Compounds > ibogaine
Page last updated: 2024-09-05

ibogaine and fluoxetine

ibogaine has been researched along with fluoxetine in 3 studies

Compound Research Comparison

Studies
(ibogaine)		Trials
(ibogaine)		Recent Studies (post-2010)
(ibogaine)		Studies
(fluoxetine)		Trials
(fluoxetine)		Recent Studies (post-2010) (fluoxetine)
445813610,1001,6633,263

Protein Interaction Comparison

ProteinTaxonomyibogaine (IC50)fluoxetine (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)5.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.119
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.303
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.358
Cytochrome P450 2D6Homo sapiens (human)0.7
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.203
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)5.2
Alpha-2B adrenergic receptorHomo sapiens (human)1.528
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.595
AcetylcholinesteraseHomo sapiens (human)0.13
Prostaglandin G/H synthase 1Homo sapiens (human)6
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.8332
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.452
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.1395
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)5.2
Sodium-dependent serotonin transporterHomo sapiens (human)0.0342
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0538
Cytochrome P450 2C19Homo sapiens (human)0.0525
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)5.2
5-hydroxytryptamine receptor 6Homo sapiens (human)1.661
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)5.2
Sodium-dependent dopamine transporter Homo sapiens (human)5.984
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.3513
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)5.2
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0094
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)5.2
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.6751
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)5.2

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Schechter, MD1
Forrest, LR; Rudnick, G; Tavoulari, S1
Basbaum, AI; Bekele, B; Billesbølle, CB; Boytsov, D; Braz, J; Craik, V; Huang, XP; Irwin, JJ; Lak, P; Manglik, A; O'Donnell, H; Pogorelov, VM; Rodriguiz, RM; Roth, BL; Roy, K; Rudnick, G; Sandtner, W; Seth, A; Shoichet, BK; Singh, I; Wetsel, WC1

Other Studies

3 other study(ies) available for ibogaine and fluoxetine

ArticleYear
Serotonergic mediation of fenfluramine discriminative stimuli in fawn-hooded rats.
    Life sciences, 1997, Volume: 60, Issue:6

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Ibogaine; Male; Methoxydimethyltryptamines; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Quipazine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Receptor Agonists

1997
Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-29, Volume: 29, Issue:30

    Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Chlorides; Cocaine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Fluoxetine; Ibogaine; Imipramine; Models, Chemical; Mutation; Protein Conformation; Protein Stability; Rats; RNA-Binding Proteins

2009
Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
    Cell, 2023, 05-11, Volume: 186, Issue:10

    Topics: Animals; Fluoxetine; Ibogaine; Mice; Molecular Conformation; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Small Molecule Libraries

2023