hypusine has been researched along with lysine in 185 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (16.76) | 18.7374 |
| 1990's | 48 (25.95) | 18.2507 |
| 2000's | 37 (20.00) | 29.6817 |
| 2010's | 48 (25.95) | 24.3611 |
| 2020's | 21 (11.35) | 2.80 |
| Authors | Studies |
|---|---|
| Byers, TL; Ganem, B; Pegg, AE | 1 |
| Bartig, D; Klink, F | 1 |
| Bartig, D; Frank, J; Klink, F; Lemkemeier, K; Lottspeich, F | 1 |
| Chamot, D; Kuhlemeier, C | 1 |
| Kinzy, TG; Merrick, WC; Park, MH; Wolff, EC | 1 |
| Folk, JE; Hershey, JW; Park, MH; Smit-McBride, Z; Wolff, EC | 1 |
| Kakimoto, Y; Kotani, K; Sano, A; Ueno, S | 1 |
| Chung, SI; Folk, JE; Lewis, MS; Park, MH | 1 |
| Hershey, JW; Kang, HA; Schnier, J; Schwelberger, HG; Smit-McBride, Z | 1 |
| Abbruzzese, A; Beninati, S; Folk, JE | 1 |
| Autuori, F; Farrace, MG; Imparato, M; Piacentini, M; Piredda, L | 1 |
| Hershey, JW; Schnier, J; Smit-McBride, Z | 1 |
| Chen, KY; Dou, QP | 3 |
| Chen, KY; Davis, RH; Seyfzadeh, M; Yang, YC | 1 |
| Dever, TE; Hershey, JW; Merrick, WC; Smit-McBride, Z | 1 |
| Hershey, JW; Kaufman, RJ; Schnier, J; Smit-McBride, Z | 1 |
| Park, MH | 4 |
| Centea-Intemann, M; Lottspeich, F; Noegel, AA; Sandholzer, U | 1 |
| Chang, ZF; Chen, KY | 1 |
| Abbruzzese, A; Folk, JE; Park, MH | 2 |
| Duncan, RF; Hershey, JW | 1 |
| Folk, JE; Park, MH | 1 |
| Liu, TY; Neece, SH; Park, MH; Swiggard, WJ | 1 |
| Bernhardt, A; Gerner, EW; Mamont, PS; Siat, M | 1 |
| Chused, TM; Coligan, J; Cooper, HL; Lal, RB | 1 |
| Gallop, PM; Paz, MA; Torrelio, BM | 3 |
| Gerner, EW; Murphey, RJ | 1 |
| Gordon, ED; Lee, C; Lindquist, SL; Meredith, SC; Mora, R | 1 |
| Gordon, ED; Lindquist, SL; Meredith, SC; Mora, R | 1 |
| Abbruzzese, A; Folk, JE; Park, MH; Wolff, EC | 1 |
| Gerner, EW; Murphey, RJ; Tome, ME | 1 |
| Tabor, CW; Tabor, H | 1 |
| Braverman, R; Cooper, HL; Folk, JE; Park, MH; Safer, B | 1 |
| Chung, SI; Cooper, HL; Folk, JE; Park, MH | 1 |
| Kakimoto, Y; Miyake, M; Sano, A | 1 |
| Folk, JE; Liberato, DJ; Park, MH; Yergey, AL | 1 |
| Cooper, HL; Folk, JE; Park, MH | 2 |
| Auer, M; Csonga, R; Eckerskorn, C; Eder, J; Joäo, HC; Klier, H; Lottspeich, F | 1 |
| Auer, M; Csonga, R; Eder, J; João, HC; Klier, H; Koettnitz, K | 1 |
| Klier, H; Lottspeich, F; Wöhl, T | 1 |
| Chung, SI; Folk, JE; Kang, KR; Park, MH; Wolff, EC | 1 |
| Folk, JE; Lee, YB; Park, MH | 1 |
| Hanauske, AR; Hanauske-Abel, HM; McCaffrey, T; Slowinska, B; Staiano-Coico, L; Szabo, P; Wilson, RC; Zagulska, S | 1 |
| Abbruzzese, A; Beninati, S; Jakus, J; Nicolini, L; Passeggio, A | 1 |
| Joe, YA; Park, MH; Rinaudo, MS | 1 |
| Folk, JE; Lee, YB; Park, MH; Wolff, EC | 1 |
| Hauber, J; Hirt, H; Klier, H; Klink, F; Lottspeich, F; Magdolen, V; Wöhl, T | 1 |
| Baumruker, T; Bevec, D; Hauber, J; Holter, W; Klier, H; Lottspeich, F; Tschachler, E; Valent, P | 1 |
| Byers, TL; Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Folk, JE; Park, MH; Wolff, EC | 2 |
| Folk, JE; Hanauske, AR; Hanauske-Abel, HM; Lalande, M; Park, MH; Popowicz, AM | 1 |
| Eckerskorn, C; Klier, H; Lottspeich, F; Magdolen, V; Wöhl, T | 1 |
| Ammer, H; Klier, H; Lottspeich, F; Magdolen, V; Wöhl, T | 1 |
| Hershey, JW; Kang, HA; Schwelberger, HG | 2 |
| Auer, M; Csonga, R; Eckerskorn, C; Eder, J; Ettmayer, P; Klier, H | 1 |
| Abid, MR; Miyazaki, M; Sasaki, K | 1 |
| Beppu, T; Samejima, K; Shirahata, A | 1 |
| Gerner, EW; Tome, ME | 1 |
| Chen, KY; Chen, ZP | 2 |
| Abbruzzese, A; Beninati, S; Bianco, AR; Caraglia, M; Improta, S; Leardi, A; Nicolini, L; Passeggio, A; Pinto, A; Tagliaferri, P | 1 |
| Fiser, SM; Gerner, EW; Payne, CM; Tome, ME | 1 |
| Andrus, L; Grady, RW; Hanauske, AR; Hanauske-Abel, HM; Huima-Byron, T; Slowinska, B; Szabo, P; Zagulska, S | 1 |
| Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO | 2 |
| Abbruzzese, A; Beninati, S; Caraglia, M; Gentile, V; Lentini, A; Tagliaferri, P | 1 |
| Park, MH; Wolff, EC | 2 |
| Kwa, MS; Thomas, AA; van Marwijk, M; van Oers, MM; Vlak, JM | 1 |
| Jansson, BP; Johansson, HE; Malandrin, L | 1 |
| Abbruzzese, A; Budillon, A; Caraglia, M; Tagliaferri, P | 1 |
| Bevec, D; Hauber, J; Krätzer, F; Kruse, M; Kuhnt, C; Rosorius, O; Schuler, G; Steinkasserer, A | 1 |
| Bischoff, FR; Görlich, D; Hartmann, E; Kostka, S; Kraft, R; Kutay, U; Lipowsky, G; Schwarzmaier, P | 1 |
| Chen, KY; Xu, A | 1 |
| Lee, CH; Park, MH | 1 |
| Abbruzzese, A; Beninati, S; Budillon, A; Caraglia, M; D'Alessandro, AM; del Prete, S; Giuberti, G; Lentini, A; Marra, M | 1 |
| Albrecht, BK; DeMong, DE; Jain, RP; Williams, RM | 1 |
| Beppu, T; Fukuchi-Shimogori, T; Igarashi, K; Kashiwagi, K; Nishimura, K; Ohki, Y; Saiga, K; Sakata, K; Shirahata, A | 1 |
| Jao, DL; Yu Chen, K | 1 |
| Joe, YA; Kim, HK; Lee, Y; Park, HE; Park, MH | 1 |
| Kikukawa, S; Kimura, M; Ohsawa, A; Tanaka, I; Yao, M | 1 |
| Abbruzzese, A; Baldi, A; Caraglia, M; D'Alessandro, AM; Giuberti, G; Marra, M; Tagliaferri, P; Tassone, P; Venuta, S | 1 |
| He, K; Hu, MR; Jin, BF; Lan, Y; Shen, BF; Wang, HX; Wang, J; Wei, KH; Yang, SC; Zhang, XM; Zhou, T | 1 |
| He, K; Hu, MR; Jin, BF; Shen, BF; Yu, M; Zhang, XM | 1 |
| Chattopadhyay, MK; Tabor, CW; Tabor, H | 1 |
| Igarashi, K; Kashiwagi, K; Murozumi, K; Nishimura, K; Park, MH; Shirahata, A | 1 |
| Bevec, D; Choidas, A; Harrer, T; Hauber, I; Hauber, J; Heukeshoven, J; Horn, F; Krätzer, F | 1 |
| Chen, KY; Jao, DL | 1 |
| Clement, PM; Johansson, HE; Park, MH; Wolff, EC | 1 |
| Gregio, AP; Komili, S; Lustri, WR; Maragno, AL; Mestriner, CA; Pandolfi, JR; Valentini, SR; Zanelli, CF | 1 |
| Balabanov, S; Bokemeyer, C; Brassat, U; Brümmendorf, TH; Copland, M; Gontarewicz, A; Hartmann, U; Hauber, I; Hauber, J; Holyoake, TL; Kammer, W; Kanz, L; Nordheim, A; Priemer, M; Schwarz, G; Wilhelm, T; Ziegler, P | 1 |
| Goebel, T; Hoerauf, A; Holzgrabe, U; Kaiser, A; Saeftel, M; Ulmer, D | 1 |
| Hester, L; Higginson, DS; Huang, Y; Park, MH; Snyder, SH | 1 |
| Klug, G; Wagner, S | 1 |
| Kang, KR; Kim, YS; Park, MH; Wolff, EC | 1 |
| Abbruzzese, A; Agostinelli, E; Budillon, A; Caraglia, M; Giuberti, G; Lombardi, A; Marra, M; Meo, G; Tempera, G | 1 |
| Alhonen, L; Cerrada-Gimenez, M; Grigorenko, N; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J | 1 |
| Cano, VS; Henderson, CA; Hershey, JW; Jeon, GA; Johansson, HE; Park, JH; Park, MH; Valentini, SR | 1 |
| Chattopadhyay, MK; Park, MH; Tabor, H | 1 |
| Baptista, IL; Cambiaghi, TD; Costa-Neto, CM; Curi, R; Hirabara, SM; Lambertucci, RH; Luchessi, AD; Moriscot, AS; Silveira, LR | 1 |
| Blatch, GL; Dorrington, RA; Gentz, PM | 1 |
| Do, JW; Hong, GE; Kim, KK; Kim, WJ; Kim, YO; Kong, HJ; Lee, CH; Lee, JH; Lee, SJ; Nam, BH | 1 |
