Page last updated: 2024-08-24

hypusine and lysine

hypusine has been researched along with lysine in 185 studies

Research

Studies (185)

TimeframeStudies, this research(%)All Research%
pre-199031 (16.76)18.7374
1990's48 (25.95)18.2507
2000's37 (20.00)29.6817
2010's48 (25.95)24.3611
2020's21 (11.35)2.80

Authors

AuthorsStudies
Byers, TL; Ganem, B; Pegg, AE1
Bartig, D; Klink, F1
Bartig, D; Frank, J; Klink, F; Lemkemeier, K; Lottspeich, F1
Chamot, D; Kuhlemeier, C1
Kinzy, TG; Merrick, WC; Park, MH; Wolff, EC1
Folk, JE; Hershey, JW; Park, MH; Smit-McBride, Z; Wolff, EC1
Kakimoto, Y; Kotani, K; Sano, A; Ueno, S1
Chung, SI; Folk, JE; Lewis, MS; Park, MH1
Hershey, JW; Kang, HA; Schnier, J; Schwelberger, HG; Smit-McBride, Z1
Abbruzzese, A; Beninati, S; Folk, JE1
Autuori, F; Farrace, MG; Imparato, M; Piacentini, M; Piredda, L1
Hershey, JW; Schnier, J; Smit-McBride, Z1
Chen, KY; Dou, QP3
Chen, KY; Davis, RH; Seyfzadeh, M; Yang, YC1
Dever, TE; Hershey, JW; Merrick, WC; Smit-McBride, Z1
Hershey, JW; Kaufman, RJ; Schnier, J; Smit-McBride, Z1
Park, MH4
Centea-Intemann, M; Lottspeich, F; Noegel, AA; Sandholzer, U1
Chang, ZF; Chen, KY1
Abbruzzese, A; Folk, JE; Park, MH2
Duncan, RF; Hershey, JW1
Folk, JE; Park, MH1
Liu, TY; Neece, SH; Park, MH; Swiggard, WJ1
Bernhardt, A; Gerner, EW; Mamont, PS; Siat, M1
Chused, TM; Coligan, J; Cooper, HL; Lal, RB1
Gallop, PM; Paz, MA; Torrelio, BM3
Gerner, EW; Murphey, RJ1
Gordon, ED; Lee, C; Lindquist, SL; Meredith, SC; Mora, R1
Gordon, ED; Lindquist, SL; Meredith, SC; Mora, R1
Abbruzzese, A; Folk, JE; Park, MH; Wolff, EC1
Gerner, EW; Murphey, RJ; Tome, ME1
Tabor, CW; Tabor, H1
Braverman, R; Cooper, HL; Folk, JE; Park, MH; Safer, B1
Chung, SI; Cooper, HL; Folk, JE; Park, MH1
Kakimoto, Y; Miyake, M; Sano, A1
Folk, JE; Liberato, DJ; Park, MH; Yergey, AL1
Cooper, HL; Folk, JE; Park, MH2
Auer, M; Csonga, R; Eckerskorn, C; Eder, J; Joäo, HC; Klier, H; Lottspeich, F1
Auer, M; Csonga, R; Eder, J; João, HC; Klier, H; Koettnitz, K1
Klier, H; Lottspeich, F; Wöhl, T1
Chung, SI; Folk, JE; Kang, KR; Park, MH; Wolff, EC1
Folk, JE; Lee, YB; Park, MH1
Hanauske, AR; Hanauske-Abel, HM; McCaffrey, T; Slowinska, B; Staiano-Coico, L; Szabo, P; Wilson, RC; Zagulska, S1
Abbruzzese, A; Beninati, S; Jakus, J; Nicolini, L; Passeggio, A1
Joe, YA; Park, MH; Rinaudo, MS1
Folk, JE; Lee, YB; Park, MH; Wolff, EC1
Hauber, J; Hirt, H; Klier, H; Klink, F; Lottspeich, F; Magdolen, V; Wöhl, T1
Baumruker, T; Bevec, D; Hauber, J; Holter, W; Klier, H; Lottspeich, F; Tschachler, E; Valent, P1
Byers, TL; Coward, JK; Lakanen, JR; Pegg, AE1
Folk, JE; Park, MH; Wolff, EC2
Folk, JE; Hanauske, AR; Hanauske-Abel, HM; Lalande, M; Park, MH; Popowicz, AM1
Eckerskorn, C; Klier, H; Lottspeich, F; Magdolen, V; Wöhl, T1
Ammer, H; Klier, H; Lottspeich, F; Magdolen, V; Wöhl, T1
Hershey, JW; Kang, HA; Schwelberger, HG2
Auer, M; Csonga, R; Eckerskorn, C; Eder, J; Ettmayer, P; Klier, H1
Abid, MR; Miyazaki, M; Sasaki, K1
Beppu, T; Samejima, K; Shirahata, A1
Gerner, EW; Tome, ME1
Chen, KY; Chen, ZP2
Abbruzzese, A; Beninati, S; Bianco, AR; Caraglia, M; Improta, S; Leardi, A; Nicolini, L; Passeggio, A; Pinto, A; Tagliaferri, P1
Fiser, SM; Gerner, EW; Payne, CM; Tome, ME1
Andrus, L; Grady, RW; Hanauske, AR; Hanauske-Abel, HM; Huima-Byron, T; Slowinska, B; Szabo, P; Zagulska, S1
Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO2
Abbruzzese, A; Beninati, S; Caraglia, M; Gentile, V; Lentini, A; Tagliaferri, P1
Park, MH; Wolff, EC2
Kwa, MS; Thomas, AA; van Marwijk, M; van Oers, MM; Vlak, JM1
Jansson, BP; Johansson, HE; Malandrin, L1
Abbruzzese, A; Budillon, A; Caraglia, M; Tagliaferri, P1
Bevec, D; Hauber, J; Krätzer, F; Kruse, M; Kuhnt, C; Rosorius, O; Schuler, G; Steinkasserer, A1
Bischoff, FR; Görlich, D; Hartmann, E; Kostka, S; Kraft, R; Kutay, U; Lipowsky, G; Schwarzmaier, P1
Chen, KY; Xu, A1
Lee, CH; Park, MH1
Abbruzzese, A; Beninati, S; Budillon, A; Caraglia, M; D'Alessandro, AM; del Prete, S; Giuberti, G; Lentini, A; Marra, M1
Albrecht, BK; DeMong, DE; Jain, RP; Williams, RM1
Beppu, T; Fukuchi-Shimogori, T; Igarashi, K; Kashiwagi, K; Nishimura, K; Ohki, Y; Saiga, K; Sakata, K; Shirahata, A1
Jao, DL; Yu Chen, K1
Joe, YA; Kim, HK; Lee, Y; Park, HE; Park, MH1
Kikukawa, S; Kimura, M; Ohsawa, A; Tanaka, I; Yao, M1
Abbruzzese, A; Baldi, A; Caraglia, M; D'Alessandro, AM; Giuberti, G; Marra, M; Tagliaferri, P; Tassone, P; Venuta, S1
He, K; Hu, MR; Jin, BF; Lan, Y; Shen, BF; Wang, HX; Wang, J; Wei, KH; Yang, SC; Zhang, XM; Zhou, T1
He, K; Hu, MR; Jin, BF; Shen, BF; Yu, M; Zhang, XM1
Chattopadhyay, MK; Tabor, CW; Tabor, H1
Igarashi, K; Kashiwagi, K; Murozumi, K; Nishimura, K; Park, MH; Shirahata, A1
Bevec, D; Choidas, A; Harrer, T; Hauber, I; Hauber, J; Heukeshoven, J; Horn, F; Krätzer, F1
Chen, KY; Jao, DL1
Clement, PM; Johansson, HE; Park, MH; Wolff, EC1
Gregio, AP; Komili, S; Lustri, WR; Maragno, AL; Mestriner, CA; Pandolfi, JR; Valentini, SR; Zanelli, CF1
Balabanov, S; Bokemeyer, C; Brassat, U; Brümmendorf, TH; Copland, M; Gontarewicz, A; Hartmann, U; Hauber, I; Hauber, J; Holyoake, TL; Kammer, W; Kanz, L; Nordheim, A; Priemer, M; Schwarz, G; Wilhelm, T; Ziegler, P1
Goebel, T; Hoerauf, A; Holzgrabe, U; Kaiser, A; Saeftel, M; Ulmer, D1
Hester, L; Higginson, DS; Huang, Y; Park, MH; Snyder, SH1
Klug, G; Wagner, S1
Kang, KR; Kim, YS; Park, MH; Wolff, EC1
Abbruzzese, A; Agostinelli, E; Budillon, A; Caraglia, M; Giuberti, G; Lombardi, A; Marra, M; Meo, G; Tempera, G1
Alhonen, L; Cerrada-Gimenez, M; Grigorenko, N; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J1
Cano, VS; Henderson, CA; Hershey, JW; Jeon, GA; Johansson, HE; Park, JH; Park, MH; Valentini, SR1
Chattopadhyay, MK; Park, MH; Tabor, H1
Baptista, IL; Cambiaghi, TD; Costa-Neto, CM; Curi, R; Hirabara, SM; Lambertucci, RH; Luchessi, AD; Moriscot, AS; Silveira, LR1
Blatch, GL; Dorrington, RA; Gentz, PM1
Do, JW; Hong, GE; Kim, KK; Kim, WJ; Kim, YO; Kong, HJ; Lee, CH; Lee, JH; Lee, SJ; Nam, BH1
Kaevel, J; Lee, SB; Park, JH; Park, MH; Sramkova, M; Weigert, R1
Dever, TE; Eyler, DE; Green, R; Saini, P1
Atemnkeng, V; Blavid, R; Frommholz, D; Kaiser, AE; Kusch, P; Marciniak, J; Marcus, K; Scheer, H; Tu, JM; Zhao, KH1
D'Alliessi Gandolfi, D; Hanauske-Abel, HM; Hoque, M; Mathews, MB; Palumbo, P; Park, MH; Pe'ery, T; Saxena, D1
Nishimura, K; Park, MH; Valentini, SR; Zanelli, CF1
Anderson, P; Ivanov, P; Li, CH; Ohn, T; Tisdale, S1
Chakrabarti, SK; Dinarello, CA; Dondero, RS; Lewis, EC; Maier, B; Mirmira, RG; Nadler, JL; Nunemaker, CS; Ogihara, T; Robbins, RD; Stull, ND; Taylor, CA; Tersey, SA; Thompson, JE; Trace, AP1
Maier, B; Mirmira, RG; Tersey, SA1
Edvokimova, E; Fang, FC; Ibba, M; Kumar, R; Navarre, WW; Prost, LR; Roy, H; Savchenko, A; Singer, A; Xie, JL; Zou, SB1
