Compounds > hypochlorous acid
Page last updated: 2024-08-22

hypochlorous acid and tyrosine

hypochlorous acid has been researched along with tyrosine in 78 studies

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (20.51)18.2507
2000's44 (56.41)29.6817
2010's16 (20.51)24.3611
2020's2 (2.56)2.80

Authors

AuthorsStudies
Vissers, MC; Winterbourn, CC1
Charlton, TS; Domigan, NM; Duncan, MW; Kettle, AJ; Winterbourn, CC1
Kettle, AJ2
Cross, CE; Eiserich, JP; Halliwell, B; Jones, AD; van der Vliet, A1
Hazen, SL; Heinecke, JW1
Heinecke, JW1
Halliwell, B; Whiteman, M2
Crowley, JR; Hazen, SL; Heinecke, JW; Mueller, DM1
Anderson, MM; d'Avignon, A; Hazen, SL; Heinecke, JW; Hsu, FF1
Beckman, JS; Rosen, H; Sampson, JB; Ye, Y1
Halliwell, B; Szabó, C; Whiteman, M1
Hazen, SL; Hegele, RA; Heinecke, JW; Huff, MW; Miller, DB; Whitman, SC1
Celan, I; Chazotte, L; Mower, HF; Ohshima, H; Pignatelli, B1
Baker, C; Evans, TW; Gutteridge, JM; Lamb, NJ; Quinlan, GJ1
Davies, M; Dean, R; Fu, S; Wang, H1
Kettle, AJ; Senthilmohan, R; van Dalen, CJ; Winterbourn, CC1
Celan, I; Friesen, MD; Masuda, M; Mower, HF; Nishino, H; Ohshima, H; Pignatelli, B1
Chapman, AL; Kettle, AJ; Senthilmohan, R; Winterbourn, CC1
Jasin, HE; Uesugi, M; Yoshida, K1
Alt, E; Exner, M; Gmeiner, B; Hermann, M; Hofbauer, R; Kapiotis, S; Minar, E; Quehenberger, P; Speiser, W1
Anderson, MM; Brennan, ML; Crowley, JR; Hazen, SL; Heinecke, JW; Jacob, JS; Lim, LL; Lusis, AJ; Mehta, AC; Qu, XD; Shi, W; Shih, DM; Wang, X1
Gieseg, SP; Glubb, D; Maghzal, G1
Pizzo, SV; Wu, SM1
Drabik, G; Naskalski, JW1
Lehnig, M1
Belaaouaj, A; Brennan, ML; Byun, J; Gaut, JP; Heinecke, JW; Henderson, JP; Hotchkiss, RS; Lusis, AJ; Richter, GM; Tran, HD; Yeh, GC1
Colombo, R; Dalle-Donne, I; Di Simplicio, P; Gagliano, N; Giustarini, D; Lusini, L; Milzani, A; Rossi, R1
Chapman, AL; Hampton, MB; Kettle, AJ; Senthilmohan, R; Winterbourn, CC1
Alderman, CJ; Chain, BM; Foreman, JC; Katz, DR; Shah, S1
Crowley, JR; Heinecke, JW; Rosen, H1
de Fex, H; Schieven, GL; Stephenson, L1
Halliwell, B; Siau, JL; Whiteman, M1
Crow, JP; Davis, IC; Matalon, S; Sampson, JB; Zhu, S1
Winterbourn, CC1
Auchère, F; Capeillère-Blandin, C1
Mak, P; Marcinkiewicz, J; Olszowska, E; Olszowski, S1
Bergt, C; Fu, X; Heinecke, JW; Huq, NP; Kao, J1
Kusior, D; Olszowska, E; Olszowski, S; Piwowarczyk, M; Stelmaszynska, T1
Bast, A; Haenen, GR; Rezk, BM; van der Vijgh, WJ1
Aviram, M; Szuchman, A; Tamir, S; Vaya, J1
Fisher, MT; Khor, HK; Schöneich, C1
Halliwell, B; Jenner, A; Peng, ZF; Tang, SY; Whiteman, M; Yong, EL1
Anantharamaiah, GM; Bergt, C; Brunzell, J; Byun, J; Chait, A; Fu, X; Geary, RL; Heinecke, JW; McDonald, TO; O'Brien, K; Oram, JF; Pennathur, S; Singh, P1
Chen, CL; Chen, YR; Li, H; Liu, X; Mason, RP; Zweier, JL1
Ark, M; Demiryurek, AT; Turan, NN1
Davies, MJ; Pattison, DI2
Choi, DK; Heinecke, JW; Jackson-Lewis, V; Pennathur, S; Perier, C; Przedborski, S; Teismann, P; Tieu, K; Vila, M; Vonsattel, JP; Wu, DC1
Aviram, M; Soliman, K; Szuchman, A; Tamir, S; Vaya, J1
Cárdenas-Rodríguez, N; Floriano-Sánchez, E; Medina-Campos, ON; Pedraza-Chaverrí, J; Rocha, D; Sánchez-González, DJ; Villanueva, C1
Pimental, D; Reece, R; Xie, Z; Xu, J; Zou, MH1
Khatib, S; Musa, R; Vaya, J1
Ippolito, S; Mani, AR; Moore, KP; Moreno, JC; Visser, TJ1
Spencer, JP; Whiteman, M1
Kang, JI; Neidigh, JW1
Gugliucci, A1
Haroune, N; Mouls, L; Pitt, AR; Silajdzic, E; Spickett, CM1
Amano, K; Kato, K; Nishiyama, K; Tachikawa, M; Urano, A; Yamanaka, K1
Chen, J; Chung, DW; Fu, X; Kulman, J; Ling, M; López, JA; McMullen, B; Wang, Y1
De Groote, D; Paquet, P; Piérard, GE1
Curtis, MP; Hicks, AJ; Neidigh, JW1
Arnhold, J; Sokolov, AV; Vlasova, II1
Heinecke, JW; Pennathur, S; Shao, B1
Barnes, S; Cao, Z; Cheng, G; Jackson, PL; Lambeth, JD; Li, H; Moore, DR; Thannickal, VJ1
Aseychev, AV; Azizova, OA; Beckman, EM; Dobretsov, GE; Gryzunov, YA; Moskvina, SN; Skotnikova, OI; Smolina, NV1
Chen, C; Hu, M; Lü, JM; Weakley, SM; Yang, Z; Yao, Q1
Bean, DJ; Howell, SC; McCurry, DL; Mitch, WA; Sivey, JD; Wilson, CJ1
Batteux, F; Chéreau, C; Dinh-Xuan, AT; Hua-Huy, T; Kavian, N; Marut, W; Nicco, C; Servettaz, A; Weill, B1
Curtis, MP; Neidigh, JW1
Badalamenti, S; Clerici, M; Colombo, G; Dalle-Donne, I; Giustarini, D; Milzani, A; Portinaro, N; Rossi, R1
Batteux, F; Bei, Y; Chéreau, C; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Le-Dong, NN; Nicco, C; Tiev, KP1
Cheng, D; Maghzal, GJ; Stocker, R; Talib, J1
Altomare, A; Clerici, M; Colombo, G; Dalle-Donne, I; Garavaglia, ML; Giustarini, D; Milzani, A; Portinaro, N; Rossi, R; Rusconi, F1
Davies, MJ; Nybo, T; Rogowska-Wrzesinska, A1
Davies, MJ; Fuentes-Lemus, E; Jiang, S1
Chuang, CY; Davies, MJ; Gamon, LF; Hawkins, CL; Malle, E; Xu, S1

