Page last updated: 2024-09-03

hypothiocyanite ion and mocetinostat

hypothiocyanite ion has been researched along with mocetinostat in 41 studies

Compound Research Comparison

Studies
(hypothiocyanite ion)
Trials
(hypothiocyanite ion)
Recent Studies (post-2010)
(hypothiocyanite ion)
Studies
(mocetinostat)
Trials
(mocetinostat)
Recent Studies (post-2010) (mocetinostat)
9772421,7353908,606
4703721,7353908,606

Protein Interaction Comparison

ProteinTaxonomyhypothiocyanite ion (IC50)mocetinostat (IC50)
Histone deacetylase 3Homo sapiens (human)0.7851
Nuclear receptor corepressor 1Homo sapiens (human)0.022
Cytochrome P450 3A4Homo sapiens (human)0.57
Cytochrome P450 2D6Homo sapiens (human)0.102
Cytochrome P450 2C19Homo sapiens (human)0.102
Histone deacetylase 4Homo sapiens (human)0.5717
Histone deacetylase 1Homo sapiens (human)0.3433
Histone deacetylase 7Homo sapiens (human)0.6725
Histone deacetylase 2Homo sapiens (human)0.3537
Histone deacetylase 11 Homo sapiens (human)0.6386
Histone deacetylase 8Homo sapiens (human)0.6725
Histone deacetylase 6Homo sapiens (human)0.5717
Histone deacetylase 5Homo sapiens (human)0.6725
Nuclear receptor corepressor 2Homo sapiens (human)0.045

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.32)18.7374
1990's10 (24.39)18.2507
2000's3 (7.32)29.6817
2010's22 (53.66)24.3611
2020's3 (7.32)2.80

