ibuprofen and arachidonic acid

ibuprofen has been researched along with arachidonic acid in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	47 (42.34)	18.7374
1990's	33 (29.73)	18.2507
2000's	23 (20.72)	29.6817
2010's	7 (6.31)	24.3611
2020's	1 (0.90)	2.80

Authors

Authors	Studies
Bohlin, L; Danielson, H; Noreen, Y; Perera, P; Ringbom, T	1
Simmet, T; Tschorn, K; Weide, I	1
Bonnet, P; Bourdeau, A; Herviaux, P; Lieberherr, M; Sachs, C; Souberbielle, JC	1
Deyrup-Olsen, I; Louie, H; Luchtel, DL; Martin, AW	1
Badr, KF; Capdevila, J; Falck, JR; Jacobson, HR; Karara, A; Takahashi, K	1
Fritz, ME; Green, MD; Mayambala, CS; Odle, BM; Offenbacher, S; Sena, FJ; Smith, MA; van Dyke, TE; Yeh, KC	1
Alyea, EP; Bernier, M; Hearse, DJ	1
Badr, KF; Harris, RC; Munger, KA; Takahashi, K	1
Hellewell, PG; Williams, TJ; Yarwood, H	1
Clark, CL; Taylor, MJ	1
Easom, RA; Hughes, JH; McDaniel, ML; Turk, J; Wolf, BA	1
Barman, SA; Senteno, E; Smith, S; Taylor, AE	1
Bennett, A; Capasso, F; Tavares, IA; Vine, ND	1
Ishac, EJ; Kunos, G	1
Kothari, HV; Ku, EC; Lee, W; Scholer, DW	1
Cheng, HY; Donowitz, M; Sharp, GW	1
Dorman, RV; Schwartz, MA; Terrian, DM	1
Needleman, P; Tripp, CS; Unanue, ER; Wyche, A	1
Fuhrman, TM; Halushka, PV; Hollon, MF; Olanoff, LS; Reines, HD	1
Kim, SD; Marshall, BE; Marshall, C	1
Griswold, DE; Hanna, N; Schwartz, L; Webb, E	1
Karmazyn, M	1
Patterson, CE; Rhoades, RA; Selig, WM	1
Wallenstein, MC	1
Baxter, CS; Lawrence, AT	1
Lang, SA; Maron, MB	1
Karmali, RA	1
Bischoff, SB; Dorman, RV; Schwartz, MA; Terrian, DM	1
Anderson, WP; Bobik, A	1
Brune, K; Reinke, M	1
DiMartino, MJ; Griswold, DE; Hanna, N; Hillegass, LM; Meunier, PC	1
Rao, GH; White, JG	1
Bar, RS; Dolash, S; Kaduce, TL; Marshall, SJ; Sandra, A; Spector, AA	1
Odessey, R	1
Ferrier, GR; Karmazyn, M; Moffat, MP	1
Butler, WR; Figueroa, JP; Grandis, A; Handwerger, S; Huyler, SE; Mann, C; Mitchell, M; Nathanielsz, PW	1
Fuller, BL; Rosenthale, ME; Tolman, EL	1
Radha, E; Rao, GH; White, JG	1
Dizerega, GS; Nakamura, RM; Shimanuki, T	2
Kimble, EF; Kothari, HV; Ku, EC; Lee, W; Liauw, L; Tjan, J	1
Kimble, EF; Kothari, H; Ku, EC; Lee, W; Liauw, LH	1
Anderson, RJ; Gerber, JG; Nies, AS; Schrier, RW	1
Fujimoto, W; Little, S; Metz, SA; Robertson, RP	1
Burke, SE; Lefer, AM; Roth, DM	1
Lefer, AM; Lefer, BL; Reibel, DK; Roth, DM	1
Pappius, HM; Wolfe, LS	1
Brotherton, AF; Hoak, JC	1
Hoak, JC	1
Bailey, JM; Vanderhoek, JY	1
diZerega, GS; Nishimura, K; Shimanuki, T	1
Bone, RC; Jacobs, ER	1
Goodwin, JS	1
Holingsworth, EB; Patrick, GA	1
Metz, SA	1
Chatterjee, S; Johnson, DC	1
Elks, ML	1
Curi, R; de Bittencourt Júnior, PI; Hirata, MH; Williams, JF; Yano, MM	1
Damron, DS; Dorman, RV	1
Altman, JD; Bache, RJ	1
Hartupee, DA; Jimenez, A; Passmore, JC	1
Bhattacharyya, DK; Garavito, M; Lecomte, M; Rieke, CJ; Smith, WL	1
Gonchar, MV; Grishina, ZV; Mevkh, AT; Sergeeva, MG; Varfolomeyev, SD	1
Mue, S; Ohuchi, K; Watanabe, M; Yamada, M	1
Crews, BC; Kalgutkar, AS; Marnett, LJ	1
Bancalari, E; Flynn, J; Quero, J; Stiris, TA; Suguihara, C	1
Cromlish, W; Ethier, D; Evans, JF; Falgueyret, JP; Francis, DA; Greig, GM; Kargman, S; Kennedy, B; O'Neill, GP; Riendeau, D; Tagari, P; Wong, E; Yergey, JA	1
Furukawa, M; Nakatsugi, S; Sugimoto, N	1
Belzer, FO; Saunder, A; Schilling, M; Southard, JH	1
Warashina, A	1
Barnett, J; Mak, AY; Ramesha, CS; Swinney, DC	1
Amano, F; Kawaguchi, M; Takahashi, M; Tanaka, Y	1
Ghosh, J; Myers, CE	1
Cordella-Miele, E; Frizzell, R; Miele, L; Mukherjee, AB; Xing, M	1
Gonchar, MV; Mevkh, AT; Namgaladze, DA; Sergeeva, MG; Varfolomeyev, SD	1
Angel, I; Arbilla, S; Pichat, P	1
Forghani, F; Keen, S; Ouellet, M; Percival, MD; Tagari, P	1
Dahlén, SE; Kumlin, M; Mueller, MJ; O'Sullivan, S	1
Langenbach, R; Morham, SG; Young, DA; Zhang, X	1
Abel, S; Gelderblom, WC; Smuts, CM; Snyman, SD; Swanevelder, S	1
Catisti, R; Docampo, R; Uyemura, SA; Vercesi, AE	1
Lakkides, KM; Smith, WL; Thuresson, ED	1
Cuppoletti, J; Malinowska, DH; Sherry, AM; Tewari, KP	1
Attiga, FA; Fernandez, PM; Manyak, MJ; Patierno, SR; Weeraratna, AT	1
Danon, A; Rimon, G; Rosenstock, M; Rubin, M	1
Golub, MS; Hori, MT; Kanda, H; Tuck, ML	1
Murray, PA; Ogawa, K; Tanaka, S	1
Kim, JM; Manchanda, R; Tsang, BK	1
Guild, SB	1
Castonguay, A; Miller, MS; Schuller, HM; Walker, K; Weddle, DL; Zhang, L	1
Burde, T; Rimon, G	1
Kent, JD; Leese, PT; Recker, DP	1
Barnard, MR; Frelinger, AL; Laposata, M; Linden, MD; Michelson, AD; Morris, JE; O'Sullivan, BP; Salem, RO; Spencer-Manzon, M	1
Bresee, SJ; Carroll, RC; Chavez, JJ; Cohen, E; Craft, RM; Snider, CC	1
Albano, RM; Assis, MC; Bozza, PT; Coelho, MG; Gayer, CR; Lopes, UG; Marques, EA; Nascimento, DO; Paiva, DD; Plotkowski, MC; Raymond, B; Saliba, AM; Silva, MC; Touqui, L	1
Groneberg, DA; Schmidt, R; Staats, P; Wagner, U	1
Capone, ML; D'Amelio, E; De Caterina, R; Grana, M; Patrignani, P; Patrono, C; Price, TS; Renda, G; Sacchetta, D; Santarelli, F; Sciulli, MG; Tacconelli, S; Zimarino, M; Zurro, M	1
Martin, BR; Razdan, RK; Wiley, JL	1
Blanzat, M; Bordat, P; Consola, S; Garrigues, JC; Perez, E; Rico-Lattes, I	1
Anghelescu, M; Frost, JR; Hamanaka, K; King, JA; Miyahara, T; Parker, JC; Weber, DS	1
Bates, VE; Gengo, FM; Hong, Y; Mager, DE; Rainka, MM	1
Kulmacz, RJ; Lichtenberger, LM; Rand Doyen, J; Yucer, N	1
Duggan, KC; Marnett, LJ; Prusakiewicz, JJ; Rouzer, CA	1
Bhandari, K; Venables, B	1
Ilatovskaya, DV; Levchenko, V; Mattson, DL; Pavlov, TS; Roman, RJ; Staruschenko, A	1
Altavilla, D; Bitto, A; Burnett, BP; Levy, RM; Pillai, L; Squadrito, F	1
Alcay, S; Altinbas, B; Erkan, LG; Guvenc, G; Toker, MB; Udum Kucuksen, D; Ustuner, B; Yalcin, M	1
Altinbas, B; Erkan, LG; Guvenc, G; Niaz, N; Yalcin, M	1
Dong, L; Hong, YH; Murphy, RC; Smith, WL; Uhlson, CL; Yuan, C; Zou, H	1
Adler, N; Fuhrmann, H; Schoeniger, A	1
Barceló, D; López-Doval, JC; Rodríguez-Mozaz, S; Sabater, S; Serra-Compte, A	1

Reviews

4 review(s) available for ibuprofen and arachidonic acid

Article	Year
Prostaglandins and the regulation of renal circulation and function. Advances in prostaglandin, thromboxane, and leukotriene research, 1982, Volume: 10 Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Body Water; Glomerular Filtration Rate; Humans; Ibuprofen; Indomethacin; Kidney; Liver Cirrhosis, Alcoholic; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Regional Blood Flow; Vasodilation	1982
