ibuprofen has been researched along with rofecoxib in 92 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (7.61) | 18.2507 |
| 2000's | 72 (78.26) | 29.6817 |
| 2010's | 11 (11.96) | 24.3611 |
| 2020's | 2 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N | 1 |
| Amini, M; Habeeb, AG; Knaus, EE; Li, H; Praveen Rao, PN | 1 |
| Knaus, EE; Rao, PN; Uddin, MJ | 1 |
| Backlund, A; Bohlin, L; Gottfries, J; Larsson, J | 1 |
| Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Abdellatif, KR; Chowdhury, MA; Huang, Z; Kaufman, S; Knaus, EE | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bhardwaj, A; Huang, Z; Kaur, J; Knaus, EE; Sharma, SK; Wuest, F | 1 |
| Asif, M; Husain, A; Iqbal, MA; Iram, F; Khan, SA | 1 |
| Dallob, A; De Lepeleire, I; De Schepper, P; Ehrich, EW; Gertz, BJ; Mehlisch, DR; Porras, A; Riendeau, D; Seibold, JR; Van Hecken, A; Wittreich, J; Yuan, W | 1 |
| Bolognese, JA; Harper, SE; Hoover, ME; Lanza, FL; Quan, H; Rack, MF; Simon, TJ; Wilson, FR | 1 |
| Adcock, S; Bachmann, KA; Chan, CC; Cohen, RA; Davidson, MH; Dobratz, D; Gertz, BJ; Grasing, K; Hedges, J; Jones, TM; McBride, KJ; Moritz, C; Mukhopadhyay, S; Schwartz, JI | 1 |
| Amlani, S; Brown, J; Christensen, S; Morrison, BW; Seidenberg, B; Yuan, W | 1 |
| Bath, R; Bolognese, J; Harper, S; Johanson, J; Laine, L; Quan, H; Schwartz, H; Simon, T; Stern, S | 1 |
| Bolognese, JA; Harper, SE; Jensen, DM; Langman, MJ; Quan, H; Simon, TJ; Watson, DJ; Zhao, PL | 1 |
| Dionne, R | 1 |
| Acevedo, E; Beaulieu, A; Bolognese, J; Hawkey, C; Laine, L; Maldonado-Cocco, J; Mortensen, E; Quan, H; Shahane, A; Simon, T | 1 |
| Blondon, H | 1 |
| Bolognese, J; Castaneda, O; Daniels, B; Day, R; Ehrich, E; Helgetveit, KB; Kress, B; Krupa, D; Luza, A; Morrison, B; Nahir, M; Seidenberg, B; Strusberg, A | 1 |
| Bolognese, JA; Bowen, B; Cagliola, A; Hunt, RH; James, C; Mortensen, ER; Quan, H; Simon, TJ | 1 |
| Arnout, J; Buntinx, A; Dallob, A; De Lepeleire, I; De Schepper, PJ; Depré, M; Ebel, DL; Gertz, BJ; Schwartz, JI; Tanaka, W; Van Hecken, A; Wong, PH; Wynants, K | 1 |
| Bellamy, N; Bolognese, JA; Davies, GM; Ehrich, EW; Seidenberg, BC; Watson, DJ | 1 |
| Brown, J; Fricke, J; Kotey, P; Mehlisch, D; Morrison, BW; Yuan, W | 1 |
| Bolognese, JA; Harper, SE; Hawkey, CJ; Laine, L; Mortensen, E; Quan, HU | 1 |
| Browning, RA; Burgess, FW | 1 |
| Ouellet, M; Percival, MD; Riendeau, D | 1 |
| Catella-Lawson, F; Cucchiara, AJ; DeMarco, S; FitzGerald, GA; Kapoor, SC; Reilly, MP; Tournier, B; Vyas, SN | 1 |
| Barr, E; Reicin, AS; Shapiro, D; Sperling, RS; Yu, Q | 1 |
| Bridge, HS; Nolan, J; Pickering, AE; Stoddart, PA | 1 |
| Foral, PA; Nystrom, KK; Wilson, AF | 1 |
| Chandra, A; Nair, MG; Schutzki, R; Seeram, NP | 1 |
| Bolognese, JA; Harper, SE; Simon, TJ; Watson, DJ; Zhao, PL | 1 |
| Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS | 1 |
| Clifford, LJ; Dewitt, DL; Nair, MG; Rana, J | 1 |
| Pfeifer, M | 1 |
| Arbogast, PG; Daugherty, JR; Griffin, MR; Hall, K; Ray, WA; Stein, CM | 1 |
| Fricke, JR; Kotey, P; Kress, B; Malmstrom, K; Morrison, B | 1 |
| Carrasquer, G; Li, M | 1 |
| Gopikrishna, V; Parameswaran, A | 1 |
| Davies, JA; Mahajan, RP; Moppett, IK | 1 |
| Harley, C; Wagner, S | 1 |
| Burke, TA; Michaud, K; Wolfe, F; Zhao, SZ | 1 |
| García Rodríguez, LA; González-Pérez, A; Maguire, A; Varas-Lorenzo, C | 1 |
| Laine, L; Maller, ES; Quan, H; Simon, T; Yu, C | 1 |
| Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A | 1 |
| Dahlborg, R; Day, CA; Jacob, RF; Mason, RP; Walter, MF; Weng, Y | 1 |
| Illanes, M; Martín-Lacave, I; Motilva, V; Sánchez-Fidalgo, S | 1 |
| Jose, M; Kalita, J; Misra, UK | 1 |
| Hollenz, M; Labenz, J | 1 |
| Alarcón de la Lastra, C; Bruseghini, L; Manuel Herrerias, J; Motilva, V; Sánchez-Fidalgo, S | 1 |
| Berlin, JA; Chittams, J; Jaskowiak, J; Kimmel, SE; Kishel, L; Reilly, M; Strom, BL | 1 |
| Lucas, R; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Aizen, E; Assy, B; Bershadsky, Y; Gilhar, A; Iobel, R; Kagan, G | 1 |
| Albert, A; Chang, AJ; Liu, TC; Sangha, S; Wolfe, MM; Yao, M; Zhou, W | 1 |
| Cheung, LK; Chiu, WK | 1 |
| Edwards, JE; McQuay, HJ; Moore, RA | 1 |
| Beata, RN; Ryszard, M; Stanisław, S; Wojciech, F | 1 |
| McCarthy, DM | 1 |
| Meechan, J | 1 |
| Barnes, PJ; Ciabattoni, G; Ciappi, G; Kharitonov, SA; Lauriola, L; Macagno, F; Montuschi, P; Parente, P; Valente, S | 1 |
| Holt, CI; Hutchins, MO; Pileggi, R | 1 |
| Beaulieu, P; Guindon, J | 1 |
| Barraclough, E; Dahlof, C; Klipfel, M; Lines, C; Loeys, T; Malbecq, W; Reines, S; Saper, J; So, Y; Tfelt-Hansen, P; Visser, H; Yuen, E | 1 |
| Dionne, RA; Lee, YS; Wang, XM; Wu, TX | 1 |
| García Rodríguez, LA; Hernández-Díaz, S; Varas-Lorenzo, C | 1 |
| Chan, P; Holder, AP; Hovsepian, DM; Mandava, A; Patel, T; Pilgram, TK; Wong, V | 1 |
| Jarnagin, K; Kolaja, K; Pearson, CI; Sagartz, J; Tugendreich, S | 1 |
| Dionne, RA; Kim, H; Lee, YS; Wang, XM; Wu, TX | 1 |
| Abildstrom, SZ; Buch, P; Friberg, J; Gislason, GH; Jacobsen, S; Køber, L; Madsen, M; Rasmussen, JN; Rasmussen, S; Schramm, TK; Torp-Pedersen, C | 1 |
| Barner, JC; Busti, AJ; Lawson, KA; Motsko, SP; Rascati, KL; Wilson, JP; Worchel, J | 1 |
| Haglund, B; von Bültzingslöwen, I | 1 |
| Kevelham, E; Morse, Z; Tump, A | 1 |
| Beaulieu, P; De Léan, A; Guindon, J; LoVerme, J; Piomelli, D | 1 |
| Dionne, RA; Hamza, M; Ramsay, ES; Wahl, SM; Wang, XM; Wu, TX | 1 |
| Brookhart, MA; Rassen, J; Schneeweiss, S; Solomon, DH; Wang, PS | 1 |
| Kong, SX; LeLorier, J; Rahme, E; Toubouti, Y; Watson, DJ | 1 |
