hypericin has been researched along with perylene in 873 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (1.49) | 18.7374 |
| 1990's | 125 (14.32) | 18.2507 |
| 2000's | 359 (41.12) | 29.6817 |
| 2010's | 301 (34.48) | 24.3611 |
| 2020's | 75 (8.59) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, TY; Song, PS; Walker, EB | 1 |
| Carter, C; Degar, S; Ehrlich, LS; Lavie, D; Lavie, G; Levin, B; Mazur, Y; Meruelo, D; Pascual, D; Prince, AM | 1 |
| Pardini, RS; Thomas, C | 1 |
| Cotton, TM; Kolaczkowski, SV; Raser, LN | 1 |
| MacGill, RS; Miller, GC; Pardini, RS; Thomas, C | 1 |
| Hudson, JB; Lopez-Bazzocchi, I; Towers, GH | 2 |
| Andersen, DO; Hughes, BG; Murray, BK; North, JA; Weber, ND; Wood, SG | 1 |
| Akinaga, S; Kobayashi, E; Nakano, H; Suzuki, K; Takahashi, I; Tamaoki, T | 1 |
| Colacino, JM; Larsen, SH; Spitzer, W; Tang, J | 1 |
| Carpenter, S; Kraus, GA; Pratt, D; Tossberg, J | 1 |
| Carpenter, S; Kraus, GA | 1 |
| Ghiron, CA; Grossweiner, LI; Longworth, JW; Senthil, V | 1 |
| Freeman, D; Hochster, H; Kudler, N; Lavie, D; Lavie, G; Levin, B; Liebes, L; Mazur, Y; Mendoza, S; Meruelo, D | 1 |
| Lidzba, H; Miltenburger, HG; Okpanyi, SN; Scholl, BC | 1 |
| Gallo, G; Lavie, D; Lavie, G; Levin, B; Mazur, Y; Meruelo, D; Valentine, F; Weiner, D | 1 |
| Kobayashi, E; Nakanishi, S; Nakano, H; Suzuki, K; Takahashi, I; Tamaoki, T | 1 |
| Lavie, D; Lavie, G; Meruelo, D | 1 |
| Durán, N; Song, PS | 1 |
| Bladt, S; Katsumata, Y; Oya, M; Suzuki, O; Wagner, H | 1 |
| Müldner, H; Zöller, M | 1 |
| Araya, OS; Ford, EJ | 1 |
| Chen, ZH; Gopalakrishna, R; Gundimeda, U | 1 |
| Horton, AA; Kanno, T; Kobuchi, H; Nishiuchi, T; Takehara, Y; Utsumi, K; Utsumi, T; Yasuda, T; Yoshioka, T | 1 |
| Carpenter, SL; Fehr, MJ; Petrich, JW; Wannemuehler, Y | 1 |
| Degar, S; Lavie, G; Meruelo, D | 1 |
| Grant, S; Jarvis, WD; Povirk, LF; Traylor, RS; Turner, AJ | 1 |
| Couldwell, WT; Hintona, DR; Lawa, RE; Su, Y; Zhang, W | 1 |
| Diwu, Z | 1 |
| Angelini, N; Cubeddu, R; Ghetti, F; Lenci, F; Losi, A; Pifferi, A; Sgarbossa, A; Taroni, P; Vecli, A; Viappiani, C | 1 |
| Fujita, Y; Horton, AA; Kanno, T; Okuma, M; Takehara, Y; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Lenard, J; Rabson, A; Vanderoef, R | 1 |
| Favier, A; Hadjur, C; Jardon, P; Parat, MO; Richard, MJ | 2 |
| Lavie, D; Lavie, G; Mazur, Y; Meruelo, D | 1 |
| Vyas, GN | 1 |
| Lavie, D; Lavie, G; Levin, B; Liebes, L; Mazur, Y; Meruelo, D; Pascual, D; Prince, AM | 1 |
| Agostinis, P; De Witte, P; Donella-Deana, A; Goris, J; Lee, KT; Merlevede, W; Pinna, LA; Vandenbogaerde, A; Vandenheede, JR | 1 |
| Apuzzo, ML; Couldwell, WT; Gopalakrishna, R; He, S; Hinton, DR; Law, RE; Weiss, MH | 1 |
| Horton, AA; Kanno, T; Kobuchi, H; Okuma, M; Utsumi, K; Utsumi, T; Yasuda, T | 1 |
| Jobert, M; Schulz, H | 1 |
| Brockmöller, J; Kerb, R; Ploch, M; Roots, I; Staffeldt, B | 2 |
| Thiede, HM; Walper, A | 1 |
| Bladt, S; Wagner, H | 1 |
| Graham, EA; Hudson, JB; Towers, GH | 1 |
| Chen, J; Harris, L; Hudson, JB; Towers, GH; Yip, L; Zhou, J | 1 |
| Castro, DJ; Chung, PS; Foote, C; Mathey, A; Paiva, MB; Rhee, CK; Saxton, RE; Soudant, J | 1 |
| Carpenter, S; Fehr, MJ; Kraus, GA; Petrich, JW | 1 |
| Andreoni, A; Colasanti, A; Colasanti, P; Mastrocinque, M; Riccio, P; Roberti, G | 1 |
| Grossweiner, LI; Jones, LR; Senthil, K; Senthil, V | 1 |
| al-Sultan, II; Kako, MD; Saleem, AN | 1 |
| Redepenning, J; Tao, N | 1 |
| Agostinis, P; de Witte, P; Merlevede, W; Van Lint, J; Vandenheede, JR | 1 |
| Angerhofer, A; Falk, H; Meyer, J; Schoppel, G | 1 |
| Lenard, J; Stevenson, NR | 1 |
| Diwu, Z; Lown, JW | 1 |
| Harris, L; Hudson, JB; Towers, GH | 1 |
| Aldrich, CE; Colacino, JM; Condreay, LD; Jilbert, AR; Larsen, SH; Mason, WS; Moraleda, G; Tang, JC; Wu, TT | 1 |
| Chinsky, L; Miskovsky, P; Sureau, F; Turpin, PY | 1 |
| Agostinis, P; Cuveele, J; de Witte, P; Donella-Deana, A; Merlevede, W; Sarno, S; Vandenbogaerde, A | 1 |
| Cohen, PA; Hudson, JB; Towers, GH | 1 |
| Anderson, J; Castro, DJ; Chang, A; Foote, C; Horton, D; Mathey, A; Paiva, MB; Saxton, RE; Soudant, J; VanderWerf, QM | 1 |
| Currò, P; Lanuzza, F; Micali, G | 1 |
| Gopalakrishna, R; Gundimeda, U; Harris, MS; He, S; Hinton, DR; Kimura, H; Ryan, SJ; Sakamoto, T; Spee, C; Yoo, JS | 1 |
| de Witte, P; Donnella-Deana, A; Samel, D | 1 |
| Göbel, I; Heydel, B; Kartnig, T | 1 |
| Chen, ZH; Couldwell, WT; Gopalakrishna, R; Hamilton, HB; Hinton, DR; Law, RE; Su, YZ; Weiss, MH | 1 |
| Kegode, R; Osweller, GD; Wolford, ST; Yu, H; Zhao, W | 1 |
| al-Akhras, MA; Grossweiner, LI | 1 |
| Chinsky, L; Miskovsky, P; Turpin, PY; Wheeler, GV | 1 |
| Couldwell, WT; Hinton, DR; Surnock, AA; Zhang, W | 1 |
| Davies, DE; Richter, A | 1 |
| Alth, G; Ebermann, R; Jessner, G; Jindra, R; Kubin, A | 1 |
| Alth, G; Ebermann, R; Jindra, RH; Koderhold, G; Koren, H; Kreitner, M; Kubin, A; Schenk, GM | 1 |
| Cuveele, JF; de Witte, PA; Himpens, BE; Merlevede, WJ; Proot, P; Vandenbogaerde, AL | 1 |
| Baureithel, KH; Burkard, W; Büter, KB; Engesser, A; Schaffner, W | 1 |
| Lotz, R; Piperopoulos, G; Schmierer, T; Wixforth, A; Zeller, KP | 1 |
| Bremen, D; Grimmel, C; Krajewski, S; Reed, JC; Schabet, M; Trepel, M; Weller, M | 1 |
| Cui, JZ; Gopalakrishna, R; Gundimeda, U; Harris, MS; Hinton, DR; Kimura, H; Ryan, SJ; Sakamoto, T; Spee, C | 1 |
| Bauer, S; Brockmöller, J; Hübner, WD; Kerb, R; Reum, T; Roots, I | 1 |
| Hoelzl, J; Lehr, CM; Sattler, S; Schaefer, U; Schneider, W | 1 |
| Arshadnia, S; Castro, DJ; Eshraghi, AA; Graeber, IP; Jongewaard, N; Lamas, G; Paiva, MB; Saxton, RE; Soudant, J | 1 |
| de Witte, PA; Delaey, EM; Himpens, BE; Merlevede, WJ; Vandenbogaerde, AL; Vantieghem, AM | 1 |
| Couldwell, WT; Hinton, DR; Law, RE; Zhang, W | 1 |
| Raffa, RB | 1 |
| Johnson, SA; Pardini, RS | 1 |
| Butterweck, V; Nahrstedt, A; Petereit, F; Winterhoff, H | 1 |
| Dalton, AE; Johnson, SA; Pardini, RS | 1 |
| Chinsky, L; Kocisova, E; Miskovsky, P | 2 |
| Dimpfel, W; Sauer, S; Schellenberg, R | 1 |
| Fox, FE; Niu, Z; Rook, AH; Tobia, A | 1 |
| Cott, JM; Fugh-Berman, A | 1 |
| Anderson, JL; Ehrenberg, B; Foote, CS | 1 |
| Bushman, F; Farnet, CM; Hansen, M; Lipford, JR; Robinson, WE; Siegel, J; Wang, B; Zalkow, L | 1 |
| Carpenter, S; English, DS; Park, J; Petrich, JW; Wannemuehler, Y | 1 |
| Anker, L; Couldwell, WT; Gopalakrishna, R; Gundimeda, U; Hinton, DR; Law, RE; Pu, Q; Weiss, MH; Zhang, W | 1 |
| Agostinis, P; Assefa, Z; Courtois, S; de Witte, P; Declercq, W; Merlevede, W; Vandenabeele, P; Vandenheede, JR; Vantieghem, A | 1 |
| Beurdeley-Thomas, A; De Pinieux, G; Dutrillaux, B; Miccoli, L; Oudard, S; Poupon, MF; Sureau, F | 1 |
| de Witte, PA; Delaey, E; Himpens, BE; Kamuhabwa, A; Merlevede, WJ; Vandenbogaerde, AL | 1 |
| Choi, SK; Kim, JI; Lee, KT; Park, HJ; Park, JH | 1 |
| Heine, A; Schempp, CM; Schöpf, E; Simon, JC; Simon-Haarhaus, B | 1 |
| Aizman, I; Kaplinsky, C; Lavie, G; Mandel, M; Mazur, Y; Meruelo, D; Toren, A | 1 |
| Crumpacker, C; Forcht, J; Gulick, RM; Holden-Wiltse, J; Hussey, S; Liebes, L; McAuliffe, V; Meehan, P; Stein, DS; Valentine, FT | 1 |
| Elstner, EF; Hippeli, S; Kleber, E; Obry, T; Schneider, W | 1 |
| Denke, A; Elstner, EF; Schneider, W | 1 |
| Denke, A; Elstner, EF; Mann, E; Schempp, H; Schneider, W | 1 |
| Agostinis, P; Assefa, Z; de Witte, P; Declercq, W; Merlevede, W; Vandenabeele, P; Vandenheede, JR; Vantieghem, A | 1 |
| Agostinis, P; De Witte, PA; Delaey, EM; Vandenbogaerde, AL | 1 |
| Doyle, RT; English, DS; Haydon, PG; Petrich, JW | 1 |
| Chi, JD; Franklin, M | 1 |
| Chaloupka, R; Obsil, T; Plásek, J; Sureau, F | 1 |
| Bacher, S; Bork, PM; Heinrich, M; Kaspers, U; Schmitz, ML | 1 |
| Das, K; Miskovsky, P; Petrich, JW; Smirnov, AV; Wen, J | 1 |
| Calapai, G; Campo, GM; Caputi, AP; Costantino, G; Crupi, A; Firenzuoli, F; Inferrera, G | 1 |
| Campling, G; Chi, J; Cowen, PJ; Franklin, M; Hockney, R; McGavin, C; Reed, A; Whale, RW | 1 |
| Mazur, Y; Roth, E; Silman, I; Weiner, L | 1 |
| Fiebich, BL; Heinrich, M; Kammerer, N; Langosch, JM; Lieb, K | 1 |
| Hinton, DR; Inomata, HR; Ishibashi, TR; Murata, TR; Oshima, YR; Ryan, SJ; Sakamoto, TR; Tahara, YR | 1 |
| Brendler-Schwaab, SY; Kasper, P; Kersten, B; Müller, L; Zhang, J | 1 |
| Augustijns, P; de Witte, PA; Kamuhabwa, AR | 1 |
| Kocisová, E; Mirossay, A; Mirossay, L; Miskovský, P; Mojzis, J; Radváková, I | 1 |
| de Witte, PA; Delaey, E; Hudson, JB | 1 |
| Chaloupka, R; Israël, N; Petit, PX; Sureau, F | 1 |
| de Witte, PA; Delaey, EM; Kamuhabwa, AR; Vandenbogaerde, AL | 1 |
| Carpenter, S; Kraus, GA; Melekhov, A; Petrich, J; Wannemuhler, Y | 1 |
| de Moor, A; De Witte, P; Martens, A; Merlevede, W; Waelkens, E | 1 |
| Dubovi, E; Lavie, G; Liebes, L; Mandel, M; Mazur, Y; Meruelo, D; Pascual, D; Prince, AM | 1 |
| Charchoglyan, A; Hayashi, H; Inoue, K; Kirakosyan, A; Vardapetyan, H | 1 |
| Aroyo, K; Lavie, G; Mandel, M; Meruelo, D | 1 |
| Chang, SG; Jung, JC; Kim, JI; Lee, KT; Miyamoto, K; Park, HJ; Park, JH; Rho, YS | 1 |
| Chen, B; de Witte, PA | 1 |
| Baraldi, M; De Witte, P; Kamuhabwa, A; Merlevede, W; Puia, G; Truzzi, C; Vandenbogaerde, A; Zanoli, P | 1 |
| Giese, A; Puchner, MJ | 1 |
| Berencsi, K; Geng, Y; Gonczol, E; Margolis, DJ; Rook, AH; Shane, RB; Trinchieri, G; Zaki, MH | 1 |
| Agostinis, P; Assefa, Z; De Witte, P; Merlevede, W; Vandenheede, JR; Vantieghem, A | 1 |
| Colasanti, A; Kisslinger, A; Liuzzi, R; Quarto, M; Riccio, P; Roberti, G; Tramontano, D; Villani, F | 1 |
| Denke, A; Elstner, EF; Schempp, H; Weiser, D | 1 |
| de Witte, PA; Geboes, KR; Kamuhabwa, AR | 1 |
| Obach, RS | 1 |
| Lüdtke, R; Schempp, CM; Simon, JC; Winghofer, B | 1 |
| Baert, L; D'Hallewin, MA; De Witte, PA; Merlevede, W; Waelkens, E | 1 |
| Castro, DJ; Chung, J; Chung, PS; Eshraghi, AA; Kim, KH; Paek, W; Paiva, MB; Rhee, CK; Saxton, RE | 1 |
| Kwan, D; Liu, CD; McFadden, DW; Saxton, RE | 1 |
| Chignell, CF; Datillo, M; Patat, S; Roberts, JE; Schey, KL; Wang, RH | 1 |
| Agostini, M; Chatterjee, VK; Love, J; Schwabe, JW; Wentworth, JM | 1 |
| Carnat, A; Carnat, AP; Fraisse, D; Girzu-Amblard, M; Lamaison, JL | 1 |
| de Witte, P; Delaey, E; Merlevede, W; Vandenbogaerde, A | 1 |
| Ashby, KD; Chowdhury, PK; Datta, A; Petrich, JW | 1 |
| Draves, AH; Walker, SE | 2 |
| Angelini, N; Gioffré, D; Lenci, F; Roberts, JE; Sgarbossa, A; Youssef, T | 1 |
| Ehrenberg, B; Freeman, D; Mazur, Y; Roslaniec, M; Weitman, H | 1 |
| Cabana, BE; Feinman, L; Jacobson, JM; Koslowski, V; Lee, D; Liebes, L; Ostrow, N; Prince, AM; Spritzler, J; Tobia, A | 1 |
| Hovhannisyan, V; Theodossiou, T; Yova, D | 1 |
| Agrosi, M; Harrasser, PC; Mischiatti, S; Savio, D | 1 |
| Hájiková, M; Lacková, A; Mirossay, A; Mirossay, L; Mojzis, J; Tóthová, J | 1 |
| Chi, JD; Cowen, PJ; Franklin, M; Mannel, M | 1 |
| Meier, B; Sticher, O; Wirz, A | 2 |
| Adamson, PC; Fox, E; McCully, CL; Murphy, RF | 1 |
| Chen, B; de Witte, PA; Zupkó, I | 1 |
| Bourke, CA; Southwell, IA | 1 |
| Chowdhury, PK; Datta, A; Park, J; Petrich, JW | 1 |
| Afri, M; Ehrenberg, B; Freeman, D; Frimer, AA; Mazur, Y; Roslaniec, M; Weitman, H | 1 |
| Schempp, CM; Simon, JC; Simon-Haarhaus, B; Termeer, CC | 1 |
| Baert, L; D'Hallewin, MA; De Witte, PA; Kamuhabwa, AR; Zupkó, I | 1 |
| Müller, K; Schempp, CM; Schulte-Mönting, J; Simon, JC; Winghofer, B | 1 |
| Schulz, V | 1 |
| Kanofsky, JR; Sima, PD | 1 |
| Di Gregorio, F; Girardin, P; Poutaraud, A; Tin, VC | 1 |
| Agostinis, P; Chen, B; De Witte, PA; Xu, Y | 1 |
| Kuhn, D | 1 |
| Cerman, J; Mareková, M; Vávrová, J; Vokurková, D | 1 |
| Brackett, BG; Dinkins, MB; Howerth, EW; Stallknecht, DE | 1 |
| Agostinis, P; Chen, B; de Witte, P; Delaey, E; Roskams, T; Vandenheede, JR; Xu, Y | 1 |
| Hunt, EJ; Lester, CE; Lester, EA; Tackett, RL | 1 |
| Crescenzi, E; Paba, V; Palumbo, G; Quarto, M; Varriale, L | 1 |
| Chatterjee, S; Nöldner, M | 1 |
| Müller, WE; Siebert, B; Singer, A; Wonnemann, M | 1 |
| Baumeister, A; Dressman, J; Kaunzinger, A; Schubert-Zsilovecz, M; Westerhoff, K; Wilke, A; Wurglics, M | 1 |
| Butterweck, V; Korte, B; Winterhoff, H | 1 |
| Cowen, PJ; Franklin, M | 1 |
| Gobbi, M; Mennini, T; Moia, M; Morizzoni, P; Pirona, L | 1 |
| Calapai, G; Caputi, AP; Ciliberto, G; Crupi, A; De Sarro, G; Firenzuoli, F; Inferrera, G; Parisi, A | 1 |
| Butterweck, V; Herkenham, M; Winterhoff, H | 1 |
| Blank, M; Hazan, S; Keisari, Y; Lavie, G; Mandel, M | 1 |
| Agostinis, PM; Baert, L; D'Hallewin, MA; de Witte, PA; Kamuhabwa, AR | 1 |
| Agostinis, P; de Witte, PA; Declercq, W; Denecker, G; Merlevede, W; Vandenabeele, P; Vandenheede, JR; Vantieghem, A; Xu, Y | 1 |
| Barbosa, F; Freeman, D; Fridkin, M; Gescheidt, G; Mazur, Y; Palivan, C; Rahimipour, S; Weiner, L | 1 |
| Bandyopadhyay, P; Choudhury, PK; Chowdhury, PK; Datta, A; Gordon, MS; Kesavan, S; Kraus, GA; Park, J; Petrich, JW; Showalter, BM; Toscano, JP; Zeng, Y | 1 |
| De Vos, D; de Witte, PA; Delaey, EM; Falk, H; Obermuëller, R; Zupkó, I | 1 |
