ibuprofen has been researched along with flurbiprofen in 183 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (22.40) | 18.7374 |
| 1990's | 36 (19.67) | 18.2507 |
| 2000's | 45 (24.59) | 29.6817 |
| 2010's | 49 (26.78) | 24.3611 |
| 2020's | 12 (6.56) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N | 1 |
| Carey, KN; Casillas, EG; Gupta, K; Kaub, CJ; Loll, PJ; Selinsky, BS | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A | 1 |
| Caron, G; Ermondi, G | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Amir, M; Javed, SA; Kumar, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chuang, S; Horne, J; Porter, CJ; Scanlon, MJ; Velkov, T | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Kumar, M; Sinha, VR; Thareja, S | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Headey, SJ; Hughes, ML; Laguerre, A; Mohanty, B; Patil, R; Porter, CJ; Scanlon, MJ; Wielens, J; Williams, ML | 1 |
| Brewster, C; Deering-Rice, CE; Reilly, CA; Rose, TM | 1 |
| Aytaç, PS; Çetin-Atalay, R; Durmaz, I; Houston, DR; Tozkoparan, B | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Lund, C; Lynagh, T; Pless, SA; Romero-Rojo, JL | 1 |
| Basu, P; Elias, R; Fridman, M | 1 |
| Anderson, JA; Buchanan, WW; Lee, P; Miller, J; Webb, J | 1 |
| Nozu, K | 1 |
| Briney, WG; Giansiracusa, J; Mena, HR; Ward, JR; Wolski, KP; Zuckner, J | 1 |
| Alphen, GW; Wilhelm, PB | 1 |
| Ehrlich, GE; Giansiracusa, J; Gray, J; Mena, HR; Ward, J | 1 |
| Birkett, DJ; Sudlow, G; Wade, DN | 1 |
| Fitzpatrick, FA; Wynalda, MA | 1 |
| Ghosh, P; Horsburgh, BA; McKenzie, LS; Taylor, TK | 1 |
| Lands, WE; Rome, LH | 1 |
| Masumoto, S; Okumura, M; Takase, K | 1 |
| Hall, SD; Hassanzadeh-Khayyat, M; Knadler, MP; Mayer, PR | 1 |
| Baillie, TA; Knights, KM; Talbot, UM | 1 |
| Bundgaard, H; Mørk, N | 1 |
| Brune, K; Geisslinger, G; Menzel-Soglowek, S; Mollenhauer, J | 1 |
| Adams, SS | 1 |
| Day, RO; Geisslinger, G; Hall, I; Williams, KM; Zhao, B | 1 |
| Goldhaber, P; Hall, CM; Howell, TH; Jeffcoat, MK; Johnson, HG; Odle, BM; Offenbacher, S; Smith, MA; Williams, RC | 1 |
| Fleury, AA; Hammond, BF; Hersh, EV | 1 |
| Kaufhold, J; McCabe, K; Wilkowski, M | 1 |
| Fritz, ME; Green, MD; Mayambala, CS; Odle, BM; Offenbacher, S; Sena, FJ; Smith, MA; van Dyke, TE; Yeh, KC | 1 |
| Mayer, JM | 1 |
| Coates, J; Friedman, H; Jamali, F; Russell, AS; Skeith, KJ | 1 |
| Day, RO; Graham, GG; Knihinicki, RD; Williams, KM | 1 |
| Boney, RS; Goldenberg, MM; Rosenbaum, JT; Tilden, ME | 1 |
| Butler, DP; Dionne, RA; Hargreaves, KM; Troullos, ES | 1 |
| Hall, SD; Knadler, MP | 1 |
| Tempowski, JH | 1 |
| Day, RO; Knihinicki, RD; Williams, KM | 1 |
| Hargreaves, KM; Jackson, DL; Moore, PA | 1 |
| Blessington, B; Crabb, N; Karkee, S; Northage, A | 1 |
| Bartolucci, C; Maître, JM; Mayer, JM; Testa, B | 1 |
| Akhter, SA; Barry, BW | 1 |
| Karmali, RA; Marsh, J | 2 |
| Karmali, RA | 1 |
| Denlinger, RH; Elliott, GA; Purmalis, A; VanderMeer, DA | 1 |
| Crittenden, N; Fitzpatrick, F; McGee, J; McGuire, J | 1 |
| Giroud, JP; Hakim, J; Perianin, A | 1 |
| Castell, JV; Gómez-Lechón, MJ; Larrauri, A | 1 |
| Cox, SR; Gumbleton, TJ; Smith, RB; VanderLugt, JT | 1 |
| Crossley, MJ; Hunneyball, IM; Spowage, M | 1 |
| Dawood, MY; Jarrett, JC | 1 |
| Askholt, J; Nielsen-Kudsk, F | 1 |
| diZerega, GS; Nakamura, RM; Shimanuki, T | 1 |
| Buchanan, WW; Kassam, YB | 1 |
| Rampton, DS; Sladen, GE | 1 |
| Bauer, FC; Lindholm, TS; Nilsson, OS; Törnkvist, H | 1 |
| Ito, T; Miyamoto, S; Murakami, T; Sato, M; Sayama, T; Sudo, M; Suzuki, A; Tamura, M; Tazawa, M; Yoshida, M | 1 |
| Giroud, JP; Hakim, J; Perianin, A; Roch-Arveiller, M | 1 |
| Cima, L; Fabbri, G; Giusti, P; Rampa, A; Valenti, P | 1 |
| Baxi, AJ; Gupta, KC; Kulkarni, VN; Pispati, PK; Sheth, UK; Valame, SP | 1 |
| Darsee, JR; Kloner, RA | 1 |
| Beaubien, LJ; Rahn, PD; Sears, DJ; Snider, BG | 1 |
| Araki, H; Lefer, AM | 1 |
| Carrow, BA; Lefer, AM; Smith, EF | 1 |
| Galasko, CS; Lacey, E; Rushton, S; Samuel, AW | 1 |
| Chemtob, S; Hanna, N; Lachapelle, P; Orquin, J; Roy, MS; Varma, DR | 1 |
| Dang, H; Flescher, E; Fossum, D; Ledbetter, JA; Ogawa, N; Talal, N; Vela-Roch, N | 1 |
| Lafontaine, N; Rochette, L; Rozenfarb, E; Tousignant, J | 1 |
| Brune, K; Geisslinger, G; Menzel-Soglowek, S | 1 |
| Beck, WS; Brune, K; Geisslinger, G; Menzel, S | 1 |
| Howell, TH; Williams, RC | 1 |
| Eacho, PI; Foxworthy, PS; Perry, DN | 1 |
| Bhattacharyya, DK; Garavito, M; Lecomte, M; Rieke, CJ; Smith, WL | 1 |
| Etter, JC; Mayer, JM; Roy-de Vos, M; Testa, B | 1 |
| Kelkar, MG; Nayak, PJ; Pargal, A | 1 |
| Davies, NM; Jamali, F; Russell, AS; Wright, MR | 1 |
| Derendorf, H; Grundy, BL; Suri, A | 1 |
| Jamali, F; Mehvar, R | 1 |
| Gupta, M; Majumdar, DK | 1 |
| Lau, HY; Stenton, GR | 1 |
| el-Bary, AA; el-Nabarawi, MA; Mohamed, MI | 1 |
| Fowler, CJ; Janson, U; Johnson, RM; Norström, K; Stenström, A; Tiger, G; Wahlström, G | 1 |
| Browne, GS; Day, RO; Ellis, BA; Nelson, C; Nguyen, T; Williams, KM | 1 |
| Bhushan, R; Thiongo, GT | 1 |
| Allegretti, M; Bertini, R; Biordi, L; Caselli, G; Martinotti, S; Marullo, A; Mascagni, P; Sabbatini, V | 1 |
| Belder, D; Husmann, H; Warnke, J | 1 |
| Gupta, K; Loll, PJ; Selinsky, BS; Sharkey, CT | 1 |
