ibuprofen and celecoxib

ibuprofen has been researched along with celecoxib in 206 studies

Research

Studies (206)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (1.94)18.2507
2000's81 (39.32)29.6817
2010's109 (52.91)24.3611
2020's12 (5.83)2.80

Authors

AuthorsStudies
Habeeb, AG; Knaus, EE; Praveen Rao, PN1
Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N1
Amini, M; Habeeb, AG; Knaus, EE; Li, H; Praveen Rao, PN1
Knaus, EE; Rao, PN; Uddin, MJ1
Chakraborti, AK; Jachak, SM; Selvam, C; Thilagavathi, R1
Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Anderluh, M; Brunskole, M; Gobec, S; Lanisnik Rizner, T; Stefane, B; Stojan, J; Zorko, K1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Abdellatif, KR; Chowdhury, MA; Das, D; Dong, Y; Knaus, EE; Suresh, MR; Velázquez, C1
Abdellatif, KR; Chowdhury, MA; Das, D; Dong, Y; Knaus, EE; Rahman, M; Suresh, MR1
Abdellatif, KR; Chowdhury, MA; Das, D; Dong, Y; Knaus, EE; Suresh, MR1
Abdellatif, KR; Chowdhury, MA; Das, D; Dong, Y; Knaus, EE; Suresh, MR; Velázquez, C; Yu, G1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Abdellatif, KR; Chowdhury, MA; Das, D; Dong, Y; Huang, Z; Knaus, EE; Rahman, M; Suresh, MR; Velázquez, CA; Yu, G1
Abdellatif, KR; Chowdhury, MA; Das, D; Dong, Y; Huang, Z; Knaus, EE; Suresh, MR; Velázquez, CA; Yu, G1
Ekins, S; Williams, AJ; Xu, JJ1
Bensdorf, K; Guo, C; Gust, R; Huang, W; Liu, H; Liu, W; Qian, H; Rubner, G; Wang, Y; Wellner, A; Zhang, H; Zhang, Y; Zhou, J1
Abdellatif, KR; Chowdhury, MA; Huang, Z; Kaufman, S; Knaus, EE1
Abdur Rahim, M; Bhardwaj, A; Huang, Z; Kaur, J; Knaus, EE; Praveen Rao, PN1
Alam, MM; Alam, MS; Kalle, AM; Mulakayala, C; Mulakayala, N; Pallu, R; Shafi, S; Vanaja, G1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Bhardwaj, A; Huang, Z; Kaur, J; Knaus, EE; Sharma, SK; Wuest, F1
Bairwa, K; Grover, J; Jachak, SM; Roy, SK; Singh, IN; Srivastava, A1
Abou-Seri, SM; Ali, MM; Hassan, GS; Kamel, G1
Choi, HE; Choi, MJ; Jin, JH; Kang, SM; Kim, KJ; Kim, M; Lee, JY; Lee, KT; Shin, JS1
Bairwa, K; Grover, J; Jachak, SM; Kumar, V; Singh, V; Sobhia, ME1
Dalby, KN; Kaoud, TS; Radwan, MF1
Govardhan Reddy, K; Kishore, B; Nagaraju, D; Rajanarendar, E; Rama Krishna, S; Reddy, YN1
Abdellatif, KR; Azoz, AA; Elshemy, HA1
Abdelall, EKA; Abdellatif, KRA; Fadaly, WAA; Kamel, GM1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Ameen, BAH; Dissanayake, AA; Nair, MG1
Kaur, A; Pathak, DP; Sharma, V; Wakode, S1
Boixareu, N; Campanera, JM; Navarro, L; Pors, K; Pouplana, R; Pujol, MD; Rosell, G; Sánchez, S1
Asif, M; Husain, A; Iqbal, MA; Iram, F; Khan, SA1
Chung, HY; Hong, J; Ju, Z; Jung, JH; Kim, S; La Kim, E; Moon, HR; Su, M1
Neha, K; Wakode, S1
Bai, R; Jiang, X; Wu, K; Zhang, P; Zhang, Y1
Catella-Lawson, F; FitzGerald, GA; Kapoor, S; Lawson, JA; Mardini, IA; McAdam, BF1
Gierse, JK; Isakson, PC; Koboldt, CM; Seibert, K; Walker, MC1
Wallace, JL1
Dionne, R1
Blondon, H1
Abou-Issa, H; Alshafie, GA; Harris, RE; Seibert, K1
Burke, A; FitzGerald, GA; Habib, A; Kapoor, S; Lawson, JA; Mardini, IA; McAdam, BF1
Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW1
Oberyszyn, TM; Parrett, ML; Ross, MS; Wilgus, TA1
Tive, L1
Browning, RA; Burgess, FW1
Ouellet, M; Percival, MD; Riendeau, D1
Simon, LS1
Zuurmond, WW1
Faich, G; Geis, GS; Lefkowith, JB; Maurath, C; Ridge, NJ; Verburg, KM; Whelton, A; White, WB1
Connor, KE; Coppola, D; DiCarlo, G; Gordon, MN; Jantzen, PT; Morgan, D; Rojiani, AM; Wallace, JL; Wenk, GL1
Chandra, A; Nair, MG; Schutzki, R; Seeram, NP1
Dieppe, PA; Jüni, P; Rutjes, AW1
Clifford, LJ; Dewitt, DL; Nair, MG; Rana, J1
McCormack, JP; Rangno, R1
Geis, GS1
Brahim, JS; Dionne, RA; Khan, AA; Rowan, JS1
Ashraf, E; Cooper, SA; Doyle, G; Jayawardena, S1
Ekman, EF; Fiechtner, JJ; Fort, JG; Levy, S1
Pfeifer, M1
Arbogast, PG; Daugherty, JR; Griffin, MR; Hall, K; Ray, WA; Stein, CM1
Fricke, JR; Kotey, P; Kress, B; Malmstrom, K; Morrison, B1
Goldberg, J; Kenwood, A; Lavery, R; Salo, DF; Shapiro, T; Varma, V1
Flavin, S; Haig, A; MacDonald, B; Palmer, R; Weiss, R; Zusman, RM1
Avşar, E; Ekenel, M; Haklar, G; Imeryüz, N; Kocakaya, O; Tözün, N; Yüksel, M1
Hawel, R; Kähler, ST; Klein, G; Mayrhofer, F; Singer, F1
Atik, U; Burak Cimen, MY; Cimen, OB; Erdoğan, C; Eskandari, G; Sahin, G1
Harley, C; Wagner, S1
Burke, TA; Goldstein, JL; Henderson, SC; Palmer, R; von Allmen, H; Zhao, SZ1
Marziniak, M; Schäfers, M; Sommer, C; Sorkin, LS; Yaksh, TL1
Burke, TA; Michaud, K; Wolfe, F; Zhao, SZ1
Cryer, B; Kimmey, MB; Riff, DS; Rothstein, RI; Scheiman, JM; Wolfe, MM1
Gotoh, T; Hoshino, T; Hwang, HJ; Mima, S; Mizushima, T; Mori, M; Takenaka, H; Tomisato, W; Tsuchiya, T; Tsutsumi, S1
Behm, A; Cox, ER; Fairman, KA; Frisse, M1
Cousin, M; Fiedorowicz-Fabrycy, IF; Gitton, X; Hawkey, CC; Hoexter, G; Nasonov, EL; Pikhlak, EG; Svoboda, P1
Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A1
Dahlborg, R; Day, CA; Jacob, RF; Mason, RP; Walter, MF; Weng, Y1
Berlin, JA; Chittams, J; Jaskowiak, J; Kimmel, SE; Kishel, L; Reilly, M; Strom, BL1
Bresee, SJ; Carroll, RC; Chavez, JJ; Cohen, E; Craft, RM; Snider, CC1
Meechan, J1
Holt, CI; Hutchins, MO; Pileggi, R1
Cho Han, D; Heum Park, J; Hyung Hong, S; Kim, J; Kwon, BM; Lee, SK; Min Kim, J; Miyazawa, K; Seog Yoon, K; Son, KH1
Couzin, J1
Abildstrom, SZ; Buch, P; Friberg, J; Gislason, GH; Jacobsen, S; Køber, L; Madsen, M; Rasmussen, JN; Rasmussen, S; Schramm, TK; Torp-Pedersen, C1
Barner, JC; Busti, AJ; Lawson, KA; Motsko, SP; Rascati, KL; Wilson, JP; Worchel, J1
De Clerck, L; De Keyser, F; Geusens, P; Hauzeur, JP; Luyten, FP; Malaise, M; Mathy, L; Raeman, F; Van den Bosch, F; Vander Mijnsbrugge, D; Westhovens, R1
Castellsague, J; Maguire, A; Perez-Gutthann, S; Varas-Lorenzo, C1
Lefkowith, JL; Verburg, KM; West, CR; Whelton, A1
Capone, ML; D'Amelio, E; De Caterina, R; Grana, M; Patrignani, P; Patrono, C; Price, TS; Renda, G; Sacchetta, D; Santarelli, F; Sciulli, MG; Tacconelli, S; Zimarino, M; Zurro, M1
Bertini, S; Bonardi, S; Coruzzi, G; Giovannini, E; Grandi, D; Menozzi, A; Pozzoli, C; Solenghi, E; Vasina, V1
Brookhart, MA; Rassen, J; Schneeweiss, S; Solomon, DH; Wang, PS1
Kong, SX; LeLorier, J; Rahme, E; Toubouti, Y; Watson, DJ1
Becker, TL; Gambero, A; Maróstica, M; Pedrazzoli, J1
Hoffmeyer, P; Keller, A; Perneger, T; Riand, N; Saudan, M; Saudan, P1
Aisenberg, J; Berger, MF; Bhadra, P; Eisen, GM; Goldstein, JL; Gralnek, IM; Lewis, B1
Alshafie, GA; Beebe-Donk, J; Harris, RE1
Andriulli, A; Colaizzo, D; Dallapiccola, B; Di Mario, F; Franceschi, M; Grandone, E; Leandro, G; Niro, V; Pilotto, A; Scarcelli, C; Seripa, D1
Afshartous, D; Alonso, AB; Preston, RA1
Dabhi, JK; Mehta, A; Solanki, JK1
Han, JA; Kim, SR; Lee, ME; Park, JH; Park, JS; Park, SC1