Mechanisms of action: aspirin. Thrombosis research. Supplement, 1983, Volume: 4 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Endothelium; Humans; Ibuprofen; In Vitro Techniques; Indomethacin; Salicylates; Salicylic Acid; Thromboxanes	1983
Mechanism of action of nonsteroidal anti-inflammatory agents. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Carbazoles; Cell Movement; Cyclooxygenase Inhibitors; Gastritis; Humans; Ibuprofen; Immunoglobulin M; Indomethacin; Lymphocytes; Neutrophils; Piroxicam; Prostaglandin Antagonists; Prostaglandins E; Rheumatoid Factor; Thiazines	1984
Anti-inflammatory agents as inhibitors of prostaglandin synthesis in man. The Medical clinics of North America, 1981, Volume: 65, Issue:4 Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Drug Interactions; Female; Humans; Ibuprofen; Indomethacin; Inflammation; Kinetics; Male; Prostaglandin Antagonists; Prostaglandins; Prostaglandins E; Prostaglandins F; Salicylates; Sex Factors	1981

Trials

3 trial(s) available for ibuprofen and arachidonic acid

Article	Year
The COX-2 selective inhibitor, valdecoxib, does not impair platelet function in the elderly: results of a randomized controlled trial. Journal of clinical pharmacology, 2003, Volume: 43, Issue:5 Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Arachidonic Acid; Bleeding Time; Blood Platelets; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Ibuprofen; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane B2	2003
Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3 Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Celecoxib; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ibuprofen; Male; Middle Aged; Myocardial Ischemia; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrazoles; Sulfonamides; Thromboxane B2; Treatment Outcome	2006
Population pharmacodynamic modelling of aspirin- and Ibuprofen-induced inhibition of platelet aggregation in healthy subjects. Clinical pharmacokinetics, 2008, Volume: 47, Issue:2 Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Collagen; Cross-Over Studies; Cyclooxygenase Inhibitors; Half-Life; Humans; Ibuprofen; Middle Aged; Models, Biological; Monte Carlo Method; Platelet Aggregation; Platelet Aggregation Inhibitors; Single-Blind Method; Time Factors	2008

Other Studies

104 other study(ies) available for ibuprofen and arachidonic acid

Article	Year
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. Journal of natural products, 1998, Volume: 61, Issue:1 Topics: Animals; Biological Assay; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Kinetics; Placenta; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sheep	1998
Effects of cyclooxygenase inhibitors on ex vivo cysteinyl-leukotriene production by whole human blood allowed to clot spontaneously. Comparison to stimulated blood. Thrombosis research, 1992, Jul-01, Volume: 67, Issue:1 Topics: Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Blood Coagulation; Calcimycin; Cyclooxygenase Inhibitors; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Ibuprofen; Leukotrienes; Male; N-Formylmethionine Leucyl-Phenylalanine; Thromboxane B2	1992
Phospholipase-A2 action and arachidonic acid metabolism in calcium-mediated parathyroid hormone secretion. Endocrinology, 1992, Volume: 130, Issue:3 Topics: Acetophenones; Animals; Arachidonic Acid; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Flavanones; Flavonoids; Ibuprofen; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Parathyroid Glands; Parathyroid Hormone; Phospholipases A; Phospholipases A2; Pyrazoles; Quinacrine; Swine; Time Factors; Tritium	1992
Triggering by ATP of product release by mucous granules of the land slug Ariolimax columbianus. The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 1 Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcimycin; Cytoplasmic Granules; Dinoprostone; Electric Stimulation; Ethylmaleimide; Furosemide; Ibuprofen; Indomethacin; Kinetics; Microscopy, Electron; Mollusca; Mucous Membrane; Nigericin; Pertussis Toxin; Tetradecanoylphorbol Acetate; Verapamil; Virulence Factors, Bordetella	1992
Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. The American journal of physiology, 1990, Volume: 258, Issue:4 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cytochrome P-450 Enzyme System; Hemodynamics; Ibuprofen; Kidney; Male; Rats; Rats, Inbred Strains	1990
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents. Agents and actions, 1990, Volume: 29, Issue:3-4 Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Eicosapentaenoic Acid; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Meclofenamic Acid; Naproxen; Periodontitis; Periodontium; Vitamin E	1990
Reperfusion-induced arrhythmias are not prevented by ibuprofen in isolated rat heart. Free radical biology & medicine, 1990, Volume: 8, Issue:6 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; Coronary Circulation; Cyclooxygenase Inhibitors; Free Radicals; Heart Rate; Ibuprofen; In Vitro Techniques; Indomethacin; Male; Myocardial Reperfusion Injury; Rats; Rats, Inbred Strains; Reperfusion	1990
Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1990, Apr-01, Volume: 4, Issue:6 Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Epidermal Growth Factor; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Ibuprofen; Ketoconazole; Kidney; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Regional Blood Flow	1990
Characteristics of oedema formation induced by N-formyl-methionyl-leucyl-phenylalanine in rabbit skin. British journal of pharmacology, 1989, Volume: 97, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Colchicine; Dinoprostone; Edema; Endotoxins; Histamine; Ibuprofen; Male; N-Formylmethionine Leucyl-Phenylalanine; Rabbits; Skin Diseases; Zymosan	1989
Analysis of relaxin release by cultured porcine luteal cells using a reverse hemolytic plaque assay: effects of arachidonic acid, cyclo- and lipooxygenase blockers, phospholipase A2, and melittin. Endocrinology, 1989, Volume: 125, Issue:3 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bee Venoms; Cells, Cultured; Corpus Luteum; Cyclooxygenase Inhibitors; Dinoprostone; Female; Hemolytic Plaque Technique; Ibuprofen; Kinetics; Lipoxygenase Inhibitors; Melitten; Phospholipases; Phospholipases A; Phospholipases A2; Relaxin; Swine	1989