| Alshafie, GA; Beebe-Donk, J; Harris, RE | 1 |
| Singh, H | 1 |
| Bontempo, N; Capo, JT; Cottrell, JA; Manigrasso, MB; O'Connor, JP; Parsons, JR; Tan, V | 1 |
| Arbogast, PG; Castellsague, J; Chung, CP; Daugherty, JR; García-Rodríguez, LA; Murray, KT; Ray, WA; Stein, CM; Varas-Lorenzo, C | 1 |
| Capo, J; Cottrell, JA; Meyenhofer, M; Nourbakhsh, A; O'Connor, JP; Tan, V | 1 |
| Matteson, EL; Thongprayoon, C; Ungprasert, P | 1 |
| Choi, HK; Dalal, DS; Dubreuil, M; Felson, DT; Lee, T; Lu, N; Zhang, Y | 1 |
| Anderson, B; Cooper, TE; Eccleston, C; Fisher, E; Wilkinson, NM | 1 |
| Gislason, G; Sondergaard, KB | 1 |
| Aalfs, AS; Bouwman, K; Kruithof, I; Menichino, S | 1 |
| Hjemdahl, P; Stiller, CO | 1 |
9 review(s) available for ibuprofen and rofecoxib
| Article | Year |
|---|---|
Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Molecular Structure | 2019 |
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Nabumetone; Osteoarthritis; Peptic Ulcer; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Randomized Controlled Trials as Topic; Sulfones | 1999 |
Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ibuprofen; Lactones; Pain; Pain Measurement; Randomized Controlled Trials as Topic; Reaction Time; Sulfones; Time Factors; Treatment Outcome | 2005 |
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gastrointestinal Hemorrhage; Helicobacter Infections; Humans; Ibuprofen; Lactones; Naproxen; Peptic Ulcer; Risk Factors; Sulfones | 2002 |
Non-steroidal antiinflammatory drugs and the risk of acute myocardial infarction.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cohort Studies; Diclofenac; Dose-Response Relationship, Drug; Humans; Ibuprofen; Lactones; Myocardial Infarction; Naproxen; Risk Factors; Sulfones | 2006 |
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles | 2016 |
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Celecoxib; Child; Child, Preschool; Chronic Disease; Chronic Pain; Fenoprofen; Humans; Ibuprofen; Lactones; Meloxicam; Methoxsalen; Naproxen; Randomized Controlled Trials as Topic; Sulfones; Thiazines; Thiazoles | 2017 |
Two new cases of aquagenic wrinkling of the palms and literature review on drug interactions.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Female; Hand; Humans; Ibuprofen; Immersion; Lactones; Male; Skin; Sulfones; Water | 2020 |
Lessons from 20 years with COX-2 inhibitors: Importance of dose-response considerations and fair play in comparative trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Fibrinolytic Agents; Humans; Ibuprofen; Lactones; Naproxen; Prostaglandins; Prostaglandins I; Sulfones; Thromboxanes | 2022 |
31 trial(s) available for ibuprofen and rofecoxib
| Article | Year |
|---|---|
Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model.