Authors

AuthorsStudies
Emilson, CG; Lenander-Lumikari, M; Tenovuo, J; Vilja, P1
Binet, C; Courtois, PR; Pourtois, M; Thirty, L; Van Tieghem, N; Vandenabbeele, A1
Grisham, MB; Ryan, EM1
Gråhn, E; Hyyppä, T; Karhuvaara, L; Lehtonen, OP; Tenovuo, J; Vilja, P1
Baldone, DC; Mansson-Rahemtulla, B; Pruitt, KM; Rahemtulla, F1
Golding, MP; Lamberts, BL; Pederson, ED; Pruitt, KM1
Hannuksela, S; Lenander-Lumikari, M; Tenovuo, J1
Mikola, H; Tenovuo, J; Waris, M1
Ekstrand, J; Hannuksela, S; Lenander-Lumikari, M; Roger, V; Tenovuo, J1
Krig, MA; Neuvar, EK; Rudney, JD1
Kirstilä, V; Meurman, O; Ruuskanen, O; Suonpää, J; Tenovuo, J; Vilja, P1
Azcurra, AI; Battellino, LJ; Calamari, SE; Cattoni, ST; Colantonio, G; Yankilevich, ER1
Arlandson, M; Bonilla, L; Decker, T; Hazen, SL; MacPherson, JC; Mayo, KH; Roongta, VA; Slungaard, A1
Hayasawa, H; Imoto, I; Shin, K; Teraguchi, S; Yamauchi, K1
Azcurra, A; Battellino, LJ; Calamari, S; Cornejo, LS; Dorronsoro de Cattoni, ST; Femopase, F; López de Blanc, S1
Arnhold, J; Flemmig, J; Furtmüller, PG; Gau, J; Obinger, C; Schlorke, D1
Barrett, TJ; Brown, BE; Davies, MJ; Hawkins, CL; Ismael, FO; Sheipouri, D1
Ashby, MT; Lemma, K1
Davies, MJ; Hawkins, CL; Heather, AK; Lane, AE; Tan, JT1
Bachana, R; Davies, MJ; Jain, VK; Morgan, PE; Pattison, DI; Priyadarsini, KI; Skaff, O1
Cook, NL; Davies, MJ; Hool, LC; Schöneich, C; Sharov, VS; Viola, HM1
Barrett, TJ; Carroll, KS; Davies, MJ; Hawkins, CL; Leonard, SE; Pattison, DI1
Davies, MJ; Hawkins, CL; Pattison, DI1
Celermajer, DS; Davies, MJ; Harmer, JA; Pattison, DI; Talib, J1
Cao, Z; Cheng, G; Li, H; Thannickal, VJ; Zhang, G1
Cook, NL; Davies, MJ; Pattison, DI1
Davies, MJ; Pattison, DI; Schiesser, CH; Storkey, C; White, JM1
Brown, BE; Davies, MJ; Hadfield, KA; Hawkins, CL; Hou, L; Pattison, DI; Rye, KA1
Davies, MJ; Kwan, J; Suryo Rahmanto, A; Talib, J; Witting, PK1
Davies, MJ; Grima, MA; Hadfield, KA; Hawkins, CL; Lloyd, MM; Rayner, BS1
Hawkins, CL; Love, DT; Rayner, BS1
Brown, BE; Croft, KD; Davies, MJ; Hawkins, CL; Ismael, FO; Proudfoot, JM; van Reyk, DM1
Barrett, TJ; Cordwell, SJ; Davies, MJ; Hawkins, CL; Love, DT; White, MY1
Hampton, MB; Kettle, AJ; Winterbourn, CC1
Abdo, AI; Hawkins, CL; Rayner, BS; van Reyk, DM1
Hawkins, CL; Pan, GJ; Rayner, BS; van Reyk, DM; Zhang, Y1
Hawkins, CL; Rayner, BS; Reyes, L1
Andrié, R; Becher, MU; Camara, B; Jansen, F; Lenart, MA; Nickenig, G; Niepmann, ST; Tiyerili, V; Zietzer, A1
Brazhe, NA; Guo, C; Hawkins, CL; Love, DT; Nikelshparg, EI; Sosnovtseva, O1
Hampton, MB; Hua, H; Kaldor, CD; Kettle, AJ; Parker, HA; Shearer, HL1
Bozonet, SM; Göbl, C; Hampton, MB; Heath, SG; Konigstorfer, A; Magon, NJ; Morris, VK; Murphy, JM; Salvesen, GS; Schwartfeger, AJ; Vissers, MCM1

Reviews

3 review(s) available for hypothiocyanite ion and mocetinostat

ArticleYear
Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids.
    Free radical research, 2012, Volume: 46, Issue:8

    Topics: Humans; Hydrogen Peroxide; Hypochlorous Acid; Kinetics; Oxidants; Oxidation-Reduction; Oxidative Stress; Peroxidase; Phagocytes; Sulfhydryl Compounds; Thiocyanates

2012
Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells.
    Free radical biology & medicine, 2014, Volume: 71

    Topics: Animals; Bromates; Calcium; Endothelial Cells; Epithelial Cells; Erythrocytes; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Intracellular Signaling Peptides and Proteins; Oxidants; Oxidative Stress; Peroxidase; Signal Transduction; Thiocyanates

2014
Reactive Oxygen Species and Neutrophil Function.
    Annual review of biochemistry, 2016, Jun-02, Volume: 85

    Topics: Cell Membrane; Cells, Cultured; Chloramines; Gene Expression; Humans; Hydrogen Peroxide; Hypochlorous Acid; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Oxidation-Reduction; Peroxidase; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Thiocyanates; Zymosan

2016

Trials

3 trial(s) available for hypothiocyanite ion and mocetinostat

ArticleYear
Longitudinal analysis of human salivary immunoglobulins, nonimmune antimicrobial agents, and microflora after tonsillectomy.
    Clinical immunology and immunopathology, 1996, Volume: 80, Issue:2

