ibuprofen and ketorolac

ibuprofen has been researched along with ketorolac in 76 studies

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.32)18.7374
1990's14 (18.42)18.2507
2000's19 (25.00)29.6817
2010's31 (40.79)24.3611
2020's11 (14.47)2.80

Authors

AuthorsStudies
Bell, MR; D'Ambra, TE; Daum, SJ; Eissenstat, MA; Herrmann, JL; Hlasta, DJ; Kumar, V; Philion, RE; Rosi, D; Wetzel, JR1
Topliss, JG; Yoshida, F1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Chuang, S; Horne, J; Porter, CJ; Scanlon, MJ; Velkov, T1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cabrita, EJ; Corvo, MC; Manso, J; Marques, MM; Viegas, A1
Kumar, M; Sinha, VR; Thareja, S1
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C1
Bellman, K; Knegtel, RM; Settimo, L1
Headey, SJ; Hughes, ML; Laguerre, A; Mohanty, B; Patil, R; Porter, CJ; Scanlon, MJ; Wielens, J; Williams, ML1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, TA; Nakagawa, A; Smith, CE; Soti, S; Xue, D; Yin, H1
Gasparich, JP; Mayo, ME1
Paris, PM; Seaberg, DC; Turturro, MA1
Blumenthal, PD; Furman, WR; Givogre, JL; Higgins, MS; Marco, AP1
Morrison, NA; Repka, MX1
Price, SD; Watson, WA; Wright, JM1
Balevi, B1
Rømsing, J; Walther-Larsen, S1
Frölich, JC; Stichtenoth, DO1
Todd, KH1
Michael, LR; Southall, DM; Vasko, RM1
Hall, SR; Loomis, C; Milne, B1
Fowler, CJ; Janson, U; Johnson, RM; Norström, K; Stenström, A; Tiger, G; Wahlström, G1
Browne, GS; Day, RO; Ellis, BA; Nelson, C; Nguyen, T; Williams, KM1
Bell, A; Hosokawa, A; Jhamandas, K; Milne, B; Powell, KJ; Quirion, R; Sutak, M1
Junger, H; Sorkin, LS1
Bozzo, J; Escolar, G; Galán, AM; Hernández, MR; Ordinas, A1
Browning, RA; Burgess, FW1
Coleman, CN; Palayoor, ST; Tofilon, PJ1
Ahmad, F; Cheruku, KK; Ghani, A; Pappas, P; Silver, MA; Silverman, PR; Zelinger, A1
Permi, J; Rosenberg, PH; Toivonen, J1
Coté, CJ; Dsida, R1
Wartell, RL1
Berger, MY; Bruijn, JK; Damen, L; Koes, BW; Passchier, J; Verhagen, AP1
Arora, S; Herbert, M; Wagner, JG1
Aranda, JV; Beharry, KD; Valencia, GB1
Burke, A; Cansino, C; Edelman, A; Jamshidi, R1
Aggarwal, V; Kabi, D; Singla, M1
Van Hulle Vincent, C; Wang, E; Wilkie, DJ2
Voepel-Lewis, T1
Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC1
Craig, KD; Schiavenato, M; von Baeyer, CL1
Braaten, KP; Fortin, J; Goldberg, AB; Hurwitz, S1
Hsu, JR; Noel, SP; Rathbone, CR; Rivera, JC; Wenke, JC1
Dimas, V; Ditthakasem, K; Fearon, JA; Herbert, MA1
Aravamuthan, BR; Mar, SS; Williams, KG1
Bosoy, D; Cohen, V; Fromm, C; Hossain, R; Jellinek-Cohen, SP; Likourezos, A; Marshall, J; Motov, S; Rockoff, B; Smith, A1
Dayno, J; Niebler, G1
Aranda, JV; Beharry, KD; Cai, CL; Lazzaro, D; Salomone, F; Valencia, AM; Valencia, GB1
Krawczeski, CD; Kwiatkowski, DM; Montez-Rath, ME; Sutherland, SM; Uber, AM1
Isenberg, DL; Wasserman, DD1
Baratta, JL; Dayan, AC; Pitchon, DN; Schwenk, ES; Viscusi, ER1
Balzer, S; Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Watts, K1
Gutmann, JL; Jinatongthai, P; Nagendrababu, V; Pulikkotil, SJ; Teerawattanapong, N; Veettil, SK1
Dwarica, DS; Nihira, MA; Pickett, SD; Quiroz, LH; Zhao, YD1
Aranda, N; Miranda, HF; Noriega, V; Poblete, P; Prieto, JC; Sierralta, F1
Allen, IE; Auerbach, A; Bongiovanni, T; Lancaster, E; Ledesma, Y; Steinman, MA; Whitaker, E; Wick, E1
Cortijo-Brown, A; Davitt, M; Feliciano, C; Friedman, BW; Irizarry, E; Restivo, A; Salama, M1
Kelley-Quon, LI; Kim, E; Kingston, P; Lascano, D; Ourshalimian, S; Russell, CJ1
Akira, R; Bassi, APF; Chiba, F; de Lima Neto, TJ; Faverani, LP; Grossi-Oliveira, GA; Han, M; Miloro, M; Momesso, GAC; Polo, TOB; Rios, BR; Silva, WPP; Sumida, DH1
Slawson, DC1
Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC1
Chiu, SH; Indermuhle, P; Mori, C; Zelko, M1
Abdelbaser, I; ALseoudy, MM; El-Emam, EM; Mageed, NA1
Elnaghy, AM; Elsaka, SE; Elshazli, AH1
Amaddeo, A; Barbi, E; Barbieri, F; Cozzi, G; De Nardi, L; Ghirardo, S; Maestro, A; Ronfani, L; Trevisan, M; Zanon, D1

