hypusine has been researched along with spermidine in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (34.29) | 18.7374 |
| 1990's | 9 (25.71) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 4 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Kinzy, TG; Merrick, WC; Park, MH; Wolff, EC | 1 |
| Folk, JE; Hershey, JW; Park, MH; Smit-McBride, Z; Wolff, EC | 1 |
| Autuori, F; Farrace, MG; Imparato, M; Piacentini, M; Piredda, L | 1 |
| Park, MH | 3 |
| Bernhardt, A; Gerner, EW; Mamont, PS; Siat, M | 1 |
| Gallop, PM; Paz, MA; Torrelio, BM | 2 |
| Gordon, ED; Lee, C; Lindquist, SL; Meredith, SC; Mora, R | 1 |
| Chen, KY; Dou, QP | 1 |
| Abbruzzese, A; Folk, JE; Park, MH | 1 |
| Tabor, CW; Tabor, H | 1 |
| Folk, JE; Liberato, DJ; Park, MH; Yergey, AL | 1 |
| Cooper, HL; Folk, JE; Park, MH | 1 |
| Folk, JE; Lee, YB; Park, MH | 1 |
| Folk, JE; Lee, YB; Park, MH; Wolff, EC | 1 |
| Byers, TL; Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Folk, JE; Park, MH; Wolff, EC | 1 |
| Chen, KY; Chen, ZP | 1 |
| Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO | 1 |
| Lee, CH; Park, MH | 1 |
| Beppu, T; Fukuchi-Shimogori, T; Igarashi, K; Kashiwagi, K; Nishimura, K; Ohki, Y; Saiga, K; Sakata, K; Shirahata, A | 1 |
| Chattopadhyay, MK; Tabor, CW; Tabor, H | 1 |
| Kang, KR; Kim, YS; Park, MH; Wolff, EC | 1 |
| Alhonen, L; Cerrada-Gimenez, M; Grigorenko, N; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J | 1 |
| Chattopadhyay, MK; Park, MH; Tabor, H | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Park, JH; Park, MH; Simonian, A; Vepsäläinen, J | 1 |
| Fairlamb, AH; Jones, DC; Nguyen, S; Phillips, MA; Wyllie, S | 1 |
| Corazzari, M; Ippolito, G; Oliverio, S; Piacentini, M; Piredda, L; Sestito, C | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Petit, M; Vepsäläinen, J; Weisell, J | 1 |
| Chen, M; Gai, Z; Okada, C; Yao, M; Ye, Y; Yu, J | 1 |
| Amiel, J; Banka, S; Crilly, S; Cross, LA; Cuvertino, S; Davies, SJ; Douglas, AGL; Faundes, V; Fry, AE; Gordon, CT; Granadillo, JL; Harrison, V; Jennings, MD; Kasher, PR; Legraie, S; Lehalle, D; Newkirk, P; Newman, WG; Pavitt, GD; Ranells, J; Saunders, CJ; Splitt, M; Sullivan, BR; Withers, SE | 1 |
| Beuschel, CB; Bogdanow, B; Conrad, TOF; Huang, S; Kintscher, U; Kollipara, L; Liang, Y; Liu, F; Lützkendorf, J; Madeo, F; Maglione, M; Piao, C; See, JCK; Sickmann, A; Sigrist, SJ; Toppe, D | 1 |
| Atkins, R; Cleveland, JL; Darville, LN; Elmarsafawi, AG; Epling-Burnette, PK; Fernandez, MR; Hesterberg, RS; Koomen, JM; Liu, M; Locke, FL; Mullinax, JE; Phanstiel, O; Pilon-Thomas, SA; Yang, C | 1 |
3 review(s) available for hypusine and spermidine
| Article | Year |
|---|---|
Polyamines.
Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning, Molecular; DNA; Escherichia coli; Lysine; Mutation; Neoplasms; Neurospora crassa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Physarum; Plants; Polyamines; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Putrescine; RNA; Saccharomyces cerevisiae; Spermidine; Spermidine Synthase; Spermine; Spermine Synthase | 1984 |
Is hypusine essential for eukaryotic cell proliferation?
Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins; Spermidine | 1993 |
Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biological Evolution; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Elongation Factors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Alignment; Spermidine; Substrate Specificity | 2007 |
32 other study(ies) available for hypusine and spermidine
| Article | Year |
|---|---|
Two isoforms of eIF-5A in chick embryo. Isolation, activity, and comparison of sequences of the hypusine-containing proteins.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chick Embryo; Chickens; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Genetic Variation; Humans; Lysine; Male; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Putrescine; Rabbits; RNA-Binding Proteins; Sequence Homology, Nucleic Acid; Spermidine; Tritium | 1992 |
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
Topics: Animals; Cadaverine; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; Eflornithine; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Periodic Acid; Puromycin; RNA-Binding Proteins; Spermidine; Substrate Specificity | 1991 |
Polyamine-dependent post-translational modification of proteins in differentiating mouse epidermal cells.