Deck, JA; Folk, JE; Fraser, CS; Lee, SB; Park, JH; Park, MH; Pegg, AE; Sokabe, M1
Dias, CA; Fraser, CS; Lee, SB; Park, JH; Park, MH; Sokabe, M; Valentini, SR1
Agostinelli, E; Kaiser, A; Khomutov, AR; Simonian, A1
Altmann, M; Bütikofer, P; Greganova, E1
Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Park, JH; Park, MH; Simonian, A; Vepsäläinen, J1
Abbruzzese, A; Caraglia, M; Marra, M; Park, MH; Wolff, EC1
Balabanov, S; Bokemeyer, C; Dyshlovoy, SA; Fedorov, SN; Gesell Salazar, M; Hauber, J; Honecker, F; Jacobsen, C; Krepstakies, M; Naeth, I; Preukschas, M; Priyadarshini, P; Scharf, C; Shubina, LK; Sievert, H; Stonik, VA; Venz, S; Walther, R1
Chawla, B; Kumar, RR; Madhubala, R; Park, MH; Srinivasan, N; Subramanian, G; Tyagi, N1
Appelmann, I; Krasnitz, A; Lindqvist, L; Lowe, SW; Miething, C; Pappin, D; Pelletier, J; Reyes, J; Ruse, C; Scuoppo, C; Teruya-Feldstein, J; Yoon, S1
Ishfaq, M; Ito, A; Maeda, S; Maeta, K; Natsume, T; Yoshida, M1
Balabanov, S; Bokemeyer, C; Braig, M; Brümmendorf, TH; Dhople, VM; Duncan, KE; Hauber, J; Nagel, CH; Pällmann, N; Platas-Barradas, O; Pörtner, R; Preukschas, M; Schaletzky, M; Sievert, H; Venz, S; Walther, R1
Balabanov, S; Bokemeyer, C; Braig, M; Hagel, C; Hauber, J; Lamszus, K; Pällmann, N; Preukschas, M; Schulte, A; Sievert, H; Weber, K1
Fairlamb, AH; Jones, DC; Nguyen, S; Phillips, MA; Wyllie, S1
Galvão, FC; Rossi, D; Silveira, Wda S; Valentini, SR; Zanelli, CF1
de Almeida, OP; Galvão, FC; Medeiros, AI; Rossetto, Dde B; Rossi, D; Toledo, TR; Valentini, SR; Watanabe, TF; Zanelli, CF1
Balabanov, S; Boettcher, S; Bokemeyer, C; Braig, M; Brümmendorf, TH; Duncan, KE; Hauber, J; Hengartner, MO; Hermans-Borgmeyer, I; Janiesch, PC; Manz, MG; Miller, KK; Pällmann, N; Preukschas, M; Schweizer, M; Sendoel, A; Sievert, H; Streichert, T; Venz, S; Walther, R1
Gowri, VS; Madhubala, R; Mandal, S; Mittal, N; Morada, M; Park, MH; Quirch, A; Tripathi, P; Yarlett, N1
Corazzari, M; Ippolito, G; Oliverio, S; Piacentini, M; Piredda, L; Sestito, C1
Bouvet, M; Fujimura, K; Kaushal, S; Kelber, JA; Klemke, RL; Lowy, AM; Metildi, C; Strnadel, J; Wright, T1
Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Petit, M; Vepsäläinen, J; Weisell, J1
Deshayes, K; Fang, G; Pham, V; Song, A; Tan, D; Tom, J; Yu, T; Yu, Z; Zhang, D1
Böttger, LH; Han, Z; Hauber, J; Hilgenfeld, R; Klinke, S; Sakai, N; Trautwein, AX1
Hershey, JW; Mathews, MB1
Balabanov, S; Bokemeyer, C; Braig, M; Hagel, C; Haralambieva, E; Hauber, J; Hermans-Borgmeyer, I; Nagel, CH; Neumann, M; Pällmann, N; Preukschas, M; Schweizer, M; Sievert, H; Wild, P1
Gulappa, T; Menon, B; Menon, KM1
Carter, PJ; Deshayes, K; Dixit, VM; He, M; Song, A; Zhai, Q1
Fujiwara, N; Imoto, S; Inazawa, J; Kawano, T; Kozaki, KI; Miyano, S; Morishita, M; Muramatsu, T; Tsuda, H; Yamaguchi, R1
Choi, UY; Choi, WY; Kang, JS; Kim, CH; Kim, YJ; Kim-Ha, J; Lee, WB; Zhang, Q1
Chemnitz, J; Hadeler, B; Hauber, J; Kröger, C; Martinez-Rocha, AL; Schäfer, W; Willingmann, P; Woriedh, M1
Barbosa, NM; Boldrin, PE; Fraser, CS; Galvão, FC; Hershey, JW; Rossi, D; Valentini, SR; Zanelli, CF1
Aksu, M; Görlich, D; Trakhanov, S1
Cleveland, JL; Nakanishi, S1
Almeida, IC; de Proença, AR; Lourenço, RF; Luchessi, AD; Meneguello, L; Pereira, KD; Tamborlin, L1
Connor, JH; Olsen, ME1
Dever, TE; Gutierrez, E; Katoh, T; Kim, JR; Shin, BS; Suga, H1
Fujimura, K; Klemke, RL; Wang, H; Watson, F1
Amici, A; Bassani, F; Benelli, D; Bläsi, U; Cacciamani, T; La Teana, A; Londei, P; Märtens, B; Romagnoli, A1
Turpaev, KT1
de Proença, ARG; Luchessi, AD; Meneguello, L; Pereira, KD; Tamborlin, L1
Au, PB; Chung, WK; Deng, L; Devinsky, O; Ganapathi, M; Hanner, A; Karlowicz, D; LeDuc, CA; Lee, J; Mastracci, TL; McDonald, M; Mirmira, RG; Okur, V; Padgett, LR; Park, MH; Person, R; Shen, Y; Tagoe, J; Wang, J; Willaert, R; Wolf, B; Yamada, K1
Boca, SM; Gill, K; Hathout, Y; Hoffman, EP; Li, Z; Nagaraju, K; Ressom, HW; Thangarajh, M; Varghese, RS; Zhang, A1
Alonso, LC; Anderson-Baucum, E; Bernal-Mizrachi, E; Garcia-Ocaña, A; Levasseur, EM; Liu, Y; Maier, B; Mastracci, TL; Mirmira, RG; Mosley, AL; Orr, KS; Piñeros, AR; Scott, D; Syed, F; Tersey, SA; Wu, W; Yamada, K1
Bekebrede, AF; Boer, VCJ; Gerrits, WJJ; Keijer, J1
Colvin, SC; Mastracci, TL; Mirmira, RG; Padgett, LR1
Grudnik, P; Wątor, E; Wilk, P1
Benelli, D; Catalanotto, C; La Teana, A; Londei, P; Martella, M; Talora, C1
Blondeau, N; Bourourou, M; Friard, J; Gouix, E; Heurteaux, C; Melis, N; Tauc, M1
Chen, M; Gai, Z; Okada, C; Yao, M; Ye, Y; Yu, J1
Assmann, N; Choi, C; Dettmer, K; Finlay, DK; Gardiner, CM; Keane, C; O'Brien, KL; O'Connor, E; Oefner, PJ; Walls, J1
Agostinelli, E; Bertani, C; Bordone, R; Canettieri, G; Coni, S; De Smaele, E; Di Magno, L; Di Marcotullio, L; Fatica, A; Giannini, G; Guerrieri, F; Ianniello, Z; Infante, P; Licursi, V; Macone, A; Maroder, M; Moretti, M; Petroni, M; Serrao, SM; Yurtsever, ZN1
Allaman, MM; Asim, M; Barry, DP; Calcutt, MW; Delagado, AG; Finley, JL; Gobert, AP; Latour, YL; Mirmira, RG; Piazuelo, MB; Rose, KL; Schey, KL; Sierra, JC; Smith, TM; Verriere, TG; Wilson, KT1
Alepuz, P; Barba-Aliaga, M; Corman, A; Martínez-Pastor, MT; Stanciu, A; Villarroel-Vicente, C1
Consonni, SR; de Lima, TI; Luchessi, AD; Pereira, KD; Silveira, LR; Tamborlin, L1
Amiel, J; Banka, S; Crilly, S; Cross, LA; Cuvertino, S; Davies, SJ; Douglas, AGL; Faundes, V; Fry, AE; Gordon, CT; Granadillo, JL; Harrison, V; Jennings, MD; Kasher, PR; Legraie, S; Lehalle, D; Newkirk, P; Newman, WG; Pavitt, GD; Ranells, J; Saunders, CJ; Splitt, M; Sullivan, BR; Withers, SE1
Jeelani, G; Nozaki, T1
Anderson-Baucum, EK; Connors, CT; Mastracci, TL; Mirmira, RG; Padgett, LR; Robertson, MA; Wu, W1
Beuschel, CB; Bogdanow, B; Conrad, TOF; Huang, S; Kintscher, U; Kollipara, L; Liang, Y; Liu, F; Lützkendorf, J; Madeo, F; Maglione, M; Piao, C; See, JCK; Sickmann, A; Sigrist, SJ; Toppe, D1
Baixauli, F; Balabanov, S; Buescher, JM; Corrado, M; Edwards-Hicks, J; Field, CS; Flachsmann, L; Green, DR; Grzes, KM; Haessler, F; Kabat, AM; Kamiński, MM; Kuchroo, VK; Mittler, G; Musa, Y; Pearce, EJ; Pearce, EL; Piletic, K; Puleston, DJ; Sanin, DE; Schimmelpfennig, L; Stanckzak, M; Villa, M; Wang, C; Weiss, HJ; Yosef, N1
Banka, S; Chung, WK; Kar, RK; Park, MH; Ziegler, A1
Hanner, AS; Kar, RK; Mastracci, TL; Mirmira, RG; Park, MH; Springer, D; Starost, MF1
Bézieau, S; Boland, A; Bonneau, D; Chung, WK; Coubes, C; Deleuze, JF; Faivre, L; Hanner, AS; Kar, RK; Küry, S; Le Mao, M; Lenaers, G; Maystadt, I; Navet, B; Park, MH; Prouteau, C; Rauch, A; Steindl, K; Tran Mau-Them, F; Zanoni, P; Ziegler, A1
Cruz-Pulido, YE; Mounce, BC1
Guimarães, DSPSF; Luchessi, AD; Pereira, KD; Silveira, LR; Tamborlin, L1