    Topics: Adolescent; Adult; Agglutinins; Anti-Bacterial Agents; Antibodies, Bacterial; Female; Humans; Immunoglobulins; Longitudinal Studies; Male; Muramidase; Peroxidase; Postoperative Period; Saliva; Streptococcus mutans; Thiocyanates; Tonsillectomy

1996
[Effects of local treatment with sodium fluoride mouthrinse on peroxidase and hypothiocyanite saliva levels in adolescent]/.
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1997, Volume: 47, Issue:4

    Topics: Adolescent; Dental Caries; Female; Fluorides, Topical; Humans; Male; Mouthwashes; Oral Hygiene; Peroxidase; Saliva; Sodium Fluoride; Thiocyanates

1997
Evolution of saliva and serum components in patients with oral candidosis topically treated with Ketoconazole and Nystatin.
    Acta odontologica latinoamericana : AOL, 1998, Volume: 11, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antifungal Agents; Candidiasis, Oral; Double-Blind Method; Female; Humans; Iron; Ketoconazole; Male; Middle Aged; Mouth Mucosa; Nystatin; Peroxidase; Protein Binding; Saliva; Thiocyanates; Treatment Outcome

1998

Other Studies

35 other study(ies) available for hypothiocyanite ion and mocetinostat

ArticleYear
Viability of Streptococcus mutans and Streptococcus sobrinus in whole saliva with varying concentrations of indigenous antimicrobial agents.
    Caries research, 1992, Volume: 26, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Antibodies, Bacterial; Female; Humans; Hydrogen-Ion Concentration; Immunoglobulin A, Secretory; Immunoglobulin G; Lactoferrin; Male; Muramidase; Peroxidase; Peroxidases; Saliva; Sterilization; Streptococcus mutans; Streptococcus sobrinus; Thiocyanates

1992
Saliva can contribute in quick inhibition of HIV infectivity.
    AIDS (London, England), 1991, Volume: 5, Issue:5

    Topics: Cell Line; Cells, Cultured; Gene Products, gag; HIV Core Protein p24; HIV-1; Humans; Kinetics; Lymphocytes; Peroxidase; Saliva; Thiocyanates; Viral Core Proteins

1991
Cytotoxic properties of salivary oxidants.
    The American journal of physiology, 1990, Volume: 258, Issue:1 Pt 1

    Topics: Erythrocytes; Glutathione; Hemoglobins; Hemolysis; Humans; Hydrogen-Ion Concentration; Kinetics; Methemoglobin; Models, Biological; Oxidation-Reduction; Peroxidase; Peroxidases; Saliva; Thiocyanates

1990
Antimicrobial factors in saliva: ontogeny and relation to oral health.
    Journal of dental research, 1987, Volume: 66, Issue:2

    Topics: Adult; Aging; Bacterial Physiological Phenomena; Child, Preschool; Humans; Immunoglobulin A, Secretory; Immunoglobulin G; Infant; Isoenzymes; Lactoferrin; Muramidase; Oral Health; Peroxidase; Peroxidases; Saliva; Salivary Proteins and Peptides; Thiocyanates; Tooth Eruption

1987
Effects of variations in pH and hypothiocyanite concentrations on S. mutans glucose metabolism.
    Journal of dental research, 1987, Volume: 66, Issue:2

    Topics: Glucose; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Isoenzymes; Peroxidase; Peroxidases; Salivary Proteins and Peptides; Streptococcus mutans; Thiocyanates

1987
Comparison of salivary peroxidase system components in caries-free and caries-active naval recruits.
    Caries research, 1984, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Anti-Infective Agents; Dental Caries; Humans; Hydrogen-Ion Concentration; Isoenzymes; Male; Peroxidase; Peroxidases; Saliva; Secretory Rate; Thiocyanates

1984
Effects of delmopinol on antimicrobial peroxidase systems and lysozyme in vitro and in human whole saliva.
    European journal of oral sciences, 1995, Volume: 103, Issue:4