| Connor, KE; Coppola, D; DiCarlo, G; Gordon, MN; Jantzen, PT; Morgan, D; Rojiani, AM; Wallace, JL; Wenk, GL | 1 |
| Austin, J; Hage, DS; Kim, HS | 1 |
| Egyed, A; Fedorocko, P; Hofer, M; Hoferová, Z; Hofmanová, J; Kozubík, A; Minksová, K; Soucek, K; Znojil, V | 1 |
| Beech, W; Chu, T; Cole, GM; Morihara, T; Ubeda, O | 1 |
| Abushoffa, AM; Crommen, J; Fillet, M; Hubert, P; Servais, AC | 1 |
| Fowler, CJ; Holt, S | 1 |
| Bateman, SD; Erck, R; Li, T; Morris, KR; Wang, JJ | 1 |
| Goto, J; Kim, J; Kim, JH; Kim, KR; La, S | 1 |
| Bateman, SD; Guillot, MA; Morris, KR; Wang, JJ | 1 |
| Kobayashi, D; Kogo, T; Morimoto, Y; Numajiri, S; Shimamura, T; Tairabune, T; Ueda, H | 1 |
| Bagheri, H; Lacroix, I; Lapeyre-Mestre, M; Montastruc, JL; Pathak, A | 1 |
| Klegeris, A; Maguire, J; McGeer, PL | 1 |
| Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A | 1 |
| Maftouh, M; Mangelings, D; Massart, DL; Matthijs, N; Tanret, I; Vander Heyden, Y | 1 |
| Karaman, AI; Polat, O | 1 |
| Praticò, D; Townsend, KP | 1 |
| Hamoudová, R; Pospísilová, M | 1 |
| Mandula, H; Parepally, JM; Smith, QR | 1 |
| Hornung, S; Krill, SL; Vippagunta, SR; Wang, Z | 1 |
| El-Fayomi, HM; El-Sadek, ME; Lashine, el-SM; Metwally, KA; Yaseen, SH | 1 |
| Djakiew, D; Khwaja, F; Quann, EJ; Zavitz, KH | 1 |
| Ji, H; Peng, SX; Zhang, YH | 1 |
| Djakiew, D; Khwaja, F; Quann, EJ | 1 |
| Han, JA; Kim, SR; Lee, ME; Park, JH; Park, JS; Park, SC | 1 |
| Andrews, PM; Hoe, HS; Rebeck, GW; Zhao, X | 1 |
| Cenacchi, V; Facchinetti, F; Hutter-Paier, B; Imbimbo, BP; Lanzillotta, A; Pizzi, M; Villetti, G; Volta, R; Windisch, M | 1 |
| Angeletti, M; Censi, R; Di Martino, P; Gashi, Z; Gobetto, R; Malaj, L; Masic, A; Mozzicafreddo, M | 1 |
| Baltrons, MA; Carriba, P; Galea, E; García, A; Lichtenstein, MP; Peterson, JR; Wojciak-Stothard, B | 1 |
| De la Cruz, JP; Gonzalez-Correa, JA; Jebrouni, N; Lopez-Villodres, JA; Reyes, JJ; Ruiz-Moreno, MI | 1 |
| Djakiew, D; Wynne, S | 1 |
| Baiguera, C; Benarese, M; Branca, C; Hutter-Paier, B; Imbimbo, BP; Lanzillotta, A; Pizzi, M; Sarnico, I; Spano, P; Windisch, M | 1 |
| De La Cruz, JP; González-Correa, JA; Guerrero, A; López-Villodres, JA; Muñoz-Marin, J; Reyes, JJ | 1 |
| Aoki, Y; Honjo, H; Iwamoto, K; Uwai, Y | 1 |
| Chen, M; Chow, AH; Chow, SF; Shi, L; Sun, CC | 1 |
| Aboul-Enein, HY; Ali, I; Hussain, I; Saleem, K | 1 |
| Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y | 1 |
| Holm, R; Jørgensen, EB; Larsen, KL; Lumholdt, LR | 1 |
| Bouchet, LM; de la Guardia, M; Delgado-Pérez, T; Galian, RE; Pérez-Prieto, J | 1 |
| Arimori, K; Ogata, K; Osaki, T; Ozaki, M; Setoguchi, N; Takamura, N; Tokunaga, J | 1 |
| Dubský, P; Gaš, B; Müllerová, L | 1 |
| Fowler, CJ; Karlsson, J | 1 |
| Gaš, B; Riesová, M; Svobodová, J; Tošner, Z; Ušelová, K; Zusková, I | 1 |
| Dimoglo, A; Erçetin, T; Esiringu, İ; Gülcan, HO; Öz, D; Şahin, MF; Şahin, Y; Ünlü, S | 1 |
| Gjelstad, A; Pedersen-Bjergaard, S; Roldán-Pijuán, M | 1 |
| Chen, Z; Fan, H; Huang, X; Luo, A; Wan, Q; Wu, X; Zang, L | 1 |
| Funakami, Y; Kato, Y; Nagai, N; Tanino, T | 1 |
| Jiang, CY; Li, FL; Li, X; Li, Y; Lu, Y; Zhuo, HW | 1 |
| Catalanotti, B; Congiu, C; Deplano, A; Fowler, CJ; Karlsson, J; Luque, FJ; Morgillo, CM; Novellino, E; Onnis, V; Pedone, E; Smaldone, G; Svensson, M | 1 |
| Gu, J; Guo, T; Guo, Z; Li, H; Shao, Q; Sun, L; Wang, C; Wu, L; Yin, X; York, P; Zhang, J | 1 |
| Camacho-Muñoz, D; Kasprzyk-Hordern, B; Thomas, KV | 1 |
| Bellucci, A; Benarese, M; Branca, C; Faggi, L; Imbimbo, BP; Lanzillotta, A; Mota, M; Parrella, E; Pizzi, M; Porrini, V; Sarnico, I; Spano, P | 1 |
| Canotilho, J; Castro, RAE; Eusébio, MES; Machado, SMT; Maria, TMR | 1 |
| Iwaki, M; Kawase, A; Kobayashi, Y; Ogiso, T; Shimada, H; Tanahashi, S | 1 |
| Akpınar, M; Coşkun, BU; Erol, ZN; Kaya, KS; Türk, B; Ünsal, Ö | 1 |
| Ask, KS; Gjelstad, A; Pedersen-Bjergaard, S; Øiestad, EL | 1 |
| Abbas, S; Abbas, SM; Ali, S; Hameed, S; Iqbal, J; Munawar, KS; Rahman, SU; Shaheen, F; Tahir, MN; Zaib, S | 1 |
| Ma, R; Qu, H; Wang, B; Wang, F; Yu, G; Yu, Y | 1 |
| Alshana, U; Hassan, M | 1 |
| Carrasco-Correa, EJ; Giesbers, M; Herrero-Martínez, JM; Simó-Alfonso, EF | 1 |
| Barlow, DJ; Jackson, PJM; Pysz, I; Rahman, KM; Thurston, DE | 1 |
| Glatz, Z; Michalcová, L; Nevídalová, H | 1 |
| Dai, X; Ding, CF; Fang, X; Gu, L; Jiang, Y; Wu, F; Xu, F; Yang, S; Yu, S | 1 |
| Eichhorn, T; Hey-Hawkins, E; Kaluđerović, GN; Morgan, I; Predarska, I; Saoud, M | 1 |
| Chaturvedi, K; Dave, RH; Morris, KR; Shah, HS | 1 |
| Bojkova, D; Charlesworth, B; Ciesek, S; Cinatl, J; de Bruin, N; Gribbon, P; Kannt, A; Laughey, WF; Lodhi, I; Pennick, G; Reus, P; Schiffmann, S; Schneider, AK; Sinclair, S; Talmon, S | 1 |
| Bădulescu, M; Stefan-van Staden, RI; Ţuchiu, BM; van Staden, JF | 1 |
| Du, G; Fang, Z; Gong, N; Lu, Y; Xing, C; Xing, W; Yu, H; Zhang, B | 1 |
| Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC | 1 |
| Habara, M; Haraguchi, T; Ikezaki, H; Kawasaki, I; Kojima, H; Ohkawa, K; Ozeki, M; Uchida, T; Uno, R; Yoshida, M | 1 |
| Abdul Qadir, M; Ahmad, S; Ahmed, M; Ali, I; Imran, M; Muddassar, M; Wani, TA; Yousaf, N; Zargar, S | 1 |
11 review(s) available for ibuprofen and flurbiprofen
| Article | Year |
|---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The propionic acids: a personal perspective.