Reviews

22 review(s) available for hypusine and lysine

ArticleYear
Biosynthesis of hypusine in eIF-4D precursors.
    Advances in experimental medicine and biology, 1988, Volume: 250

    Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; RNA-Binding Proteins

1988
Hypusine biosynthesis in protein and its biological consequences.
    Advances in experimental medicine and biology, 1988, Volume: 250

    Topics: Animals; Humans; Lysine; Protein Biosynthesis

1988
Polyamines.
    Annual review of biochemistry, 1984, Volume: 53

    Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning, Molecular; DNA; Escherichia coli; Lysine; Mutation; Neoplasms; Neurospora crassa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Physarum; Plants; Polyamines; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Putrescine; RNA; Saccharomyces cerevisiae; Spermidine; Spermidine Synthase; Spermine; Spermine Synthase

1984
Is hypusine essential for eukaryotic cell proliferation?
    Trends in biochemical sciences, 1993, Volume: 18, Issue:12

    Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins; Spermidine

1993
Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.
    BioFactors (Oxford, England), 1993, Volume: 4, Issue:2

    Topics: Amino Acid Sequence; Animals; Cell Physiological Phenomena; Eukaryotic Translation Initiation Factor 5A; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger

1993
The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis.
    Amino acids, 2001, Volume: 20, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Drug Design; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger

2001
The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A).
    Journal of biochemistry, 2006, Volume: 139, Issue:2

    Topics: Animals; Catalysis; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Tertiary; RNA-Binding Proteins

2006
Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malaria.
    Mini reviews in medicinal chemistry, 2006, Volume: 6, Issue:11

    Topics: Animals; Antiparasitic Agents; Drug Design; Humans; Lysine; Malaria; Plasmodium; Polyamines

2006
Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Amino Acid Sequence; Animals; Binding Sites; Biological Evolution; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Elongation Factors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Alignment; Spermidine; Substrate Specificity

2007
Anticancer drugs and hyperthermia enhance cytotoxicity induced by polyamine enzymatic oxidation products.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Caspases; Cattle; Cell Proliferation; Docetaxel; Drug Synergism; Etoposide; Eukaryotic Translation Initiation Factor 5A; Humans; Hyperthermia, Induced; Interferon-alpha; Lysine; Ornithine Decarboxylase; Oxidation-Reduction; Peptide Initiation Factors; Polyamines; RNA-Binding Proteins; Taxoids

2007
Functional significance of eIF5A and its hypusine modification in eukaryotes.
    Amino acids, 2010, Volume: 38, Issue:2

    Topics: Animals; Bacteria; Bacterial Proteins; Eukaryota; Eukaryotic Translation Initiation Factor 5A; Fungal Proteins; Fungi; Humans; Lysine; Peptide Initiation Factors; Protein Structure, Secondary; RNA-Binding Proteins

2010
Hypusine: a new target for therapeutic intervention in diabetic inflammation.
    Discovery medicine, 2010, Volume: 10, Issue:50

    Topics: Animals; Diabetes Complications; Eukaryotic Translation Initiation Factor 5A; Humans; Inflammation; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Transport; RNA-Binding Proteins

2010
Unique modifications of translation elongation factors.
    The FEBS journal, 2011, Volume: 278, Issue:15

    Topics: Animals; Eukaryotic Initiation Factor-5; Histidine; Humans; Lysine; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Phosphatidylethanolamines; Protein Processing, Post-Translational

2011
eIF5A isoforms and cancer: two brothers for two functions?
    Amino acids, 2013, Volume: 44, Issue:1

    Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Neoplasms; Peptide Initiation Factors; Protein Isoforms; RNA-Binding Proteins

2013
Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: understanding the action of the inhibitor GC7 on a murine macrophage cell line.
    Current pharmaceutical design, 2014, Volume: 20, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Inflammation; Lysine; Macrophages; Mice; Molecular Targeted Therapy; Nitric Oxide; Peptide Initiation Factors; RNA-Binding Proteins

2014
The translation factor eIF5A and human cancer.
    Biochimica et biophysica acta, 2015, Volume: 1849, Issue:7

    Topics: Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Humans; Lysine; Neoplasms; Oncogene Proteins; Peptide Chain Elongation, Translational; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Protein Isoforms; Protein Processing, Post-Translational; RNA-Binding Proteins

2015
Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer.
    Amino acids, 2016, Volume: 48, Issue:10

    Topics: Animals; Biogenic Polyamines; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Neoplasm Proteins; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins

2016
Translation Factor eIF5A, Modification with Hypusine and Role in Regulation of Gene Expression. eIF5A as a Target for Pharmacological Interventions.
    Biochemistry. Biokhimiia, 2018, Volume: 83, Issue:8

    Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Humans; Lysine; Molecular Targeted Therapy; Peptide Initiation Factors; Protein Biosynthesis; RNA-Binding Proteins

2018
Hypusine, a polyamine-derived amino acid critical for eukaryotic translation.
    The Journal of biological chemistry, 2018, 11-30, Volume: 293, Issue:48

    Topics: Animals; Eukaryota; Humans; Lysine; Polyamines; Protein Biosynthesis

2018
The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine.
    Nutrients, 2020, Jan-11, Volume: 12, Issue:1

    Topics: Animals; Colon; Dietary Proteins; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; Polyamines; Protein Biosynthesis; RNA-Binding Proteins; Transcription, Genetic

2020
Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
    Amino acids, 2022, Volume: 54, Issue:4

    Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mice; Neurodevelopmental Disorders; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins

2022
Good cop, bad cop: Polyamines play both sides in host immunity and viral replication.
    Seminars in cell & developmental biology, 2023, 09-15, Volume: 146

    Topics: Adaptive Immunity; Antineoplastic Agents; Antiviral Agents; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Host Microbial Interactions; Humans; Lysine; Polyamines; Protein Processing, Post-Translational; Virus Diseases; Virus Replication; Viruses

2023

Other Studies

163 other study(ies) available for hypusine and lysine

ArticleYear
Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion.
    The Biochemical journal, 1992, Nov-01, Volume: 287 ( Pt 3)

    Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Deoxyadenosines; Kinetics; Leukemia L1210; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Tumor Cells, Cultured

1992
Determination of the unusual amino acid hypusine at the lower picomole level by derivatization with 4-dimethylaminoazobenzene-4'-sulphonyl chloride and reversed-phase high-performance or medium-pressure liquid chromatography.
    Journal of chromatography, 1992, Jul-31, Volume: 606, Issue:1

    Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, High Pressure Liquid; Chromatography, Liquid; Indicators and Reagents; Lysine; Molecular Sequence Data; p-Dimethylaminoazobenzene; Spectrophotometry, Ultraviolet; Sulfolobus acidocaldarius; Trypsin

1992
The archaebacterial hypusine-containing protein. Structural features suggest common ancestry with eukaryotic translation initiation factor 5A.
    European journal of biochemistry, 1992, Mar-01, Volume: 204, Issue:2

    Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, Ion Exchange; Cloning, Molecular; Cyanogen Bromide; Diazonium Compounds; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Indicators and Reagents; Isoelectric Focusing; Lysine; Molecular Sequence Data; Oligonucleotide Probes; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Alignment; Sulfanilic Acids; Sulfolobus

1992
Differential expression of genes encoding the hypusine-containing translation initiation factor, eIF-5A, in tobacco.
    Nucleic acids research, 1992, Feb-25, Volume: 20, Issue:4

    Topics: Amino Acid Sequence; Blotting, Northern; Blotting, Western; Cloning, Molecular; Eukaryotic Initiation Factor-5; Gene Expression; Lysine; Molecular Sequence Data; Nicotiana; Peptide Initiation Factors; Plants, Toxic; Sequence Alignment

1992
Two isoforms of eIF-5A in chick embryo. Isolation, activity, and comparison of sequences of the hypusine-containing proteins.
    The Journal of biological chemistry, 1992, Mar-25, Volume: 267, Issue:9

    Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chick Embryo; Chickens; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Genetic Variation; Humans; Lysine; Male; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Putrescine; Rabbits; RNA-Binding Proteins; Sequence Homology, Nucleic Acid; Spermidine; Tritium

1992
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
    The Journal of biological chemistry, 1991, May-05, Volume: 266, Issue:13

    Topics: Animals; Cadaverine; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; Eflornithine; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Periodic Acid; Puromycin; RNA-Binding Proteins; Spermidine; Substrate Specificity

1991
Isolation and identification of alpha-(beta-alanyl)hypusine from bovine brain.
    Biochimica et biophysica acta, 1991, Jan-23, Volume: 1073, Issue:1

    Topics: Animals; beta-Alanine; Brain Chemistry; Cattle; Dipeptides; Lysine

1991
Eukaryotic initiation factor 5A: the molecular form of the hypusine-containing protein from human erythrocytes.
    Biochimica et biophysica acta, 1991, Feb-15, Volume: 1076, Issue:3

    Topics: Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Denaturation; RNA-Binding Proteins

1991
Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.
    Molecular and cellular biology, 1991, Volume: 11, Issue:6

    Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Cloning, Molecular; Codon; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Genetic Vectors; Humans; Kinetics; Lysine; Mitochondria; Molecular Sequence Data; Oligonucleotide Probes; Peptide Initiation Factors; Phenotype; Plasmids; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid

1991
High-performance liquid chromatographic method for determination of hypusine and deoxyhypusine.
    Analytical biochemistry, 1990, Volume: 184, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Lysine; Male; Microchemistry; Rats; Rats, Inbred Strains; Regression Analysis; Reproducibility of Results; Spectrometry, Fluorescence

1990
Polyamine-dependent post-translational modification of proteins in differentiating mouse epidermal cells.
    The Journal of investigative dermatology, 1990, Volume: 94, Issue:5

    Topics: Animals; Cell Differentiation; Epidermal Cells; Keratinocytes; Lysine; Mice; Mice, Inbred BALB C; Polyamines; Protein Processing, Post-Translational; Spermidine