| Kaevel, J; Lee, SB; Park, JH; Park, MH; Sramkova, M; Weigert, R | 1 |
| Dever, TE; Eyler, DE; Green, R; Saini, P | 1 |
| Atemnkeng, V; Blavid, R; Frommholz, D; Kaiser, AE; Kusch, P; Marciniak, J; Marcus, K; Scheer, H; Tu, JM; Zhao, KH | 1 |
| D'Alliessi Gandolfi, D; Hanauske-Abel, HM; Hoque, M; Mathews, MB; Palumbo, P; Park, MH; Pe'ery, T; Saxena, D | 1 |
| Nishimura, K; Park, MH; Valentini, SR; Zanelli, CF | 1 |
| Anderson, P; Ivanov, P; Li, CH; Ohn, T; Tisdale, S | 1 |
| Chakrabarti, SK; Dinarello, CA; Dondero, RS; Lewis, EC; Maier, B; Mirmira, RG; Nadler, JL; Nunemaker, CS; Ogihara, T; Robbins, RD; Stull, ND; Taylor, CA; Tersey, SA; Thompson, JE; Trace, AP | 1 |
| Maier, B; Mirmira, RG; Tersey, SA | 1 |
| Edvokimova, E; Fang, FC; Ibba, M; Kumar, R; Navarre, WW; Prost, LR; Roy, H; Savchenko, A; Singer, A; Xie, JL; Zou, SB | 1 |
| Deck, JA; Folk, JE; Fraser, CS; Lee, SB; Park, JH; Park, MH; Pegg, AE; Sokabe, M | 1 |
| Dias, CA; Fraser, CS; Lee, SB; Park, JH; Park, MH; Sokabe, M; Valentini, SR | 1 |
| Agostinelli, E; Kaiser, A; Khomutov, AR; Simonian, A | 1 |
| Altmann, M; Bütikofer, P; Greganova, E | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Park, JH; Park, MH; Simonian, A; Vepsäläinen, J | 1 |
| Abbruzzese, A; Caraglia, M; Marra, M; Park, MH; Wolff, EC | 1 |
| Balabanov, S; Bokemeyer, C; Dyshlovoy, SA; Fedorov, SN; Gesell Salazar, M; Hauber, J; Honecker, F; Jacobsen, C; Krepstakies, M; Naeth, I; Preukschas, M; Priyadarshini, P; Scharf, C; Shubina, LK; Sievert, H; Stonik, VA; Venz, S; Walther, R | 1 |
| Chawla, B; Kumar, RR; Madhubala, R; Park, MH; Srinivasan, N; Subramanian, G; Tyagi, N | 1 |
| Appelmann, I; Krasnitz, A; Lindqvist, L; Lowe, SW; Miething, C; Pappin, D; Pelletier, J; Reyes, J; Ruse, C; Scuoppo, C; Teruya-Feldstein, J; Yoon, S | 1 |
| Ishfaq, M; Ito, A; Maeda, S; Maeta, K; Natsume, T; Yoshida, M | 1 |
| Balabanov, S; Bokemeyer, C; Braig, M; Brümmendorf, TH; Dhople, VM; Duncan, KE; Hauber, J; Nagel, CH; Pällmann, N; Platas-Barradas, O; Pörtner, R; Preukschas, M; Schaletzky, M; Sievert, H; Venz, S; Walther, R | 1 |
| Balabanov, S; Bokemeyer, C; Braig, M; Hagel, C; Hauber, J; Lamszus, K; Pällmann, N; Preukschas, M; Schulte, A; Sievert, H; Weber, K | 1 |
| Fairlamb, AH; Jones, DC; Nguyen, S; Phillips, MA; Wyllie, S | 1 |
| Galvão, FC; Rossi, D; Silveira, Wda S; Valentini, SR; Zanelli, CF | 1 |
| de Almeida, OP; Galvão, FC; Medeiros, AI; Rossetto, Dde B; Rossi, D; Toledo, TR; Valentini, SR; Watanabe, TF; Zanelli, CF | 1 |
| Balabanov, S; Boettcher, S; Bokemeyer, C; Braig, M; Brümmendorf, TH; Duncan, KE; Hauber, J; Hengartner, MO; Hermans-Borgmeyer, I; Janiesch, PC; Manz, MG; Miller, KK; Pällmann, N; Preukschas, M; Schweizer, M; Sendoel, A; Sievert, H; Streichert, T; Venz, S; Walther, R | 1 |
| Gowri, VS; Madhubala, R; Mandal, S; Mittal, N; Morada, M; Park, MH; Quirch, A; Tripathi, P; Yarlett, N | 1 |
| Corazzari, M; Ippolito, G; Oliverio, S; Piacentini, M; Piredda, L; Sestito, C | 1 |
| Bouvet, M; Fujimura, K; Kaushal, S; Kelber, JA; Klemke, RL; Lowy, AM; Metildi, C; Strnadel, J; Wright, T | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Petit, M; Vepsäläinen, J; Weisell, J | 1 |
| Deshayes, K; Fang, G; Pham, V; Song, A; Tan, D; Tom, J; Yu, T; Yu, Z; Zhang, D | 1 |
| Böttger, LH; Han, Z; Hauber, J; Hilgenfeld, R; Klinke, S; Sakai, N; Trautwein, AX | 1 |
| Hershey, JW; Mathews, MB | 1 |
| Balabanov, S; Bokemeyer, C; Braig, M; Hagel, C; Haralambieva, E; Hauber, J; Hermans-Borgmeyer, I; Nagel, CH; Neumann, M; Pällmann, N; Preukschas, M; Schweizer, M; Sievert, H; Wild, P | 1 |
| Gulappa, T; Menon, B; Menon, KM | 1 |
| Carter, PJ; Deshayes, K; Dixit, VM; He, M; Song, A; Zhai, Q | 1 |
| Fujiwara, N; Imoto, S; Inazawa, J; Kawano, T; Kozaki, KI; Miyano, S; Morishita, M; Muramatsu, T; Tsuda, H; Yamaguchi, R | 1 |
| Choi, UY; Choi, WY; Kang, JS; Kim, CH; Kim, YJ; Kim-Ha, J; Lee, WB; Zhang, Q | 1 |
| Chemnitz, J; Hadeler, B; Hauber, J; Kröger, C; Martinez-Rocha, AL; Schäfer, W; Willingmann, P; Woriedh, M | 1 |
| Barbosa, NM; Boldrin, PE; Fraser, CS; Galvão, FC; Hershey, JW; Rossi, D; Valentini, SR; Zanelli, CF | 1 |
| Aksu, M; Görlich, D; Trakhanov, S | 1 |
| Cleveland, JL; Nakanishi, S | 1 |
| Almeida, IC; de Proença, AR; Lourenço, RF; Luchessi, AD; Meneguello, L; Pereira, KD; Tamborlin, L | 1 |
| Connor, JH; Olsen, ME | 1 |
| Dever, TE; Gutierrez, E; Katoh, T; Kim, JR; Shin, BS; Suga, H | 1 |
| Fujimura, K; Klemke, RL; Wang, H; Watson, F | 1 |
| Amici, A; Bassani, F; Benelli, D; Bläsi, U; Cacciamani, T; La Teana, A; Londei, P; Märtens, B; Romagnoli, A | 1 |
| Turpaev, KT | 1 |
| de Proença, ARG; Luchessi, AD; Meneguello, L; Pereira, KD; Tamborlin, L | 1 |
| Au, PB; Chung, WK; Deng, L; Devinsky, O; Ganapathi, M; Hanner, A; Karlowicz, D; LeDuc, CA; Lee, J; Mastracci, TL; McDonald, M; Mirmira, RG; Okur, V; Padgett, LR; Park, MH; Person, R; Shen, Y; Tagoe, J; Wang, J; Willaert, R; Wolf, B; Yamada, K | 1 |
| Boca, SM; Gill, K; Hathout, Y; Hoffman, EP; Li, Z; Nagaraju, K; Ressom, HW; Thangarajh, M; Varghese, RS; Zhang, A | 1 |
| Alonso, LC; Anderson-Baucum, E; Bernal-Mizrachi, E; Garcia-Ocaña, A; Levasseur, EM; Liu, Y; Maier, B; Mastracci, TL; Mirmira, RG; Mosley, AL; Orr, KS; Piñeros, AR; Scott, D; Syed, F; Tersey, SA; Wu, W; Yamada, K | 1 |
| Bekebrede, AF; Boer, VCJ; Gerrits, WJJ; Keijer, J | 1 |
| Colvin, SC; Mastracci, TL; Mirmira, RG; Padgett, LR | 1 |
| Grudnik, P; Wątor, E; Wilk, P | 1 |
| Benelli, D; Catalanotto, C; La Teana, A; Londei, P; Martella, M; Talora, C | 1 |
| Blondeau, N; Bourourou, M; Friard, J; Gouix, E; Heurteaux, C; Melis, N; Tauc, M | 1 |
| Chen, M; Gai, Z; Okada, C; Yao, M; Ye, Y; Yu, J | 1 |
| Assmann, N; Choi, C; Dettmer, K; Finlay, DK; Gardiner, CM; Keane, C; O'Brien, KL; O'Connor, E; Oefner, PJ; Walls, J | 1 |
| Agostinelli, E; Bertani, C; Bordone, R; Canettieri, G; Coni, S; De Smaele, E; Di Magno, L; Di Marcotullio, L; Fatica, A; Giannini, G; Guerrieri, F; Ianniello, Z; Infante, P; Licursi, V; Macone, A; Maroder, M; Moretti, M; Petroni, M; Serrao, SM; Yurtsever, ZN | 1 |
| Allaman, MM; Asim, M; Barry, DP; Calcutt, MW; Delagado, AG; Finley, JL; Gobert, AP; Latour, YL; Mirmira, RG; Piazuelo, MB; Rose, KL; Schey, KL; Sierra, JC; Smith, TM; Verriere, TG; Wilson, KT | 1 |
| Alepuz, P; Barba-Aliaga, M; Corman, A; Martínez-Pastor, MT; Stanciu, A; Villarroel-Vicente, C | 1 |
| Consonni, SR; de Lima, TI; Luchessi, AD; Pereira, KD; Silveira, LR; Tamborlin, L | 1 |
| Amiel, J; Banka, S; Crilly, S; Cross, LA; Cuvertino, S; Davies, SJ; Douglas, AGL; Faundes, V; Fry, AE; Gordon, CT; Granadillo, JL; Harrison, V; Jennings, MD; Kasher, PR; Legraie, S; Lehalle, D; Newkirk, P; Newman, WG; Pavitt, GD; Ranells, J; Saunders, CJ; Splitt, M; Sullivan, BR; Withers, SE | 1 |