Topics: Adult; Analgesics, Non-Narcotic; Animals; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Indomethacin; Isoenzymes; Lactones; Male; Models, Biological; Pain; Prostaglandin-Endoperoxide Synthases; Sulfones; Tooth | 1999 |
Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Enzyme Inhibitors; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Stomach Ulcer; Sulfones; Thromboxanes | 1999 |
Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Temperature; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Administration Schedule; Fever; Ibuprofen; Isoenzymes; Lactones; Lipopolysaccharides; Prostaglandin-Endoperoxide Synthases; Saimiri; Sulfones; Treatment Outcome | 1999 |
Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: a randomized, controlled trial.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Molar, Third; Pain, Postoperative; Placebos; Prostaglandin-Endoperoxide Synthases; Substrate Specificity; Sulfones; Tooth Extraction | 1999 |
A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Rofecoxib Osteoarthritis Endoscopy Study Group.
Topics: Aged; Aged, 80 and over; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Female; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Intestinal Mucosa; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Stomach Ulcer; Sulfones | 1999 |
Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multina
Topics: Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Duodenum; Enzyme Inhibitors; Gastric Mucosa; Humans; Ibuprofen; Incidence; Intestinal Mucosa; Lactones; Placebos; Sulfones | 2000 |
[Specific cyclo-oxygenase inhibitors. 2. Gastric toxicity?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhibitors; Duodenoscopy; Esophagoscopy; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Lactones; Osteoarthritis; Peptic Ulcer; Placebos; Pyrazoles; Sulfonamides; Sulfones; Time Factors | 2000 |
A randomized trial of the efficacy and tolerability of the COX-2 inhibitor rofecoxib vs ibuprofen in patients with osteoarthritis. Rofecoxib/Ibuprofen Comparator Study Group.
Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Osteoarthritis; Sulfones; Treatment Outcome | 2000 |
A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromium Radioisotopes; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Erythrocytes; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Occult Blood; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Radionuclide Imaging; Radiopharmaceuticals; Reference Values; Sulfones; Treatment Outcome | 2000 |
Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.
Topics: Adolescent; Adult; Bleeding Time; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Lipopolysaccharides; Meloxicam; Membrane Proteins; Middle Aged; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfones; Thiazines; Thiazoles; Thromboxane B2 | 2000 |
Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities osteoarthritis index questionnaire and global assessments in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Health Status; Humans; Ibuprofen; Lactones; Male; Middle Aged; Multicenter Studies as Topic; Osteoarthritis; Outcome Assessment, Health Care; Pain Measurement; Randomized Controlled Trials as Topic; Severity of Illness Index; Sulfones; Surveys and Questionnaires | 2000 |
The optimal analgesic dose of rofecoxib: Overview of six randomized controlled trials.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Molar, Third; Naproxen; Pain Measurement; Pain, Postoperative; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Statistics, Nonparametric; Sulfones; Survival Analysis; Time Factors; Tooth Extraction | 2000 |
Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials.
Topics: Aged; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Osteoarthritis; Peptic Ulcer Hemorrhage; Peptic Ulcer Perforation; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Risk Factors; Stomach Ulcer; Sulfones | 2001 |
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Interactions; Drug Therapy, Combination; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2 | 2001 |
Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children.
Topics: Acetaminophen; Adenoidectomy; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Child; Child, Preschool; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ibuprofen; Infant; Lactones; Male; Pain, Postoperative; Premedication; Sulfones; Tonsillectomy | 2002 |
A comparison of rofecoxib versus celecoxib in treating pain after dental surgery: a single-center, randomized, double-blind, placebo- and active-comparator-controlled, parallel-group, single-dose study using the dental impaction pain model.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction | 2002 |
Effectiveness of prophylactic use of rofecoxib in comparison with ibuprofen on postendodontic pain.
