Page last updated: 2024-08-24

hypusine and spermidine

hypusine has been researched along with spermidine in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199012 (34.29)18.7374
1990's9 (25.71)18.2507
2000's6 (17.14)29.6817
2010's4 (11.43)24.3611
2020's4 (11.43)2.80

Authors

AuthorsStudies
Kinzy, TG; Merrick, WC; Park, MH; Wolff, EC1
Folk, JE; Hershey, JW; Park, MH; Smit-McBride, Z; Wolff, EC1
Autuori, F; Farrace, MG; Imparato, M; Piacentini, M; Piredda, L1
Park, MH3
Bernhardt, A; Gerner, EW; Mamont, PS; Siat, M1
Gallop, PM; Paz, MA; Torrelio, BM2
Gordon, ED; Lee, C; Lindquist, SL; Meredith, SC; Mora, R1
Chen, KY; Dou, QP1
Abbruzzese, A; Folk, JE; Park, MH1
Tabor, CW; Tabor, H1
Folk, JE; Liberato, DJ; Park, MH; Yergey, AL1
Cooper, HL; Folk, JE; Park, MH1
Folk, JE; Lee, YB; Park, MH1
Folk, JE; Lee, YB; Park, MH; Wolff, EC1
Byers, TL; Coward, JK; Lakanen, JR; Pegg, AE1
Folk, JE; Park, MH; Wolff, EC1
Chen, KY; Chen, ZP1
Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO1
Lee, CH; Park, MH1
Beppu, T; Fukuchi-Shimogori, T; Igarashi, K; Kashiwagi, K; Nishimura, K; Ohki, Y; Saiga, K; Sakata, K; Shirahata, A1
Chattopadhyay, MK; Tabor, CW; Tabor, H1
Kang, KR; Kim, YS; Park, MH; Wolff, EC1
Alhonen, L; Cerrada-Gimenez, M; Grigorenko, N; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J1
Chattopadhyay, MK; Park, MH; Tabor, H1
Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Park, JH; Park, MH; Simonian, A; Vepsäläinen, J1
Fairlamb, AH; Jones, DC; Nguyen, S; Phillips, MA; Wyllie, S1
Corazzari, M; Ippolito, G; Oliverio, S; Piacentini, M; Piredda, L; Sestito, C1
Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Petit, M; Vepsäläinen, J; Weisell, J1
Chen, M; Gai, Z; Okada, C; Yao, M; Ye, Y; Yu, J1
Amiel, J; Banka, S; Crilly, S; Cross, LA; Cuvertino, S; Davies, SJ; Douglas, AGL; Faundes, V; Fry, AE; Gordon, CT; Granadillo, JL; Harrison, V; Jennings, MD; Kasher, PR; Legraie, S; Lehalle, D; Newkirk, P; Newman, WG; Pavitt, GD; Ranells, J; Saunders, CJ; Splitt, M; Sullivan, BR; Withers, SE1
Beuschel, CB; Bogdanow, B; Conrad, TOF; Huang, S; Kintscher, U; Kollipara, L; Liang, Y; Liu, F; Lützkendorf, J; Madeo, F; Maglione, M; Piao, C; See, JCK; Sickmann, A; Sigrist, SJ; Toppe, D1
Atkins, R; Cleveland, JL; Darville, LN; Elmarsafawi, AG; Epling-Burnette, PK; Fernandez, MR; Hesterberg, RS; Koomen, JM; Liu, M; Locke, FL; Mullinax, JE; Phanstiel, O; Pilon-Thomas, SA; Yang, C1

Reviews

3 review(s) available for hypusine and spermidine

ArticleYear
Polyamines.
    Annual review of biochemistry, 1984, Volume: 53

    Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning, Molecular; DNA; Escherichia coli; Lysine; Mutation; Neoplasms; Neurospora crassa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Physarum; Plants; Polyamines; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Putrescine; RNA; Saccharomyces cerevisiae; Spermidine; Spermidine Synthase; Spermine; Spermine Synthase

1984
Is hypusine essential for eukaryotic cell proliferation?
    Trends in biochemical sciences, 1993, Volume: 18, Issue:12

    Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins; Spermidine

1993
Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Amino Acid Sequence; Animals; Binding Sites; Biological Evolution; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Elongation Factors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Alignment; Spermidine; Substrate Specificity

2007

Other Studies

32 other study(ies) available for hypusine and spermidine

ArticleYear
Two isoforms of eIF-5A in chick embryo. Isolation, activity, and comparison of sequences of the hypusine-containing proteins.
    The Journal of biological chemistry, 1992, Mar-25, Volume: 267, Issue:9

    Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chick Embryo; Chickens; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Genetic Variation; Humans; Lysine; Male; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Putrescine; Rabbits; RNA-Binding Proteins; Sequence Homology, Nucleic Acid; Spermidine; Tritium

1992
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
    The Journal of biological chemistry, 1991, May-05, Volume: 266, Issue:13

    Topics: Animals; Cadaverine; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; Eflornithine; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Periodic Acid; Puromycin; RNA-Binding Proteins; Spermidine; Substrate Specificity

1991
Polyamine-dependent post-translational modification of proteins in differentiating mouse epidermal cells.
    The Journal of investigative dermatology, 1990, Volume: 94, Issue:5

    Topics: Animals; Cell Differentiation; Epidermal Cells; Keratinocytes; Lysine; Mice; Mice, Inbred BALB C; Polyamines; Protein Processing, Post-Translational; Spermidine

1990
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Animals; Cell Line; Cricetinae; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; Putrescine; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship

1989
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
    The Biochemical journal, 1986, Oct-15, Volume: 239, Issue:2

    Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Rats; RNA-Binding Proteins; Spermidine; Spermine

1986
The formation and stability of the hypusine containing protein in Chinese hamster ovary cells.
    Biochemical and biophysical research communications, 1987, Jun-30, Volume: 145, Issue:3

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Lysine; Molecular Weight; Ovary; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Spermine

1987
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.
    The Journal of biological chemistry, 1987, Sep-15, Volume: 262, Issue:26

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Eflornithine; Female; Fibroblasts; Gene Expression Regulation; Lysine; Ovary; Protein Biosynthesis; Protein Processing, Post-Translational; Spermidine

1987
Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.
    The Journal of biological chemistry, 1987, Dec-05, Volume: 262, Issue:34

    Topics: Amino Acids; Animals; Cells; Drosophila melanogaster; Escherichia coli; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Peptide Mapping; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine

1987
NAD+ stimulated the spermidine-dependent hypusine formation on the 18 kDa protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.
    FEBS letters, 1988, Mar-14, Volume: 229, Issue:2

    Topics: Animals; Cell Line; Cytosol; Lysine; Mice; Molecular Weight; NAD; Nerve Tissue Proteins; Neuroblastoma; Putrescine; Spermidine; Tritium

1988
The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells.
    The Journal of biological chemistry, 1988, Jun-05, Volume: 263, Issue:16

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Isoelectric Point; Lysine; Ovary; Peptide Initiation Factors; Peptide Mapping; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine

1988
Post-translational formation of hypusine: biogenesis of translation initiation factor eIF-4D.
    Advances in experimental medicine and biology, 1988, Volume: 231

    Topics: Animals; Eukaryotic Initiation Factor-4F; Gene Expression Regulation; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Putrescine; Spermidine

1988
Cellular proliferation and hypusine synthesis.
    Experimental cell research, 1984, Volume: 154, Issue:2

    Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Culture Media; DNA; Female; Fibroblasts; Humans; Kinetics; Lysine; Ovary; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine

1984
The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.
    The Journal of biological chemistry, 1984, Oct-10, Volume: 259, Issue:19

    Topics: Animals; Butylamines; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Mass Spectrometry; Putrescine; Spermidine

1984
Hypusine formation: a unique posttranslational modification in translation initiation factor eIF-4D.
    Methods in enzymology, 1984, Volume: 106

    Topics: Animals; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Humans; Lymphocytes; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; Radioisotope Dilution Technique; Reticulocytes; RNA-Binding Proteins; Spermidine; Tritium

