ibogaine has been researched along with morphine in 38 studies
| Studies (ibogaine) | Trials (ibogaine) | Recent Studies (post-2010) (ibogaine) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 445 | 8 | 136 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | ibogaine (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (60.53) | 18.2507 |
| 2000's | 11 (28.95) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Cros, J; Francés, B; Gout, R; Zajac, JM | 1 |
| Gallagher, CA; Glick, SD; Hough, LB; Maisonneuve, IM; Rossman, KL | 1 |
| Glick, SD; Keller, RW; Maisonneuve, IM; Rossman, KL | 1 |
| Carlson, JN; Glick, SD; Maisonneuve, IM; Rao, NC; Rossman, K | 1 |
| Carlson, JN; Glick, SD; Maisonneuve, IM; Rossman, K; Steindorf, S | 1 |
| Glick, SD; Keller, RW; Maisonneuve, IM | 1 |
| Codd, EE | 1 |
| Cappendijk, SL; Dzoljic, MR; Fekkes, D | 1 |
| Glick, SD; Johnson, DW; Pearl, SM | 1 |
| Cai, J; Glick, SD; Maisonneuve, IM; Pearl, SM | 1 |
| Bandarage, UK; Glick, SD; Kuehne, ME; Maisonneuve, IM; Molinari, HH | 1 |
| Ali, SF; Dillon, K; French, ED | 1 |
| Luxton, T; Parker, LA; Siegel, S | 1 |
| Bagal, AA; Glick, SD; Hough, LB; Nalwalk, JW | 1 |
| Glick, SD; Maisonneuve, IM; Pearl, SM | 2 |
| Bhargava, HN; Cao, YJ; Zhao, GM | 1 |
| Bhargava, HN; Cao, YJ | 2 |
| Boyd, DL; Glick, SD; Hough, LB; Pearl, SM | 1 |
| Glick, SD; Maisonneuve, IS | 1 |
| Bhargava, HN; Sunder Sharma, S | 1 |
| Glick, SD; Maisonneuve, IM | 2 |
| Glick, SD; Herr, RJ; King, CH; Maisonneuve, IM; Meckler, H; Trova, MP | 1 |
| Glick, SD; Maisonneuve, IM; Szumlinski, KK | 3 |
| Parker, LA; Siegel, S | 1 |
| Burton, P; Kim, JA; McDonald, RV; Parke, LA; Siegel, S | 1 |
| Elisabetsky, E; Leal, MB; Michelin, K; Souza, DO | 1 |
| Glick, SD; Maisonneuve, IM; Panchal, V; Taraschenko, OD | 1 |
| Glick, SD; Livi, JM; Maisonneuve, IM; Ramirez, RL | 1 |
| Glick, SD; Maisonneuve, IM; Shulan, JM; Taraschenko, OD | 1 |
| Cowe, MA; Glick, SD; Lewis, SW; McCallum, SE | 1 |
| Cape, G; Devane, J; Friedhoff, L; Glue, P; Gray, A; Harland, S; Howes, J; Hung, CT; Hung, N; Lam, F; Lockhart, M; Tunnicliff, D; Weis, H | 1 |
| Ameer, B; Howes, JF; Maillet, EL; Mash, DC; Prou, D | 1 |
| Belgers, M; Donders, R; Knuijver, T; Kramers, K; Schellekens, A; van Oosteren, T; Verkes, R | 1 |
3 review(s) available for ibogaine and morphine
| Article | Year |
|---|---|
Mechanisms of antiaddictive actions of ibogaine.
Topics: Animals; Cocaine; Female; Ibogaine; Morphine; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders; Tobacco Use Disorder | 1998 |
Modulation of the effects of rewarding drugs by ibogaine.
Topics: Animals; Drug Synergism; Humans; Ibogaine; Learning; Morphine; Reward; Substance Withdrawal Syndrome; Substance-Related Disorders | 2001 |
Mechanisms of action of ibogaine: relevance to putative therapeutic effects and development of a safer iboga alkaloid congener.
Topics: Animals; Behavior, Animal; Cocaine; Humans; Ibogaine; Morphine; Motor Activity; Self Administration | 2001 |
1 trial(s) available for ibogaine and morphine
| Article | Year |
|---|---|
Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Ibogaine; Male; Methadone; Morphine; Nausea; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome | 2016 |
34 other study(ies) available for ibogaine and morphine
| Article | Year |
|---|---|
Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice.
Topics: Animals; Drug Synergism; Ibogaine; Mice; Morphine; Morphine Dependence; Naloxone; Pain Measurement; Substance Withdrawal Syndrome | 1992 |
Differential effects of ibogaine pretreatment on brain levels of morphine and (+)-amphetamine.
Topics: Animals; Brain; Dextroamphetamine; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Ibogaine; Morphine; Rats; Rats, Sprague-Dawley | 1992 |
Acute and prolonged effects of ibogaine on brain dopamine metabolism and morphine-induced locomotor activity in rats.
Topics: Animals; Brain; Dopamine; Female; Ibogaine; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor.
Topics: Acute Disease; Animals; Ibogaine; Male; Morphine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Tremor | 1992 |
Effects and aftereffects of ibogaine on morphine self-administration in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Female; Ibogaine; Morphine; Rats; Rats, Inbred Strains; Self Administration | 1991 |
Interactions between ibogaine, a potential anti-addictive agent, and morphine: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Drug Interactions; Female; Homovanillic Acid; Ibogaine; Morphine; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Self Administration; Stereotaxic Techniques | 1991 |
High affinity ibogaine binding to a mu opioid agonist site.