Aguiar, FA; de Souza, GE; do Vale, ML; Kanashiro, A; Machado, RR; Malvar, Ddo C; Pessini, AC; Soares, DM1
Becker, MC; Borer, JS; Graham, DY; Husni, ME; Krum, H; Libby, P; Lincoff, AM; Lüscher, TF; Mascette, AM; Nissen, SE; Ruschitzka, F; Solomon, DH; Wang, TH; Wisniewski, L; Wolski, K; Yeomans, ND1
Choi, KH; Chung, MW; Kim, KB; Kim, SH; Lee, HJ; Oh, HY; Oh, JS; Um, SY1
Carreras, I; Choi, JK; Cormier, K; Dedeoglu, A; Jenkins, BG; Kaymakcalan, S; Kowall, NW1
Dolezal, T; Krsiak, M; Sliva, J; Sykora, D; Vosmanska, M1
Arbogast, PG; Castellsague, J; Chung, CP; Daugherty, JR; García-Rodríguez, LA; Murray, KT; Ray, WA; Stein, CM; Varas-Lorenzo, C1
De Caterina, R; Renda, G; Romano, M; Zurro, M1
Aronoff, DM; Carlos, D; Faccioli, LH; Lourenço, EV; Machado, ER; Ramos, SG; Silva, EV; Sorgi, CA; Souza, GE; Ueta, MT1
Guo, QL; Huang, CS; Wang, Y; Yan, JQ; Zhang, X; Zou, WY1
Fermelia, DE; Kariger, R; Naruse, R; Sloninsky, A; Tang, J; Time, M; Tsushima, GK; Webb, T; Wender, RH; White, PF; Yumul, R; Zaentz, A; Zhao, M1
Janovsky, M; Krsiak, M1
Bavry, AA; Cooper-Dehoff, RM; Gong, Y; Handberg, EM; Khaliq, A; Pepine, CJ1
An, H; Jiang, DM; Luo, XJ; Ou, YS; Quan, ZX; Tan, C; Tang, K1
Borges, VF; Conklin, MW; Eliceiri, KW; Keely, PJ; Lyons, TR; Marusyk, A; O'Brien, J; Schedin, P; Tan, AC1
Dhana, N; Jongjarearnprasert, K; Kasemsarn, P; Kulthanan, K; Tuchinda, P1
Gaur, V; Kumar, A1
Niebling, W1
Al-Sukhun, J; Al-Sukhun, R; Al-Sukhun, S; Ashammakhi, N; Penttilä, H1
Cantwell, MM; Hughes, CM; Murray, LJ; Parsons, C; Reid, J1
An, H; Jiang, D; Luo, X; Ou, Y; Quan, Z; Tan, C; Tang, K1
Cerna, D; Coleman, CN; Falduto, MT; J-Aryankalayil, M; Magnuson, SR; Makinde, AY; Palayoor, ST1
Harirforoosh, S; Pettit, WL; Wyatt, JE1
Aljadhey, H; Blalock, SJ; Brater, DC; Hansen, RA; Murray, MD; Tu, W1
Hébert, RL; Karsh, J; Nasrallah, R; Robertson, SJ1
Cornelius, G; Dixon, G; Fancher, RM; Ford, K; Foster, KA; Gudmundsson, OS; Hageman, MJ; Proszynski, M; Sun, H1
Micov, AM; Stepanović-Petrović, RM; Tomić, MA1
Charoenvilaisiri, S; Poomkokruk, A; Sakonlaya, D; Tapanadechopone, P1
Corigliano, A; De Sarro, G; Falcone, D; Galasso, O; Gallelli, L; Gasparini, G; Greco, M; Gulletta, E; Romualdi, P; Savino, R; Southworth, S; Terracciano, R; Ventura, V1
Aneja, A; Farkouh, ME; Gandhi, S; Greenberg, J; Iyengar, RL; Mosovich, S; Razzouk, L; Thorpe, K1
Sifferlin, A1
Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA1
Beach, KJ; Brookhart, MA; Layton, JB; Le, HV; Poole, C; Schoenbach, VJ; Stürmer, T1
Bhardwaj, A; Kaur, J; Knaus, EE; Wuest, F1
Beshay, JE; Levy, M; Madden, CJ; Rickert, KL; Sarode, R; Scott, WW1
Fukazawa, H; Inoue, M; Kaneko, Y; Miyazaki, Y; Niki, M; Ohno, H; Tanabe, K; Umeyama, T; Urai, M1
Borba-Murad, GR; de Andrade, FG; de Fatima Silva, F; de Morais, H; de Souza, CO; de Souza, HM; Kurauti, MA1
Caimmi, D; Caimmi, SM; Demoly, P; Manca, E; Marseglia, GL1
Bannuru, RR; Kent, DM; McAlindon, TE; Schmid, CH; Vaysbrot, EE; Wong, JB1
Bannon, AW; Joshi, SK; Zhu, CZ1
Curi, R; de Morais, H; de Souza, CO; de Souza, HM; Hirabara, SM; Kurauti, MA; Rosa Neto, JC; Silva, Fde F1
Jiang, CY; Li, FL; Li, X; Li, Y; Lu, Y; Zhuo, HW1
Collins, JE; Hunter, DJ; Jordan, JM; Katz, JN; Losina, E; Paltiel, AD; Smith, SR; Solomon, DH; Suter, LG; Yelin, E1
Abdelgawad, MA; Abdellatif, KR; Alsayed, SS; Elshemy, HA1
Matteson, EL; Thongprayoon, C; Ungprasert, P1
Doods, H; Gould, SA; Lamla, T; Pekcec, A1
DiBattista, AM; Dumanis, SB; Newman, J; Rebeck, GW1
Choi, KH; Chung, MW; Lee, HJ; Park, JH; Um, SY1
Bao, W; Beckerman, B; Berger, MF; Borer, JS; Gaffney, M; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Ruschitzka, F; Solomon, DH; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND1
González-Gay, MA; González-Juanatey, C1
Nurmohamed, MT1
Armada, B; Gordo, AC; Walker, C; Zhou, D1
Grosser, T1
Nissen, SE1
Raschle, J1
McGettigan, P; Olsen, AS1
Nitschmann, S; Schrör, K1
Gannon, R; O'Sullivan, DM; Reagan, KML; Steinberg, AC1
Bauk, L; Drmic, D; Klicek, R; Kokot, A; Luetic, K; Seiwerth, S; Sikiric, P; Stupnisek, M; Vcev, A; Vitaic, S1
Ganju, J; Rom, D1
Baek, JS; Lee, YH; Loo, SCJ; Tan, NS; Yeo, EW1
Borer, JS; Brennan, DM; Husni, ME; Libby, PA; Lincoff, AM; Lϋscher, TF; Menon, V; Nissen, SE; Solomon, DH; Wisniewski, LM; Yeomans, ND1
Cañizares, FJ; Cobos, EJ; Entrena, JM; Fernández-Segura, E; Montilla-García, Á; Perazzoli, G; Portillo-Salido, E; Tejada, MÁ1
Anderson, B; Cooper, TE; Eccleston, C; Fisher, E; Wilkinson, NM1
Wang, J1
Paul, S; Sun, CC2
Breivik, H1
Gislason, G; Sondergaard, KB1
Beckerman, B; Borer, JS; Davey, DA; Fayyad, R; Flammer, AJ; Graham, DY; Husni, ME; Iorga, D; Krum, H; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Ruschitzka, F; Solomon, DH; Wisniewski, LM; Yeomans, ND1
Weintraub, WS1
Radhakrishnan, J; Radhakrishnan, R; Yellepeddi, VK1
Bao, W; Berger, MF; Borer, JS; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Solomon, DH; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND1
Chang, CH; Dong, YH; Hwang, JS; Toh, S; Wu, LC1
Bao, W; Borer, J; Graham, DY; Husni, EM; Libby, P; Lincoff, MA; Lüscher, T; Nissen, SE; Walker, C; Wang, Q; Wisniewski, LM; Wolski, K; Yeomans, ND1
Chang, CC; Chen, YR; Chi, NF; Chiou, HY; Hsieh, FI; Wu, HC1
Steurer, J1
Bao, W; Borer, JS; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Nissen, SE; Solomon, DH; Stevens, T; Vargo, J; Walker, C; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND1
Antman, EM1
Laine, L1
Graham, DY; Yeomans, ND1
Baratta, JL; Dayan, AC; Pitchon, DN; Schwenk, ES; Viscusi, ER1
Buschiazzo, HO; Cañás, M; Dorati, CM; Mordujovich-Buschiazzo, P; Prozzi, GR; Urtasun, MA1
Akinbade, AO; Ndukwe, KC; Owotade, FJ1
Husni, ME; Nissen, S; Paynter, N; Shao, M; Solomon, DH; Wolski, K1
Cicciù, M; Isola, G; Matarese, G; Matarese, M; Ramaglia, L1
Nissen, SE; Reed, GW1
Açil, Y; Gülses, A; Wiltfang, J1
Isola, G; Matarese, G1
Agger, EM; Andersen, P; Clemmensen, HS; Dyrhol-Riise, AM; Jenum, S; Mortensen, R; Mustafa, T; Therkelsen, ML; Tonby, K; Woodworth, JS1
Hajhashemi, V; Mesripour, A; Shahnooshi, S1
O'Sullivan, DM; Ramaseshan, AS; Steinberg, AC; Tunitsky-Bitton, E1
Britch, SC; Craft, RM; Hewitt, KA1
Alonso-Castro, ÁJ; Franco-de la Torre, L; Franco-González, MA; Isiordia-Espinoza, MA1
Dai, F; Hu, H; Li, X; Lv, Z; Ren, J; Wang, J; Zhang, B1
Ghosh, S1
Bao, W; Davey, DA; Husni, E; Libby, P; Lüscher, TF; Nissen, SE; Obeid, S; Ruschitzka, F; Walker, C; Wang, Q; Wisniewski, LM; Wolski, KE; Xia, F1
Barakat, A; Diaz-delCastillo, M; Heegaard, AM; Rice, ASC; Sena, ES; Soliman, N; Vollert, J; Zhang, XY1
Hjemdahl, P; Stiller, CO1
Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC1
Adema, GJ; Ansems, M; Raaijmakers, TK; Scheffer, GJ; van den Bijgaart, RJE1