Reviews

2 review(s) available for hypochlorous acid and tyrosine

ArticleYear
Pathways for oxidation of low density lipoprotein by myeloperoxidase: tyrosyl radical, reactive aldehydes, hypochlorous acid and molecular chlorine.
    BioFactors (Oxford, England), 1997, Volume: 6, Issue:2

    Topics: Aldehydes; Animals; Arteriosclerosis; Chlorine; Cholesterol, LDL; Free Radicals; Humans; Hypochlorous Acid; Lipoproteins, LDL; Macrophages; Oxidants; Oxidation-Reduction; Peroxidase; Tyrosine

1997
Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid.
    Toxicology, 2002, Dec-27, Volume: 181-182

    Topics: Animals; Biomarkers; Chlorohydrins; Humans; Hypochlorous Acid; Neutrophils; Oxidants; Oxidation-Reduction; Proteins; Sulfhydryl Compounds; Tyrosine

2002

Other Studies

76 other study(ies) available for hypochlorous acid and tyrosine

ArticleYear
Oxidative damage to fibronectin. I. The effects of the neutrophil myeloperoxidase system and HOCl.
    Archives of biochemistry and biophysics, 1991, Feb-15, Volume: 285, Issue:1

    Topics: Azides; Chloramines; Fibronectins; Fluorescence; Humans; Hydrogen Peroxide; Hypochlorous Acid; Methionine; Molecular Weight; Neutrophils; Pancreatic Elastase; Peroxidase; Protein Denaturation; Tryptophan; Tyrosine

1991
Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils.
    The Journal of biological chemistry, 1995, Jul-14, Volume: 270, Issue:28

    Topics: Amino Acid Sequence; Humans; Hypochlorous Acid; Molecular Sequence Data; Neutrophils; Oligopeptides; Peroxidase; Tyrosine

1995
Neutrophils convert tyrosyl residues in albumin to chlorotyrosine.
    FEBS letters, 1996, Jan-22, Volume: 379, Issue:1

    Topics: Amino Acid Sequence; Humans; Hypochlorous Acid; In Vitro Techniques; Inflammation; Molecular Sequence Data; Neutrophils; Oligopeptides; Peroxidase; Serum Albumin; Tyrosine

1996
Formation of nitrating and chlorinating species by reaction of nitrite with hypochlorous acid. A novel mechanism for nitric oxide-mediated protein modification.
    The Journal of biological chemistry, 1996, Aug-09, Volume: 271, Issue:32

    Topics: Hypochlorous Acid; Nitric Oxide; Nitrites; Phenylacetates; Serum Albumin, Bovine; Tyrosine