Topics: Analgesia; Animals; Arthritis, Rheumatoid; Aspirin; Drug Therapy; Flurbiprofen; Humans; Ibuprofen; Phenylacetates; Phenylpropionates; Propionates | 1992 |
Stereoselective metabolism of anti-inflammatory 2-arylpropionates.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Naproxen; Stereoisomerism; Suprofen | 1990 |
Preoperative nonsteroidal anti-inflammatory medication for the prevention of postoperative dental pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Humans; Ibuprofen; Mouth; Pain, Postoperative; Premedication; Tooth Extraction | 1989 |
The propionic acids. Gastrointestinal toxicity in various species.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Digestive System; Dogs; Fenoprofen; Flurbiprofen; Haplorhini; Ibuprofen; Naproxen; Propionates; Rats; Species Specificity | 1988 |
Nonsteroidal antiinflammatory drugs as inhibitors of periodontal disease progression.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Inflammation; Periodontal Diseases; Prostaglandin Antagonists; Prostaglandins | 1993 |
Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods.
Topics: Adrenergic Uptake Inhibitors; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Area Under Curve; Computer Simulation; Disopyramide; Doxepin; Drug Interactions; Flurbiprofen; Food-Drug Interactions; Guidelines as Topic; Hydroxychloroquine; Ibuprofen; Nadolol; Nortriptyline; Propafenone; Stereoisomerism; Therapeutic Equivalency; Verapamil | 1997 |
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Inflammation; Models, Biological; Models, Chemical; Models, Genetic; NF-kappa B; Peptides; Peroxisome Proliferator-Activated Receptors; PPAR gamma; Prostaglandin-Endoperoxide Synthases | 2005 |
[A novel class of anti-inflammatory and analgesic drugs--NO-donating NSAIDs].
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Cyclooxygenase Inhibitors; Flurbiprofen; Gastrointestinal Diseases; Humans; Ibuprofen; Naproxen; Nitrates; Nitric Oxide Donors | 2007 |
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain | 2022 |
10 trial(s) available for ibuprofen and flurbiprofen
| Article | Year |
|---|---|
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Mefenamic Acid; Pain; Phenylacetates; Placebos; Prednisone; Salicylates | 1976 |
Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Patient Compliance; Phenylpropionates; Propionates | 1977 |
Response of osteoarthritis to ibuprofen or flurbiprofen.
Topics: Aged; Clinical Trials as Topic; Drug Evaluation; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; Phenylpropionates; Propionates | 1976 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibuprofen; Inflammation; Male; Methylprednisolone; Molar, Third; Pain, Postoperative; Tooth Extraction; Tooth, Impacted; Trismus; Vertical Dimension | 1990 |
[A double-blind clinical evaluation of flurbiprofen on acute upper respiratory tract inflammation--comparative study with ibuprofen].
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Propionates; Respiratory Tract Infections | 1984 |
The effect of food on the bioavailability of ibuprofen and flurbiprofen from sustained release formulations.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Diet, Vegetarian; Flurbiprofen; Food-Drug Interactions; Humans; Ibuprofen; Male | 1996 |
Pharmacokinetics and pharmacodynamics of enantiomers of ibuprofen and flurbiprofen after oral administration.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Evoked Potentials; Flurbiprofen; Humans; Ibuprofen; Pain Measurement; Placebos; Stereoisomerism | 1997 |
Pain control during fixed orthodontic appliance therapy.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Facial Pain; Female; Flurbiprofen; Humans; Ibuprofen; Male; Naproxen; Orthodontic Appliances; Orthodontics, Corrective; Pain Measurement; Prospective Studies; Surveys and Questionnaires | 2005 |
Albumin-binding of diclofenac and the effect of a site II inhibitor in the aqueous humor of cataract patients with the instillation of diclofenac.
Topics: Administration, Ophthalmic; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Binding Sites; Cataract; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Serum Albumin | 2014 |
The effect of flurbiprofen oral spray and ibuprofen vs ibuprofen alone on postoperative tonsillectomy pain: An open, randomised, controlled trial.
Topics: Adolescent; Adult; Analgesics; Drug Therapy, Combination; Female; Flurbiprofen; Humans; Ibuprofen; Male; Middle Aged; Oral Sprays; Pain, Postoperative; Tonsillectomy; Young Adult | 2018 |
162 other study(ies) available for ibuprofen and flurbiprofen
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis | 1999 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors | 2003 |
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Carboxylic Acids; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Flurbiprofen; Halogens; Ibuprofen; Isoenzymes; Kinetics; Propionates; Prostaglandin-Endoperoxide Synthases; Sheep; Structure-Activity Relationship | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism | 2005 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.
Topics: Acute Disease; Analgesics; Animals; Bacteria; Diphenylacetic Acids; Female; Fungi; Hepatocytes; Ibuprofen; Inflammation; Lipid Peroxidation; Male; Mice; Rats; Thiadiazoles; Triazoles; Ulcer | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Characterization of the drug binding specificity of rat liver fatty acid binding protein.
Topics: Anilino Naphthalenesulfonates; Animals; Fatty Acid-Binding Proteins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Fluorescence; Substrate Specificity | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.
Topics: Fatty Acid-Binding Proteins; Fluorescent Dyes; Humans; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Spectrometry, Fluorescence | 2014 |
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.
Topics: Amidohydrolases; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Flurbiprofen; Humans; Serotonin; TRPV Cation Channels | 2014 |
Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Line, Tumor; Cyclin D1; Cytoskeletal Proteins; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hepatocytes; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinase 5; MCF-7 Cells; Molecular Docking Simulation; Nuclear Proteins; Oxidative Stress; Protein Structure, Secondary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship; Signal Transduction; Thiadiazines; Triazoles | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Allosteric Regulation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chick Embryo; Ibuprofen; Models, Molecular; Protein Conformation; Rats; Structure-Activity Relationship; Xenopus laevis | 2017 |
Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles.
Topics: Antifungal Agents; Candida; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 51; Ergosterol; Fluconazole; Microbial Sensitivity Tests; Stereoisomerism | 2022 |
Flurbiprofen: highly potent inhibitor of prostaglandin synthesis.
