ibuprofen and mannitol

ibuprofen has been researched along with mannitol in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's1 (3.23)18.2507
2000's9 (29.03)29.6817
2010's16 (51.61)24.3611
2020's4 (12.90)2.80

Authors

AuthorsStudies
Duffy, EM; Jorgensen, WL1
Faassen, F; Spanings, H; Vogel, G; Vromans, H1
Caron, G; Ermondi, G1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Bhatia, G; Khanna, AK; Kumar, M; Modukuri, RK; Rai, S; Sashidhara, KV; Shukla, R; Sonkar, R1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Caplan, M; Hess, ML; Lucchesi, B; Romson, JL; Rowe, GT1
Ford, J; Houston, JB; Martin, SW1
Candiani, C; Giorgini, A; Mandelli, G; Podda, M; Sacchetta, AC; Selmi, C; Zermiani, P; Zuin, M1
Abatzoglou, N; Benedetti, C; Cartilier, L; Léonard, G; McDermott, L; Simard, JS1
Pabari, RM; Ramtoola, Z1
Busignies, V; Diarra, H; Mazel, V; Tchoreloff, P1
Al-Khattawi, A; Alyami, H; Ma, X; Mohammed, AR; Townsend, B1
Stebbins, ND; Uhrich, KE; Yu, W1
Holm, R; Lagunas, C; Mo, J; Nielsen, CU; Noori, B; Nøhr, MK; Rasmussen, RN1
Paul, S; Sun, CC1
Afrose, A; George, G; Howes, T; Islam, N; Rashid, A; Rintoul, L; White, ET1
Healy, AM; Madi, AM; O'Connell, P; Serrano, DR; Twamley, B; Walsh, D; Worku, ZA1
Korhonen, O; Laitinen, R; Ojarinta, R; Saarinen, J; Strachan, CJ1
Eda, T; Kagawa, Y; Miyazaki, Y; Uchino, T1
Ivone, R; Lin, X; Shen, J; Wang, X; Xie, L; Yang, G; Yang, Y1
Berkenkemper, S; Keizer, HL; Kleinebudde, P; Lindenberg, M; Szepes, A1
Breitkreutz, J; Kokott, M; Lura, A; Wiedey, R1

Reviews

1 review(s) available for ibuprofen and mannitol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for ibuprofen and mannitol

ArticleYear
Gastrointestinal tolerability of ibuprofen administered in two pharmaceutical formulations.
    Arzneimittel-Forschung, 2000, Volume: 50, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Female; Gastric Mucosa; Gastrointestinal Diseases; Humans; Ibuprofen; Intestinal Mucosa; Lactulose; Male; Mannitol; Middle Aged; Occult Blood; Permeability; Sucrose

2000

Other Studies

29 other study(ies) available for ibuprofen and mannitol

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
    International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport

2003
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.
    Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcone; Coumarins; Edema; Microsomes; Rats

2011
Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Limitation of infarct size with neutrophil inhibition and depletion.
    Advances in myocardiology, 1985, Volume: 5

    Topics: Adenosine Triphosphatases; Animals; Butylated Hydroxytoluene; Calcium; Catalase; Dogs; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Ibuprofen; Indomethacin; Leukocytes; Male; Mannitol; Myocardial Infarction; Myocardium; Neutrophils; Sarcoplasmic Reticulum; Superoxide Dismutase; Tetradecanoylphorbol Acetate

1985
Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat.
    Journal of pharmacological and toxicological methods, 1995, Volume: 34, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbon Radioisotopes; Cell Membrane Permeability; Chromium Radioisotopes; Dose-Response Relationship, Drug; Edetic Acid; Ibuprofen; Intestines; Inulin; Lactulose; Male; Mannitol; Methods; Peptic Ulcer; Piroxicam; Rats; Rats, Sprague-Dawley; Tritium

1995
Cohesive, multicomponent, dense powder flow characterization by NIR.
    International journal of pharmaceutics, 2007, May-24, Volume: 336, Issue:2

    Topics: Calibration; Chemistry, Pharmaceutical; Excipients; Ibuprofen; Least-Squares Analysis; Mannitol; Models, Statistical; Multivariate Analysis; Powders; Reproducibility of Results; Rheology; Spectroscopy, Near-Infrared; Technology, Pharmaceutical

2007
Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets.
    International journal of pharmaceutics, 2012, Jul-01, Volume: 430, Issue:1-2

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Calcium Compounds; Chemistry, Pharmaceutical; Compressive Strength; Excipients; Factor Analysis, Statistical; Hardness; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Kinetics; Linear Models; Mannitol; Models, Chemical; Particle Size; Porosity; Reproducibility of Results; Silicates; Solubility; Starch; Tablets; Technology, Pharmaceutical