1990
The role of mammalian initiation factor eIF-4D and its hypusine modification in translation.
    Biochimica et biophysica acta, 1990, Aug-27, Volume: 1050, Issue:1-3

    Topics: Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Kinetics; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; Puromycin; RNA-Binding Proteins; RNA, Transfer, Met

1990
Characterization and reconstitution of a cell free system for NAD(+)-dependent deoxyhypusine formation on the 18 kDa eIF-4D precursor.
    Biochimica et biophysica acta, 1990, Nov-09, Volume: 1036, Issue:2

    Topics: Animals; Cell Line; Cell-Free System; Eukaryotic Translation Initiation Factor 5A; Lysine; Mice; Molecular Weight; NAD; Neuroblastoma; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins

1990
Deoxyhypusine/hypusine formation on a 21,000-dalton cellular protein in a Neurospora crassa mutant in vivo and in vitro.
    Biochimica et biophysica acta, 1990, Feb-26, Volume: 1033, Issue:2

    Topics: Electrophoresis, Polyacrylamide Gel; Fungal Proteins; Isoelectric Focusing; Lysine; Mutation; Neurospora; Neurospora crassa; Polyamines

1990
Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.
    The Journal of biological chemistry, 1989, Jan-25, Volume: 264, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cloning, Molecular; DNA; Eukaryotic Translation Initiation Factor 5A; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Protein Conformation; Rabbits; RNA-Binding Proteins

1989
Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Arginine; Codon; DNA; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Mutation; Nucleic Acid Hybridization; Peptide Initiation Factors; Plasmids; RNA-Binding Proteins; Structure-Activity Relationship; Transfection

1989
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Animals; Cell Line; Cricetinae; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; Putrescine; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship

1989
cDNA and derived amino acid sequence of the hypusine containing protein from Dictyostelium discoideum.
    FEBS letters, 1989, Mar-27, Volume: 246, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Chromatography, Affinity; Codon; Cyanogen Bromide; Dictyostelium; DNA; DNA Restriction Enzymes; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Immunoassay; Lysine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Nucleic Acid Hybridization; Peptide Fragments; Peptide Initiation Factors; RNA-Binding Proteins; RNA, Messenger; Trypsin

1989
Age dependency of the metabolic conversion of polyamines into amino acids in IMR-90 human embryonic lung diploid fibroblasts.
    Journal of cellular physiology, 1986, Volume: 128, Issue:1

    Topics: Amino Acids; Cell Line; Cell Survival; Diploidy; Eflornithine; Enzyme Induction; Fibroblasts; Humans; Lysine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Processing, Post-Translational; Putrescine

1986
Indirect assays for deoxyhypusine hydroxylase using dual-label ratio changes and oxidative release of radioactivity.
    Analytical biochemistry, 1986, May-01, Volume: 154, Issue:2

    Topics: Carbon Radioisotopes; Isotope Labeling; Lysine; Mixed Function Oxygenases; Oxidation-Reduction; Time Factors; Tritium

1986
Changes in eIF-4D hypusine modification or abundance are not correlated with translational repression in HeLa cells.
    The Journal of biological chemistry, 1986, Sep-25, Volume: 261, Issue:27

    Topics: Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Hot Temperature; Humans; Lysine; Peptide Initiation Factors; Protein Biosynthesis; RNA-Binding Proteins; Saline Solution, Hypertonic

1986
Biosynthetic labeling of hypusine in mammalian cells. Carbon-hydrogen bond fissions revealed by dual labeling.
    The Journal of biological chemistry, 1986, Oct-25, Volume: 261, Issue:30

    Topics: Animals; Carbon Radioisotopes; Cell Line; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Ovary; Protein Processing, Post-Translational; Tritium

1986
Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.
    The Journal of biological chemistry, 1986, Nov-05, Volume: 261, Issue:31

    Topics: Amino Acid Sequence; Erythrocytes; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Weight; Peptide Initiation Factors; Peptide Mapping; RNA-Binding Proteins

1986
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
    The Biochemical journal, 1986, Oct-15, Volume: 239, Issue:2

    Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Rats; RNA-Binding Proteins; Spermidine; Spermine

1986
Proteins associated with B lymphocyte hyperactivity in New Zealand black mice.
    Journal of immunology (Baltimore, Md. : 1950), 1987, Jun-01, Volume: 138, Issue:11

    Topics: Amino Acid Sequence; Animals; Autoimmune Diseases; B-Lymphocytes; Isoelectric Point; Lysine; Mice; Mice, Inbred NZB; Molecular Weight; Protein Biosynthesis

1987
The formation and stability of the hypusine containing protein in Chinese hamster ovary cells.
    Biochemical and biophysical research communications, 1987, Jun-30, Volume: 145, Issue:3

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Lysine; Molecular Weight; Ovary; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Spermine

1987
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.
    The Journal of biological chemistry, 1987, Sep-15, Volume: 262, Issue:26

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Eflornithine; Female; Fibroblasts; Gene Expression Regulation; Lysine; Ovary; Protein Biosynthesis; Protein Processing, Post-Translational; Spermidine

1987
Hypusine formation in protein by a two-step process in cell lysates.
    The Journal of biological chemistry, 1987, Nov-05, Volume: 262, Issue:31

    Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Hydrogen-Ion Concentration; Kinetics; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Polyamines; Protein Processing, Post-Translational; Rats; RNA-Binding Proteins

1987
Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.
    The Journal of biological chemistry, 1987, Dec-05, Volume: 262, Issue:34

    Topics: Amino Acids; Animals; Cells; Drosophila melanogaster; Escherichia coli; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Peptide Mapping; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine

1987
Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates or specificity of protein synthesis is altered.
    The Journal of biological chemistry, 1987, Dec-05, Volume: 262, Issue:34

    Topics: Animals; Drosophila melanogaster; Eukaryotic Translation Initiation Factor 5A; Fluorometry; Hot Temperature; Lysine; Peptide Initiation Factors; Protein Biosynthesis; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae; Spores, Fungal

1987
NAD+ stimulated the spermidine-dependent hypusine formation on the 18 kDa protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.
    FEBS letters, 1988, Mar-14, Volume: 229, Issue:2

    Topics: Animals; Cell Line; Cytosol; Lysine; Mice; Molecular Weight; NAD; Nerve Tissue Proteins; Neuroblastoma; Putrescine; Spermidine; Tritium

1988
The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells.
    The Journal of biological chemistry, 1988, Jun-05, Volume: 263, Issue:16

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Isoelectric Point; Lysine; Ovary; Peptide Initiation Factors; Peptide Mapping; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine

1988
Isolation and characterization of an 18 kDa hypusine-containing protein from cultured NB-15 mouse neuroblastoma cells.
    Biochimica et biophysica acta, 1988, Aug-19, Volume: 971, Issue:1

    Topics: Adsorption; Animals; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Lysine; Mice; Molecular Weight; Neoplasm Proteins; Neuroblastoma; Peptide Initiation Factors; Polynucleotides; Rabbits; Reticulocytes; RNA-Binding Proteins; Tumor Cells, Cultured

1988
Post-translational formation of hypusine: biogenesis of translation initiation factor eIF-4D.
    Advances in experimental medicine and biology, 1988, Volume: 231

    Topics: Animals; Eukaryotic Initiation Factor-4F; Gene Expression Regulation; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Putrescine; Spermidine

1988
Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:7

    Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Humans; Isoelectric Point; Lysine; Mice; Molecular Weight; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins

1983
The mammalian hypusine-containing protein, eukaryotic initiation factor 4D. Structural homology of this protein from several species.
    The Journal of biological chemistry, 1984, Apr-10, Volume: 259, Issue:7

    Topics: Animals; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Female; Humans; Lymphocytes; Lysine; Molecular Weight; Ovary; Peptide Fragments; Peptide Initiation Factors; RNA-Binding Proteins; Trypsin

1984
Hydralazine inhibition of the post-translational hydroxylation of deoxyhypusine, a polyamine-derived amino acid.
    Biochemical pharmacology, 1984, Mar-01, Volume: 33, Issue:5

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Replication; Female; Hydralazine; Hydroxylation; Lysine; Ovary; Protein Biosynthesis; Putrescine

1984
A rapid and sensitive method for the determination of hypusine in proteins and its distribution and developmental changes.
    Biochimica et biophysica acta, 1984, Jul-30, Volume: 800, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Liver; Lysine; Male; Methods; Protein Processing, Post-Translational; Proteins; Rats; Rats, Inbred Strains; Subcellular Fractions; Tissue Distribution

1984
Cellular proliferation and hypusine synthesis.
    Experimental cell research, 1984, Volume: 154, Issue:2

    Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Culture Media; DNA; Female; Fibroblasts; Humans; Kinetics; Lysine; Ovary; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine

1984
The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.
    The Journal of biological chemistry, 1984, Oct-10, Volume: 259, Issue:19

    Topics: Animals; Butylamines; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Mass Spectrometry; Putrescine; Spermidine

1984
Hypusine formation: a unique posttranslational modification in translation initiation factor eIF-4D.
    Methods in enzymology, 1984, Volume: 106

    Topics: Animals; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Humans; Lymphocytes; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; Radioisotope Dilution Technique; Reticulocytes; RNA-Binding Proteins; Spermidine; Tritium

1984
Posttranslational formation of hypusine in a single major protein occurs generally in growing cells and is associated with activation of lymphocyte growth.
    Cell, 1982, Volume: 29, Issue:3

    Topics: Amino Acids; Animals; Cell Division; Cells, Cultured; Cricetinae; Isoelectric Point; Lymphocyte Activation; Lymphocytes; Lysine; Mice; Molecular Weight; Protein Processing, Post-Translational; Proteins

1982
Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.
    Biochemistry, 1995, Nov-14, Volume: 34, Issue:45

    Topics: Amino Acid Sequence; Chromatography, Gel; Circular Dichroism; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Lysine; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Secondary; RNA-Binding Proteins

1995
The polypeptide chain of eukaryotic initiation factor 5A occurs in two distinct conformations in the absence of the hypusine modification.
    Biochemistry, 1995, Nov-14, Volume: 34, Issue:45

    Topics: Chromatography, Gel; Circular Dichroism; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Guanidine; Guanidines; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Osmolar Concentration; Peptide Initiation Factors; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; RNA-Binding Proteins

1995
Detection of nonfunctional overexpression gene products using two-dimensional gel electrophoresis with a narrowed pH range.
    Electrophoresis, 1995, Volume: 16, Issue:5