Reviews

9 review(s) available for ibuprofen and ketorolac

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Peri-operative use of nonsteroidal anti-inflammatory drugs in children: analgesic efficacy and bleeding.
    Anaesthesia, 1997, Volume: 52, Issue:7

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Diclofenac; Drug Administration Schedule; Humans; Ibuprofen; Infant; Ketorolac; Pain, Postoperative; Postoperative Hemorrhage; Randomized Controlled Trials as Topic; Tolmetin

1997
Symptomatic treatment of migraine in children: a systematic review of medication trials.
    Pediatrics, 2005, Volume: 116, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Controlled Clinical Trials as Topic; Dihydroergotamine; Female; Humans; Ibuprofen; Ketorolac; Male; Migraine Disorders; Prochlorperazine; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Sulfonamides; Sumatriptan

2005
Myth: parenteral ketorolac provides more effective analgesia than oral ibuprofen.
    CJEM, 2007, Volume: 9, Issue:1

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Emergency Service, Hospital; Humans; Ibuprofen; Infusions, Parenteral; Ketorolac; Pain

2007
Nonsteroidal anti-inflammatory drugs (NSAIDs) in the newborn - which ones?
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22 Suppl 3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Hemorrhage; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Ketorolac

2009
Updates on Multimodal Analgesia for Orthopedic Surgery.
    Anesthesiology clinics, 2018, Volume: 36, Issue:3

    Topics: Acetaminophen; Amines; Analgesia; Celecoxib; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Ibuprofen; Ketamine; Ketorolac; Orthopedic Procedures; Pain, Postoperative

2018
Efficacy and Safety of Oral Premedication on Pain after Nonsurgical Root Canal Treatment: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.
    Journal of endodontics, 2019, Volume: 45, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Databases, Bibliographic; Female; Humans; Ibuprofen; Ketorolac; Male; Middle Aged; Pain, Postoperative; Piroxicam; Prednisolone; Premedication; Randomized Controlled Trials as Topic; Root Canal Therapy; Sulindac; Treatment Outcome; Young Adult

2019
Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period.
    Journal of the American College of Surgeons, 2021, Volume: 232, Issue:5

    Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Blood Transfusion; Diclofenac; Humans; Ibuprofen; Ketorolac; Pain, Postoperative; Pain, Procedural; Perioperative Period; Postoperative Hemorrhage; Surgical Procedures, Operative; Treatment Outcome