2012
On the links between elastic constants and effective elastic behavior of pharmaceutical compacts: importance of poisson's ratio and use of bulk modulus.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:11

    Topics: Analgesics, Non-Narcotic; Calcium Phosphates; Cellulose; Drug Compounding; Elastic Modulus; Ibuprofen; Mannitol; Powders; Stress, Mechanical; Tablets

2013
Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Cellulose; Chemistry, Pharmaceutical; Drug Compounding; Excipients; Ibuprofen; Mannitol; Tablets; Theophylline

2014
Linear, Mannitol-Based Poly(anhydride-esters) with High Ibuprofen Loading and Anti-Inflammatory Activity.
    Biomacromolecules, 2015, Nov-09, Volume: 16, Issue:11

    Topics: 3T3 Cells; Animals; Anti-Inflammatory Agents; Biocompatible Materials; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Delivery Systems; Elastomers; Fibroblasts; Ibuprofen; Mannitol; Mice; Polyesters; Polymers; Spectroscopy, Fourier Transform Infrared

2015
A Transporter of Ibuprofen is Upregulated in MDCK I Cells under Hyperosmotic Culture Conditions.
    Molecular pharmaceutics, 2016, 09-06, Volume: 13, Issue:9

    Topics: Animals; Cell Line; Dogs; Ibuprofen; Madin Darby Canine Kidney Cells; Mannitol; Membrane Transport Proteins; Osmolar Concentration; Raffinose; Sodium Chloride; Urea

2016
The suitability of common compressibility equations for characterizing plasticity of diverse powders.
    International journal of pharmaceutics, 2017, Oct-30, Volume: 532, Issue:1

    Topics: Algorithms; Calcium Phosphates; Celecoxib; Cellulose; Compressive Strength; Excipients; Hardness; Ibuprofen; Lactose; Mannitol; Powders; Stearic Acids

2017
Preparation of Ibuprofen Microparticles by Antisolvent Precipitation Crystallization Technique: Characterization, Formulation, and In Vitro Performance.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Precipitation; Crystallization; Drug Compounding; Excipients; Freeze Drying; Hypromellose Derivatives; Ibuprofen; Leucine; Mannitol; Particle Size; Poloxamer; Solubility; Solvents; Spectrum Analysis, Raman

2018
Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion.
    International journal of pharmaceutics, 2018, Nov-15, Volume: 551, Issue:1-2

    Topics: Crystallization; Desiccation; Drug Compounding; Excipients; Hot Temperature; Ibuprofen; Mannitol; Niacinamide; Polyethylene Glycols; Polyvinyls; Pyrrolidines; Xylitol

2018
Preparation and characterization of multi-component tablets containing co-amorphous salts: Combining multimodal non-linear optical imaging with established analytical methods.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 132

    Topics: Administration, Oral; Arginine; Chemistry, Pharmaceutical; Drug Combinations; Drug Stability; Excipients; Ibuprofen; Indomethacin; Mannitol; Optical Imaging; Povidone; Salts; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; Technology, Pharmaceutical; X-Ray Diffraction; Xylitol

2018
Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer.
    Chemical & pharmaceutical bulletin, 2020, Volume: 68, Issue:3

    Topics: Calorimetry, Differential Scanning; Centrifugation; Ibuprofen; Lactose; Mannitol; Particle Size; Powder Diffraction; Starch; Surface Properties

2020
A tunable extruded 3D printing platform using thermo-sensitive pastes.
    International journal of pharmaceutics, 2020, Jun-15, Volume: 583

    Topics: Cellulose; Delayed-Action Preparations; Diclofenac; Excipients; Gelatin; Glycerol; Hydrodynamics; Hypromellose Derivatives; Ibuprofen; Lactose; Mannitol; Printing, Three-Dimensional; Rheology; Technology, Pharmaceutical; Viscosity; Water

2020
Functionality of disintegrants with different mechanisms after roll compaction.
    International journal of pharmaceutics, 2020, Jun-30, Volume: 584

    Topics: Carboxymethylcellulose Sodium; Cellulose; Drug Compounding; Excipients; Ibuprofen; Mannitol; Povidone; Sodium Dodecyl Sulfate; Solubility; Tablets; Tensile Strength

2020
Evaluation of two novel co-processed excipients for direct compression of orodispersible tablets and mini-tablets.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2021, Volume: 168

    Topics: Acetaminophen; Chemistry, Pharmaceutical; Drug Compounding; Enalapril; Excipients; Ibuprofen; Mannitol; Tablets; Tensile Strength

2021