    Topics: Electrophoresis, Gel, Two-Dimensional; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Hydrogen-Ion Concentration; Lysine; Saccharomyces cerevisiae

1995
Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme.
    The Journal of biological chemistry, 1995, Aug-04, Volume: 270, Issue:31

    Topics: Amino Acid Sequence; Animals; Base Sequence; Chromosomes, Fungal; DNA, Complementary; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Fungal Proteins; Genes, Fungal; Humans; Lysine; Male; Molecular Sequence Data; Molecular Weight; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polymerase Chain Reaction; Rats; Recombinant Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Testis

1995
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
    Journal of medicinal chemistry, 1995, Aug-04, Volume: 38, Issue:16

    Topics: Animals; Binding, Competitive; Cell Division; CHO Cells; Cricetinae; Cricetulus; Diamines; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Rats; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship; Testis

1995
Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication.
    FEBS letters, 1995, Jun-12, Volume: 366, Issue:2-3

    Topics: Base Sequence; Cell Line; DNA Replication; Electron Transport Complex IV; Eukaryotic Translation Initiation Factor 5A; G1 Phase; Humans; Lymphocytes; Lysine; Methionine Adenosyltransferase; Mimosine; Mixed Function Oxygenases; Molecular Sequence Data; Peptide Initiation Factors; Polyribosomes; RNA-Binding Proteins; RNA, Messenger; S Phase; Sequence Alignment

1995
Identification of a substrate site for transglutaminases on the human protein synthesis initiation factor 5A.
    The Biochemical journal, 1995, Feb-01, Volume: 305 ( Pt 3)

    Topics: Animals; Binding Sites; Caseins; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Eukaryotic Translation Initiation Factor 5A; Glutamic Acid; Guinea Pigs; Humans; Kinetics; Liver; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Transglutaminases

1995
Cloning and sequencing of a chick embryo cDNA encoding the 20-kDa hypusine-containing protein, eIF-5A.
    Gene, 1993, Dec-31, Volume: 137, Issue:2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Chick Embryo; Cloning, Molecular; DNA, Complementary; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Rabbits; RNA-Binding Proteins

1993
Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.
    The Journal of biological chemistry, 1994, Nov-11, Volume: 269, Issue:45

    Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Diamines; Dose-Response Relationship, Drug; Guanine; Indicators and Reagents; Kinetics; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine; Structure-Activity Relationship

1994
The function of the hypusine-containing proteins of yeast and other eukaryotes is well conserved.
    Molecular & general genetics : MGG, 1994, Sep-28, Volume: 244, Issue:6

    Topics: Anaerobiosis; Blotting, Western; Fungal Proteins; Genes, Fungal; Lysine; Mutation; Plasmids; Polymerase Chain Reaction; Protein Biosynthesis; Saccharomyces cerevisiae

1994
Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Nov-08, Volume: 91, Issue:23

    Topics: Base Sequence; Cell Division; Cell Line; Cells, Cultured; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Gene Expression; HIV Infections; Humans; In Vitro Techniques; Lymphocyte Activation; Lysine; Molecular Sequence Data; Peptide Chain Initiation, Translational; Peptide Initiation Factors; RNA-Binding Proteins; RNA, Messenger; T-Lymphocytes; Time Factors

1994
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
    The Biochemical journal, 1994, Oct-15, Volume: 303 ( Pt 2)

    Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Leukemia L1210; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine; Spermine; Substrate Specificity; Tumor Cells, Cultured

1994
Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation.
    Biochimica et biophysica acta, 1994, Mar-31, Volume: 1221, Issue:2

    Topics: Alanine; Amino Acid Sequence; Animals; Cell Division; Cell Line; Cell Line, Transformed; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; G1 Phase; Humans; Lysine; Mimosine; Mixed Function Oxygenases; Molecular Sequence Data; Peptide Initiation Factors; Pyrones; RNA-Binding Proteins; S Phase; Sequence Alignment; Structure-Activity Relationship

1994
Determination and mutational analysis of the phosphorylation site in the hypusine-containing protein Hyp2p.
    FEBS letters, 1993, Nov-22, Volume: 334, Issue:3

    Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Fungal Proteins; Lysine; Mass Spectrometry; Molecular Sequence Data; Phosphorylation; Polymerase Chain Reaction; Saccharomyces cerevisiae

1993
The HYP2 gene of Saccharomyces cerevisiae is essential for aerobic growth: characterization of different isoforms of the hypusine-containing protein Hyp2p and analysis of gene disruption mutants.
    Molecular & general genetics : MGG, 1993, Volume: 241, Issue:3-4

    Topics: Aerobiosis; Anaerobiosis; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Fungal Proteins; Genes, Fungal; Lysine; Mutation; Saccharomyces cerevisiae

1993
Translation initiation factor eIF-5A expressed from either of two yeast genes or from human cDNA. Functional identity under aerobic and anaerobic conditions.
    The Journal of biological chemistry, 1993, Jul-05, Volume: 268, Issue:19

    Topics: Aerobiosis; Anaerobiosis; Base Sequence; Conserved Sequence; DNA; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Genes, Fungal; Genetic Variation; Humans; Kinetics; Lysine; Peptide Initiation Factors; Promoter Regions, Genetic; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae

1993
Translation initiation factor eIF-5A, the hypusine-containing protein, is phosphorylated on serine in Saccharomyces cerevisiae.
    The Journal of biological chemistry, 1993, Jul-15, Volume: 268, Issue:20

    Topics: Base Sequence; Blotting, Western; DNA, Single-Stranded; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Isoelectric Focusing; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Phosphorylation; Precipitin Tests; Protein Precursors; Puromycin; RNA-Binding Proteins; Saccharomyces cerevisiae; Serine

1993
Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay.
    FEBS letters, 1996, Feb-19, Volume: 380, Issue:3

    Topics: Chelating Agents; Cobalt; Copper; Eukaryotic Translation Initiation Factor 5A; Ferric Compounds; Ferrous Compounds; HeLa Cells; Humans; Lysine; Manganese; Metals; Mixed Function Oxygenases; Nickel; Oxidation-Reduction; Peptide Initiation Factors; RNA-Binding Proteins; Zinc

1996
Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae.
    FEBS letters, 1996, Apr-15, Volume: 384, Issue:2

    Topics: Amino Acid Sequence; Base Sequence; Cell Survival; Cloning, Molecular; Eukaryotic Translation Initiation Factor 5A; Fungal Proteins; Genes, Fungal; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Saccharomyces cerevisiae

1996
Determination of covalently bound hypusine and deoxyhypusine to protein using submilligram of protein samples by HPLC.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chromatography, High Pressure Liquid; Lysine; Protein Binding; Rats; Reference Standards; Tumor Cells, Cultured

1996
Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs.
    The Biochemical journal, 1996, Nov-15, Volume: 320 ( Pt 1)

    Topics: Animals; Cell Division; Cell Line; Eukaryotic Translation Initiation Factor 5A; Lysine; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Rodentia

1996
Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts.
    Journal of cellular physiology, 1997, Volume: 170, Issue:3

    Topics: Antineoplastic Agents; Cells, Cultured; Cellular Senescence; Diploidy; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Lung; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Substrate Specificity

1997
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
    Cancer letters, 1997, May-19, Volume: 115, Issue:2

    Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Lysine; Mice; Oncogene Protein p21(ras); Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine

1997
Interferon alpha2 recombinant and epidermal growth factor modulate proliferation and hypusine synthesis in human epidermoid cancer KB cells.
    The Biochemical journal, 1997, Jun-15, Volume: 324 ( Pt 3)

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Epidermal Growth Factor; Exotoxins; Humans; Interferon alpha-2; Interferon-alpha; Lysine; Ornithine Decarboxylase; Oropharyngeal Neoplasms; Recombinant Proteins; Transforming Growth Factor alpha; Tumor Cells, Cultured

1997
Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis.
    The Biochemical journal, 1997, Dec-15, Volume: 328 ( Pt 3)

    Topics: Animals; Apoptosis; Cell Division; Diamines; Eflornithine; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Lysine; Microscopy, Electron; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Peptide Initiation Factors; Polyamines; Protein Processing, Post-Translational; Putrescine; Rats; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured

1997
Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1).
    Biochemical pharmacology, 1998, Jun-01, Volume: 55, Issue:11

    Topics: Anti-HIV Agents; Apoptosis; Cell Line, Transformed; Deferiprone; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; HIV Core Protein p24; HIV-1; Humans; Lysine; Microscopy, Electron; Mimosine; Mixed Function Oxygenases; Peptide Initiation Factors; Pyridones; RNA-Binding Proteins; RNA, Messenger; RNA, Viral; T-Lymphocytes; Virus Replication

1998
Synthesis of reagents for the construction of hypusine and deoxyhypusine peptides and their application as peptidic antigens.
    Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20

    Topics: Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Eukaryotic Translation Initiation Factor 5A; Haptens; Hemocyanins; Humans; Lysine; Maleimides; Mice; Mice, Inbred BALB C; Oligopeptides; Ovalbumin; Peptide Initiation Factors; RNA-Binding Proteins; Stereoisomerism

1998
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
    Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20

    Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured

1998
Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells.
    FEBS letters, 1998, Oct-16, Volume: 437, Issue:1-2

    Topics: 3T3 Cells; Animals; Cell Division; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Lysine; Mice; Mice, Inbred BALB C; Peptide Initiation Factors; Polyamines; RNA-Binding Proteins; Time Factors; Transfection; Transglutaminases

1998
Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation.
    Yeast (Chichester, England), 1999, Jan-15, Volume: 15, Issue:1

    Topics: Amino Acid Sequence; Animals; Binding Sites; Humans; Lysine; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; Saccharomyces cerevisiae

1999
Cloning and analysis of cDNAs encoding the hypusine-containing protein eIF5A of two lepidopteran insect species.
    Insect molecular biology, 1999, Volume: 8, Issue:4

    Topics: Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Cloning, Molecular; DNA, Complementary; Eukaryotic Translation Initiation Factor 5A; Gene Dosage; Gene Expression; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Spodoptera

1999
Cell cycle arrest in archaea by the hypusination inhibitor N(1)-guanyl-1,7-diaminoheptane.
    Journal of bacteriology, 2000, Volume: 182, Issue:4

    Topics: Cell Cycle; Enzyme Inhibitors; Escherichia coli; Flow Cytometry; Guanine; Lysine; Sulfolobus acidocaldarius