| Chinsky, L; Fabriciova, G; Hritz, J; Miskovsky, P; Sanchez-Cortes, S; Ulicny, J | 1 |
| Lenci, F; Sgarbossa, A | 1 |
| Freeman, D; Konstantinovskii, L; Mazur, Y | 1 |
| Falk, H; Hohenthanner, K; Obermüller, RA | 1 |
| Carpenter, S; Kesavan, S; Kraus, GA; Park, J; Petrich, JW; Wen, J; Wills, NJ | 1 |
| Guns, ES; Hudson, JB; Xie, X | 1 |
| Bergonzi, MC; Bilia, AR; Gallori, S; Guerrini, D; Vincieri, FF | 1 |
| Taylor, D; Werneke, U; Whiskey, E | 1 |
| Baker, RK; Kroll, DJ; Kurz, EU; Peebles, KA; Schneider, BJ | 1 |
| de los Reyes, GC; Koda, RT | 2 |
| Coutts, RT; Gu, LD; Ling, L; Pang, PK; Shan, JJ; Sloley, BD; Urichuk, LJ | 1 |
| Ali, SM; Chee, SK; Olivo, M; Yuen, GY | 4 |
| Hansen, SH; Jensen, AG | 1 |
| Brezáni, P; Cavarga, I; Cekanová-Figurová, M; Fedorocko, P; Miskovský, P; Solár, P | 1 |
| Blank, M; Keisari, Y; Lavie, G; Mandel, M | 1 |
| Hjortland, GO; Iani, V; Ma, LW; Moan, J; Steen, HB; Uzdensky, AB | 1 |
| Chan, LY; Chiu, PY; Lau, TK | 1 |
| Greenblatt, DJ; Perloff, MD; Shader, RI; Störmer, E; von Moltke, LL | 1 |
| De Witte, PA; Derycke, AS | 1 |
| Kiniczky, M | 1 |
| Baert, L; Cosserat-Gerardin, I; D'Hallewin, MA; de Witte, PA; Didelon, J; Guillemin, F; Kamuhabwa, AA; Notter, D; Roskams, T | 1 |
| Mrlianová, M; Tekel'ová, D | 1 |
| Bauer, S; Graubaum, HJ; Roots, I; Störmer, E | 1 |
| Mirossay, A; Mirossay, L; Mojzis, J; Onderková, H; Sarisský, M | 1 |
| Pytel, A; Schmeller, N | 1 |
| Agostinis, P; de Witte, PA; Merlevede, W; Vantieghem, A | 1 |
| Coppola, E; Palumbo, G; Quarto, M; Varriale, L; Veneziani, BM | 1 |
| Agostinis, P; Chen, B; de Witte, PA; Roskams, T; Xu, Y | 1 |
| Schempp, CM; Simon, JC; Simon-Haarhaus, B | 1 |
| Böckers, T; Butterweck, V; Korte, B; Winterhoff, H; Wittkowski, W | 1 |
| Bray, BJ; Brennan, NJ; Menkes, DB; Perry, NB; Rosengren, RJ | 1 |
| Miskovsky, P | 1 |
| Djordjevic, S; Laatsch, H; Lepojevic, Z; Smelcerovic, A | 1 |
| Chen, H; Chen, X; Zhang, Z; Zhao, J | 1 |
| Mirossay, A; Mirossay, L; Miskovský, P; Mojzis, J; Onderková, H; Tóthová, J | 1 |
| Baert, L; D'Hallewin, MA; De Witte, PA; Kamuhabwa, AR; Roskams, T | 1 |
| Cotterill, JA | 1 |
| Hritz, J; Kascakova, S; Miskovsky, P; Ulicny, J | 1 |
| Pal Bais, H; Vivanco, JM; Walker, TS | 1 |
| Bay, BH; Du, H; Mahendran, R; Olivo, M | 3 |
| Agostinis, P; Assefa, Z; De Witte, PA; Merlevede, W; Piette, J; Vandenheede, JR; Vantieghem, A; Xu, Y | 1 |
| Bon, C; Roth, E; Shin, I; Silman, I; Wachtel, E; Weiner, L | 1 |
| Brezáni, P; Cavarga, I; Cekanová-Figurová, M; Fedorocko, P; Hofmanová, J; Hrcková, G; Kozubík, A; Miskovský, P; Solár, P | 1 |
| Ali, SM; Olivo, M | 1 |
| Carpenter, S; Chowdhury, P; Kesavan, S; Kraus, GA; Park, J; Petrich, JW; Wannemuehler, Y; Wen, J; Wills, NJ | 1 |
| Romerio, F; Zella, D | 1 |
| Gertsch, J; Güttinger, M; Heilmann, J; Sticher, O | 1 |
| Bonn, GK; Huck, CW; Pirker, R | 1 |
| Iani, V; Ma, LW; Moan, J; Uzdensky, AB | 1 |
| Blank, M; Keisari, Y; Kimel, S; Kostenich, G; Lavie, G; Orenstein, A | 1 |
| Bezdetnaya, L; D'Hallewin, MA; Guillemin, F | 1 |
| Chen, B; de Witte, PA; Roskams, T | 1 |
| Murch, SJ; Rupasinghe, HP; Saxena, PK | 1 |
| Berger Büter, K; Bobirnac, I; Lübbert, H; Schaffner, W; Schoeffter, P; Simmen, U; Ullmer, C | 1 |
| Mirossay, A; Mirossay, L; Mojzis, J; Papp, P; Sarisský, M | 1 |
| Abourashed, EA; Glisson, JK; Hufford, CD; Khan, I; Ogletree, R; Rogers, HE | 1 |
| Gao, Q; Hui, Y; Wang, L; Wang, Y | 1 |
| Schmitt, J | 1 |
| Heinrich, M; Kaltschmidt, B; Kaltschmidt, C | 1 |
| Baert, L; De Witte, PA; Kamuhabwa, AA; Roskams, T | 1 |
| Ehrenberg, B; Freeman, D; Malik, Z; Mazur, Y; Siboni, G; Weitman, H | 1 |
| Ingendoh, A; Kiehne, A; Piperopoulos, G; Zeller, KP | 1 |
| Hershey, CM; Lammering, GM; Taher, MM; Valerie, KC | 1 |
| Höpfner, M; Kashtan, H; Lenz, M; Maaser, K; Riecken, EO; Scherübl, H; Sutter, AP; Theiss, A; von Lampe, B; Zeitz, M | 1 |
| Butterweck, V; Liefländer-Wulf, U; Nahrstedt, A; Winterhoff, H | 1 |
| Bay, BH; Du, HY; Olivo, M | 2 |
| Jürgenliemk, G; Nahrstedt, A | 1 |
| Chen, TC; Fry, D; Liebes, L; Su, S | 1 |
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| Fedoročko, P; Ghantous, A; Halaburková, A; Herceg, Z; Jendželovský, R; Kovaľ, J | 1 |
| Alev, M; Alexiou, C; Friedrich, RP; Janko, C; Mühleisen, L; Pöttler, M; Subatzus, D; Unterweger, H | 1 |
| Baesso, ML; Borghi-Pangoni, FB; Bruschi, ML; Caetano, W; de Castro, LV; de Souza Ferreira, SB; Diniz, A; Junqueira, MV; Rabello, BR; Silva, LL | 1 |
| de Oliveira, KT; Moritz, MNO; Perussi, JR; Rossa, C; Uliana, MP | 1 |
| Ameloot, M; Deville, S; Ethirajan, A; Haji Maghsoudi, O; Notelaers, K; Penjweini, R | 1 |
| Bálintová, M; Čellárová, E; Henzelyová, J; Kusari, S; Nigutová, K; Petijová, L; Sezgin, S; Spiteller, M | 1 |
| Dehez, F; Gattuso, H; Marazzi, M; Monari, A | 1 |
| Cerchiaro, G; de Andrade, GP; Manieri, TM; Nunes, EA; Ribeiro, AO; Viana, GM | 1 |
| Garcia, CP; Lopera, AA; Montoya, A; Robledo, SM; Vélez, ID | 1 |
| Aghazadeh, M; Khadem Nezhad, S; Samadi Kafil, H; Taghavi Zenouz, A | 1 |
| Antalík, M; Jancura, D; Keša, P; Kudláčová, J; Valušová, E | 1 |
| Cabrele, C; Krammer, B; Roschger, C; Verwanger, T | 1 |
| Kim, HA; Kim, HJ; Kook, JH; You, MK | 1 |
| Barbosa, PM; Bruschi, ML; Caetano, W; César, GB; Gonçalves, RS; Hioka, N; Nakamura, CV | 1 |
| Cao, H; Cui, X; Guo, H; Han, C; Li, Y; Wang, S; Xi, X; Xu, F; Zheng, M | 1 |
| Dresler, S; Kováčik, J; Sowa, I; Strzemski, M; Wójciak-Kosior, M | 1 |
| Bruňáková, K; Čellárová, E; Kimáková, K; Petijová, L | 1 |
| Abdullah, RK; Dalmizrak, O; Ozer, N; Teralı, K | 1 |
| Čulka, Ľ; Fedoročko, P; Fedr, R; Jendželovský, R; Kozubík, A; Kuchárová, B; Mikeš, J; Mikešová, L; Remšík, J; Souček, K; Vargová, J | 1 |
| Bezzon, VDN; Clementino, LC; de Freitas, LM; Fontana, CR; Garcia, C; Graminha, MAS; Lopera, AA; Montoya, A; Robledo, S; Velásquez, AMA | 1 |
| Franzese, O; Marini, M; Rinaldi, A; Roscetti, G; Valletta, E | 1 |
| Chang, NS; Chen, SJ; Dong, CY; Hovhannisyan, VA; Lai, FJ | 1 |
| Hou, M; Li, YY; Li, ZH; Lu, LC; Xu, XY; Yang, T | 1 |
| Meng, XH; Tang, QJ; Xu, CS; Zhang, F; Zhang, JN | 1 |
| Chen, C; Geng, C; Hidru, TH; Li, H; Liu, Y; Tao, M; Zhang, Y; Zhi, L; Zou, L | 1 |
| Andrew, H; Armstrong, G; Hughes, TA; Jayne, DG; Kapur, N; Khot, MI; Maisey, T; Perry, SL | 1 |
| Chen, Y; Han, C; Kong, L; Luo, J; Ma, T; Xu, X; Zhang, C; Zhao, H | 1 |
| Belej, D; Blascakova, L; Horvath, D; Huntosova, V; Jancura, D; Miskovsky, P; Wagnieres, G | 1 |
| Fedoročko, P; Sačková, V; Šemeláková, M | 1 |
| Pei, Y; Pei, Z; Shang, K; Shao, C; Xu, H; Zhang, Y | 1 |
| Hsiao, YM; Ko, JL; Shih, CM; Wu, CH; Wu, WJ | 1 |
| Ahn, JC; Hwang, CW; Jin, JO; Kang, HW; Kim, H; Kim, SW; Seok, KH | 1 |
| Chen, XZ; Cui, J; Ding, YH; Fang, Q; Hu, SF; Ji, YS; Li, JY; Meng, LW; Qiao, JC; Song, D; Su, PP; Sun, XM; Wang, Q; Wu, Q; Xue, HB; Yang, XD | 1 |
| Abbasi Gamasaee, N; Aryan, H; Ghiasvand, S; Jangholi, E; Javidi, MA; Radmansouri, M; Shahriari, F; Zare Marzouni, H | 1 |
| Čellárová, E; Idkowiak, J; Kimáková, A; Kimáková, K; Marczak, Ł; Rodziewicz, P; Stobiecki, M | 1 |
| Ashby, NJS; Bar-Shaked, M; Ben-Eliezer, D; Yechiam, E | 1 |
| Caetano, W; César, GB; Consolaro, MEL; Damke, E; Damke, GMZF; Gonçalves, RS; Hioka, N; Kimura, E; Montanha, MC; Souza, RP | 1 |
| Corbi, ST; de Oliveira, GJPL; Macedo, PD; Marcantonio, RAC; Perussi, JR; Ribeiro, AO | 1 |
| Bruni, R; Cruciani, G; Dall'Asta, C; Dellafiora, L; Galaverna, G | 1 |
| Caetano, W; Cesar, GB; da Silva Junior, RC; de Morais, FAP; Enumo, A; Gonçalves, RS; Hioka, N; Miranda, N; Nakamura, CV; Vilsinski, BH | 1 |
| Fedoročko, P; Jendželovská, Z; Jendželovský, R; Kuchárová, B | 1 |
| Bilcik, B; Blascakova, L; Cavarga, I; Huntosova, V; Jurasekova, Z; Lenkavska, L; Macajova, M; Miskovsky, P | 1 |
| Ashrafi, B; Bahmani, M; Heydari, R; Khaksarian, M; Soroush, S; Taherikalani, M | 1 |
| Boonen, G; Bussmann, H; Drewe, J; Franken, S; Häberlein, H; Keksel, N; Unger, M | 1 |
| Bakowsky, U; Brüßler, J; Duse, L; Goergen, N; Jedelska, J; Pinnapireddy, SR; Plenagl, N; Seitz, BS | 1 |
| Cheng, W; Shao, L; Wang, Y; Wang, Z; Xu, L; Yi, K; Zhang, X; Zhang, Y; Zhao, T | 1 |
| Afford, SC; Attard, J; Bhogal, RH; Boteon, APCS; Boteon, YL; Hubscher, S; Mergental, H; Mirza, DF; Reynolds, G; Wallace, L | 1 |
| Abbruzzetti, S; Bianchini, P; Cavanna, L; Cozzolino, M; Delcanale, P; Diaspro, A; Giorgio, C; Nonell, S; Oneto, M; Pennacchietti, F; Pesce, L; Tognolini, M; Viappiani, C | 1 |
| Chorvat, D; Datta, S; Jancura, D; Jutkova, A; Miskovsky, P | 1 |
| Jin, L; Kang, T; Li, M; Liu, Z; Sun, P; Xing, H; Yao, Y; Zhang, Z | 1 |
| Altschmied, L; Bäumlein, H; Borisjuk, L; Franke, K; Gündel, A; Koch, M; Rizzo, P; Rutten, T; Scharfenberg, S; Sharbel, TF; Stark, P; Wessjohann, L | 1 |
| Cao, YF; Chen, TR; Dou, TY; Fang, HB; Ge, GB; Guo, WZ; Hou, J; Jin, Q; Wei, LH; Yu, Y; Zhang, SJ | 1 |
| Csupor, D; Kiss, N; Kocsubé, S; Németh, A; Papp, T; Rakk, D; Škrbić, B; Szekeres, A; Vágvölgyi, C; Vigneshwari, A | 1 |
| Chen, H; Gao, C; Jian, J; Jiang, BP; Lin, Z; Shen, XC; Yu, YX | 1 |
| Astrath, NGC; Caetano, W; Camargo, VG; Gonçalves, RS; Herculano, LS; Hioka, N; Lukasievicz, GVB; Malacarne, LC; Pereira, PCS; Zanuto, VS | 1 |
| Hatamipour, MS; Khanahmadi, M; Najafipour, I; Sadeh, P; Tahmasebi-Boldaji, R | 1 |
| Kılıç Süloğlu, A; Selmanoğlu, G; Sünnetçioğlu, MM; Yonar, D | 1 |
| Babinčák, M; Buríková, M; Fedoročko, P; Jendželovská, Z; Jendželovský, R; Košuth, J; Majerník, M; Ševc, J; Tonelli Gombalová, Z | 1 |
| Cvetanovic Zobenica, K; Etinski, M; Lacnjevac, U; Stanisavljev, D; Vasiljevic-Radovic, D | 1 |
| Behroozi, P; Ebrahimi, M; Khanahmadi, M; Moradi, K; Noormohammadi, N; Sobhani Najafabadi, A | 1 |
| Bao, Y; Hao, F; Huang, Y; Li, Y; Liang, C; Liu, L; Qiu, Y; Song, Z; Sun, L; Sun, Y; Wang, G; Wang, S; Wu, Y; Yang, S; Yang, X; Yao, X; Yi, J; Yu, C; Zheng, L | 1 |
| Majerz, I; Szymanski, S | 1 |
| Bakowsky, U; Brüßler, J; Dayyoub, E; Duse, L; Jedelska, J; Pinnapireddy, SR; Plenagl, N; Seitz, BS; Vögeling, H | 1 |
| Abbas, G; Chen, H; Diao, L; Feng, R; Huang, X; Li, G; Muhammad, I; Ren, Y; Wang, X; Zhang, R; Zhang, Y | 1 |
| Huntosova, V; Kozar, T; Stroffekova, K; Tomkova, S | 1 |
| Abrahamse, H; Kruger, CA; Naidoo, C | 1 |
| Bakowsky, U; Brüßler, J; Duse, L; Jedelska, J; Pinnapireddy, SR; Plenagl, N; Seitz, BS | 1 |
| Chen, Z; Du, X; Fu, H; He, C; Li, C; Liu, G; Shu, G; Xiao, R; Yin, L; Yuan, Z; Zhang, W; Zhou, J | 1 |
| Abrahamse, H; P George, B; R Mokoena, D | 1 |
| Carrubba, A; Lazzara, S; Napoli, E | 1 |
| Borghi-Pangoni, FB; Bruschi, ML; Junqueira, MV | 1 |
| Bai, M; Bao, Y; Huang, Y; Li, Y; Liang, C; Liu, L; Song, Z; Sun, L; Wang, S; Yang, H; Yi, J; Yu, C | 1 |
| Adam, PM; Brecht, M; Hauler, O; Liu, Q; Meixner, AJ; Ritz, R; Scholz, M; Wackenhut, F; Zur Oven-Krockhaus, S | 1 |
| Bona, E; Caetano, W; Campanerut-Sá, PAZ; Cesar, GB; Dias, VHC; Dos Santos, AR; Malacrida, AM; Mikcha, JMG; Silva, AF | 1 |
| Chen, J; Dai, Y; Ke, Z; Shen, L; Xie, A; Zou, D; Zou, Z | 1 |
| Farsad, K; Han, X; Jahangiri, Y; Moses, A; St Lorenz, A; Taratula, O; Xu, K; Yu, G | 1 |
| Demečková, V; Fedoročko, P; Hradická, P; Jendželovský, R; Macejová, M; Sačková, V | 1 |
| Li, B; Li, F; Lu, C; Teng, X | 1 |
| Kessel, D | 2 |
| Orzari Ribeiro, A; Rodrigues Perussi, J; Souza Amaral, L | 1 |
| Horvath, D; Huntosova, V; Lenkavska, L; Tomkova, S | 1 |
| Chorilli, M; de Araújo, PR; Fonseca-Santos, B; Kogawa, AC; Salgado, HRN | 1 |
| Caetano, W; César, GB; Consolaro, MEL; da Silva, VRS; Damke, E; Damke, GMZF; de Freitas Meirelles, LE; de Oliveira Silva, S; de Souza Bonfim-Mendonça, P; Gonçalves, RS; Hioka, N; Ratti, BA; Souza, RP | 1 |
| Falconi, M; Iacovelli, F; Romeo, A | 1 |
| Bigdeli, M; Jolodar, SK; Moghaddam, AH | 1 |
| Barth, S; Biteghe, FAN; Chalomie, NET; Davids, LM; Ndong, JC; Padayachee, E | 1 |
| Bálintová, M; Čellárová, E; Henzelyová, J; Kusari, S; Revuru, B | 1 |
| Caetano, W; de Oliveira, ACV; Gonçalves, RS; Hioka, N | 1 |
| Cruz, RCR; de Sousa, FD; de Souza, LM; Francielli de Oliveira, P; Tavares, DC | 1 |
| Altschmied, L; D'Auria, JC; Ravindran, BM; Rizzo, P; Rutten, T | 1 |
| Beneš, J; Staničová, J; Verebová, V | 1 |
| Alavian, F; Ghiasvand, S; Javidi, MA; Mohammadian, A; Mousavi, SA; Shahriari, F | 1 |
| Arita, GS; Baesso, ML; Bianchi, TP; Bonfim-Mendonça, PS; Caetano, W; Cesar, GB; Conrado, PCV; Cotica, ÉSK; da Silva Palácios, R; de Souza, M; Faria, DR; Galinari, CB; Gonçalves, RS; Malacarne, LC; Melo, RC; Mosca, VAB; Pereira, PCS; Sakita, KM; Svidzinski, TIE | 1 |
| Dev, A; Guchhait, P; Karmakar, S; Kushwaha, AC; Roy Choudhury, S; Sardoiwala, MN; Shrimali, N | 1 |
| Hung, A; Karagiannis, TC; Liang, J; Pitsillou, E; Ververis, K | 1 |
| Fan, D; Hu, J; Wang, T; Wei, S; Zhou, J; Zhou, L | 1 |
| Araújo, VHS; Bauab, TM; Calixto, GMF; Chorilli, M; de Araújo, PR; Oshiro-Junior, JA; Rodero, CF; Sato, MR | 1 |