| Jeelani, G; Nozaki, T | 1 |
| Anderson-Baucum, EK; Connors, CT; Mastracci, TL; Mirmira, RG; Padgett, LR; Robertson, MA; Wu, W | 1 |
| Beuschel, CB; Bogdanow, B; Conrad, TOF; Huang, S; Kintscher, U; Kollipara, L; Liang, Y; Liu, F; Lützkendorf, J; Madeo, F; Maglione, M; Piao, C; See, JCK; Sickmann, A; Sigrist, SJ; Toppe, D | 1 |
| Baixauli, F; Balabanov, S; Buescher, JM; Corrado, M; Edwards-Hicks, J; Field, CS; Flachsmann, L; Green, DR; Grzes, KM; Haessler, F; Kabat, AM; Kamiński, MM; Kuchroo, VK; Mittler, G; Musa, Y; Pearce, EJ; Pearce, EL; Piletic, K; Puleston, DJ; Sanin, DE; Schimmelpfennig, L; Stanckzak, M; Villa, M; Wang, C; Weiss, HJ; Yosef, N | 1 |
| Banka, S; Chung, WK; Kar, RK; Park, MH; Ziegler, A | 1 |
| Hanner, AS; Kar, RK; Mastracci, TL; Mirmira, RG; Park, MH; Springer, D; Starost, MF | 1 |
| Bézieau, S; Boland, A; Bonneau, D; Chung, WK; Coubes, C; Deleuze, JF; Faivre, L; Hanner, AS; Kar, RK; Küry, S; Le Mao, M; Lenaers, G; Maystadt, I; Navet, B; Park, MH; Prouteau, C; Rauch, A; Steindl, K; Tran Mau-Them, F; Zanoni, P; Ziegler, A | 1 |
| Cruz-Pulido, YE; Mounce, BC | 1 |
| Guimarães, DSPSF; Luchessi, AD; Pereira, KD; Silveira, LR; Tamborlin, L | 1 |
22 review(s) available for hypusine and lysine
| Article | Year |
|---|---|
Biosynthesis of hypusine in eIF-4D precursors.
Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; RNA-Binding Proteins | 1988 |
Hypusine biosynthesis in protein and its biological consequences.
Topics: Animals; Humans; Lysine; Protein Biosynthesis | 1988 |
Polyamines.
Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning, Molecular; DNA; Escherichia coli; Lysine; Mutation; Neoplasms; Neurospora crassa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Physarum; Plants; Polyamines; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Putrescine; RNA; Saccharomyces cerevisiae; Spermidine; Spermidine Synthase; Spermine; Spermine Synthase | 1984 |
Is hypusine essential for eukaryotic cell proliferation?
Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins; Spermidine | 1993 |
Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.
Topics: Amino Acid Sequence; Animals; Cell Physiological Phenomena; Eukaryotic Translation Initiation Factor 5A; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger | 1993 |
The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis.
Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Drug Design; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger | 2001 |
The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A).
Topics: Animals; Catalysis; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Tertiary; RNA-Binding Proteins | 2006 |
Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malaria.
Topics: Animals; Antiparasitic Agents; Drug Design; Humans; Lysine; Malaria; Plasmodium; Polyamines | 2006 |
Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biological Evolution; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Elongation Factors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Alignment; Spermidine; Substrate Specificity | 2007 |
Anticancer drugs and hyperthermia enhance cytotoxicity induced by polyamine enzymatic oxidation products.
Topics: Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Caspases; Cattle; Cell Proliferation; Docetaxel; Drug Synergism; Etoposide; Eukaryotic Translation Initiation Factor 5A; Humans; Hyperthermia, Induced; Interferon-alpha; Lysine; Ornithine Decarboxylase; Oxidation-Reduction; Peptide Initiation Factors; Polyamines; RNA-Binding Proteins; Taxoids | 2007 |
Functional significance of eIF5A and its hypusine modification in eukaryotes.
Topics: Animals; Bacteria; Bacterial Proteins; Eukaryota; Eukaryotic Translation Initiation Factor 5A; Fungal Proteins; Fungi; Humans; Lysine; Peptide Initiation Factors; Protein Structure, Secondary; RNA-Binding Proteins | 2010 |
Hypusine: a new target for therapeutic intervention in diabetic inflammation.
Topics: Animals; Diabetes Complications; Eukaryotic Translation Initiation Factor 5A; Humans; Inflammation; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Transport; RNA-Binding Proteins | 2010 |
Unique modifications of translation elongation factors.
Topics: Animals; Eukaryotic Initiation Factor-5; Histidine; Humans; Lysine; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Phosphatidylethanolamines; Protein Processing, Post-Translational | 2011 |
eIF5A isoforms and cancer: two brothers for two functions?
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Neoplasms; Peptide Initiation Factors; Protein Isoforms; RNA-Binding Proteins | 2013 |
Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: understanding the action of the inhibitor GC7 on a murine macrophage cell line.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Inflammation; Lysine; Macrophages; Mice; Molecular Targeted Therapy; Nitric Oxide; Peptide Initiation Factors; RNA-Binding Proteins | 2014 |
The translation factor eIF5A and human cancer.
Topics: Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Humans; Lysine; Neoplasms; Oncogene Proteins; Peptide Chain Elongation, Translational; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Protein Isoforms; Protein Processing, Post-Translational; RNA-Binding Proteins | 2015 |
Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer.
Topics: Animals; Biogenic Polyamines; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Neoplasm Proteins; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins | 2016 |
Translation Factor eIF5A, Modification with Hypusine and Role in Regulation of Gene Expression. eIF5A as a Target for Pharmacological Interventions.
Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Humans; Lysine; Molecular Targeted Therapy; Peptide Initiation Factors; Protein Biosynthesis; RNA-Binding Proteins | 2018 |
Hypusine, a polyamine-derived amino acid critical for eukaryotic translation.
Topics: Animals; Eukaryota; Humans; Lysine; Polyamines; Protein Biosynthesis | 2018 |
The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine.
Topics: Animals; Colon; Dietary Proteins; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; Polyamines; Protein Biosynthesis; RNA-Binding Proteins; Transcription, Genetic | 2020 |
Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mice; Neurodevelopmental Disorders; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins | 2022 |
Good cop, bad cop: Polyamines play both sides in host immunity and viral replication.