Reviews

19 review(s) available for ibuprofen and celecoxib

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
    European journal of medicinal chemistry, 2019, Jun-01, Volume: 171

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Molecular Structure

2019
Contemporary advances of cyclic molecules proposed for inflammation.
    European journal of medicinal chemistry, 2021, Oct-05, Volume: 221

    Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Humans; Inflammation; Molecular Structure; Structure-Activity Relationship

2021
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
    European journal of medicinal chemistry, 2022, Feb-05, Volume: 229

    Topics: Animals; Anti-Allergic Agents; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Antiviral Agents; Drug Development; Heterocyclic Compounds; Humans; Hypoglycemic Agents; Mice; Neuroprotective Agents; Photochemotherapy; Quinoxalines; Structure-Activity Relationship; Tubulin Modulators

2022
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
    The American journal of medicine, 1999, Dec-13, Volume: 107, Issue:6A

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles

1999
Celecoxib clinical profile.
    Rheumatology (Oxford, England), 2000, Volume: 39 Suppl 2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; In Vitro Techniques; Isoenzymes; Kidney Diseases; Membrane Proteins; Middle Aged; Naproxen; Osteoarthritis; Pain; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome

2000
COX-2 inhibitors. Are they nonsteroidal anti-inflammatory drugs with a better safety profile?
    Gastroenterology clinics of North America, 2001, Volume: 30, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Forecasting; Humans; Ibuprofen; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides

2001
Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review.
    Palliative medicine, 2013, Volume: 27, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Indomethacin; Neoplasms; Pyrazoles; Quality of Life; Sulfonamides; Treatment Outcome

2013
Pharmacogenetics of nonsteroidal anti-inflammatory drugs.
    The pharmacogenomics journal, 2012, Volume: 12, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Celecoxib; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Ibuprofen; Indomethacin; Pharmacogenetics; Pyrazoles; Sulfonamides

2012
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
    Annals of internal medicine, 2015, Jan-06, Volume: 162, Issue:1

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Humans; Hyaluronic Acid; Ibuprofen; Injections, Intra-Articular; Naproxen; Osteoarthritis, Knee; Pain; Pyrazoles; Sulfonamides; Treatment Outcome; Viscosupplements

2015
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
    Stroke, 2016, Volume: 47, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles

2016
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.
    The Cochrane database of systematic reviews, 2017, 08-02, Volume: 8

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Celecoxib; Child; Child, Preschool; Chronic Disease; Chronic Pain; Fenoprofen; Humans; Ibuprofen; Lactones; Meloxicam; Methoxsalen; Naproxen; Randomized Controlled Trials as Topic; Sulfones; Thiazines; Thiazoles

2017
Updates on Multimodal Analgesia for Orthopedic Surgery.
    Anesthesiology clinics, 2018, Volume: 36, Issue:3

    Topics: Acetaminophen; Amines; Analgesia; Celecoxib; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Ibuprofen; Ketamine; Ketorolac; Orthopedic Procedures; Pain, Postoperative

2018
[Cardiovascular risk of non-steroidal anti-inflammatory drugs].
    Medicina, 2018, Volume: 78, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Celecoxib; Drug Interactions; Humans; Ibuprofen; Naproxen; Risk Factors

2018
Analgesic effectiveness and safety of celecoxib versus non-opioid active controls after third molar surgery: A meta-analytical evaluation.
    Journal of stomatology, oral and maxillofacial surgery, 2022, Volume: 123, Issue:3

    Topics: Analgesics; Celecoxib; Humans; Ibuprofen; Molar, Third; Nausea; Pain, Postoperative; Vomiting

2022
Metabolomic Studies for Metabolic Alterations Induced by Non-Steroidal Anti-Inflammatory Drugs: Mini Review.
    Biomolecules, 2021, 10-04, Volume: 11, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Humans; Ibuprofen; Inflammation; Metabolome; Metabolomics

2021
Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain.
    Pain, 2022, 11-01, Volume: 163, Issue:11

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Disease Models, Animal; Gabapentin; Ibuprofen; Male; Naproxen; Pain; Rats; Rodentia

2022
Lessons from 20 years with COX-2 inhibitors: Importance of dose-response considerations and fair play in comparative trials.
    Journal of internal medicine, 2022, Volume: 292, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Fibrinolytic Agents; Humans; Ibuprofen; Lactones; Naproxen; Prostaglandins; Prostaglandins I; Sulfones; Thromboxanes

2022
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain

2022

Trials

43 trial(s) available for ibuprofen and celecoxib

ArticleYear
[Specific cyclo-oxygenase inhibitors. 2. Gastric toxicity?].
    Presse medicale (Paris, France : 1983), 2000, Mar-11, Volume: 29, Issue:9

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhibitors; Duodenoscopy; Esophagoscopy; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Lactones; Osteoarthritis; Peptic Ulcer; Placebos; Pyrazoles; Sulfonamides; Sulfones; Time Factors

2000
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation.
    The Journal of clinical investigation, 2000, Volume: 105, Issue:10

    Topics: Adult; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Eicosanoids; Female; Humans; Ibuprofen; In Vitro Techniques; Inflammation; Isoenzymes; Lipid Peroxidation; Lipopolysaccharides; Male; Membrane Proteins; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Sulfonamides

2000
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.
    JAMA, 2000, Sep-13, Volume: 284, Issue:10

    Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Isoenzymes; Male; Membrane Proteins; Middle Aged; Osteoarthritis; Peptic Ulcer; Proportional Hazards Models; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides

2000
Comparison of thromboembolic events in patients treated with celecoxib, a cyclooxygenase-2 specific inhibitor, versus ibuprofen or diclofenac.
    The American journal of cardiology, 2002, Feb-15, Volume: 89, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Celecoxib; Coronary Thrombosis; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Ibuprofen; Male; Pyrazoles; Sulfonamides

2002
In vivo selectivity of a selective cyclooxygenase 2 inhibitor in the oral surgery model.
    Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:1

    Topics: Adult; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Humans; Ibuprofen; Isoenzymes; Male; Membrane Proteins; Microdialysis; Molar, Third; Oral Surgical Procedures; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Substrate Specificity; Sulfonamides; Thromboxane B2; Tooth Extraction

2002
Efficacy and tolerability of nonprescription ibuprofen versus celecoxib for dental pain.
    Journal of clinical pharmacology, 2002, Volume: 42, Issue:8

    Topics: Adolescent; Adult; Celecoxib; Dosage Forms; Double-Blind Method; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Male; Nonprescription Drugs; Pain, Postoperative; Pyrazoles; Sulfonamides; Time Factors; Tooth Extraction

2002
Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain.
    American journal of orthopedics (Belle Mead, N.J.), 2002, Volume: 31, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Aged; Pain Measurement; Pyrazoles; Sprains and Strains; Sulfonamides; Treatment Outcome

2002
A comparison of rofecoxib versus celecoxib in treating pain after dental surgery: a single-center, randomized, double-blind, placebo- and active-comparator-controlled, parallel-group, single-dose study using the dental impaction pain model.
    Clinical therapeutics, 2002, Volume: 24, Issue:10

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction

2002
A randomized, clinical trial comparing oral celecoxib 200 mg, celecoxib 400 mg, and ibuprofen 600 mg for acute pain.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2003, Volume: 10, Issue:1

    Topics: Acute Disease; Adult; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Ibuprofen; Male; Pain; Pain Measurement; Pyrazoles; Sulfonamides; Time Factors

2003
Effects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitors.
    American journal of hypertension, 2003, Volume: 16, Issue:2

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Butanones; Celecoxib; Female; Humans; Hypertension; Ibuprofen; Male; Middle Aged; Nabumetone; Pyrazoles; Sulfonamides

2003
Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen.
    European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Double-Blind Method; Gastric Mucosa; Humans; Ibuprofen; Isoenzymes; Male; Membrane Proteins; Permeability; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Stomach; Sucrose; Sulfonamides

2003
Comparison of the efficacy and tolerability of dexibuprofen and celecoxib in the treatment of osteoarthritis of the hip.
    International journal of clinical pharmacology and therapeutics, 2003, Volume: 41, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Isoenzymes; Male; Membrane Proteins; Middle Aged; Osteoarthritis, Hip; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Severity of Illness Index; Stereoisomerism; Sulfonamides; Treatment Outcome

2003
In vivo effects of meloxicam, celecoxib, and ibuprofen on free radical metabolism in human erythrocytes.
    Drug and chemical toxicology, 2003, Volume: 26, Issue:3

    Topics: Catalase; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Erythrocytes; Free Radical Scavengers; Glutathione Peroxidase; Humans; Ibuprofen; Isoenzymes; Malondialdehyde; Meloxicam; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Superoxide Dismutase; Thiazines; Thiazoles

2003
A randomized, controlled comparison of ibuprofen at the maximal over-the-counter dose compared with prescription-dose celecoxib on upper gastrointestinal mucosal injury.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2004, Volume: 2, Issue:4

    Topics: Adolescent; Adult; Aged; Celecoxib; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Ibuprofen; Intestinal Mucosa; Male; Maximum Tolerated Dose; Middle Aged; Naproxen; Nonprescription Drugs; Probability; Pyrazoles; Reference Values; Risk Assessment; Sensitivity and Specificity; Sulfonamides

2004
Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis.
    The Journal of rheumatology, 2004, Volume: 31, Issue:9

    Topics: Aged; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Incidence; Male; Middle Aged; Organic Chemicals; Osteoarthritis; Peptic Ulcer; Pyrazoles; Risk Factors; Sulfonamides

2004
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
    The British journal of oral & maxillofacial surgery, 2006, Volume: 44, Issue:2

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction

2006
A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip.
    Annals of the rheumatic diseases, 2007, Volume: 66, Issue:1

    Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemotherapy, Adjuvant; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Pilot Projects; Prospective Studies; Pyrazoles; Statistics, Nonparametric; Sulfonamides; Treatment Outcome

2007
Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen.
    Kidney international, 2006, Volume: 70, Issue:8

    Topics: Acid-Base Equilibrium; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Pressure; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Edema; Female; Glomerular Filtration Rate; Heart; Humans; Hyponatremia; Ibuprofen; Kidney; Male; Middle Aged; Osteoarthritis; Pyrazoles; Sulfonamides

2006
Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

    Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Celecoxib; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ibuprofen; Male; Middle Aged; Myocardial Ischemia; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrazoles; Sulfonamides; Thromboxane B2; Treatment Outcome

2006
Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial.
    The Journal of bone and joint surgery. British volume, 2007, Volume: 89, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Ibuprofen; Male; Middle Aged; Ossification, Heterotopic; Postoperative Care; Prospective Studies; Pyrazoles; Severity of Illness Index; Single-Blind Method; Sulfonamides

2007
Small bowel mucosal injury is reduced in healthy subjects treated with celecoxib compared with ibuprofen plus omeprazole, as assessed by video capsule endoscopy.
    Alimentary pharmacology & therapeutics, 2007, May-15, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Celecoxib; Drug Therapy, Combination; Female; Humans; Ibuprofen; Intestinal Diseases; Intestinal Mucosa; Male; Middle Aged; Omeprazole; Pyrazoles; Sulfonamides

2007
Effects of selective vs. nonselective cyclooxygenase inhibition on dynamic renal potassium excretion: a randomized trial.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Female; Humans; Ibuprofen; Kidney; Male; Middle Aged; Models, Statistical; Potassium; Pyrazoles; Research Design; Sulfonamides; Time Factors

2008
Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis.
    American heart journal, 2009, Volume: 157, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Humans; Ibuprofen; Middle Aged; Naproxen; Prospective Studies; Pyrazoles; Sulfonamides; Treatment Outcome

2009
Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors.
    British journal of clinical pharmacology, 2010, Volume: 69, Issue:3

    Topics: Aged; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Humans; Ibuprofen; Lipoxins; Middle Aged; Myocardial Ischemia; Osteoarthritis; Placebo Effect; Pyrazoles; Sulfonamides

2010
The effects of oral ibuprofen and celecoxib in preventing pain, improving recovery outcomes and patient satisfaction after ambulatory surgery.
    Anesthesia and analgesia, 2011, Volume: 112, Issue:2

    Topics: Activities of Daily Living; Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chi-Square Distribution; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Italy; Los Angeles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Placebo Effect; Prospective Studies; Pyrazoles; Recovery of Function; Sulfonamides; Surveys and Questionnaires; Time Factors; Treatment Outcome

2011
Preemptive analgesic effect of low doses of celecoxib is superior to low doses of traditional nonsteroidal anti-inflammatory drugs.
    The Journal of craniofacial surgery, 2012, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Least-Squares Analysis; Male; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Placebos; Proportional Hazards Models; Prospective Studies; Pyrazoles; Sulfonamides; Tooth Extraction; Treatment Outcome

2012
The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.
    Osteoarthritis and cartilage, 2013, Volume: 21, Issue:9

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Cytokines; Diclofenac; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis, Knee; Pyrazoles; Quality of Life; Signal Transduction; Sulfonamides; Synovial Fluid; Treatment Outcome

2013
NSAIDs are associated with lower depression scores in patients with osteoarthritis.
    The American journal of medicine, 2013, Volume: 126, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Depression; Double-Blind Method; Drug Administration Schedule; Female; Humans; Ibuprofen; Logistic Models; Male; Middle Aged; Multivariate Analysis; Naproxen; Osteoarthritis; Psychological Tests; Pyrazoles; Sulfonamides; Surveys and Questionnaires; Treatment Outcome

2013
Assessment of common nonsteroidal anti-inflammatory medications by whole blood aggregometry: a clinical evaluation for the perioperative setting.
    World neurosurgery, 2014, Volume: 82, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Celecoxib; Cyclooxygenase Inhibitors; Female; Healthy Volunteers; Humans; Ibuprofen; Male; Meloxicam; Middle Aged; Naproxen; Perioperative Care; Platelet Aggregation; Pyrazoles; Sulfonamides; Thiazines; Thiazoles; Young Adult

2014
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Intention to Treat Analysis; Kidney Diseases; Male; Middle Aged; Naproxen; Risk

2016
Efficacy of celecoxib versus ibuprofen for the treatment of patients with osteoarthritis of the knee: A randomized double-blind, non-inferiority trial.
    The Journal of international medical research, 2017, Volume: 45, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Humans; Ibuprofen; Knee Joint; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Placebos; Treatment Outcome

2017
    Praxis, 2017, Volume: 106, Issue:8

    Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ibuprofen; Male; Naproxen; Osteoarthritis; Proton Pump Inhibitors; Survival Analysis; United States; United States Food and Drug Administration

2017
Decreasing postoperative narcotics in reconstructive pelvic surgery: a randomized controlled trial.
    American journal of obstetrics and gynecology, 2017, Volume: 217, Issue:3

    Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Antiemetics; Celecoxib; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Drug Utilization; Female; Gabapentin; gamma-Aminobutyric Acid; Gynecologic Surgical Procedures; Humans; Ibuprofen; Intraoperative Care; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Care; Premedication

2017
The Risk of Major NSAID Toxicity with Celecoxib, Ibuprofen, or Naproxen: A Secondary Analysis of the PRECISION Trial.
    The American journal of medicine, 2017, Volume: 130, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Osteoarthritis

2017
Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial.
    The Journal of international medical research, 2018, Volume: 46, Issue:1

    Topics: Adalimumab; Aged; Antirheumatic Agents; Celecoxib; Diclofenac; Female; Humans; Hyaluronic Acid; Ibuprofen; Injections, Intra-Articular; Male; Meloxicam; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Patient Safety; Pilot Projects; Severity of Illness Index; Thiazines; Thiazoles; Treatment Outcome

2018
Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement)
    European heart journal, 2017, Nov-21, Volume: 38, Issue:44

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Pressure; Celecoxib; Coronary Artery Disease; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Hypertension; Ibuprofen; Male; Naproxen; Osteoarthritis; Prospective Studies

2017
Differences in Safety of Nonsteroidal Antiinflammatory Drugs in Patients With Osteoarthritis and Patients With Rheumatoid Arthritis: A Randomized Clinical Trial.
    Arthritis & rheumatology (Hoboken, N.J.), 2018, Volume: 70, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; Double-Blind Method; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Kidney Diseases; Male; Middle Aged; Naproxen; Osteoarthritis; Risk Factors; Treatment Outcome

2018
    Praxis, 2018, Volume: 107, Issue:8

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Humans; Ibuprofen; Oxycodone; Pain, Postoperative; Recurrence; Risk Factors; Rotator Cuff Injuries; Tramadol

2018
Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Celecoxib; Double-Blind Method; Drug Therapy, Combination; Esomeprazole; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Osteoarthritis; Treatment Outcome

2018
Comparative Analgesic Effects of Ibuprofen, Celecoxib and Tramadol after third Molar Surgery: A Randomized Double Blind Controlled Trial.
    The journal of contemporary dental practice, 2018, Nov-01, Volume: 19, Issue:11

    Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Double-Blind Method; Female; Humans; Ibuprofen; Male; Mandible; Middle Aged; Molar, Third; Pain, Postoperative; Time Factors; Tooth Extraction; Tooth, Impacted; Tramadol; Treatment Outcome; Young Adult

2018
Derivation and Validation of a Major Toxicity Risk Score Among Nonsteroidal Antiinflammatory Drug Users Based on Data From a Randomized Controlled Trial.
    Arthritis & rheumatology (Hoboken, N.J.), 2019, Volume: 71, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Osteoarthritis; Reproducibility of Results; Risk Assessment; Risk Factors

2019
Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial.
    International journal of oral and maxillofacial surgery, 2019, Volume: 48, Issue:10

    Topics: Celecoxib; Double-Blind Method; Humans; Ibuprofen; Molar, Third; Pain, Postoperative; Tooth Extraction; Tooth, Impacted

2019
Cardiorenal risk of celecoxib compared with naproxen or ibuprofen in arthritis patients: insights from the PRECISION trial.
    European heart journal. Cardiovascular pharmacotherapy, 2022, Sep-03, Volume: 8, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; Humans; Ibuprofen; Naproxen; Prospective Studies

2022

Other Studies

144 other study(ies) available for ibuprofen and celecoxib

ArticleYear
Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity.
    Journal of medicinal chemistry, 2001, Aug-30, Volume: 44, Issue:18

    Topics: Abdominal Muscles; Androstenols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Isoenzymes; Membrane Proteins; Models, Molecular; Muscle Contraction; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship

2001
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Aug-05, Volume: 100, Issue:16

    Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors

2003
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 2003, Nov-06, Volume: 46, Issue:23

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Edema; Isoenzymes; Membrane Proteins; Models, Molecular; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrans; Pyrones; Rats; Structure-Activity Relationship; Sulfones

2003
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 2004, Jul-29, Volume: 47, Issue:16

    Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Isoenzymes; Membrane Proteins; Models, Molecular; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrans; Pyrones; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfones

2004
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.
    Bioorganic & medicinal chemistry letters, 2005, Apr-01, Volume: 15, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Binding Sites; Curcumin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship

2005
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhibitors; Drug Design; Edema; Female; Foot; Formaldehyde; Inflammation; Male; Rats; Rats, Sprague-Dawley; Thiazoles

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Amino Acid Sequence; Ascomycota; Benzopyrans; Enzyme Inhibitors; Fungal Proteins; Melanins; Models, Molecular; Molecular Sequence Data; Oxidoreductases Acting on CH-CH Group Donors; Recombinant Proteins; Structural Homology, Protein; Substrate Specificity

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.
    Bioorganic & medicinal chemistry, 2008, Nov-15, Volume: 16, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Drug Design; Esters; Hydrazines; Inhibitory Concentration 50; Nitric Oxide; Nitric Oxide Donors; Prodrugs; Pyrazoles; Pyrrolidines; Rats; Sulfonamides

