ibuprofen and flurbiprofen

ibuprofen has been researched along with flurbiprofen in 183 studies

Research

Studies (183)

TimeframeStudies, this research(%)All Research%
pre-199041 (22.40)18.7374
1990's36 (19.67)18.2507
2000's45 (24.59)29.6817
2010's49 (26.78)24.3611
2020's12 (6.56)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Cihlar, T; Ho, ES; Mulato, AS1
Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N1
Carey, KN; Casillas, EG; Gupta, K; Kaub, CJ; Loll, PJ; Selinsky, BS1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Chang, TK; Ensom, MH; Kiang, TK1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A1
Caron, G; Ermondi, G1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Amir, M; Javed, SA; Kumar, H1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Chuang, S; Horne, J; Porter, CJ; Scanlon, MJ; Velkov, T1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Kumar, M; Sinha, VR; Thareja, S1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bellman, K; Knegtel, RM; Settimo, L1
Headey, SJ; Hughes, ML; Laguerre, A; Mohanty, B; Patil, R; Porter, CJ; Scanlon, MJ; Wielens, J; Williams, ML1
Brewster, C; Deering-Rice, CE; Reilly, CA; Rose, TM1
Aytaç, PS; Çetin-Atalay, R; Durmaz, I; Houston, DR; Tozkoparan, B1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Lund, C; Lynagh, T; Pless, SA; Romero-Rojo, JL1
Basu, P; Elias, R; Fridman, M1
Anderson, JA; Buchanan, WW; Lee, P; Miller, J; Webb, J1
Nozu, K1
Briney, WG; Giansiracusa, J; Mena, HR; Ward, JR; Wolski, KP; Zuckner, J1
Alphen, GW; Wilhelm, PB1
Ehrlich, GE; Giansiracusa, J; Gray, J; Mena, HR; Ward, J1
Birkett, DJ; Sudlow, G; Wade, DN1
Fitzpatrick, FA; Wynalda, MA1
Ghosh, P; Horsburgh, BA; McKenzie, LS; Taylor, TK1
Lands, WE; Rome, LH1
Masumoto, S; Okumura, M; Takase, K1
Hall, SD; Hassanzadeh-Khayyat, M; Knadler, MP; Mayer, PR1
Baillie, TA; Knights, KM; Talbot, UM1
Bundgaard, H; Mørk, N1
Brune, K; Geisslinger, G; Menzel-Soglowek, S; Mollenhauer, J1
Adams, SS1
Day, RO; Geisslinger, G; Hall, I; Williams, KM; Zhao, B1
Goldhaber, P; Hall, CM; Howell, TH; Jeffcoat, MK; Johnson, HG; Odle, BM; Offenbacher, S; Smith, MA; Williams, RC1
Fleury, AA; Hammond, BF; Hersh, EV1
Kaufhold, J; McCabe, K; Wilkowski, M1
Fritz, ME; Green, MD; Mayambala, CS; Odle, BM; Offenbacher, S; Sena, FJ; Smith, MA; van Dyke, TE; Yeh, KC1
Mayer, JM1
Coates, J; Friedman, H; Jamali, F; Russell, AS; Skeith, KJ1
Day, RO; Graham, GG; Knihinicki, RD; Williams, KM1
Boney, RS; Goldenberg, MM; Rosenbaum, JT; Tilden, ME1
Butler, DP; Dionne, RA; Hargreaves, KM; Troullos, ES1
Hall, SD; Knadler, MP1
Tempowski, JH1
Day, RO; Knihinicki, RD; Williams, KM1
Hargreaves, KM; Jackson, DL; Moore, PA1
Blessington, B; Crabb, N; Karkee, S; Northage, A1
Bartolucci, C; Maître, JM; Mayer, JM; Testa, B1
Akhter, SA; Barry, BW1
Karmali, RA; Marsh, J2
Karmali, RA1
Denlinger, RH; Elliott, GA; Purmalis, A; VanderMeer, DA1
Crittenden, N; Fitzpatrick, F; McGee, J; McGuire, J1
Giroud, JP; Hakim, J; Perianin, A1
Castell, JV; Gómez-Lechón, MJ; Larrauri, A1
Cox, SR; Gumbleton, TJ; Smith, RB; VanderLugt, JT1
Crossley, MJ; Hunneyball, IM; Spowage, M1
Dawood, MY; Jarrett, JC1
Askholt, J; Nielsen-Kudsk, F1
diZerega, GS; Nakamura, RM; Shimanuki, T1
Buchanan, WW; Kassam, YB1
Rampton, DS; Sladen, GE1
Bauer, FC; Lindholm, TS; Nilsson, OS; Törnkvist, H1
Ito, T; Miyamoto, S; Murakami, T; Sato, M; Sayama, T; Sudo, M; Suzuki, A; Tamura, M; Tazawa, M; Yoshida, M1
Giroud, JP; Hakim, J; Perianin, A; Roch-Arveiller, M1
Cima, L; Fabbri, G; Giusti, P; Rampa, A; Valenti, P1
Baxi, AJ; Gupta, KC; Kulkarni, VN; Pispati, PK; Sheth, UK; Valame, SP1
Darsee, JR; Kloner, RA1
Beaubien, LJ; Rahn, PD; Sears, DJ; Snider, BG1
Araki, H; Lefer, AM1
Carrow, BA; Lefer, AM; Smith, EF1
Galasko, CS; Lacey, E; Rushton, S; Samuel, AW1
Chemtob, S; Hanna, N; Lachapelle, P; Orquin, J; Roy, MS; Varma, DR1
Dang, H; Flescher, E; Fossum, D; Ledbetter, JA; Ogawa, N; Talal, N; Vela-Roch, N1
Lafontaine, N; Rochette, L; Rozenfarb, E; Tousignant, J1
Brune, K; Geisslinger, G; Menzel-Soglowek, S1
Beck, WS; Brune, K; Geisslinger, G; Menzel, S1
Howell, TH; Williams, RC1
Eacho, PI; Foxworthy, PS; Perry, DN1
Bhattacharyya, DK; Garavito, M; Lecomte, M; Rieke, CJ; Smith, WL1
Etter, JC; Mayer, JM; Roy-de Vos, M; Testa, B1
Kelkar, MG; Nayak, PJ; Pargal, A1
Davies, NM; Jamali, F; Russell, AS; Wright, MR1
Derendorf, H; Grundy, BL; Suri, A1
Jamali, F; Mehvar, R1
Gupta, M; Majumdar, DK1
Lau, HY; Stenton, GR1
el-Bary, AA; el-Nabarawi, MA; Mohamed, MI1
Fowler, CJ; Janson, U; Johnson, RM; Norström, K; Stenström, A; Tiger, G; Wahlström, G1
Browne, GS; Day, RO; Ellis, BA; Nelson, C; Nguyen, T; Williams, KM1
Bhushan, R; Thiongo, GT1
Allegretti, M; Bertini, R; Biordi, L; Caselli, G; Martinotti, S; Marullo, A; Mascagni, P; Sabbatini, V1
Belder, D; Husmann, H; Warnke, J1
Gupta, K; Loll, PJ; Selinsky, BS; Sharkey, CT1
Connor, KE; Coppola, D; DiCarlo, G; Gordon, MN; Jantzen, PT; Morgan, D; Rojiani, AM; Wallace, JL; Wenk, GL1
Austin, J; Hage, DS; Kim, HS1
Egyed, A; Fedorocko, P; Hofer, M; Hoferová, Z; Hofmanová, J; Kozubík, A; Minksová, K; Soucek, K; Znojil, V1
Beech, W; Chu, T; Cole, GM; Morihara, T; Ubeda, O1
Abushoffa, AM; Crommen, J; Fillet, M; Hubert, P; Servais, AC1
Fowler, CJ; Holt, S1
Bateman, SD; Erck, R; Li, T; Morris, KR; Wang, JJ1
Goto, J; Kim, J; Kim, JH; Kim, KR; La, S1
Bateman, SD; Guillot, MA; Morris, KR; Wang, JJ1
Kobayashi, D; Kogo, T; Morimoto, Y; Numajiri, S; Shimamura, T; Tairabune, T; Ueda, H1
Bagheri, H; Lacroix, I; Lapeyre-Mestre, M; Montastruc, JL; Pathak, A1
Klegeris, A; Maguire, J; McGeer, PL1
Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A1
Maftouh, M; Mangelings, D; Massart, DL; Matthijs, N; Tanret, I; Vander Heyden, Y1
Karaman, AI; Polat, O1
Praticò, D; Townsend, KP1
Hamoudová, R; Pospísilová, M1
Mandula, H; Parepally, JM; Smith, QR1
Hornung, S; Krill, SL; Vippagunta, SR; Wang, Z1
El-Fayomi, HM; El-Sadek, ME; Lashine, el-SM; Metwally, KA; Yaseen, SH1
Djakiew, D; Khwaja, F; Quann, EJ; Zavitz, KH1
Ji, H; Peng, SX; Zhang, YH1
Djakiew, D; Khwaja, F; Quann, EJ1
Han, JA; Kim, SR; Lee, ME; Park, JH; Park, JS; Park, SC1
Andrews, PM; Hoe, HS; Rebeck, GW; Zhao, X1
Cenacchi, V; Facchinetti, F; Hutter-Paier, B; Imbimbo, BP; Lanzillotta, A; Pizzi, M; Villetti, G; Volta, R; Windisch, M1
Angeletti, M; Censi, R; Di Martino, P; Gashi, Z; Gobetto, R; Malaj, L; Masic, A; Mozzicafreddo, M1
Baltrons, MA; Carriba, P; Galea, E; García, A; Lichtenstein, MP; Peterson, JR; Wojciak-Stothard, B1
De la Cruz, JP; Gonzalez-Correa, JA; Jebrouni, N; Lopez-Villodres, JA; Reyes, JJ; Ruiz-Moreno, MI1
Djakiew, D; Wynne, S1
Baiguera, C; Benarese, M; Branca, C; Hutter-Paier, B; Imbimbo, BP; Lanzillotta, A; Pizzi, M; Sarnico, I; Spano, P; Windisch, M1
De La Cruz, JP; González-Correa, JA; Guerrero, A; López-Villodres, JA; Muñoz-Marin, J; Reyes, JJ1
Aoki, Y; Honjo, H; Iwamoto, K; Uwai, Y1
Chen, M; Chow, AH; Chow, SF; Shi, L; Sun, CC1
Aboul-Enein, HY; Ali, I; Hussain, I; Saleem, K1
Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y1
Holm, R; Jørgensen, EB; Larsen, KL; Lumholdt, LR1
Bouchet, LM; de la Guardia, M; Delgado-Pérez, T; Galian, RE; Pérez-Prieto, J1
Arimori, K; Ogata, K; Osaki, T; Ozaki, M; Setoguchi, N; Takamura, N; Tokunaga, J1
Dubský, P; Gaš, B; Müllerová, L1
Fowler, CJ; Karlsson, J1
Gaš, B; Riesová, M; Svobodová, J; Tošner, Z; Ušelová, K; Zusková, I1
Dimoglo, A; Erçetin, T; Esiringu, İ; Gülcan, HO; Öz, D; Şahin, MF; Şahin, Y; Ünlü, S1
Gjelstad, A; Pedersen-Bjergaard, S; Roldán-Pijuán, M1
Chen, Z; Fan, H; Huang, X; Luo, A; Wan, Q; Wu, X; Zang, L1
Funakami, Y; Kato, Y; Nagai, N; Tanino, T1
Jiang, CY; Li, FL; Li, X; Li, Y; Lu, Y; Zhuo, HW1
Catalanotti, B; Congiu, C; Deplano, A; Fowler, CJ; Karlsson, J; Luque, FJ; Morgillo, CM; Novellino, E; Onnis, V; Pedone, E; Smaldone, G; Svensson, M1
Gu, J; Guo, T; Guo, Z; Li, H; Shao, Q; Sun, L; Wang, C; Wu, L; Yin, X; York, P; Zhang, J1
Camacho-Muñoz, D; Kasprzyk-Hordern, B; Thomas, KV1
Bellucci, A; Benarese, M; Branca, C; Faggi, L; Imbimbo, BP; Lanzillotta, A; Mota, M; Parrella, E; Pizzi, M; Porrini, V; Sarnico, I; Spano, P1
Canotilho, J; Castro, RAE; Eusébio, MES; Machado, SMT; Maria, TMR1
Iwaki, M; Kawase, A; Kobayashi, Y; Ogiso, T; Shimada, H; Tanahashi, S1
Akpınar, M; Coşkun, BU; Erol, ZN; Kaya, KS; Türk, B; Ünsal, Ö1
Ask, KS; Gjelstad, A; Pedersen-Bjergaard, S; Øiestad, EL1
Abbas, S; Abbas, SM; Ali, S; Hameed, S; Iqbal, J; Munawar, KS; Rahman, SU; Shaheen, F; Tahir, MN; Zaib, S1
Ma, R; Qu, H; Wang, B; Wang, F; Yu, G; Yu, Y1
Alshana, U; Hassan, M1
Carrasco-Correa, EJ; Giesbers, M; Herrero-Martínez, JM; Simó-Alfonso, EF1
Barlow, DJ; Jackson, PJM; Pysz, I; Rahman, KM; Thurston, DE1
Glatz, Z; Michalcová, L; Nevídalová, H1
Dai, X; Ding, CF; Fang, X; Gu, L; Jiang, Y; Wu, F; Xu, F; Yang, S; Yu, S1
Eichhorn, T; Hey-Hawkins, E; Kaluđerović, GN; Morgan, I; Predarska, I; Saoud, M1
Chaturvedi, K; Dave, RH; Morris, KR; Shah, HS1
Bojkova, D; Charlesworth, B; Ciesek, S; Cinatl, J; de Bruin, N; Gribbon, P; Kannt, A; Laughey, WF; Lodhi, I; Pennick, G; Reus, P; Schiffmann, S; Schneider, AK; Sinclair, S; Talmon, S1
Bădulescu, M; Stefan-van Staden, RI; Ţuchiu, BM; van Staden, JF1
Du, G; Fang, Z; Gong, N; Lu, Y; Xing, C; Xing, W; Yu, H; Zhang, B1
Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC1
Habara, M; Haraguchi, T; Ikezaki, H; Kawasaki, I; Kojima, H; Ohkawa, K; Ozeki, M; Uchida, T; Uno, R; Yoshida, M1
Abdul Qadir, M; Ahmad, S; Ahmed, M; Ali, I; Imran, M; Muddassar, M; Wani, TA; Yousaf, N; Zargar, S1