| Gao, L; He, X; Huang, G; Jiang, X; Li, Y; Ni, Y; Wan, L; Wang, S; Wang, X; Zhao, H; Zhou, X; Zhou, Z | 1 |
| Cruz, LJ; Dong, X; Fu, J; Gu, Z; Hao, Y; He, Y; Ni, J; Qu, C; Yin, X; You, L; Yu, Z; Zeng, Y; Zhang, Z | 1 |
| Chen, L; Hu, J; Song, J; Tang, Z; Wei, S; Zhou, R | 1 |
| Chen, S; Li, J; Li, M; Su, H; Sun, P; Wei, J; Xing, H; Yang, D; Zhang, X | 1 |
| Cerchiaro, G; de Andrade, GP; de Souza, TFM; Girão, MJBC; Pinhal, MADS; Ribeiro, AO | 1 |
| Shang, H; Sun, L; Wu, Y; Xin, X | 1 |
| Arita, GS; Bonfim-Mendonça, PS; Caetano, W; Cesar, GB; Conrado, PCV; Gonçalves, RS; Hioka, N; Kioshima, ES; Sakita, KM; Svidzinski, TIE; Vicente, VA; Voidaleski, MF | 1 |
| Avdikos, I; Brestic, M; Emmanouilidou, C; Hilioti, Z; Koidou, V; Kosyan, A; Kotta, K; Kroustalaki, M; Papadopoulou, E; Pashalidis, A; Sytar, O; Valasiadis, D | 1 |
| Javidi, MA; Mehrparvar, B; Mohammadian, A; Piryaei, M; Shahriari, F | 1 |
| Bilčík, B; Čavarga, I; Datta, S; Huntošová, V; Jancura, D; Jutková, A; Kronek, J; Kundeková, B; Lenkavská, L; Máčajová, M; Miškovský, P | 1 |
| Ahn, YC; Jung, MJ; Kang, HW; Kim, JH; Kim, SW; Kwon, DY; Lee, H; Oak, C | 1 |
| Carrilho, E; Ma, HL; Perussi, JR; Varanda, LC | 1 |
| Chen, H; Cong, Y; Huang, X; Li, G; Oerlemans, R; Ren, Y; Shao, C; Zhang, R; Zhang, Y; Zou, M | 1 |
| Abdelsalam, AM; Ambreen, G; Amin, MU; Ayoub, AM; Bakowsky, U; Engelhardt, K; Fawaz, I; Garidel, P; Somaida, A; Tariq, I; Wojcik, M | 1 |
| Abu Dayyih, A; Abu Dayyih, W; Alawak, M; Amin, MU; Ayoub, AM; Bakowsky, U; Brüßler, J; Duse, L; Engelhardt, K; Preis, E | 1 |
| Li, Y; Li, Z; Liang, C; Liu, L; Sun, Y; Yang, G; Zheng, L | 1 |
| Saçıcı, E; Yesilada, E | 1 |
| Adamus, A; Engel, N; Hempfling, L; Seitz, G; Wagner, BR | 1 |
| Guan, QY; Han, YB; Tan, RX; Wang, XC; Wu, XM; Zhuang, WY | 1 |
| Adam, PM; Brecht, M; Gierschner, J; Liu, Q; Meixner, AJ; Wackenhut, F; Wang, L | 1 |
| Angulo-Pachón, CA; Bedrina, B; Falomir, E; Galindo, F; Marín, MJ; Miravet, JF; Torres-Martínez, A | 1 |
| Chen, M; Duan, Y; Liang, R; Wong, KH; Yang, Y | 1 |
| Chen, Y; Han, X; Li, X; Lu, Y; Zhai, X; Zhang, Y; Zhu, Y | 1 |
| Chen, J; Dou, T; Ge, G; Liu, K; Meng, Q; Sun, H; Wang, C; Wang, D; Wu, J; Zhao, S; Zhao, T | 1 |
| Almeida, AM; Aoki, PHB; Caetano, W; Camacho, SA; DeWolf, C; Gonçalves, RS; Pereira, LSA | 1 |
| Abbruzzetti, S; Bianchini, P; Cavanna, L; Delcanale, P; Diaspro, A; Lelli, D; Mariangeli, M; Moreno, A; Mussini, A; Uriati, E; Viappiani, C | 1 |
| Deng, QP; Shen, J; Wang, Y; Yu, HH; Zheng, QH; Zhou, JH | 1 |
| Abbasi, N; Ashrafi, B; Bahmani, M; Khaksarian, M; Rafieian-Kopaei, M; Taherikalani, M | 1 |
| Bassler, MC; Brecht, M; Meixner, AJ; Rammler, T; Ritz, R; Secic, I; Wackenhut, F; Zur Oven-Krockhaus, S | 1 |
| Salarian, M | 1 |
| Caetano, W; César, GB; Consolaro, MEL; Damke, E; Damke, GM; De Souza, MVF; Gonçalves, RS; Mari, NL; Meirelles, LEF; Shinobu-Mesquita, CS; Silva, VR | 1 |
| Abd-El-Azim, H; Ali, A; Aly, RG; Bell, SJ; Donnelly, RF; Furlong, F; Khalafallah, N; McCarthy, HO; Mcdaid, W; Nafee, N; Rahman, T; Ramadan, A; Tekko, IA; Vora, LK | 1 |
| Abdelsalam, AM; Amin, MU; Bakowsky, U; Bonsu, M; Dayyih, AA; Engelhardt, KH; Gutberlet, B; Preis, E | 1 |
| Cao, K; Chen, T; Guo, R; Jiao, Q; Pan, Q; Peng, Y; Ren, K; Sun, F; Yao, Q; Zhang, J; Zhang, Q; Zhang, Y | 1 |
| Akilov, O; Appel, J; Bhatia, N; Boh, E; Bohjanen, K; Carter, J; Dawes, K; DeSimone, JA; Donini, O; Duvic, M; Elston, D; Geskin, L; Girardi, M; Guitart, J; Haulenbeek, A; Huen, A; Kim, EJ; Kim, YH; Korman, NJ; Kuzel, TM; Lain, E; Lee, ST; Mangold, AR; Musiek, A; Nikbakht, N; Olsen, E; Pacheco, T; Pariser, D; Piette, W; Poligone, B; Pullion, C; Querfeld, C; Rook, AH; Rumage, A; Schaber, CJ; Seminario-Vidal, L; Shinohara, M; Straube, R; Wong, HK; Wood, GS; Zeitouni, N; Zwerner, JP | 1 |
| Pietrzak, M; Szabelski, M; Wieczorek, Z; Wołąkiewicz, G | 1 |
| Bilčík, B; Čavarga, I; Datta, S; Huntošová, V; Kronek, J; Kundeková, B; Máčajová, M; Meta, M; Miškovský, P | 1 |
| Bishayee, A; Choudhary, N; Collignon, TE; Tewari, D | 1 |
| Gusmão, LA; Machado, AEH; Perussi, JR | 1 |
| De Simone, BC; Mazzone, G; Russo, N; Toscano, M | 1 |
| Bernal, C; Carrilho, E; Ma, HL; Rodrigues Perussi, J; Urbaczek, AC; Zeferino Ribeiro de Souza, F | 1 |
| Bilčík, B; Čavarga, I; Grzegorzewska, AK; Kundeková, B; Máčajová, M; Meta, M | 1 |
| Almáši, M; Bánó, G; Bilčík, B; Hovan, A; Huntošová, V; Máčajová, M; Pevná, V; Zauška, Ľ; Zeleňák, V | 1 |
| Bakoshi, ABK; Balbinot, RB; Caetano, W; da Silva Junior, RC; da Silva Souza Campanholi, K; de Morais, FAP; de Oliveira Silva, S; Gonçalves, RS; Lazarin-Bidoia, D; Nakamura, CV; Ueda-Nakamura, T | 1 |
| Almáši, M; Benziane, A; Girman, V; Huntošová, V; Miklóšová, M; Pevná, V; Vámosi, G; Zauška, Ľ; Zeleňák, V | 1 |
55 review(s) available for hypericin and perylene
| Article | Year |
|---|---|
Hypericin and its photodynamic action.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Light; Perylene; Photochemistry; Photoreceptor Cells; Photosensitivity Disorders; Plants; Skin | 1986 |
Novel therapeutic and diagnostic applications of hypocrellins and hypericins.
Topics: Animals; Anthracenes; Antidepressive Agents; Antiviral Agents; Drugs, Chinese Herbal; Humans; Perylene; Phenol; Quinones; Radiation-Sensitizing Agents | 1995 |
The chemical and biological properties of hypericin--a compound with a broad spectrum of biological activities.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antiviral Agents; Biochemical Phenomena; Biochemistry; Humans; Perylene; Photochemistry; Protein Kinase C; Radiation-Sensitizing Agents | 1995 |
Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin.
Topics: Animals; Anthracenes; Apoptosis; Humans; Perylene; Photochemotherapy; Signal Transduction | 2000 |
Incidence and clinical relevance of the interactions and side effects of Hypericum preparations.
Topics: Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Contraindications; Dermatitis, Phototoxic; Drug Interactions; Epidemiologic Studies; Herb-Drug Interactions; Humans; Hypericum; Incidence; Perylene; Photosensitizing Agents; Plant Extracts; Plants, Medicinal; Radiation-Sensitizing Agents | 2001 |
A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
Topics: Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Humans; Hypericum; Perylene; Phytotherapy; Treatment Outcome | 2001 |
Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil.
Topics: Administration, Oral; Animals; Anthracenes; Chemistry, Pharmaceutical; Cosmetics; Depressive Disorder; Dizziness; Fatigue; Guinea Pigs; Humans; Hypericum; Immune System; Mice; Mutagenicity Tests; Perylene; Photosensitivity Disorders; Plant Preparations; Rats; Safety; Skin Diseases; Toxicity Tests | 2001 |
Hypericin in cancer treatment: more light on the way.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Cytochrome c Group; HeLa Cells; Humans; Hypericum; Microscopy, Fluorescence; Models, Biological; Molecular Structure; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2002 |
Hypericin--a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antiviral Agents; Humans; Macromolecular Substances; Perylene; Photosensitizing Agents | 2002 |
Fluorescence detection of bladder cancer: a review.
Topics: Administration, Intravesical; Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystoscopy; Dihematoporphyrin Ether; Fluorescence; Humans; Perylene; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2002 |
[Formulation of St. John's wort extract. A medicinal obstacle course].
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Drug Compounding; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Solvents; Terpenes | 2003 |
The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum).
Topics: Anthracenes; Anti-Bacterial Agents; Antineoplastic Agents; Bridged Bicyclo Compounds; Culture Techniques; Hypericum; Perylene; Phloroglucinol; Plants, Medicinal; Terpenes | 2004 |
Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers.
Topics: Animals; Anthracenes; Apoptosis; Cell Division; Humans; Mitochondria; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2003 |
[Fluorescence technique on diagnosis of urinary bladder carcinoma].
Topics: Aminolevulinic Acid; Anthracenes; Fluorescence; Humans; Perylene; Urinary Bladder Neoplasms | 2003 |
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neurotransmitter Agents; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Receptors, Dopamine D1; Receptors, Opioid; Terpenes | 2004 |
Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder.
Topics: Animals; Anthracenes; Carcinoma, Transitional Cell; Humans; Perylene; Photosensitizing Agents; Phototherapy; Tissue Distribution; Urinary Bladder Neoplasms | 2004 |
Hypericin--the facts about a controversial agent.
Topics: Animals; Anthracenes; Austria; Cell Death; Humans; Molecular Structure; Neoplasms; Perylene; Photochemotherapy; Phytotherapy; Reproducibility of Results; Viruses | 2005 |
The role of photodynamic diagnosis in the contemporary management of superficial bladder cancer.
Topics: Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Cystoscopy; Disease Progression; Hematuria; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 2005 |
Delivery of hypericin for photodynamic applications.
Topics: Animals; Anthracenes; Fluorescent Dyes; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Sensitivity and Specificity | 2006 |
St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Preparations; Terpenes; Treatment Outcome | 2005 |
Perylenequinones in photodynamic therapy: cellular versus vascular response.
Topics: Animals; Anthracenes; Apoptosis; Blood Vessels; Humans; Neoplasms; Perylene; Phenol; Photochemotherapy; Photosensitizing Agents; Quinones | 2006 |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2006 |
Cellular mechanisms and prospective applications of hypericin in photodynamic therapy.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Mitochondria; Neoplasms; Neovascularization, Pathologic; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Signal Transduction | 2006 |
Enhanced radiation sensitivity and radiation recall dermatitis (RRD) after hypericin therapy -- case report and review of literature.
Topics: Aged; Anthracenes; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Male; Perylene; Phytotherapy; Radiation Tolerance; Radiation-Sensitizing Agents; Radiodermatitis; Radiotherapy | 2006 |
[Hypericin and hyperforin: bioactive components of St. John's Wort (Hypericum perforatum). Their isolation, analysis and study of physiological effect].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
St. John's wort: role of active compounds for its mechanism of action and efficacy.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; Humans; Hypericum; Ice; Meta-Analysis as Topic; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2007 |
Recent developments in fluorescence cystoscopy: do novel agents bring a benefit?
Topics: Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystoscopy; Fluorescence; Fluorescent Dyes; Humans; Perylene; Practice Guidelines as Topic; Predictive Value of Tests; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2007 |
Potentiation of the photodynamic action of hypericin.
Topics: Adjuvants, Pharmaceutic; Animals; Anthracenes; Combined Modality Therapy; Humans; Neoplasms; Perylene; Photochemotherapy; Radiation-Sensitizing Agents | 2008 |
Hypericin lights up the way for the potential treatment of nasopharyngeal cancer by photodynamic therapy.
Topics: Animals; Anthracenes; Cytokines; Humans; Lipid Peroxidation; Matrix Metalloproteinase 1; Nasopharyngeal Neoplasms; Perylene; Photochemotherapy; Reactive Oxygen Species | 2006 |
Drug interactions with natural products at the blood brain barrier.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Biological Transport; Blood-Brain Barrier; Digoxin; Flavonoids; Herb-Drug Interactions; Humans; Perylene | 2008 |
Molecular mechanisms underlying St. John's wort drug interactions.
Topics: Animals; Anthracenes; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Enzyme Induction; Herb-Drug Interactions; Humans; Hypericum; Perylene; Photochemotherapy | 2008 |
Molecular imaging of cell death.
Topics: Animals; Annexin A5; Anthracenes; Antibodies, Monoclonal; Apoptosis; Bacteriocins; Cell Death; Glucaric Acid; Humans; Indoles; Models, Animal; Molecular Diagnostic Techniques; Molecular Probe Techniques; Myocardial Infarction; Necrosis; Organometallic Compounds; Organotechnetium Compounds; Peptides; Perylene; Radiopharmaceuticals; Stroke; Sulfonamides; Synaptotagmin I | 2009 |
Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
Topics: Anthracenes; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Bridged Bicyclo Compounds; Humans; Hypericum; Kava; Mood Disorders; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2009 |
Hypericins as potential leads for new therapeutics.