2008
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

    Topics: Acetylene; Alkynes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Ibuprofen; Inflammation; Inhibitory Concentration 50; Isoenzymes; Lipoxygenase Inhibitors; Models, Chemical; Pyridones; Rats

2009
Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Pyrazoles; Spectrophotometry, Infrared; Sulfonamides

2009
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.
    Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14

    Topics: Animals; Anti-Inflammatory Agents; Azo Compounds; Cyclooxygenase Inhibitors; Edema; Foot; Humans; Nitric Oxide; Nitric Oxide Donors; Prodrugs; Prostaglandin-Endoperoxide Synthases; Rats; Sheep

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.
    Bioorganic & medicinal chemistry letters, 2010, Feb-15, Volume: 20, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Celecoxib; Crystallography, X-Ray; Cyclooxygenase 2 Inhibitors; Humans; Hydrogen-Ion Concentration; Ibuprofen; Inhibitory Concentration 50; Molecular Structure; Nitric Oxide; Nitric Oxide Donors; Piperidines; Prodrugs; Pyrazoles; Rats; Sheep; Structure-Activity Relationship; Sulfonamides

2010
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.
    Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15

    Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Humans; Hydrazines; Nitric Oxide; Nitric Oxide Donors; Nitrosamines; Prodrugs; Pyrazoles; Rats; Sulfonamides

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclooxygenase Inhibitors; Edema; Female; Male; Mice; Pyrroles

2011
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: 4-Butyrolactone; Animals; Cyclooxygenase 2 Inhibitors; Esters; Inhibitory Concentration 50; Mesenteric Arteries; Molecular Structure; Nitric Oxide Donors; Prodrugs; Rats; Sulfones; Triazenes

2011
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.
    Bioorganic & medicinal chemistry letters, 2011, Oct-15, Volume: 21, Issue:20

    Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Models, Molecular; Pyrazoles; Rats; Sulfonamides

2011
Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzothiazoles; Click Chemistry; Cyclooxygenase Inhibitors; Edema; Female; Humans; Male; Models, Molecular; Nociception; Rats; Rats, Wistar; Triazoles

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.
    Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1

    Topics: Acridines; Acridones; Biomarkers, Tumor; Celecoxib; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Fluorescent Dyes; Humans; Ibuprofen; Microscopy, Confocal; Protein Binding; Pyrazoles; Rhodamines; Structure-Activity Relationship; Sulfonamides

2013
Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.
    Journal of natural products, 2013, Aug-23, Volume: 76, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Female; Flavonoids; India; Molecular Structure; Nyctaginaceae; Plant Roots; Rats; Rats, Sprague-Dawley; Rotenone

2013
Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: design, synthesis and evaluation as potential anti-inflammatory agents.
    European journal of medicinal chemistry, 2014, Apr-09, Volume: 76

    Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Evaluation, Preclinical; Magnetic Resonance Spectroscopy; Male; Molecular Docking Simulation; Pyrazoles; Rats; Rats, Wistar; Sulfonamides

2014
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.
    Bioorganic & medicinal chemistry letters, 2014, Apr-15, Volume: 24, Issue:8

    Topics: Anti-Inflammatory Agents; Benzoquinones; Binding Sites; Catalytic Domain; Cell Survival; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Hydrogen Bonding; Inhibitory Concentration 50; Macrophages; Models, Molecular; Molecular Docking Simulation; Protein Binding; Pyrroles; Structure-Activity Relationship

2014
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.
    European journal of medicinal chemistry, 2014, Jun-10, Volume: 80

    Topics: Absorption, Physicochemical; Animals; Anthraquinones; Catalytic Domain; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Inhibitory Concentration 50; Molecular Docking Simulation; Naphthalenes; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2014
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
    ACS medicinal chemistry letters, 2014, Sep-11, Volume: 5, Issue:9

    Topics:

2014
Environmentally benign synthesis, molecular properties prediction and anti-inflammatory activity of novel isoxazolo[5,4-d]isoxazol-3-yl-aryl-methanones via vinylogous Henry nitroaldol adducts as synthons.
    Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Heterocyclic Compounds, 3-Ring; Isoxazoles; Molecular Structure; Nitro Compounds; Rats; Rats, Wistar; Structure-Activity Relationship

2015
1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents.
    Bioorganic chemistry, 2015, Volume: 63

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Pyrazoles; Structure-Activity Relationship

2015
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Pyrazoles; Ulcer

2016
Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.
    Journal of natural products, 2017, 09-22, Volume: 80, Issue:9

    Topics: Anti-Inflammatory Agents; Antioxidants; Coumarins; Cyclooxygenase Inhibitors; Lipid Peroxidation; Molecular Structure; Plant Extracts; Tetrazoles; Tetrazolium Salts; Thiazoles

2017
Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2018, 02-15, Volume: 26, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Benzoxazoles; Binding Sites; Catalytic Domain; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Half-Life; Humans; Molecular Docking Simulation; Rats; Rats, Wistar; Structure-Activity Relationship

2018
Synthesis and biological properties of aryl methyl sulfones.
    Bioorganic & medicinal chemistry, 2018, 08-07, Volume: 26, Issue:14

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edema; Humans; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfones; Thermodynamics

2018
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.
    European journal of medicinal chemistry, 2019, Oct-15, Volume: 180

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Mice; Models, Molecular; Molecular Structure; RAW 264.7 Cells; Sheep; Structure-Activity Relationship; Urochordata

2019
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Jan-05, Volume: 96, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Female; Humans; Ibuprofen; Isoenzymes; Male; Membrane Proteins; Middle Aged; Monocytes; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane B2

1999
Kinetic basis for selective inhibition of cyclo-oxygenases.
    The Biochemical journal, 1999, May-01, Volume: 339 ( Pt 3)

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Male; Membrane Proteins; Mice; Naproxen; Oxygen; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sheep; Structure-Activity Relationship; Sulfonamides; Tetramethylphenylenediamine; Thermodynamics

1999
COX-2 inhibitors: better than ibuprofen for dental pain?
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1999, Volume: 20, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Toothache

1999
Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.
    Cancer research, 2000, Apr-15, Volume: 60, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Body Weight; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Ibuprofen; Isoenzymes; Mammary Neoplasms, Animal; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Substrate Specificity; Sulfonamides

2000
Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation.
    Prostaglandins & other lipid mediators, 2000, Volume: 62, Issue:4

    Topics: Administration, Topical; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatitis; Dinoprostone; Edema; Epidermis; Female; Ibuprofen; Isoenzymes; Mice; Mice, Hairless; Neutrophils; Peroxidase; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin; Sulfonamides; Sunburn; Ultraviolet Rays

2000
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
    Medicine and health, Rhode Island, 2001, Volume: 84, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors

2001
A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Dec-04, Volume: 98, Issue:25

    Topics: Acetylation; Animals; Aspirin; Blood Platelets; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Humans; Ibuprofen; In Vitro Techniques; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sheep; Sulfonamides; Sulfones

2001
[Side effects cause enormous costs. Expensive arthritis therapy].
    MMW Fortschritte der Medizin, 2001, Nov-15, Volume: 143, Issue:46

    Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Drug Costs; Gastrointestinal Diseases; Humans; Ibuprofen; Lactones; Nabumetone; Patient Satisfaction; Pyrazoles; Sulfonamides; Sulfones

2001
Pain treatment with NSAIDs, primary focus on ibuprofen.
    Clinical rheumatology, 2001, Volume: 20 Suppl 1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Pain; Pyrazoles; Sulfonamides

2001
Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Mar-15, Volume: 22, Issue:6

    Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Celecoxib; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Flurbiprofen; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Ibuprofen; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Nitric Oxide; Presenilin-1; Pyrazoles; Sulfonamides; Treatment Outcome

2002
Characterization, quantification, and bioactivities of anthocyanins in Cornus species.
    Journal of agricultural and food chemistry, 2002, Apr-24, Volume: 50, Issue:9

    Topics: Anthocyanins; Antioxidants; Celecoxib; Chromatography, High Pressure Liquid; Cornus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fruit; Ibuprofen; Isoenzymes; Lactones; Naproxen; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones

2002
Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs?
    BMJ (Clinical research ed.), 2002, Jun-01, Volume: 324, Issue:7349

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Isoenzymes; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Research Design; Stomach Ulcer; Sulfonamides

2002
Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:3

    Topics: Aedes; Amides; Animals; Anti-Inflammatory Agents; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Echinacea; Ibuprofen; Isoenzymes; Lactones; Lethal Dose 50; Naproxen; Phytotherapy; Plant Extracts; Plant Roots; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones

2002
Digging for data from the COX-2 trials.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Jun-25, Volume: 166, Issue:13

    Topics: Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Peptic Ulcer; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome

2002
Are selective COX 2 inhibitors superior to traditional NSAIDs? Pharmacia's response to editorial.
    BMJ (Clinical research ed.), 2002, Jul-20, Volume: 325, Issue:7356

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diclofenac; Drug Therapy, Combination; Humans; Ibuprofen; Peptic Ulcer; Pyrazoles; Sulfonamides

2002
[Analgesic in osteoporosis. Why so conservative with dosage?].
    MMW Fortschritte der Medizin, 2002, Sep-05, Volume: 144, Issue:35-36

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Humans; Ibuprofen; Lactones; Middle Aged; Osteoporosis; Pyrazoles; Risk Factors; Sulfonamides; Sulfones

2002
COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease.
    Lancet (London, England), 2002, Oct-05, Volume: 360, Issue:9339

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Coronary Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Medicaid; Membrane Proteins; Middle Aged; Naproxen; Product Surveillance, Postmarketing; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Regression Analysis; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones; Tennessee

2002
[Rapid, strong and long-term effectiveness. Coxib also effective in toothache].
    MMW Fortschritte der Medizin, 2003, Jan-16, Volume: 145, Issue:1-2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones; Tooth Extraction; Toothache; Treatment Outcome