Reviews

11 review(s) available for ibuprofen and flurbiprofen

ArticleYear
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The propionic acids: a personal perspective.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:4

    Topics: Analgesia; Animals; Arthritis, Rheumatoid; Aspirin; Drug Therapy; Flurbiprofen; Humans; Ibuprofen; Phenylacetates; Phenylpropionates; Propionates

1992
Stereoselective metabolism of anti-inflammatory 2-arylpropionates.
    Acta pharmaceutica Nordica, 1990, Volume: 2, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Naproxen; Stereoisomerism; Suprofen

1990
Preoperative nonsteroidal anti-inflammatory medication for the prevention of postoperative dental pain.
    Journal of the American Dental Association (1939), 1989, Volume: 119, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Humans; Ibuprofen; Mouth; Pain, Postoperative; Premedication; Tooth Extraction

1989
The propionic acids. Gastrointestinal toxicity in various species.
    Toxicologic pathology, 1988, Volume: 16, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Digestive System; Dogs; Fenoprofen; Flurbiprofen; Haplorhini; Ibuprofen; Naproxen; Propionates; Rats; Species Specificity

1988
Nonsteroidal antiinflammatory drugs as inhibitors of periodontal disease progression.
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 1993, Volume: 4, Issue:2

    Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Inflammation; Periodontal Diseases; Prostaglandin Antagonists; Prostaglandins

1993
Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods.
    Clinical pharmacokinetics, 1997, Volume: 33, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Area Under Curve; Computer Simulation; Disopyramide; Doxepin; Drug Interactions; Flurbiprofen; Food-Drug Interactions; Guidelines as Topic; Hydroxychloroquine; Ibuprofen; Nadolol; Nortriptyline; Propafenone; Stereoisomerism; Therapeutic Equivalency; Verapamil

1997
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:12

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Inflammation; Models, Biological; Models, Chemical; Models, Genetic; NF-kappa B; Peptides; Peroxisome Proliferator-Activated Receptors; PPAR gamma; Prostaglandin-Endoperoxide Synthases

2005
[A novel class of anti-inflammatory and analgesic drugs--NO-donating NSAIDs].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:4

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Cyclooxygenase Inhibitors; Flurbiprofen; Gastrointestinal Diseases; Humans; Ibuprofen; Naproxen; Nitrates; Nitric Oxide Donors