1984
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
    Journal of medicinal chemistry, 1995, Aug-04, Volume: 38, Issue:16

    Topics: Animals; Binding, Competitive; Cell Division; CHO Cells; Cricetinae; Cricetulus; Diamines; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Rats; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship; Testis

1995
Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.
    The Journal of biological chemistry, 1994, Nov-11, Volume: 269, Issue:45

    Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Diamines; Dose-Response Relationship, Drug; Guanine; Indicators and Reagents; Kinetics; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine; Structure-Activity Relationship

1994
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
    The Biochemical journal, 1994, Oct-15, Volume: 303 ( Pt 2)

    Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Leukemia L1210; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine; Spermine; Substrate Specificity; Tumor Cells, Cultured

1994
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
    Cancer letters, 1997, May-19, Volume: 115, Issue:2

    Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Lysine; Mice; Oncogene Protein p21(ras); Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine

1997
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
    Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20

    Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured

1998
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
    The Biochemical journal, 2000, Dec-15, Volume: 352 Pt 3

    Topics: Binding Sites; Eukaryotic Initiation Factor-5; Humans; Hydrogen-Ion Concentration; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Spermidine; Substrate Specificity; Time Factors

2000
Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin.
    The Biochemical journal, 2002, May-01, Volume: 363, Issue:Pt 3

    Topics: Animals; Antibiotics, Antineoplastic; Eukaryotic Translation Initiation Factor 5A; Female; Guanidines; Lysine; Mice; Models, Chemical; Peptide Initiation Factors; Putrescine; RNA Caps; RNA-Binding Proteins; RNA, Messenger; Spermidine; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Base Sequence; DNA, Fungal; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Kinetics; Lysine; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamine Oxidase; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spermidine; Spermine; Substrate Specificity

2003
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
    The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48

    Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Models, Biological; Pancreatitis; Peptide Initiation Factors; Polyamines; Rats; Recombinant Proteins; RNA-Binding Proteins; Spermidine; Stereoisomerism

2007
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, May-06, Volume: 105, Issue:18

    Topics: Eukaryotic Translation Initiation Factor 5A; Intracellular Space; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine; Tritium

2008
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
    Amino acids, 2012, Volume: 42, Issue:2-3

    Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Methylation; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine

2012
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
    The Journal of biological chemistry, 2013, May-24, Volume: 288, Issue:21

    Topics: Animals; Cattle; Escherichia coli; Gene Knockdown Techniques; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Protozoan Proteins; Recombinant Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, Bovine

2013
The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
    Amino acids, 2014, Volume: 46, Issue:12

    Topics: Autophagy; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Fibrosarcoma; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine

2014
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
    ACS chemical biology, 2015, Jun-19, Volume: 10, Issue:6

    Topics: Biological Transport; Cell Line, Tumor; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Male; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine; Stereoisomerism; Substrate Specificity

2015
Flexible NAD
    International journal of molecular sciences, 2020, Jul-31, Volume: 21, Issue:15

    Topics: Binding Sites; Crystallography, X-Ray; Eukaryota; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spermidine

2020
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
    Nature communications, 2021, 02-05, Volume: 12, Issue:1

    Topics: Adolescent; Amino Acid Sequence; Animals; Child; Developmental Disabilities; Embryo, Nonmammalian; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Developmental; Humans; Lysine; Male; Microcephaly; Micrognathism; Peptide Initiation Factors; Peptides; Protein Biosynthesis; Protein Conformation; Protein Isoforms; Ribosomes; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spermidine; Zebrafish; Zebrafish Proteins

2021
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
    Cell reports, 2021, 04-13, Volume: 35, Issue:2

    Topics: Administration, Oral; Aging, Premature; Animals; Brain; Cell Respiration; Drosophila melanogaster; Drosophila Proteins; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Locomotion; Lysine; Memory; Mitochondria; Mitochondrial Proteins; Models, Animal; Neurons; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine

2021
Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells.
    JCI insight, 2023, 09-22, Volume: 8, Issue:18

    Topics: CD8-Positive T-Lymphocytes; Glutamine; Humans; Memory T Cells; Polyamines; Spermidine

2023