2003
Persistence with COX-2 inhibitors in managed care: an analysis of claims data.
    Managed care interface, 2003, Volume: 16, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Utilization Review; Female; Health Care Costs; Humans; Ibuprofen; Insurance Claim Review; Isoenzymes; Lactones; Male; Managed Care Programs; Membrane Proteins; Middle Aged; Naproxen; Patient Compliance; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Regression Analysis; Sulfonamides; Sulfones; United States

2003
Incidence of outpatient physician claims for upper gastrointestinal symptoms among new users of celecoxib, ibuprofen, and naproxen in an insured population in the United States.
    The American journal of gastroenterology, 2003, Volume: 98, Issue:12

    Topics: Abdominal Pain; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Dyspepsia; Female; Humans; Ibuprofen; Incidence; Insurance Claim Reporting; Male; Middle Aged; Naproxen; Nausea; Outpatients; Poisson Distribution; Proportional Hazards Models; Pyrazoles; Risk Factors; Sulfonamides; United States; Vomiting

2003
Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat.
    Experimental neurology, 2004, Volume: 185, Issue:1

    Topics: Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Ibuprofen; Isoenzymes; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Spinal Cord; Sulfonamides; Tumor Necrosis Factor-alpha

2004
Longer use of COX-2-specific inhibitors compared to nonspecific nonsteroidal antiinflammatory drugs: a longitudinal study of 3639 patients in community practice.
    The Journal of rheumatology, 2004, Volume: 31, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Community Health Services; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Fibromyalgia; Follow-Up Studies; Humans; Ibuprofen; Isoenzymes; Lactones; Longitudinal Studies; Male; Membrane Proteins; Middle Aged; Naproxen; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Surveys and Questionnaires

2004
Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis.
    Cell death and differentiation, 2004, Volume: 11, Issue:9

    Topics: Activating Transcription Factor 4; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Northern; Celecoxib; Cell Line; Cell Survival; Cells, Cultured; Diclofenac; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gastric Mucosa; Genes, Reporter; Guinea Pigs; Heat-Shock Proteins; Hydrogen Peroxide; Ibuprofen; Immunoblotting; Indomethacin; Luciferases; Macrophages; Microscopy, Fluorescence; Molecular Chaperones; Plasmids; Pyrazoles; Regulatory Factor X Transcription Factors; RNA, Messenger; Sulfonamides; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; X-Box Binding Protein 1

2004
Over-the-counter pain reliever and aspirin use within a sample of long-term cyclooxygenase 2 users.
    Archives of internal medicine, 2004, Jun-14, Volume: 164, Issue:11

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Nonprescription Drugs; Pyrazoles; Sulfonamides

2004
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:5

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flurbiprofen; Ibuprofen; Isoenzymes; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thrombosis

2004
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs.
    Atherosclerosis, 2004, Volume: 177, Issue:2

    Topics: Animals; Antioxidants; Celecoxib; Cholesterol, LDL; Chromans; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Isoprostanes; Isoxazoles; Lactones; Meloxicam; Naproxen; Oxidation-Reduction; Pyrazoles; Sulfonamides; Sulfones; Thiazines; Thiazoles

2004
Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction.
    Annals of internal medicine, 2005, Feb-01, Volume: 142, Issue:3

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bias; Case-Control Studies; Celecoxib; Confounding Factors, Epidemiologic; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Odds Ratio; Pyrazoles; Risk Factors; Sulfonamides; Sulfones

2005
A Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid.
    The Journal of laboratory and clinical medicine, 2005, Volume: 146, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Dose-Response Relationship, Drug; Humans; Ibuprofen; Platelet Activation; Platelet Aggregation; Pyrazoles; Sulfonamides; Thrombelastography

2005
A real time quantitative PCR analysis and correlation of COX-1 and COX-2 enzymes in inflamed dental pulps following administration of three different NSAIDs.
    Journal of endodontics, 2005, Volume: 31, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dental Pulp Exposure; Ibuprofen; Lactones; Male; Pulpitis; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Sulfones

2005
Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen.
    Life sciences, 2006, Apr-04, Volume: 78, Issue:19

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cell Line; Electrophoresis, Gel, Two-Dimensional; Humans; Ibuprofen; Mass Spectrometry; Protein Biosynthesis; Pyrazoles; Sulfonamides; Synovial Membrane

2006
Drug testing. Massive trial of Celebrex seeks to settle safety concerns.
    Science (New York, N.Y.), 2005, Dec-23, Volume: 310, Issue:5756

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Confounding Factors, Epidemiologic; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Heart Diseases; Humans; Ibuprofen; Membrane Proteins; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Sulfonamides

2005
Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs after acute myocardial infarction.
    Circulation, 2006, Jun-27, Volume: 113, Issue:25

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Confidence Intervals; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Denmark; Diclofenac; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Patient Readmission; Proportional Hazards Models; Pyrazoles; Recurrence; Registries; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones

2006
Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk.
    Drug safety, 2006, Volume: 29, Issue:7

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Etodolac; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Naproxen; Pyrazoles; Sulfonamides; Sulfones; Time Factors; United States; Veterans

2006
Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level.
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Computer Simulation; Coronary Disease; Cyclooxygenase Inhibitors; Diclofenac; Female; Heart Failure; Humans; Ibuprofen; Male; Middle Aged; Models, Statistical; Naproxen; Peptic Ulcer; Population Surveillance; Pyrazoles; Risk Assessment; Risk Factors; Stroke; Sulfonamides; United States

2007
Intestinal effects of nonselective and selective cyclooxygenase inhibitors in the rat.
    European journal of pharmacology, 2006, Dec-15, Volume: 552, Issue:1-3

    Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enterobacteriaceae; Ibuprofen; Indomethacin; Intestinal Mucosa; Intestine, Small; Lipid Peroxidation; Male; Mucins; Peroxidase; Pyrazoles; Rats; Rats, Wistar; Sulfonamides

2006
Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis.
    Arthritis and rheumatism, 2006, Volume: 54, Issue:11

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Lactones; Male; Multivariate Analysis; Myocardial Infarction; Naproxen; Pyrazoles; Rheumatic Diseases; Risk Assessment; Risk Factors; Sulfonamides; Sulfones

2006
Association between nonnaproxen NSAIDs, COX-2 inhibitors and hospitalization for acute myocardial infarction among the elderly: a retrospective cohort study.
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:5

    Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Prescriptions; Drug Utilization; Female; Hospitalization; Humans; Ibuprofen; Lactones; Male; Myocardial Infarction; Product Surveillance, Postmarketing; Proportional Hazards Models; Pyrazoles; Quebec; Retrospective Studies; Sex Factors; Sulfonamides; Sulfones

2007
Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:2

    Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytoprotection; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Acid; Gastric Mucosa; Ibuprofen; Irritants; Male; Meloxicam; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides; Thiazines; Thiazoles

2007
Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study.
    International journal of biological sciences, 2007, Jun-13, Volume: 3, Issue:5

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Celecoxib; Chemoprevention; Cyclooxygenase 2 Inhibitors; Female; Humans; Ibuprofen; Lactones; Logistic Models; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Ohio; Pyrazoles; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones

2007
Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms.
    Gastroenterology, 2007, Volume: 133, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Case-Control Studies; Celecoxib; Cytochrome P-450 CYP2C9; Diclofenac; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Odds Ratio; Peptic Ulcer; Peptic Ulcer Hemorrhage; Piroxicam; Polymorphism, Single Nucleotide; Pyrazoles; Risk Assessment; Risk Factors; Sulfonamides

2007
Antiatherosclerotic activity of ibuprofen, a non-selective COX inhibitor--an animal study.
    Indian journal of experimental biology, 2008, Volume: 46, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Aspirin; Atherosclerosis; Celecoxib; Disease Models, Animal; Female; Hypercholesterolemia; Hypolipidemic Agents; Ibuprofen; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides

2008
Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner.
    Mechanisms of ageing and development, 2008, Volume: 129, Issue:12

    Topics: Aspirin; Caveolin 1; Celecoxib; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fibroblasts; Flurbiprofen; Humans; Ibuprofen; Kinetics; Models, Biological; NF-kappa B; Nitrobenzenes; Pyrazoles; Reactive Oxygen Species; Skin; Skin Aging; Sulfonamides; Tumor Suppressor Protein p53

2008
Characterization and pharmacological evaluation of febrile response on zymosan-induced arthritis in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Body Temperature; Celecoxib; Dexamethasone; Dinoprostone; Dipyrone; Dose-Response Relationship, Drug; Fever; Ibuprofen; Injections, Intra-Articular; Male; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Zymosan

2009
Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats.
    Analytical chemistry, 2009, Jun-15, Volume: 81, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Ibuprofen; Indomethacin; Least-Squares Analysis; Magnetic Resonance Spectroscopy; Male; Metabolomics; Pattern Recognition, Automated; Predictive Value of Tests; Pyrazoles; Rats; Rats, Sprague-Dawley; Stomach; Sulfonamides

2009
Anti-inflammatory treatment in AD mice protects against neuronal pathology.
    Experimental neurology, 2010, Volume: 223, Issue:2

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Frontal Lobe; Hippocampus; Humans; Ibuprofen; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Presenilins; Pyrazoles; Sulfonamides

2010
Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice.
    Neuro endocrinology letters, 2009, Volume: 30, Issue:3

    Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Synergism; Expectorants; Guaifenesin; Ibuprofen; Male; Mice; Pain; Pain Measurement; Pyrazoles; Sulfonamides

2009
Cardiovascular risks of nonsteroidal antiinflammatory drugs in patients after hospitalization for serious coronary heart disease.
    Circulation. Cardiovascular quality and outcomes, 2009, Volume: 2, Issue:3

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cohort Studies; Coronary Artery Disease; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Follow-Up Studies; Hospitalization; Humans; Ibuprofen; Incidence; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Outpatients; Pyrazoles; Retrospective Studies; Risk Factors; Stroke; Sulfonamides; Sulfones; Tennessee

2009
Cyclooxygenase-derived mediators regulate the immunological control of Strongyloides venezuelensis infection.
    FEMS immunology and medical microbiology, 2010, Jun-01, Volume: 59, Issue:1