2007
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain

2022

Trials

10 trial(s) available for ibuprofen and flurbiprofen

ArticleYear
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 3, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Mefenamic Acid; Pain; Phenylacetates; Placebos; Prednisone; Salicylates

1976
Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen.
    Journal of clinical pharmacology, 1977, Volume: 17, Issue:1

    Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Patient Compliance; Phenylpropionates; Propionates

1977
Response of osteoarthritis to ibuprofen or flurbiprofen.
    The Journal of international medical research, 1976, Volume: 4, Issue:3

    Topics: Aged; Clinical Trials as Topic; Drug Evaluation; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; Phenylpropionates; Propionates

1976
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1990, Volume: 48, Issue:9

    Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibuprofen; Inflammation; Male; Methylprednisolone; Molar, Third; Pain, Postoperative; Tooth Extraction; Tooth, Impacted; Trismus; Vertical Dimension

1990
[A double-blind clinical evaluation of flurbiprofen on acute upper respiratory tract inflammation--comparative study with ibuprofen].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1984, Volume: 58, Issue:12

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Propionates; Respiratory Tract Infections

1984
The effect of food on the bioavailability of ibuprofen and flurbiprofen from sustained release formulations.
    Biopharmaceutics & drug disposition, 1996, Volume: 17, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Diet, Vegetarian; Flurbiprofen; Food-Drug Interactions; Humans; Ibuprofen; Male

1996
Pharmacokinetics and pharmacodynamics of enantiomers of ibuprofen and flurbiprofen after oral administration.
    International journal of clinical pharmacology and therapeutics, 1997, Volume: 35, Issue:1

    Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Evoked Potentials; Flurbiprofen; Humans; Ibuprofen; Pain Measurement; Placebos; Stereoisomerism

1997
Pain control during fixed orthodontic appliance therapy.
    The Angle orthodontist, 2005, Volume: 75, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Facial Pain; Female; Flurbiprofen; Humans; Ibuprofen; Male; Naproxen; Orthodontic Appliances; Orthodontics, Corrective; Pain Measurement; Prospective Studies; Surveys and Questionnaires

2005
Albumin-binding of diclofenac and the effect of a site II inhibitor in the aqueous humor of cataract patients with the instillation of diclofenac.
    Biopharmaceutics & drug disposition, 2014, Volume: 35, Issue:4

    Topics: Administration, Ophthalmic; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Binding Sites; Cataract; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Serum Albumin

2014
The effect of flurbiprofen oral spray and ibuprofen vs ibuprofen alone on postoperative tonsillectomy pain: An open, randomised, controlled trial.
    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2018, Volume: 43, Issue:3

    Topics: Adolescent; Adult; Analgesics; Drug Therapy, Combination; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Oral Sprays; Pain, Postoperative; Tonsillectomy; Young Adult

2018

Other Studies

162 other study(ies) available for ibuprofen and flurbiprofen

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
    Molecular pharmacology, 1999, Volume: 55, Issue:5

    Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis

1999
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1

    Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship

2000
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Aug-05, Volume: 100, Issue:16

    Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors

2003
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.
    Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Carboxylic Acids; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Flurbiprofen; Halogens; Ibuprofen; Isoenzymes; Kinetics; Propionates; Prostaglandin-Endoperoxide Synthases; Sheep; Structure-Activity Relationship

2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
    Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism

2005
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:10

    Topics: Acute Disease; Analgesics; Animals; Bacteria; Diphenylacetic Acids; Female; Fungi; Hepatocytes; Ibuprofen; Inflammation; Lipid Peroxidation; Male; Mice; Rats; Thiadiazoles; Triazoles; Ulcer

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Characterization of the drug binding specificity of rat liver fatty acid binding protein.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Anilino Naphthalenesulfonates; Animals; Fatty Acid-Binding Proteins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Fluorescence; Substrate Specificity

2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.
    ACS chemical biology, 2014, Nov-21, Volume: 9, Issue:11

    Topics: Fatty Acid-Binding Proteins; Fluorescent Dyes; Humans; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Spectrometry, Fluorescence

2014
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.
    Bioorganic & medicinal chemistry letters, 2014, Dec-15, Volume: 24, Issue:24

    Topics: Amidohydrolases; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Flurbiprofen; Humans; Serotonin; TRPV Cation Channels

2014
Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins.
    Bioorganic & medicinal chemistry, 2016, Feb-15, Volume: 24, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Line, Tumor; Cyclin D1; Cytoskeletal Proteins; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hepatocytes; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinase 5; MCF-7 Cells; Molecular Docking Simulation; Nuclear Proteins; Oxidative Stress; Protein Structure, Secondary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship; Signal Transduction; Thiadiazines; Triazoles

2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.
    Journal of medicinal chemistry, 2017, 10-12, Volume: 60, Issue:19

    Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Allosteric Regulation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chick Embryo; Ibuprofen; Models, Molecular; Protein Conformation; Rats; Structure-Activity Relationship; Xenopus laevis

2017
Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles.
    Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3

    Topics: Antifungal Agents; Candida; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 51; Ergosterol; Fluconazole; Microbial Sensitivity Tests; Stereoisomerism

2022
Flurbiprofen: highly potent inhibitor of prostaglandin synthesis.
    Biochimica et biophysica acta, 1978, Jun-23, Volume: 529, Issue:3

    Topics: Animals; Arachidonic Acids; Aspirin; Cattle; Cyclooxygenase Inhibitors; Flurbiprofen; Ibuprofen; Indomethacin; Male; Microsomes; Oxygen Consumption; Phenylbutazone; Propionates; Prostaglandins E; Seminal Vesicles

1978
Potentiation of PG effects on the intraocular muscles of the cat by inhibition of PG synthesis.
    Documenta ophthalmologica. Advances in ophthalmology, 1977, Feb-28, Volume: 42, Issue:2

    Topics: Animals; Cats; Ciliary Body; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Flurbiprofen; Ibuprofen; In Vitro Techniques; Indomethacin; Iris; Mixed Function Oxygenases; Muscle Contraction; Muscle, Smooth; Prostaglandins; Prostaglandins E; Prostaglandins F

1977
Further characterization of specific drug binding sites on human serum albumin.
    Molecular pharmacology, 1976, Volume: 12, Issue:6

    Topics: Binding Sites; Dialysis; Flurbiprofen; Humans; Ibuprofen; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Stearic Acids

1976
In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents.
    Prostaglandins, 1976, Volume: 12, Issue:6

    Topics: Acetaminophen; Acetonitriles; Administration, Oral; Animals; Anti-Inflammatory Agents; Brain; Duodenum; Female; Flurbiprofen; Gastric Mucosa; Ibuprofen; Indomethacin; Intestine, Small; Kidney; Liver; Lung; Prostaglandins E; Prostaglandins F; Radioimmunoassay; Rats; Time Factors

1976
Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage.
    Annals of the rheumatic diseases, 1976, Volume: 35, Issue:6

    Topics: Aged; Aging; Anti-Inflammatory Agents; Cartilage, Articular; Depression, Chemical; Flurbiprofen; Glycosaminoglycans; Humans; Hydrocortisone; Ibuprofen; In Vitro Techniques; Indomethacin; Middle Aged; Sodium Salicylate

1976
Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.
    Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:12

    Topics: Anti-Inflammatory Agents; Aspirin; Fatty Acids; Flurbiprofen; Ibuprofen; Indomethacin; Kinetics; Meclofenamic Acid; Mefenamic Acid; Oxygen Consumption; Oxygenases; Prostaglandins; Structure-Activity Relationship

1975
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Guinea Pigs; Ibuprofen; Male; Mice; Propionates; Rats; Serum Albumin

1975
Pulmonary inversion of 2-arylpropionic acids: influence of protein binding.
    Chirality, 1992, Volume: 4, Issue:6

    Topics: Animals; Chromatography, High Pressure Liquid; Fenoprofen; Flurbiprofen; Ibuprofen; In Vitro Techniques; Lung; Male; Molecular Conformation; Protein Binding; Rabbits; Serum Albumin, Bovine; Stereoisomerism

1992
Evidence of multiple forms of rat liver microsomal coenzyme A ligase catalysing the formation of 2-arylpropionyl-coenzyme A thioesters.
    Biochemical pharmacology, 1992, Dec-15, Volume: 44, Issue:12

    Topics: Animals; Coenzyme A Ligases; Esters; Flurbiprofen; Ibuprofen; Isoenzymes; Microsomes, Liver; Rats; Stereoisomerism; Sulfhydryl Compounds; Thiolester Hydrolases