Topics: Animals; Arachidonic Acids; Aspirin; Cattle; Cyclooxygenase Inhibitors; Flurbiprofen; Ibuprofen; Indomethacin; Male; Microsomes; Oxygen Consumption; Phenylbutazone; Propionates; Prostaglandins E; Seminal Vesicles | 1978 |
Potentiation of PG effects on the intraocular muscles of the cat by inhibition of PG synthesis.
Topics: Animals; Cats; Ciliary Body; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Flurbiprofen; Ibuprofen; In Vitro Techniques; Indomethacin; Iris; Mixed Function Oxygenases; Muscle Contraction; Muscle, Smooth; Prostaglandins; Prostaglandins E; Prostaglandins F | 1977 |
Further characterization of specific drug binding sites on human serum albumin.
Topics: Binding Sites; Dialysis; Flurbiprofen; Humans; Ibuprofen; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Stearic Acids | 1976 |
In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents.
Topics: Acetaminophen; Acetonitriles; Administration, Oral; Animals; Anti-Inflammatory Agents; Brain; Duodenum; Female; Flurbiprofen; Gastric Mucosa; Ibuprofen; Indomethacin; Intestine, Small; Kidney; Liver; Lung; Prostaglandins E; Prostaglandins F; Radioimmunoassay; Rats; Time Factors | 1976 |
Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage.
Topics: Aged; Aging; Anti-Inflammatory Agents; Cartilage, Articular; Depression, Chemical; Flurbiprofen; Glycosaminoglycans; Humans; Hydrocortisone; Ibuprofen; In Vitro Techniques; Indomethacin; Middle Aged; Sodium Salicylate | 1976 |
Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Fatty Acids; Flurbiprofen; Ibuprofen; Indomethacin; Kinetics; Meclofenamic Acid; Mefenamic Acid; Oxygen Consumption; Oxygenases; Prostaglandins; Structure-Activity Relationship | 1975 |
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Guinea Pigs; Ibuprofen; Male; Mice; Propionates; Rats; Serum Albumin | 1975 |
Pulmonary inversion of 2-arylpropionic acids: influence of protein binding.
Topics: Animals; Chromatography, High Pressure Liquid; Fenoprofen; Flurbiprofen; Ibuprofen; In Vitro Techniques; Lung; Male; Molecular Conformation; Protein Binding; Rabbits; Serum Albumin, Bovine; Stereoisomerism | 1992 |
Evidence of multiple forms of rat liver microsomal coenzyme A ligase catalysing the formation of 2-arylpropionyl-coenzyme A thioesters.
Topics: Animals; Coenzyme A Ligases; Esters; Flurbiprofen; Ibuprofen; Isoenzymes; Microsomes, Liver; Rats; Stereoisomerism; Sulfhydryl Compounds; Thiolester Hydrolases | 1992 |
Stereoselective enzymatic hydrolysis of various ester prodrugs of ibuprofen and flurbiprofen in human plasma.
Topics: Esters; Flurbiprofen; Humans; Hydrolysis; Ibuprofen; Prodrugs | 1992 |
Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Rats; Species Specificity; Stereoisomerism; Tumor Cells, Cultured | 1992 |
The effect of the enantiomers of ibuprofen and flurbiprofen on the beta-oxidation of palmitate in the rat.
Topics: Animals; Carbon Dioxide; Flurbiprofen; Ibuprofen; Male; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Rats; Rats, Inbred Strains; Stereoisomerism | 1992 |
Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss.
Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Flurbiprofen; Gingival Crevicular Fluid; Ibuprofen; Naproxen; Prostaglandins F; Thromboxane B2 | 1992 |
Antimicrobial activity of flurbiprofen and ibuprofen in vitro against six common periodontal pathogens.
Topics: Aggregatibacter actinomycetemcomitans; Bacteroides; Eikenella corrodens; Flurbiprofen; Fusobacterium nucleatum; Gram-Negative Bacteria; Ibuprofen; Periodontal Diseases; Wolinella | 1991 |
Flurbiprofen-associated acute tubulointerstitial nephritis.
Topics: Adult; Biopsy; Flurbiprofen; Humans; Ibuprofen; Kidney; Male; Nephritis, Interstitial; Pain | 1991 |
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents.
Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Eicosapentaenoic Acid; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Meclofenamic Acid; Naproxen; Periodontitis; Periodontium; Vitamin E | 1990 |
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Flurbiprofen; Humans; Ibuprofen; Injections, Intramuscular; Male; Methotrexate; Middle Aged | 1990 |
Stereoselective disposition of ibuprofen and flurbiprofen in rats.
Topics: Animals; Flurbiprofen; Ibuprofen; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
The effects of topical S(+)-ibuprofen on interleukin-1 induced ocular inflammation in a rabbit model.
Topics: Administration, Topical; Animals; Aqueous Humor; Capillary Permeability; Cell Count; Disease Models, Animal; Eye Proteins; Female; Flurbiprofen; Ibuprofen; Interleukin-1; Male; Prednisolone; Rabbits; Uveitis | 1990 |
Stereoselective arylpropionyl-CoA thioester formation in vitro.
Topics: Acyl Coenzyme A; Animals; Coenzyme A; Coenzyme A Ligases; Fenoprofen; Flurbiprofen; Ibuprofen; In Vitro Techniques; Male; Protein Binding; Pseudomonas; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Serum Albumin, Bovine; Stereoisomerism; Subcellular Fractions; Substrate Specificity | 1990 |
Ibuprofen poisoning in dogs.
Topics: Animals; Dog Diseases; Dogs; Flurbiprofen; Ibuprofen | 1989 |
Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs--1. In vitro studies of ibuprofen and flurbiprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Intestine, Small; Isomerism; Kidney; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1989 |
Chromatographic approaches to the quality control of chiral propionate anti-inflammatory drugs and herbicides.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Chromatography, Gas; Flurbiprofen; Herbicides; Ibuprofen; Ketoprofen; Quality Control; Stereoisomerism | 1989 |
Metabolic chiral inversion of anti-inflammatory 2-arylpropionates: lack of reaction in liver homogenates, and study of methine proton acidity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Guinea Pigs; Ibuprofen; Isomerism; Kinetics; Liver; Male; Naproxen; Protons; Rats; Rats, Inbred Strains; Suprofen | 1988 |
Absorption through human skin of ibuprofen and flurbiprofen; effect of dose variation, deposited drug films, occlusion and the penetration enhancer N-methyl-2-pyrrolidone.
Topics: Acetone; Aged; Aspirin; Diffusion; Dose-Response Relationship, Drug; Female; Flurbiprofen; Humans; Ibuprofen; In Vitro Techniques; Male; Middle Aged; Permeability; Propionates; Pyrrolidinones; Skin Absorption | 1985 |
Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2.
Topics: Animals; Antineoplastic Agents; Cyclooxygenase Inhibitors; Dinoprostone; Female; Flurbiprofen; Ibuprofen; Immunization; Indomethacin; Mammary Neoplasms, Experimental; Prostaglandins E; Rats; Rats, Inbred F344 | 1986 |
Modulation of arachidonic acid metabolism in experimental arthritis induced by Salmonella enteritidis. I. Effect of ibuprofen and flurbiprofen on experimental arthritis induced by Salmonella enteritidis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Infectious; Flurbiprofen; Ibuprofen; Male; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salmonella enteritidis; Salmonella Infections | 1987 |
Cell damage unmasks 15-lipoxygenase activity in human neutrophils.