Topics: Adaptive Immunity; Antineoplastic Agents; Antiviral Agents; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Host Microbial Interactions; Humans; Lysine; Polyamines; Protein Processing, Post-Translational; Virus Diseases; Virus Replication; Viruses | 2023 |
163 other study(ies) available for hypusine and lysine
| Article | Year |
|---|---|
Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Deoxyadenosines; Kinetics; Leukemia L1210; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Tumor Cells, Cultured | 1992 |
Determination of the unusual amino acid hypusine at the lower picomole level by derivatization with 4-dimethylaminoazobenzene-4'-sulphonyl chloride and reversed-phase high-performance or medium-pressure liquid chromatography.
Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, High Pressure Liquid; Chromatography, Liquid; Indicators and Reagents; Lysine; Molecular Sequence Data; p-Dimethylaminoazobenzene; Spectrophotometry, Ultraviolet; Sulfolobus acidocaldarius; Trypsin | 1992 |
The archaebacterial hypusine-containing protein. Structural features suggest common ancestry with eukaryotic translation initiation factor 5A.
Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, Ion Exchange; Cloning, Molecular; Cyanogen Bromide; Diazonium Compounds; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Indicators and Reagents; Isoelectric Focusing; Lysine; Molecular Sequence Data; Oligonucleotide Probes; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Alignment; Sulfanilic Acids; Sulfolobus | 1992 |
Differential expression of genes encoding the hypusine-containing translation initiation factor, eIF-5A, in tobacco.
Topics: Amino Acid Sequence; Blotting, Northern; Blotting, Western; Cloning, Molecular; Eukaryotic Initiation Factor-5; Gene Expression; Lysine; Molecular Sequence Data; Nicotiana; Peptide Initiation Factors; Plants, Toxic; Sequence Alignment | 1992 |
Two isoforms of eIF-5A in chick embryo. Isolation, activity, and comparison of sequences of the hypusine-containing proteins.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chick Embryo; Chickens; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Genetic Variation; Humans; Lysine; Male; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Putrescine; Rabbits; RNA-Binding Proteins; Sequence Homology, Nucleic Acid; Spermidine; Tritium | 1992 |
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
Topics: Animals; Cadaverine; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; Eflornithine; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Periodic Acid; Puromycin; RNA-Binding Proteins; Spermidine; Substrate Specificity | 1991 |
Isolation and identification of alpha-(beta-alanyl)hypusine from bovine brain.
Topics: Animals; beta-Alanine; Brain Chemistry; Cattle; Dipeptides; Lysine | 1991 |
Eukaryotic initiation factor 5A: the molecular form of the hypusine-containing protein from human erythrocytes.
Topics: Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Denaturation; RNA-Binding Proteins | 1991 |
Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Cloning, Molecular; Codon; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Genetic Vectors; Humans; Kinetics; Lysine; Mitochondria; Molecular Sequence Data; Oligonucleotide Probes; Peptide Initiation Factors; Phenotype; Plasmids; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid | 1991 |
High-performance liquid chromatographic method for determination of hypusine and deoxyhypusine.
Topics: Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Lysine; Male; Microchemistry; Rats; Rats, Inbred Strains; Regression Analysis; Reproducibility of Results; Spectrometry, Fluorescence | 1990 |
Polyamine-dependent post-translational modification of proteins in differentiating mouse epidermal cells.
Topics: Animals; Cell Differentiation; Epidermal Cells; Keratinocytes; Lysine; Mice; Mice, Inbred BALB C; Polyamines; Protein Processing, Post-Translational; Spermidine | 1990 |
The role of mammalian initiation factor eIF-4D and its hypusine modification in translation.
Topics: Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Kinetics; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; Puromycin; RNA-Binding Proteins; RNA, Transfer, Met | 1990 |
Characterization and reconstitution of a cell free system for NAD(+)-dependent deoxyhypusine formation on the 18 kDa eIF-4D precursor.
Topics: Animals; Cell Line; Cell-Free System; Eukaryotic Translation Initiation Factor 5A; Lysine; Mice; Molecular Weight; NAD; Neuroblastoma; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins | 1990 |
Deoxyhypusine/hypusine formation on a 21,000-dalton cellular protein in a Neurospora crassa mutant in vivo and in vitro.
Topics: Electrophoresis, Polyacrylamide Gel; Fungal Proteins; Isoelectric Focusing; Lysine; Mutation; Neurospora; Neurospora crassa; Polyamines | 1990 |
Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cloning, Molecular; DNA; Eukaryotic Translation Initiation Factor 5A; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Protein Conformation; Rabbits; RNA-Binding Proteins | 1989 |
Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein.
Topics: Arginine; Codon; DNA; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Mutation; Nucleic Acid Hybridization; Peptide Initiation Factors; Plasmids; RNA-Binding Proteins; Structure-Activity Relationship; Transfection | 1989 |
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
Topics: Animals; Cell Line; Cricetinae; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; Putrescine; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship | 1989 |
cDNA and derived amino acid sequence of the hypusine containing protein from Dictyostelium discoideum.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Chromatography, Affinity; Codon; Cyanogen Bromide; Dictyostelium; DNA; DNA Restriction Enzymes; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Immunoassay; Lysine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Nucleic Acid Hybridization; Peptide Fragments; Peptide Initiation Factors; RNA-Binding Proteins; RNA, Messenger; Trypsin | 1989 |
Age dependency of the metabolic conversion of polyamines into amino acids in IMR-90 human embryonic lung diploid fibroblasts.
Topics: Amino Acids; Cell Line; Cell Survival; Diploidy; Eflornithine; Enzyme Induction; Fibroblasts; Humans; Lysine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Processing, Post-Translational; Putrescine | 1986 |
Indirect assays for deoxyhypusine hydroxylase using dual-label ratio changes and oxidative release of radioactivity.
Topics: Carbon Radioisotopes; Isotope Labeling; Lysine; Mixed Function Oxygenases; Oxidation-Reduction; Time Factors; Tritium | 1986 |
Changes in eIF-4D hypusine modification or abundance are not correlated with translational repression in HeLa cells.
Topics: Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Hot Temperature; Humans; Lysine; Peptide Initiation Factors; Protein Biosynthesis; RNA-Binding Proteins; Saline Solution, Hypertonic | 1986 |
Biosynthetic labeling of hypusine in mammalian cells. Carbon-hydrogen bond fissions revealed by dual labeling.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Ovary; Protein Processing, Post-Translational; Tritium | 1986 |
Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.
Topics: Amino Acid Sequence; Erythrocytes; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Weight; Peptide Initiation Factors; Peptide Mapping; RNA-Binding Proteins | 1986 |
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Rats; RNA-Binding Proteins; Spermidine; Spermine | 1986 |
Proteins associated with B lymphocyte hyperactivity in New Zealand black mice.
Topics: Amino Acid Sequence; Animals; Autoimmune Diseases; B-Lymphocytes; Isoelectric Point; Lysine; Mice; Mice, Inbred NZB; Molecular Weight; Protein Biosynthesis | 1987 |
The formation and stability of the hypusine containing protein in Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Lysine; Molecular Weight; Ovary; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Spermine | 1987 |
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Eflornithine; Female; Fibroblasts; Gene Expression Regulation; Lysine; Ovary; Protein Biosynthesis; Protein Processing, Post-Translational; Spermidine | 1987 |
Hypusine formation in protein by a two-step process in cell lysates.
Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Hydrogen-Ion Concentration; Kinetics; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Polyamines; Protein Processing, Post-Translational; Rats; RNA-Binding Proteins | 1987 |
Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.
Topics: Amino Acids; Animals; Cells; Drosophila melanogaster; Escherichia coli; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Peptide Mapping; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine | 1987 |
Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates or specificity of protein synthesis is altered.
Topics: Animals; Drosophila melanogaster; Eukaryotic Translation Initiation Factor 5A; Fluorometry; Hot Temperature; Lysine; Peptide Initiation Factors; Protein Biosynthesis; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae; Spores, Fungal | 1987 |
NAD+ stimulated the spermidine-dependent hypusine formation on the 18 kDa protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.
Topics: Animals; Cell Line; Cytosol; Lysine; Mice; Molecular Weight; NAD; Nerve Tissue Proteins; Neuroblastoma; Putrescine; Spermidine; Tritium | 1988 |
The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Isoelectric Point; Lysine; Ovary; Peptide Initiation Factors; Peptide Mapping; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 1988 |
Isolation and characterization of an 18 kDa hypusine-containing protein from cultured NB-15 mouse neuroblastoma cells.
Topics: Adsorption; Animals; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Lysine; Mice; Molecular Weight; Neoplasm Proteins; Neuroblastoma; Peptide Initiation Factors; Polynucleotides; Rabbits; Reticulocytes; RNA-Binding Proteins; Tumor Cells, Cultured | 1988 |
Post-translational formation of hypusine: biogenesis of translation initiation factor eIF-4D.
Topics: Animals; Eukaryotic Initiation Factor-4F; Gene Expression Regulation; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Putrescine; Spermidine | 1988 |
Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.
Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Humans; Isoelectric Point; Lysine; Mice; Molecular Weight; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins | 1983 |
The mammalian hypusine-containing protein, eukaryotic initiation factor 4D. Structural homology of this protein from several species.
Topics: Animals; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; Electrophoresis, Polyacrylamide Gel; Eukaryotic Translation Initiation Factor 5A; Female; Humans; Lymphocytes; Lysine; Molecular Weight; Ovary; Peptide Fragments; Peptide Initiation Factors; RNA-Binding Proteins; Trypsin | 1984 |
Hydralazine inhibition of the post-translational hydroxylation of deoxyhypusine, a polyamine-derived amino acid.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Replication; Female; Hydralazine; Hydroxylation; Lysine; Ovary; Protein Biosynthesis; Putrescine | 1984 |
A rapid and sensitive method for the determination of hypusine in proteins and its distribution and developmental changes.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Liver; Lysine; Male; Methods; Protein Processing, Post-Translational; Proteins; Rats; Rats, Inbred Strains; Subcellular Fractions; Tissue Distribution | 1984 |
Cellular proliferation and hypusine synthesis.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Culture Media; DNA; Female; Fibroblasts; Humans; Kinetics; Lysine; Ovary; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine | 1984 |
The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.
Topics: Animals; Butylamines; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Mass Spectrometry; Putrescine; Spermidine | 1984 |
Hypusine formation: a unique posttranslational modification in translation initiation factor eIF-4D.
Topics: Animals; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Humans; Lymphocytes; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; Radioisotope Dilution Technique; Reticulocytes; RNA-Binding Proteins; Spermidine; Tritium | 1984 |
Posttranslational formation of hypusine in a single major protein occurs generally in growing cells and is associated with activation of lymphocyte growth.
Topics: Amino Acids; Animals; Cell Division; Cells, Cultured; Cricetinae; Isoelectric Point; Lymphocyte Activation; Lymphocytes; Lysine; Mice; Molecular Weight; Protein Processing, Post-Translational; Proteins | 1982 |
Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.
Topics: Amino Acid Sequence; Chromatography, Gel; Circular Dichroism; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Lysine; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Secondary; RNA-Binding Proteins | 1995 |
The polypeptide chain of eukaryotic initiation factor 5A occurs in two distinct conformations in the absence of the hypusine modification.
Topics: Chromatography, Gel; Circular Dichroism; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Guanidine; Guanidines; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Osmolar Concentration; Peptide Initiation Factors; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; RNA-Binding Proteins | 1995 |
Detection of nonfunctional overexpression gene products using two-dimensional gel electrophoresis with a narrowed pH range.
Topics: Electrophoresis, Gel, Two-Dimensional; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Hydrogen-Ion Concentration; Lysine; Saccharomyces cerevisiae | 1995 |
Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chromosomes, Fungal; DNA, Complementary; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Fungal Proteins; Genes, Fungal; Humans; Lysine; Male; Molecular Sequence Data; Molecular Weight; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polymerase Chain Reaction; Rats; Recombinant Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Testis | 1995 |
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
Topics: Animals; Binding, Competitive; Cell Division; CHO Cells; Cricetinae; Cricetulus; Diamines; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Rats; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship; Testis | 1995 |
Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication.
Topics: Base Sequence; Cell Line; DNA Replication; Electron Transport Complex IV; Eukaryotic Translation Initiation Factor 5A; G1 Phase; Humans; Lymphocytes; Lysine; Methionine Adenosyltransferase; Mimosine; Mixed Function Oxygenases; Molecular Sequence Data; Peptide Initiation Factors; Polyribosomes; RNA-Binding Proteins; RNA, Messenger; S Phase; Sequence Alignment | 1995 |
Identification of a substrate site for transglutaminases on the human protein synthesis initiation factor 5A.
Topics: Animals; Binding Sites; Caseins; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Eukaryotic Translation Initiation Factor 5A; Glutamic Acid; Guinea Pigs; Humans; Kinetics; Liver; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Transglutaminases | 1995 |
Cloning and sequencing of a chick embryo cDNA encoding the 20-kDa hypusine-containing protein, eIF-5A.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Chick Embryo; Cloning, Molecular; DNA, Complementary; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Rabbits; RNA-Binding Proteins | 1993 |
Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.
Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Diamines; Dose-Response Relationship, Drug; Guanine; Indicators and Reagents; Kinetics; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine; Structure-Activity Relationship | 1994 |
The function of the hypusine-containing proteins of yeast and other eukaryotes is well conserved.
Topics: Anaerobiosis; Blotting, Western; Fungal Proteins; Genes, Fungal; Lysine; Mutation; Plasmids; Polymerase Chain Reaction; Protein Biosynthesis; Saccharomyces cerevisiae | 1994 |
Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes.
Topics: Base Sequence; Cell Division; Cell Line; Cells, Cultured; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Gene Expression; HIV Infections; Humans; In Vitro Techniques; Lymphocyte Activation; Lysine; Molecular Sequence Data; Peptide Chain Initiation, Translational; Peptide Initiation Factors; RNA-Binding Proteins; RNA, Messenger; T-Lymphocytes; Time Factors | 1994 |
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Leukemia L1210; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine; Spermine; Substrate Specificity; Tumor Cells, Cultured | 1994 |
Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation.
Topics: Alanine; Amino Acid Sequence; Animals; Cell Division; Cell Line; Cell Line, Transformed; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; G1 Phase; Humans; Lysine; Mimosine; Mixed Function Oxygenases; Molecular Sequence Data; Peptide Initiation Factors; Pyrones; RNA-Binding Proteins; S Phase; Sequence Alignment; Structure-Activity Relationship | 1994 |
Determination and mutational analysis of the phosphorylation site in the hypusine-containing protein Hyp2p.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Fungal Proteins; Lysine; Mass Spectrometry; Molecular Sequence Data; Phosphorylation; Polymerase Chain Reaction; Saccharomyces cerevisiae | 1993 |
The HYP2 gene of Saccharomyces cerevisiae is essential for aerobic growth: characterization of different isoforms of the hypusine-containing protein Hyp2p and analysis of gene disruption mutants.
Topics: Aerobiosis; Anaerobiosis; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Fungal Proteins; Genes, Fungal; Lysine; Mutation; Saccharomyces cerevisiae | 1993 |
Translation initiation factor eIF-5A expressed from either of two yeast genes or from human cDNA. Functional identity under aerobic and anaerobic conditions.
Topics: Aerobiosis; Anaerobiosis; Base Sequence; Conserved Sequence; DNA; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Genes, Fungal; Genetic Variation; Humans; Kinetics; Lysine; Peptide Initiation Factors; Promoter Regions, Genetic; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae | 1993 |
Translation initiation factor eIF-5A, the hypusine-containing protein, is phosphorylated on serine in Saccharomyces cerevisiae.
Topics: Base Sequence; Blotting, Western; DNA, Single-Stranded; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Isoelectric Focusing; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Phosphorylation; Precipitin Tests; Protein Precursors; Puromycin; RNA-Binding Proteins; Saccharomyces cerevisiae; Serine | 1993 |
Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay.
Topics: Chelating Agents; Cobalt; Copper; Eukaryotic Translation Initiation Factor 5A; Ferric Compounds; Ferrous Compounds; HeLa Cells; Humans; Lysine; Manganese; Metals; Mixed Function Oxygenases; Nickel; Oxidation-Reduction; Peptide Initiation Factors; RNA-Binding Proteins; Zinc | 1996 |
Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Base Sequence; Cell Survival; Cloning, Molecular; Eukaryotic Translation Initiation Factor 5A; Fungal Proteins; Genes, Fungal; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Saccharomyces cerevisiae | 1996 |
Determination of covalently bound hypusine and deoxyhypusine to protein using submilligram of protein samples by HPLC.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chromatography, High Pressure Liquid; Lysine; Protein Binding; Rats; Reference Standards; Tumor Cells, Cultured | 1996 |
Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs.
Topics: Animals; Cell Division; Cell Line; Eukaryotic Translation Initiation Factor 5A; Lysine; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Rodentia | 1996 |
Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts.
Topics: Antineoplastic Agents; Cells, Cultured; Cellular Senescence; Diploidy; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Lung; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Substrate Specificity | 1997 |
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Lysine; Mice; Oncogene Protein p21(ras); Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1997 |
Interferon alpha2 recombinant and epidermal growth factor modulate proliferation and hypusine synthesis in human epidermoid cancer KB cells.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Epidermal Growth Factor; Exotoxins; Humans; Interferon alpha-2; Interferon-alpha; Lysine; Ornithine Decarboxylase; Oropharyngeal Neoplasms; Recombinant Proteins; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1997 |
Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis.
Topics: Animals; Apoptosis; Cell Division; Diamines; Eflornithine; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Lysine; Microscopy, Electron; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Peptide Initiation Factors; Polyamines; Protein Processing, Post-Translational; Putrescine; Rats; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1).
Topics: Anti-HIV Agents; Apoptosis; Cell Line, Transformed; Deferiprone; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; HIV Core Protein p24; HIV-1; Humans; Lysine; Microscopy, Electron; Mimosine; Mixed Function Oxygenases; Peptide Initiation Factors; Pyridones; RNA-Binding Proteins; RNA, Messenger; RNA, Viral; T-Lymphocytes; Virus Replication | 1998 |
Synthesis of reagents for the construction of hypusine and deoxyhypusine peptides and their application as peptidic antigens.