1996
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
    The Journal of clinical investigation, 1997, May-01, Volume: 99, Issue:9

    Topics: Aorta; Apolipoproteins B; Arteriosclerosis; Biomarkers; Chlorine; Humans; Hypochlorous Acid; Lipoproteins; Lipoproteins, LDL; Oxidation-Reduction; Peroxidase; Phagocytes; Tyrosine

1997
Thiols and disulphides can aggravate peroxynitrite-dependent inactivation of alpha1-antiproteinase.
    FEBS letters, 1997, Sep-15, Volume: 414, Issue:3

    Topics: alpha 1-Antitrypsin; Disulfides; Enzyme Activation; Hypochlorous Acid; Nitrates; Sulfhydryl Compounds; Tyrosine

1997
Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation.
    Free radical biology & medicine, 1997, Volume: 23, Issue:6

    Topics: Analysis of Variance; Aorta; Arteriosclerosis; Biomarkers; Calibration; Carbon; Carbon Isotopes; Catalysis; Chlorine; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypochlorous Acid; Inflammation; Lipoproteins, LDL; Male; Peroxidase; Sensitivity and Specificity; Tyrosine

1997
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize alpha-amino acids to a family of reactive aldehydes. Mechanistic studies identifying labile intermediates along the reaction pathway.
    The Journal of biological chemistry, 1998, Feb-27, Volume: 273, Issue:9

    Topics: Aldehydes; Amino Acids; Chloramines; Chlorides; Humans; Hypochlorous Acid; Lysine; Mass Spectrometry; Models, Chemical; Neutrophils; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Peroxidase; Phenylalanine; Tyrosine

1998
Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide.
    Archives of biochemistry and biophysics, 1998, Aug-15, Volume: 356, Issue:2

    Topics: Animals; Catalase; Catalysis; Horseradish Peroxidase; Hydrogen Peroxide; Hypochlorous Acid; Male; Myocardium; Nitrates; Nitrites; Peroxidase; Rats; Serum Albumin, Bovine; Tyrosine

1998
Detection of 3-chlorotyrosine in proteins exposed to neutrophil oxidants.
    Methods in enzymology, 1999, Volume: 300

    Topics: Blood Proteins; Chlorides; Chromatography, High Pressure Liquid; Electrochemistry; Fluorescence; Humans; Hydrogen Peroxide; Hypochlorous Acid; Neutrophils; Oxidants; Peroxidase; Tyrosine

1999
Loss of 3-nitrotyrosine on exposure to hypochlorous acid: implications for the use of 3-nitrotyrosine as a bio-marker in vivo.
    Biochemical and biophysical research communications, 1999, Apr-29, Volume: 258, Issue:1

    Topics: Biomarkers; Hypochlorous Acid; Reactive Oxygen Species; Tyrosine

1999
Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine.
    British journal of pharmacology, 1999, Volume: 126, Issue:7

    Topics: alpha 1-Antitrypsin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Humans; Hypochlorous Acid; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine

1999
Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages.
    Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:5

    Topics: Acetaldehyde; Animals; Apolipoproteins E; Arteriosclerosis; Cell Line; Cholesterol Esters; Esterification; Humans; Hyperlipoproteinemia Type III; Hypochlorous Acid; Interferon-gamma; Lipoprotein Lipase; Lipoproteins, VLDL; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Peroxidase; Phenol; Poly I; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class A; Scavenger Receptors, Class B; Sterol O-Acyltransferase; Triglycerides; Tyrosine

1999
Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agents.
    Nitric oxide : biology and chemistry, 1999, Volume: 3, Issue:2

    Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hypochlorous Acid; Indicators and Reagents; Molsidomine; Nitrates; Nitrites; Nitrogen Oxides; Serum Albumin, Bovine; Sodium Nitrite; Spectrophotometry, Ultraviolet; Spermine; Tyrosine

1999
Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination.
    Critical care medicine, 1999, Volume: 27, Issue:9

    Topics: Adolescent; Adult; Aged; Biomarkers; Bronchoalveolar Lavage Fluid; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyl Radical; Hydroxylation; Hypochlorous Acid; Linear Models; Male; Middle Aged; Neutrophil Activation; Neutrophils; Nitrates; Oxidants; Oxidative Stress; Proteins; Respiration, Artificial; Respiratory Distress Syndrome; Statistics, Nonparametric; Tyrosine

1999
Reactions of hypochlorous acid with tyrosine and peptidyl-tyrosyl residues give dichlorinated and aldehydic products in addition to 3-chlorotyrosine.
    The Journal of biological chemistry, 2000, Apr-14, Volume: 275, Issue:15

    Topics: Animals; Humans; Hypochlorous Acid; Lipoproteins, LDL; Mice; Monophenol Monooxygenase; Oxidation-Reduction; Serum Albumin, Bovine; Tyrosine

2000
Nitrite as a substrate and inhibitor of myeloperoxidase. Implications for nitration and hypochlorous acid production at sites of inflammation.
    The Journal of biological chemistry, 2000, Apr-21, Volume: 275, Issue:16

    Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Neutrophils; Nitrites; Oxidation-Reduction; Peroxidase; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet; Tyrosine

2000
Formation of N-nitrosamines and N-nitramines by the reaction of secondary amines with peroxynitrite and other reactive nitrogen species: comparison with nitrotyrosine formation.
    Chemical research in toxicology, 2000, Volume: 13, Issue:4

    Topics: Aniline Compounds; Hydrogen Peroxide; Hypochlorous Acid; Morpholines; Nitrates; Nitrobenzenes; Nitrosamines; Sodium Nitrite; Superoxides; Tyrosine

2000
Comparison of mono- and dichlorinated tyrosines with carbonyls for detection of hypochlorous acid modified proteins.
    Archives of biochemistry and biophysics, 2000, May-01, Volume: 377, Issue:1

    Topics: Animals; Antibodies; Antibody Specificity; Bromates; Carbonic Acid; Cattle; Chlorine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epitopes; Hypochlorous Acid; Inflammation; Mass Spectrometry; Oxidants; Oxidative Stress; Serum Albumin; Tyrosine

2000
Inflammatory properties of IgG modified by oxygen radicals and peroxynitrite.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Dec-01, Volume: 165, Issue:11

    Topics: Acute Disease; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Binding Sites, Antibody; Complement C1q; Complement C3; Female; Free Radicals; Gout; Humans; Hydrogen Peroxide; Hypochlorous Acid; Immunoglobulin G; Male; Neutrophils; Nitrates; Osteoarthritis; Oxidation-Reduction; Oxygen; Rabbits; Receptors, IgG; Serum Albumin, Bovine; Synovial Fluid; Tyrosine

2000
p-Hydroxyphenylacetaldehyde, the major product of tyrosine oxidation by the activated myeloperoxidase system can act as an antioxidant in LDL.
    FEBS letters, 2001, Feb-09, Volume: 490, Issue:1-2

    Topics: Acetaldehyde; Antioxidants; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Endothelium, Vascular; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; Hypochlorous Acid; Ions; Lipid Metabolism; Lipoproteins, LDL; Neutrophils; Oxygen; Peroxidase; Phenol; Protein Binding; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine; Umbilical Veins

2001
Increased atherosclerosis in myeloperoxidase-deficient mice.
    The Journal of clinical investigation, 2001, Volume: 107, Issue:4

    Topics: Animals; Arteriosclerosis; Candida albicans; Humans; Hypochlorous Acid; Mice; Mice, Inbred C57BL; Neutrophils; Oxidation-Reduction; Peroxidase; Phagocytes; Tyrosine

2001
Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin.
    Free radical research, 2001, Volume: 34, Issue:2

    Topics: Amidines; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Erythrocyte Membrane; Erythrocytes; Hemolysis; Humans; Hydrogen Peroxide; Hypochlorous Acid; Interferon-gamma; Lipid Peroxidation; Macrophages; Neopterin; Oxidation-Reduction; Pteridines; Swine; Tyrosine

2001
alpha(2)-Macroglobulin from rheumatoid arthritis synovial fluid: functional analysis defines a role for oxidation in inflammation.
    Archives of biochemistry and biophysics, 2001, Jul-01, Volume: 391, Issue:1

    Topics: alpha-Macroglobulins; Arthritis, Rheumatoid; Humans; Hypochlorous Acid; Mass Spectrometry; Osteoarthritis; Oxidation-Reduction; Peptide Hydrolases; Synovial Fluid; Tyrosine

2001
Chlorination of N-acetyltyrosine with HOCl, chloramines, and myeloperoxidase-hydrogen peroxide-chloride system.
    Acta biochimica Polonica, 2001, Volume: 48, Issue:1

    Topics: Chloramines; Chlorides; Chlorine; Chromatography, High Pressure Liquid; Granulocytes; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hypochlorous Acid; Peroxidase; Protein Binding; Time Factors; Tyrosine

2001
15N chemically induced dynamic nuclear polarization during reaction of N-acetyl-L-tyrosine with the nitrating systems nitrite/hydrogen peroxide/horseradish peroxidase and nitrite/hypochloric acid.
    Archives of biochemistry and biophysics, 2001, Sep-15, Volume: 393, Issue:2

    Topics: Animals; Cattle; Horseradish Peroxidase; Hydrogen Peroxide; Hypochlorous Acid; Magnetic Resonance Spectroscopy; Nitrites; Nitrogen Isotopes; Serum Albumin, Bovine; Tyrosine

2001
Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Oct-09, Volume: 98, Issue:21

    Topics: Animals; Bromine; Chlorine; Disease Models, Animal; HL-60 Cells; Humans; Hypochlorous Acid; Ions; Klebsiella Infections; Klebsiella pneumoniae; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Oxidants; Peroxidase; Sepsis; Tyrosine

2001
Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment.
    Free radical biology & medicine, 2001, Nov-01, Volume: 31, Issue:9