2021
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain

2022

Trials

16 trial(s) available for ibuprofen and ketorolac

ArticleYear
Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain.
    Annals of emergency medicine, 1995, Volume: 26, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Ionophores; Ketorolac; Middle Aged; Musculoskeletal Diseases; Pain; Prospective Studies; Tolmetin; Wounds and Injuries

1995
Recovery from outpatient laparoscopic tubal ligation is not improved by preoperative administration of ketorolac or ibuprofen.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:2

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Ketorolac; Laparoscopy; Pain, Postoperative; Premedication; Prospective Studies; Sterilization, Tubal; Time Factors; Tolmetin; Treatment Outcome

1994
Ketorolac versus acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus.
    Ophthalmology, 1994, Volume: 101, Issue:5

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ibuprofen; Injections, Intravenous; Ketorolac; Male; Middle Aged; Pain, Postoperative; Prospective Studies; Strabismus; Tolmetin

1994
Efficacy of nonsteroidal anti-inflammatory medications for prevention of atrial fibrillation following coronary artery bypass graft surgery.
    Preventive cardiology, 2004,Winter, Volume: 7, Issue:1

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Atrial Fibrillation; Coronary Artery Bypass; Female; Humans; Ibuprofen; Ketorolac; Male; Middle Aged; Postoperative Complications; Risk Factors

2004
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:4

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Codeine; Female; Fentanyl; Hernia, Inguinal; Humans; Ibuprofen; Ketorolac; Length of Stay; Male; Middle Aged; Nerve Block; Pain Measurement; Pain, Postoperative; Treatment Outcome

2004
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
    Obstetrics and gynecology, 2009, Volume: 114, Issue:6

    Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Ketorolac; Lidocaine; Pain; Pregnancy; Young Adult

2009
Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical tri
    Journal of endodontics, 2010, Volume: 36, Issue:3

    Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ibuprofen; Ketorolac; Lidocaine; Male; Mandibular Nerve; Nerve Block; Preanesthetic Medication; Premedication; Prospective Studies; Pulpitis; Root Canal Therapy; Statistics, Nonparametric; Young Adult

2010
Intramuscular ketorolac versus oral ibuprofen for pain relief in first-trimester surgical abortion: a randomized clinical trial.
    Contraception, 2014, Volume: 89, Issue:2

    Topics: Abortion, Induced; Administration, Oral; Adolescent; Adult; Analgesia; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Injections, Intramuscular; Ketorolac; Young Adult

2014
A Randomized Controlled Trial of Oral Versus Intravenous Administration of a Nonnarcotic Analgesia Protocol Following Pediatric Craniosynostosis Corrections on Nausea and Vomiting Rates.
    The Journal of craniofacial surgery, 2015, Volume: 26, Issue:6

    Topics: Acetaminophen; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Child, Preschool; Craniosynostoses; Female; Humans; Ibuprofen; Infant; Infusions, Intravenous; Ketorolac; Length of Stay; Male; Operative Time; Postoperative Nausea and Vomiting; Prospective Studies; Single-Blind Method

2015
Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation.
    Journal of endodontics, 2019, Volume: 45, Issue:2

    Topics: Acetaminophen; Acute Pain; Administration, Intranasal; Administration, Oral; Adult; Dental Pulp Necrosis; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ibuprofen; Ketorolac; Male; Periapical Periodontitis; Pulpitis; Severity of Illness Index; Treatment Outcome; Young Adult

2019
Comparing Ketorolac With Ibuprofen for Postoperative Pain: A Randomized Clinical Trial.
    Female pelvic medicine & reconstructive surgery, 2020, Volume: 26, Issue:4

    Topics: Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Ketorolac; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Prospective Studies

2020
A randomized controlled trial of ibuprofen versus ketorolac versus diclofenac for acute, nonradicular low back pain.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2021, Volume: 28, Issue:11

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibuprofen; Ketorolac; Low Back Pain

