Compounds > hypochlorous acid
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hypochlorous acid and clozapine

hypochlorous acid has been researched along with clozapine in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (70.00)18.2507
2000's3 (30.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, ZC; Uetrecht, JP1
Uetrecht, JP1
Fu, JM; Rakhit, S; Tehim, A; Uetrecht, J; Zahid, N1
Brunet, C; Cazin, JC; Cazin, M; Dine, T; Frimat, B; Gressier, B; Luycky, M; Odou, P1
Gardner, I; MacCrimmon, D; Uetrecht, JP; Zahid, N1
Chin, T; Gardner, I; Leeder, JS; Uetrecht, JP; Zahid, N1
Brunet, C; Cazin, JC; Cazin, M; Dine, T; Frimat, B; Gressier, B; Jegouzo, A; Kouach, M; Luyckx, M1
Gardner, I; Lai, WG; Uetrecht, JP; Zahid, N1
Bruhwyler, J; Liégeois, JF; Uetrecht, J; Zahid, N1
Iverson, S; Uetrecht, JP; Zahid, N1

Reviews

1 review(s) available for hypochlorous acid and clozapine

ArticleYear
Reactive metabolites and agranulocytosis.
    European journal of haematology. Supplementum, 1996, Volume: 60

    Topics: Agranulocytosis; Aminopyrine; Clozapine; Humans; Hypochlorous Acid; Neutrophil Activation

1996

Other Studies

9 other study(ies) available for hypochlorous acid and clozapine

ArticleYear
Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: Antipsychotic Agents; Binding Sites; Clozapine; Free Radicals; Glutathione; Humans; Hypochlorous Acid; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Peroxidase; Reference Values

1995
Structural features associated with reactive metabolite formation in clozapine analogues.
    Chemico-biological interactions, 1997, May-02, Volume: 104, Issue:2-3

    Topics: Agranulocytosis; Antipsychotic Agents; Benzodiazepines; Binding Sites; Chromatography, High Pressure Liquid; Chromatography, Liquid; Clozapine; Dibenzazepines; Glutathione; Granulocytes; Humans; Hydrogen Peroxide; Hypochlorous Acid; Lymphocyte Activation; Mass Spectrometry; Neutrophils; Nitrogen; Olanzapine; Oxidation-Reduction; Peroxidase; Pirenzepine; Structure-Activity Relationship

1997
Metabolism of clozapine by human neutrophils: evidence for a specific oxidation of clozapine by the myeloperoxidase system with inhibition of enzymatic chlorination cycle.
    Fundamental & clinical pharmacology, 1997, Volume: 11, Issue:3

    Topics: Antipsychotic Agents; Cell Survival; Cells, Cultured; Clozapine; Humans; Hydrogen Peroxide; Hypochlorous Acid; Mass Spectrometry; Neutrophils; Oxidation-Reduction; Peroxidase

1997
A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes.
    Molecular pharmacology, 1998, Volume: 53, Issue:6

    Topics: Agranulocytosis; Antipsychotic Agents; Benzodiazepines; Clozapine; HL-60 Cells; Humans; Hypochlorous Acid; Neutrophils; Olanzapine; Oxidation-Reduction; Pirenzepine

1998
A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo.
    Molecular pharmacology, 1998, Volume: 53, Issue:6

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Bone Marrow; Clozapine; Female; Humans; Hypochlorous Acid; Immune Sera; Immunoblotting; Male; Neutrophils; Olanzapine; Peroxidase; Pirenzepine; Rabbits; Rats; Rats, Inbred Lew

1998
Comparative oxidation of loxapine and clozapine by human neutrophils.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:1

    Topics: Antioxidants; Antipsychotic Agents; Cell Survival; Cell-Free System; Clozapine; Glutathione; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Hypochlorous Acid; Loxapine; Mass Spectrometry; Neutrophils; Oxidation-Reduction; Spectrophotometry

1999
Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:3

    Topics: Acetylcysteine; Agranulocytosis; Binding, Competitive; Clozapine; Dibenzazepines; Glutathione; Hemocyanins; Humans; Hypochlorous Acid; Immune Sera; Immunoblotting; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Peroxidase; Protein Binding

2000
Hypochlorous acid, a major oxidant produced by activated neutrophils, has low effect on two pyridobenzazepine derivatives, JL 3 and JL 13.
    Archiv der Pharmazie, 2000, Volume: 333, Issue:2-3

    Topics: Antipsychotic Agents; Clozapine; Humans; Hypochlorous Acid; In Vitro Techniques; Neutrophils; Oxidants; Oxidation-Reduction; Thiazepines

2000
Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis.
    Chemico-biological interactions, 2002, Nov-10, Volume: 142, Issue:1-2

    Topics: Agranulocytosis; Antipsychotic Agents; Apoptosis; Benzodiazepines; Chromatography, High Pressure Liquid; Chromatography, Liquid; Clozapine; Cyanides; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Hypochlorous Acid; Mass Spectrometry; Mianserin; Neutrophils; Nuclear Medicine; Olanzapine; Pirenzepine

2002