Topics: Anthracenes; Anti-Infective Agents; Antidepressive Agents; Cell Survival; Humans; Hypericum; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents | 2010 |
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Hypericum; Molecular Structure; Perylene; Phloroglucinol; Plant Preparations; Plants, Medicinal; Terpenes | 2010 |
New frontier in hypericin-mediated diagnosis of cancer with current optical technologies.
Topics: Anthracenes; Diagnostic Imaging; Fluorescence; Humans; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents | 2012 |
Molecular response to hypericin-induced photodamage.
Topics: Animals; Anthracenes; Antineoplastic Agents; Humans; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Signal Transduction | 2012 |
[Cellular and molecular effects of the antidepressant hyperforin on brain cells: Review of the literature].
Topics: Anthracenes; Antidepressive Agents; Brain; Hypericum; Neurons; Perylene; Phloroglucinol; Terpenes | 2014 |
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes | 2014 |
Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging.
Topics: Anthracenes; Humans; Necrosis; Optical Imaging; Perylene; Staining and Labeling | 2013 |
ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses.
Topics: Animals; Anthracenes; Autophagy; Cell Death; Endoplasmic Reticulum Stress; Humans; Immune System Phenomena; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents | 2014 |
Hypericin: chemical synthesis and biosynthesis.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antiviral Agents; Humans; Hypericum; Perylene; Plant Extracts | 2014 |
Photodynamic therapy for psoriasis.
Topics: Aminolevulinic Acid; Anthracenes; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Porphyrins; Psoriasis; Verteporfin | 2015 |
Hypericins: biotechnological production from cell and organ cultures.
Topics: Anthracenes; Biological Products; Biotechnology; Cell Culture Techniques; Hypericum; Perylene; Technology, Pharmaceutical | 2014 |
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.
Topics: Anthracenes; Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Selective Serotonin Reuptake Inhibitors; Terpenes | 2017 |
Yield enhancement strategies of rare pharmaceutical metabolites from endophytes.
Topics: Anthracenes; DNA Shuffling; Endophytes; Fermentation; Industrial Microbiology; Limonins; Metabolome; Paclitaxel; Perylene; Plants; Podophyllotoxin | 2018 |
Sonodynamic therapy: A potential treatment for atherosclerosis.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Atherosclerosis; Berberine; Cell Death; Chalcone; Curcumin; Emodin; Humans; Inflammation; Macrophages; Matrix Metalloproteinases; Mice; Neoplasms; Perylene; Photochemotherapy; Plaque, Atherosclerotic; Quinones; Reactive Oxygen Species; THP-1 Cells; Ultrasonic Therapy | 2018 |
Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma.
Topics: Aminolevulinic Acid; Anthracenes; Biopsy, Fine-Needle; Drug Carriers; Early Diagnosis; Humans; Indoles; Isoindoles; Light; Lymphatic Metastasis; Melanoma; Molecular Imaging; Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms | 2019 |
Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cannabidiol; Combined Modality Therapy; Female; Gold; Humans; Metal Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Treatment Outcome | 2019 |
A Review of Analytical Methods for the Determination of Hypericin in Foods, Herbal, Biological and Pharmaceutical Matrices.
Topics: Anthracenes; Humans; Hypericum; Perylene; Pharmaceutical Preparations; Photosensitizing Agents | 2020 |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in
Topics: Anthracenes; Antidepressive Agents; Antineoplastic Agents; Europe; Humans; Hypericum; Perylene; Phloroglucinol; Phytochemicals; Plant Extracts; Plant Proteins; Terpenes | 2020 |
Biophysical Characterization and Anticancer Activities of Photosensitive Phytoanthraquinones Represented by Hypericin and Its Model Compounds.
Topics: Animals; Anthracenes; Anthraquinones; Antineoplastic Agents; Humans; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents | 2020 |
Hypericin-mediated photodynamic therapy for the treatment of cancer: a review.
Topics: Anthracenes; Antineoplastic Agents; Humans; Molecular Targeted Therapy; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Signal Transduction | 2021 |
Hypericin in photobiological assays: An overview.
Topics: Anthracenes; Apoptosis; Cell Survival; Perylene; Photochemotherapy; Photosensitizing Agents | 2021 |
Hypericin and its anticancer effects: From mechanism of action to potential therapeutic application.
Topics: Anthracenes; Antineoplastic Agents; Colonic Neoplasms; Humans; Perylene | 2022 |
27 trial(s) available for hypericin and perylene
| Article | Year |
|---|---|
Treating AIDS with worts.
Topics: Acquired Immunodeficiency Syndrome; Anthracenes; Antiviral Agents; Humans; Perylene; Plants, Medicinal | 1991 |
Effects of hypericum extract on the sleep EEG in older volunteers.
Topics: Anthracenes; Antidepressive Agents; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Humans; Hypericum; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Sleep; Xanthenes | 1994 |
Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers.
Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Hypericum; Male; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Reference Values; Regression Analysis; Xanthenes | 1994 |
Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin.
Topics: Administration, Oral; Adult; Anthracenes; Antiviral Agents; Area Under Curve; Body Weight; Chromatography, High Pressure Liquid; Double-Blind Method; Half-Life; Humans; Injections, Intravenous; Male; Perylene | 1996 |
Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans.
Topics: Adult; Anthracenes; Antidepressive Agents; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Erythema; Female; Humans; Male; Perylene; Photosensitivity Disorders | 1997 |
Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG.
Topics: Adult; Anthracenes; Bridged Bicyclo Compounds; Cerebral Cortex; Electroencephalography; Female; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes | 1998 |
Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.
Topics: Administration, Oral; Adult; Anthracenes; Anti-HIV Agents; CD4 Lymphocyte Count; Dermatitis, Phototoxic; Female; Follow-Up Studies; HIV Core Protein p24; HIV Infections; Humans; Injections, Intravenous; Male; Perylene; RNA, Viral; Statistics, Nonparametric; Viral Load | 1999 |
Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.
Topics: Adult; Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Cross-Over Studies; Double-Blind Method; Ericales; Humans; Hydrocortisone; Male; Middle Aged; Perylene; Phloroglucinol; Plants, Medicinal; Prolactin; Somatostatin; Terpenes | 1999 |
Effect of topical application of Hypericum perforatum extract (St. John's wort) on skin sensitivity to solar simulated radiation.
Topics: Administration, Cutaneous; Adolescent; Adult; Anthracenes; Erythema; Female; Forearm; Humans; Hypericum; Male; Middle Aged; Ointments; Perylene; Photosensitizing Agents; Plant Extracts; Plant Oils; Plants, Medicinal; Prospective Studies; Radiation-Sensitizing Agents; Reference Values; Skin; Sunlight | 2000 |
Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection.
Topics: Adolescent; Adult; Anthracenes; Antiviral Agents; Aspartate Aminotransferases; Female; Follow-Up Studies; Half-Life; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Perylene; Photosensitivity Disorders; RNA, Viral | 2001 |
Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology.
Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gelatin; Humans; Hypericum; Male; Mass Spectrometry; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Reference Values; Terpenes | 2000 |
Single-dose and steady-state administration of Hypericum perforatum extract (St John's Wort) does not influence skin sensitivity to UV radiation, visible light, and solar-simulated radiation.
Topics: Animals; Anthracenes; Data Interpretation, Statistical; Erythema; Humans; Hypericum; Perylene; Plants, Medicinal; Prospective Studies; Radiation-Sensitizing Agents; Skin; Sunlight; Time Factors; Ultraviolet Rays | 2001 |
Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.
Topics: Adult; Animals; Anthracenes; Antidepressive Agents; Brain Chemistry; Bridged Bicyclo Compounds; Corticosterone; Cross-Over Studies; Double-Blind Method; Humans; Hypericum; Ketanserin; Male; Middle Aged; Neurosecretory Systems; Perylene; Phloroglucinol; Piperazines; Plant Extracts; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Terpenes | 2001 |
Impact of cytochrome P-450 inhibition by cimetidine and induction by carbamazepine on the kinetics of hypericin and pseudohypericin in healthy volunteers.
Topics: Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Humans; Hypericum; Perylene; Time Factors | 2004 |
Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Adult; Anthracenes; Autonomic Nervous System; Cardiovascular Physiological Phenomena; Catecholamines; Cross-Over Studies; Double-Blind Method; Female; Hemodynamics; Humans; Hypericum; Imipramine; Male; Methoxyhydroxyphenylglycol; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Perylene; Posture; Supine Position | 2004 |
Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet.
Topics: Adolescent; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Anthracenes; Antineoplastic Agents; Chemotherapy, Adjuvant; Drug Screening Assays, Antitumor; Gene Expression; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Oxindoles; Perylene; Photochemotherapy; Propionates; Protein-Tyrosine Kinases; Proteins; Pyrroles; Survival Rate | 2005 |
Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.
Topics: Adolescent; Adult; Anthracenes; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
Investigation of the effect on photosensitivity following multiple oral dosing of two different hypericum extracts in healthy men.
Topics: Adolescent; Adult; Anthracenes; Erythema; Humans; Hypericum; Hypersensitivity; Light; Male; Middle Aged; Perylene; Plant Extracts; Skin | 2006 |
Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial.
Topics: Administration, Oral; Adult; Anthracenes; Area Under Curve; Benzazepines; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrocardiography; Female; Gastrointestinal Tract; Half-Life; Headache; Heart Rate; Herb-Drug Interactions; Humans; Hydrocortisone; Hypericum; Ivabradine; Male; Metabolic Clearance Rate; Perylene; Plant Preparations; Tablets | 2006 |
Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study.
Topics: Aged; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Burning Mouth Syndrome; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Statistics, Nonparametric; Terpenes; Treatment Outcome | 2008 |
A phase II placebo-controlled study of photodynamic therapy with topical hypericin and visible light irradiation in the treatment of cutaneous T-cell lymphoma and psoriasis.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anthracenes; Antineoplastic Agents; Female; Humans; Light; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Perylene; Photochemotherapy; Phototherapy; Placebos; Psoriasis; Skin Neoplasms; Treatment Outcome; Young Adult | 2010 |
Hypericum perforatum for the treatment of premenstrual syndrome.
Topics: Adult; Anthracenes; Double-Blind Method; Female; Humans; Hypericum; Perylene; Phytotherapy; Premenstrual Syndrome; Prospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anthracenes; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Perylene | 2011 |
A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Cystoscopy; Dose-Response Relationship, Drug; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Neoplasm Invasiveness; Perylene; Povidone; Prospective Studies; Sensitivity and Specificity; Solubility; Urinary Bladder Neoplasms | 2015 |
The acute effect of Hypericum perforatum on short-term memory in healthy adults.
Topics: Adult; Affect; Anthracenes; Anxiety; Attention; Double-Blind Method; Female; Healthy Volunteers; Humans; Hypericum; Male; Memory, Short-Term; Nootropic Agents; Perylene; Plant Preparations; Young Adult | 2019 |
Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial.
Topics: Adult; Anthracenes; Female; Humans; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Mycosis Fungoides; Ointments; Perylene; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms; Treatment Outcome | 2022 |
791 other study(ies) available for hypericin and perylene
| Article | Year |
|---|---|
Spectroscopic characterization of the Stentor photoreceptor.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Ciliophora; Circular Dichroism; Hydrogen-Ion Concentration; Hydrolysis; Light; Perylene; Phenanthrenes; Photoreceptor Cells; Pigments, Biological; Polycyclic Compounds; Spectrometry, Fluorescence | 1979 |
Inactivation of the human immunodeficiency virus by hypericin: evidence for photochemical alterations of p24 and a block in uncoating.
Topics: Anthracenes; CD4-Positive T-Lymphocytes; Cell Fusion; HIV; HIV Core Protein p24; HIV Envelope Protein gp120; Perylene; Recombinant Proteins; RNA-Directed DNA Polymerase; Time Factors; Virus Replication | 1992 |
Oxygen dependence of hypericin-induced phototoxicity to EMT6 mouse mammary carcinoma cells.
Topics: Aerobiosis; Animals; Anthracenes; Cell Hypoxia; Cell Survival; Light; Mammary Neoplasms, Experimental; Mice; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Tumor Stem Cell Assay | 1992 |
Resonance Raman and surface-enhanced resonance Raman spectroscopy of hypericin.
Topics: Anthracenes; Molecular Structure; Perylene; Photochemistry; Radiation-Sensitizing Agents; Spectrum Analysis, Raman | 1992 |
Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase.
Topics: Animals; Anthracenes; Cattle; Light; Mitochondria, Heart; Oxidoreductases; Oxygen; Perylene; Radiation-Sensitizing Agents; Singlet Oxygen | 1992 |
Antiviral activities of hypericin.
Topics: Animals; Anthracenes; Antigens, Viral; Cell Line; Cell Survival; Cytomegalovirus; Cytopathogenic Effect, Viral; Fluorescent Antibody Technique; HIV-1; Humans; Light; Mice; Perylene; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sindbis Virus; Time Factors; Tumor Cells, Cultured; Vero Cells; Viral Plaque Assay | 1991 |
Antiviral activity of the photoactive plant pigment hypericin.
Topics: Animals; Anthracenes; Antiviral Agents; Cell Line; Cytomegalovirus; HIV-1; Humans; Light; Mice; Perylene; Radiation-Sensitizing Agents | 1991 |
In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives.
Topics: Animals; Anthracenes; Anthraquinones; Antiviral Agents; Emodin; HeLa Cells; Humans; Perylene; Polysorbates; Respirovirus; Simplexvirus; Vaccinia virus; Vero Cells; Vesicular stomatitis Indiana virus; Viruses | 1991 |
Calphostin (UCN1028) and calphostin related compounds, a new class of specific and potent inhibitors of protein kinase C.
Topics: Animals; Anthracenes; Cell Division; Cell Line; Cladosporium; Humans; Mice; Molecular Structure; Naphthalenes; Perylene; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Protein Kinase C; Structure-Activity Relationship | 1990 |
Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses.
Topics: Animals; Anthracenes; Antiviral Agents; DNA Viruses; Encephalitis; Friend murine leukemia virus; Herpes Simplex; Leukemia, Experimental; Male; Mice; Mice, Inbred DBA; Perylene; RNA Viruses; RNA-Directed DNA Polymerase; Simplexvirus; Viral Envelope Proteins; Virus Activation | 1990 |
Antiretroviral activity of synthetic hypericin and related analogs.
Topics: Animals; Anthracenes; Antiviral Agents; Cells, Cultured; Herpesvirus 3, Equid; Horses; Molecular Structure; Perylene; RNA-Directed DNA Polymerase; Structure-Activity Relationship | 1990 |
Photosensitization is required for inactivation of equine infectious anemia virus by hypericin.
Topics: Anthracenes; Antiviral Agents; Darkness; Infectious Anemia Virus, Equine; Light; Perylene; Radiation-Sensitizing Agents; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 1991 |
New AIDS drugs.
Topics: Acquired Immunodeficiency Syndrome; Anthracenes; Antiviral Agents; Azepines; Humans; Nevirapine; Perylene; Pyridines; Reverse Transcriptase Inhibitors | 1991 |
Photosensitization of aqueous model systems by hypericin.
Topics: Animals; Anthracenes; Cattle; Erythrocyte Membrane; Humans; Kinetics; Light; Lipid Peroxidation; Muramidase; Perylene; Photochemistry; Scattering, Radiation; Serum Albumin; Solubility; Spectrometry, Fluorescence; Spectrophotometry; Water | 1992 |
A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography.
Topics: Animals; Anthracenes; Antiviral Agents; Body Fluids; Chromatography, High Pressure Liquid; Mice; Mice, Inbred BALB C; Molecular Structure; Perylene; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solubility; Solvents; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry | 1991 |
[Genotoxicity of a standardized Hypericum extract].
Topics: Animals; Anthracenes; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA; Female; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Liver; Lymphocyte Activation; Mesocricetus; Mice; Mutagenicity Tests; Mutagens; Perylene; Plant Extracts; Rats; Rats, Inbred Strains | 1990 |
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.
Topics: Animals; Anthracenes; Antiviral Agents; Benz(a)Anthracenes; Cell Line; Friend murine leukemia virus; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Perylene; Retroviridae; Retroviridae Infections | 1989 |
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity.
Topics: Animals; Anthracenes; Antiviral Agents; Benz(a)Anthracenes; Brain; Calpain; Cattle; Cells, Cultured; HIV; Mice; Mice, Inbred BALB C; Molecular Structure; Myocardium; Myosin-Light-Chain Kinase; Perylene; Phosphorylation; Protein Kinase C; Rats; Retroviridae | 1989 |
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.
Topics: Animals; Anthracenes; Antigens, Viral; Antiviral Agents; Benz(a)Anthracenes; Chemical Phenomena; Chemistry; Friend murine leukemia virus; Gene Expression Regulation; H-2 Antigens; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred Strains; Perylene; Retroviridae; Retroviridae Infections; RNA, Messenger; RNA, Viral | 1988 |
Inhibition of monoamine oxidase by hypericin.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Brain; In Vitro Techniques; Monoamine Oxidase Inhibitors; Perylene; Rats | 1984 |
[Antidepressive effect of a Hypericum extract standardized to an active hypericine complex. Biochemical and clinical studies].
Topics: Adult; Aged; Anthracenes; Antidepressive Agents; Benz(a)Anthracenes; Depressive Disorder; Electrocardiography; Electroencephalography; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Perylene; Plant Extracts | 1984 |
An investigation of the type of photosensitization caused by the ingestion of St John's Wort (Hypericum perforatum) by calves.
Topics: Animals; Anthracenes; Cattle; Cattle Diseases; Creatine Kinase; Liver Circulation; Perylene; Photosensitivity Disorders; Plant Poisoning; Plants, Toxic; Skin; Sulfobromophthalein | 1981 |
Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors.
Topics: Alkaloids; Alkylating Agents; Anthracenes; Benzophenanthridines; Binding Sites; Carcinogens; Cysteine; Enzyme Inhibitors; Hydrogen Peroxide; Isoenzymes; Isoquinolines; Naphthalenes; Nitric Oxide; Oxidants; Periodic Acid; Perylene; Phenanthridines; Phorbol Esters; Phosphotransferases; Protein Kinase C | 1995 |
Inhibition of neutrophil superoxide generation by hypericin, an antiretroviral agent.