    Topics: Actin Cytoskeleton; Actins; Animals; Biomarkers; Carbonic Acid; Cross-Linking Reagents; Cysteine; Fluorometry; Hypochlorous Acid; In Vitro Techniques; Methionine; Muscle, Skeletal; Oxidation-Reduction; Rabbits; Tyrosine

2001
Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus.
    The Journal of biological chemistry, 2002, Mar-22, Volume: 277, Issue:12

    Topics: Anti-Bacterial Agents; Chlorine; Chromatography, Gas; Dose-Response Relationship, Drug; Hypochlorous Acid; Mass Spectrometry; Neutrophils; Oxidants; Peroxidase; Phagocytosis; Protein Binding; Protein Structure, Tertiary; Staphylococcus aureus; Temperature; Time Factors; Tyrosine

2002
The role of advanced oxidation protein products in regulation of dendritic cell function.
    Free radical biology & medicine, 2002, Mar-01, Volume: 32, Issue:5

    Topics: Animals; Antigens, CD; Cattle; Cell Differentiation; Cell Division; Cells, Cultured; Dendritic Cells; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Hypochlorous Acid; Immunomagnetic Separation; In Vitro Techniques; Interleukin-4; Lipopolysaccharides; Monocytes; Oxidation-Reduction; Reactive Oxygen Species; Serum Albumin, Bovine; T-Lymphocytes; Tyrosine

2002
Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis.
    The Journal of biological chemistry, 2002, Aug-23, Volume: 277, Issue:34

    Topics: Bacterial Proteins; Chlorides; Humans; Hydrogen Peroxide; Hypochlorous Acid; Neutrophils; Nitrites; Peroxidase; Phagocytosis; Tyrosine

2002
Hypochlorous acid activates tyrosine phosphorylation signal pathways leading to calcium signaling and TNFalpha production.
    Antioxidants & redox signaling, 2002, Volume: 4, Issue:3

    Topics: Calcium Signaling; Cytokines; Enzyme Activation; Enzyme Inhibitors; Humans; Hypochlorous Acid; Lymphocytes; Oxidants; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; ZAP-70 Protein-Tyrosine Kinase

2002
Lack of tyrosine nitration by hypochlorous acid in the presence of physiological concentrations of nitrite. Implications for the role of nitryl chloride in tyrosine nitration in vivo.
    The Journal of biological chemistry, 2003, Mar-07, Volume: 278, Issue:10

    Topics: Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Hypochlorous Acid; Immunohistochemistry; Microscopy, Confocal; Nitrates; Nitrites; Tumor Cells, Cultured; Tyrosine

2003
Inhibition of human surfactant protein A function by oxidation intermediates of nitrite.
    Free radical biology & medicine, 2002, Dec-15, Volume: 33, Issue:12

    Topics: Bronchoalveolar Lavage Fluid; Humans; Hydrogen Peroxide; Hypochlorous Acid; Mannose; Nitrates; Nitrites; Oxidation-Reduction; Protein Binding; Pulmonary Surfactant-Associated Protein A; Tyrosine

2002
Oxidation of Cu, Zn-superoxide dismutase by the myeloperoxidase/hydrogen peroxide/chloride system: functional and structural effects.
    Free radical research, 2002, Volume: 36, Issue:11

    Topics: Animals; Cattle; Copper; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Hydrazines; Hydrogen Peroxide; Hypochlorous Acid; Isoelectric Focusing; Lysine; Methionine; Oxidation-Reduction; Peroxidase; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Tyrosine; Zinc

2002
Collagen type II modification by hypochlorite.
    Acta biochimica Polonica, 2003, Volume: 50, Issue:2

    Topics: Amino Acids; Animals; Antigen-Antibody Complex; Cartilage; Chickens; Chlorine; Circular Dichroism; Collagen Type II; Enzyme-Linked Immunosorbent Assay; Hypochlorous Acid; Inflammation Mediators; Oxidation-Reduction; Protein Structure, Secondary; Quaternary Ammonium Compounds; Taurine; Tyrosine

2003
Lysine residues direct the chlorination of tyrosines in YXXK motifs of apolipoprotein A-I when hypochlorous acid oxidizes high density lipoprotein.
    The Journal of biological chemistry, 2004, Feb-27, Volume: 279, Issue:9

    Topics: Acetylation; Adult; Amino Acid Sequence; Antioxidants; Apolipoprotein A-I; Chloramines; Chlorine; Chromatography, High Pressure Liquid; Humans; Hypochlorous Acid; Lipoproteins, HDL; Lysine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine

2004
Hypochlorite action on plasma fibronectin promotes its extended conformation in complexes with antibodies.
    Journal of protein chemistry, 2003, Volume: 22, Issue:5

    Topics: Acrylamide; Antibodies; Antigen-Antibody Complex; Chlorine; Enzyme-Linked Immunosorbent Assay; Fibronectins; Fluorescence; Humans; Hypochlorous Acid; Luminescent Measurements; Tryptophan; Tyrosine

2003
Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.
    The Journal of biological chemistry, 2004, Mar-12, Volume: 279, Issue:11