1992
Stereoselective enzymatic hydrolysis of various ester prodrugs of ibuprofen and flurbiprofen in human plasma.
    Pharmaceutical research, 1992, Volume: 9, Issue:4

    Topics: Esters; Flurbiprofen; Humans; Hydrolysis; Ibuprofen; Prodrugs

1992
Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism.
    Biochemical pharmacology, 1992, Apr-01, Volume: 43, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Rats; Species Specificity; Stereoisomerism; Tumor Cells, Cultured

1992
The effect of the enantiomers of ibuprofen and flurbiprofen on the beta-oxidation of palmitate in the rat.
    Chirality, 1992, Volume: 4, Issue:3

    Topics: Animals; Carbon Dioxide; Flurbiprofen; Ibuprofen; Male; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Rats; Rats, Inbred Strains; Stereoisomerism

1992
Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss.
    Journal of periodontal research, 1992, Volume: 27, Issue:3

    Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Flurbiprofen; Gingival Crevicular Fluid; Ibuprofen; Naproxen; Prostaglandins F; Thromboxane B2

1992
Antimicrobial activity of flurbiprofen and ibuprofen in vitro against six common periodontal pathogens.
    The Journal of clinical dentistry, 1991, Volume: 3, Issue:1

    Topics: Aggregatibacter actinomycetemcomitans; Bacteroides; Eikenella corrodens; Flurbiprofen; Fusobacterium nucleatum; Gram-Negative Bacteria; Ibuprofen; Periodontal Diseases; Wolinella

1991
Flurbiprofen-associated acute tubulointerstitial nephritis.
    American journal of nephrology, 1991, Volume: 11, Issue:2

    Topics: Adult; Biopsy; Flurbiprofen; Humans; Ibuprofen; Kidney; Male; Nephritis, Interstitial; Pain

1991
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents.
    Agents and actions, 1990, Volume: 29, Issue:3-4

    Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Eicosapentaenoic Acid; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Meclofenamic Acid; Naproxen; Periodontitis; Periodontium; Vitamin E

1990
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis.
    The Journal of rheumatology, 1990, Volume: 17, Issue:8

    Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Flurbiprofen; Humans; Ibuprofen; Injections, Intramuscular; Male; Methotrexate; Middle Aged

1990
Stereoselective disposition of ibuprofen and flurbiprofen in rats.
    Chirality, 1990, Volume: 2, Issue:3

    Topics: Animals; Flurbiprofen; Ibuprofen; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Stereoisomerism

1990
The effects of topical S(+)-ibuprofen on interleukin-1 induced ocular inflammation in a rabbit model.
    Journal of ocular pharmacology, 1990,Summer, Volume: 6, Issue:2

    Topics: Administration, Topical; Animals; Aqueous Humor; Capillary Permeability; Cell Count; Disease Models, Animal; Eye Proteins; Female; Flurbiprofen; Ibuprofen; Interleukin-1; Male; Prednisolone; Rabbits; Uveitis

1990
Stereoselective arylpropionyl-CoA thioester formation in vitro.
    Chirality, 1990, Volume: 2, Issue:2

    Topics: Acyl Coenzyme A; Animals; Coenzyme A; Coenzyme A Ligases; Fenoprofen; Flurbiprofen; Ibuprofen; In Vitro Techniques; Male; Protein Binding; Pseudomonas; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Serum Albumin, Bovine; Stereoisomerism; Subcellular Fractions; Substrate Specificity

1990
Ibuprofen poisoning in dogs.
    The Veterinary record, 1989, Nov-11, Volume: 125, Issue:20

    Topics: Animals; Dog Diseases; Dogs; Flurbiprofen; Ibuprofen

1989
Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs--1. In vitro studies of ibuprofen and flurbiprofen.
    Biochemical pharmacology, 1989, Dec-15, Volume: 38, Issue:24

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Intestine, Small; Isomerism; Kidney; Kinetics; Liver; Male; Rats; Rats, Inbred Strains

1989
Chromatographic approaches to the quality control of chiral propionate anti-inflammatory drugs and herbicides.
    Journal of chromatography, 1989, May-19, Volume: 469

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Chromatography, Gas; Flurbiprofen; Herbicides; Ibuprofen; Ketoprofen; Quality Control; Stereoisomerism

1989
Metabolic chiral inversion of anti-inflammatory 2-arylpropionates: lack of reaction in liver homogenates, and study of methine proton acidity.
    Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Guinea Pigs; Ibuprofen; Isomerism; Kinetics; Liver; Male; Naproxen; Protons; Rats; Rats, Inbred Strains; Suprofen

1988
Absorption through human skin of ibuprofen and flurbiprofen; effect of dose variation, deposited drug films, occlusion and the penetration enhancer N-methyl-2-pyrrolidone.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:1

    Topics: Acetone; Aged; Aspirin; Diffusion; Dose-Response Relationship, Drug; Female; Flurbiprofen; Humans; Ibuprofen; In Vitro Techniques; Male; Middle Aged; Permeability; Propionates; Pyrrolidinones; Skin Absorption

1985
Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2.
    Prostaglandins, leukotrienes, and medicine, 1986, Volume: 23, Issue:1

    Topics: Animals; Antineoplastic Agents; Cyclooxygenase Inhibitors; Dinoprostone; Female; Flurbiprofen; Ibuprofen; Immunization; Indomethacin; Mammary Neoplasms, Experimental; Prostaglandins E; Rats; Rats, Inbred F344

1986
Modulation of arachidonic acid metabolism in experimental arthritis induced by Salmonella enteritidis. I. Effect of ibuprofen and flurbiprofen on experimental arthritis induced by Salmonella enteritidis.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 29, Issue:2-3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Infectious; Flurbiprofen; Ibuprofen; Male; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salmonella enteritidis; Salmonella Infections

1987
Cell damage unmasks 15-lipoxygenase activity in human neutrophils.
    The Journal of biological chemistry, 1985, Jul-15, Volume: 260, Issue:14

    Topics: Acetates; Arachidonate Lipoxygenases; Aspirin; Dose-Response Relationship, Drug; Etodolac; Fluorometry; Flurbiprofen; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; L-Lactate Dehydrogenase; Lipoxygenase; Naproxen; Neutrophils; Phenylbutazone

1985
Differential in vivo effects of indomethacin, ibuprofen, and flurbiprofen on oxygen-dependent killing activities of neutrophils elicited by acute nonimmune inflammation in the rat.
    Inflammation, 1988, Volume: 12, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Indomethacin; Inflammation; Male; Neutrophils; Oxygen; Phagocytosis; Rats; Rats, Inbred Strains

1988
A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen.
    Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Flurbiprofen; Gluconeogenesis; Ibuprofen; Kinetics; Liver; Male; Phenylbutyrates; Propionates; Rats; Rats, Inbred Strains; Serum Albumin; Structure-Activity Relationship; Urea

1988
Relationships between thromboxane production, platelet aggregability, and serum concentrations of ibuprofen or flurbiprofen.
    Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:5

    Topics: Adult; Flurbiprofen; Humans; Ibuprofen; Platelet Aggregation; Propionates; Thromboxanes

1987
Pharmacological studies of antigen-induced arthritis in BALB/c mice. I. Characterization of the arthritis and the effects of steroidal and non-steroidal anti-inflammatory agents.
    Agents and actions, 1986, Volume: 18, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Dexamethasone; Female; Flurbiprofen; Ibuprofen; Indomethacin; Joints; Leukocyte Count; Lymphocytes; Mice; Mice, Inbred BALB C; Monocytes; Neutrophils; Prednisolone; Time Factors

1986
Adhesion formation and uterine tube healing in the rabbit: a controlled study of the effect of ibuprofen and flurbiprofen.
    American journal of obstetrics and gynecology, 1986, Volume: 155, Issue:6

    Topics: Animals; Fallopian Tube Diseases; Fallopian Tubes; Female; Flurbiprofen; Ibuprofen; Postoperative Care; Postoperative Complications; Preoperative Care; Propionates; Rabbits; Sterilization Reversal; Tissue Adhesions; Wound Healing

1986
Rapid HPLC-determination of ibuprofen and flurbiprofen in plasma for therapeutic drug control and pharmacokinetic applications.
    Acta pharmacologica et toxicologica, 1986, Volume: 59, Issue:5

    Topics: Adult; Chromatography, High Pressure Liquid; Flurbiprofen; Half-Life; Humans; Ibuprofen; Kinetics; Male; Propionates