Topics: Animals; Cell Differentiation; Epidermal Cells; Keratinocytes; Lysine; Mice; Mice, Inbred BALB C; Polyamines; Protein Processing, Post-Translational; Spermidine | 1990 |
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
Topics: Animals; Cell Line; Cricetinae; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; Putrescine; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship | 1989 |
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Rats; RNA-Binding Proteins; Spermidine; Spermine | 1986 |
The formation and stability of the hypusine containing protein in Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Lysine; Molecular Weight; Ovary; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Spermine | 1987 |
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Eflornithine; Female; Fibroblasts; Gene Expression Regulation; Lysine; Ovary; Protein Biosynthesis; Protein Processing, Post-Translational; Spermidine | 1987 |
Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.
Topics: Amino Acids; Animals; Cells; Drosophila melanogaster; Escherichia coli; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Peptide Mapping; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine | 1987 |
NAD+ stimulated the spermidine-dependent hypusine formation on the 18 kDa protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.
Topics: Animals; Cell Line; Cytosol; Lysine; Mice; Molecular Weight; NAD; Nerve Tissue Proteins; Neuroblastoma; Putrescine; Spermidine; Tritium | 1988 |
The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Isoelectric Point; Lysine; Ovary; Peptide Initiation Factors; Peptide Mapping; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 1988 |
Post-translational formation of hypusine: biogenesis of translation initiation factor eIF-4D.
Topics: Animals; Eukaryotic Initiation Factor-4F; Gene Expression Regulation; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Putrescine; Spermidine | 1988 |
Cellular proliferation and hypusine synthesis.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Culture Media; DNA; Female; Fibroblasts; Humans; Kinetics; Lysine; Ovary; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine | 1984 |
The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.
Topics: Animals; Butylamines; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Mass Spectrometry; Putrescine; Spermidine | 1984 |
Hypusine formation: a unique posttranslational modification in translation initiation factor eIF-4D.
Topics: Animals; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Humans; Lymphocytes; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; Radioisotope Dilution Technique; Reticulocytes; RNA-Binding Proteins; Spermidine; Tritium | 1984 |
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
Topics: Animals; Binding, Competitive; Cell Division; CHO Cells; Cricetinae; Cricetulus; Diamines; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Rats; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship; Testis | 1995 |
Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.
Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Diamines; Dose-Response Relationship, Drug; Guanine; Indicators and Reagents; Kinetics; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine; Structure-Activity Relationship | 1994 |
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Leukemia L1210; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine; Spermine; Substrate Specificity; Tumor Cells, Cultured | 1994 |
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Lysine; Mice; Oncogene Protein p21(ras); Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1997 |
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured | 1998 |
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
Topics: Binding Sites; Eukaryotic Initiation Factor-5; Humans; Hydrogen-Ion Concentration; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Spermidine; Substrate Specificity; Time Factors | 2000 |
Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin.
Topics: Animals; Antibiotics, Antineoplastic; Eukaryotic Translation Initiation Factor 5A; Female; Guanidines; Lysine; Mice; Models, Chemical; Peptide Initiation Factors; Putrescine; RNA Caps; RNA-Binding Proteins; RNA, Messenger; Spermidine; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.
Topics: Base Sequence; DNA, Fungal; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Kinetics; Lysine; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamine Oxidase; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spermidine; Spermine; Substrate Specificity | 2003 |
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Models, Biological; Pancreatitis; Peptide Initiation Factors; Polyamines; Rats; Recombinant Proteins; RNA-Binding Proteins; Spermidine; Stereoisomerism | 2007 |
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine.
Topics: Eukaryotic Translation Initiation Factor 5A; Intracellular Space; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine; Tritium | 2008 |
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Methylation; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 2012 |
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
Topics: Animals; Cattle; Escherichia coli; Gene Knockdown Techniques; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Protozoan Proteins; Recombinant Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, Bovine | 2013 |
The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
Topics: Autophagy; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Fibrosarcoma; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 2014 |
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
Topics: Biological Transport; Cell Line, Tumor; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Male; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine; Stereoisomerism; Substrate Specificity | 2015 |
Flexible NAD
Topics: Binding Sites; Crystallography, X-Ray; Eukaryota; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spermidine | 2020 |
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
Topics: Adolescent; Amino Acid Sequence; Animals; Child; Developmental Disabilities; Embryo, Nonmammalian; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Developmental; Humans; Lysine; Male; Microcephaly; Micrognathism; Peptide Initiation Factors; Peptides; Protein Biosynthesis; Protein Conformation; Protein Isoforms; Ribosomes; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spermidine; Zebrafish; Zebrafish Proteins | 2021 |
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
Topics: Administration, Oral; Aging, Premature; Animals; Brain; Cell Respiration; Drosophila melanogaster; Drosophila Proteins; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Locomotion; Lysine; Memory; Mitochondria; Mitochondrial Proteins; Models, Animal; Neurons; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 2021 |
Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells.
Topics: CD8-Positive T-Lymphocytes; Glutamine; Humans; Memory T Cells; Polyamines; Spermidine | 2023 |