    Topics: Antioxidants; Dose-Response Relationship, Drug; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Hypochlorous Acid; Inhibitory Concentration 50; Isoenzymes; Models, Biological; Models, Chemical; Nitric Oxide; Oxygen; Peroxynitrous Acid; Potassium; Protein Binding; Rhodamines; Sulfur; Thioctic Acid; Tyrosine

2004
Cholesterol, linoleic acid or/and tyrosine yield different spectra of products when oxidized alone or in a mixture: studies in various oxidative systems.
    Free radical research, 2003, Volume: 37, Issue:12

    Topics: Amidines; Biomarkers; Cholesterol; Hypochlorous Acid; Linoleic Acid; Oxidants; Oxidation-Reduction; Reactive Oxygen Species; Tyrosine

2003
Potential role of methionine sulfoxide in the inactivation of the chaperone GroEL by hypochlorous acid (HOCl) and peroxynitrite (ONOO-).
    The Journal of biological chemistry, 2004, May-07, Volume: 279, Issue:19

    Topics: Amino Acid Sequence; Arteriosclerosis; Chaperonin 60; Chromatography; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Hypochlorous Acid; Mass Spectrometry; Methionine; Methionine Sulfoxide Reductases; Molecular Chaperones; Molecular Sequence Data; Oxidants; Oxidoreductases; Oxygen; Peptides; Peroxynitrous Acid; Phagocytes; Protein Binding; Time Factors; Trypsin; Tyrosine

2004
Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines.
    Free radical biology & medicine, 2004, Jun-15, Volume: 36, Issue:12

    Topics: Antioxidants; Ascorbic Acid; Benzothiazoles; Chromatography, High Pressure Liquid; Clusiaceae; DNA Damage; Dose-Response Relationship, Drug; Hypochlorous Acid; Lipid Peroxidation; Lipids; Mass Spectrometry; Medicine, Chinese Traditional; Models, Chemical; Nitrogen; Peroxynitrous Acid; Phenol; Phospholipids; Sulfonic Acids; Superoxides; Tyrosine; Xanthine Oxidase; Xanthones

2004
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Aug-31, Volume: 101, Issue:35

    Topics: Amino Acid Sequence; Apolipoprotein A-I; Arteries; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cholesterol, HDL; Chromatography, Liquid; Humans; Hypochlorous Acid; Mass Spectrometry; Molecular Sequence Data; Peroxidase; Tyrosine

2004
Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c.
    Free radical biology & medicine, 2004, Nov-15, Volume: 37, Issue:10

    Topics: Animals; Cyclic N-Oxides; Cytochromes c; Electron Spin Resonance Spectroscopy; Humans; Hypochlorous Acid; Nitric Oxide; Nitrites; Oxidation-Reduction; Protein Binding; Reactive Oxygen Species; Tyrosine

2004
Comparison of spectrophotometric, HPLC and chemiluminescence methods for 3-nitrotyrosine and peroxynitrite interaction.
    Archives of pharmacal research, 2005, Volume: 28, Issue:3

    Topics: Chromatography, High Pressure Liquid; Hypochlorous Acid; Luminescent Measurements; Peroxynitrous Acid; Spectrophotometry, Ultraviolet; Tyrosine

2005
Kinetic analysis of the role of histidine chloramines in hypochlorous acid mediated protein oxidation.
    Biochemistry, 2005, May-17, Volume: 44, Issue:19

    Topics: Amides; Amines; Aminocaproic Acid; Arginine; Chloramines; Chromatography, High Pressure Liquid; Glycine; Histidine; Hypochlorous Acid; Imidazoles; Kinetics; Lysine; Oligopeptides; Oxidation-Reduction; Protein Conformation; Tyrosine

2005
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-13, Volume: 25, Issue:28

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amyotrophic Lateral Sclerosis; Animals; Brain; Corpus Striatum; Dopamine; Drug Evaluation, Preclinical; Enzyme Induction; Humans; Huntington Disease; Hypochlorous Acid; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine

2005
Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages.
    Free radical research, 2006, Volume: 40, Issue:1

    Topics: Animals; Cell-Free System; Cells, Cultured; Copper; Hypochlorous Acid; Linoleic Acid; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Molsidomine; Oxidative Stress; Tyrosine

2006
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs.
    Free radical research, 2006, Volume: 40, Issue:5

    Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydroxyl Radical; Hypochlorous Acid; Immunohistochemistry; Lung; Male; Masoprocol; Ozone; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Singlet Oxygen; Superoxides; Tyrosine

2006
Evidence for rapid inter- and intramolecular chlorine transfer reactions of histamine and carnosine chloramines: implications for the prevention of hypochlorous-acid-mediated damage.
    Biochemistry, 2006, Jul-04, Volume: 45, Issue:26

    Topics: Biological Transport; Carnitine; Chloramines; Chlorine; Chromatography, High Pressure Liquid; Drug Stability; Histamine; Histidine; Hypochlorous Acid; Kinetics; Mass Spectrometry; Oxidants; Tyrosine

2006
Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:12

    Topics: Animals; Atherosclerosis; Cells, Cultured; Endothelium, Vascular; Female; Humans; Hypochlorous Acid; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxygen; Peroxidase; Peroxynitrous Acid; Phosphoproteins; Superoxides; Tyrosine; Uncoupling Agents

