hyperoside and 3-methylquercetin

We investigated the chemical constituents of the leaves of Psidum littorale, which include 16 flavonoids, including seven flavonols, six flavonoid glycosides and three flavonones. The compounds were isolated by silica gel column chromatography. Their structures were elucidated on the basis of spectral analysis and by comparison with published data. Seven flavonols were kaempferol (1), isorhamnetin (2), myricetin- 3,7,3’-trimethyl ether(3), laricitrin (4), quercetin (5), myricetin (6) and quercein-3,4’-dimethyl ether (7), six flavonoid glycosides were guaijaverin (8), hyperoside (9), 5,4’-dyhydroxy-3,7,5’-methoxyflavone-3’-O-β-D- glucoside (10), laricitrin-3-O-xyloside (11), myricetin-3-O-α-L-rhamnopyranoside (12) and myricetin-3-O-β-D- xyloside (13). Three flavonones were 4’-O-methyldihydroquercetin (14), dihydroapigenin (15) and ampelopsin 4’-O-β-D-glucopyranoside (16). Compound 10 is a new chemical, compounds 2-4, 7, 10-16 were first isolated from this plant. (1)H NMR and (13)C NMR data of compound 11 were not reported in literature.

Topics: Flavonoids; Flavonols; Glycosides; Kaempferols; Plant Leaves; Psidium; Quercetin

The aqueous and ethanol extracts from the leaves of Gochnatia polymorpha and further fractions obtained from the latter extract using solvents with increasing polarity, including its aqueous residue and the amino acid, 4-hydroxy-N-methyl-proline were investigated by carrageenin-induced pedal oedema formation. It was shown that the aqueous and ethanol extracts and the ethyl acetate fraction demonstrated significant antiinflammatory activity. The chemical investigation of the latter fraction revealed the presence of caffeic acid, chlorogenic acid, 3-0-methylquercetin, hyperosid and rutin. The amino acid 4-hydroxy-N-methyl-proline, a nonprotein amino acid that has not been reported before in the Asteraceae was isolated as a major compound and identified by spectroscopic methods.

Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Antiviral Agents; Brazil; Caffeic Acids; Chlorogenic Acid; Chromatography, Gel; Chromatography, Thin Layer; Edema; Flavonols; Plant Extracts; Plant Leaves; Plants, Medicinal; Proline; Quercetin; Rats; Rutin