2021
A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions.
    Scientific reports, 2021, 12-27, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Drug Therapy, Combination; Etodolac; Female; Glucocorticoids; Humans; Ibuprofen; Ketorolac; Male; Molar, Third; Phenylpropionates; Prospective Studies; Tooth Extraction; Young Adult

2021
Comparison of intravenous ibuprofen versus ketorolac for postoperative analgesia in children undergoing lower abdominal surgery: A randomized, controlled, non-inferiority study.
    Revista espanola de anestesiologia y reanimacion, 2022, Volume: 69, Issue:8

    Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Child; Double-Blind Method; Humans; Ibuprofen; Ketorolac; Morphine; Pain, Postoperative; Tolmetin

2022
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketorolac; Lidocaine; Mandibular Nerve; Meloxicam; Nerve Block; Pain; Premedication; Prospective Studies; Pulpitis

2023
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
    European journal of pediatrics, 2023, Volume: 182, Issue:2

    Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double-Blind Method; Humans; Ibuprofen; Ketorolac

2023

Other Studies

51 other study(ies) available for ibuprofen and ketorolac

ArticleYear
Antinociceptive (aminoalkyl)indoles.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: Analgesia; Analgesics; Animals; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Indoles; Magnetic Resonance Spectroscopy; Male; Methylation; Mice; Molecular Conformation; Molecular Structure; Muscle Contraction; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Vas Deferens

1991
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
    Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Characterization of the drug binding specificity of rat liver fatty acid binding protein.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Anilino Naphthalenesulfonates; Animals; Fatty Acid-Binding Proteins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Fluorescence; Substrate Specificity

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.
    Journal of medicinal chemistry, 2011, Dec-22, Volume: 54, Issue:24

    Topics: Animals; Binding, Competitive; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Female; Ibuprofen; Ketorolac; Magnetic Resonance Spectroscopy; Male; Sheep

2011
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship

2012
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.
    ACS chemical biology, 2014, Nov-21, Volume: 9, Issue:11

    Topics: Fatty Acid-Binding Proteins; Fluorescent Dyes; Humans; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Spectrometry, Fluorescence

2014
Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.
    Cell chemical biology, 2017, Mar-16, Volume: 24, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Caspase Inhibitors; Caspases; Caspases, Initiator; Cell Line; Cell Survival; High-Throughput Screening Assays; Humans; Ibuprofen; Inhibitory Concentration 50; Ketorolac; Naproxen; Small Molecule Libraries; Substrate Specificity

2017
Comparative effects of four prostaglandin synthesis inhibitors on the obstructed kidney in the dog.
    The Journal of urology, 1986, Volume: 135, Issue:5

    Topics: Animals; Blood Pressure; Dogs; Female; Ibuprofen; Indomethacin; Ketorolac; Kidney Pelvis; Naproxen; Pressure; Prostaglandin Antagonists; Tolmetin; Ureteral Obstruction

1986
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:3

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Emergency Service, Hospital; Female; Hospitals, Teaching; Hospitals, Urban; Humans; Ibuprofen; Injections, Intramuscular; Ketorolac; Male; Pain; Pain Measurement; Retrospective Studies; Tolmetin

1994
Ketorolac versus ibuprofen: a simple cost-efficacy comparison for dental use.
    Journal (Canadian Dental Association), 1994, Volume: 60, Issue:1

    Topics: Analgesics; Cost-Benefit Analysis; Humans; Ibuprofen; Ketorolac; Pain, Postoperative; Tolmetin; Tooth Extraction; Toothache

1994
Anesthesiology.
    The New England journal of medicine, 1998, Mar-05, Volume: 338, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Pain, Postoperative; Piroxicam; Tolmetin

1998
If you have no destination, any road will do.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1998, Volume: 5, Issue:2

    Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Musculoskeletal System; Pain; Research Design; Tolmetin

1998
Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.
    Pain, 1998, Volume: 78, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclooxygenase Inhibitors; Freund's Adjuvant; Hyperalgesia; Ibuprofen; In Vitro Techniques; Injections, Spinal; Ketorolac; Male; Myelitis; Neuropeptides; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tolmetin