    Topics: Anti-Infective Agents; Buffers; Enzyme Inhibitors; Humans; Lactoperoxidase; Morpholines; Muramidase; Peroxidase; Peroxidases; Saliva; Salivary Proteins and Peptides; Surface-Active Agents; Thiocyanates

1995
Inhibition of herpes simplex virus type 1, respiratory syncytial virus and echovirus type 11 by peroxidase-generated hypothiocyanite.
    Antiviral research, 1995, Volume: 26, Issue:2

    Topics: Adult; Antiviral Agents; Cells, Cultured; Enterovirus B, Human; Female; Fibroblasts; Gingiva; Herpesvirus 1, Human; Humans; Hydrogen-Ion Concentration; Immunoenzyme Techniques; Peroxidase; Respiratory Syncytial Viruses; Saliva; Thiocyanates

1995
Fluoride inhibits the antimicrobial peroxidase systems in human whole saliva.
    Caries research, 1994, Volume: 28, Issue:6

    Topics: Animals; Anti-Infective Agents; Buffers; Cattle; Dose-Response Relationship, Drug; Fluorides; Gels; Humans; Hydrogen-Ion Concentration; Lactoperoxidase; Male; Paint; Peroxidase; Peroxidases; Phosphates; Saliva; Salivary Proteins and Peptides; Thiocyanates; Toothpastes

1994
Longitudinal study of relations between human salivary antimicrobial proteins and measures of dental plaque accumulation and composition.
    Archives of oral biology, 1993, Volume: 38, Issue:5

    Topics: Bacteria; Circadian Rhythm; Colony Count, Microbial; Cross-Sectional Studies; Dental Plaque; Female; Humans; Immunoglobulin A, Secretory; Lactoferrin; Longitudinal Studies; Male; Muramidase; Peroxidase; Peroxidases; Saliva; Salivary Proteins and Peptides; Secretory Rate; Streptococcus; Streptococcus mutans; Streptococcus sanguis; Thiocyanates

1993
Eosinophil peroxidase oxidation of thiocyanate. Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system.
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Adenosine Triphosphatases; Cyanates; Eosinophil Peroxidase; Eosinophils; Erythrocytes; Glutathione; Glutathione Transferase; Hemolysis; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Neutrophils; Oxidants; Peroxidase; Peroxidases; Spectrometry, Mass, Electrospray Ionization; Temperature; Tetradecanoylphorbol Acetate; Thiocyanates

2001
Susceptibility of Helicobacter pylori and its urease activity to the peroxidase-hydrogen peroxide-thiocyanate antimicrobial system.
    Journal of medical microbiology, 2002, Volume: 51, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Buffers; Enzyme Inhibitors; Helicobacter Infections; Helicobacter pylori; Humans; Hydrogen Peroxide; Lactoperoxidase; Peroxidase; Saliva; Thiocyanates; Time Factors; Urease

2002
New insights into thiocyanate oxidation by human myeloperoxidase.
    Journal of inorganic biochemistry, 2016, Volume: 162

    Topics: Ferric Compounds; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Peroxidase; Solutions; Thiocyanates; Water

2016
Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Animals; Atherosclerosis; Cathepsins; Cell Line; Humans; Hypochlorous Acid; Lipase; Lipoproteins, LDL; Lysosomal Membrane Proteins; Lysosomes; Macrophages; Mice; Peroxidase; Thiocyanates

2016
Reactive sulfur species: kinetics and mechanism of the reaction of hypothiocyanous acid with cyanide to give dicyanosulfide in aqueous solution.
    Chemical research in toxicology, 2009, Volume: 22, Issue:9

    Topics: Cyanides; Glutathione; Humans; Hydrogen-Ion Concentration; Kinetics; Lung; Nitriles; Peroxidase; Smoking; Sulfides; Sulfur; Thiocyanates; Water