Topics: Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Eukaryotic Translation Initiation Factor 5A; Haptens; Hemocyanins; Humans; Lysine; Maleimides; Mice; Mice, Inbred BALB C; Oligopeptides; Ovalbumin; Peptide Initiation Factors; RNA-Binding Proteins; Stereoisomerism | 1998 |
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured | 1998 |
Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells.
Topics: 3T3 Cells; Animals; Cell Division; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Lysine; Mice; Mice, Inbred BALB C; Peptide Initiation Factors; Polyamines; RNA-Binding Proteins; Time Factors; Transfection; Transglutaminases | 1998 |
Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation.
Topics: Amino Acid Sequence; Animals; Binding Sites; Humans; Lysine; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; Saccharomyces cerevisiae | 1999 |
Cloning and analysis of cDNAs encoding the hypusine-containing protein eIF5A of two lepidopteran insect species.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Cloning, Molecular; DNA, Complementary; Eukaryotic Translation Initiation Factor 5A; Gene Dosage; Gene Expression; Lysine; Molecular Sequence Data; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Spodoptera | 1999 |
Cell cycle arrest in archaea by the hypusination inhibitor N(1)-guanyl-1,7-diaminoheptane.
Topics: Cell Cycle; Enzyme Inhibitors; Escherichia coli; Flow Cytometry; Guanine; Lysine; Sulfolobus acidocaldarius | 2000 |
Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy.
Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Chelating Agents; Cytarabine; Deferoxamine; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Translation Initiation Factor 5A; Exotoxins; Humans; Interferon-gamma; Iron; Kinetics; Leukemia; Lysine; Oropharyngeal Neoplasms; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1999 |
Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA.
Topics: Antigen Presentation; Antigens, CD; Biological Transport; CD83 Antigen; Cell Compartmentation; Cell Differentiation; Cell Nucleus; Dendritic Cells; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Immunoglobulins; Lymphocyte Activation; Lysine; Membrane Glycoproteins; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger; T-Lymphocytes; Up-Regulation | 2000 |
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Nucleus; Chromatography, Affinity; Cloning, Molecular; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Eukaryotic Translation Initiation Factor 5A; GTP Phosphohydrolases; HeLa Cells; Humans; Karyopherins; Kinetics; Lysine; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Nuclear Proteins; Peptide Initiation Factors; Protein Binding; Protein Structure, Tertiary; ran GTP-Binding Protein; RNA; RNA-Binding Proteins; Time Factors | 2000 |
Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with postsystematic evolution of ligands by exponential enrichment RNA.
Topics: Base Sequence; Consensus Sequence; Directed Molecular Evolution; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Gene Products, rev; Humans; Ligands; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Response Elements; RNA; RNA-Binding Proteins | 2001 |
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
Topics: Binding Sites; Eukaryotic Initiation Factor-5; Humans; Hydrogen-Ion Concentration; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Spermidine; Substrate Specificity; Time Factors | 2000 |
Asymmetric synthesis of (+)-hypusine.
Topics: Amino Acid Sequence; Lysine; Magnetic Resonance Spectroscopy; Molecular Structure | 2001 |
Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin.
Topics: Animals; Antibiotics, Antineoplastic; Eukaryotic Translation Initiation Factor 5A; Female; Guanidines; Lysine; Mice; Models, Chemical; Peptide Initiation Factors; Putrescine; RNA Caps; RNA-Binding Proteins; RNA, Messenger; Spermidine; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging.
Topics: 3T3 Cells; Active Transport, Cell Nucleus; Animals; Calnexin; Cell Nucleus; Cell Survival; COS Cells; Eukaryotic Initiation Factors; Eukaryotic Translation Initiation Factor 5A; Exportin 1 Protein; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins; HeLa Cells; Humans; Karyopherins; Luminescent Proteins; Lysine; Mice; Nuclear Localization Signals; Peptide Initiation Factors; Protein Transport; Receptors, Cytoplasmic and Nuclear; RNA-Binding Proteins | 2002 |
Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis.
Topics: Apoptosis; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Humans; Laminin; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Proteoglycans; RNA-Binding Proteins; Time Factors; Umbilical Veins | 2002 |
Crystal structure of hyperthermophilic archaeal initiation factor 5A: a homologue of eukaryotic initiation factor 5A (eIF-5A).
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Eukaryotic Translation Initiation Factor 5A; Lysine; Models, Molecular; Molecular Sequence Data; Peptide Initiation Factors; Protein Structure, Tertiary; RNA; RNA-Binding Proteins; Sequence Homology, Amino Acid; Structural Homology, Protein | 2003 |
The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-alpha and EGF in human cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Combinations; Epidermal Growth Factor; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Interferon-alpha; KB Cells; Lysine; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphorylation; Protein Processing, Post-Translational; RNA-Binding Proteins | 2003 |
Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Diamines; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Megakaryoblastic, Acute; Leupeptins; Lysine; Multienzyme Complexes; Oligodeoxyribonucleotides, Antisense; Peptide Initiation Factors; Peptide Mapping; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteomics; RNA-Binding Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subcellular Fractions; Tumor Cells, Cultured; Ubiquitin | 2003 |
[The effect of eIF-5A on the G1-S in cell cycle regulation].
Topics: Cell Line, Tumor; Diamines; Eukaryotic Translation Initiation Factor 5A; G1 Phase; Humans; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; S Phase | 2003 |
Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.
Topics: Base Sequence; DNA, Fungal; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Kinetics; Lysine; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamine Oxidase; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spermidine; Spermine; Substrate Specificity | 2003 |
Independent roles of eIF5A and polyamines in cell proliferation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cyclohexylamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Half-Life; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Putrescine; Rats; RNA-Binding Proteins; Spermine | 2005 |
Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy.
Topics: Anti-HIV Agents; Cells, Cultured; Drug Resistance, Multiple; Gene Expression Regulation, Viral; Gene Products, rev; HIV Infections; HIV-1; Humans; Hydrazones; Kinetics; Lysine; Macrophages; Oxidoreductases Acting on CH-NH Group Donors; Phenotype; rev Gene Products, Human Immunodeficiency Virus; RNA Interference; T-Lymphocytes; Transcriptional Activation; Virus Replication | 2005 |
Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex.
Topics: Arginine; Binding Sites; Chromatography, Affinity; Eukaryotic Translation Initiation Factor 5A; Humans; Ligands; Lysine; Mass Spectrometry; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Ribosomal Proteins; Ribosomes; RNA-Binding Proteins | 2006 |
Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.
Topics: Base Sequence; Cell Line; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Sequence Data; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyadenylation; Polyribosomes; Protein Biosynthesis; Protein Isoforms; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; RNA, Messenger; Transfection | 2006 |
eIF5A binds to translational machinery components and affects translation in yeast.
Topics: Eukaryotic Translation Initiation Factor 5A; Lysine; Mutation; Peptide Chain Elongation, Translational; Peptide Initiation Factors; Protein Biosynthesis; Protein Synthesis Inhibitors; Ribosomes; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2006 |
Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Proliferation; Down-Regulation; Drug Delivery Systems; Drug Synergism; Eukaryotic Translation Initiation Factor 5A; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; K562 Cells; Leukemia; Lysine; Peptide Initiation Factors; Piperazines; Protein Processing, Post-Translational; Proteomics; Pyrimidines; RNA-Binding Proteins | 2007 |
Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.
Topics: Animals; Arginase; Cell Proliferation; Cell Survival; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Hippocampus; Lysine; Models, Biological; Nerve Growth Factor; Neurons; PC12 Cells; Peptide Initiation Factors; Polyamines; Rats; RNA-Binding Proteins | 2007 |
An archaeal protein with homology to the eukaryotic translation initiation factor 5A shows ribonucleolytic activity.
Topics: Amino Acid Sequence; Archaeal Proteins; Base Sequence; Cells, Cultured; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Genetic Vectors; Halobacterium; Ligands; Lysine; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Initiation Factors; Protein Processing, Post-Translational; Ribonucleases; RNA-Binding Proteins; RNA, Archaeal; RNA, Messenger; Sequence Homology, Nucleic Acid | 2007 |
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Models, Biological; Pancreatitis; Peptide Initiation Factors; Polyamines; Rats; Recombinant Proteins; RNA-Binding Proteins; Spermidine; Stereoisomerism | 2007 |
Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.
Topics: Amino Acid Sequence; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Mutation; Peptide Initiation Factors; Protein Modification, Translational; RNA-Binding Proteins; Saccharomyces cerevisiae | 2008 |
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine.
Topics: Eukaryotic Translation Initiation Factor 5A; Intracellular Space; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine; Tritium | 2008 |
Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation.
Topics: Animals; Arginine; Cell Differentiation; Cell Proliferation; Chromatin; Connectin; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation; Guanine; Lysine; Male; Muscle Proteins; Muscle, Skeletal; MyoD Protein; Oxidation-Reduction; Peptide Initiation Factors; Protein Biosynthesis; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Satellite Cells, Skeletal Muscle; Stem Cells | 2009 |
Dimerization of the yeast eukaryotic translation initiation factor 5A requires hypusine and is RNA dependent.
