; Practice Guidelines as Topic; Propranolol; Relaxation Therapy; Serotonin Receptor Agonists; Sumatriptan; Tension-Type Headache; Valproic Acid; Vasodilator Agents	2002

Trials

1 trial(s) available for ibuprofen and valproic acid

Article	Year
Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department: A randomized clinical trial. The American journal of emergency medicine, 2022, Volume: 55 Topics: Double-Blind Method; Emergency Service, Hospital; Headache; Humans; Ibuprofen; Migraine Disorders; Prospective Studies; Treatment Outcome; Valproic Acid	2022

Other Studies

37 other study(ies) available for ibuprofen and valproic acid

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochemical and biophysical research communications, 1995, Sep-14, Volume: 214, Issue:2 Topics: Animals; Biological Transport; Carboxylic Acids; Carrier Proteins; CHO Cells; Cricetinae; Female; Hydrogen-Ion Concentration; Ibuprofen; Intestinal Mucosa; Lactates; Mandelic Acids; Membrane Proteins; Monocarboxylic Acid Transporters; Niacin; Oocytes; Pravastatin; Propionates; Protons; Rabbits; Recombinant Proteins; RNA, Complementary; RNA, Messenger; Stereoisomerism; Transcription, Genetic; Transfection; Valproic Acid; Xenopus laevis	1995
Evaluation of the rat embryo culture system as a predictive test for human teratogens. Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Captopril; Diphenhydramine; DNA; Embryo, Mammalian; False Negative Reactions; False Positive Reactions; Female; Humans; Ibuprofen; Neural Tube Defects; Organ Culture Techniques; Pregnancy; Rats; Teratogens; Valproic Acid	1994
Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions. Therapeutic drug monitoring, 1996, Volume: 18, Issue:3 Topics: Binding, Competitive; Blood Proteins; Carbamazepine; Cyclooxygenase Inhibitors; Drug Interactions; Humans; Ibuprofen; Naproxen; Protein Binding; Reference Values; Tolmetin; Uremia; Valproic Acid	1996
Side effect of ibuprofen and valproic acid. Orthopedics, 1998, Volume: 21, Issue:3 Topics: Adolescent; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Interactions; Epilepsy; Fractures, Closed; Humans; Ibuprofen; Male; Valproic Acid	1998
Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999, Volume: 9, Issue:2 Topics: Amides; Animals; Benzoic Acid; Carboxylic Acids; Clofibric Acid; Diclofenac; Drug Interactions; Esters; Hydrolases; Hydrolysis; Ibuprofen; In Vitro Techniques; Liver; Male; Naproxen; Physostigmine; Proadifen; Probenecid; Prodrugs; Rats; Rats, Sprague-Dawley; Refractometry; Solubility; Structure-Activity Relationship; Time Factors; Valproic Acid	1999
Drug-phospholipid conjugates as potential prodrugs: synthesis, characterization, and degradation by pancreatic phospholipase A(2). Chemistry and physics of lipids, 2000, Volume: 107, Issue:2 Topics: Hydrolysis; Ibuprofen; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pancreas; Phospholipases A; Phosphorylcholine; Prodrugs; Valproic Acid	2000
Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide. Chemical communications (Cambridge, England), 2001, Nov-21, Issue:22 Topics: Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Diclofenac; Gemfibrozil; Hydrogen-Ion Concentration; Hydroxides; Ibuprofen; Naproxen; ortho-Aminobenzoates; Phenylacetates; Valproic Acid	2001
Role of site-specific binding to plasma albumin in drug availability to brain. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:2 Topics: Animals; Binding, Competitive; Biological Availability; Brain; Ibuprofen; Male; Perfusion; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Serum Albumin; Tolbutamide; Ultrafiltration; Valproic Acid; Warfarin	2006
Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. Chemical research in toxicology, 2008, Volume: 21, Issue:9 Topics: Animals; Camphanes; Chromatography, Liquid; Glutathione; Hepatocytes; Ibuprofen; Lauric Acids; Male; Mass Spectrometry; Molecular Conformation; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfuric Acid Esters; Time Factors; Valproic Acid	2008
Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Survival; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; HEK293 Cells; Humans; Hydrolysis; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Naproxen; Nitrophenols; Organophosphates; Organophosphorus Compounds; Phenylglyoxal; Stomach Neoplasms; Sulindac; Transfection; Valproic Acid; Xenograft Model Antitumor Assays	2012
The kynurenine pathway: a missing piece in the puzzle of valproate action? Neuroscience, 2013, Mar-27, Volume: 234 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Ibuprofen; Kynurenic Acid; Kynurenine; Male; Rats; Signal Transduction; Tryptophan; Valproic Acid	2013
Comparative evaluation of cariogenic and erosive potential of commonly prescribed pediatric liquid medicaments: an in vitro study. The journal of contemporary dental practice, 2014, Jan-01, Volume: 15, Issue:1 Topics: Acetaminophen; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipyretics; Calcium; Cariogenic Agents; Dental Enamel; Dietary Supplements; Drug Combinations; Ferric Compounds; Humans; Hydrogen-Ion Concentration; Ibuprofen; Pharmaceutical Solutions; Solubility; Sucrose; Sweetening Agents; Tooth Erosion; Valproic Acid; Vitamins	2014
Reduction in serum concentration of valproic acid secondary to the intake of ibuprofen as an example of valproic acid auto-induction metabolism. Actas espanolas de psiquiatria, 2016, Volume: 44, Issue:4 Topics: Adult; Drug Interactions; Humans; Ibuprofen; Male; Valproic Acid	2016
Analysis of Valproic Acid, Salicylic Acid and Ibuprofen in Whole Blood by GC-MS. Journal of analytical toxicology, 2016, Volume: 40, Issue:8 Topics: Calibration; Gas Chromatography-Mass Spectrometry; Georgia; Humans; Ibuprofen; Limit of Detection; Molecular Weight; Reproducibility of Results; Salicylic Acid; Solid Phase Extraction; Tandem Mass Spectrometry; Valproic Acid	2016
Ibuprofen May Increase Pharmacological Action of Valproate by Displacing It From Plasma Proteins: A Case Report. The American journal of psychiatry, 2016, 09-01, Volume: 173, Issue:9 Topics: Antipsychotic Agents; Blood Proteins; Clozapine; Drug Synergism; Drug Therapy, Combination; Humans; Ibuprofen; Male; Schizophrenia; Valproic Acid; Young Adult	2016
Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department. The American journal of emergency medicine, 2022, Volume: 62 Topics: Anticonvulsants; Double-Blind Method; Emergency Service, Hospital; Humans; Ibuprofen; Migraine Disorders; Valproic Acid	2022
Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department. The American journal of emergency medicine, 2023, Volume: 65 Topics: Anticonvulsants; Double-Blind Method; Emergency Service, Hospital; Humans; Ibuprofen; Migraine Disorders; Valproic Acid	2023