Interleukin 1-induced prostaglandin E2 accumulation by isolated pancreatic islets. Diabetes, 1989, Volume: 38, Issue:10 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Glucose; Glycolysis; Ibuprofen; In Vitro Techniques; Indomethacin; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Kinetics; Male; Rats; Rats, Inbred Strains; Recombinant Proteins	1989
Acetylcholine's effect on vascular resistance and compliance in the pulmonary circulation. Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 67, Issue:4 Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Dogs; Endothelium, Vascular; Female; Ibuprofen; Lung; Male; Methylene Blue; Nitric Oxide; Pulmonary Circulation; Pyrazoles; Vascular Resistance; Vasodilation	1989
Effects of isoxicam and other non-steroidal anti-inflammatory drugs on arachidonic acid metabolism by rat peritoneal leucocytes. The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Calcimycin; Hydroxyeicosatetraenoic Acids; Ibuprofen; In Vitro Techniques; Indomethacin; Leukocytes; Male; Naproxen; Piroxicam; Prostaglandins; Rats; Rats, Inbred Strains; Thiazines	1985
An arachidonate metabolite is involved in the conversion from alpha 1- to beta-adrenergic glycogenolysis in isolated rat liver cells. Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Dactinomycin; Epinephrine; Fatty Acids; Glycogen; Ibuprofen; Isoproterenol; Liver; Male; Masoprocol; Phenylephrine; Phospholipases A; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta	1986
Effect of diclofenac sodium on the arachidonic acid cascade. The American journal of medicine, 1986, Apr-28, Volume: 80, Issue:4B Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Leukocytes; Lipoxygenase Inhibitors; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Naproxen; Phospholipids; Piroxicam; Prostaglandins E; Rats; SRS-A; Thiazines; Triglycerides	1986
Effects of phorbol esters on sodium and chloride transport in rat colon. The American journal of physiology, 1986, Volume: 251, Issue:4 Pt 1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Chlorides; Colon; Ibuprofen; Indomethacin; Intestinal Absorption; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium; Tetrodotoxin; Verapamil	1986
Prostaglandin involvement in the evoked release of D-aspartate from cerebellar mossy fiber terminals. Brain research bulletin, 1986, Volume: 17, Issue:2 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Biological Transport; Cerebellum; Dinoprost; Dinoprostone; Ibuprofen; Indomethacin; Kinetics; Potassium; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Stereoisomerism; Tetrodotoxin; Verapamil	1986
The functional significance of the regulation of macrophage Ia expression by endogenous arachidonate metabolites in vitro. Journal of immunology (Baltimore, Md. : 1950), 1986, Dec-15, Volume: 137, Issue:12 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Female; Histocompatibility Antigens Class II; Ibuprofen; Indomethacin; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Prostaglandins E; SRS-A; Thromboxanes	1986
Beneficial effects of ibuprofen in oleic acid induced lung injury. The Journal of surgical research, 1987, Volume: 42, Issue:3 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dogs; Extracellular Space; Hemodynamics; Ibuprofen; Lung; Lung Diseases; Methylprednisolone; Oleic Acid; Oleic Acids; Vascular Resistance	1987
The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction. Anesthesiology, 1987, Volume: 66, Issue:4 Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Drug Interactions; Female; Halothane; Hypoxia; Ibuprofen; Lipoxygenase Inhibitors; Pulmonary Circulation; Pyrazoles; Rats; Rats, Inbred Strains; Vasoconstriction	1987
Arachidonic acid-induced inflammation: inhibition by dual inhibitor of arachidonic acid metabolism, SK&F 86002. Inflammation, 1987, Volume: 11, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Ibuprofen; Imidazoles; Inflammation; Male; Masoprocol; Mice; Mice, Inbred BALB C; Naproxen; Peritonitis; Piroxicam; Pyrazoles; Thiazoles	1987
Calcium paradox-evoked release of prostacyclin and immunoreactive leukotriene C4 from rat and guinea-pig hearts. Evidence that endogenous prostaglandins inhibit leukotriene biosynthesis. Journal of molecular and cellular cardiology, 1987, Volume: 19, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Epoprostenol; Guinea Pigs; Heart; Ibuprofen; In Vitro Techniques; Male; Myocardial Contraction; Perfusion; Rats; Rats, Inbred Strains; SRS-A	1987
Cyclooxygenase metabolites contribute to oleic acid-induced lung edema by a pressure effect. Experimental lung research, 1987, Volume: 13, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Guinea Pigs; Ibuprofen; In Vitro Techniques; Male; Oleic Acid; Oleic Acids; Pressure; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pulmonary Circulation; Pulmonary Edema; SRS-A	1987
Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs. Experimental neurology, 1987, Volume: 98, Issue:1 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Epilepsy; Female; Ibuprofen; Mefenamic Acid; Penicillins; Prostaglandins; Rats; Rats, Inbred Strains; Thromboxanes	1987
Specific inhibition of phorbol diester-induced granulocyte-macrophage progenitor cell (GM-CFU) differentiation by lipoxygenase inhibitors. Cancer letters, 1987, Volume: 37, Issue:3 Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Butylated Hydroxyanisole; Cell Differentiation; Colony-Forming Units Assay; Dexamethasone; Granulocytes; Hematopoietic Stem Cells; Ibuprofen; Indomethacin; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Tetradecanoylphorbol Acetate	1987
Role of prostaglandins in blood-induced vasoconstriction of canine cerebral arteries. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1988, Volume: 8, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood; Cerebral Arteries; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Dogs; Female; Ibuprofen; Indomethacin; Male; Meclofenamic Acid; Papaverine; Prostaglandins; Prostaglandins E; Prostaglandins F; Vasoconstriction	1988