2000
Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy.
    Advances in experimental medicine and biology, 1999, Volume: 472

    Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Chelating Agents; Cytarabine; Deferoxamine; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Translation Initiation Factor 5A; Exotoxins; Humans; Interferon-gamma; Iron; Kinetics; Leukemia; Lysine; Oropharyngeal Neoplasms; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Transforming Growth Factor alpha; Tumor Cells, Cultured

1999
Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA.
    The Journal of experimental medicine, 2000, May-01, Volume: 191, Issue:9

    Topics: Antigen Presentation; Antigens, CD; Biological Transport; CD83 Antigen; Cell Compartmentation; Cell Differentiation; Cell Nucleus; Dendritic Cells; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Immunoglobulins; Lymphocyte Activation; Lysine; Membrane Glycoproteins; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger; T-Lymphocytes; Up-Regulation

2000
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
    The EMBO journal, 2000, Aug-15, Volume: 19, Issue:16

    Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Nucleus; Chromatography, Affinity; Cloning, Molecular; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Eukaryotic Translation Initiation Factor 5A; GTP Phosphohydrolases; HeLa Cells; Humans; Karyopherins; Kinetics; Lysine; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Nuclear Proteins; Peptide Initiation Factors; Protein Binding; Protein Structure, Tertiary; ran GTP-Binding Protein; RNA; RNA-Binding Proteins; Time Factors

2000
Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with postsystematic evolution of ligands by exponential enrichment RNA.
    The Journal of biological chemistry, 2001, Jan-26, Volume: 276, Issue:4

    Topics: Base Sequence; Consensus Sequence; Directed Molecular Evolution; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Gene Products, rev; Humans; Ligands; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Response Elements; RNA; RNA-Binding Proteins

2001
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
    The Biochemical journal, 2000, Dec-15, Volume: 352 Pt 3

    Topics: Binding Sites; Eukaryotic Initiation Factor-5; Humans; Hydrogen-Ion Concentration; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Spermidine; Substrate Specificity; Time Factors

2000
Asymmetric synthesis of (+)-hypusine.
    Organic letters, 2001, Dec-27, Volume: 3, Issue:26

    Topics: Amino Acid Sequence; Lysine; Magnetic Resonance Spectroscopy; Molecular Structure

2001
Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin.
    The Biochemical journal, 2002, May-01, Volume: 363, Issue:Pt 3

    Topics: Animals; Antibiotics, Antineoplastic; Eukaryotic Translation Initiation Factor 5A; Female; Guanidines; Lysine; Mice; Models, Chemical; Peptide Initiation Factors; Putrescine; RNA Caps; RNA-Binding Proteins; RNA, Messenger; Spermidine; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging.
    Journal of cellular biochemistry, 2002, Volume: 86, Issue:3

    Topics: 3T3 Cells; Active Transport, Cell Nucleus; Animals; Calnexin; Cell Nucleus; Cell Survival; COS Cells; Eukaryotic Initiation Factors; Eukaryotic Translation Initiation Factor 5A; Exportin 1 Protein; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins; HeLa Cells; Humans; Karyopherins; Luminescent Proteins; Lysine; Mice; Nuclear Localization Signals; Peptide Initiation Factors; Protein Transport; Receptors, Cytoplasmic and Nuclear; RNA-Binding Proteins

2002
Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis.
    Molecular and cellular biochemistry, 2002, Volume: 237, Issue:1-2

    Topics: Apoptosis; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Humans; Laminin; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Proteoglycans; RNA-Binding Proteins; Time Factors; Umbilical Veins

2002
Crystal structure of hyperthermophilic archaeal initiation factor 5A: a homologue of eukaryotic initiation factor 5A (eIF-5A).
    Journal of biochemistry, 2003, Volume: 133, Issue:1

    Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Eukaryotic Translation Initiation Factor 5A; Lysine; Models, Molecular; Molecular Sequence Data; Peptide Initiation Factors; Protein Structure, Tertiary; RNA; RNA-Binding Proteins; Sequence Homology, Amino Acid; Structural Homology, Protein

2003
The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-alpha and EGF in human cancer cells.
    Journal of biochemistry, 2003, Volume: 133, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Combinations; Epidermal Growth Factor; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Interferon-alpha; KB Cells; Lysine; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphorylation; Protein Processing, Post-Translational; RNA-Binding Proteins

2003
Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.
    Oncogene, 2003, Jul-31, Volume: 22, Issue:31

    Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Diamines; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Megakaryoblastic, Acute; Leupeptins; Lysine; Multienzyme Complexes; Oligodeoxyribonucleotides, Antisense; Peptide Initiation Factors; Peptide Mapping; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteomics; RNA-Binding Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subcellular Fractions; Tumor Cells, Cultured; Ubiquitin

2003
[The effect of eIF-5A on the G1-S in cell cycle regulation].
    Zhongguo shi yan xue ye xue za zhi, 2003, Volume: 11, Issue:4

    Topics: Cell Line, Tumor; Diamines; Eukaryotic Translation Initiation Factor 5A; G1 Phase; Humans; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; S Phase

2003
Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Base Sequence; DNA, Fungal; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Kinetics; Lysine; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamine Oxidase; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spermidine; Spermine; Substrate Specificity

2003
Independent roles of eIF5A and polyamines in cell proliferation.
    The Biochemical journal, 2005, Feb-01, Volume: 385, Issue:Pt 3

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cyclohexylamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Half-Life; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Putrescine; Rats; RNA-Binding Proteins; Spermine

2005
Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy.
    The Journal of clinical investigation, 2005, Volume: 115, Issue:1

    Topics: Anti-HIV Agents; Cells, Cultured; Drug Resistance, Multiple; Gene Expression Regulation, Viral; Gene Products, rev; HIV Infections; HIV-1; Humans; Hydrazones; Kinetics; Lysine; Macrophages; Oxidoreductases Acting on CH-NH Group Donors; Phenotype; rev Gene Products, Human Immunodeficiency Virus; RNA Interference; T-Lymphocytes; Transcriptional Activation; Virus Replication

2005
Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex.
    Journal of cellular biochemistry, 2006, Feb-15, Volume: 97, Issue:3

    Topics: Arginine; Binding Sites; Chromatography, Affinity; Eukaryotic Translation Initiation Factor 5A; Humans; Ligands; Lysine; Mass Spectrometry; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Ribosomal Proteins; Ribosomes; RNA-Binding Proteins

2006
Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.
    The FEBS journal, 2006, Volume: 273, Issue:6

    Topics: Base Sequence; Cell Line; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Sequence Data; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyadenylation; Polyribosomes; Protein Biosynthesis; Protein Isoforms; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger; Transfection

2006
eIF5A binds to translational machinery components and affects translation in yeast.
    Biochemical and biophysical research communications, 2006, Oct-06, Volume: 348, Issue:4

    Topics: Eukaryotic Translation Initiation Factor 5A; Lysine; Mutation; Peptide Chain Elongation, Translational; Peptide Initiation Factors; Protein Biosynthesis; Protein Synthesis Inhibitors; Ribosomes; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

2006
Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach.
    Blood, 2007, Feb-15, Volume: 109, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Proliferation; Down-Regulation; Drug Delivery Systems; Drug Synergism; Eukaryotic Translation Initiation Factor 5A; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; K562 Cells; Leukemia; Lysine; Peptide Initiation Factors; Piperazines; Protein Processing, Post-Translational; Proteomics; Pyrimidines; RNA-Binding Proteins

2007
Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Mar-06, Volume: 104, Issue:10

    Topics: Animals; Arginase; Cell Proliferation; Cell Survival; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Hippocampus; Lysine; Models, Biological; Nerve Growth Factor; Neurons; PC12 Cells; Peptide Initiation Factors; Polyamines; Rats; RNA-Binding Proteins

2007
An archaeal protein with homology to the eukaryotic translation initiation factor 5A shows ribonucleolytic activity.
    The Journal of biological chemistry, 2007, May-11, Volume: 282, Issue:19

    Topics: Amino Acid Sequence; Archaeal Proteins; Base Sequence; Cells, Cultured; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Genetic Vectors; Halobacterium; Ligands; Lysine; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Initiation Factors; Protein Processing, Post-Translational; Ribonucleases; RNA-Binding Proteins; RNA, Archaeal; RNA, Messenger; Sequence Homology, Nucleic Acid

2007
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
    The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48

    Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Models, Biological; Pancreatitis; Peptide Initiation Factors; Polyamines; Rats; Recombinant Proteins; RNA-Binding Proteins; Spermidine; Stereoisomerism

2007
Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.
    The FEBS journal, 2008, Volume: 275, Issue:1

    Topics: Amino Acid Sequence; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Mutation; Peptide Initiation Factors; Protein Modification, Translational; RNA-Binding Proteins; Saccharomyces cerevisiae

2008
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, May-06, Volume: 105, Issue:18

    Topics: Eukaryotic Translation Initiation Factor 5A; Intracellular Space; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine; Tritium

2008
Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation.
    Journal of cellular physiology, 2009, Volume: 218, Issue:3

    Topics: Animals; Arginine; Cell Differentiation; Cell Proliferation; Chromatin; Connectin; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Guanine; Lysine; Male; Muscle Proteins; Muscle, Skeletal; MyoD Protein; Oxidation-Reduction; Peptide Initiation Factors; Protein Biosynthesis; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Satellite Cells, Skeletal Muscle; Stem Cells

2009
Dimerization of the yeast eukaryotic translation initiation factor 5A requires hypusine and is RNA dependent.
    The FEBS journal, 2009, Volume: 276, Issue:3

    Topics: Crystallography, X-Ray; Eukaryotic Translation Initiation Factor 5A; Lysine; Models, Molecular; Neurospora crassa; Peptide Initiation Factors; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; RNA-Binding Proteins; RNA, Fungal; Saccharomyces cerevisiae

2009
Cloning and characterization of hypusine-containing protein eIF5A from the olive flounder Paralichthys olivaceus.
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2009, Volume: 153, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Eukaryotic Translation Initiation Factor 5A; Flounder; Glycoproteins; Guanine; Kidney; Lysine; Molecular Sequence Data; Novirhabdovirus; Peptide Initiation Factors; Phylogeny; RNA-Binding Proteins; Viral Proteins

2009
The effect of hypusine modification on the intracellular localization of eIF5A.
    Biochemical and biophysical research communications, 2009, Jun-12, Volume: 383, Issue:4