Topics: Acetates; Arachidonate Lipoxygenases; Aspirin; Dose-Response Relationship, Drug; Etodolac; Fluorometry; Flurbiprofen; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; L-Lactate Dehydrogenase; Lipoxygenase; Naproxen; Neutrophils; Phenylbutazone | 1985 |
Differential in vivo effects of indomethacin, ibuprofen, and flurbiprofen on oxygen-dependent killing activities of neutrophils elicited by acute nonimmune inflammation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Indomethacin; Inflammation; Male; Neutrophils; Oxygen; Phagocytosis; Rats; Rats, Inbred Strains | 1988 |
A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Flurbiprofen; Gluconeogenesis; Ibuprofen; Kinetics; Liver; Male; Phenylbutyrates; Propionates; Rats; Rats, Inbred Strains; Serum Albumin; Structure-Activity Relationship; Urea | 1988 |
Relationships between thromboxane production, platelet aggregability, and serum concentrations of ibuprofen or flurbiprofen.
Topics: Adult; Flurbiprofen; Humans; Ibuprofen; Platelet Aggregation; Propionates; Thromboxanes | 1987 |
Pharmacological studies of antigen-induced arthritis in BALB/c mice. I. Characterization of the arthritis and the effects of steroidal and non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Dexamethasone; Female; Flurbiprofen; Ibuprofen; Indomethacin; Joints; Leukocyte Count; Lymphocytes; Mice; Mice, Inbred BALB C; Monocytes; Neutrophils; Prednisolone; Time Factors | 1986 |
Adhesion formation and uterine tube healing in the rabbit: a controlled study of the effect of ibuprofen and flurbiprofen.
Topics: Animals; Fallopian Tube Diseases; Fallopian Tubes; Female; Flurbiprofen; Ibuprofen; Postoperative Care; Postoperative Complications; Preoperative Care; Propionates; Rabbits; Sterilization Reversal; Tissue Adhesions; Wound Healing | 1986 |
Rapid HPLC-determination of ibuprofen and flurbiprofen in plasma for therapeutic drug control and pharmacokinetic applications.
Topics: Adult; Chromatography, High Pressure Liquid; Flurbiprofen; Half-Life; Humans; Ibuprofen; Kinetics; Male; Propionates | 1986 |
In vivo modulation of leukotaxis by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Chemotaxis, Leukocyte; Female; Flurbiprofen; Ibuprofen; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Rabbits | 1985 |
Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2.
Topics: Adenocarcinoma; Animals; Antibodies; Antineoplastic Agents; Cell Line; Cyclooxygenase Inhibitors; Dinoprostone; Female; Flurbiprofen; Ibuprofen; Immunotherapy; Indomethacin; Mammary Neoplasms, Experimental; Propionates; Prostaglandins E; Rats; Rats, Inbred F344 | 1985 |
European experience with flurbiprofen. A new analgesic/anti-inflammatory agent.
Topics: Aspirin; Drug Evaluation; Europe; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Propionates | 1986 |
Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Female; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Recurrence; Salicylates | 1981 |
Experimentally induced heterotopic ossification in rats influenced by anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Bone Matrix; Calcium Radioisotopes; Flurbiprofen; Ibuprofen; Male; Ossification, Heterotopic; Propionates; Rats; Rats, Inbred Strains | 1983 |
In vivo interaction of nonsteroidal anti-inflammatory drugs on the locomotion of neutrophils elicited by acute non-specific inflammations in the rat--effect of indomethacin, ibuprofen and flurbiprofen.
Topics: Animals; Anti-Inflammatory Agents; Blood; Calcium Pyrophosphate; Chemotaxis, Leukocyte; Flurbiprofen; Ibuprofen; In Vitro Techniques; Indomethacin; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pleurisy; Rats; Rats, Inbred Strains | 1984 |
Tetrazole analogues of ibuprofen and flurbiprofen.
Topics: Analgesics; Animals; Azoles; Flurbiprofen; Ibuprofen; Male; Mice; Propionates; Tetrazoles | 1983 |
Tolerability of ibuprofen and flurbiprofen in G-6-PD deficient subjects: in vitro study.
Topics: Erythrocytes; Female; Flurbiprofen; Glutathione; Glycogen Storage Disease Type I; Humans; Ibuprofen; Male; Propionates | 1981 |
Dependency of location of salvageable myocardium on type of intervention.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Flurbiprofen; Glycine; Heart; Ibuprofen; Male; Myocardial Infarction; Myocardium; Necrosis; Risk | 1981 |
Determination of flurbiprofen and ibuprofen in dog serum with automated sample preparation.
Topics: Animals; Autoanalysis; Chromatography, High Pressure Liquid; Dogs; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Propionates | 1981 |
Lysosomal stabilizing effects of two non-steroidal anti-inflammatory agents in the hypoxic liver.
Topics: Animals; Anti-Inflammatory Agents; Cats; Female; Flurbiprofen; Ibuprofen; L-Lactate Dehydrogenase; Liver; Lysosomes; Male; Oxygen; Time Factors | 1980 |
Effects of flurbiprofen on myocardial cell damage in acute myocardial ischemia.
Topics: Acute Disease; Animals; Blood Pressure; Cats; Cell Membrane; Coronary Disease; Creatine Kinase; Electrocardiography; Flurbiprofen; Heart; Heart Rate; Ibuprofen; Lysosomes; Male; Oxygenases; Platelet Aggregation; Propionates; Thromboxane A2; Vascular Resistance | 1980 |
The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis.
Topics: Animals; Bone Resorption; Breast Neoplasms; Culture Techniques; Diphosphonates; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Mice; Neoplasms, Experimental; Osteolysis; Prostaglandin Antagonists | 1980 |
Alterations in the electroretinogram of newborn piglets by propionic acid-derivative nonsteroidal antiinflammatory drugs but not by indomethacin and diclofenac.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electroretinography; Flurbiprofen; Ibuprofen; Indomethacin; Naproxen; Photoreceptor Cells; Propionates; Prostaglandins; Retina; Swine | 1995 |
Induction of transcription factors in human T lymphocytes by aspirin-like drugs.
Topics: Adult; Base Sequence; Benzoquinones; Calcium; Cell Nucleus; Diclofenac; DNA-Binding Proteins; Female; Flurbiprofen; Gene Expression Regulation; Humans; Ibuprofen; Interleukin-2; Isoenzymes; Lactams, Macrocyclic; Lymphocyte Activation; Male; Middle Aged; Molecular Sequence Data; Muromonab-CD3; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Type C Phospholipases | 1995 |
Dermatitis herpetiformis induced by nonsteroidal anti-inflammatory drugs.
Topics: Adult; Dermatitis Herpetiformis; Flurbiprofen; Humans; Ibuprofen; Immunoglobulin A; Keratinocytes; Male; Neutrophils | 1994 |
Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Cell Count; Culture Media; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Liver Neoplasms; Liver Neoplasms, Experimental; Propionates; Rats; Species Specificity; Stereoisomerism; Tumor Cells, Cultured | 1993 |
Stereoselectivity of biliary excretion of 2-arylpropionates in rats.
Topics: Animals; Bile; Flurbiprofen; Ibuprofen; Injections, Intravenous; Ketoprofen; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1993 |
Induction of peroxisomal beta-oxidation by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Clofibric Acid; Dose-Response Relationship, Drug; Flurbiprofen; Ibuprofen; Liver; Male; Microbodies; Oxidation-Reduction; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship; Triglycerides | 1993 |
Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Arginine; Base Sequence; Binding Sites; Cyclooxygenase Inhibitors; DNA Primers; Enzyme Inhibitors; Flurbiprofen; Glutamates; Ibuprofen; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylpropionates; Prostaglandin-Endoperoxide Synthases; Protein Structure, Tertiary; Sheep; Structure-Activity Relationship; Tyrosine | 1996 |
Clofibric acid increases the undirectional chiral inversion of ibuprofen in rat liver preparations.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clofibric Acid; Coenzyme A; Drug Interactions; Flurbiprofen; Hypolipidemic Agents; Ibuprofen; Kinetics; Liver; Male; Perfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1996 |
Effect of the enantiomers of flurbiprofen, ibuprofen, and ketoprofen on intestinal permeability.