Topics: Anthracenes; Antiviral Agents; Azides; Cells, Cultured; Deferoxamine; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Humans; Light; Lipid Peroxides; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen; Perylene; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Roles of oxygen and photoinduced acidification in the light-dependent antiviral activity of hypocrellin A.
Topics: Anthracenes; Antiviral Agents; HIV; Hydrogen-Ion Concentration; Light; Oxygen; Perylene; Phenol; Photochemistry; Quinones | 1995 |
Photodynamic inactivation of radiation leukemia virus produced from hypericin-treated cells.
Topics: Anthracenes; Cells, Cultured; Dose-Response Relationship, Drug; Light; Perylene; Radiation Leukemia Virus; Radiation-Sensitizing Agents; RNA-Directed DNA Polymerase; Viral Proteins; Virulence | 1993 |
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Gossypol; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Naphthalenes; Perylene; Phenanthridines; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Time Factors; Tumor Cells, Cultured | 1994 |
Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C.
Topics: Alkaloids; Anthracenes; Antineoplastic Agents; Apoptosis; Cell Division; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Inhibitors; Humans; In Vitro Techniques; Neuroblastoma; Perylene; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 1995 |
Spectroscopic and photoacoustic studies of hypericin embedded in liposomes as a photoreceptor model.
Topics: Acoustics; Animals; Anthracenes; Calorimetry; Eukaryota; Liposomes; Perylene; Photoreceptor Cells, Invertebrate; Pigments, Biological; Spectrum Analysis | 1995 |
Effect of the antiretroviral agent hypericin on rat liver mitochondria.
Topics: Animals; Anthracenes; Antiviral Agents; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; HIV-1; Intracellular Membranes; Lipid Peroxidation; Mitochondria, Liver; Oxidative Phosphorylation; Oxidoreductases; Oxygen; Perylene; Rats; Spin Labels | 1995 |
Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation.
Topics: Animals; Anthracenes; Antiviral Agents; Cell Line; Chick Embryo; Dose-Response Relationship, Drug; Giant Cells; Hemolysis; HIV Reverse Transcriptase; HIV-1; Humans; In Vitro Techniques; Influenza A virus; Kinetics; Light; Lymphocytes; Membrane Fusion; Parainfluenza Virus 1, Human; Perylene; Radiation-Sensitizing Agents; RNA-Directed DNA Polymerase; Rose Bengal; Vesicular stomatitis Indiana virus | 1993 |
Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5.
Topics: Anthracenes; Catalase; Cell Line; Cell Survival; Darkness; Deferoxamine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Fibroblasts; Histidine; Humans; Kinetics; Light; Perylene; Photochemotherapy; Piperazines; Radiation-Protective Agents; Radiation-Sensitizing Agents; Superoxide Dismutase; Time Factors | 1995 |
Inactivation and removal of blood-borne viruses.
Topics: Anthracenes; Antiviral Agents; Blood; Blood Transfusion; Furocoumarins; Humans; Immunoglobulin G; Indoles; Isoindoles; Light; Methylene Blue; Perylene; Virus Diseases; Viruses | 1995 |
Hypericin as an inactivator of infectious viruses in blood components.
Topics: Anthracenes; Antiviral Agents; Blood; Blood Proteins; Blood Transfusion; Cell Line; Cell Membrane; Erythrocytes; HIV-1; Humans; Hydrogen-Ion Concentration; Light; Perylene; Virus Physiological Phenomena; Viruses | 1995 |
Photosensitized inhibition of growth factor-regulated protein kinases by hypericin.
Topics: Amino Acid Sequence; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Cytosol; ErbB Receptors; Growth Substances; Kinetics; Light; Molecular Sequence Data; Perylene; Photosensitizing Agents; Protein Kinase Inhibitors; Receptor, Insulin | 1995 |
Hypericin: a potential antiglioma therapy.
Topics: Anthracenes; Apoptosis; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Glioma; Humans; Perylene; Phototherapy; Protein Kinase C; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1994 |
Light-dependent inhibition of protein kinase C and superoxide generation of neutrophils by hypericin, an antiretroviral agent.
Topics: Animals; Anthracenes; Antiviral Agents; Brain; Dose-Response Relationship, Radiation; Friend murine leukemia virus; Guinea Pigs; Light; Male; Mice; Mice, Inbred C3H; Neutrophils; Perylene; Photosensitizing Agents; Protein Kinase C; Rats; Rats, Sprague-Dawley; Respiratory Burst; Retroviridae Infections; Splenomegaly; Superoxides; Tumor Virus Infections | 1995 |
Inhibition of MAO and COMT by hypericum extracts and hypericin.
Topics: Animals; Anthracenes; Antidepressive Agents; Catechol O-Methyltransferase Inhibitors; Hypericum; In Vitro Techniques; Monoamine Oxidase Inhibitors; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Swine; Xanthenes | 1994 |
Pharmaceutical quality of hypericum extracts.
Topics: Anthracenes; Antidepressive Agents; Hypericum; Molecular Structure; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1994 |
Antiviral assays on phytochemicals: the influence of reaction parameters.
Topics: 3T3 Cells; Animals; Anthracenes; Antiviral Agents; Chlorocebus aethiops; Culture Media; Mice; Perylene; Photochemistry; Plant Extracts; Sindbis Virus; Vero Cells | 1994 |
Hypocrellin, from Hypocrella bambuase, is phototoxic to human immunodeficiency virus.
Topics: 3T3 Cells; Animals; Anthracenes; Antiviral Agents; Cell Line; Cytomegalovirus; Darkness; HIV-1; Humans; Hypocreales; Light; Mice; Perylene; Phenol; Quinones; Radiation-Sensitizing Agents | 1994 |
Hypericin uptake in rabbits and nude mice transplanted with human squamous cell carcinomas: study of a new sensitizer for laser phototherapy.
Topics: Animals; Anthracenes; Carcinoma, Squamous Cell; Humans; Lung; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Perylene; Photochemotherapy; Rabbits; Radiation-Sensitizing Agents; Spleen; Time Factors; Tissue Distribution | 1994 |
Chemiluminescent activation of the antiviral activity of hypericin: a molecular flashlight.
Topics: Animals; Anthracenes; Antiviral Agents; Cell Line; Firefly Luciferin; HIV; Horses; Infectious Anemia Virus, Equine; Luciferases; Luminescent Measurements; Perylene; Photochemotherapy; Skin; Spectrophotometry | 1994 |
Laser photosensitization of cells by hypericin.
Topics: Animals; Anthracenes; Cell Death; Cell Line; Lasers; Perylene; Photosensitizing Agents; Rats; Tumor Cells, Cultured | 1994 |
Hypericin photosensitization in aqueous model systems.
Topics: Animals; Anthracenes; Cattle; Erythrocyte Membrane; Erythrocytes; Hemolysis; In Vitro Techniques; Liposomes; Oxygen; Perylene; Photosensitizing Agents; Singlet Oxygen; Water | 1994 |
Studies of sheep experimentally poisoned with Hypericum perforatum.
Topics: Animals; Anthracenes; Disease Models, Animal; Enzymes; Hemodynamics; Perylene; Plant Poisoning; Plants, Toxic; Sheep; Sheep Diseases | 1993 |
Measurement of formal potentials for hypericin in dimethylsulfoxide.
Topics: Anthracenes; Dimethyl Sulfoxide; Oxidation-Reduction; Perylene; Potentiometry; Radiation-Sensitizing Agents | 1993 |
Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin.
Topics: Animals; Anthracenes; ErbB Receptors; Humans; Light; Membranes; Mice; Perylene; Phosphorylation; Radiation-Sensitizing Agents; Temperature; Time Factors; Tumor Cells, Cultured | 1993 |
Lowest excited triplet states of hypericin and isohypericin.
Topics: Anthracenes; Cold Temperature; Isomerism; Kinetics; Luminescent Measurements; Perylene; Radiation-Sensitizing Agents; Spectrometry, Fluorescence | 1993 |
Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice.
Topics: Animals; Anthracenes; Antiviral Agents; Friend murine leukemia virus; Leukemia, Experimental; Male; Mice; Mice, Inbred BALB C; Perylene; Photochemotherapy; Rose Bengal; Splenomegaly | 1993 |
Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination.
Topics: Anthracenes; Antineoplastic Agents; Benzoquinones; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Light; Oxygen; Perylene; Photosensitizing Agents; Piperidones; Reactive Oxygen Species; Singlet Oxygen; Spin Labels; Superoxides; Triacetoneamine-N-Oxyl | 1993 |
The importance of light in the anti-HIV effect of hypericin.
Topics: Anthracenes; Antiviral Agents; Cytopathogenic Effect, Viral; HIV Core Protein p24; HIV-1; Light; Perylene; Photochemistry; Plants, Medicinal | 1993 |
Inhibition of duck hepatitis B virus replication by hypericin.
Topics: Animals; Anthracenes; Antiviral Agents; Blotting, Western; Cell Line; Depression, Chemical; DNA Replication; DNA, Viral; Ducks; Electrophoresis, Polyacrylamide Gel; Hepatitis B Virus, Duck; Nucleic Acid Synthesis Inhibitors; Perylene; Viral Envelope Proteins; Virus Replication | 1993 |
Subcellular distribution of hypericin in human cancer cells.
Topics: Anthracenes; Antiviral Agents; Breast Neoplasms; Fluorometry; Humans; Perylene; Protein Kinase C; Spectrophotometry, Ultraviolet; Subcellular Fractions | 1995 |
A comparative analysis of the photosensitized inhibition of growth-factor regulated protein kinases by hypericin-derivatives.
Topics: Animals; Anthracenes; Enzyme Inhibitors; ErbB Receptors; Growth Substances; Molecular Structure; Perylene; Photochemotherapy; Photosensitizing Agents; Protein Kinase Inhibitors; Protein Kinases; Quinones; Receptor, Insulin; Recombinant Proteins; Structure-Activity Relationship | 1996 |
Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens.
Topics: Anthracenes; Anthraquinones; Antiviral Agents; Herpesvirus 1, Human; Lichens; Light; Molecular Structure; Perylene; Structure-Activity Relationship | 1996 |
Hypericin: a new laser phototargeting agent for human cancer cells.
Topics: Anthracenes; Cell Survival; Combined Modality Therapy; Drug Screening Assays, Antitumor; Fiber Optic Technology; Humans; Laser Coagulation; Optical Fibers; Perylene; Radiation-Sensitizing Agents; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1996 |
High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages.
Topics: Alcoholic Beverages; Anthracenes; Antiviral Agents; Chromatography, High Pressure Liquid; Perylene; Plant Extracts; Plants, Medicinal; Sensitivity and Specificity; Spectrometry, Fluorescence; Vegetables | 1996 |
Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C.
Topics: Animals; Anthracenes; Apoptosis; Carcinogens; Cattle; Cell Division; Cells, Cultured; DNA; DNA Replication; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Perylene; Phorbol 12,13-Dibutyrate; Pigment Epithelium of Eye; Protein Kinase C; Time Factors; Tumor Necrosis Factor-alpha | 1996 |
The effect of purified extract of Fagopyrum esculentum (buckwheat) on protein kinases involved in signal transduction pathways.
Topics: 3T3 Cells; Animals; Anthracenes; Carcinoma, Squamous Cell; Cell Line; Edible Grain; Enzyme Inhibitors; ErbB Receptors; Humans; Mice; Perylene; Plant Extracts; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Receptor, Insulin; Signal Transduction; Tumor Cells, Cultured | 1996 |
Production of hypericin, pseudohypericin and flavonoids in cell cultures of various Hypericum species and their chemotypes.
Topics: Animals; Anthracenes; Cells, Cultured; Flavonoids; Perylene; Plant Cells; Plants; Rats; Species Specificity | 1996 |
Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application.
Topics: Adenoma; Animals; Anthracenes; Apoptosis; Cell Division; Perylene; Pituitary Neoplasms; Protein Kinase C; Rats; Tumor Cells, Cultured | 1996 |
Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells.
Topics: Anthracenes; Humans; Lipid Peroxidation; Melanoma; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1996 |
Hypericin-induced phototoxicity in cultured fibroblasts and swine erythrocytes.
Topics: 3T3 Cells; Animals; Anthracenes; Dermatitis, Phototoxic; Erythrocytes; Fibroblasts; In Vitro Techniques; Mice; Perylene; Photobiology; Photosensitizing Agents; Swine | 1996 |
Sensitization of photohemolysis by hypericin and Photofrin.
Topics: Animals; Anthracenes; Cattle; Dihematoporphyrin Ether; Erythrocytes; Hemolysis; Mathematical Computing; Models, Biological; Perylene; Photolysis; Photosensitizing Agents | 1996 |
Hypericin site specific interactions within polynucleotides used as DNA model compounds.
Topics: Anthracenes; Antiviral Agents; Binding Sites; Guanine; Molecular Structure; Perylene; Poly C; Poly dA-dT; Poly G; Polydeoxyribonucleotides; Polynucleotides | 1995 |
Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report.
Topics: Adult; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Brain Neoplasms; Cell Division; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Dominance, Cerebral; Dose-Response Relationship, Drug; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Neoplasm, Residual; Perylene; Radiotherapy, Adjuvant; Reoperation; Tamoxifen; Tumor Cells, Cultured | 1996 |
Effects of anthralin and hypericin on growth factor signalling and cell proliferation in vitro.
Topics: Anthracenes; Anthralin; Cell Division; Cells, Cultured; DNA; ErbB Receptors; Growth Substances; Humans; Perylene; Phosphorylation; Signal Transduction | 1995 |
Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin.
Topics: Animals; Anthracenes; Biological Assay; Guinea Pigs; Lasers; Linoleic Acid; Linoleic Acids; Muscle Contraction; Oxidation-Reduction; Perylene; Photosensitizing Agents; Skin | 1996 |
Hypericin in phototherapy.
Topics: Aged; Anthracenes; Humans; Male; Mesothelioma; Neoplasm Recurrence, Local; Perylene; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms; Testicular Neoplasms | 1996 |
Differential cytotoxic effects induced after photosensitization by hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Survival; Humans; Mice; Microscopy, Confocal; Perylene; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1997 |
Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum.
Topics: Animals; Anthracenes; Antidepressive Agents; Biflavonoids; Binding, Competitive; Brain; Cells, Cultured; Flavonoids; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Perylene; Plant Extracts; Plants, Medicinal; Rats | 1997 |
Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Mass Spectrometry; Perylene; Plant Extracts; Plants, Medicinal | 1997 |
Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53.
Topics: Anthracenes; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Apoptosis; bcl-2-Associated X Protein; Cell Division; Drug Resistance; fas Receptor; Glioma; Humans; Light; Naphthalenes; Perylene; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA; Tamoxifen; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro.
Topics: Animals; Anthracenes; Basement Membrane; Blood; Cattle; Cell Count; Cell Division; Cells, Cultured; Choroid; DNA; DNA Replication; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Light; Neovascularization, Physiologic; Perylene; Protein Kinase C; Radiation-Sensitizing Agents | 1997 |
Binding, uptake, and transport of hypericin by Caco-2 cell monolayers.
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Biological Transport; Caco-2 Cells; Cyclodextrins; Drug Interactions; Humans; Liposomes; Microscopy, Confocal; Perylene; Solubility; Spectrophotometry, Ultraviolet | 1997 |
Laser chemotherapy of human carcinoma cells with three new anticancer drugs.
Topics: Anthracenes; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Isoquinolines; Laser Therapy; Neodymium; Perylene; Phosphates; Photochemotherapy; Pyrazoles; Pyrazolones; Radiation-Sensitizing Agents; Titanium; Tumor Cells, Cultured | 1997 |
Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization.
Topics: Anthracenes; Antineoplastic Agents; Cell Division; HeLa Cells; Humans; Microscopy, Confocal; Perylene; Photochemistry; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1998 |
Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor.
Topics: Anthracenes; Antineoplastic Agents; Brain Neoplasms; Cell Movement; Cells, Cultured; Enzyme Inhibitors; Glioma; Humans; Neoplasm Invasiveness; Perylene; Protein Kinase C | 1997 |
Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding.
Topics: Anthracenes; Antidepressive Agents; Humans; Kinetics; Neurotransmitter Uptake Inhibitors; Perylene; Plant Extracts; Radioligand Assay; Receptors, Cell Surface; Receptors, sigma; Selective Serotonin Reuptake Inhibitors | 1998 |
Antioxidant enzyme response to hypericin in EMT6 mouse mammary carcinoma cells.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antioxidants; Catalase; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Mammary Neoplasms, Experimental; Mice; Perylene; Superoxide Dismutase; Tumor Cells, Cultured | 1998 |
Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test.
Topics: Animals; Anthracenes; Antidepressive Agents; Male; Perylene; Rats; Solubility; Stress, Psychological; Swimming | 1998 |
[Therapy of mild to medium degree depression].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Depressive Disorder; Humans; Monoamine Oxidase Inhibitors; Perylene; Phloroglucinol; Plant Extracts; Plant Oils; Severity of Illness Index; Terpenes | 1998 |
Time-course of hypericin phototoxicity and effect on mitochondrial energies in EMT6 mouse mammary carcinoma cells.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Cell Membrane; Cell Respiration; Cell Survival; Dose-Response Relationship, Drug; Energy Metabolism; Female; Intracellular Fluid; L-Lactate Dehydrogenase; Light; Lipid Peroxidation; Mammary Neoplasms, Animal; Mice; Mitochondria; Oxidative Stress; Perylene; Photosensitizing Agents; Protein Kinase C; Proteins; Thiobarbituric Acid Reactive Substances; Time Factors; Tumor Cells, Cultured | 1998 |
Sequence specific interaction of the antiretrovirally active drug hypericin with 5'ATGGCAGGATAT3' oligonucleotide: a resonance Raman spectroscopy study.
Topics: Anthracenes; Antineoplastic Agents; Antiviral Agents; Oligodeoxyribonucleotides; Perylene; Spectrum Analysis, Raman | 1998 |
Photoactivated hypericin is an anti-proliferative agent that induces a high rate of apoptotic death of normal, transformed, and malignant T lymphocytes: implications for the treatment of cutaneous lymphoproliferative and inflammatory disorders.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Cells, Cultured; Humans; Keratitis; Lymphocyte Activation; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Perylene; Photochemotherapy; Skin Neoplasms; T-Lymphocytes; Ultraviolet Rays | 1998 |
Is St. John's wort (Hypericum perforatum) an effective antidepressant?
Topics: Animals; Anthracenes; Antidepressive Agents; Depressive Disorder; Humans; Hypericum; Nonprescription Drugs; Perylene; Phytotherapy; Plant Extracts; Plants, Medicinal; Protein Kinase C; Quercetin; Rats; Xanthenes | 1998 |
Kinetics and yield of singlet oxygen photosensitized by hypericin in organic and biological media.