2006
An exogenous marker: a novel approach for the characterization of oxidative stress.
    Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11

    Topics: Biomarkers; Copper; Deoxyguanosine; Hypochlorous Acid; Linoleic Acid; Linoleic Acids; Molecular Probes; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Tyrosine

2007
The metabolism and dechlorination of chlorotyrosine in vivo.
    The Journal of biological chemistry, 2007, Oct-05, Volume: 282, Issue:40

    Topics: Albumins; Animals; Catalysis; Chlorine; Gas Chromatography-Mass Spectrometry; Hypochlorous Acid; Inflammation; Male; Monocytes; Mutation; Peroxidase; Proteins; Rats; Rats, Sprague-Dawley; Tyrosine

2007
Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo.
    Biochemical and biophysical research communications, 2008, Jun-20, Volume: 371, Issue:1

    Topics: Animals; Biomarkers; HL-60 Cells; Humans; Hypochlorous Acid; Inflammation; Macrophage Activation; Macrophages; Mice; Neutrophils; Nitrites; Oxidants; Peroxidase; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine

2008
Hypochlorous acid damages histone proteins forming 3-chlorotyrosine and 3,5-dichlorotyrosine.
    Chemical research in toxicology, 2008, Volume: 21, Issue:5

    Topics: Amino Acid Sequence; Chlorine; Histones; Hypochlorous Acid; Mass Spectrometry; Molecular Sequence Data; Tyrosine

2008
Hypochlorous acid is a potent inactivator of human plasminogen at concentrations secreted by activated granulocytes.
    Clinical chemistry and laboratory medicine, 2008, Volume: 46, Issue:10

    Topics: Aryldialkylphosphatase; Cysteine; Granulocytes; Humans; Hypochlorous Acid; Lipoproteins, HDL; Plasminogen; Streptokinase; Tyrosine

2008
Development of novel mass spectrometric methods for identifying HOCl-induced modifications to proteins.
    Proteomics, 2009, Volume: 9, Issue:6

    Topics: 5-Hydroxytryptophan; Amino Acid Sequence; Animals; Hypochlorous Acid; Mass Spectrometry; Molecular Sequence Data; Muramidase; Oxidation-Reduction; Peptides; Protein Processing, Post-Translational; Proteins; Sequence Analysis, Protein; Tyrosine

2009
Methylamine dichloramine may play a role in the process of colorectal disease through architectural and oxidative changes in crypts in mice.
    Life sciences, 2009, Jun-19, Volume: 84, Issue:25-26

    Topics: Aldehydes; Animals; Chloramines; Colon; Colonic Neoplasms; Hemoglobins; Hemolysis; Hydrogen Peroxide; Hypochlorous Acid; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Neutrophil Activation; Oxidation-Reduction; Sheep; Tyrosine

2009
Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13.
    Blood, 2010, Jan-21, Volume: 115, Issue:3

    Topics: ADAM Proteins; ADAMTS13 Protein; Amino Acid Sequence; Catalytic Domain; Cells, Cultured; Humans; Hydrogen Peroxide; Hypochlorous Acid; Methionine; Models, Biological; Neutrophils; Oxidants; Oxidation-Reduction; Peptide Fragments; Protein Multimerization; Protein Processing, Post-Translational; Reactive Oxygen Species; Tyrosine; von Willebrand Factor

2010
Functionally active macrophage-derived myeloperoxidase in the skin of drug-induced toxic epidermal necrolysis.
    Dermatology (Basel, Switzerland), 2010, Volume: 220, Issue:3

    Topics: Adolescent; Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blister; Female; Humans; Hypochlorous Acid; Keratinocytes; Lewis X Antigen; Macrophages; Male; Middle Aged; Peroxidase; Stevens-Johnson Syndrome; Tyrosine

2010
Kinetics of 3-chlorotyrosine formation and loss due to hypochlorous acid and chloramines.
    Chemical research in toxicology, 2011, Mar-21, Volume: 24, Issue:3

    Topics: Biomarkers; Chloramines; Chlorides; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hypochlorous Acid; Kinetics; Spectrophotometry, Ultraviolet; Tyrosine

2011
The free amino acid tyrosine enhances the chlorinating activity of human myeloperoxidase.
    Journal of inorganic biochemistry, 2012, Volume: 106, Issue:1

    Topics: Antioxidants; Cells, Cultured; Halogenation; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hypochlorous Acid; Microscopy, Fluorescence; Neutrophils; Oxidants; Oxidation-Reduction; Peroxidase; Sulfhydryl Compounds; Taurine; Tyrosine

2012
Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions.
    The Journal of biological chemistry, 2012, Feb-24, Volume: 287, Issue:9

    Topics: Apolipoprotein A-I; Atherosclerosis; Halogenation; Humans; Hypochlorous Acid; Lipoproteins, HDL; Nitrogen; Oxidation-Reduction; Oxidative Stress; Peroxidase; Protein Processing, Post-Translational; Tyrosine