    Topics: Animals; Ascitic Fluid; Blood; Bronchoalveolar Lavage Fluid; Celecoxib; Dinoprostone; Duodenum; Enzyme Inhibitors; Eosinophils; Ibuprofen; Indomethacin; Leukocytes, Mononuclear; Lung; Male; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Strongyloides; Strongyloidiasis; Sulfonamides; Th1 Cells; Th2 Cells

2010
Cyclooxygenase inhibitors suppress the expression of P2X(3) receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats.
    Neuroscience letters, 2010, Jul-05, Volume: 478, Issue:2

    Topics: Animals; Celecoxib; Constriction, Pathologic; Cyclooxygenase Inhibitors; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Ibuprofen; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Sciatic Nerve; Sulfonamides; Touch

2010
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.
    Neuro endocrinology letters, 2011, Volume: 32, Issue:2

    Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Celecoxib; Codeine; Cyclooxygenase 2 Inhibitors; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Etoricoxib; Ibuprofen; Male; Mice; Mice, Inbred Strains; Models, Animal; Pain; Pyrazoles; Pyridines; Regression Analysis; Sulfonamides; Sulfones

2011
Harmful effects of NSAIDs among patients with hypertension and coronary artery disease.
    The American journal of medicine, 2011, Volume: 124, Issue:7

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Celecoxib; Confounding Factors, Epidemiologic; Coronary Artery Disease; Diclofenac; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypertension; Ibuprofen; Indoles; Kaplan-Meier Estimate; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Myocardial Infarction; Naproxen; Odds Ratio; Proportional Hazards Models; Pyrazoles; Randomized Controlled Trials as Topic; Stroke; Sulfonamides; Verapamil

2011
The effects of NSAIDs on types I, II, and III collagen metabolism in a rat osteoarthritis model.
    Rheumatology international, 2012, Volume: 32, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Celecoxib; Chondrocytes; Collagen Type I; Collagen Type II; Collagen Type III; Disease Models, Animal; Ibuprofen; Immunohistochemistry; Indomethacin; Osteoarthritis; Proteoglycans; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Time Factors

2012
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.
    Nature medicine, 2011, Aug-07, Volume: 17, Issue:9

    Topics: Analysis of Variance; Animals; Blotting, Western; Breast Neoplasms; Carcinoma, Ductal; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2; Disease Models, Animal; Female; Fibrillar Collagens; Humans; Ibuprofen; Immunohistochemistry; In Situ Hybridization, Fluorescence; Mammary Glands, Animal; Mice; Mice, SCID; Neoplasm Invasiveness; Postpartum Period; Pregnancy; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides

2011
Cutaneous reactions to non-steroidal anti-inflammatory drugs.
    Journal of drugs in dermatology : JDD, 2011, Volume: 10, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Ibuprofen; Male; Middle Aged; Pyrazoles; Retrospective Studies; Sulfonamides; Urticaria; Young Adult

2011
Effect of nonselective and selective COX-2 inhibitors on memory dysfunction, glutathione system, and tumor necrosis factor alpha level against cerebral ischemia reperfusion injury.
    Drug and chemical toxicology, 2012, Volume: 35, Issue:2

    Topics: Acetylcholinesterase; Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 2 Inhibitors; Glutathione; Hippocampus; Ibuprofen; Male; Maze Learning; Memory Disorders; Pyrazoles; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides; Tumor Necrosis Factor-alpha

2012
[Bringing evidence to practice: obstacles and barriers].
    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen, 2011, Volume: 105, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Comparative Effectiveness Research; Conflict of Interest; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Approval; Drug Industry; Evidence-Based Medicine; Germany; Humans; Ibuprofen; Peptic Ulcer; Practice Guidelines as Topic; Publication Bias; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Research Support as Topic; Sulfonamides; Translational Research, Biomedical

2011
Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte.
    Medical science monitor : international medical journal of experimental and clinical research, 2012, Volume: 18, Issue:6

    Topics: Animals; Apoptosis; Cartilage, Articular; Celecoxib; Chondrocytes; Collagen Type II; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Humans; Ibuprofen; Indomethacin; Osteoarthritis; Pyrazoles; Rats; Rats, Wistar; Sulfonamides

2012
Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects.
    Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Celecoxib; Cell Proliferation; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Ibuprofen; Microarray Analysis; Molecular Targeted Therapy; Muscle, Smooth, Vascular; Nitrobenzenes; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides

2012
Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension.
    BMC cardiovascular disorders, 2012, Oct-24, Volume: 12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Celecoxib; Drug Interactions; Female; Humans; Hypertension; Ibuprofen; Indiana; Linear Models; Male; Middle Aged; Naproxen; Odds Ratio; Propensity Score; Pyrazoles; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Treatment Outcome

2012
Celecoxib modifies glomerular basement membrane, mesangium and podocytes in OVE26 mice, but ibuprofen is more detrimental.
    Clinical science (London, England : 1979), 2013, Volume: 124, Issue:11

    Topics: Albumins; Animals; Blood Glucose; Blood Pressure; Celecoxib; Creatinine; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Basement Membrane; Glomerular Mesangium; Ibuprofen; Male; Mice; Mice, Inbred Strains; Podocytes; Prostaglandins; Pyrazoles; Sulfonamides; Transforming Growth Factor beta

2013
Utility of gastric-retained alginate gels to modulate pharmacokinetic profiles in rats.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:8

    Topics: Administration, Oral; Alginates; Animals; Antihypertensive Agents; Celecoxib; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Gastric Mucosa; Gels; Glucuronic Acid; Hexuronic Acids; Ibuprofen; Male; Metoprolol; Permeability; Pyrazoles; Rats; Rats, Sprague-Dawley; Solubility; Sulfonamides

2013
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
    The journal of pain, 2013, Volume: 14, Issue:11

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Ibuprofen; Inflammation; Levetiracetam; Male; Piracetam; Pyrazoles; Rats; Rats, Wistar; Sulfonamides

2013
Do NSAIDs inhibit growth of precancerous cervical cells in vitro?
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2012, Volume: 95 Suppl 1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Celecoxib; Cell Line; Cell Proliferation; Cervix Uteri; Drug Screening Assays, Antitumor; Female; Humans; Ibuprofen; Precancerous Conditions; Pyrazoles; Sulfonamides; Uterine Cervical Neoplasms

2012
More pain for painkillers.
    Time, 2013, Jun-24, Volume: 181, Issue:24

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Naproxen; Pain; Pyrazoles; Risk Factors; Safety-Based Drug Withdrawals; Sulfonamides; United States; United States Food and Drug Administration

2013
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
    Anesthesiology, 2014, Volume: 120, Issue:3

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Celecoxib; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Ibuprofen; Inflammation; Levetiracetam; Male; Pain; Piracetam; Pyrazoles; Rats; Rats, Wistar; Sulfonamides

2014
Effects of aggregation of drug and diagnostic codes on the performance of the high-dimensional propensity score algorithm: an empirical example.
    BMC medical research methodology, 2013, Nov-19, Volume: 13

    Topics: Adolescent; Adult; Aged; Algorithms; Arthritis; Celecoxib; Confounding Factors, Epidemiologic; Cyclooxygenase 2 Inhibitors; Diclofenac; Gastrointestinal Diseases; Hemorrhage; Humans; Ibuprofen; Incidence; Middle Aged; Models, Statistical; Prevalence; Propensity Score; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Treatment Outcome; Young Adult

2013
Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: synthesis and biological studies.
    ChemMedChem, 2014, Volume: 9, Issue:1

    Topics: 4-Chloro-7-nitrobenzofurazan; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fluorescent Dyes; HCT116 Cells; Humans; Ibuprofen; Microscopy, Confocal; Naproxen; Protein Binding; Pyrazoles; Sulfonamides

2014
Potent drugs that attenuate anti-Candida albicans activity of fluconazole and their possible mechanisms of action.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2014, Volume: 20, Issue:10

    Topics: Antifungal Agents; ATP-Binding Cassette Transporters; Candida albicans; Candidiasis; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Fluconazole; Fungal Proteins; Gene Expression; Ibuprofen; Membrane Transport Proteins; Microbial Sensitivity Tests; Omeprazole; Phenylpropionates; Proton Pump Inhibitors

2014
Effects of celecoxib and ibuprofen on metabolic disorders induced by Walker-256 tumor in rats.
    Molecular and cellular biochemistry, 2015, Volume: 399, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cachexia; Carcinoma 256, Walker; Celecoxib; Cell Line, Tumor; Eating; Ibuprofen; Intra-Abdominal Fat; Male; Neoplasm Transplantation; Organ Size; Pyrazoles; Rats, Wistar; Sulfonamides; Weight Loss

2015
NSAID hypersensitivity in twins.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2014, Volume: 25, Issue:8

    Topics: Adolescent; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Celecoxib; Child; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Drug Hypersensitivity; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Ibuprofen; Immunization; Immunoglobulin E; Piroxicam; Pyrazoles; Sulfonamides; Twins; Urticaria

2014
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
    European journal of pain (London, England), 2015, Volume: 19, Issue:10

    Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley

2015
Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 36, Issue:4

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Gluconeogenesis; Ibuprofen; Liver; Male; Neoplasms; Rats; Rats, Wistar

2015
Do Different Cyclooxygenase Inhibitors Impair Rotator Cuff Healing in a Rabbit Model?
    Chinese medical journal, 2015, Sep-05, Volume: 128, Issue:17

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Celecoxib; Cyclooxygenase 2 Inhibitors; Flurbiprofen; Ibuprofen; Male; Rabbits; Rotator Cuff; Tendon Injuries; Wound Healing

2015
Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities.
    Osteoarthritis and cartilage, 2016, Volume: 24, Issue:3

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Comorbidity; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Female; Health Services Research; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Nonprescription Drugs; Osteoarthritis, Knee; Pain; Pain Measurement; Proton Pump Inhibitors; Quality-Adjusted Life Years; Sensitivity and Specificity; Tramadol; Treatment Outcome; United States

2016
Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.
    Bioorganic chemistry, 2016, Volume: 64

    Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Humans; Ibuprofen; Mice; Molecular Docking Simulation; Sheep; Stomach Ulcer; Sulfonamides; Thiazolidines

2016
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
    Behavioural brain research, 2016, Mar-15, Volume: 301

    Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Indomethacin; Inflammation; Male; Morphine; Motor Activity; Nerve Growth Factor; Pain; Rats, Wistar; Tramadol

2016
Identification and modification of amyloid-independent phenotypes of APOE4 mice.
    Experimental neurology, 2016, Volume: 280

    Topics: Age Factors; Alzheimer Disease; Amyloid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apolipoprotein E4; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Dendritic Spines; Disease Models, Animal; Female; Genotype; Humans; Hypoglycemic Agents; Ibuprofen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Phenotype; Pioglitazone; Protein Processing, Post-Translational; Thiazolidinediones

2016
(1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.
    Journal of pharmaceutical and biomedical analysis, 2016, Sep-10, Volume: 129

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; Ibuprofen; Indomethacin; Least-Squares Analysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolomics; Piroxicam; Rats; Rats, Sprague-Dawley

2016
Inflammation: NSAIDs and cardiovascular risk in arthritis.
    Nature reviews. Cardiology, 2017, Volume: 14, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Humans; Ibuprofen; Inflammation; Naproxen; Risk Factors

2017
Therapy: Cardiovascular safety of celecoxib, naproxen and ibuprofen.
    Nature reviews. Rheumatology, 2017, Volume: 13, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Naproxen; Osteoarthritis; Outcome Assessment, Health Care; Safety

2017
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2017, 04-06, Volume: 376, Issue:14

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Humans; Ibuprofen; Naproxen; Pyrazoles; Sulfonamides

2017
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2017, 04-06, Volume: 376, Issue:14

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Humans; Ibuprofen; Naproxen; Pyrazoles; Sulfonamides

2017
NSAIDs for high-risk patients: none, celecoxib, or naproxen?
    Lancet (London, England), 2017, 06-17, Volume: 389, Issue:10087

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Naproxen; Pyrazoles; Sulfonamides

2017
[Cardiovascular safety of celecoxib : Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen (PRECISION)].
    Der Internist, 2017, Volume: 58, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Ibuprofen; Naproxen; Prospective Studies; Pyrazoles; Sulfonamides

2017
Nonsteroidal anti-inflammatory drugs-induced failure of lower esophageal and pyloric sphincter and counteraction of sphincters failure with stable gatric pentadecapeptide BPC 157 in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2017, Volume: 68, Issue:2

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Celecoxib; Diclofenac; Esophageal Sphincter, Lower; Ibuprofen; Male; Peptide Fragments; Pressure; Proteins; Pylorus; Rats, Wistar

2017
Non-inferiority versus superiority drug claims: the (not so) subtle distinction.
    Trials, 2017, 06-15, Volume: 18, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2 Inhibitors; Data Interpretation, Statistical; Drug Approval; Drug Therapy; Equivalence Trials as Topic; Humans; Ibuprofen; Models, Statistical; Naproxen; Research Design; Risk Assessment; Risk Factors; Treatment Outcome

2017
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases.
    Drug design, development and therapy, 2017, Volume: 11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Celecoxib; Cimetidine; Delayed-Action Preparations; Diffusion; Drug Combinations; Drug Compounding; Drug Liberation; Drug Stability; Gastric Juice; Histamine H2 Antagonists; Ibuprofen; Inflammation; Kinetics; Models, Chemical; Nanocapsules; Nanotechnology; Naproxen; Polymers; Solubility; Technology, Pharmaceutical

2017
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.
    Neuropharmacology, 2017, Volume: 125

    Topics: Acetaminophen; Analgesics; Animals; Arthritis; Celecoxib; Disease Models, Animal; Diterpenes; Female; Freund's Adjuvant; Hand Strength; Hyperalgesia; Ibuprofen; Inflammation; Muscle Strength; Nociceptors; Oxycodone; Pain Measurement; Rheumatic Diseases; Ruthenium Red; Tarsus, Animal; Touch; Tramadol; TRPV Cation Channels

2017
The suitability of common compressibility equations for characterizing plasticity of diverse powders.
    International journal of pharmaceutics, 2017, Oct-30, Volume: 532, Issue:1

    Topics: Algorithms; Calcium Phosphates; Celecoxib; Cellulose; Compressive Strength; Excipients; Hardness; Ibuprofen; Lactose; Mannitol; Powders; Stearic Acids

2017
NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for diclofenac, ibuprofen, naproxen, and celecoxib: what are the alternatives?
    Scandinavian journal of pain, 2017, Volume: 16

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Diclofenac; Humans; Ibuprofen; Naproxen; Network Meta-Analysis; Osteoarthritis; Pain

2017
NSAIDs and cardiac arrest: Non-steroidal anti-inflammatory drug use is associated with increased risk of Out-of-hospital Cardiac Arrest: A nationwide Case-Time-Control study.
    European heart journal, 2017, 06-14, Volume: 38, Issue:23

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Celecoxib; Denmark; Humans; Ibuprofen; Lactones; Naproxen; Out-of-Hospital Cardiac Arrest; Risk Factors; Sulfones

2017
Safety of non-steroidal anti-inflammatory drugs.
    European heart journal, 2017, 11-21, Volume: 38, Issue:44

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Celecoxib; Humans; Ibuprofen; Naproxen; Prospective Studies

2017
Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue.
    The Prostate, 2018, Volume: 78, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Celecoxib; Chromatography, Liquid; Comparative Effectiveness Research; Diclofenac; Disease Models, Animal; Ibuprofen; Inflammation; Male; Naproxen; Pelvic Pain; Prostate; Prostatitis; Rats; Rats, Sprague-Dawley; Tissue Distribution

2018
Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:5

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Celecoxib; Cyclooxygenase 2 Inhibitors; Databases, Pharmaceutical; Diclofenac; Female; Hospitalization; Humans; Hypertension; Ibuprofen; Male; Mefenamic Acid; Middle Aged; Naproxen; Risk Factors

2018
Acute pancreatitis with long-term celecoxib vs. ibuprofen or naproxen: data from the PRECISION trial.
    The American journal of gastroenterology, 2018, Volume: 113, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Celecoxib; Humans; Ibuprofen; Naproxen; Pancreatitis; Risk; Taiwan

2018
Effect on Risk of Stroke and Acute Myocardial Infarction of Nonselective Nonsteroidal Anti-Inflammatory Drugs in Patients With Rheumatoid Arthritis.
    The American journal of cardiology, 2018, 05-15, Volume: 121, Issue:10

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Diclofenac; Female; Humans; Ibuprofen; Logistic Models; Male; Mefenamic Acid; Meloxicam; Middle Aged; Myocardial Infarction; Odds Ratio; Risk Factors; Stroke

2018
Modulating Sticking Propensity of Pharmaceuticals Through Excipient Selection in a Direct Compression Tablet Formulation.
    Pharmaceutical research, 2018, Mar-30, Volume: 35, Issue:6

    Topics: Adhesiveness; Celecoxib; Drug Compounding; Excipients; Ibuprofen; Powders; Tablets

2018
The Aspirin-NSAID Interaction: More Data, But a Lack of Clarity Remains.
    Journal of the American College of Cardiology, 2018, 04-24, Volume: 71, Issue:16

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Ibuprofen; Naproxen

2018
Editorial: gastrointestinal safety of COX-2 selective and nonselective NSAIDs-the impact of the PRECISION trial.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Naproxen

2018
Editorial: gastrointestinal safety of COX-2 selective and nonselective NSAIDs-the impact of the PRECISION trial. Authors' reply.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Naproxen

2018
NSAID choice: lessons from PRECISION.
    Aging, 2019, 04-29, Volume: 11, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Humans; Ibuprofen; Naproxen; Pain; Treatment Outcome

2019
Danger of highlighting the use of coxibs in daily dental practice.
    International journal of oral and maxillofacial surgery, 2019, Volume: 48, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Molar, Third; Pain, Postoperative

2019
In response to Letter to the Editor "Danger of highlighting the use of coxibs in daily dental practice".
    International journal of oral and maxillofacial surgery, 2019, Volume: 48, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Molar, Third; Pain, Postoperative

2019
Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate
    Communications biology, 2019, Volume: 2

    Topics: Adoptive Transfer; Aerosols; Animals; Bacterial Load; Celecoxib; Cell Differentiation; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Disease Progression; Female; Host-Pathogen Interactions; Ibuprofen; Inhalation Exposure; Interferon-gamma; Lung; Lymphocyte Activation; Mice, Inbred C3H; Mycobacterium tuberculosis; Th1 Cells; Tuberculosis, Pulmonary

2019
Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice.
    Journal of complementary & integrative medicine, 2019, Aug-15, Volume: 17, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Depression; Disease Models, Animal; Exercise Test; Ibuprofen; Indomethacin; Interferon-alpha; Male; Mice

2019
A comprehensive model for pain management in patients undergoing pelvic reconstructive surgery: a prospective clinical practice study.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:2

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Enhanced Recovery After Surgery; Female; Gabapentin; Gynecologic Surgical Procedures; Humans; Ibuprofen; Middle Aged; Oxycodone; Pain Management; Pain, Postoperative; Pelvic Organ Prolapse; Perioperative Care; Plastic Surgery Procedures; Prospective Studies

2020
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
    Behavioural pharmacology, 2021, 04-01, Volume: 32, Issue:2&3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Ibuprofen; Inflammation; Ketoprofen; Male; Pain; Rats; Rats, Sprague-Dawley; Sex Factors

2021
Hydrophilic polymer driven crystallization self-assembly: an inflammatory multi-drug combination nanosystem against Alzheimer's disease.
    Journal of materials chemistry. B, 2021, 10-13, Volume: 9, Issue:39

    Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Celecoxib; Cell Line; Crystallization; Drug Design; Humans; Ibuprofen; Male; Mice; Micelles; Molecular Structure; Nanostructures; Neuroinflammatory Diseases; Polymers; Telmisartan

2021
NSAIDs affect dendritic cell cytokine production.
    PloS one, 2022, Volume: 17, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Neoplasm; CD8-Positive T-Lymphocytes; Celecoxib; Cytokines; Dendritic Cells; Diclofenac; Humans; Ibuprofen; Mice; Neoplasms

2022