Topics: Acute Disease; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Pain Measurement; Pain, Postoperative; Periapical Periodontitis; Prostaglandin-Endoperoxide Synthases; Pulpectomy; Root Canal Preparation; Statistics, Nonparametric; Sulfones; Toothache | 2003 |
Non-selective and cyclo-oxygenase-2-specific non-steroidal anti-inflammatory drugs impair the hyperaemic response of skin to brief axillary artery occlusion.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Axillary Artery; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Forearm; Humans; Hyperemia; Ibuprofen; Isoenzymes; Lactones; Laser-Doppler Flowmetry; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Regional Blood Flow; Skin; Sulfones; Vasodilation | 2003 |
Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Gastric Mucosa; Humans; Ibuprofen; Incidence; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Risk Factors; Stomach Ulcer; Sulfones; Tablets, Enteric-Coated | 2004 |
Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial.
Topics: Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Migraine Disorders; Sulfones; Treatment Outcome | 2004 |
Effect of non-steroidal anti-inflammatory drugs on natural killer cell activity in patients with dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Infarction; Dementia, Vascular; Disease Progression; Female; Humans; Ibuprofen; Killer Cells, Natural; Lactones; Male; Prospective Studies; Sulfones | 2005 |
Efficacy of preoperative oral rofecoxib in pain control for third molar surgery.
Topics: Administration, Oral; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Facial Pain; Female; Humans; Ibuprofen; Lactones; Male; Molar, Third; Pain Measurement; Pain, Postoperative; Preoperative Care; Prospective Studies; Statistics, Nonparametric; Sulfones; Tooth Extraction | 2005 |
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction | 2006 |
Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD.
Topics: Blood Gas Analysis; Cross-Over Studies; Cyclooxygenase Inhibitors; Dinoprostone; Double-Blind Method; Eicosanoids; Female; Forced Expiratory Volume; Humans; Ibuprofen; Lactones; Leukotriene B4; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Sputum; Sulfones; Thromboxane B2; Vital Capacity | 2005 |
Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Migraine Disorders; Nausea; Serotonin Receptor Agonists; Sulfones; Treatment Outcome | 2006 |
Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors.
Topics: Adolescent; Adult; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Gene Expression Regulation; Humans; Ibuprofen; Interleukin-8; Lactones; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Postoperative Period; Reverse Transcriptase Polymerase Chain Reaction; Sulfones; Tissue Inhibitor of Metalloproteinase-3; Tissue Plasminogen Activator | 2006 |
Comparison of adjunctive use of rofecoxib versus ibuprofen in the management of postoperative pain after uterine artery embolization.
Topics: Adult; Aged; Chi-Square Distribution; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Embolization, Therapeutic; Female; Humans; Ibuprofen; Lactones; Middle Aged; Narcotics; Pain Measurement; Pain, Postoperative; Radiography, Interventional; Sulfones; Treatment Outcome; Uterus | 2006 |
Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs.
Topics: Adolescent; Adult; Aged; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Haplotypes; Humans; Ibuprofen; Lactones; Male; Membrane Proteins; Middle Aged; Pain, Postoperative; Pharmacogenetics; Polymorphism, Single Nucleotide; Sulfones | 2006 |
Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute pain relief after third molar surgery: a randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cohort Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Follow-Up Studies; Humans; Ibuprofen; Lactones; Male; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Placebos; Sulfones; Tooth Extraction; Treatment Outcome | 2006 |
Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Premedication; Prospective Studies; Statistics, Nonparametric; Sulfones; Tooth Extraction | 2006 |
Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain.
Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Cytokines; Female; Gene Expression; Gene Expression Regulation; Humans; Ibuprofen; Immunologic Factors; Inflammation; Lactones; Male; Pain; Signal Transduction; Sulfones | 2007 |
52 other study(ies) available for ibuprofen and rofecoxib
| Article | Year |
|---|---|
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors | 2003 |
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Edema; Isoenzymes; Membrane Proteins; Models, Molecular; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrans; Pyrones; Rats; Structure-Activity Relationship; Sulfones | 2003 |
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Isoenzymes; Membrane Proteins; Models, Molecular; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrans; Pyrones; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfones | 2004 |
Expanding the ChemGPS chemical space with natural products.
Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship | 2005 |
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhibitors; Drug Design; Edema; Female; Foot; Formaldehyde; Inflammation; Male; Rats; Rats, Sprague-Dawley; Thiazoles | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.
Topics: 4-Butyrolactone; Animals; Cyclooxygenase 2 Inhibitors; Esters; Inhibitory Concentration 50; Mesenteric Arteries; Molecular Structure; Nitric Oxide Donors; Prodrugs; Rats; Sulfones; Triazenes | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.
Topics: Acridines; Acridones; Biomarkers, Tumor; Celecoxib; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Fluorescent Dyes; Humans; Ibuprofen; Microscopy, Confocal; Protein Binding; Pyrazoles; Rhodamines; Structure-Activity Relationship; Sulfonamides | 2013 |
COX-2 inhibitors: better than ibuprofen for dental pain?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Toothache | 1999 |
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors | 2001 |
A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin.
Topics: Acetylation; Animals; Aspirin; Blood Platelets; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Humans; Ibuprofen; In Vitro Techniques; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sheep; Sulfonamides; Sulfones | 2001 |
[Side effects cause enormous costs. Expensive arthritis therapy].
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Drug Costs; Gastrointestinal Diseases; Humans; Ibuprofen; Lactones; Nabumetone; Patient Satisfaction; Pyrazoles; Sulfonamides; Sulfones | 2001 |
Comparison of cardiovascular thrombotic events in patients with osteoarthritis treated with rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs (ibuprofen, diclofenac, and nabumetone).
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cardiovascular Diseases; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diclofenac; Female; Humans; Ibuprofen; Incidence; Lactones; Male; Middle Aged; Nabumetone; Osteoarthritis; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk; Sulfones; Thrombosis; Treatment Outcome | 2002 |
Gastrointestinal bleeds associated with rofecoxib.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Gastrointestinal Hemorrhage; Hematemesis; Humans; Ibuprofen; Lactones; Laminectomy; Male; Melena; Middle Aged; Pain, Postoperative; Sulfones | 2002 |
Characterization, quantification, and bioactivities of anthocyanins in Cornus species.
Topics: Anthocyanins; Antioxidants; Celecoxib; Chromatography, High Pressure Liquid; Cornus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fruit; Ibuprofen; Isoenzymes; Lactones; Naproxen; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones | 2002 |
Gastrointestinal medications and procedures in osteoarthritis patients treated with rofecoxib compared with nonselective NSAIDs.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Lactones; Male; Middle Aged; Nabumetone; Osteoarthritis; Randomized Controlled Trials as Topic; Sulfones | 2001 |
A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Edema; Female; Humans; Hypertension; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Nabumetone; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Renal Circulation; Safety; Sulfones | 2002 |
Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench.
Topics: Aedes; Amides; Animals; Anti-Inflammatory Agents; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Echinacea; Ibuprofen; Isoenzymes; Lactones; Lethal Dose 50; Naproxen; Phytotherapy; Plant Extracts; Plant Roots; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones | 2002 |
[Analgesic in osteoporosis. Why so conservative with dosage?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Humans; Ibuprofen; Lactones; Middle Aged; Osteoporosis; Pyrazoles; Risk Factors; Sulfonamides; Sulfones | 2002 |
COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Coronary Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Medicaid; Membrane Proteins; Middle Aged; Naproxen; Product Surveillance, Postmarketing; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Regression Analysis; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones; Tennessee | 2002 |
Effect of ibuprofen and rofecoxib transport parameters in the frog corneal epithelium.