2009
The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages.
    The Biochemical journal, 2010, Aug-15, Volume: 430, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; Cell Line; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 14; Peroxidase; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Thiocyanates; Transcription Factors

2010
Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage.
    The Biochemical journal, 2012, Jan-01, Volume: 441, Issue:1

    Topics: Amino Acids; Erythrocytes; Glutathione Peroxidase; Humans; Kinetics; Male; Molecular Structure; Oxidation-Reduction; Peroxidase; Selenium; Thiocyanates; Thioredoxin-Disulfide Reductase

2012
Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells.
    Free radical biology & medicine, 2012, Mar-01, Volume: 52, Issue:5

    Topics: Calcium; Calcium Signaling; Cells, Cultured; Chloramines; Coronary Vessels; Endoplasmic Reticulum; Endothelial Cells; Humans; Hypochlorous Acid; Oxidants; Oxidation-Reduction; Peroxidase; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sulfhydryl Compounds; Thiocyanates

2012
Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates.
    Free radical biology & medicine, 2012, Mar-15, Volume: 52, Issue:6

    Topics: Animals; Catalytic Domain; Cell Line; Creatine Kinase; Enzyme Activation; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); Macrophages; Mice; Oxidative Stress; Peroxidase; Sulfenic Acids; Sulfhydryl Compounds; Thiocyanates

2012
High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine.
    Free radical biology & medicine, 2012, Jul-01, Volume: 53, Issue:1

    Topics: Biomarkers; Blood Proteins; Case-Control Studies; Female; Humans; Male; Oxidants; Oxidation-Reduction; Peroxidase; Smoking; Sulfhydryl Compounds; Thiocyanates; Tyrosine

2012
Vascular peroxidase 1 catalyzes the formation of hypohalous acids: characterization of its substrate specificity and enzymatic properties.
    Free radical biology & medicine, 2012, Nov-15, Volume: 53, Issue:10

    Topics: Biocatalysis; Bromates; Heme; Humans; Hydrogen Peroxide; Hypochlorous Acid; Kinetics; Oxidation-Reduction; Peroxidase; Peroxidases; Substrate Specificity; Taurine; Thiocyanates

2012
Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins.
    Free radical biology & medicine, 2012, Dec-01, Volume: 53, Issue:11

    Topics: Alcohol Dehydrogenase; Binding Sites; Bromates; Catalytic Domain; Coordination Complexes; Cysteine; Histidine; Hypochlorous Acid; Kinetics; Oxidants; Oxidation-Reduction; Peroxidase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiocyanates

2012
Preventing protein oxidation with sugars: scavenging of hypohalous acids by 5-selenopyranose and 4-selenofuranose derivatives.
    Chemical research in toxicology, 2012, Nov-19, Volume: 25, Issue:11

    Topics: Free Radical Scavengers; Hypochlorous Acid; Molecular Structure; Monosaccharides; Organoselenium Compounds; Oxidation-Reduction; Peroxidase; Thiocyanates

2012
Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl).
    The Biochemical journal, 2013, Jan-15, Volume: 449, Issue:2

    Topics: Amino Acid Sequence; Apolipoprotein A-I; Biological Transport; Cell Line; Cells, Cultured; Cholesterol; E-Selectin; Endothelium, Vascular; Female; Flow Cytometry; Humans; Hypochlorous Acid; Intercellular Adhesion Molecule-1; Lipoproteins, HDL; Macrophages; Male; Molecular Sequence Data; Oxidants; Oxidation-Reduction; Peptides; Peroxidase; Thiocyanates; Vascular Cell Adhesion Molecule-1

2013
The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction.
    The Biochemical journal, 2014, Jan-01, Volume: 457, Issue:1

    Topics: Animals; Cells, Cultured; Enzyme Activation; Humans; Hypochlorous Acid; Male; Nitric Oxide Synthase Type III; Oxidants; Peroxidase; Protein Multimerization; Rats; Rats, Wistar; Smoking; Thiocyanates