Modulation of arachidonic acid metabolism in experimental arthritis induced by Salmonella enteritidis. I. Effect of ibuprofen and flurbiprofen on experimental arthritis induced by Salmonella enteritidis. Prostaglandins, leukotrienes, and medicine, 1987, Volume: 29, Issue:2-3 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Infectious; Flurbiprofen; Ibuprofen; Male; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salmonella enteritidis; Salmonella Infections	1987
Molecular mechanisms of acidic amino acid release from mossy fiber terminals of rat cerebellum. Advances in experimental medicine and biology, 1987, Volume: 221 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Biological Transport; Cerebellar Cortex; Fatty Acids, Nonesterified; Ibuprofen; Indomethacin; Kinetics; Male; Potassium; Rats	1987
Effects of five non-steroidal anti-inflammatory drugs on the renal and systemic responses to arachidonate in conscious dogs. Clinical and experimental pharmacology & physiology, 1987, Volume: 14, Issue:8 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprostone; Dogs; Ibuprofen; Indomethacin; Kidney; Kidney Cortex; Microsomes; Phenylbutazone; Prostaglandins; Prostaglandins E; Sulindac	1987
A monoclonal anti-thromboxane B2 antibody. FEBS letters, 1988, May-09, Volume: 232, Issue:1 Topics: Animals; Antibodies, Monoclonal; Antibody Affinity; Antibody Specificity; Arachidonic Acid; Arachidonic Acids; Humans; Ibuprofen; Imidazoles; Immunoglobulin G; Indomethacin; Mice; Mice, Inbred BALB C; Platelet Aggregation; Radioimmunoassay; Thromboxane A2; Thromboxane B2	1988
Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis. Arthritis and rheumatism, 1988, Volume: 31, Issue:11 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis; Collagen; Dexamethasone; Ibuprofen; Imidazoles; Male; Mice; Mice, Inbred DBA; Pyrazoles; Serum Amyloid P-Component; Thiazoles	1988
Comparative pharmacology of cyclooxygenase inhibitors on platelet function. Prostaglandins, leukotrienes, and medicine, 1985, Volume: 18, Issue:1 Topics: 2,2'-Dipyridyl; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Docosahexaenoic Acids; Fatty Acids, Unsaturated; Heme; Humans; Ibuprofen; Iron; Platelet Aggregation	1985
Morphological alterations in cultured endothelial cells induced by arachidonic acid. Experimental cell research, 1985, Volume: 158, Issue:2 Topics: Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; Dinoprostone; Dose-Response Relationship, Drug; Endothelium; Fatty Acids; Female; Ibuprofen; Indomethacin; Kinetics; Male; Phospholipids; Prostaglandins E; Pulmonary Artery; SRS-A; Time Factors	1985
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown. Metabolism: clinical and experimental, 1985, Volume: 34, Issue:7 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniques; Indomethacin; Leupeptins; Lysosomes; Muscles; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Proteins; Quinacrine; Rats; Rats, Inbred Strains; Tyrosine	1985
Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain. The American journal of physiology, 1985, Volume: 249, Issue:1 Pt 2 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; Aspirin; Coronary Circulation; Coronary Disease; Coronary Vessels; Dinoprost; Dinoprostone; Epoprostenol; Guinea Pigs; Ibuprofen; Indomethacin; Ligation; Male; Ouabain; Perfusion; Prostaglandins; Prostaglandins E; Prostaglandins F; Time Factors	1985
Stimulation of ovine placental lactogen secretion by arachidonic acid. The Journal of endocrinology, 1985, Volume: 106, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Female; Fetal Blood; Gestational Age; Ibuprofen; Indomethacin; Placenta; Placental Lactogen; Pregnancy; Progesterone; Sheep; Stimulation, Chemical	1985
Potent and selective effects of suprofen on uterine prostaglandin synthesis. Prostaglandins, leukotrienes, and medicine, 1985, Volume: 18, Issue:3 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dysmenorrhea; Female; Guinea Pigs; Ibuprofen; Phenylpropionates; Prostaglandins; Suprofen; Uterus	1985
Irreversible platelet aggregation does not depend on lipoxygenase metabolites. Biochemical and biophysical research communications, 1985, Aug-30, Volume: 131, Issue:1 Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclooxygenase Inhibitors; Epinephrine; Humans; Ibuprofen; Lipoxygenase; Lipoxygenase Inhibitors; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxanes	1985
Modulation of leukotaxis by ibuprofen. A quantitative determination in vivo. Inflammation, 1985, Volume: 9, Issue:3 Topics: Animals; Anterior Chamber; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Evaluation Studies as Topic; Female; Ibuprofen; Kinetics; Leukocytes; N-Formylmethionine Leucyl-Phenylalanine; Rabbits	1985
The effects of diclofenac sodium on arachidonic acid metabolism. Seminars in arthritis and rheumatism, 1985, Volume: 15, Issue:2 Suppl 1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Leukocytes; Lipoxygenase; Naproxen; Phospholipases A; Phospholipases A2; Phospholipids; Piroxicam; Prostaglandins E; SRS-A; Thiazines; Triglycerides	1985
In vivo modulation of leukotaxis by non-steroidal anti-inflammatory drugs. Agents and actions, 1985, Volume: 17, Issue:1 Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Chemotaxis, Leukocyte; Female; Flurbiprofen; Ibuprofen; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Rabbits	1985
Effects of diclofenac sodium on arachidonic acid metabolism. Agents and actions. Supplements, 1985, Volume: 17 Topics: Arachidonic Acid; Arachidonic Acids; Diclofenac; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Leukocytes; Monocytes; Naproxen; Neutrophils; Piroxicam; SRS-A; Thiazines	1985
Evidence for lipoxygenase mediation of arachidonic acid-stimulated insulin secretion. Advances in prostaglandin, thromboxane, and leukotriene research, 1983, Volume: 12 Topics: Animals; Antioxidants; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Catechols; Cells, Cultured; Glucose; Ibuprofen; Insulin; Insulin Secretion; Islets of Langerhans; Lipoxygenase; Masoprocol; Prostaglandins	1983
