ibuprofen and capsaicin

ibuprofen has been researched along with capsaicin in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (15.38)18.2507
2000's9 (34.62)29.6817
2010's11 (42.31)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
Backlund, A; Bohlin, L; Gottfries, J; Larsson, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Gao, J; Guo, Y; Hu, X; Huang, H; Jin, Z; Li, Z; Liu, Z; Wang, K; Wang, Y; Zhang, L; Zhong, Y; Zong, X1
Brune, K; Forster, C; Geisslinger, G; Handwerker, HO; Kilo, S1
Cruwys, SC; Kidd, BL; Morris, VH1
Michael, LR; Southall, DM; Vasko, RM1
Dirig, DM; Yaksh, TL1
Chen, HF; Kou, YR1
Kidd, BL; McCormack, K; Morris, V1
Cho, H; Kim, MS; Koo, J; Oh, U; Shim, WS; Yang, YD1
Jones, CK; Peters, SC; Shannon, HE1
Cadiou, H; Jones, NG; McMahon, SB; McNaughton, P; Slater, R1
Beaulieu, P; De Léan, A; Guindon, J; LoVerme, J; Piomelli, D1
Antigny, F; Auzanneau, C; Becq, F; Cantereau, A; Jougla, C; Norez, C; Thoreau, V; Vandebrouck, C1
Brain, SD; Helyes, Z; Perkecz, A; Pintér, E; Pozsgai, G; Sándor, K; Szolcsányi, J1
Bennett, SM; Hayes, JE1
Galluzzi, KE; Stanos, SP1
Abbasnejad, M; Amirkhosravi, L; Esmaeili-Mahani, S; Kooshki, R; Rafie, F; Raoof, M; Raoof, R; Sheibani, V1
Abbasnejad, M; Amirkhosravi, L; Esmaeili-Mahani, S; Haghani, J; Hajializadeh, Z; Nourzadeh, M; Rafie, F; Raoof, M; Raoof, R1
Andersson, J; Kong, Y; Mezue, M; Tracey, I; Wanigasekera, V1
Fu, M; Huang, W; Pan, M; Qian, H; Wang, J; Yan, L1
Doherty, M; Fernandes, G; Persson, MSM; Sarmanova, A; Stocks, J; Walsh, DA; Zhang, W1

Reviews

1 review(s) available for ibuprofen and capsaicin

ArticleYear
Topical therapies in the management of chronic pain.
    Postgraduate medicine, 2013, Volume: 125, Issue:4 Suppl 1

    Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chronic Pain; Diclofenac; Humans; Ibuprofen; Irritants; Ketoprofen; Lidocaine; Musculoskeletal Pain; Neoplasms; Neuralgia; Neuralgia, Postherpetic; Osteoarthritis, Knee; Palliative Care

2013

Trials

5 trial(s) available for ibuprofen and capsaicin

ArticleYear
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man.
    Pain, 1995, Volume: 62, Issue:2

    Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Dermatitis; Double-Blind Method; Female; Freezing; Humans; Hyperalgesia; Ibuprofen; Male; Skin; Stress, Mechanical; Treatment Outcome

1995
Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis.
    Pain, 1997, Volume: 71, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hyperalgesia; Ibuprofen; Male; Nociceptors; Pain Measurement; Pain Threshold; Skin Temperature

1997
Assay of topically administered ibuprofen using a model of post-injury hypersensitivity. A randomised, double-blind, placebo-controlled study.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:6-7

    Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dermatitis, Contact; Double-Blind Method; Gels; Hot Temperature; Humans; Ibuprofen; Physical Stimulation; Pilot Projects; Temperature

2000
Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development.
    Anesthesiology, 2016, Volume: 124, Issue:1

    Topics: Adult; Amines; Analgesics; Analgesics, Non-Narcotic; Brain; Capsaicin; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Ibuprofen; Magnetic Resonance Imaging; Male; Neuroimaging; Reproducibility of Results; Treatment Outcome; Young Adult

2016
Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials.
    Rheumatology (Oxford, England), 2021, 05-14, Volume: 60, Issue:5

    Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Treatment Outcome

2021

Other Studies

20 other study(ies) available for ibuprofen and capsaicin

ArticleYear
Expanding the ChemGPS chemical space with natural products.
    Journal of natural products, 2005, Volume: 68, Issue:7

    Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship

2005
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Analgesics; Animals; Anoctamin-1; Carboxylic Acids; HEK293 Cells; Humans; Hyperalgesia; Mice; Neoplasm Proteins; Pain

2022
Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.
    Pain, 1998, Volume: 78, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclooxygenase Inhibitors; Freund's Adjuvant; Hyperalgesia; Ibuprofen; In Vitro Techniques; Injections, Spinal; Ketorolac; Male; Myelitis; Neuropeptides; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tolmetin