2014
Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells.
    Free radical biology & medicine, 2013, Volume: 65

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Atherosclerosis; Caspase 3; Caspase 7; Caspase Inhibitors; Cell Line; Cell Survival; Coronary Vessels; Cytochromes c; Endodeoxyribonucleases; Endothelial Cells; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Hydrogen Peroxide; Hypochlorous Acid; Mitochondrial Membranes; Necrosis; Oxidation-Reduction; Permeability; Peroxidase; Sulfhydryl Compounds; Thiocyanates

2013
Comparative reactivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein (LDL): Implications for foam cell formation in atherosclerosis.
    Archives of biochemistry and biophysics, 2015, May-01, Volume: 573

    Topics: Animals; Apolipoprotein B-100; Atherosclerosis; Cell Line; Cholesterol; Cholesterol Esters; Foam Cells; Humans; Hypochlorous Acid; Lipoproteins, LDL; Macrophages; Mice; Oxidants; Oxidation-Reduction; Peroxidase; Thiocyanates

2015
Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages.
    Free radical biology & medicine, 2016, Volume: 94

    Topics: Atherosclerosis; Cell Death; Cell Line; Glutathione; Glycolysis; Humans; Hydrogen Peroxide; Inflammation; Macrophages; Oxidants; Peroxidase; Protein Processing, Post-Translational; Proteomics; Sulfhydryl Compounds; Thiocyanates

2016
Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction.
    Redox biology, 2017, Volume: 13

    Topics: Animals; Aorta; Cells, Cultured; Endothelial Cells; Hypochlorous Acid; Lipoproteins, LDL; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Sprague-Dawley; Thiocyanates; Vasodilation

2017
A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid.
    Archives of biochemistry and biophysics, 2018, 03-15, Volume: 642

    Topics: Atherosclerosis; Cell Differentiation; Cell Line; Cell Survival; Chemokines; Cytokines; Humans; Inflammation; Inflammation Mediators; Macrophages; NF-kappa B; Peroxidase; Smoking; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Thiocyanates; Up-Regulation

2018
Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts.
    Archives of biochemistry and biophysics, 2019, 04-15, Volume: 665

    Topics: Animals; Cell Line; Glutathione; Hypochlorous Acid; Myoblasts, Cardiac; Oxidants; Oxidative Stress; Peroxidase; Rats; Signal Transduction; Thiocyanates

2019
Sodium thiocyanate treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice.
    PloS one, 2019, Volume: 14, Issue:4

    Topics: Animals; Aorta; Atherosclerosis; Blood Pressure; Body Weight; Carotid Arteries; Endothelium, Vascular; Granulocytes; Heart; Heart Rate; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Neointima; Neutrophils; Oxidative Stress; Peroxidase; Plaque, Atherosclerotic; Reactive Oxygen Species; Regeneration; Thiocyanates; Vasodilation

2019
The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages.
    Redox biology, 2020, Volume: 36

    Topics: Cell Line; Hypochlorous Acid; Macrophages; Mitochondria; Oxidants; Oxidation-Reduction; Peroxidase; Thiocyanates

2020
Resistance of Streptococcus pneumoniae to Hypothiocyanous Acid Generated by Host Peroxidases.
    Infection and immunity, 2022, 03-17, Volume: 90, Issue:3

    Topics: Humans; Hydrogen Peroxide; Hypochlorous Acid; Lactoperoxidase; Peroxidase; Peroxidases; Proteins; Streptococcus pneumoniae; Thiocyanates

2022
Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis.
    The Journal of biological chemistry, 2023, Volume: 299, Issue:6

    Topics: Animals; Caspase 8; Catalytic Domain; Fibroblasts; Inflammation; Lactoperoxidase; Mice; Necroptosis; Oxidants; Oxidation-Reduction; Peroxidase; Tumor Necrosis Factors

2023