Protective actions of ibuprofen in arachidonate-induced sudden death. Pharmacology, 1983, Volume: 27, Issue:3 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Pressure; Death, Sudden; Dose-Response Relationship, Drug; Ibuprofen; Male; Platelet Aggregation; Platelet Count; Rabbits; Thromboxane A2; Thromboxane B2	1983
Hyperreactivity of coronary vasculature in platelet-perfused hearts from diabetic rats. The American journal of physiology, 1983, Volume: 245, Issue:4 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cats; Coronary Circulation; Diabetes Mellitus, Experimental; Heart; Ibuprofen; Imidazoles; Male; Perfusion; Prostaglandins; Rats; Rats, Inbred Strains; Thromboxane-A Synthase	1983
Effects of indomethacin and ibuprofen on cerebral metabolism and blood flow in traumatized brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1983, Volume: 3, Issue:4 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Autoradiography; Brain; Brain Injuries; Cerebrovascular Circulation; Glucose; Ibuprofen; Indomethacin; Male; Prostaglandins; Rats; Rats, Inbred Strains	1983
Prostacyclin biosynthesis in cultured vascular endothelium is limited by deactivation of cyclooxygenase. The Journal of clinical investigation, 1983, Volume: 72, Issue:4 Topics: Antioxidants; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Endothelium; Epoprostenol; Humans; Ibuprofen; Peroxidases; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Thrombin; Umbilical Veins	1983
Activation of a 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen. The Journal of biological chemistry, 1984, Jun-10, Volume: 259, Issue:11 Topics: Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Lipoxygenase; Neutrophils; Prostaglandin-Endoperoxide Synthases; SRS-A	1984
Ibuprofen in the prevention of experimentally induced postoperative adhesions. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Abdomen; Animals; Arachidonic Acid; Arachidonic Acids; Collagen; Dose-Response Relationship, Drug; Female; Glycosaminoglycans; Ibuprofen; Inflammation; Postoperative Care; Postoperative Complications; Rabbits; Time Factors; Tissue Adhesions; Wound Healing	1984
Research on ibuprofen for sepsis and respiratory failure. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cardiac Output; Dogs; Hydrogen-Ion Concentration; Ibuprofen; Lipoxygenase; Prostaglandins; Respiratory Distress Syndrome; Shock, Septic	1984
Sedation produced by prostaglandins is not a nonspecific fatty acid effect. Psychopharmacology, 1984, Volume: 84, Issue:3 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Fatty Acids; Hypnotics and Sedatives; Ibuprofen; Indomethacin; Male; Mice; Mice, Inbred Strains; Prostaglandins; Prostaglandins F; Sleep; Time Factors	1984
The role of arachidonic acid and/or its metabolites in embryo implantation initiated by epidermal growth factor (EGF). Prostaglandins, leukotrienes, and essential fatty acids, 1995, Volume: 52, Issue:1 Topics: Animals; Arachidonic Acid; Dexamethasone; Dinoprostone; Embryo Implantation; Epidermal Growth Factor; Female; Histamine; Hypophysectomy; Ibuprofen; Indomethacin; Pregnancy; Progesterone; Rats; Uterus	1995
Divergent effects of arachidonate and other free fatty acids on glucose-stimulated insulin release from rat islets. Cellular and molecular biology (Noisy-le-Grand, France), 1994, Volume: 40, Issue:6 Topics: Animals; Arachidonic Acid; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Glucose; Ibuprofen; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Palmitic Acid; Palmitic Acids; Rats; Rats, Wistar; Structure-Activity Relationship; Time Factors	1994
Evidence that prostaglandins modulate lipogenesis in cultured lymphocytes--a comparison with its effect on macrophages and tumour cells. Biochemistry and molecular biology international, 1994, Volume: 33, Issue:3 Topics: Acetates; Animals; Arachidonic Acid; Carbon Radioisotopes; Cells, Cultured; Concanavalin A; DNA; DNA, Neoplasm; HeLa Cells; Humans; Ibuprofen; Indomethacin; KB Cells; Lipids; Lymphocyte Activation; Lymphocytes; Macrophages, Peritoneal; Neoplasms; Neoplasms, Experimental; Prostaglandins; Pyruvates; Pyruvic Acid; Rats; Thymidine; Tumor Cells, Cultured	1994
Involvement of phospholipase A2 and arachidonic acid in the depolarization-evoked accumulation of Ca2+ in hippocampal mossy fiber nerve endings. Neurochemical research, 1993, Volume: 18, Issue:12 Topics: Action Potentials; Animals; Arachidonic Acid; Calcium; Fatty Acids; Flavanones; Flavonoids; Hippocampus; Ibuprofen; Lipase; Melitten; Nerve Endings; Phospholipases A; Phospholipases A2; Potassium Chloride; Prostaglandins; Rats; Rats, Sprague-Dawley; Synaptosomes; Tetrodotoxin	1993
The mechanism of coronary collateral vasoconstriction in response to cyclooxygenase blockade. Circulation research, 1994, Volume: 74, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Collateral Circulation; Coronary Circulation; Cyclooxygenase Inhibitors; Dogs; Epoprostenol; Ibuprofen; Lipoxygenase Inhibitors; Thromboxanes; Vasoconstriction	1994
Effect of leukotrienes of renal water excretion. Prostaglandins, leukotrienes, and essential fatty acids, 1993, Volume: 48, Issue:4 Topics: Acetophenones; Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Dogs; Ibuprofen; Kidney; Leukotriene E4; Lipoxygenase Inhibitors; Osmolar Concentration; Propyl Gallate; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Tetrazoles; Urine	1993
Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1. The Journal of biological chemistry, 1996, Jan-26, Volume: 271, Issue:4 Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Arginine; Base Sequence; Binding Sites; Cyclooxygenase Inhibitors; DNA Primers; Enzyme Inhibitors; Flurbiprofen; Glutamates; Ibuprofen; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylpropionates; Prostaglandin-Endoperoxide Synthases; Protein Structure, Tertiary; Sheep; Structure-Activity Relationship; Tyrosine	1996
Low concentrations of nonsteroidal anti-inflammatory drugs affect cell functions. Life sciences, 1995, Mar-10, Volume: 56, Issue:16 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Dose-Response Relationship, Drug; Ibuprofen; Lymphocyte Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred CBA	1995
Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages. British journal of pharmacology, 1995, Volume: 116, Issue:3 Topics: Animals; Arachidonic Acid; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Ibuprofen; Indomethacin; Macrophages, Peritoneal; Male; Naproxen; Platelet Activating Factor; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Terpenes; Thapsigargin	1995
Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis. Biochemistry, 1996, Jul-16, Volume: 35, Issue:28 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Hemin; Ibuprofen; Kinetics; Molecular Structure; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostanoic Acids; Protein Binding; Protein Conformation; Sulfonamides; Thiazoles; Trypsin	1996
Effects of the cyclooxygenase inhibitor ibuprofen on retinal and choroidal blood flow during hyperoxia in newborn piglets. Biology of the neonate, 1996, Volume: 69, Issue:2 Topics: Animals; Arachidonic Acid; Blood Pressure; Carbon Monoxide; Choroid; Cyclooxygenase Inhibitors; Dinoprostone; Hydrogen-Ion Concentration; Ibuprofen; Oxygen; Prostaglandin-Endoperoxide Synthases; Prostaglandins F; Retinal Vessels; Swine; Vasoconstriction; Vitreous Body	1996
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochemical pharmacology, 1996, Oct-11, Volume: 52, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Ibuprofen; Indomethacin; Prostaglandin-Endoperoxide Synthases; Prostaglandins	1996
Effects of non-steroidal anti-inflammatory drugs on prostaglandin E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic acid in rat peritoneal macrophages stimulated with lipopolysaccharide. Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 55, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Ibuprofen; Indomethacin; Isoenzymes; Lipopolysaccharides; Macrophages, Peritoneal; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides	1996
Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism. Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera, 1995, Issue:4 Topics: Adenosine; Allopurinol; Animals; Arachidonic Acid; Aspirin; Benzofurans; Dogs; Enzyme Inhibitors; Female; Glutathione; Ibuprofen; Imidazoles; Insulin; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Kidney Tubules; Leukotriene Antagonists; Leukotrienes; Organ Preservation; Organ Preservation Solutions; Pyridines; Raffinose; Thromboxane-A Synthase	1995
Potentiation by indomethacin of receptor-mediated catecholamine secretion in rat adrenal medulla. Japanese journal of pharmacology, 1997, Volume: 73, Issue:3 Topics: Adrenal Medulla; Animals; Arachidonic Acid; Bradykinin; Calcium; Catecholamines; Chromaffin Granules; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Fluorescent Dyes; Histamine; Ibuprofen; Indoles; Indomethacin; Male; Muscarine; Muscarinic Agonists; Nicotine; Oxytocics; Potassium; Rats; Rats, Wistar	1997
Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid. The Journal of biological chemistry, 1997, May-09, Volume: 272, Issue:19 Topics: Arachidonic Acid; Binding, Competitive; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Isoenzymes; Kinetics; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Spectrometry, Fluorescence; Stereoisomerism	1997
Delayed release of prostaglandins from arachidonic acid and kinetic changes in prostaglandin H synthase activity on the induction of prostaglandin H synthase-2 after lipopolysaccharide-treatment of RAW264.7 macrophage-like cells. Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cell Line; Enzyme Induction; Escherichia coli; Ibuprofen; Indomethacin; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Prostaglandin-Endoperoxide Synthases; Prostaglandins	1997
Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochemical and biophysical research communications, 1997, Jun-18, Volume: 235, Issue:2 Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Cell Division; Cyclooxygenase Inhibitors; Eicosanoids; Enzyme Inhibitors; Flavanones; Flavonoids; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indoles; Lipoxygenase Inhibitors; Male; Masoprocol; Proadifen; Prostatic Neoplasms; Tumor Cells, Cultured	1997
Cystic fibrosis gene mutation (deltaF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells. DNA and cell biology, 1997, Volume: 16, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Calcium; Cells, Cultured; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Ibuprofen; Lipoprotein Lipase; Mutation; Phospholipases A; Phospholipases A2; Precipitin Tests; Staurosporine; Tetradecanoylphorbol Acetate	1997
Prostaglandin H synthase of mouse macrophages: inhibiting and activating action of ibuprofen. Biochemistry. Biokhimiia, 1997, Volume: 62, Issue:3 Topics: Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Enzyme Activation; Ibuprofen; Kinetics; Macrophages; Male; Mice; Microsomes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep	1997
Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat. Arzneimittel-Forschung, 1998, Volume: 48, Issue:2 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Benzimidazoles; Carrageenan; Dermatitis; Dexamethasone; Dose-Response Relationship, Drug; Edema; Histamine H1 Antagonists; Ibuprofen; Male; Rats; Rats, Sprague-Dawley	1998
Analysis of prostaglandin G/H synthase-2 inhibition using peroxidase-induced luminol luminescence. Analytical biochemistry, 1998, Nov-15, Volume: 264, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Binding, Competitive; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Ibuprofen; Indicators and Reagents; Inhibitory Concentration 50; Isoenzymes; Kinetics; Luminol; Membrane Proteins; Peroxidases; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Sensitivity and Specificity; Thiophenes; Time Factors	1998
Analyses of prostaglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. Prostaglandins & other lipid mediators, 1999, Volume: 57, Issue:2-3 Topics: Adult; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprost; Female; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Humans; Ibuprofen; Immunoenzyme Techniques; Middle Aged; Mitochondria, Liver; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases	1999