Topics: Crystallography, X-Ray; Eukaryotic Translation Initiation Factor 5A; Lysine; Models, Molecular; Neurospora crassa; Peptide Initiation Factors; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; RNA-Binding Proteins; RNA, Fungal; Saccharomyces cerevisiae | 2009 |
Cloning and characterization of hypusine-containing protein eIF5A from the olive flounder Paralichthys olivaceus.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Eukaryotic Translation Initiation Factor 5A; Flounder; Glycoproteins; Guanine; Kidney; Lysine; Molecular Sequence Data; Novirhabdovirus; Peptide Initiation Factors; Phylogeny; RNA-Binding Proteins; Viral Proteins | 2009 |
The effect of hypusine modification on the intracellular localization of eIF5A.
Topics: Acetylation; Cell Line; Cytoplasm; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mutation; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins | 2009 |
Hypusine-containing protein eIF5A promotes translation elongation.
Topics: Eukaryotic Translation Initiation Factor 5A; Indenes; Lysine; Mutation; Peptide Chain Elongation, Translational; Peptide Elongation Factors; Peptide Initiation Factors; Polyribosomes; Protein Synthesis Inhibitors; Recombinant Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae | 2009 |
Completing the hypusine pathway in Plasmodium.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Gas Chromatography-Mass Spectrometry; Lysine; Mixed Function Oxygenases; Molecular Sequence Data; Molecular Structure; Plasmodium; Polymerase Chain Reaction; Protozoan Proteins; Sequence Homology, Amino Acid | 2009 |
Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.
Topics: Anti-HIV Agents; Ciclopirox; Deferiprone; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Gene Expression; HIV-1; Humans; Leukocytes, Mononuclear; Lysine; Mixed Function Oxygenases; Peptide Initiation Factors; Pyridones; RNA-Binding Proteins; Virus Replication | 2009 |
eIF5A promotes translation elongation, polysome disassembly and stress granule assembly.
Topics: Arsenites; Cell Line, Tumor; Cytoplasmic Granules; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Peptide Initiation Factors; Polyribosomes; Protein Biosynthesis; RNA-Binding Proteins; RNA, Small Interfering; Stress, Physiological | 2010 |
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
Topics: Animals; Eukaryotic Translation Initiation Factor 5A; Islets of Langerhans; Lysine; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Peptide Initiation Factors; RNA-Binding Proteins | 2010 |
PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica.
Topics: Animals; Bacterial Proteins; Drug Resistance, Microbial; Female; Gene Expression Regulation, Bacterial; Genomic Islands; Lysine; Lysine-tRNA Ligase; Mice; Peptide Elongation Factors; Protein Processing, Post-Translational; Salmonella enterica; Virulence Factors | 2010 |
Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).
Topics: Acetylation; Acetyltransferases; Animals; Cattle; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; Protein Binding; RNA-Binding Proteins | 2011 |
Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.
Topics: Animals; Cattle; Cloning, Molecular; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Genetic Vectors; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Recombinant Proteins; RNA-Binding Proteins; Temperature; Time Factors | 2011 |
A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different diseases.
Topics: Animals; Antimalarials; Catalytic Domain; Chromatography, High Pressure Liquid; Eukaryotic Initiation Factor-5; Humans; Lysine; Malaria; Mice; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Plasmodium; Protein Hydrolysates | 2012 |
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Methylation; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 2012 |
Proteomic profiling of germ cell cancer cells treated with aaptamine, a marine alkaloid with antiproliferative activity.
Topics: Amino Acid Sequence; Antineoplastic Agents; Biological Products; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; HEK293 Cells; Humans; Lysine; Molecular Sequence Data; Naphthyridines; Neoplasms, Germ Cell and Embryonal; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Proteins; Proteome; Proteomics; Reproducibility of Results; RNA-Binding Proteins | 2012 |
A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA, Protozoan; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Genes, Protozoan; Humans; In Vitro Techniques; Leishmania donovani; Lysine; Metabolic Networks and Pathways; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Insertional; Peptide Initiation Factors; Phylogeny; Protozoan Proteins; Recombinant Proteins; RNA-Binding Proteins; Sequence Homology, Amino Acid; Species Specificity | 2012 |
A tumour suppressor network relying on the polyamine-hypusine axis.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Female; Gene Deletion; Gene Regulatory Networks; Genetic Testing; Humans; Lymphoma, B-Cell; Lysine; Mice; Mice, Inbred C57BL; Polyamines; Reproducibility of Results; RNA, Small Interfering; Tumor Suppressor Proteins | 2012 |
Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A).
Topics: Acetylation; Active Transport, Cell Nucleus; Eukaryotic Translation Initiation Factor 5A; Gene Knockdown Techniques; HEK293 Cells; HeLa Cells; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Lysine; p300-CBP Transcription Factors; Peptide Initiation Factors; Recombinant Proteins; RNA-Binding Proteins; RNA, Small Interfering; Sirtuin 2; Subcellular Fractions | 2012 |
Protein-protein-interaction network organization of the hypusine modification system.
Topics: Animals; Computational Biology; DNA-Binding Proteins; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mass Spectrometry; Mice; Mixed Function Oxygenases; Multivesicular Bodies; NIH 3T3 Cells; Nuclear Proteins; Nucleophosmin; Oxidoreductases Acting on CH-NH Group Donors; Peptide Fragments; Peptide Initiation Factors; Protein Interaction Maps; Protein Processing, Post-Translational; Protein Transport; Recombinant Fusion Proteins; Reproducibility of Results; Ribosomal Proteins; RNA-Binding Proteins; Subcellular Fractions | 2012 |
Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Dacarbazine; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Lysine; Male; Mixed Function Oxygenases; Molecular Targeted Therapy; Neoplasm Grading; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Temozolomide | 2012 |
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
Topics: Animals; Cattle; Escherichia coli; Gene Knockdown Techniques; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Protozoan Proteins; Recombinant Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, Bovine | 2013 |
The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.
Topics: Adaptor Proteins, Signal Transducing; Cell Wall; Epistasis, Genetic; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation, Fungal; GTP-Binding Proteins; Lysine; Mutation, Missense; Oxidoreductases Acting on CH-NH Group Donors; Peptide Chain Elongation, Translational; Peptide Initiation Factors; Polyribosomes; Protein Binding; Protein Kinase C; Ribosome Subunits, Small, Eukaryotic; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Deletion | 2013 |
A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
Topics: 3T3 Cells; Alleles; Animals; Caenorhabditis elegans; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Senescence; Disease Models, Animal; Embryo Loss; Embryonic Development; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Gene Knockout Techniques; Hydroxylation; Lysine; Mice; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Phenotype; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; ras Proteins; RNA-Binding Proteins | 2014 |
Cryptosporidium parvum has an active hypusine biosynthesis pathway.
Topics: Biosynthetic Pathways; Cryptosporidiosis; Cryptosporidium parvum; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Phylogeny; Protozoan Proteins | 2014 |
The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
Topics: Autophagy; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Fibrosarcoma; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 2014 |
A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Ciclopirox; Deoxycytidine; Eukaryotic Translation Initiation Factor 5A; Female; Gemcitabine; Humans; Lysine; Mice; Pancreatic Neoplasms; Peptide Initiation Factors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyridones; ras Proteins; RNA-Binding Proteins | 2014 |
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
Topics: Biological Transport; Cell Line, Tumor; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Male; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine; Stereoisomerism; Substrate Specificity | 2015 |
Development of orthogonally protected hypusine for solid-phase peptide synthesis.
Topics: Amino Acid Sequence; Amino Acids; Indicators and Reagents; Lysine; Molecular Structure; Peptides; Pyrrolidinones; Solid-Phase Synthesis Techniques | 2015 |
Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.
Topics: Catalytic Domain; Crystallography, X-Ray; Enzyme Stability; Eukaryotic Translation Initiation Factor 5A; Glycerol; Humans; Lysine; Mixed Function Oxygenases; Models, Molecular; Molecular Docking Simulation; Peptide Initiation Factors; RNA-Binding Proteins; Substrate Specificity | 2015 |
Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
Topics: Animals; Homeostasis; Humans; Lysine; Mice; Mice, Knockout; Mixed Function Oxygenases; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Biosynthesis; Protein Interaction Maps; Protein Processing, Post-Translational | 2015 |
Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.
Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation; Luteinizing Hormone; Lysine; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Ovary; Peptide Initiation Factors; Phosphotransferases (Alcohol Group Acceptor); Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, LH; RNA-Binding Proteins; RNA, Messenger | 2015 |
Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Affinity; Crystallography, X-Ray; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; RNA-Binding Proteins | 2016 |
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
Topics: Adult; Aged; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diamines; Disease Progression; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Expression Regulation, Neoplastic; Humans; Lysine; Male; Mice; Middle Aged; Neoplasm Metastasis; Oxidoreductases Acting on CH-NH Group Donors; rhoA GTP-Binding Protein; Signal Transduction | 2016 |
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
Topics: Animals; Cell Line; Cells, Cultured; Cord Factors; Cytokines; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Granuloma; Immunoblotting; Inflammation; Lectins, C-Type; Lysine; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium tuberculosis; NIH 3T3 Cells; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Protein Biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Toll-Like Receptors | 2016 |
Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence.