1986
In vivo modulation of leukotaxis by non-steroidal anti-inflammatory drugs.
    Agents and actions, 1985, Volume: 17, Issue:1

    Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Chemotaxis, Leukocyte; Female; Flurbiprofen; Ibuprofen; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Rabbits

1985
Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2.
    Prostaglandins, leukotrienes, and medicine, 1985, Volume: 20, Issue:3

    Topics: Adenocarcinoma; Animals; Antibodies; Antineoplastic Agents; Cell Line; Cyclooxygenase Inhibitors; Dinoprostone; Female; Flurbiprofen; Ibuprofen; Immunotherapy; Indomethacin; Mammary Neoplasms, Experimental; Propionates; Prostaglandins E; Rats; Rats, Inbred F344

1985
European experience with flurbiprofen. A new analgesic/anti-inflammatory agent.
    The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A

    Topics: Aspirin; Drug Evaluation; Europe; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Propionates

1986
Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs.
    Postgraduate medical journal, 1981, Volume: 57, Issue:667

    Topics: Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Female; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Recurrence; Salicylates

1981
Experimentally induced heterotopic ossification in rats influenced by anti-inflammatory drugs.
    Scandinavian journal of rheumatology, 1983, Volume: 12, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Body Weight; Bone Matrix; Calcium Radioisotopes; Flurbiprofen; Ibuprofen; Male; Ossification, Heterotopic; Propionates; Rats; Rats, Inbred Strains

1983
In vivo interaction of nonsteroidal anti-inflammatory drugs on the locomotion of neutrophils elicited by acute non-specific inflammations in the rat--effect of indomethacin, ibuprofen and flurbiprofen.
    Biochemical pharmacology, 1984, Jul-15, Volume: 33, Issue:14

    Topics: Animals; Anti-Inflammatory Agents; Blood; Calcium Pyrophosphate; Chemotaxis, Leukocyte; Flurbiprofen; Ibuprofen; In Vitro Techniques; Indomethacin; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pleurisy; Rats; Rats, Inbred Strains

1984
Tetrazole analogues of ibuprofen and flurbiprofen.
    Archiv der Pharmazie, 1983, Volume: 316, Issue:9

    Topics: Analgesics; Animals; Azoles; Flurbiprofen; Ibuprofen; Male; Mice; Propionates; Tetrazoles

1983
Tolerability of ibuprofen and flurbiprofen in G-6-PD deficient subjects: in vitro study.
    British journal of clinical pharmacology, 1981, Volume: 11, Issue:3

    Topics: Erythrocytes; Female; Flurbiprofen; Glutathione; Glycogen Storage Disease Type I; Humans; Ibuprofen; Male; Propionates

1981
Dependency of location of salvageable myocardium on type of intervention.
    The American journal of cardiology, 1981, Volume: 48, Issue:4

    Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Flurbiprofen; Glycine; Heart; Ibuprofen; Male; Myocardial Infarction; Myocardium; Necrosis; Risk

1981
Determination of flurbiprofen and ibuprofen in dog serum with automated sample preparation.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:12

    Topics: Animals; Autoanalysis; Chromatography, High Pressure Liquid; Dogs; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Propionates

1981
Lysosomal stabilizing effects of two non-steroidal anti-inflammatory agents in the hypoxic liver.
    Naunyn-Schmiedeberg's archives of pharmacology, 1980, Volume: 311, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Cats; Female; Flurbiprofen; Ibuprofen; L-Lactate Dehydrogenase; Liver; Lysosomes; Male; Oxygen; Time Factors

1980
Effects of flurbiprofen on myocardial cell damage in acute myocardial ischemia.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 28, Issue:3

    Topics: Acute Disease; Animals; Blood Pressure; Cats; Cell Membrane; Coronary Disease; Creatine Kinase; Electrocardiography; Flurbiprofen; Heart; Heart Rate; Ibuprofen; Lysosomes; Male; Oxygenases; Platelet Aggregation; Propionates; Thromboxane A2; Vascular Resistance

1980
The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis.
    The British journal of surgery, 1980, Volume: 67, Issue:7

    Topics: Animals; Bone Resorption; Breast Neoplasms; Culture Techniques; Diphosphonates; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Mice; Neoplasms, Experimental; Osteolysis; Prostaglandin Antagonists

1980
Alterations in the electroretinogram of newborn piglets by propionic acid-derivative nonsteroidal antiinflammatory drugs but not by indomethacin and diclofenac.
    Pediatric research, 1995, Volume: 37, Issue:1

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electroretinography; Flurbiprofen; Ibuprofen; Indomethacin; Naproxen; Photoreceptor Cells; Propionates; Prostaglandins; Retina; Swine

1995
Induction of transcription factors in human T lymphocytes by aspirin-like drugs.
    Cellular immunology, 1995, Volume: 160, Issue:2

    Topics: Adult; Base Sequence; Benzoquinones; Calcium; Cell Nucleus; Diclofenac; DNA-Binding Proteins; Female; Flurbiprofen; Gene Expression Regulation; Humans; Ibuprofen; Interleukin-2; Isoenzymes; Lactams, Macrocyclic; Lymphocyte Activation; Male; Middle Aged; Molecular Sequence Data; Muromonab-CD3; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Type C Phospholipases

1995
Dermatitis herpetiformis induced by nonsteroidal anti-inflammatory drugs.
    International journal of dermatology, 1994, Volume: 33, Issue:3

    Topics: Adult; Dermatitis Herpetiformis; Flurbiprofen; Humans; Ibuprofen; Immunoglobulin A; Keratinocytes; Male; Neutrophils

1994
Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines.
    Agents and actions. Supplements, 1993, Volume: 44

    Topics: Animals; Carcinoma, Hepatocellular; Cell Count; Culture Media; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Liver Neoplasms; Liver Neoplasms, Experimental; Propionates; Rats; Species Specificity; Stereoisomerism; Tumor Cells, Cultured

1993
Stereoselectivity of biliary excretion of 2-arylpropionates in rats.
    Chirality, 1993, Volume: 5, Issue:6

    Topics: Animals; Bile; Flurbiprofen; Ibuprofen; Injections, Intravenous; Ketoprofen; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism

1993
Induction of peroxisomal beta-oxidation by nonsteroidal anti-inflammatory drugs.
    Toxicology and applied pharmacology, 1993, Volume: 118, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Clofibric Acid; Dose-Response Relationship, Drug; Flurbiprofen; Ibuprofen; Liver; Male; Microbodies; Oxidation-Reduction; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship; Triglycerides

1993
Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.
    The Journal of biological chemistry, 1996, Jan-26, Volume: 271, Issue:4

    Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Arginine; Base Sequence; Binding Sites; Cyclooxygenase Inhibitors; DNA Primers; Enzyme Inhibitors; Flurbiprofen; Glutamates; Ibuprofen; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylpropionates; Prostaglandin-Endoperoxide Synthases; Protein Structure, Tertiary; Sheep; Structure-Activity Relationship; Tyrosine

1996
Clofibric acid increases the undirectional chiral inversion of ibuprofen in rat liver preparations.
    Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clofibric Acid; Coenzyme A; Drug Interactions; Flurbiprofen; Hypolipidemic Agents; Ibuprofen; Kinetics; Liver; Male; Perfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism

1996
Effect of the enantiomers of flurbiprofen, ibuprofen, and ketoprofen on intestinal permeability.
    Journal of pharmaceutical sciences, 1996, Volume: 85, Issue:11

    Topics: Animals; Dose-Response Relationship, Drug; Flurbiprofen; Ibuprofen; Intestinal Absorption; Ketoprofen; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism

1996
Effect of concentration, pH, and preservative on in vitro transcorneal permeation of ibuprofen and flurbiprofen from non-buffered aqueous drops.
    Indian journal of experimental biology, 1997, Volume: 35, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Cornea; Flurbiprofen; Goats; Hydrogen-Ion Concentration; Ibuprofen; Ophthalmic Solutions; Permeability; Preservatives, Pharmaceutical; Water

1997
Effects of non-steroidal anti-inflammatory drugs and cyclooxygenase-2 specific inhibitors on mediator release from rat peritoneal mast cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Activation; Flurbiprofen; Histamine Release; Ibuprofen; Immunoglobulin E; Indans; Indomethacin; Isoenzymes; Male; Mast Cells; Naphthaleneacetic Acids; Nitrobenzenes; Peritoneal Cavity; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides

1998
Effect of chemical structure on the release of certain propionic acid derivatives from their dosage forms.
    Drug development and industrial pharmacy, 1998, Volume: 24, Issue:5

    Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Dosage Forms; Drug Compounding; Drug Stability; Drug Storage; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Molecular Structure; Naproxen; Propionates; Suppositories

1998
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
    Archives of biochemistry and biophysics, 1999, Feb-15, Volume: 362, Issue:2

    Topics: Aging; Animals; Arachidonic Acids; Brain; Cell Extracts; Cell Survival; Dose-Response Relationship, Drug; Endocannabinoids; Flurbiprofen; Glioma; Hydrolysis; Ibuprofen; Inhibitory Concentration 50; Ketorolac; Kinetics; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors; Tolmetin; Tumor Cells, Cultured

1999
Stereoselective and substrate-dependent inhibition of hepatic mitochondria beta-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac.
    Biochemical pharmacology, 1999, Apr-01, Volume: 57, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coenzyme A; Flurbiprofen; Ibuprofen; Ketorolac; Lipid Metabolism; Male; Mitochondria, Liver; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Palmitic Acid; Rats; Rats, Wistar; Stereoisomerism; Tolmetin

1999
Direct enantiomeric resolution of some 2-arylpropionic acids using (-)-brucine-impregnated thin-layer chromatography.
    Biomedical chromatography : BMC, 1999, Volume: 13, Issue:4

    Topics: Chromatography, Thin Layer; Flurbiprofen; Ibuprofen; Stereoisomerism; Strychnine

1999
R- and S-isomers of nonsteroidal anti-inflammatory drugs differentially regulate cytokine production.
    European cytokine network, 2000, Volume: 11, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dinoprostone; Female; Flurbiprofen; Ibuprofen; In Vitro Techniques; Interleukin-10; Interleukin-6; Ketoprofen; Lipopolysaccharides; Macrophages, Peritoneal; Mice; RNA, Messenger; Stereoisomerism; Tumor Necrosis Factor-alpha

2000
Directed control of electroosmotic flow in nonaqueous electrolytes using poly(ethylene glycol) coated capillaries.
    Electrophoresis, 2001, Volume: 22, Issue:4

    Topics: Acetonitriles; Benzoic Acid; Buffers; Chemical Phenomena; Chemistry, Physical; Electrolytes; Electrophoresis, Capillary; Flurbiprofen; Ibuprofen; Methanol; Osmosis; Phenylacetates; Polyethylene Glycols; Propionates; Reproducibility of Results; Salicylic Acid; Silicon Dioxide; Solvents; Sulindac; Surface Properties; Water

2001
Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
    Biochemistry, 2001, May-01, Volume: 40, Issue:17

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Catalysis; Crystallization; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Enzyme Activation; Flurbiprofen; Ibuprofen; Isoenzymes; Kinetics; Male; Phenylacetates; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protein Conformation; Sheep; Structure-Activity Relationship

2001
Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Mar-15, Volume: 22, Issue:6

    Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Celecoxib; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Flurbiprofen; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Ibuprofen; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Nitric Oxide; Presenilin-1; Pyrazoles; Sulfonamides; Treatment Outcome

2002
Identification of drug-binding sites on human serum albumin using affinity capillary electrophoresis and chemically modified proteins as buffer additives.
    Electrophoresis, 2002, Volume: 23, Issue:6

    Topics: 2-Hydroxy-5-nitrobenzyl Bromide; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Buffers; Chemical Warfare Agents; Dextrans; Electrophoresis, Capillary; Flurbiprofen; Humans; Ibuprofen; Molecular Structure; Serum Albumin; Suprofen; Tetranitromethane; Tryptophan; Warfarin

2002
The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.
    Cancer investigation, 2002, Volume: 20, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle; Cell Division; Diclofenac; Fibrosarcoma; Flurbiprofen; Ibuprofen; In Vitro Techniques; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Survival Rate; Tumor Cells, Cultured

2002
Selective inhibition of Abeta42 production by NSAID R-enantiomers.
    Journal of neurochemistry, 2002, Volume: 83, Issue:4

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Ibuprofen; Kidney; Mutation; NF-kappa B; Peptide Fragments; Peptides; Stereoisomerism; Transfection

2002
Enhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis.
    Electrophoresis, 2003, Volume: 24, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclodextrins; Electrophoresis, Capillary; Fenoprofen; Flurbiprofen; Ibuprofen; Ketoprofen; Static Electricity; Stereoisomerism

2003
Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:3

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Endocannabinoids; Extracellular Space; Flurbiprofen; Glioma; Hydrogen-Ion Concentration; Hydrolysis; Ibuprofen; Intracellular Space; Polyunsaturated Alkamides; Rats; Stereoisomerism; Time Factors; Tumor Cells, Cultured

2003
Modeling of adhesion in tablet compression--I. Atomic force microscopy and molecular simulation.
    Journal of pharmaceutical sciences, 2003, Volume: 92, Issue:4

    Topics: Adhesiveness; Chemistry, Pharmaceutical; Compressive Strength; Drug Compounding; Flurbiprofen; Ibuprofen; Iron; Ketoprofen; Microscopy, Atomic Force; Models, Molecular; Surface Properties; Tablets; X-Ray Diffraction

2003
Simultaneous chiral discrimination of multiple profens by cyclodextrin-modified capillary electrophoresis in normal and reversed polarity modes.
    Electrophoresis, 2003, Volume: 24, Issue:15

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclodextrins; Electrophoresis, Capillary; Flurbiprofen; Hexadimethrine Bromide; Ibuprofen; Ketoprofen; Phenylpropionates; Stereoisomerism

2003
Modeling of adhesion in tablet compression. II. Compaction studies using a compaction simulator and an instrumented tablet press.
    Journal of pharmaceutical sciences, 2004, Volume: 93, Issue:2

    Topics: Adhesiveness; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Drug Compounding; Flurbiprofen; Ibuprofen; Ketoprofen; Lubrication; Pressure; Surface Properties; Tablets

2004
Investigation of the release test method for the topical application of pharmaceutical preparations: release test of cataplasm including nonsteroidal anti-inflammatory drugs using artificial sweat.
    Chemical & pharmaceutical bulletin, 2004, Volume: 52, Issue:2

    Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Kinetics; Solubility; Sweat; Tablets

2004
Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cholestasis; Diclofenac; Drug Therapy, Combination; Female; Flurbiprofen; Hepatocytes; Humans; Ibuprofen; Ketoprofen; Liver; Male; Meloxicam; Middle Aged; Niflumic Acid; Primary Health Care; Salicylates; Sex Distribution; Statistics, Nonparametric; Thiazines; Thiazoles; Time Factors

2004
S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity.
    Journal of neuroimmunology, 2004, Volume: 152, Issue:1-2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Culture Media, Conditioned; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Ibuprofen; Microglia; Monocytes; Neuroblastoma; Neurons; Stereoisomerism

2004
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:5

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flurbiprofen; Ibuprofen; Isoenzymes; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thrombosis

2004
Separation strategy for acidic chiral pharmaceuticals with capillary electrochromatography on polysaccharide stationary phases.
    Electrophoresis, 2005, Volume: 26, Issue:4-5

    Topics: Acetonitriles; Buffers; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Flurbiprofen; Hexobarbital; Hydrogen-Ion Concentration; Ibuprofen; Pharmaceutical Preparations; Polysaccharides; Stereoisomerism; Temperature; Warfarin

2005
Determination of ibuprofen and flurbiprofen in pharmaceuticals by capillary zone electrophoresis.
    Journal of pharmaceutical and biomedical analysis, 2006, Jun-16, Volume: 41, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Electrophoresis, Capillary; Flurbiprofen; Ibuprofen; Pharmaceutical Preparations; Reproducibility of Results; Stereoisomerism; Tablets

2006
Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin.
    Pharmaceutical research, 2006, Volume: 23, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Biological Transport; Blood-Brain Barrier; Brain; Capillary Permeability; Flurbiprofen; Ibuprofen; Indomethacin; Kinetics; Male; Perfusion; Protein Binding; Rats; Rats, Wistar; Serum Albumin, Bovine

2006
Factors affecting the formation of eutectic solid dispersions and their dissolution behavior.
    Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:2

    Topics: Drug Carriers; Fenofibrate; Flurbiprofen; Griseofulvin; Ibuprofen; Models, Chemical; Molecular Weight; Naproxen; Polyethylene Glycols; Sodium Dodecyl Sulfate; Solubility; Transition Temperature; Water