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. The Journal of experimental medicine, 1999, Aug-16, Volume: 190, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Embryo, Mammalian; Fibroblasts; Ibuprofen; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Knockout; Nitrobenzenes; Oncogene Proteins, Viral; Piroxicam; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA, Messenger; Simian virus 40; Sulfonamides; Sulindac	1999
Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:4 Topics: Alprostadil; Animals; Arachidonic Acid; Carboxylic Acids; Carcinogens, Environmental; Cell Death; Cell Division; Cells, Cultured; Dinoprostone; Epidermal Growth Factor; Fatty Acids; Fumonisins; Ibuprofen; Linoleic Acid; Liver; Mycotoxins; Rats	1999
Calcium mobilization by arachidonic acid in trypanosomatids. Molecular and biochemical parasitology, 2000, Feb-05, Volume: 105, Issue:2 Topics: Acridine Orange; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Culture Media; Ibuprofen; Lanthanum; Melitten; Membrane Potentials; Mitochondria; Organelles; Trypanosomatina	2000
Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products. The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12 Topics: Animals; Arachidonic Acid; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Hydroxyeicosatetraenoic Acids; Ibuprofen; Isoenzymes; Male; Microsomes; Models, Chemical; Mutagenesis, Site-Directed; Mutation; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Seminal Vesicles; Sheep; Stereoisomerism	2000
PKA and arachidonic acid activation of human recombinant ClC-2 chloride channels. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:1 Topics: 5,8,11,14-Eicosatetraynoic Acid; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Azoles; Cell Line; Chloride Channels; CLC-2 Chloride Channels; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Electric Conductivity; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Nonesterified; Humans; Hydrogen-Ion Concentration; Ibuprofen; Ions; Isoindoles; Nitroprusside; Organoselenium Compounds; Protein Kinase C; Recombinant Proteins	2000
Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. Cancer research, 2000, Aug-15, Volume: 60, Issue:16 Topics: 3T3 Cells; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cell Movement; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Eicosanoids; Enzyme Inhibitors; Humans; Ibuprofen; Isoenzymes; Lipoxygenase; Lipoxygenase Inhibitors; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Proteins; Mice; Neoplasm Invasiveness; Nitrobenzenes; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Sulfonamides; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Umbelliferones	2000
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs. European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sulfonamides; Thiophenes	2001
Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. American journal of hypertension, 2001, Volume: 14, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Caffeine; Calcium; Calcium Signaling; Cells, Cultured; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Ibuprofen; Lipoxygenase Inhibitors; Male; Muscle, Smooth, Vascular; Oxazines; Rats; Ryanodine	2001
Propofol potentiates phenylephrine-induced contraction via cyclooxygenase inhibition in pulmonary artery smooth muscle. Anesthesiology, 2001, Volume: 94, Issue:5 Topics: Anesthetics, Inhalation; Animals; Arachidonic Acid; Calcium; Cyclooxygenase Inhibitors; Dogs; Drug Synergism; Epoprostenol; Ibuprofen; Male; Phenylephrine; Propofol; Pulmonary Artery; Vasoconstriction	2001
Role of prostaglandins in the suppression of apoptosis in hen granulosa cells by transforming growth factor alpha. Reproduction (Cambridge, England), 2001, Volume: 122, Issue:1 Topics: Alprostadil; Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Cells, Cultured; Chickens; Chromatin; Culture Media, Serum-Free; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; DNA Fragmentation; Enzyme Inhibitors; Female; Granulosa Cells; Ibuprofen; Nitrobenzenes; Phenanthrenes; Phospholipases A; Prostaglandins; Prostaglandins E; Prostaglandins F; Sulfonamides; Transforming Growth Factor alpha	2001
Effects of phospholipase A(2) activating peptides upon GTP-binding protein-evoked adrenocorticotrophin secretion. European journal of pharmacology, 2001, Jul-27, Volume: 424, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ibuprofen; Intercellular Signaling Peptides and Proteins; Melitten; Peptides; Phospholipases A; Proteins; Tumor Cells, Cultured; Wasp Venoms	2001
The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. Journal of cancer research and clinical oncology, 2002, Volume: 128, Issue:10 Topics: Adenocarcinoma; Animals; Arachidonic Acid; Cricetinae; Cyclooxygenase Inhibitors; DNA Primers; Ethanol; Female; Genes, p53; Genes, ras; Ibuprofen; Indoles; Lipoxygenase Inhibitors; Male; Maternal-Fetal Exchange; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Pregnancy	2002
On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1. European journal of pharmacology, 2002, Oct-25, Volume: 453, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Binding, Competitive; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ibuprofen; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides	2002
Platelet activation in cystic fibrosis. Blood, 2005, Jun-15, Volume: 105, Issue:12 Topics: Adenylyl Cyclases; Adolescent; Adult; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blood Platelets; Blotting, Western; Case-Control Studies; Cell Membrane; Child; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Fatty Acids; Genotype; Humans; Ibuprofen; Inflammation; Leukocytes; Monocytes; Neutrophils; P-Selectin; Platelet Activation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboxane A2; Time Factors; Vitamin E	2005
A Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid. The Journal of laboratory and clinical medicine, 2005, Volume: 146, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Dose-Response Relationship, Drug; Humans; Ibuprofen; Platelet Activation; Platelet Aggregation; Pyrazoles; Sulfonamides; Thrombelastography	2005
Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU. Cellular microbiology, 2005, Volume: 7, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Bacterial Proteins; Bacterial Toxins; Cell Line; Dinoprostone; Eicosanoids; Endothelial Cells; Epoprostenol; Female; Group IV Phospholipases A2; Humans; Ibuprofen; Indomethacin; Inflammation; Lipoxygenase Inhibitors; Masoprocol; Mice; Mice, Inbred BALB C; Organophosphonates; Phospholipases A; Pseudomonas aeruginosa; Pseudomonas Infections	2005
The cysteinyl-leukotriene-1 receptor antagonist zafirlukast is a potent secretagogue in rat and human airways. European journal of pharmacology, 2005, Dec-19, Volume: 527, Issue:1-3 Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetates; Animals; Arachidonic Acid; Bronchi; Chromones; Cyclooxygenase Inhibitors; Cyclopropanes; Dose-Response Relationship, Drug; Humans; Ibuprofen; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Morpholines; Phenylcarbamates; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene; Sulfides; Sulfonamides; Tosyl Compounds; Trachea	2005
Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice. Life sciences, 2006, Dec-03, Volume: 80, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Ibuprofen; Indomethacin; Male; Mice; Mice, Inbred ICR; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant	2006
Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery. Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:11 Topics: Administration, Topical; Animals; Anions; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cations; Drug Carriers; Drug Delivery Systems; Drug Design; Ear; Edema; Ibuprofen; Indomethacin; Ketoprofen; Male; Mice; Permeability; Pharmaceutical Preparations; Skin Absorption; Surface-Active Agents; Swine	2007
Cytosolic phospholipase A2 and arachidonic acid metabolites modulate ventilator-induced permeability increases in isolated mouse lungs. Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:2 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ibuprofen; In Vitro Techniques; Lipoxygenase Inhibitors; Lung; Lung Diseases; Male; Masoprocol; Mice; Mice, Inbred C57BL; Microcirculation; Phospholipases A2, Cytosolic; Phosphorylation; Pulmonary Circulation; Respiration, Artificial; Signal Transduction; Vascular Resistance	2008
Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics. Prostaglandins & other lipid mediators, 2008, Volume: 85, Issue:3-4 Topics: Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Hydrogen-Ion Concentration; Ibuprofen; Kinetics; Lipid Bilayers; Liposomes; Membrane Fluidity; Micelles; Oleic Acid; Phosphatidylcholines; Phosphatidylserines; Phospholipids	2008
Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. Biochemistry, 2009, Aug-11, Volume: 48, Issue:31 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Binding, Competitive; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Endocannabinoids; Glycerides; Ibuprofen; Mefenamic Acid; Mice; Oxygen; Protein Binding	2009
Ibuprofen bioconcentration and prostaglandin E2 levels in the bluntnose minnow Pimephales notatus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2011, Volume: 153, Issue:2 Topics: Animals; Arachidonic Acid; Cyclooxygenase 1; Cyprinidae; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Inhibitory Concentration 50; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Time Factors	2011
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). American journal of physiology. Renal physiology, 2011, Volume: 301, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Diclofenac; Epithelial Sodium Channels; Female; Ibuprofen; Kidney Tubules, Collecting; Mice; Models, Animal; Ovary; Patch-Clamp Techniques; Transfection	2011
Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant. Mediators of inflammation, 2011, Volume: 2011 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Catechin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Combinations; Gene Expression Regulation, Enzymologic; Ibuprofen; In Vitro Techniques; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Male; Membrane Proteins; Osteoarthritis; Peroxidases; Phospholipase A2 Inhibitors; Phospholipases A2; Rats; Rats, Sprague-Dawley	2011
Brain thromboxane A2 via arachidonic acid cascade induces the hypothalamic-pituitary-gonadal axis activation in rats. Autonomic neuroscience : basic & clinical, 2015, Volume: 189 Topics: Animals; Arachidonic Acid; Benzofurans; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Follicle Stimulating Hormone; Growth Hormone-Releasing Hormone; Ibuprofen; Infusions, Intraventricular; Luteinizing Hormone; Male; Prostaglandin-Endoperoxide Synthases; Rats, Sprague-Dawley; Signal Transduction; Sperm Count; Sperm Motility; Testosterone; Thromboxane A2; Time Factors	2015
The effects of centrally injected arachidonic acid on respiratory system: Involvement of cyclooxygenase to thromboxane signaling pathway. Respiratory physiology & neurobiology, 2016, Volume: 225 Topics: Anesthesia; Animals; Arachidonic Acid; Benzofurans; Carbon Dioxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ibuprofen; Injections, Intraventricular; Male; Oxygen; Prostaglandin-Endoperoxide Synthases; Rats, Sprague-Dawley; Respiration; Respiratory System; Respiratory System Agents; Thromboxane A2; Tidal Volume; Time Factors	2016
Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. Journal of lipid research, 2016, Volume: 57, Issue:6 Topics: Allosteric Site; Arachidonic Acid; Arachidonic Acids; Catalytic Domain; Cyclooxygenase 2; Endocannabinoids; Ether; Glycerides; Humans; Ibuprofen; Prostaglandin H2	2016
Polyunsaturated fatty acids influence inflammatory markers in a cellular model for canine osteoarthritis. Journal of animal physiology and animal nutrition, 2018, Volume: 102, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biomarkers; Chondrocytes; Docosahexaenoic Acids; Dog Diseases; Dogs; Eicosapentaenoic Acid; Gene Expression Regulation, Enzymologic; Ibuprofen; Inflammation; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis	2018
Diet quality and NSAIDs promote changes in formation of prostaglandins by an aquatic invertebrate. Chemosphere, 2020, Volume: 257 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Diclofenac; Diet; Ibuprofen; Invertebrates; Ketoprofen; Lipid Metabolism; Naproxen; Prostaglandins	2020