Topics: Eukaryotic Translation Initiation Factor 5A; Fusarium; Gene Expression; Genes, Fungal; Lysine; Microbial Viability; Mutation; Mycotoxins; Peptide Initiation Factors; Plant Diseases; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA-Binding Proteins; Stress, Physiological; Triticum; Virulence | 2016 |
Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.
Topics: Cell Proliferation; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Lysine; Mutation; Peptide Elongation Factor 2; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Ribosomes; RNA-Binding Proteins; Up-Regulation | 2016 |
Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.
Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Genetic Vectors; Humans; Karyopherins; Kinetics; Lysine; Molecular Docking Simulation; Peptide Initiation Factors; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; ran GTP-Binding Protein; Recombinant Proteins; RNA-Binding Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thermodynamics | 2016 |
Alternative Start Codon Connects eIF5A to Mitochondria.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Codon, Initiator; Computer Simulation; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Lysine; Mitochondria; Peptide Initiation Factors; Protein Biosynthesis; Protein Isoforms; Protein Processing, Post-Translational; RNA-Binding Proteins | 2016 |
Hypusination of eIF5A as a Target for Antiviral Therapy.
Topics: Animals; Antiviral Agents; Drug Delivery Systems; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Signal Transduction; Virus Diseases; Virus Replication | 2017 |
Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis.
Topics: Amino Acids; Base Sequence; Eukaryotic Translation Initiation Factor 5A; Lysine; Nucleic Acid Conformation; Peptide Biosynthesis; Peptide Initiation Factors; Peptides; Polyamines; Proline; Ribosomes; RNA-Binding Proteins; RNA, Transfer, Phe; RNA, Transfer, Pro; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2017 |
KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop.
Topics: Animals; Carcinoma, Pancreatic Ductal; Eukaryotic Translation Initiation Factor 5A; Feedback, Physiological; Female; Glutamine; GTP Phosphohydrolases; Humans; Lysine; Membrane Proteins; Mice, Nude; Pancreatic Neoplasms; Peptide Initiation Factors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); RNA-Binding Proteins; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
Modification of translation factor aIF5A from Sulfolobus solfataricus.
Topics: Archaeal Proteins; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Sulfolobus solfataricus | 2018 |
Insulin action on protein synthesis and its association with eIF5A expression and hypusination.
Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Eukaryotic Translation Initiation Factor 5A; Insulin; Lysine; Myoblasts; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; Rats; RNA-Binding Proteins; Signal Transduction | 2019 |
Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
Topics: Alleles; Amino Acid Sequence; Child; Child, Preschool; Developmental Disabilities; Eukaryotic Translation Initiation Factor 5A; Female; Genes, Recessive; Haplotypes; Humans; Lysine; Male; Metabolism, Inborn Errors; Mutation; Neurodevelopmental Disorders; Oxidoreductases Acting on CH-NH Group Donors; Pedigree; Peptide Initiation Factors; RNA-Binding Proteins; Seizures; Young Adult | 2019 |
Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne.
Topics: Animals; Biliverdine; Biomarkers; Chromatography, Liquid; Creatine; Genotype; Longitudinal Studies; Lysine; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Prednisolone; Principal Component Analysis | 2019 |
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Topics: Aged; Alleles; Animals; Cell Proliferation; Crosses, Genetic; Cyclin D2; Diabetes Mellitus, Experimental; Diet, High-Fat; Eukaryotic Translation Initiation Factor 5A; Female; Gene Deletion; Glucose; Homeostasis; Humans; Insulin-Secreting Cells; Lysine; Male; Mice; Mice, Inbred C57BL; Middle Aged; Ornithine Decarboxylase; Peptide Initiation Factors; Polyamines; Protein Kinase C; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins; RNA, Messenger | 2019 |
Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
Topics: Adult; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Eukaryotic Translation Initiation Factor 5A; Female; Humans; Insulin-Secreting Cells; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Middle Aged; Pancreas; Pancreatic Polypeptide-Secreting Cells; Peptide Initiation Factors; RNA-Binding Proteins; Spleen; Young Adult | 2020 |
Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase.
Topics: Humans; Lysine; Models, Molecular; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Protein Conformation | 2020 |
Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes.
Topics: Apoptosis; Cell Proliferation; Colonic Neoplasms; Eukaryotic Translation Initiation Factor 5A; Gene Expression Regulation, Neoplastic; Humans; Lysine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; Ribosomes; RNA-Binding Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2020 |
Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy.
Topics: Animals; Behavior, Animal; Cognition; Eukaryotic Translation Initiation Factor 5A; Guanine; Injections, Intraperitoneal; Ischemic Attack, Transient; Lysine; Male; Mice; Mice, Inbred C57BL; Mitochondria; Models, Animal; Neuroprotection; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Reactive Oxygen Species; RNA-Binding Proteins; Stroke | 2021 |
Flexible NAD
Topics: Binding Sites; Crystallography, X-Ray; Eukaryota; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spermidine | 2020 |
De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells.
Topics: Animals; Cells, Cultured; Eukaryotic Translation Initiation Factor 5A; Female; Glycolysis; Killer Cells, Natural; Lysine; Male; Mice; Mice, Inbred C57BL; Oxidative Phosphorylation; Peptide Initiation Factors; Polyamines; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins; Sterol Regulatory Element Binding Proteins | 2021 |
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.
Topics: Adenomatous Polyposis Coli; Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lysine; Mice, Nude; Open Reading Frames; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Peptides; Polyamines; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins | 2020 |
Hypusination Orchestrates the Antimicrobial Response of Macrophages.
Topics: Animals; Anti-Infective Agents; Disease Models, Animal; Humans; Lysine; Macrophages; Mice | 2020 |
Yeast Translation Elongation Factor eIF5A Expression Is Regulated by Nutrient Availability through Different Signalling Pathways.
Topics: Aerobiosis; Carbon; Citric Acid Cycle; Down-Regulation; Eukaryotic Translation Initiation Factor 5A; Fermentation; Gene Expression Regulation, Fungal; Glucose; Heme; Iron; Iron Deficiencies; Lysine; Mechanistic Target of Rapamycin Complex 1; Metabolic Flux Analysis; Models, Biological; Nutrients; Peptide Initiation Factors; Protein Isoforms; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Up-Regulation | 2020 |
Alternative human eIF5A protein isoform plays a critical role in mitochondria.
Topics: Apoptosis; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Microscopy, Electron, Transmission; Mitochondria; Peptide Initiation Factors; Protein Isoforms; RNA-Binding Proteins | 2021 |
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
Topics: Adolescent; Amino Acid Sequence; Animals; Child; Developmental Disabilities; Embryo, Nonmammalian; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Developmental; Humans; Lysine; Male; Microcephaly; Micrognathism; Peptide Initiation Factors; Peptides; Protein Biosynthesis; Protein Conformation; Protein Isoforms; Ribosomes; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spermidine; Zebrafish; Zebrafish Proteins | 2021 |
Eukaryotic translation initiation factor 5A and its posttranslational modifications play an important role in proliferation and potentially in differentiation of the human enteric protozoan parasite Entamoeba histolytica.
Topics: Cell Differentiation; Cell Proliferation; Entamoeba histolytica; Entamoebiasis; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins | 2021 |
Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development.
Topics: Animals; Cell Proliferation; Eukaryotic Translation Initiation Factor 5A; Female; Lysine; Male; Mice; Mice, Knockout; Organogenesis; Oxidoreductases Acting on CH-NH Group Donors; Pancreas, Exocrine; Peptide Initiation Factors; Protein Biosynthesis; Protein Processing, Post-Translational; RNA-Binding Proteins | 2021 |
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
Topics: Administration, Oral; Aging, Premature; Animals; Brain; Cell Respiration; Drosophila melanogaster; Drosophila Proteins; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Locomotion; Lysine; Memory; Mitochondria; Mitochondrial Proteins; Models, Animal; Neurons; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 2021 |
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Topics: Animals; Cell Differentiation; Cell Lineage; Cell Polarity; Cell Proliferation; Chromatin; Citric Acid Cycle; Colitis; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Epigenome; Histones; Inflammation; Lymphocyte Subsets; Lysine; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Polyamines; T-Lymphocytes, Helper-Inducer; Th17 Cells; Transcription Factors | 2021 |
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Topics: Animals; Cerebellar Cortex; Cognition; Eukaryotic Translation Initiation Factor 5A; Hippocampus; Humans; Lysine; Mice; Mice, Knockout; Mixed Function Oxygenases; Neurogenesis; Neurons; Organ Specificity; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins | 2021 |
Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder.
Topics: Alleles; Gene Expression; Humans; Lysine; Mixed Function Oxygenases; Neurodevelopmental Disorders | 2022 |
The first evidence of biological activity for free Hypusine, an enigmatic amino acid discovered in the '70s.
Topics: Amino Acids; Animals; Cattle; Eukaryotic Translation Initiation Factor 5A; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Rats; Temozolomide | 2023 |