Topics: Animals; Dose-Response Relationship, Drug; Epithelium, Corneal; Ibuprofen; In Vitro Techniques; Lactones; Membrane Potentials; Rana catesbeiana; Reproducibility of Results; Sensitivity and Specificity; Sulfones | 2002 |
[Rapid, strong and long-term effectiveness. Coxib also effective in toothache].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones; Tooth Extraction; Toothache; Treatment Outcome | 2003 |
Persistence with COX-2 inhibitors in managed care: an analysis of claims data.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Utilization Review; Female; Health Care Costs; Humans; Ibuprofen; Insurance Claim Review; Isoenzymes; Lactones; Male; Managed Care Programs; Membrane Proteins; Middle Aged; Naproxen; Patient Compliance; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Regression Analysis; Sulfonamides; Sulfones; United States | 2003 |
Longer use of COX-2-specific inhibitors compared to nonspecific nonsteroidal antiinflammatory drugs: a longitudinal study of 3639 patients in community practice.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Community Health Services; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Fibromyalgia; Follow-Up Studies; Humans; Ibuprofen; Isoenzymes; Lactones; Longitudinal Studies; Male; Membrane Proteins; Middle Aged; Naproxen; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Surveys and Questionnaires | 2004 |
Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Case-Control Studies; Cohort Studies; Comorbidity; Coronary Disease; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Drug Utilization; Female; Follow-Up Studies; Humans; Ibuprofen; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Odds Ratio; Risk Factors; Spain; Sulfones | 2004 |
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flurbiprofen; Ibuprofen; Isoenzymes; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thrombosis | 2004 |
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs.
Topics: Animals; Antioxidants; Celecoxib; Cholesterol, LDL; Chromans; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Isoprostanes; Isoxazoles; Lactones; Meloxicam; Naproxen; Oxidation-Reduction; Pyrazoles; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2004 |
Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fibroblast Growth Factor 2; Ibuprofen; Immunohistochemistry; Lactones; Male; Neovascularization, Physiologic; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfones; Vascular Endothelial Growth Factor A; Wound Healing | 2004 |
[Gastrointestinal complications under NSAID treatment in the doctor's office].
Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Clinical Trials as Topic; Diclofenac; Dose-Response Relationship, Drug; Dyspepsia; Endoscopy, Digestive System; Humans; Ibuprofen; Lactones; Peptic Ulcer; Smoking; Spondylitis; Sulfones | 2004 |
COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions.
Topics: Acetic Acid; Acute Disease; Animals; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Hydrochloric Acid; Ibuprofen; Lactones; Male; Membrane Proteins; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfones | 2005 |
Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bias; Case-Control Studies; Celecoxib; Confounding Factors, Epidemiologic; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Odds Ratio; Pyrazoles; Risk Factors; Sulfonamides; Sulfones | 2005 |
Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Line; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Activation; Humans; Ibuprofen; Indomethacin; Lactones; Lung; Naproxen; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Sulfones; tert-Butylhydroperoxide; Transcription, Genetic | 2005 |
Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Fluorouracil; HT29 Cells; Humans; Ibuprofen; Irinotecan; Lactones; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Prostaglandin-Endoperoxide Synthases; Sulfones; Survival Analysis; Xenograft Model Antitumor Assays | 2005 |
The influence of anti-inflammatory drugs on the proliferation of fibroblast derived from nasal polyps.
Topics: Anti-Inflammatory Agents; Budesonide; Cell Proliferation; Cells, Cultured; Fibroblasts; Humans; Ibuprofen; Lactones; Nasal Polyps; Sulfonamides; Sulfones | 2005 |
A real time quantitative PCR analysis and correlation of COX-1 and COX-2 enzymes in inflamed dental pulps following administration of three different NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dental Pulp Exposure; Ibuprofen; Lactones; Male; Pulpitis; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Sulfones | 2005 |
Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endocannabinoids; Hyperalgesia; Ibuprofen; Lactones; Male; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sciatic Neuropathy; Sulfones | 2006 |
NSAID-induced acute phase response is due to increased intestinal permeability and characterized by early and consistent alterations in hepatic gene expression.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CCL2; Chemokines, CXC; Cyclooxygenase 2 Inhibitors; Databases, Factual; Dose-Response Relationship, Drug; Gene Expression; Ibuprofen; Indomethacin; Intestinal Mucosa; Intestines; Lactones; Lipopolysaccharides; Liver; Male; Permeability; Rats; Rats, Sprague-Dawley; Sulfones; Time Factors | 2006 |
Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs after acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Confidence Intervals; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Denmark; Diclofenac; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Patient Readmission; Proportional Hazards Models; Pyrazoles; Recurrence; Registries; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones | 2006 |
Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk.
Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Etodolac; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Naproxen; Pyrazoles; Sulfonamides; Sulfones; Time Factors; United States; Veterans | 2006 |
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Edema; Endocannabinoids; Formaldehyde; Ibuprofen; Lactones; Male; Mass Spectrometry; Nitrobenzenes; Pain Measurement; Peripheral Nervous System; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sulfonamides; Sulfones; TRPV Cation Channels | 2006 |
Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Lactones; Male; Multivariate Analysis; Myocardial Infarction; Naproxen; Pyrazoles; Rheumatic Diseases; Risk Assessment; Risk Factors; Sulfonamides; Sulfones | 2006 |
Association between nonnaproxen NSAIDs, COX-2 inhibitors and hospitalization for acute myocardial infarction among the elderly: a retrospective cohort study.
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Prescriptions; Drug Utilization; Female; Hospitalization; Humans; Ibuprofen; Lactones; Male; Myocardial Infarction; Product Surveillance, Postmarketing; Proportional Hazards Models; Pyrazoles; Quebec; Retrospective Studies; Sex Factors; Sulfonamides; Sulfones | 2007 |
New warnings about painkillers, new advice on what you can do.
Topics: Antacids; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Drug Interactions; Humans; Ibuprofen; Lactones; Naproxen; Sulfones | 2006 |
Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Celecoxib; Chemoprevention; Cyclooxygenase 2 Inhibitors; Female; Humans; Ibuprofen; Lactones; Logistic Models; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Ohio; Pyrazoles; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones | 2007 |
Treating osteoarthritis in the elderly: should recent data on NSAIDs change our way of practice?
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Databases, Factual; Diclofenac; Gastrointestinal Diseases; Humans; Ibuprofen; Kidney Diseases; Lactones; Myocardial Infarction; Osteoarthritis; Retrospective Studies; Sulfones | 2007 |
A comparison of the effects of ibuprofen and rofecoxib on rabbit fibula osteotomy healing.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Cyclooxygenase 2 Inhibitors; Fibula; Fracture Healing; Fractures, Bone; Ibuprofen; Lactones; Male; Osteotomy; Rabbits; Sulfones | 2009 |
Cardiovascular risks of nonsteroidal antiinflammatory drugs in patients after hospitalization for serious coronary heart disease.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cohort Studies; Coronary Artery Disease; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Follow-Up Studies; Hospitalization; Humans; Ibuprofen; Incidence; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Outpatients; Pyrazoles; Retrospective Studies; Risk Factors; Stroke; Sulfonamides; Sulfones; Tennessee | 2009 |
Effects of nonsteroidal anti-inflammatory drugs on flexor tendon adhesion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Forelimb; Ibuprofen; Lactones; Male; Rabbits; Sulfones; Tendons; Tissue Adhesions; Wound Healing | 2010 |
Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Lactones; Logistic Models; Male; Meloxicam; Middle Aged; Naproxen; Odds Ratio; Osteoarthritis, Knee; Risk Factors; Sulfones; Thiazines; Thiazoles; Treatment Outcome; United Kingdom; Venous Thromboembolism | 2016 |
NSAIDs and cardiac arrest: Non-steroidal anti-inflammatory drug use is associated with increased risk of Out-of-hospital Cardiac Arrest: A nationwide Case-Time-Control study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Celecoxib; Denmark; Humans; Ibuprofen; Lactones; Naproxen; Out-of-Hospital Cardiac Arrest; Risk Factors; Sulfones | 2017 |