Topics: Animals; Dose-Response Relationship, Drug; Flurbiprofen; Ibuprofen; Intestinal Absorption; Ketoprofen; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1996 |
Effect of concentration, pH, and preservative on in vitro transcorneal permeation of ibuprofen and flurbiprofen from non-buffered aqueous drops.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Cornea; Flurbiprofen; Goats; Hydrogen-Ion Concentration; Ibuprofen; Ophthalmic Solutions; Permeability; Preservatives, Pharmaceutical; Water | 1997 |
Effects of non-steroidal anti-inflammatory drugs and cyclooxygenase-2 specific inhibitors on mediator release from rat peritoneal mast cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Activation; Flurbiprofen; Histamine Release; Ibuprofen; Immunoglobulin E; Indans; Indomethacin; Isoenzymes; Male; Mast Cells; Naphthaleneacetic Acids; Nitrobenzenes; Peritoneal Cavity; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1998 |
Effect of chemical structure on the release of certain propionic acid derivatives from their dosage forms.
Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Dosage Forms; Drug Compounding; Drug Stability; Drug Storage; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Molecular Structure; Naproxen; Propionates; Suppositories | 1998 |
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
Topics: Aging; Animals; Arachidonic Acids; Brain; Cell Extracts; Cell Survival; Dose-Response Relationship, Drug; Endocannabinoids; Flurbiprofen; Glioma; Hydrolysis; Ibuprofen; Inhibitory Concentration 50; Ketorolac; Kinetics; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors; Tolmetin; Tumor Cells, Cultured | 1999 |
Stereoselective and substrate-dependent inhibition of hepatic mitochondria beta-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coenzyme A; Flurbiprofen; Ibuprofen; Ketorolac; Lipid Metabolism; Male; Mitochondria, Liver; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Palmitic Acid; Rats; Rats, Wistar; Stereoisomerism; Tolmetin | 1999 |
Direct enantiomeric resolution of some 2-arylpropionic acids using (-)-brucine-impregnated thin-layer chromatography.
Topics: Chromatography, Thin Layer; Flurbiprofen; Ibuprofen; Stereoisomerism; Strychnine | 1999 |
R- and S-isomers of nonsteroidal anti-inflammatory drugs differentially regulate cytokine production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dinoprostone; Female; Flurbiprofen; Ibuprofen; In Vitro Techniques; Interleukin-10; Interleukin-6; Ketoprofen; Lipopolysaccharides; Macrophages, Peritoneal; Mice; RNA, Messenger; Stereoisomerism; Tumor Necrosis Factor-alpha | 2000 |
Directed control of electroosmotic flow in nonaqueous electrolytes using poly(ethylene glycol) coated capillaries.
Topics: Acetonitriles; Benzoic Acid; Buffers; Chemical Phenomena; Chemistry, Physical; Electrolytes; Electrophoresis, Capillary; Flurbiprofen; Ibuprofen; Methanol; Osmosis; Phenylacetates; Polyethylene Glycols; Propionates; Reproducibility of Results; Salicylic Acid; Silicon Dioxide; Solvents; Sulindac; Surface Properties; Water | 2001 |
Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Catalysis; Crystallization; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Enzyme Activation; Flurbiprofen; Ibuprofen; Isoenzymes; Kinetics; Male; Phenylacetates; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protein Conformation; Sheep; Structure-Activity Relationship | 2001 |
Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Celecoxib; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Flurbiprofen; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Ibuprofen; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Nitric Oxide; Presenilin-1; Pyrazoles; Sulfonamides; Treatment Outcome | 2002 |
Identification of drug-binding sites on human serum albumin using affinity capillary electrophoresis and chemically modified proteins as buffer additives.
Topics: 2-Hydroxy-5-nitrobenzyl Bromide; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Buffers; Chemical Warfare Agents; Dextrans; Electrophoresis, Capillary; Flurbiprofen; Humans; Ibuprofen; Molecular Structure; Serum Albumin; Suprofen; Tetranitromethane; Tryptophan; Warfarin | 2002 |
The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle; Cell Division; Diclofenac; Fibrosarcoma; Flurbiprofen; Ibuprofen; In Vitro Techniques; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Survival Rate; Tumor Cells, Cultured | 2002 |
Selective inhibition of Abeta42 production by NSAID R-enantiomers.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Ibuprofen; Kidney; Mutation; NF-kappa B; Peptide Fragments; Peptides; Stereoisomerism; Transfection | 2002 |
Enhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclodextrins; Electrophoresis, Capillary; Fenoprofen; Flurbiprofen; Ibuprofen; Ketoprofen; Static Electricity; Stereoisomerism | 2003 |
Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Endocannabinoids; Extracellular Space; Flurbiprofen; Glioma; Hydrogen-Ion Concentration; Hydrolysis; Ibuprofen; Intracellular Space; Polyunsaturated Alkamides; Rats; Stereoisomerism; Time Factors; Tumor Cells, Cultured | 2003 |
Modeling of adhesion in tablet compression--I. Atomic force microscopy and molecular simulation.
Topics: Adhesiveness; Chemistry, Pharmaceutical; Compressive Strength; Drug Compounding; Flurbiprofen; Ibuprofen; Iron; Ketoprofen; Microscopy, Atomic Force; Models, Molecular; Surface Properties; Tablets; X-Ray Diffraction | 2003 |
Simultaneous chiral discrimination of multiple profens by cyclodextrin-modified capillary electrophoresis in normal and reversed polarity modes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclodextrins; Electrophoresis, Capillary; Flurbiprofen; Hexadimethrine Bromide; Ibuprofen; Ketoprofen; Phenylpropionates; Stereoisomerism | 2003 |
Modeling of adhesion in tablet compression. II. Compaction studies using a compaction simulator and an instrumented tablet press.
Topics: Adhesiveness; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Drug Compounding; Flurbiprofen; Ibuprofen; Ketoprofen; Lubrication; Pressure; Surface Properties; Tablets | 2004 |
Investigation of the release test method for the topical application of pharmaceutical preparations: release test of cataplasm including nonsteroidal anti-inflammatory drugs using artificial sweat.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Kinetics; Solubility; Sweat; Tablets | 2004 |
Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cholestasis; Diclofenac; Drug Therapy, Combination; Female; Flurbiprofen; Hepatocytes; Humans; Ibuprofen; Ketoprofen; Liver; Male; Meloxicam; Middle Aged; Niflumic Acid; Primary Health Care; Salicylates; Sex Distribution; Statistics, Nonparametric; Thiazines; Thiazoles; Time Factors | 2004 |
S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Culture Media, Conditioned; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Ibuprofen; Microglia; Monocytes; Neuroblastoma; Neurons; Stereoisomerism | 2004 |
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flurbiprofen; Ibuprofen; Isoenzymes; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thrombosis | 2004 |
Separation strategy for acidic chiral pharmaceuticals with capillary electrochromatography on polysaccharide stationary phases.