1998
Spinal action of ketorolac, S(+)- and R(-)-ibuprofen on non-noxious activation of the catechol oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia.
    Anesthesiology, 1999, Volume: 90, Issue:1

    Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Catechols; Electrophysiology; Glycine Agents; Ibuprofen; Injections, Spinal; Ketorolac; Locus Coeruleus; Oxidation-Reduction; Pain; Physical Stimulation; Rats; Spinal Cord; Strychnine; Tolmetin

1999
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
    Archives of biochemistry and biophysics, 1999, Feb-15, Volume: 362, Issue:2

    Topics: Aging; Animals; Arachidonic Acids; Brain; Cell Extracts; Cell Survival; Dose-Response Relationship, Drug; Endocannabinoids; Flurbiprofen; Glioma; Hydrolysis; Ibuprofen; Inhibitory Concentration 50; Ketorolac; Kinetics; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors; Tolmetin; Tumor Cells, Cultured

1999
Stereoselective and substrate-dependent inhibition of hepatic mitochondria beta-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac.
    Biochemical pharmacology, 1999, Apr-01, Volume: 57, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coenzyme A; Flurbiprofen; Ibuprofen; Ketorolac; Lipid Metabolism; Male; Mitochondria, Liver; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Palmitic Acid; Rats; Rats, Wistar; Stereoisomerism; Tolmetin

1999
Comparative effects of cyclo-oxygenase and nitric oxide synthase inhibition on the development and reversal of spinal opioid tolerance.
    British journal of pharmacology, 1999, Volume: 127, Issue:3

    Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Tolerance; Enzyme Inhibitors; Ibuprofen; Injections, Intraperitoneal; Injections, Spinal; Ketorolac; Male; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Rats; Rats, Sprague-Dawley; Spinal Cord; Tolmetin

1999
Isoprostanes induce plasma extravasation in rat skin.
    Prostaglandins & other lipid mediators, 2000, Volume: 62, Issue:4

    Topics: Animals; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; F2-Isoprostanes; Ibuprofen; Inflammation; Injections, Subcutaneous; Isoprostanes; Ketorolac; Male; Rats

2000
Prohemorrhagic potential of dipyrone, ibuprofen, ketorolac, and aspirin: mechanisms associated with blood flow and erythrocyte deformability.
    Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aspirin; Dipyrone; Endothelium, Vascular; Erythrocyte Deformability; Hemorrhagic Disorders; Humans; Ibuprofen; Ketorolac; Platelet Aggregation; Rabbits; Regional Blood Flow

2001
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
    Medicine and health, Rhode Island, 2001, Volume: 84, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors

2001
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-01, Volume: 9, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ibuprofen; Isoenzymes; Ketorolac; Male; Membrane Proteins; Monosaccharide Transport Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Sulfonamides; Time Factors; Trans-Activators; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A

2003
Nonsteroidal antiinflammatory drugs and hemorrhage following tonsillectomy: do we have the data?
    Anesthesiology, 2004, Volume: 100, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Postoperative Hemorrhage; Tonsillectomy

2004
Parecoxib versus ibuprofen.
    Journal of the American Dental Association (1939), 2005, Volume: 136, Issue:3

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Injections, Intramuscular; Isoxazoles; Ketorolac; Pain, Postoperative; Tooth Extraction

2005
Pediatric nurses' beliefs and pain management practices: an intervention pilot.
    Western journal of nursing research, 2011, Volume: 33, Issue:6

    Topics: Analgesics; Feasibility Studies; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Pilot Projects; Surveys and Questionnaires; Workforce

2011
Bridging the gap between pain assessment and treatment: time for a new theoretical approach?
    Western journal of nursing research, 2011, Volume: 33, Issue:6

    Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce

2011
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
    Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts

2012
Self-report is a primary source of information about pain, but it is not infallible: a comment on "response to Voepel-Lewis's letter to the editor, 'bridging the gap between pain assessment and treatment: time for a new theoretical approach?'".
    Western journal of nursing research, 2013, Volume: 35, Issue:3

    Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce

2013
Response to Schiavenato, von Baeyer, and Craig's letter to the editor.
    Western journal of nursing research, 2013, Volume: 35, Issue:3

    Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce

2013
Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for Heterotopic Ossification Prevention.
    Clinical and translational science, 2015, Volume: 8, Issue:5

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA Replication; Female; Humans; Ibuprofen; Indomethacin; Ketorolac; Male; Ossification, Heterotopic; Osteoblasts; Rats; Skin; Time Factors; Wound Healing; Wounds and Injuries

2015
Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine.
    Pediatric emergency care, 2017, Volume: 33, Issue:9

    Topics: Administration, Intranasal; Administration, Intravenous; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Emergency Service, Hospital; Emergency Treatment; Female; Humans; Ibuprofen; Ketorolac; Male; Migraine Disorders; Pain; Pain Measurement; Patient Discharge; Retrospective Studies; Treatment Outcome

2017
Development of an opioid reduction protocol in an emergency department.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015, Dec-01, Volume: 72, Issue:23

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Chronic Pain; Emergency Service, Hospital; Humans; Ibuprofen; Ketorolac; Pain Measurement; Patient Satisfaction; Severity of Illness Index; Time Factors

2015
Effect size comparison of ketorolac nasal spray and commonly prescribed oral combination opioids for pain relief after third molar extraction surgery.
    Postgraduate medicine, 2016, Volume: 128, Issue:1

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female; Humans; Hydrocodone; Ibuprofen; Ketorolac; Male; Molar, Third; Nasal Sprays; Oxycodone; Pain Measurement; Pain, Postoperative; Randomized Controlled Trials as Topic; Tooth Extraction; Tramadol; Treatment Outcome; Young Adult

2016
Human retinal endothelial cells and astrocytes cultured on 3-D scaffolds for ocular drug discovery and development.
    Prostaglandins & other lipid mediators, 2018, Volume: 134

    Topics: Astrocytes; Biomimetics; Coculture Techniques; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Drug Discovery; Drug Interactions; Endothelial Cells; Humans; Ibuprofen; Ketorolac; Retina; Thromboxane B2

2018
Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.
    Pediatric nephrology (Berlin, Germany), 2018, Volume: 33, Issue:11

    Topics: Acute Kidney Injury; Adolescent; Aspirin; Cardiac Surgical Procedures; Child; Child, Preschool; Critical Illness; Enalapril; Female; Heart Defects, Congenital; Humans; Ibuprofen; Infant; Ketorolac; Male; Piperacillin, Tazobactam Drug Combination; Postoperative Complications; Retrospective Studies; Vancomycin

2018
A Case of Acute Traumatic Lumbar Paraspinal Compartment Syndrome.
    The Journal of emergency medicine, 2018, Volume: 55, Issue:4

    Topics: Accidental Falls; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Compartment Syndromes; Female; Humans; Ibuprofen; Ketorolac; Lumbosacral Region; Morphine; Obesity, Morbid; Paraspinal Muscles; Tomography, X-Ray Computed

2018
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
    Drug research, 2019, Volume: 69, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ibuprofen; Ketoprofen; Ketorolac; Mice; Nitric Oxide; Pain; Pain Measurement

2019
Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis.
    Journal of pediatric surgery, 2022, Volume: 57, Issue:8

    Topics: Appendectomy; Appendicitis; Child; Hemorrhage; Humans; Ibuprofen; Ketorolac; Retrospective Studies

2022
Ibuprofen, Ketorolac, and Diclofenac Are Equivalent for the Treatment of Acute, Nonradicular Low Back Pain.
    American family physician, 2022, 05-01, Volume: 105, Issue:5

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibuprofen; Ketorolac; Low Back Pain

2022
Use of Scheduled Nonopioid Analgesia to Decrease Inpatient Opioid Consumption After Scheduled Cesarean Birth.
    Nursing for women's health, 2022, Volume: 26, Issue:5

    Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Humans; Ibuprofen; Inpatients; Ketorolac; Oxycodone; Pain, Postoperative; Pregnancy

2022