    Topics: Acetylation; Cell Line; Cytoplasm; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mutation; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins

2009
Hypusine-containing protein eIF5A promotes translation elongation.
    Nature, 2009, May-07, Volume: 459, Issue:7243

    Topics: Eukaryotic Translation Initiation Factor 5A; Indenes; Lysine; Mutation; Peptide Chain Elongation, Translational; Peptide Elongation Factors; Peptide Initiation Factors; Polyribosomes; Protein Synthesis Inhibitors; Recombinant Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae

2009
Completing the hypusine pathway in Plasmodium.
    The FEBS journal, 2009, Volume: 276, Issue:20

    Topics: Amino Acid Sequence; Animals; Blotting, Western; Gas Chromatography-Mass Spectrometry; Lysine; Mixed Function Oxygenases; Molecular Sequence Data; Molecular Structure; Plasmodium; Polymerase Chain Reaction; Protozoan Proteins; Sequence Homology, Amino Acid

2009
Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.
    Retrovirology, 2009, Oct-13, Volume: 6

    Topics: Anti-HIV Agents; Ciclopirox; Deferiprone; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Gene Expression; HIV-1; Humans; Leukocytes, Mononuclear; Lysine; Mixed Function Oxygenases; Peptide Initiation Factors; Pyridones; RNA-Binding Proteins; Virus Replication

2009
eIF5A promotes translation elongation, polysome disassembly and stress granule assembly.
    PloS one, 2010, Apr-01, Volume: 5, Issue:4

    Topics: Arsenites; Cell Line, Tumor; Cytoplasmic Granules; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Peptide Initiation Factors; Polyribosomes; Protein Biosynthesis; RNA-Binding Proteins; RNA, Small Interfering; Stress, Physiological

2010
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:6

    Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Islets of Langerhans; Lysine; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Peptide Initiation Factors; RNA-Binding Proteins

2010
PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica.
    Molecular cell, 2010, Jul-30, Volume: 39, Issue:2

    Topics: Animals; Bacterial Proteins; Drug Resistance, Microbial; Female; Gene Expression Regulation, Bacterial; Genomic Islands; Lysine; Lysine-tRNA Ligase; Mice; Peptide Elongation Factors; Protein Processing, Post-Translational; Salmonella enterica; Virulence Factors

2010
Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).
    The Biochemical journal, 2011, Jan-01, Volume: 433, Issue:1

    Topics: Acetylation; Acetyltransferases; Animals; Cattle; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; Protein Binding; RNA-Binding Proteins

2011
Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.
    Protein engineering, design & selection : PEDS, 2011, Volume: 24, Issue:3

    Topics: Animals; Cattle; Cloning, Molecular; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Genetic Vectors; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Recombinant Proteins; RNA-Binding Proteins; Temperature; Time Factors

2011
A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different diseases.
    Amino acids, 2012, Volume: 42, Issue:5

    Topics: Animals; Antimalarials; Catalytic Domain; Chromatography, High Pressure Liquid; Eukaryotic Initiation Factor-5; Humans; Lysine; Malaria; Mice; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Plasmodium; Protein Hydrolysates

2012
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
    Amino acids, 2012, Volume: 42, Issue:2-3

    Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Methylation; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine

2012
Proteomic profiling of germ cell cancer cells treated with aaptamine, a marine alkaloid with antiproliferative activity.
    Journal of proteome research, 2012, Apr-06, Volume: 11, Issue:4

    Topics: Amino Acid Sequence; Antineoplastic Agents; Biological Products; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; HEK293 Cells; Humans; Lysine; Molecular Sequence Data; Naphthyridines; Neoplasms, Germ Cell and Embryonal; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Proteins; Proteome; Proteomics; Reproducibility of Results; RNA-Binding Proteins

2012
A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA, Protozoan; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Genes, Protozoan; Humans; In Vitro Techniques; Leishmania donovani; Lysine; Metabolic Networks and Pathways; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Insertional; Peptide Initiation Factors; Phylogeny; Protozoan Proteins; Recombinant Proteins; RNA-Binding Proteins; Sequence Homology, Amino Acid; Species Specificity

2012
A tumour suppressor network relying on the polyamine-hypusine axis.
    Nature, 2012, Jul-12, Volume: 487, Issue:7406

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Female; Gene Deletion; Gene Regulatory Networks; Genetic Testing; Humans; Lymphoma, B-Cell; Lysine; Mice; Mice, Inbred C57BL; Polyamines; Reproducibility of Results; RNA, Small Interfering; Tumor Suppressor Proteins

2012
Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A).
    FEBS letters, 2012, Sep-21, Volume: 586, Issue:19

    Topics: Acetylation; Active Transport, Cell Nucleus; Eukaryotic Translation Initiation Factor 5A; Gene Knockdown Techniques; HEK293 Cells; HeLa Cells; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Lysine; p300-CBP Transcription Factors; Peptide Initiation Factors; Recombinant Proteins; RNA-Binding Proteins; RNA, Small Interfering; Sirtuin 2; Subcellular Fractions

2012
Protein-protein-interaction network organization of the hypusine modification system.
    Molecular & cellular proteomics : MCP, 2012, Volume: 11, Issue:11

    Topics: Animals; Computational Biology; DNA-Binding Proteins; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mass Spectrometry; Mice; Mixed Function Oxygenases; Multivesicular Bodies; NIH 3T3 Cells; Nuclear Proteins; Nucleophosmin; Oxidoreductases Acting on CH-NH Group Donors; Peptide Fragments; Peptide Initiation Factors; Protein Interaction Maps; Protein Processing, Post-Translational; Protein Transport; Recombinant Fusion Proteins; Reproducibility of Results; Ribosomal Proteins; RNA-Binding Proteins; Subcellular Fractions

2012
Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Dacarbazine; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Lysine; Male; Mixed Function Oxygenases; Molecular Targeted Therapy; Neoplasm Grading; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Temozolomide

2012
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
    The Journal of biological chemistry, 2013, May-24, Volume: 288, Issue:21

    Topics: Animals; Cattle; Escherichia coli; Gene Knockdown Techniques; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Protozoan Proteins; Recombinant Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, Bovine

2013
The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Cell Wall; Epistasis, Genetic; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation, Fungal; GTP-Binding Proteins; Lysine; Mutation, Missense; Oxidoreductases Acting on CH-NH Group Donors; Peptide Chain Elongation, Translational; Peptide Initiation Factors; Polyribosomes; Protein Binding; Protein Kinase C; Ribosome Subunits, Small, Eukaryotic; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Deletion

2013
A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
    Disease models & mechanisms, 2014, Volume: 7, Issue:8

    Topics: 3T3 Cells; Alleles; Animals; Caenorhabditis elegans; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Senescence; Disease Models, Animal; Embryo Loss; Embryonic Development; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Gene Knockout Techniques; Hydroxylation; Lysine; Mice; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Phenotype; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; ras Proteins; RNA-Binding Proteins

2014
Cryptosporidium parvum has an active hypusine biosynthesis pathway.
    Molecular and biochemical parasitology, 2014, Volume: 195, Issue:1

    Topics: Biosynthetic Pathways; Cryptosporidiosis; Cryptosporidium parvum; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Phylogeny; Protozoan Proteins

2014
The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
    Amino acids, 2014, Volume: 46, Issue:12

    Topics: Autophagy; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Fibrosarcoma; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine

2014
A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.
    Cancer research, 2014, Nov-15, Volume: 74, Issue:22

    Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Ciclopirox; Deoxycytidine; Eukaryotic Translation Initiation Factor 5A; Female; Gemcitabine; Humans; Lysine; Mice; Pancreatic Neoplasms; Peptide Initiation Factors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyridones; ras Proteins; RNA-Binding Proteins

2014
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
    ACS chemical biology, 2015, Jun-19, Volume: 10, Issue:6

    Topics: Biological Transport; Cell Line, Tumor; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Male; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine; Stereoisomerism; Substrate Specificity

2015
Development of orthogonally protected hypusine for solid-phase peptide synthesis.
    The Journal of organic chemistry, 2015, Apr-03, Volume: 80, Issue:7

    Topics: Amino Acid Sequence; Amino Acids; Indicators and Reagents; Lysine; Molecular Structure; Peptides; Pyrrolidinones; Solid-Phase Synthesis Techniques

2015
Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.
    Structure (London, England : 1993), 2015, May-05, Volume: 23, Issue:5

    Topics: Catalytic Domain; Crystallography, X-Ray; Enzyme Stability; Eukaryotic Translation Initiation Factor 5A; Glycerol; Humans; Lysine; Mixed Function Oxygenases; Models, Molecular; Molecular Docking Simulation; Peptide Initiation Factors; RNA-Binding Proteins; Substrate Specificity

2015
Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
    The Journal of biological chemistry, 2015, Jul-24, Volume: 290, Issue:30

    Topics: Animals; Homeostasis; Humans; Lysine; Mice; Mice, Knockout; Mixed Function Oxygenases; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Biosynthesis; Protein Interaction Maps; Protein Processing, Post-Translational

2015
Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.
    Molecular and cellular endocrinology, 2015, Sep-15, Volume: 413

    Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation; Luteinizing Hormone; Lysine; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Ovary; Peptide Initiation Factors; Phosphotransferases (Alcohol Group Acceptor); Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, LH; RNA-Binding Proteins; RNA, Messenger

2015
Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies.
    Journal of molecular biology, 2016, Feb-13, Volume: 428, Issue:3

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Affinity; Crystallography, X-Ray; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; RNA-Binding Proteins

2016
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
    Oncogene, 2016, 10-06, Volume: 35, Issue:40

    Topics: Adult; Aged; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diamines; Disease Progression; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Expression Regulation, Neoplastic; Humans; Lysine; Male; Mice; Middle Aged; Neoplasm Metastasis; Oxidoreductases Acting on CH-NH Group Donors; rhoA GTP-Binding Protein; Signal Transduction

2016
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
    Nature communications, 2016, Apr-18, Volume: 7

    Topics: Animals; Cell Line; Cells, Cultured; Cord Factors; Cytokines; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Granuloma; Immunoblotting; Inflammation; Lectins, C-Type; Lysine; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium tuberculosis; NIH 3T3 Cells; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Protein Biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Toll-Like Receptors

2016
Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence.
    Scientific reports, 2016, Apr-21, Volume: 6