Topics: Anthracenes; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Liposomes; Oxygen; Perylene; Photochemistry; Photosensitizing Agents; Singlet Oxygen; Solutions; Spectrophotometry | 1998 |
Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism.
Topics: Anthracenes; Anthraquinones; Binding, Competitive; HIV Integrase Inhibitors; HIV-1; Perylene; Structure-Activity Relationship | 1998 |
The role of oxygen in the antiviral activity of hypericin and hypocrellin.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Antiviral Agents; Horses; Infectious Anemia Virus, Equine; Light; Luminescent Measurements; Microbial Sensitivity Tests; Oxygen; Perylene; Phenol; Photochemistry; Quinones; Singlet Oxygen | 1998 |
Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro.
Topics: Anthracenes; Glioma; Humans; Perylene; Protein Kinase C; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1996 |
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Nucleus; Cell Size; Cell Survival; Cysteine Proteinase Inhibitors; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Activation; Enzyme Precursors; HeLa Cells; Humans; Light; Necrosis; Oligopeptides; Perylene; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Serpins; Viral Proteins | 1998 |
Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria.
Topics: Anthracenes; Apoptosis; Energy Metabolism; Enzyme Inhibitors; Glioma; Hexokinase; Humans; Hydrogen-Ion Concentration; Light; Mitochondria; Perylene; Radiation-Sensitizing Agents; Thymidine; Tumor Cells, Cultured | 1998 |
Photocytotoxic effect of pseudohypericin versus hypericin.
Topics: Anthracenes; Female; Fluorescence; Humans; Molecular Structure; Perylene; Photosensitivity Disorders; Subcellular Fractions; Tumor Cells, Cultured | 1998 |
Induction of differentiation of the human histocytic lymphoma cell line U-937 by hypericin.
Topics: Anthracenes; Cell Differentiation; Cell Division; Cell Size; Cells, Cultured; Esterases; Humans; Lymphoma; Nitroblue Tetrazolium; Oxidation-Reduction; Perylene; Phagocytosis; Tumor Cells, Cultured | 1998 |
In vitro and in vivo activation of hypericin with the incoherent light source PDT 1200 SOA (520-750 nm) and with solar simulated radiation (290-2500 nm).
Topics: Anthracenes; Cell Line; Humans; In Vitro Techniques; Keratinocytes; Light; Perylene; Photochemotherapy; Photosensitivity Disorders; Radiation-Sensitizing Agents | 1999 |
A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy.
Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Cell Nucleus; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, bcl-1; Genes, bcl-2; HL-60 Cells; Humans; Necrosis; Perylene; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents | 1999 |
Biochemical activities of extracts from Hypericum perforatum L. 1st Communication: inhibition of dopamine-beta-hydroxylase.
Topics: Anthracenes; Dopamine beta-Hydroxylase; Enzyme Inhibitors; Ericales; Hydrogen Peroxide; Monophenol Monooxygenase; Oxidants; Perylene; Plant Extracts; Tyrosine Decarboxylase | 1999 |
Biochemical activities of extracts from Hypericum perforatum L. 2nd Communication: inhibition of metenkephaline- and tyrosine-dimerization.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Depression, Chemical; Dimerization; Enkephalin, Methionine; Enzyme Inhibitors; Ericales; Horseradish Peroxidase; Hydrogen Peroxide; Hydrogen-Ion Concentration; Oxidants; Peroxidase; Perylene; Phenols; Plant Extracts; Tyrosine | 1999 |
Biochemical activities of extracts from Hypericum perforatum L. 4th Communication: influence of different cultivation methods.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Dimerization; Enzyme Inhibitors; Ericales; Horseradish Peroxidase; Indoleacetic Acids; Oxidation-Reduction; Perylene; Phenols; Plant Extracts; Tyrosine | 1999 |
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin.
Topics: Anthracenes; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Perylene; Photochemotherapy; Poly(ADP-ribose) Polymerases; Radiation-Sensitizing Agents; Signal Transduction | 1999 |
Confluence dependent resistance to photo-activated hypericin in HeLa cells.
Topics: Anthracenes; Antineoplastic Agents; Cell Count; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Perylene; Photochemistry | 1999 |
Subcellular distributions and excited-state processes of hypericin in neurons.
Topics: Animals; Anthracenes; Cells, Cultured; Hippocampus; Microscopy, Fluorescence; Neurons; Perylene; Photosensitizing Agents; Rats; Subcellular Fractions | 1999 |
Determination of hypericin in plasma by high-performance liquid chromatography.
Topics: Anthracenes; Antidepressive Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Male; Perylene; Sensitivity and Specificity; Spectrometry, Fluorescence | 1999 |
The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Anthracenes; Dimyristoylphosphatidylcholine; Lipid Bilayers; Membrane Fluidity; Membrane Potentials; Mice; Perylene; Phenol; Photochemistry; Photosensitizing Agents; Proteolipids; Quinones; Sodium-Potassium-Exchanging ATPase; Spectrometry, Fluorescence | 1999 |
Hypericin as a non-antioxidant inhibitor of NF-kappa B.
Topics: Animals; Anthracenes; Cell Line; HeLa Cells; Humans; Mice; NF-kappa B; Perylene; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
Photophysics of hypericin and hypocrellin A in complex with subcellular components: interactions with human serum albumin.
Topics: Anthracenes; Energy Transfer; Fluorescence Polarization; Humans; In Vitro Techniques; Macromolecular Substances; Perylene; Phenol; Photochemistry; Quinones; Serum Albumin, Bovine | 1999 |
Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat.
Topics: Animals; Anthracenes; Antidepressive Agents; Brain Stem; Cerebral Cortex; Diencephalon; Dopamine; Flavonoids; Male; Norepinephrine; Perylene; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Serotonin | 1999 |
Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin.
Topics: Acetylcholinesterase; Animals; Anthracenes; Antiviral Agents; Centrifugation, Density Gradient; Cross-Linking Reagents; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Guanidine; Perylene; Protein Denaturation; Protein Folding; Solubility; Spectrometry, Fluorescence; Torpedo | 1999 |
Antibacterial activity of hyperforin from St John's wort.
Topics: Anthracenes; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds; Cell Line; Dose-Response Relationship, Drug; Ericales; Humans; Perylene; Phloroglucinol; Terpenes | 1999 |
Sequence specific interaction of the photoactive drug hypericin depends on the structural arrangement and the stability of the structure containing its specific 5AG3 target: a resonance Raman spectroscopy study.
Topics: Anthracenes; DNA; Molecular Structure; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Perylene; Radiation-Sensitizing Agents; Spectrum Analysis, Raman; Structure-Activity Relationship | 1999 |
The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy.
Topics: Animals; Anthracenes; Antidepressive Agents; Conjunctiva; Disease Models, Animal; Disease Progression; Electroretinography; Fibroblasts; Injections; Perylene; Protein Kinase C; Rabbits; Retina; Vitrectomy; Vitreoretinopathy, Proliferative | 1999 |
The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity.
Topics: Animals; Anthracenes; Anti-Infective Agents; Cell Line; Cricetinae; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Emodin; Fluoroquinolones; Griseofulvin; Methoxsalen; Metronidazole; Micronucleus Tests; Perylene; Phenothiazines; Photosensitizing Agents; Tetracyclines; Ultraviolet Rays | 1999 |
In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model.
Topics: Anthracenes; Biological Transport; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Hypericum; Light; Perylene; Plant Extracts; Plants, Medicinal; Time Factors | 1999 |
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger.
Topics: Amiloride; Anthracenes; Antineoplastic Agents; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Omeprazole; Perylene; Radiation-Sensitizing Agents; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase | 1999 |
Bromohypericins are potent photoactive antiviral agents.
Topics: Animals; Anthracenes; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dogs; Herpesvirus 1, Human; Influenza A virus; Perylene; Photosensitizing Agents; Structure-Activity Relationship; Vero Cells | 1999 |
Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway.
Topics: 3T3 Cells; Animals; Anthracenes; Apoptosis; Bongkrekic Acid; Caspase 3; Caspases; Cell Line; Cell Membrane Permeability; Cyclosporine; Dose-Response Relationship, Radiation; Enzyme Activation; Fibroblasts; Flow Cytometry; Fluoresceins; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Membrane Potentials; Mice; Microscopy, Confocal; Mitochondria; Perylene; Phosphatidylserines; Photosensitivity Disorders; Proto-Oncogene Proteins c-bcl-2; Time Factors | 1999 |
Photocytotoxicity of protohypericin after photoconversion to hypericin.
Topics: Anthracenes; HeLa Cells; Humans; Perylene; Photosensitizing Agents | 1999 |
Phenanthrenequinone antiretroviral agents.
Topics: Animals; Anthracenes; Antiviral Agents; Horses; Infectious Anemia Virus, Equine; Perylene; Phenanthrenes; Photochemistry; Structure-Activity Relationship | 2000 |
In vitro and in vivo evaluation of hypericin for photodynamic therapy of equine sarcoids.
Topics: Animals; Anthracenes; Cell Line; Equidae; Female; Horse Diseases; Horses; Humans; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Skin Neoplasms | 2000 |
Strategies for evaluation of enveloped virus inactivation in red cell concentrates using hypericin.
Topics: Animals; Anthracenes; Anti-HIV Agents; Antiviral Agents; Cattle; Cell-Free System; Diarrhea Viruses, Bovine Viral; Erythrocytes; HIV-1; Humans; Light; Perylene; Radiation-Sensitizing Agents | 2000 |
Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures.
Topics: Anthracenes; Cells, Cultured; Culture Techniques; Hypericum; Mannans; Perylene; Plant Shoots; Plants, Medicinal | 2000 |
Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: potential for treatment of T cell-mediated diseases.
Topics: Animals; Anthracenes; Apoptosis; Cell Membrane; Cytoplasmic Granules; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Exocytosis; Immune System Diseases; Immunosuppressive Agents; Ligands; Light; Mice; Perylene; Phospholipids; Phosphorylation; Receptors, Tumor Necrosis Factor; T-Lymphocytes, Cytotoxic | 2000 |
Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Cell Differentiation; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Perylene | 1999 |
Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model.
Topics: Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Kidney; Liver; Mice; Mice, Inbred DBA; Muscles; Neoplasms, Experimental; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Skin; Spleen; Survival Analysis; Time Factors; Tissue Distribution; Treatment Outcome; Tumor Cells, Cultured | 2000 |
Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats.
Topics: Animals; Anthracenes; Anti-Anxiety Agents; Cerebellum; Electrophysiology; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hypericum; Male; Motor Activity; Patch-Clamp Techniques; Perylene; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 2000 |
Tamoxifen-resistant glioma-cell sub-populations are characterized by increased migration and proliferation.
Topics: Anthracenes; Antineoplastic Agents, Hormonal; Cell Division; Cell Movement; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glioma; Humans; Perylene; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 2000 |
Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10.
Topics: Anthracenes; Apoptosis; Chlamydophila pneumoniae; Dose-Response Relationship, Immunologic; Humans; Immunity, Innate; Interleukin-10; Interleukin-12; Leukocytes, Mononuclear; Methoxsalen; Perylene; Tumor Necrosis Factor-alpha | 2000 |
Hypericin photosensitization of tumor and metastatic cell lines of human prostate.
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Humans; Male; Neoplasm Metastasis; Perylene; Photochemotherapy; Prostatic Neoplasms; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2000 |
Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids.
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Dopamine beta-Hydroxylase; Enzyme Inhibitors; Flavonoids; Hypericum; Norepinephrine; Oxygen; Perylene; Plant Extracts; Plants, Medicinal | 2000 |
Investigation of the absorption of hypericin into the skin of hairless mice.
Topics: Administration, Cutaneous; Animals; Anthracenes; Female; Male; Mice; Mice, Hairless; Perylene; Radiation-Sensitizing Agents; Skin Absorption | 2000 |
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chlorogenic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes | 2000 |
Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin.
Topics: Administration, Intravesical; Anthracenes; Carcinoma in Situ; Carcinoma, Transitional Cell; Fluorescence; Humans; Perylene; Photosensitizing Agents; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2000 |
Intratumoral hypericin and KTP laser therapy for transplanted squamous cell carcinoma.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Squamous Cell; Injections, Intralesional; Laser Therapy; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Perylene; Photochemotherapy; Pilot Projects; Tumor Cells, Cultured | 2000 |
Hypericin and photodynamic therapy decreases human pancreatic cancer in vitro and in vivo.
Topics: Animals; Anthracenes; Antineoplastic Agents; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Perylene; Photochemotherapy; Tissue Distribution; Tumor Cells, Cultured | 2000 |
Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John's Wort).
Topics: Animals; Anthracenes; Antidepressive Agents; Cataract; Cattle; Crystallins; Humans; Hypericum; In Vitro Techniques; Oxidation-Reduction; Perylene; Photochemistry; Plants, Medicinal | 2000 |
St John's wort, a herbal antidepressant, activates the steroid X receptor.
Topics: Animals; Anthracenes; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Bridged Bicyclo Compounds; Corticosterone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Histone Acetyltransferases; Humans; Hypericum; Mice; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Perylene; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Protein Binding; Receptors, Steroid; Rifampin; Terpenes; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
[Flavonoid and dianthranoid levels of the St.-John's-wort flowering tops].
Topics: Anthracenes; Chromatography, High Pressure Liquid; Colorimetry; Flavonoids; Hypericum; ortho-Aminobenzoates; Perylene; Plants, Medicinal; Spectrophotometry, Ultraviolet | 2000 |
Photocytotoxicity of hypericin in normoxic and hypoxic conditions.
Topics: Anthracenes; Cell Hypoxia; Cell Survival; Darkness; Glass; Humans; Light; Neutral Red; Perylene; Polystyrenes; Radiation-Sensitizing Agents; Skin Neoplasms; Tumor Cells, Cultured | 2000 |
Effect of pH on the fluorescence and absorption spectra of hypericin in reverse micelles.
Topics: Anthracenes; Hydrogen-Ion Concentration; In Vitro Techniques; Micelles; Models, Molecular; Perylene; Photochemistry; Spectrometry, Fluorescence; Spectrophotometry | 2000 |
Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection.
Topics: Anthracenes; Chromatography, Liquid; Perylene; Pharmaceutical Preparations; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2000 |
The uptake, location and fluorescence of hypericin in bovine intact lens.
Topics: Absorption; Animals; Anthracenes; Cattle; Crystallins; Fluorescence; In Vitro Techniques; Lens, Crystalline; Perylene; Solubility; Solutions; Tissue Distribution | 2000 |
Liposome binding constants and singlet oxygen quantum yields of hypericin, tetrahydroxy helianthrone and their derivatives: studies in organic solutions and in liposomes.
Topics: Anthracenes; Hematoporphyrin Derivative; Liposomes; Mass Spectrometry; Methanol; Oxygen; Perylene; Phosphatidylcholines; Rose Bengal; Singlet Oxygen; Solutions | 2000 |
Photochemical effects and hypericin photosensitized processes in collagen.
Topics: Animals; Anthracenes; Cattle; Collagen; Fluorescence; Gelatin; Lasers; Perylene; Photochemistry; Radiation-Sensitizing Agents; Solutions | 2001 |
Hypocrellin and hypericin-induced phototoxicity of HL-60 cells: apoptosis or necrosis?
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Drugs, Chinese Herbal; HL-60 Cells; Humans; Necrosis; Perylene; Phenol; Photosensitizing Agents; Quinones | 2000 |
Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat.
Topics: Animals; Anthracenes; Antidepressive Agents; Brain Chemistry; Catecholamines; Corticosterone; Dopamine Antagonists; Haloperidol; Hypericum; Male; Neurosecretory Systems; Perylene; Piperazines; Plant Extracts; Plants, Medicinal; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2000 |
Absorbance data of hypericin and pseudohypericin used as reference compounds for medicinal plant analysis.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Perylene; Plants, Medicinal; Reference Standards; Solvents; Spectrophotometry, Ultraviolet | 2001 |
Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates.
Topics: Animals; Anthracenes; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Half-Life; Injections, Intravenous; Macaca mulatta; Male; Perylene; Time Factors | 2001 |
Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy.
Topics: Animals; Anthracenes; Blood Vessels; Dose-Response Relationship, Drug; Female; Fluorescein; Hydralazine; Injections, Intravenous; Lymphoma; Mice; Mice, Inbred DBA; Niacinamide; Oxygen; Perylene; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms; Vasodilator Agents | 2001 |
Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort).
Topics: Anthracenes; Hypericum; Perylene; Plant Leaves; Plants, Medicinal; Seasons; Spectrophotometry | 2001 |
Is the excited-state H-atom transfer in hypericin concerted?
Topics: Anthracenes; Antiviral Agents; Chelating Agents; Hydrogen; Hydrogen-Ion Concentration; Micelles; Naphthalenes; Perylene; Photochemistry; Protons; Terbinafine | 2001 |
Solvatochromic effects in the electronic absorption and nuclear magnetic resonance spectra of hypericin in organic solvents and in lipid bilayers.
Topics: Anthracenes; Lipid Bilayers; Magnetic Resonance Spectroscopy; Perylene; Photochemistry; Photosensitizing Agents; Solvents; Spectrometry, Fluorescence; Spectrophotometry | 2001 |
Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8.
Topics: Anthracenes; Antibodies, Monoclonal; Antigens, CD; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Division; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; In Situ Nick-End Labeling; Jurkat Cells; Light; Membrane Glycoproteins; Oligopeptides; Paclitaxel; Perylene; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2001 |
In vivo photodynamic activity of hypericin in transitional cell carcinoma bladder tumors.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Female; Injections, Intraperitoneal; Neoplasm Recurrence, Local; Neoplasms, Experimental; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tissue Distribution; Treatment Outcome; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2001 |
Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent.
Topics: Anthracenes; Carotenoids; Chromatography, High Pressure Liquid; Humans; K562 Cells; Magnetic Resonance Spectroscopy; Molecular Structure; Oxygen; Perylene; Photochemistry; Photosensitizing Agents; Porphyrins; Protoporphyrins; Singlet Oxygen; Tumor Cells, Cultured; Vitamin A | 2001 |
Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hypericum; Perylene; Pigments, Biological; Plant Extracts; Plant Leaves; Plant Stems; Plants, Medicinal; Sunlight | 2001 |
Synergistic effect of photodynamic therapy with hypericin in combination with hyperthermia on loss of clonogenicity of RIF-1 cells.
Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Cell Death; Combined Modality Therapy; Drug Synergism; Fibrosarcoma; Hyperthermia, Induced; Microscopy, Confocal; Microscopy, Phase-Contrast; Perylene; Photochemotherapy; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Tumor Cells, Cultured | 2001 |
Hypericin: an answer for safer blood?