Topics: Animals; Binding Sites; Ibogaine; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Prosencephalon; Receptors, Opioid, mu; Tritium | 1995 |
The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine.
Topics: Animals; Arousal; Brain; Carbolines; Harmine; Ibogaine; Male; Morphine; Naloxone; Rats; Rats, Wistar; Receptors, Opioid; Substance Withdrawal Syndrome | 1994 |
Prior morphine exposure enhances ibogaine antagonism of morphine-induced locomotor stimulation.
Topics: Animals; Dose-Response Relationship, Drug; Female; Ibogaine; Locomotion; Morphine; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Ibogaine-like effects of noribogaine in rats.
Topics: Animals; Female; Ibogaine; Locomotion; Medicine, African Traditional; Morphine; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders; Time Factors | 1996 |
18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats.
Topics: Animals; Cerebellum; Cocaine; Dopamine; Female; Ibogaine; Limbic System; Morphine; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Self Administration; Tremor | 1996 |
Effects of ibogaine, and cocaine and morphine after ibogaine, on ventral tegmental dopamine neurons.
Topics: Animals; Cocaine; Dopamine; Ibogaine; Morphine; Neurons; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 1996 |
Ibogaine fails to interrupt the expression of a previously established one-trial morphine place preference.
Topics: Animals; Conditioning, Operant; Ibogaine; Male; Morphine; Narcotic Antagonists; Narcotics; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Modulation of morphine-induced antinociception by ibogaine and noribogaine.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Ibogaine; Male; Morphine; Pain Measurement; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Prior morphine exposure enhances ibogaine antagonism of morphine-induced dopamine release in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Ibogaine; Kinetics; Microdialysis; Morphine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1996 |
Effects of ibogaine and noribogaine on the antinociceptive action of mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; Male; Mice; Morphine; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Effects of ibogaine on the development of tolerance to antinociceptive action of mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; Male; Mice; Morphine; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine.
Topics: Animals; Corpus Striatum; Dopamine; Female; Ibogaine; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
Sex differences in ibogaine antagonism of morphine-induced locomotor activity and in ibogaine brain levels and metabolism.
Topics: Animals; Brain; Drug Antagonism; Female; Hallucinogens; Ibogaine; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors | 1997 |
Effects of noribogaine on the development of tolerance to antinociceptive action of morphine in mice.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Ibogaine; Injections, Intraperitoneal; Male; Mice; Morphine; Pain Measurement; Receptors, Opioid | 1997 |
Enhancement of morphine antinociception by ibogaine and noribogaine in morphine-tolerant mice.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Synergism; Drug Tolerance; Hallucinogens; Ibogaine; Injections, Intraperitoneal; Male; Mice; Morphine; Pain | 1998 |
Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Dose-Response Relationship, Drug; Drug Antagonism; Female; Homovanillic Acid; Ibogaine; Microdialysis; Morphine; Narcotics; Nucleus Accumbens; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Self Administration; Time Factors; Visual Cortex | 1999 |
Synthesis of enantiomerically pure (+)- and (-)-18-methoxycoronaridine hydrochloride and their preliminary assessment as anti-addictive agents.
Topics: Animals; Ibogaine; Morphine; Morphine Dependence; Narcotics; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration | 2000 |
The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment.
Topics: Animals; Dopamine; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Ibogaine; Microdialysis; Morphine; Morphine Dependence; Motor Activity; Narcotics; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reward; Synaptic Transmission; Time Factors | 2000 |
Development of novel medications for drug addiction. The legacy of an African shrub.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Female; Ibogaine; Morphine; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders | 2000 |
18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ibogaine; In Vitro Techniques; Morphine; Psychopharmacology; Self Administration; Substance Withdrawal Syndrome | 2000 |
Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine.
Topics: Animals; Conditioning, Psychological; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Ibogaine; Male; Morphine; Motivation; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2002 |
Ibogaine attenuation of morphine withdrawal in mice: role of glutamate N-methyl-D-aspartate receptors.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Ibogaine; Male; Mice; Morphine; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2003 |
Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridine.
Topics: Animals; Brain; Drug Administration Routes; Female; Ibogaine; Locus Coeruleus; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2005 |
18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats.
Topics: Animals; Behavior, Addictive; Conotoxins; Female; Habenula; Ibogaine; Mecamylamine; Mesencephalon; Morphine; Morphine Dependence; Narcotics; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic; Self Administration; Sucrose | 2006 |
18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Female; Homovanillic Acid; Ibogaine; Mesencephalon; Morphine; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
α3β4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Dextroamphetamine; Dopamine; Dopamine Agents; Extracellular Space; Female; Habenula; Ibogaine; Limbic System; Microdialysis; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2012 |
Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents.
Topics: Administration, Oral; Animals; Brain; Dose-Response Relationship, Drug; Ibogaine; Male; Mice; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Retrospective Studies; Rodentia; Substance Withdrawal Syndrome | 2016 |
Safety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study.
Topics: Analgesics, Opioid; Data Collection; Humans; Ibogaine; Morphine; Opioid-Related Disorders | 2022 |