2012
Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acid.
    Infection and immunity, 2012, Volume: 80, Issue:7

    Topics: Animals; Anti-Infective Agents; Chlorides; Hemeproteins; Humans; Hydrogen Peroxide; Hypochlorous Acid; Mass Spectrometry; Microbial Viability; Peroxidases; Plasma; Taurine; Tyrosine

2012
Studies of oxidant-induced changes in albumin transport function with a fluorescent probe k-35. Effect of hypochlorite.
    Bulletin of experimental biology and medicine, 2012, Volume: 152, Issue:6

    Topics: Binding Sites; Fluorescent Dyes; Humans; Hypochlorous Acid; Imides; Kinetics; Naphthalenes; Oxidants; Oxidation-Reduction; Protein Binding; Protein Carbonylation; Protein Transport; Serum Albumin; Spectrometry, Fluorescence; Tyrosine

2012
Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid.
    Current pharmaceutical design, 2012, Volume: 18, Issue:38

    Topics: Cell-Free System; DNA Damage; Dose-Response Relationship, Drug; Free Radical Scavengers; Ginsenosides; Hydroxyl Radical; Hypochlorous Acid; Mass Spectrometry; Oxidation-Reduction; Oxidative Stress; Tyrosine

2012
Role of lysine during protein modification by HOCl and HOBr: halogen-transfer agent or sacrificial antioxidant?
    Biochemistry, 2013, Feb-19, Volume: 52, Issue:7

    Topics: Adenylyl Cyclases; Antioxidants; Bromates; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Escherichia coli Proteins; Hypochlorous Acid; Lysine; Periplasmic Binding Proteins; Proteins; Serum Albumin, Bovine; Tandem Mass Spectrometry; Tyrosine

2013
Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:5

    Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Biphenyl Compounds; Breath Tests; Disease Models, Animal; Female; Fibrosis; Hypochlorous Acid; Injections, Intradermal; Irbesartan; Lung; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidants; Pulmonary Fibrosis; Scleroderma, Systemic; Skin; Tetrazoles; Tyrosine

2013
Kinetics of 3-nitrotyrosine modification on exposure to hypochlorous acid.
    Free radical research, 2014, Volume: 48, Issue:11

    Topics: Biomarkers; Chloramines; Chromatography, High Pressure Liquid; Humans; Hypochlorous Acid; Kinetics; Peptide Fragments; Peroxidase; Reactive Nitrogen Species; Tyrosine

2014
A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation.
    Biochimica et biophysica acta, 2015, Volume: 1850, Issue:1

    Topics: Advanced Oxidation Protein Products; Arginine; Blotting, Western; Cross-Linking Reagents; Dose-Response Relationship, Drug; Fibrinogen; Humans; Hypochlorous Acid; Lysine; Molecular Weight; Oxidation-Reduction; Protein Carbonylation; Serum Albumin; Tyrosine

2015
RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.
    Experimental lung research, 2016, Volume: 42, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Disease Models, Animal; Female; Hypochlorous Acid; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Pneumonia; Pulmonary Fibrosis; rho-Associated Kinases; Scleroderma, Systemic; Skin; Smad2 Protein; Smad3 Protein; Tyrosine

2016
Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine.
    Free radical biology & medicine, 2016, Volume: 97

    Topics: Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Halogenation; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Mice; Oxidation-Reduction; Peroxidase; Phenanthridines; Tandem Mass Spectrometry; Tyrosine; Vascular Diseases

2016
Thiol oxidation and di-tyrosine formation in human plasma proteins induced by inflammatory concentrations of hypochlorous acid.
    Journal of proteomics, 2017, 01-30, Volume: 152

    Topics: Apolipoprotein A-I; Biomarkers; Blood Proteins; Blood Specimen Collection; Complement C3; Fibrinogen; Humans; Hypochlorous Acid; Inflammation; Mass Spectrometry; Oxidation-Reduction; Oxidative Stress; Peroxidase; Protein Aggregates; Sulfhydryl Compounds; Tyrosine

2017
Analysis of protein chlorination by mass spectrometry.
    Redox biology, 2019, Volume: 26

    Topics: Animals; Basement Membrane; Complex Mixtures; Fibronectins; Halogenation; Humans; Hypochlorous Acid; Laminin; Mass Spectrometry; Mice; Oxidation-Reduction; Sensitivity and Specificity; Tyrosine

2019
Oxidant-mediated modification and cross-linking of beta-2-microglobulin.
    Free radical biology & medicine, 2022, Volume: 187

    Topics: Chromatography, Liquid; Hypochlorous Acid; Oxidants; Oxidation-Reduction; Protein Conformation; Tyrosine

2022
Influence of plasma halide, pseudohalide and nitrite ions on myeloperoxidase-mediated protein and extracellular matrix damage.
    Free radical biology & medicine, 2022, 08-01, Volume: 188

    Topics: Extracellular Matrix; Humans; Hydrogen Peroxide; Hypochlorous Acid; Methionine; Nitrites; Nitrogen Dioxide; Oxidants; Peroxidase; Tryptophan; Tyrosine

2022