Topics: Acetonitriles; Buffers; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Flurbiprofen; Hexobarbital; Hydrogen-Ion Concentration; Ibuprofen; Pharmaceutical Preparations; Polysaccharides; Stereoisomerism; Temperature; Warfarin | 2005 |
Determination of ibuprofen and flurbiprofen in pharmaceuticals by capillary zone electrophoresis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Electrophoresis, Capillary; Flurbiprofen; Ibuprofen; Pharmaceutical Preparations; Reproducibility of Results; Stereoisomerism; Tablets | 2006 |
Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Biological Transport; Blood-Brain Barrier; Brain; Capillary Permeability; Flurbiprofen; Ibuprofen; Indomethacin; Kinetics; Male; Perfusion; Protein Binding; Rats; Rats, Wistar; Serum Albumin, Bovine | 2006 |
Factors affecting the formation of eutectic solid dispersions and their dissolution behavior.
Topics: Drug Carriers; Fenofibrate; Flurbiprofen; Griseofulvin; Ibuprofen; Models, Chemical; Molecular Weight; Naproxen; Polyethylene Glycols; Sodium Dodecyl Sulfate; Solubility; Transition Temperature; Water | 2007 |
Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Male; Naproxen; Propionates; Rats; Stomach Ulcer; Structure-Activity Relationship; Thiadiazoles; Thiazoles | 2007 |
The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Ibuprofen; Male; Nerve Tissue Proteins; Prostatic Neoplasms; Receptors, Nerve Growth Factor; RNA, Small Interfering; Transfection; Up-Regulation | 2007 |
The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Eukaryotic Initiation Factor-4E; Flurbiprofen; Humans; Ibuprofen; Immunoblotting; Immunoprecipitation; Luciferases; Male; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Receptors, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Small Interfering; Signal Transduction; Tumor Cells, Cultured | 2007 |
Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner.
Topics: Aspirin; Caveolin 1; Celecoxib; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fibroblasts; Flurbiprofen; Humans; Ibuprofen; Kinetics; Models, Biological; NF-kappa B; Nitrobenzenes; Pyrazoles; Reactive Oxygen Species; Skin; Skin Aging; Sulfonamides; Tumor Suppressor Protein p53 | 2008 |
Tarenflurbil protection from cytotoxicity is associated with an upregulation of neurotrophins.
Topics: Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain-Derived Neurotrophic Factor; Cell Line; Cell Survival; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flurbiprofen; Hydrogen Peroxide; Ibuprofen; Nerve Growth Factors; Neurons; Oxidants; Reverse Transcriptase Polymerase Chain Reaction; RNA; Up-Regulation | 2008 |
CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cyclopropanes; Flurbiprofen; Humans; Ibuprofen; Learning Disabilities; Memory; Mice; Mice, Transgenic; Microglia; Mutation; Peptide Fragments; Plaque, Amyloid | 2009 |
Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carbon Isotopes; Crystallization; Drug Stability; Flurbiprofen; Hot Temperature; Humidity; Hydrogen Bonding; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Structure; Molecular Weight; Naproxen; Phase Transition; Phenylbutyrates; Polymers; Povidone; Static Electricity; X-Ray Diffraction | 2009 |
Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.
Topics: Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Blotting, Western; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclooxygenase 2; Cyclopropanes; Cytoskeleton; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flurbiprofen; Ibuprofen; Immunohistochemistry; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction | 2010 |
Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Dinoprostone; Dose-Response Relationship, Drug; Female; Flurbiprofen; Humans; Ibuprofen; Leukocytes; Male; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2010 |
NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Movement; Flurbiprofen; Growth Differentiation Factor 15; Humans; Ibuprofen; Imidazoles; Male; MAP Kinase Signaling System; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Pyridines; Receptors, Nerve Growth Factor; RNA, Small Interfering; Transforming Growth Factor beta1 | 2010 |
The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cells, Cultured; Cyclooxygenase Inhibitors; Cyclopropanes; Diet; Disease Models, Animal; Flurbiprofen; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Ibuprofen; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Phosphorylation; Signal Transduction; tau Proteins | 2011 |
Lack of enantiomeric influence on the brain cytoprotective effect of ibuprofen and flurbiprofen.
Topics: Animals; Brain; Cyclooxygenase Inhibitors; Cytokines; Cytoprotection; Dinoprostone; Flurbiprofen; Hypoxia, Brain; Ibuprofen; In Vitro Techniques; Lipid Peroxidation; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stereoisomerism; Tyrosine | 2011 |
Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Humans; Ibuprofen; Inhibitory Concentration 50; Naproxen; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Stereoisomerism; Xenopus laevis | 2011 |
Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by cocrystallization with nicotinamide.
Topics: Analgesics; Calorimetry, Differential Scanning; Crystallization; Flurbiprofen; Ibuprofen; Models, Molecular; Niacinamide; Powder Diffraction; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; Vitamin B Complex; Wettability; X-Ray Diffraction | 2012 |
Enantiomeric resolution of ibuprofen and flurbiprofen in human plasma by SPE-chiral HPLC methods.
Topics: Analgesics; Chromatography, High Pressure Liquid; Flurbiprofen; Humans; Ibuprofen; Sensitivity and Specificity; Solid Phase Extraction; Stereoisomerism | 2012 |
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin | 2012 |
In vitro investigations of α-amylase mediated hydrolysis of cyclodextrins in the presence of ibuprofen, flurbiprofen, or benzo[a]pyrene.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; alpha-Amylases; alpha-Cyclodextrins; Animals; Benzo(a)pyrene; beta-Cyclodextrins; Drug Stability; Flurbiprofen; gamma-Cyclodextrins; Hydrolysis; Ibuprofen; Kinetics; Pancreas; Solubility; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Swine | 2012 |
Sensing chiral drugs by using CdSe/ZnS nanoparticles capped with N-acetyl-L-cysteine methyl ester.
Topics: Acetylcysteine; Cadmium Compounds; Circular Dichroism; Esters; Flurbiprofen; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Quantum Dots; Selenium Compounds; Spectrometry, Fluorescence; Stereoisomerism; Sulfides; Zinc Compounds | 2013 |
Separation efficiency of dual-selector systems in capillary electrophoresis.
Topics: Electrophoresis, Capillary; Flurbiprofen; Ibuprofen; Stereoisomerism | 2014 |
Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen.
Topics: Animals; Brain; Cyclooxygenase Inhibitors; Endocannabinoids; Flurbiprofen; Ibuprofen; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2014 |
Determination of thermodynamic values of acidic dissociation constants and complexation constants of profens and their utilization for optimization of separation conditions by Simul 5 Complex.
Topics: Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Computer Simulation; Electrophoresis, Capillary; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Naproxen; Osmolar Concentration; Software; Thermodynamics; Viscosity | 2014 |
Marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes.
Topics: Arachidonate 5-Lipoxygenase; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Flurbiprofen; Ibuprofen; Lipoxygenase Inhibitors; Molecular Structure; Naproxen; Propionates; Structure-Activity Relationship | 2015 |
Parallel artificial liquid membrane extraction of acidic drugs from human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Diclofenac; Equipment Design; Flurbiprofen; Gemfibrozil; Humans; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Liquid-Liquid Extraction; Membranes, Artificial; Pharmaceutical Preparations; Polypropylenes; Polyvinyls | 2015 |
[[Chiral separation of five arylpropionic acid drugs and determination of their enantiomers in pharmaceutical preparations by reversed-phase high performance liquid chromatography with cellulose-tris-(4-methylbenzoate) stationary phase]].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzopyrans; Cellulose; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Flurbiprofen; Ibuprofen; Naproxen; Phenylpropionates; Propionates; Stereoisomerism | 2014 |
Cyclosporin A-sensitive cytotoxicity of flurbiprofen non-stereoselectively mediated by cytochrome P450 metabolism in three-dimensional cultured rat hepatocytes.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochrome P-450 Enzyme System; Flurbiprofen; Hepatocytes; Ibuprofen; L-Lactate Dehydrogenase; Male; Mitochondria; Naproxen; Phenylpropionates; Rats; Rats, Wistar; Stereoisomerism | 2015 |
Do Different Cyclooxygenase Inhibitors Impair Rotator Cuff Healing in a Rabbit Model?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Celecoxib; Cyclooxygenase 2 Inhibitors; Flurbiprofen; Ibuprofen; Male; Rabbits; Rotator Cuff; Tendon Injuries; Wound Healing | 2015 |
Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.