    Topics: Eukaryotic Translation Initiation Factor 5A; Fusarium; Gene Expression; Genes, Fungal; Lysine; Microbial Viability; Mutation; Mycotoxins; Peptide Initiation Factors; Plant Diseases; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA-Binding Proteins; Stress, Physiological; Triticum; Virulence

2016
Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Cell Proliferation; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Lysine; Mutation; Peptide Elongation Factor 2; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Ribosomes; RNA-Binding Proteins; Up-Regulation

2016
Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.
    Nature communications, 2016, 06-16, Volume: 7

    Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Genetic Vectors; Humans; Karyopherins; Kinetics; Lysine; Molecular Docking Simulation; Peptide Initiation Factors; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; ran GTP-Binding Protein; Recombinant Proteins; RNA-Binding Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thermodynamics

2016
Alternative Start Codon Connects eIF5A to Mitochondria.
    Journal of cellular physiology, 2016, Volume: 231, Issue:12

    Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Codon, Initiator; Computer Simulation; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Lysine; Mitochondria; Peptide Initiation Factors; Protein Biosynthesis; Protein Isoforms; Protein Processing, Post-Translational; RNA-Binding Proteins

2016
Hypusination of eIF5A as a Target for Antiviral Therapy.
    DNA and cell biology, 2017, Volume: 36, Issue:3

    Topics: Animals; Antiviral Agents; Drug Delivery Systems; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Signal Transduction; Virus Diseases; Virus Replication

2017
Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis.
    Nucleic acids research, 2017, Aug-21, Volume: 45, Issue:14

    Topics: Amino Acids; Base Sequence; Eukaryotic Translation Initiation Factor 5A; Lysine; Nucleic Acid Conformation; Peptide Biosynthesis; Peptide Initiation Factors; Peptides; Polyamines; Proline; Ribosomes; RNA-Binding Proteins; RNA, Transfer, Phe; RNA, Transfer, Pro; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

2017
KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop.
    Cancer research, 2018, 03-15, Volume: 78, Issue:6

    Topics: Animals; Carcinoma, Pancreatic Ductal; Eukaryotic Translation Initiation Factor 5A; Feedback, Physiological; Female; Glutamine; GTP Phosphohydrolases; Humans; Lysine; Membrane Proteins; Mice, Nude; Pancreatic Neoplasms; Peptide Initiation Factors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); RNA-Binding Proteins; Signal Transduction; Xenograft Model Antitumor Assays

2018
Modification of translation factor aIF5A from Sulfolobus solfataricus.
    Extremophiles : life under extreme conditions, 2018, Volume: 22, Issue:5

    Topics: Archaeal Proteins; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Sulfolobus solfataricus

2018
Insulin action on protein synthesis and its association with eIF5A expression and hypusination.
    Molecular biology reports, 2019, Volume: 46, Issue:1

    Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Eukaryotic Translation Initiation Factor 5A; Insulin; Lysine; Myoblasts; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; Rats; RNA-Binding Proteins; Signal Transduction

2019
Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
    American journal of human genetics, 2019, 02-07, Volume: 104, Issue:2

    Topics: Alleles; Amino Acid Sequence; Child; Child, Preschool; Developmental Disabilities; Eukaryotic Translation Initiation Factor 5A; Female; Genes, Recessive; Haplotypes; Humans; Lysine; Male; Metabolism, Inborn Errors; Mutation; Neurodevelopmental Disorders; Oxidoreductases Acting on CH-NH Group Donors; Pedigree; Peptide Initiation Factors; RNA-Binding Proteins; Seizures; Young Adult

2019
Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne.
    PloS one, 2019, Volume: 14, Issue:7

    Topics: Animals; Biliverdine; Biomarkers; Chromatography, Liquid; Creatine; Genotype; Longitudinal Studies; Lysine; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Prednisolone; Principal Component Analysis

2019
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
    Science signaling, 2019, 12-03, Volume: 12, Issue:610

    Topics: Aged; Alleles; Animals; Cell Proliferation; Crosses, Genetic; Cyclin D2; Diabetes Mellitus, Experimental; Diet, High-Fat; Eukaryotic Translation Initiation Factor 5A; Female; Gene Deletion; Glucose; Homeostasis; Humans; Insulin-Secreting Cells; Lysine; Male; Mice; Mice, Inbred C57BL; Middle Aged; Ornithine Decarboxylase; Peptide Initiation Factors; Polyamines; Protein Kinase C; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins; RNA, Messenger

2019
Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
    PloS one, 2020, Volume: 15, Issue:3

    Topics: Adult; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Eukaryotic Translation Initiation Factor 5A; Female; Humans; Insulin-Secreting Cells; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Middle Aged; Pancreas; Pancreatic Polypeptide-Secreting Cells; Peptide Initiation Factors; RNA-Binding Proteins; Spleen; Young Adult

2020
Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase.
    Biomolecules, 2020, 03-30, Volume: 10, Issue:4

    Topics: Humans; Lysine; Models, Molecular; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Protein Conformation

2020
Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes.
    International journal of molecular sciences, 2020, Jun-27, Volume: 21, Issue:13

    Topics: Apoptosis; Cell Proliferation; Colonic Neoplasms; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation, Neoplastic; Humans; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; Ribosomes; RNA-Binding Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2020
Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021, Volume: 41, Issue:5

    Topics: Animals; Behavior, Animal; Cognition; Eukaryotic Translation Initiation Factor 5A; Guanine; Injections, Intraperitoneal; Ischemic Attack, Transient; Lysine; Male; Mice; Mice, Inbred C57BL; Mitochondria; Models, Animal; Neuroprotection; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Reactive Oxygen Species; RNA-Binding Proteins; Stroke

2021
Flexible NAD
    International journal of molecular sciences, 2020, Jul-31, Volume: 21, Issue:15

    Topics: Binding Sites; Crystallography, X-Ray; Eukaryota; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spermidine

2020
De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells.
    European journal of immunology, 2021, Volume: 51, Issue:1

    Topics: Animals; Cells, Cultured; Eukaryotic Translation Initiation Factor 5A; Female; Glycolysis; Killer Cells, Natural; Lysine; Male; Mice; Mice, Inbred C57BL; Oxidative Phosphorylation; Peptide Initiation Factors; Polyamines; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins; Sterol Regulatory Element Binding Proteins

2021
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.
    Cell death & disease, 2020, 12-10, Volume: 11, Issue:12

    Topics: Adenomatous Polyposis Coli; Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lysine; Mice, Nude; Open Reading Frames; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Peptides; Polyamines; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins

2020
Hypusination Orchestrates the Antimicrobial Response of Macrophages.
    Cell reports, 2020, 12-15, Volume: 33, Issue:11

    Topics: Animals; Anti-Infective Agents; Disease Models, Animal; Humans; Lysine; Macrophages; Mice

2020
Yeast Translation Elongation Factor eIF5A Expression Is Regulated by Nutrient Availability through Different Signalling Pathways.
    International journal of molecular sciences, 2020, Dec-28, Volume: 22, Issue:1

    Topics: Aerobiosis; Carbon; Citric Acid Cycle; Down-Regulation; Eukaryotic Translation Initiation Factor 5A; Fermentation; Gene Expression Regulation, Fungal; Glucose; Heme; Iron; Iron Deficiencies; Lysine; Mechanistic Target of Rapamycin Complex 1; Metabolic Flux Analysis; Models, Biological; Nutrients; Peptide Initiation Factors; Protein Isoforms; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Up-Regulation

2020
Alternative human eIF5A protein isoform plays a critical role in mitochondria.
    Journal of cellular biochemistry, 2021, Volume: 122, Issue:5

    Topics: Apoptosis; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Microscopy, Electron, Transmission; Mitochondria; Peptide Initiation Factors; Protein Isoforms; RNA-Binding Proteins

2021
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
    Nature communications, 2021, 02-05, Volume: 12, Issue:1

    Topics: Adolescent; Amino Acid Sequence; Animals; Child; Developmental Disabilities; Embryo, Nonmammalian; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Developmental; Humans; Lysine; Male; Microcephaly; Micrognathism; Peptide Initiation Factors; Peptides; Protein Biosynthesis; Protein Conformation; Protein Isoforms; Ribosomes; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spermidine; Zebrafish; Zebrafish Proteins

2021
Eukaryotic translation initiation factor 5A and its posttranslational modifications play an important role in proliferation and potentially in differentiation of the human enteric protozoan parasite Entamoeba histolytica.
    PLoS pathogens, 2021, Volume: 17, Issue:2

    Topics: Cell Differentiation; Cell Proliferation; Entamoeba histolytica; Entamoebiasis; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins

2021
Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:5

    Topics: Animals; Cell Proliferation; Eukaryotic Translation Initiation Factor 5A; Female; Lysine; Male; Mice; Mice, Knockout; Organogenesis; Oxidoreductases Acting on CH-NH Group Donors; Pancreas, Exocrine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins

2021
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
    Cell reports, 2021, 04-13, Volume: 35, Issue:2

    Topics: Administration, Oral; Aging, Premature; Animals; Brain; Cell Respiration; Drosophila melanogaster; Drosophila Proteins; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Locomotion; Lysine; Memory; Mitochondria; Mitochondrial Proteins; Models, Animal; Neurons; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine

2021
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
    Cell, 2021, 08-05, Volume: 184, Issue:16

    Topics: Animals; Cell Differentiation; Cell Lineage; Cell Polarity; Cell Proliferation; Chromatin; Citric Acid Cycle; Colitis; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Epigenome; Histones; Inflammation; Lymphocyte Subsets; Lysine; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Polyamines; T-Lymphocytes, Helper-Inducer; Th17 Cells; Transcription Factors

2021
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
    The Journal of biological chemistry, 2021, Volume: 297, Issue:5

    Topics: Animals; Cerebellar Cortex; Cognition; Eukaryotic Translation Initiation Factor 5A; Hippocampus; Humans; Lysine; Mice; Mice, Knockout; Mixed Function Oxygenases; Neurogenesis; Neurons; Organ Specificity; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins

2021
Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder.
    American journal of human genetics, 2022, 08-04, Volume: 109, Issue:8

    Topics: Alleles; Gene Expression; Humans; Lysine; Mixed Function Oxygenases; Neurodevelopmental Disorders

2022
The first evidence of biological activity for free Hypusine, an enigmatic amino acid discovered in the '70s.
    Amino acids, 2023, Volume: 55, Issue:7

    Topics: Amino Acids; Animals; Cattle; Eukaryotic Translation Initiation Factor 5A; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Rats; Temozolomide

2023