Topics: Anthracenes; Antiviral Agents; Blood Preservation; Blood-Borne Pathogens; Clinical Trials as Topic; Cytomegalovirus; Hepatitis B; Hepatitis C; HIV; HIV Infections; Humans; Perylene; Sterilization | 1995 |
Light-induced photoactivation of hypericin inhibits cellular growth in pituitary adenoma cell line AtT20/D16v-F2 (hypericin inhibits cellular growth of AtT20/D16v-F2).
Topics: Adenoma; Animals; Anthracenes; Apoptosis; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Radiation; HL-60 Cells; Humans; Light; Mice; Perylene; Photosensitizing Agents; Pituitary Neoplasms; Protein Kinase C; Tumor Cells, Cultured | 2001 |
Photosensitive chemical and laser light treatments decrease epizootic hemorrhagic disease virus associated with in vitro produced bovine embryos.
Topics: Animals; Anthracenes; Cattle; Cattle Diseases; Cell Line; Cricetinae; Cytopathogenic Effect, Viral; Female; Fertilization in Vitro; Hematoporphyrins; Hemorrhagic Disease Virus, Epizootic; Lasers; Perylene; Photochemistry; Photochemotherapy; Pregnancy; Reoviridae Infections; Zygote | 2001 |
Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model.
Topics: Animals; Anthracenes; Antineoplastic Agents; Dermatitis, Phototoxic; Disease Models, Animal; Female; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Perylene; Photochemotherapy; Protein Binding; Skin; Time Factors; Tissue Distribution; Treatment Outcome; Tumor Cells, Cultured | 2001 |
Effect of St. John's wort on free radical production.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Free Radicals; Humans; Hypericum; Indicators and Reagents; Perylene; Phloroglucinol; Placenta; Plant Extracts; Plants, Medicinal; Pregnancy; Superoxides; Terpenes; Veins | 2001 |
Photo-activation of hypericin with low doses of light promotes apparent photo-resistance in human histiocytic lymphoma U937 cells.
Topics: Anthracenes; Apoptosis; Cell Death; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; HSP70 Heat-Shock Proteins; Humans; Necrosis; Perylene; Phototherapy; Radiation Injuries; U937 Cells | 2001 |
Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Ethanol; Excitatory Amino Acid Antagonists; Female; Hypericum; Liver; Male; Methanol; Microsomes; Perylene; Phenobarbital; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Sex Factors; Solvents; Terpenes | 2001 |
Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypericum; Male; Neurotransmitter Agents; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes | 2001 |
Batch-to-batch reproducibility of St. John's wort preparations.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Reproducibility of Results; Terpenes | 2001 |
Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anthracenes; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antioxidants; Biflavonoids; Catechin; Corticosterone; Endocrine System; Exploratory Behavior; Hypericum; Imipramine; Luteinizing Hormone; Male; Organ Size; Perylene; Pituitary Gland; Plant Extracts; Proanthocyanidins; Rats; Rats, Inbred Strains; Seminal Vesicles; Swimming | 2001 |
In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters.
Topics: Animals; Anthracenes; Antidepressive Agents; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Dopamine Plasma Membrane Transport Proteins; Flavonoids; Hypericum; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Perylene; Phloroglucinol; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neuropeptide Y; Receptors, Serotonin; Receptors, sigma; Terpenes | 2001 |
Interleukin-6 involvement in antidepressant action of Hypericum perforatum.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Diencephalon; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Hypericum; Immune System; Interleukin-6; Male; Mice; Mice, Knockout; Perylene; Phloroglucinol; Plant Extracts; Rutin; Serotonin; Swimming; Terpenes; Tryptophan | 2001 |
St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anthracenes; Antidepressive Agents; Arginine Vasopressin; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP Response Element-Binding Protein; Drug Administration Schedule; Glutamate Decarboxylase; Hippocampus; Hypericum; Hypothalamo-Hypophyseal System; Imipramine; In Situ Hybridization; Isoenzymes; Locus Coeruleus; Male; Paraventricular Hypothalamic Nucleus; Perylene; Pituitary Gland; Plants, Medicinal; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reference Values; Restraint, Physical; RNA, Messenger; Stress, Psychological; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2001 |
Anti-cancer activities of hypericin in the dark.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Survival; Darkness; Female; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Perylene; Photochemotherapy; Tumor Cells, Cultured | 2001 |
Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antioxidants; Cell Death; Cell Division; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Rats; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2001 |
Different pathways mediate cytochrome c release after photodynamic therapy with hypericin.
Topics: Animals; Anthracenes; Caspase 3; Caspases; Cell Death; Cell Line; Cytochrome c Group; Enzyme Activation; Enzyme Precursors; Genes, bcl-2; Hybridomas; Membrane Potentials; Mice; Mitochondria; Perylene; Photochemotherapy; Poly(ADP-ribose) Polymerases; Rats; Serpins; Transfection; Viral Proteins | 2001 |
Hypericin derivatives: substituent effects on radical-anion formation.
Topics: Anions; Anthracenes; Electron Spin Resonance Spectroscopy; Electron Transport; Free Radicals; In Vitro Techniques; Molecular Structure; Oxidation-Reduction; Perylene; Photochemistry; Photosensitizing Agents | 2001 |
Identification of a vibrational frequency corresponding to H-atom translocation in hypericin.
Topics: Anthracenes; In Vitro Techniques; Perylene; Photochemistry; Photosensitizing Agents; Spectrophotometry, Infrared | 2001 |
In vitro study of the photocytotoxicity of some hypericin analogs on different cell lines.
Topics: Anthracenes; Blood Proteins; Chromatography, High Pressure Liquid; HeLa Cells; Humans; In Vitro Techniques; Perylene; Photochemistry; Photosensitizing Agents; Protein Binding; Structure-Activity Relationship; Subcellular Fractions; Tumor Cells, Cultured | 2001 |
Interaction of hypericin with serum albumins: surface-enhanced Raman spectroscopy, resonance Raman spectroscopy and molecular modeling study.
Topics: Animals; Anthracenes; Cattle; Humans; Hydrogen Bonding; In Vitro Techniques; Models, Molecular; Molecular Conformation; Perylene; Photochemistry; Photosensitizing Agents; Rats; Serum Albumin; Spectrum Analysis, Raman | 2001 |
Spectroscopic study of visible-light effects on hypericin-lens proteins systems.
Topics: Animals; Anthracenes; Cattle; Crystallins; In Vitro Techniques; Light; Perylene; Photochemistry; Photosensitizing Agents; Protein Binding; Spectrometry, Fluorescence; Spectrophotometry | 2001 |
The structure of hypericin in solution. Searching for hypericin's 1,6 tautomer.
Topics: Anthracenes; Isomerism; Magnetic Resonance Spectroscopy; Perylene; Photosensitizing Agents; Solutions; Spectrophotometry | 2001 |
Toward hypericin-derived potential photodynamic therapy agents.
Topics: Anthracenes; In Vitro Techniques; Magnetic Resonance Spectroscopy; Oxygen; Perylene; Photochemistry; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; Superoxides | 2001 |
Tumor cell toxicity of hypericin and related analogs.
Topics: Anthracenes; Antineoplastic Agents; Humans; Oxygen; Perylene; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; Tumor Cells, Cultured | 2001 |
Tumor-specific and photodependent cytotoxicity of hypericin in the human LNCaP prostate tumor model.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Death; Humans; Male; Mice; Mice, Nude; Perylene; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Tumor Cells, Cultured | 2001 |
Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts.
Topics: Algorithms; Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Drug Storage; Flavonoids; Hypericum; Parasympatholytics; Perylene; Phloroglucinol; Plant Extracts; Solvents; Sunlight | 2001 |
Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).
Topics: Anthracenes; Antigens, Neoplasm; Catalysis; DNA Damage; DNA Fragmentation; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Antagonism; Enzyme Inhibitors; HL-60 Cells; Humans; Hypericum; Isoenzymes; Perylene; Phytotherapy; Plants, Medicinal; Topoisomerase II Inhibitors | 2001 |
Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Solutions; Terpenes | 2001 |
Chemical and pharmacological evaluation of Hypericum perforatum extracts.
Topics: Animals; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Free Radical Scavengers; Hippocampus; Hypericum; Male; Perylene; Phloroglucinol; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Terpenes | 2000 |
Induction of apoptosis by Hypericin through activation of caspase-3 in human carcinoma cells.
Topics: Anthracenes; Apoptosis; Biological Transport; Caspase 3; Caspases; Cell Membrane; Cell Size; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Situ Nick-End Labeling; Perylene; Phosphatidylserines; Poly(ADP-ribose) Polymerases; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2001 |
Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Electrolytes; Electrophoresis, Capillary; Hypericum; Molecular Structure; Osmotic Pressure; Perylene; Phloroglucinol; Plant Extracts; Reproducibility of Results; Rheology; Solvents; Terpenes | 2002 |
Photodynamic therapy of murine fibrosarcoma with topical and systemic administration of hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Fibrosarcoma; Light; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Molecular Structure; Perylene; Photochemotherapy; Survival Analysis; Tumor Cells, Cultured | 2001 |
Effects of photodynamic therapy with hypericin in mice bearing highly invasive solid tumors.
Topics: Adenocarcinoma; Animals; Anthracenes; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cytokines; Humans; Light; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured | 2000 |
Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines.
Topics: Adenocarcinoma; Anthracenes; Carcinoma in Situ; Colonic Neoplasms; Female; Glioblastoma; Humans; Perylene; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2001 |
A study of hypericin-induced teratogenicity during organogenesis using a whole rat embryo culture model.
Topics: Animals; Anthracenes; Antidepressive Agents; Culture Techniques; Embryonic and Fetal Development; Perylene; Rats; Rats, Sprague-Dawley; Teratogens | 2001 |
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.
Topics: Adenocarcinoma; Anthracenes; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blotting, Western; Caco-2 Cells; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Humans; Hypericum; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Perylene; Protein Kinase C; Rhodamine 123; Ritonavir; Time Factors; Tumor Cells, Cultured; Verapamil | 2001 |
Transferrin-mediated targeting of hypericin embedded in sterically stabilized PEG-liposomes.
Topics: Anthracenes; Cell Survival; Drug Delivery Systems; Female; HeLa Cells; Humans; Liposomes; Perylene; Polyethylene Glycols; Radiation-Sensitizing Agents; Transferrin | 2002 |
Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Line; Cell Membrane; Cell Size; Cell Survival; DNA, Neoplasm; Enzyme Activation; Humans; Mucous Membrane; Nasopharyngeal Neoplasms; Perylene; Phenol; Phosphatidylserines; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Quinones; Tumor Cells, Cultured | 2001 |
[Hyperici herba (Hypericum perforatum L].
Topics: Anthracenes; Drug Interactions; Hypericum; Molecular Structure; Perylene; Phytotherapy; Structure-Activity Relationship | 2001 |
Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Female; Models, Animal; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Rats; Tissue Distribution; Treatment Outcome; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2002 |
[Experimental cultivation of Hypericum perforatum L. in Bratislava].
Topics: Anthracenes; Hypericum; Perylene; Plant Extracts; Plants, Medicinal | 2001 |
Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Humans; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Terpenes | 2001 |
The effect of quercetin on light-induced cytotoxicity of hypericin.
Topics: Anthracenes; Cell Survival; Drug Interactions; HL-60 Cells; Humans; Light; Perylene; Photochemistry; Quercetin; Radiation-Sensitizing Agents; Reactive Oxygen Species | 2001 |
New aspect of photodynamic diagnosis of bladder tumors: fluorescence cytology.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystitis; Cytophotometry; Humans; Microscopy, Fluorescence; Middle Aged; Neoplasm Staging; Perylene; Photosensitizing Agents; Pilot Projects; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2002 |
Molecular aspects of photodynamic therapy: low energy pre-sensitization of hypericin-loaded human endometrial carcinoma cells enhances photo-tolerance, alters gene expression and affects the cell cycle.
Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Biological Transport; Carcinoma; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; HSP70 Heat-Shock Proteins; Humans; Necrosis; Perylene; Photochemotherapy; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents | 2002 |
Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.
Topics: Animals; Anthracenes; Apoptosis; Blood Vessels; Cell Nucleus; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Radiation; Fas Ligand Protein; fas Receptor; Female; Fibrosarcoma; In Situ Nick-End Labeling; Kinetics; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Neoplasm Transplantation; Perylene; Photochemotherapy; Photosensitizing Agents | 2002 |
Phototoxic and apoptosis-inducing capacity of pseudohypericin.
Topics: Anthracenes; Apoptosis; Cell Division; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Hypericum; Jurkat Cells; Molecular Structure; Perylene | 2002 |
Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus.
Topics: Animals; Anthracenes; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Dopamine; Hippocampus; Hypericum; Hypothalamus; Imipramine; Kinetics; Male; Norepinephrine; Perylene; Rats; Serotonin | 2002 |
Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.
Topics: Alanine Transaminase; Animals; Anthracenes; Antidepressive Agents; Body Weight; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Enzyme Induction; Hypericum; Isoenzymes; Liver; Male; Mice; Perylene; Phloroglucinol; Plant Preparations; Terpenes | 2002 |
Determining hyperforin and hypericin content in eight brands of St. John's wort.
Topics: Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Dosage Forms; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2002 |
The separation of hypericine and pseudohypericine from Hypericum perforatum L.
Topics: Anthracenes; Chromatography; Chromatography, Thin Layer; Countercurrent Distribution; Hypericum; Magnetic Resonance Spectroscopy; Methanol; Perylene; Solvents; Spectrophotometry, Ultraviolet; Ultrasonics | 2002 |
[Studies on synthesis and anti-HIV RT activity of hypericin and ethylhypericin].
Topics: Anthracenes; Antiviral Agents; Enzyme Inhibitors; HIV Reverse Transcriptase; HIV-1; Perylene | 1998 |
Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspases; Cytochrome c Group; DNA Fragmentation; Enzyme Activation; Flow Cytometry; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Membrane Potentials; Microscopy, Electron; Mitochondria; Perylene; Phenol; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Quinones; Reactive Oxygen Species; Tumor Cells, Cultured | 2002 |
Potentiation of hypericin and hypocrellin-induced phototoxicity by omeprazole.
Topics: Anthracenes; Antineoplastic Agents; Antiviral Agents; Cell Survival; Drug Synergism; HL-60 Cells; Humans; Omeprazole; Perylene; Phenol; Photosensitizing Agents; Quinones | 1999 |
Hypericin-based fluorescence diagnosis of bladder carcinoma.
Topics: Anthracenes; Carcinoma in Situ; Carcinoma, Papillary; Cystoscopy; Humans; Microscopy, Fluorescence; Perylene; Radiation-Sensitizing Agents; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2002 |
Severe phototoxic reaction to laser treatment in a patient taking St John's Wort.
Topics: Anthracenes; Antidepressive Agents; Dermatitis, Phototoxic; Face; Female; Humans; Hypericum; Keratosis; Laser Therapy; Leg; Middle Aged; Perylene; Phytotherapy; Plant Preparations; Plastic Surgery Procedures; Postoperative Complications; Radiation-Sensitizing Agents | 2001 |
Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells.
Topics: Anthracenes; Antineoplastic Agents; Arabidopsis Proteins; Blotting, Western; Caspase 8; Caspase 9; Caspases; Cell Differentiation; Cells, Cultured; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Fatty Acid Desaturases; Flow Cytometry; Humans; Membrane Glycoproteins; Membrane Potentials; Mitochondria; Perylene; Photochemotherapy; Time Factors; Tumor Cells, Cultured | 2002 |
Influence of structure of human, rat, and bovine serum albumins on binding properties of photoactive drug hypericin.
Topics: Animals; Anthracenes; Cattle; Humans; Models, Molecular; Perylene; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Radiation-Sensitizing Agents; Rats; Serum Albumin; Spectrometry, Fluorescence | 2002 |
Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort).
Topics: Anthracenes; Cells, Cultured; Cyclopentanes; Hypericum; Oxylipins; Perylene | 2002 |
Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy.
Topics: Anthracenes; Cytokines; Flow Cytometry; Humans; Interleukin-10; Interleukin-8; Nasopharyngeal Neoplasms; Perylene; Photochemotherapy; Tumor Cells, Cultured | 2002 |
Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis.
Topics: Anthracenes; Apoptosis; CDC2 Protein Kinase; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; HeLa Cells; Humans; Kinetics; Mitosis; Nocodazole; Paclitaxel; Perylene; Photochemotherapy; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Vinblastine | 2002 |
Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?
Topics: Acetylcholinesterase; Animals; Anthracenes; Bungarus; Centrifugation, Density Gradient; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Kinetics; Micelles; Microchemistry; Perylene; Phospholipids; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Temperature; Time Factors | 2002 |
Effect of acetazolamide on hypericin photocytotoxicity.
Topics: Acetazolamide; Anthracenes; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Cell Division; Cell Survival; Dermatitis, Phototoxic; Drug Interactions; HL-60 Cells; Humans; Hydrogen-Ion Concentration; Perylene | 2002 |
Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Cytochrome c Group; Humans; Intracellular Membranes; Lysosomes; Membrane Potentials; Microscopy, Electron; Mitochondria; Nasopharyngeal Neoplasms; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Subcellular Fractions; Tissue Distribution; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 2002 |
Toward the molecular flashlight: preparation, properties, and photophysics of a hypericin-luciferin tethered molecule.
Topics: Anthracenes; Firefly Luciferin; Perylene; Photochemistry; Photochemotherapy; Photosensitizing Agents | 2002 |
MEK and ERK inhibitors enhance the anti-proliferative effect of interferon-alpha2b.
Topics: Anthracenes; CD4-Positive T-Lymphocytes; Cell Cycle; Cell Division; Drug Synergism; Enzyme Inhibitors; Flavonoids; Humans; Interferon alpha-2; Interferon-alpha; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Perylene; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Proteins; Signal Transduction; Time Factors | 2002 |
Solubility of hypericin in methanol and methanol-pyridine.
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Methanol; Perylene; Pyridines; Reference Standards; Solubility; Solvents; Spectrophotometry, Ultraviolet | 2002 |
Relative quantification of mRNA levels in Jurkat T cells with RT-real time-PCR (RT-rt-PCR): new possibilities for the screening of anti-inflammatory and cytotoxic compounds.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Catechin; CD4-Positive T-Lymphocytes; Cell Survival; Gene Expression Regulation; Humans; Jurkat Cells; Perylene; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry.
Topics: Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, Liquid; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Reproducibility of Results; Terpenes | 2002 |
Photobleaching of hypericin bound to human serum albumin, cultured adenocarcinoma cells and nude mice skin.
Topics: Animals; Anthracenes; Humans; Mice; Mice, Nude; Perylene; Photochemistry; Serum Albumin; Skin; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2002 |
Wavelength-dependent properties of photodynamic therapy using hypericin in vitro and in an animal model.