Topics: Amidohydrolases; Aminopyridines; Animals; Brain; Cyclooxygenase Inhibitors; Drug Design; Flurbiprofen; HeLa Cells; Humans; Hydrolysis; Ibuprofen; Inhibitory Concentration 50; Kinetics; Male; Mice; Molecular Dynamics Simulation; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Stereoisomerism | 2015 |
Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations.
Topics: beta-Cyclodextrins; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Kinetics; Ligands; Macromolecular Substances; Pyronine; Thermodynamics | 2016 |
Enantioselective simultaneous analysis of selected pharmaceuticals in environmental samples by ultrahigh performance supercritical fluid based chromatography tandem mass spectrometry.
Topics: Aminorex; Carbazoles; Chloramphenicol; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Flurbiprofen; Humans; Ibuprofen; Ifosfamide; Imidazoles; Indoprofen; Molecular Structure; Naproxen; Ofloxacin; Omeprazole; Praziquantel; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry; Tetramisole; Water Pollutants, Chemical | 2016 |
Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation.
Topics: Animals; Apoptosis; Caspase 3; Cell Nucleus; Cerebral Cortex; Cyclopropanes; Cytochromes c; Enzyme Activation; Flurbiprofen; Glucose; Glycogen Synthase Kinase 3 beta; Ibuprofen; Mice, Inbred C57BL; Necrosis; Neurons; Neuroprotective Agents; Oxygen; p38 Mitogen-Activated Protein Kinases; Transcription Factor RelA | 2017 |
Levetiracetam+nonsteroidal anti-inflammatory drug binary systems: A contribution to the development of new solid dosage forms.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Combinations; Drug Liberation; Flurbiprofen; Ibuprofen; Ketoprofen; Levetiracetam; Naproxen; Piracetam; Stereoisomerism | 2017 |
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Flurbiprofen; Glucuronides; Ibuprofen; Ketoprofen; Male; Microsomes, Liver; Naproxen; Propionates; Protein Binding; Rats, Wistar | 2018 |
Dried blood spots and parallel artificial liquid membrane extraction-A simple combination of microsampling and microextraction.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Fenoprofen; Flurbiprofen; Healthy Volunteers; Humans; Ibuprofen; Ketoprofen; Liquid-Liquid Extraction; Membranes, Artificial; Quetiapine Fumarate; Tandem Mass Spectrometry | 2018 |
Carbonic Anhydrase Inhibitory Potential of 1,2,4-triazole-3-thione Derivatives of Flurbiprofen, Ibuprofen and 4-tert-butylbenzoic Hydrazide: Design, Synthesis, Characterization, Biochemical Evaluation, Molecular Docking and Dynamic Simulation Studies.
Topics: Benzoates; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Flurbiprofen; Ibuprofen; Molecular Docking Simulation; Schiff Bases; Spectrum Analysis; Structure-Activity Relationship; Triazoles | 2019 |
Simultaneous enantiomeric analysis of non-steroidal anti-inflammatory drugs in environment by chiral LC-MS/MS: A pilot study in Beijing, China.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Beijing; Chromatography, High Pressure Liquid; Environmental Monitoring; Flurbiprofen; Ibuprofen; Naproxen; Pilot Projects; Rivers; Stereoisomerism; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2019 |
Switchable-hydrophilicity solvent liquid-liquid microextraction of non-steroidal anti-inflammatory drugs from biological fluids prior to HPLC-DAD determination.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Centrifugation; Chromatography, High Pressure Liquid; Etodolac; Flurbiprofen; Humans; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Ketoprofen; Linear Models; Liquid Phase Microextraction; Milk, Human; Organic Chemicals; Reproducibility of Results; Saliva; Sodium Hydroxide; Solvents | 2019 |
Hybrid monoliths with metal-organic frameworks in spin columns for extraction of non-steroidal drugs prior to their quantitation by reversed-phase HPLC.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Limit of Detection; Metal-Organic Frameworks; Methylmethacrylates; Solid Phase Microextraction | 2019 |
UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads.
Topics: Biological Assay; Calicheamicins; Chromatography, High Pressure Liquid; Doxorubicin; Flurbiprofen; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Immunoconjugates; Irinotecan; Ketoprofen; Maytansine; Molecular Conformation; Norfloxacin; Pentachlorophenol; Protein Multimerization; Structure-Activity Relationship; Tandem Mass Spectrometry; Tolnaftate | 2020 |
Applicability of capillary electrophoresis-frontal analysis for displacement studies: Effect of several drugs on l-tryptophan and lidocaine binding to human serum albumin.
Topics: Binding Sites; Chlorpropamide; Diclofenac; Electrophoresis, Capillary; Flurbiprofen; Humans; Ibuprofen; Lidocaine; Phenylbutazone; Serum Albumin, Human; Tolbutamide; Tryptophan | 2020 |
Direct distinction of ibuprofen and flurbiprofen enantiomers by ion mobility mass spectrometry of their ternary complexes with metal cations and cyclodextrins in the gas phase.
Topics: Calcium; Cations; Coordination Complexes; Cyclodextrins; Flurbiprofen; Ibuprofen; Ion Mobility Spectrometry; Lithium; Molecular Structure; Sodium; Stereoisomerism | 2021 |
Cisplatin-cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Humans; Ibuprofen; Molecular Structure; Naproxen; Platinum; Silicon Dioxide | 2022 |
Modeling of Adhesion in Tablet Compression at the Molecular Level Using Thermal Analysis and Molecular Simulations.
Topics: Adhesiveness; Calorimetry, Differential Scanning; Compressive Strength; Flurbiprofen; Ibuprofen; Ketoprofen; Models, Molecular; Tablets | 2022 |
Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.
Topics: Acetaminophen; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; COVID-19; Disease Progression; Enzyme Activation; Etoricoxib; Flurbiprofen; Gene Expression Regulation, Enzymologic; Humans; Ibuprofen; Male; Mice; Mice, Inbred C57BL; SARS-CoV-2; Virus Internalization | 2022 |
Disposable stochastic sensors for fast analysis of ibuprofen, ketoprofen, and flurbiprofen in their topical pharmaceutical formulations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbon; Copper; Drug Compounding; Flurbiprofen; Ibuprofen; Ketoprofen | 2022 |
An Evolving Role of Aqueous Piperazine to Improve the Solubility of Non-Steroidal Anti-Inflammatory Drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Flurbiprofen; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutazone; Piperazine; Powders; Salts; Solubility; Spectroscopy, Fourier Transform Infrared; Sulindac; Water; X-Ray Diffraction | 2022 |
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Famotidine; Flurbiprofen; Ibuprofen; Naproxen; Taste | 2023 |
New Acetamide-Sulfonamide-Containing Scaffolds: Antiurease Activity Screening, Structure-Activity Relationship, Kinetics Mechanism, Molecular Docking, and MD Simulation Studies.
Topics: Canavalia; Enzyme Inhibitors; Flurbiprofen; Ibuprofen; Kinetics; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Sulfacetamide; Sulfamerazine; Sulfanilamide; Sulfonamides; Urease | 2023 |