2007
Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Male; Naproxen; Propionates; Rats; Stomach Ulcer; Structure-Activity Relationship; Thiadiazoles; Thiazoles

2007
The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.
    Cancer research, 2007, Apr-01, Volume: 67, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Ibuprofen; Male; Nerve Tissue Proteins; Prostatic Neoplasms; Receptors, Nerve Growth Factor; RNA, Small Interfering; Transfection; Up-Regulation

2007
The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells.
    Cancer research, 2007, Dec-01, Volume: 67, Issue:23

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Eukaryotic Initiation Factor-4E; Flurbiprofen; Humans; Ibuprofen; Immunoblotting; Immunoprecipitation; Luciferases; Male; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Receptors, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Small Interfering; Signal Transduction; Tumor Cells, Cultured

2007
Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner.
    Mechanisms of ageing and development, 2008, Volume: 129, Issue:12

    Topics: Aspirin; Caveolin 1; Celecoxib; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fibroblasts; Flurbiprofen; Humans; Ibuprofen; Kinetics; Models, Biological; NF-kappa B; Nitrobenzenes; Pyrazoles; Reactive Oxygen Species; Skin; Skin Aging; Sulfonamides; Tumor Suppressor Protein p53

2008
Tarenflurbil protection from cytotoxicity is associated with an upregulation of neurotrophins.
    Journal of Alzheimer's disease : JAD, 2008, Volume: 15, Issue:3

    Topics: Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain-Derived Neurotrophic Factor; Cell Line; Cell Survival; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flurbiprofen; Hydrogen Peroxide; Ibuprofen; Nerve Growth Factors; Neurons; Oxidants; Reverse Transcriptase Polymerase Chain Reaction; RNA; Up-Regulation

2008
CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
    British journal of pharmacology, 2009, Volume: 156, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cyclopropanes; Flurbiprofen; Humans; Ibuprofen; Learning Disabilities; Memory; Mice; Mice, Transgenic; Microglia; Mutation; Peptide Fragments; Plaque, Amyloid

2009
Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach.
    Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carbon Isotopes; Crystallization; Drug Stability; Flurbiprofen; Hot Temperature; Humidity; Hydrogen Bonding; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Structure; Molecular Weight; Naproxen; Phase Transition; Phenylbutyrates; Polymers; Povidone; Static Electricity; X-Ray Diffraction

2009
Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 22, Issue:4

    Topics: Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Blotting, Western; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclooxygenase 2; Cyclopropanes; Cytoskeleton; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flurbiprofen; Ibuprofen; Immunohistochemistry; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction

2010
Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Dinoprostone; Dose-Response Relationship, Drug; Female; Flurbiprofen; Humans; Ibuprofen; Leukocytes; Male; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2

2010
NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway.
    Molecular cancer research : MCR, 2010, Volume: 8, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Movement; Flurbiprofen; Growth Differentiation Factor 15; Humans; Ibuprofen; Imidazoles; Male; MAP Kinase Signaling System; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Pyridines; Receptors, Nerve Growth Factor; RNA, Small Interfering; Transforming Growth Factor beta1

2010
The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.
    Journal of molecular neuroscience : MN, 2011, Volume: 45, Issue:1

    Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cells, Cultured; Cyclooxygenase Inhibitors; Cyclopropanes; Diet; Disease Models, Animal; Flurbiprofen; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Ibuprofen; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Phosphorylation; Signal Transduction; tau Proteins

2011
Lack of enantiomeric influence on the brain cytoprotective effect of ibuprofen and flurbiprofen.
    Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 384, Issue:2

    Topics: Animals; Brain; Cyclooxygenase Inhibitors; Cytokines; Cytoprotection; Dinoprostone; Flurbiprofen; Hypoxia, Brain; Ibuprofen; In Vitro Techniques; Lipid Peroxidation; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stereoisomerism; Tyrosine

2011
Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3.
    Biopharmaceutics & drug disposition, 2011, Volume: 32, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Humans; Ibuprofen; Inhibitory Concentration 50; Naproxen; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Stereoisomerism; Xenopus laevis

2011
Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by cocrystallization with nicotinamide.
    Pharmaceutical research, 2012, Volume: 29, Issue:7

    Topics: Analgesics; Calorimetry, Differential Scanning; Crystallization; Flurbiprofen; Ibuprofen; Models, Molecular; Niacinamide; Powder Diffraction; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; Vitamin B Complex; Wettability; X-Ray Diffraction

2012
Enantiomeric resolution of ibuprofen and flurbiprofen in human plasma by SPE-chiral HPLC methods.
    Combinatorial chemistry & high throughput screening, 2012, Volume: 15, Issue:6

    Topics: Analgesics; Chromatography, High Pressure Liquid; Flurbiprofen; Humans; Ibuprofen; Sensitivity and Specificity; Solid Phase Extraction; Stereoisomerism

2012
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin

2012
In vitro investigations of α-amylase mediated hydrolysis of cyclodextrins in the presence of ibuprofen, flurbiprofen, or benzo[a]pyrene.
    Carbohydrate research, 2012, Nov-15, Volume: 362

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; alpha-Amylases; alpha-Cyclodextrins; Animals; Benzo(a)pyrene; beta-Cyclodextrins; Drug Stability; Flurbiprofen; gamma-Cyclodextrins; Hydrolysis; Ibuprofen; Kinetics; Pancreas; Solubility; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Swine

2012
Sensing chiral drugs by using CdSe/ZnS nanoparticles capped with N-acetyl-L-cysteine methyl ester.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Aug-12, Volume: 19, Issue:33

    Topics: Acetylcysteine; Cadmium Compounds; Circular Dichroism; Esters; Flurbiprofen; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Quantum Dots; Selenium Compounds; Spectrometry, Fluorescence; Stereoisomerism; Sulfides; Zinc Compounds

2013
Separation efficiency of dual-selector systems in capillary electrophoresis.
    Journal of chromatography. A, 2014, Feb-21, Volume: 1330

    Topics: Electrophoresis, Capillary; Flurbiprofen; Ibuprofen; Stereoisomerism

2014
Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Animals; Brain; Cyclooxygenase Inhibitors; Endocannabinoids; Flurbiprofen; Ibuprofen; Rats; Rats, Sprague-Dawley; Rats, Wistar

2014
Determination of thermodynamic values of acidic dissociation constants and complexation constants of profens and their utilization for optimization of separation conditions by Simul 5 Complex.
    Journal of chromatography. A, 2014, Oct-17, Volume: 1364

    Topics: Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Computer Simulation; Electrophoresis, Capillary; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Naproxen; Osmolar Concentration; Software; Thermodynamics; Viscosity

2014
Marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes.
    Archiv der Pharmazie, 2015, Volume: 348, Issue:1

    Topics: Arachidonate 5-Lipoxygenase; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Flurbiprofen; Ibuprofen; Lipoxygenase Inhibitors; Molecular Structure; Naproxen; Propionates; Structure-Activity Relationship

2015
Parallel artificial liquid membrane extraction of acidic drugs from human plasma.
    Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:10

    Topics: Calibration; Chromatography, High Pressure Liquid; Diclofenac; Equipment Design; Flurbiprofen; Gemfibrozil; Humans; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Liquid-Liquid Extraction; Membranes, Artificial; Pharmaceutical Preparations; Polypropylenes; Polyvinyls

2015
[[Chiral separation of five arylpropionic acid drugs and determination of their enantiomers in pharmaceutical preparations by reversed-phase high performance liquid chromatography with cellulose-tris-(4-methylbenzoate) stationary phase]].
    Se pu = Chinese journal of chromatography, 2014, Volume: 32, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzopyrans; Cellulose; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Flurbiprofen; Ibuprofen; Naproxen; Phenylpropionates; Propionates; Stereoisomerism

2014
Cyclosporin A-sensitive cytotoxicity of flurbiprofen non-stereoselectively mediated by cytochrome P450 metabolism in three-dimensional cultured rat hepatocytes.
    The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:10

    Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochrome P-450 Enzyme System; Flurbiprofen; Hepatocytes; Ibuprofen; L-Lactate Dehydrogenase; Male; Mitochondria; Naproxen; Phenylpropionates; Rats; Rats, Wistar; Stereoisomerism

2015
Do Different Cyclooxygenase Inhibitors Impair Rotator Cuff Healing in a Rabbit Model?
    Chinese medical journal, 2015, Sep-05, Volume: 128, Issue:17

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Celecoxib; Cyclooxygenase 2 Inhibitors; Flurbiprofen; Ibuprofen; Male; Rabbits; Rotator Cuff; Tendon Injuries; Wound Healing