1998
In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capsaicin; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Ibuprofen; In Vitro Techniques; Inflammation; Knee Joint; Male; N-Methylaspartate; Prostaglandins; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Thromboxane B2

1999
Vagal and mediator mechanisms underlying the tachypnea caused by pulmonary air embolism in dogs.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 88, Issue:4

    Topics: Animals; Capsaicin; Dogs; Embolism, Air; Female; Free Radical Scavengers; Ibuprofen; Male; Nerve Fibers; Pulmonary Embolism; Respiratory Mechanics; Thiourea; Tidal Volume; Time Factors; Vagus Nerve

2000
Calcium-activated cationic channel in rat sensory neurons.
    The European journal of neuroscience, 2003, Volume: 17, Issue:12

    Topics: Adenine Nucleotides; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Calcium Channel Blockers; Capsaicin; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Conductivity; Extracellular Space; Ganglia, Spinal; Ibuprofen; Ion Channels; Membrane Potentials; Neurons, Afferent; ortho-Aminobenzoates; Patch-Clamp Techniques; Rats; Receptors, Drug

2003
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes

2005
Acid-induced pain and its modulation in humans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Dec-01, Volume: 24, Issue:48

    Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Female; Forearm; Hot Temperature; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Hyperalgesia; Ibuprofen; Injections, Subcutaneous; Ion Channels; Iontophoresis; Male; Membrane Proteins; Middle Aged; Nerve Tissue Proteins; Pain; Pain Measurement; Pain Threshold; Refractory Period, Electrophysiological; Single-Blind Method; Sodium Channels; TRPV Cation Channels

2004
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
    European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Edema; Endocannabinoids; Formaldehyde; Ibuprofen; Lactones; Male; Mass Spectrometry; Nitrobenzenes; Pain Measurement; Peripheral Nervous System; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sulfonamides; Sulfones; TRPV Cation Channels

2006
Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.
    Biochemical pharmacology, 2008, Jan-15, Volume: 75, Issue:2

    Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Chloride Channels; Hydrogen-Ion Concentration; Ibuprofen; Male; Rats; Rats, Wistar; Sertoli Cells; TRPV Cation Channels

2008
Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2007, Volume: 56, Issue:11

    Topics: Acetone; Administration, Cutaneous; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Capsaicin; Diterpenes; Drug Synergism; Ear; Edema; Ibuprofen; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Sensory Receptor Cells; Tetradecanoylphorbol Acetate; TRPV Cation Channels

2007
Differences in the chemesthetic subqualities of capsaicin, ibuprofen, and olive oil.
    Chemical senses, 2012, Volume: 37, Issue:5

    Topics: Adolescent; Adult; Aldehydes; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Calcium Channels; Capsaicin; Cyclopentane Monoterpenes; Female; Humans; Ibuprofen; Male; Middle Aged; Nerve Tissue Proteins; Olive Oil; Phenols; Plant Oils; Taste; Taste Perception; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2012
Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats.
    Neuropeptides, 2015, Volume: 50

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Capsaicin; Dental Pulp; Hippocampus; Ibuprofen; Incisor; Learning Disabilities; Male; Maze Learning; Memory Disorders; Naphthyridines; Nerve Tissue Proteins; Nociception; Orexin Receptors; Orexins; Pain Measurement; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Single-Blind Method; Toothache; Urea

2015
[Shingles symptoms are gone but not the pain].
    MMW Fortschritte der Medizin, 2015, Jul-23, Volume: 157, Issue:13

    Topics: Administration, Cutaneous; Administration, Oral; Aged; Amines; Amitriptyline; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclohexanecarboxylic Acids; Dipyrone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Guideline Adherence; Humans; Ibuprofen; Lidocaine; Neuralgia, Postherpetic; Phenols; Pregabalin; Tapentadol; Treatment Failure

2015
Noxious Stimulation of the Rat Tooth Pulp May Impair Learning and Memory Through the Induction of Hippocampal Apoptosis.
    Journal of oral & facial pain and headache, 2015,Fall, Volume: 29, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Capsaicin; Caspase 3; Dental Pulp; Hippocampus; Ibuprofen; Learning Disabilities; Male; Maze Learning; Memory; Memory Disorders; Nociception; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Wistar; Sensory System Agents; Spatial Learning; Time Factors

2015
Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1.
    Bioorganic & medicinal chemistry, 2016, Feb-15, Volume: 24, Issue:4

    Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Body Temperature; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Diamines; Drug Design; Gene Expression; Humans; Ibuprofen; Male; Mice; Nociception; Pain; Piperazines; Recombinant Proteins; Sheep; Structure-Activity Relationship; TRPV Cation Channels

2016