2015
Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Amidohydrolases; Aminopyridines; Animals; Brain; Cyclooxygenase Inhibitors; Drug Design; Flurbiprofen; HeLa Cells; Humans; Hydrolysis; Ibuprofen; Inhibitory Concentration 50; Kinetics; Male; Mice; Molecular Dynamics Simulation; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Stereoisomerism

2015
Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations.
    The journal of physical chemistry. A, 2016, Feb-25, Volume: 120, Issue:7

    Topics: beta-Cyclodextrins; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Kinetics; Ligands; Macromolecular Substances; Pyronine; Thermodynamics

2016
Enantioselective simultaneous analysis of selected pharmaceuticals in environmental samples by ultrahigh performance supercritical fluid based chromatography tandem mass spectrometry.
    Analytica chimica acta, 2016, Aug-31, Volume: 934

    Topics: Aminorex; Carbazoles; Chloramphenicol; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Flurbiprofen; Humans; Ibuprofen; Ifosfamide; Imidazoles; Indoprofen; Molecular Structure; Naproxen; Ofloxacin; Omeprazole; Praziquantel; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry; Tetramisole; Water Pollutants, Chemical

2016
Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation.
    International journal of molecular sciences, 2017, Jan-18, Volume: 18, Issue:1

    Topics: Animals; Apoptosis; Caspase 3; Cell Nucleus; Cerebral Cortex; Cyclopropanes; Cytochromes c; Enzyme Activation; Flurbiprofen; Glucose; Glycogen Synthase Kinase 3 beta; Ibuprofen; Mice, Inbred C57BL; Necrosis; Neurons; Neuroprotective Agents; Oxygen; p38 Mitogen-Activated Protein Kinases; Transcription Factor RelA

2017
Levetiracetam+nonsteroidal anti-inflammatory drug binary systems: A contribution to the development of new solid dosage forms.
    International journal of pharmaceutics, 2017, Nov-25, Volume: 533, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Combinations; Drug Liberation; Flurbiprofen; Ibuprofen; Ketoprofen; Levetiracetam; Naproxen; Piracetam; Stereoisomerism

2017
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-15, Volume: 112

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Flurbiprofen; Glucuronides; Ibuprofen; Ketoprofen; Male; Microsomes, Liver; Naproxen; Propionates; Protein Binding; Rats, Wistar

2018
Dried blood spots and parallel artificial liquid membrane extraction-A simple combination of microsampling and microextraction.
    Analytica chimica acta, 2018, Jun-07, Volume: 1009

    Topics: Amitriptyline; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Fenoprofen; Flurbiprofen; Healthy Volunteers; Humans; Ibuprofen; Ketoprofen; Liquid-Liquid Extraction; Membranes, Artificial; Quetiapine Fumarate; Tandem Mass Spectrometry

2018
Carbonic Anhydrase Inhibitory Potential of 1,2,4-triazole-3-thione Derivatives of Flurbiprofen, Ibuprofen and 4-tert-butylbenzoic Hydrazide: Design, Synthesis, Characterization, Biochemical Evaluation, Molecular Docking and Dynamic Simulation Studies.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2019, Volume: 15, Issue:3

    Topics: Benzoates; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Flurbiprofen; Ibuprofen; Molecular Docking Simulation; Schiff Bases; Spectrum Analysis; Structure-Activity Relationship; Triazoles

2019
Simultaneous enantiomeric analysis of non-steroidal anti-inflammatory drugs in environment by chiral LC-MS/MS: A pilot study in Beijing, China.
    Ecotoxicology and environmental safety, 2019, Jun-15, Volume: 174

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Beijing; Chromatography, High Pressure Liquid; Environmental Monitoring; Flurbiprofen; Ibuprofen; Naproxen; Pilot Projects; Rivers; Stereoisomerism; Tandem Mass Spectrometry; Water Pollutants, Chemical

2019
Switchable-hydrophilicity solvent liquid-liquid microextraction of non-steroidal anti-inflammatory drugs from biological fluids prior to HPLC-DAD determination.
    Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Centrifugation; Chromatography, High Pressure Liquid; Etodolac; Flurbiprofen; Humans; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Ketoprofen; Linear Models; Liquid Phase Microextraction; Milk, Human; Organic Chemicals; Reproducibility of Results; Saliva; Sodium Hydroxide; Solvents

2019
Hybrid monoliths with metal-organic frameworks in spin columns for extraction of non-steroidal drugs prior to their quantitation by reversed-phase HPLC.
    Mikrochimica acta, 2019, 11-11, Volume: 186, Issue:12

    Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Limit of Detection; Metal-Organic Frameworks; Methylmethacrylates; Solid Phase Microextraction

2019
UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Jun-01, Volume: 1146

    Topics: Biological Assay; Calicheamicins; Chromatography, High Pressure Liquid; Doxorubicin; Flurbiprofen; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Immunoconjugates; Irinotecan; Ketoprofen; Maytansine; Molecular Conformation; Norfloxacin; Pentachlorophenol; Protein Multimerization; Structure-Activity Relationship; Tandem Mass Spectrometry; Tolnaftate

2020
Applicability of capillary electrophoresis-frontal analysis for displacement studies: Effect of several drugs on l-tryptophan and lidocaine binding to human serum albumin.
    Journal of separation science, 2020, Volume: 43, Issue:22

    Topics: Binding Sites; Chlorpropamide; Diclofenac; Electrophoresis, Capillary; Flurbiprofen; Humans; Ibuprofen; Lidocaine; Phenylbutazone; Serum Albumin, Human; Tolbutamide; Tryptophan

2020
Direct distinction of ibuprofen and flurbiprofen enantiomers by ion mobility mass spectrometry of their ternary complexes with metal cations and cyclodextrins in the gas phase.
    Journal of separation science, 2021, Volume: 44, Issue:12

    Topics: Calcium; Cations; Coordination Complexes; Cyclodextrins; Flurbiprofen; Ibuprofen; Ion Mobility Spectrometry; Lithium; Molecular Structure; Sodium; Stereoisomerism

2021
Cisplatin-cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line.
    Dalton transactions (Cambridge, England : 2003), 2022, Jan-17, Volume: 51, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Humans; Ibuprofen; Molecular Structure; Naproxen; Platinum; Silicon Dioxide

2022
Modeling of Adhesion in Tablet Compression at the Molecular Level Using Thermal Analysis and Molecular Simulations.
    Molecular pharmaceutics, 2022, 01-03, Volume: 19, Issue:1

    Topics: Adhesiveness; Calorimetry, Differential Scanning; Compressive Strength; Flurbiprofen; Ibuprofen; Ketoprofen; Models, Molecular; Tablets

2022
Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.
    International journal of molecular sciences, 2022, Jan-19, Volume: 23, Issue:3

    Topics: Acetaminophen; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; COVID-19; Disease Progression; Enzyme Activation; Etoricoxib; Flurbiprofen; Gene Expression Regulation, Enzymologic; Humans; Ibuprofen; Male; Mice; Mice, Inbred C57BL; SARS-CoV-2; Virus Internalization

2022
Disposable stochastic sensors for fast analysis of ibuprofen, ketoprofen, and flurbiprofen in their topical pharmaceutical formulations.
    Journal of pharmaceutical and biomedical analysis, 2022, Jun-05, Volume: 215

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbon; Copper; Drug Compounding; Flurbiprofen; Ibuprofen; Ketoprofen

2022
An Evolving Role of Aqueous Piperazine to Improve the Solubility of Non-Steroidal Anti-Inflammatory Drugs.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Flurbiprofen; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutazone; Piperazine; Powders; Salts; Solubility; Spectroscopy, Fourier Transform Infrared; Sulindac; Water; X-Ray Diffraction

2022
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine.
    Chemical & pharmaceutical bulletin, 2023, Volume: 71, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Famotidine; Flurbiprofen; Ibuprofen; Naproxen; Taste

2023
New Acetamide-Sulfonamide-Containing Scaffolds: Antiurease Activity Screening, Structure-Activity Relationship, Kinetics Mechanism, Molecular Docking, and MD Simulation Studies.
    Molecules (Basel, Switzerland), 2023, Jul-13, Volume: 28, Issue:14

    Topics: Canavalia; Enzyme Inhibitors; Flurbiprofen; Ibuprofen; Kinetics; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Sulfacetamide; Sulfamerazine; Sulfanilamide; Sulfonamides; Urease

2023