Topics: Animals; Anthracenes; In Vitro Techniques; Mice; Models, Animal; Perylene; Photochemotherapy; Tumor Cells, Cultured | 2002 |
Antivascular tumor eradication by hypericin-mediated photodynamic therapy.
Topics: Animals; Anthracenes; Blood Vessels; Disease Models, Animal; Female; Laser Therapy; Mice; Mice, Inbred C3H; Perylene; Photochemotherapy; Photosensitizing Agents; Sarcoma, Experimental; Time Factors | 2002 |
An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem).
Topics: Anthracenes; Bridged Bicyclo Compounds; Culture Techniques; Environment, Controlled; Hydroponics; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2002 |
Antagonist effect of pseudohypericin at CRF1 receptors.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Calcitonin; CHO Cells; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Perylene; Phloroglucinol; Receptors, Corticotropin-Releasing Hormone; Terpenes; Transfection | 2003 |
Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole.
Topics: Amiloride; Anthracenes; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ethylmaleimide; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Leukemia; Light; Omeprazole; Perylene; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2002 |
Clinic at the health food store? Employee recommendations and product analysis.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Consumer Product Safety; Depression; Drug Labeling; Employee Performance Appraisal; Food, Organic; Health Knowledge, Attitudes, Practice; Humans; Hypericum; Perylene; Surveys and Questionnaires | 2003 |
Effect of hypericin on confocal imaging of Ca2+ signaling in cultured human retinal pigment epithelium.
Topics: Adult; Aniline Compounds; Anthracenes; Calcium Channels; Calcium Signaling; Cell Communication; Fluorescent Dyes; Gap Junctions; Humans; Microscopy, Confocal; Perylene; Pigment Epithelium of Eye; Protein Kinase C; Retina; Xanthenes | 2001 |
[Dangerous interaction of St. John's wort with chemotherapy?].
Topics: Anthracenes; Antineoplastic Agents; Bridged Bicyclo Compounds; Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Terpenes | 2003 |
Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells.
Topics: Amyloid beta-Peptides; Animals; Anthracenes; Apoptosis; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydroxyl Radical; Iron; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Perylene; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 2002 |
Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation.
Topics: Animals; Anthracenes; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Kinetics; Microscopy, Fluorescence; Neoplasm Transplantation; Perylene; Photosensitizing Agents; Rats; Rats, Inbred F344; Time Factors; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium | 2003 |
The correlation between hydrophilicity of hypericins and helianthrone: internalization mechanisms, subcellular distribution and photodynamic action in colon carcinoma cells.
Topics: Animals; Anthracenes; Colonic Neoplasms; Endocytosis; Flow Cytometry; Mice; Perylene; Photochemotherapy; Photosensitizing Agents; Subcellular Fractions; Tumor Cells, Cultured | 2002 |
[Methyl-D3]2hypericin as internal standard for quantification in human plasma.
Topics: Anthracenes; Deuterium; Humans; Molecular Structure; Perylene; Reference Standards; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2003 |
Mood-enhancing antidepressant St. John's wort inhibits the activation of human immunodeficiency virus gene expression by ultraviolet light.
Topics: Anthracenes; Antidepressive Agents; Butyrates; Chloramphenicol; Dose-Response Relationship, Drug; Gene Expression Regulation, Viral; Genes, Reporter; Ginkgo biloba; HeLa Cells; HIV; Humans; Hypericum; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Perylene; Time Factors; Transfection; Ultraviolet Rays | 2002 |
Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Dose-Response Relationship, Radiation; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Perylene; Photochemotherapy; Photosensitizing Agents; Time Factors; Tumor Cells, Cultured | 2003 |
Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Biflavonoids; Biological Availability; Catechin; Chromatography, High Pressure Liquid; Drug Synergism; Male; Perylene; Phytotherapy; Plant Extracts; Proanthocyanidins; Quercetin; Rats; Rats, Sprague-Dawley; Solubility | 2003 |
Biodistribution and photodynamic therapy with hypericin in a human NPC murine tumor model.
Topics: Animals; Anthracenes; Carcinoma, Squamous Cell; Cell Division; Humans; Kinetics; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Nasopharyngeal Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Protein Kinase C; Tissue Distribution; Transplantation, Heterologous | 2003 |
Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems.
Topics: Anthracenes; Chemical Phenomena; Chemistry, Physical; Hypericum; Perylene; Phenols; Plant Extracts; Solubility; Water | 2003 |
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Camptothecin; Cell Line; Glioblastoma; Humans; Irinotecan; Naphthalenes; Perylene; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 2003 |
Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Female; Hypericum; Male; Mice; Mice, Inbred Strains; Motor Activity; Perylene; Phloroglucinol; Physical Exertion; Plant Extracts; Rats; Rats, Inbred Strains; Swimming; Terpenes | 2003 |
[Induction of callus of Hypericum perforatum L. and qualitative identification of active constituents of its callus].
Topics: Anthracenes; Culture Media; Culture Techniques; Hypericum; Perylene; Plant Leaves; Plants, Medicinal | 2001 |
Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St. John's wort (Hypericum perforatum L.).
Topics: Amino Acid Sequence; Anthracenes; Base Sequence; Cells, Cultured; Chromatography, Liquid; DNA, Complementary; Hypericum; Mass Spectrometry; Molecular Sequence Data; Open Reading Frames; Perylene; Plant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid | 2003 |
Photosensitized structural modifications of the lens protein alpha-crystallin: do all modifications impair chaperone-like activity?
Topics: alpha-Crystallins; Animals; Anthracenes; Humans; Molecular Chaperones; Perylene; Photosensitizing Agents; Protein Conformation; Spectrophotometry | 2003 |
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
Topics: Annexin A5; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Astrocytes; Biflavonoids; Bridged Bicyclo Compounds; Caspases; Catechin; Cell Division; Cell Line, Tumor; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Proanthocyanidins; Terpenes | 2003 |
Comparison of hexamethylhypericin and tetrabromohypericin to hypericin for their in vivo efficacy as PDT tools.
Topics: Animals; Anthracenes; Antineoplastic Agents; Blood Proteins; Female; Humans; Lymphoma; Mice; Mice, Inbred DBA; Neoplasms, Experimental; Perylene; Photochemotherapy; Photosensitizing Agents; Protein Kinase C; Survival Rate; Treatment Outcome; Tumor Cells, Cultured | 2003 |
Does solvent influence the ground-state tautomeric population of hypericin?
Topics: Anthracenes; Fluorescence Polarization; Magnetic Resonance Spectroscopy; Molecular Structure; Perylene; Solvents; Spectrophotometry, Atomic; Stereoisomerism | 2003 |
Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.
Topics: Animals; Anthracenes; Butyrates; Carcinoma; Cell Cycle; Cell Differentiation; Colonic Neoplasms; Mice; Perylene; Photosensitizing Agents; Protoporphyrins; Pyrimidinones; Tumor Cells, Cultured | 2003 |
Hypericin as novel and promising photodynamic therapy tool: studies on intracellular accumulation capacity and growth inhibition efficiency.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Data Interpretation, Statistical; Dihematoporphyrin Ether; Mice; Mice, Inbred BALB C; Perylene; Photochemotherapy; Time Factors | 2003 |
Focal length variability and protein leakage as tools for measuring photooxidative damage to the lens.
Topics: Animals; Anthracenes; Cataract; Cattle; Lens, Crystalline; Light; Microscopy, Confocal; Oxidative Stress; Perylene; Proteins | 2003 |
Macro-microscopic fluorescence of human bladder cancer using hypericin fluorescence cystoscopy and laser confocal microscopy.
Topics: Anthracenes; Carcinoma, Transitional Cell; Enzyme Inhibitors; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; Lysosomes; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Perylene; Spectrometry, Fluorescence; Subcellular Fractions; Time Factors; Urinary Bladder Neoplasms | 2003 |
[Animal experimental studies on the influence of the photodynamic substance hypericin and of three flavones on cardiazol shock and electroshock].
Topics: Animals; Anthracenes; Electricity; Electroshock; Flavins; Flavones; Pentylenetetrazole; Perylene; Phototherapy | 1953 |
[Analytic studies on flavones. IV. Determination of hypericin and hyperoside in alcoholic extracts of plants].
Topics: Anthracenes; Flavones; Perylene; Plants; Quercetin | 1954 |
[On the therapy of depressive states with hypericin (Preliminary results with the experimental preparation Hyp. No 1)].
Topics: Anthracenes; Depression; Depressive Disorder; Perylene; Tranquilizing Agents | 1959 |
[Photometric determination of hypericin content in Hypericum].
Topics: Anthracenes; Hypericum; Perylene; Photometry; Plants | 1955 |
[Hypericin in the treatment of neurodermatoses].
Topics: Alopecia; Alopecia Areata; Anthracenes; Biological Products; Dermatology; Humans; Perylene; Pigments, Biological; Tranquilizing Agents | 1961 |
Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones.
Topics: Acetylcholinesterase; Algorithms; Anilino Naphthalenesulfonates; Animals; Anthracenes; Calorimetry, Differential Scanning; Catalysis; Circular Dichroism; Cross-Linking Reagents; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Enzyme Stability; Glutathione; Glycerol; Hot Temperature; Hydrolysis; Kinetics; Magnesium; Methylamines; Models, Theoretical; Perylene; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Sulfhydryl Reagents; Sulfinic Acids; Thermodynamics; Torpedo; Trypsin | 2003 |
Analysis of the hypericin and pseudohypericin content of commercially available St John's Wort preparations.
Topics: Anthracenes; Antidepressive Agents; Canada; Capsules; Chromatography, Liquid; Hypericum; Perylene; Spectrometry, Fluorescence; Tablets; United States | 2003 |
Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin.
Topics: Administration, Intravesical; Animals; Anthracenes; Carcinoma, Transitional Cell; Female; Perylene; Photochemotherapy; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 2003 |
Hypericin-mediated photodynamic therapy induces lipid peroxidation and necrosis in nasopharyngeal cancer.
Topics: Animals; Anthracenes; Antioxidants; Apoptosis; Cell Line, Tumor; Cytoplasm; Humans; Light; Lipid Peroxidation; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Nasopharyngeal Neoplasms; Necrosis; Neoplasm Transplantation; Oxygen; Perylene; Photochemotherapy; Reactive Oxygen Species; Superoxide Dismutase; Time Factors | 2003 |
Photodynamic therapy of transitional cell carcinoma multicellular tumor spheroids with hypericin.
Topics: Anthracenes; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Radiation; Humans; Light; Microscopy, Fluorescence; Oxygen; Perylene; Photochemotherapy; Photosensitizing Agents; Radiation-Sensitizing Agents; Time Factors | 2003 |
Potentiation of photodynamic therapy with hypericin by mitomycin C in the radiation-induced fibrosarcoma-1 mouse tumor model.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Synergism; Female; Fibrosarcoma; Mice; Mitomycin; Perylene | 2003 |
Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.
Topics: Anthracenes; Apoptosis; Blotting, Western; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Perylene; Photochemotherapy; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Transcription, Genetic; Transfection; Up-Regulation | 2003 |
Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin.
Topics: Anthracenes; Carcinoma, Transitional Cell; Diagnostic Imaging; Fluorescence; Humans; Microscopy, Confocal; Perylene; Sensitivity and Specificity; Spectrophotometry; Urinary Bladder Neoplasms | 2003 |
Photodynamic effect of hypericin and a water-soluble derivative on isolated crayfish neuron and surrounding glial cells.
Topics: Animals; Anthracenes; Astacoidea; Dose-Response Relationship, Drug; Neuroglia; Neurons; Perylene; Photochemotherapy; Photosensitizing Agents; Solubility; Water | 2003 |
[Influence of luyoutal on serum cytokines in patients with depression].
Topics: Adult; Anthracenes; Antidepressive Agents; Bipolar Disorder; Drugs, Chinese Herbal; Female; Humans; Interferon-gamma; Interleukin-1; Interleukin-6; Male; Middle Aged; Perylene; Phytotherapy; Tumor Necrosis Factor-alpha | 2003 |
Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex.
Topics: Animals; Anthracenes; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Cell Membrane; Fluoxetine; Frontal Lobe; Hypericum; Imipramine; Male; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Terpenes | 2004 |
Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Death; Cell Division; Cell Line, Tumor; Darkness; HSP90 Heat-Shock Proteins; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mitosis; Perylene; Ubiquitin | 2003 |
Flow injection analysis mass spectrometry, a tool to investigate the problems in the quantitative analysis of hypericin using reversed-phase high-performance liquid chromatography.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Flow Injection Analysis; Mass Spectrometry; Perylene; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Accumulation and photocytotoxicity of hypericin and analogs in two- and three-dimensional cultures of transitional cell carcinoma cells.
Topics: Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Cell Culture Techniques; Cell Death; Humans; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Structure-Activity Relationship | 2003 |
Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Cell Survival; Flow Cytometry; Humans; Hypericum; K562 Cells; Perylene; Phytotherapy; Plant Extracts | 2004 |
Detection of hypericins in the "red glands" of Hypericum elodes by ESI-MS/MS.
Topics: Anthracenes; Flowers; Hypericum; Microscopy, Electron, Scanning; Perylene; Spectrometry, Mass, Electrospray Ionization | 2004 |
Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cell-Free System; Dose-Response Relationship, Drug; Humans; Light; Male; Matrix Metalloproteinase 1; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Oxygen; Perylene; Photochemotherapy; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Up-Regulation | 2004 |
Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores.
Topics: Adaptation, Physiological; Animals; Anthracenes; Anti-Bacterial Agents; Biological Assay; Bridged Bicyclo Compounds; Coleoptera; Enzyme Inhibitors; Feeding Behavior; Hypericum; Larva; Moths; Perylene; Phloroglucinol; Plants, Edible; Terpenes | 2003 |
Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin.
Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Flow Cytometry; Genes, MDR; Herb-Drug Interactions; Humans; Hypericum; Mice; NIH 3T3 Cells; Perylene; Phloroglucinol; Terpenes | 2004 |
Determination of hypericin content in Hypericum triquetrifolium Turra (Hypericaceae) growing wild in Jordan.
Topics: Anthracenes; Calibration; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hypericum; Jordan; Perylene; Plant Extracts | 2004 |
Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells.
Topics: Animals; Anthracenes; Cell Differentiation; Cell Division; Down-Regulation; Glutathione Transferase; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Nasopharyngeal Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Tumor Cells, Cultured | 2004 |
Antimetastatic activity of the photodynamic agent hypericin in the dark.
Topics: Animals; Anthracenes; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Humans; Light; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Perylene; Signal Transduction; Survival Analysis; Tissue Distribution | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
[The influence of extraction method on the quality of the liquid extract of St John's wort].
Topics: Anthracenes; Antidepressive Agents; Drug Stability; Flavonoids; Humans; Hypericum; Perylene; Phytotherapy; Plant Extracts; Time Factors | 2004 |
Undeclared exposure to St. John's Wort in hospitalized patients.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Bridged Bicyclo Compounds; Drug Interactions; Hospitalization; Humans; Hypericum; Middle Aged; Perylene; Phloroglucinol; Self Medication; Substance Abuse Detection; Terpenes | 2004 |
Photodynamic-induced vascular damage of the chick chorioallantoic membrane model using perylenequinones.
Topics: Animals; Anthracenes; Blood Vessels; Chickens; Chorioallantoic Membrane; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Quinones | 2004 |
A novel antioxidant role for ligandin behavior of glutathione S-transferases: attenuation of the photodynamic effects of hypericin.
Topics: Acyltransferases; Amino Acid Sequence; Anthracenes; Antioxidants; Bacterial Proteins; Carrier Proteins; Fluorescence; Glutathione Transferase; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Iodine; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oxidation-Reduction; Oxygen; Peptides; Perylene; Photochemistry; Photochemotherapy; Protein Structure, Tertiary; Reactive Oxygen Species; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Spectrum Analysis | 2004 |
Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burst.
Topics: Anthracenes; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Biological Transport; Cell Differentiation; Cytochromes c; Fluoresceins; HL-60 Cells; Humans; Light; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; Perylene; Phorbol Esters; Photochemotherapy; Protein Kinase C; Reactive Oxygen Species; Respiratory Burst; Superoxides | 2004 |
[Effects of hypericin on traumatic proliferative vitreoretinopathy in rabbits].
Topics: Animals; Anthracenes; Eye Injuries; Injections, Intralesional; Perylene; Protein Kinase C; Rabbits; Vitreoretinopathy, Proliferative | 2002 |
[Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method].
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Flavonoids; Humans; Hypericum; Perylene; Quercetin; Rutin; Time Factors | 2004 |
Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry.
Topics: Aged; Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2004 |
[Determining the quantity of hypericin in medicinal materials and asepsis seedings of Hypericum perforatum by HPLC].
Topics: Anthracenes; China; Chromatography, High Pressure Liquid; Ecosystem; Hypericum; Perylene; Plants, Medicinal; Quality Control; Seasons | 2003 |
[Effect of factors on callus biomass and synthetic mass of hypericin in Hypericum perforatum].
Topics: Anthracenes; Culture Media; Hypericum; Mannose; Nitrogen; Perylene; Plants, Medicinal; Povidone; Tissue Culture Techniques | 2003 |
Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bridged Bicyclo Compounds; Cell Line, Tumor; Colonic Neoplasms; Digoxin; Humans; Hypericum; LLC-PK1 Cells; Perylene; Phloroglucinol; Plant Extracts; Rifampin; Swine; Terpenes; Transfection | 2005 |
Hypericin-an inhibitor of proteasome function.
Topics: Anthracenes; Antidepressive Agents; Electrophoretic Mobility Shift Assay; Glioma; Humans; Mammary Neoplasms, Animal; NF-kappa B; Perylene; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Tumor Cells, Cultured | 2005 |
In vivo accumulation of different hypericin ion pairs in the urothelium of the rat bladder.
Topics: Administration, Intravesical; Animals; Anthracenes; Drug Carriers; Female; Ions; Microscopy, Fluorescence; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium | 2005 |
Comparative chemical composition and variability of biological activity of methanolic extracts from Hypericum perforatum L.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Methanol; Microbial Sensitivity Tests; Perylene; Plant Extracts; Quercetin; Rutin; Solvents | 2005 |
Stability of different formulations and ion pairs of hypericin.
Topics: Anthracenes; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Stability; Humans; Ions; Perylene | 2005 |
Determination of hypericin in human plasma by high-performance liquid chromatography after intravesical administration in patients with transitional cell carcinoma of the bladder.
Topics: Administration, Intravesical; Anthracenes; Carcinoma, Transitional Cell; Chromatography, High Pressure Liquid; HeLa Cells; Humans; Male; Perylene; Urinary Bladder Neoplasms | 2005 |
Elucidation of the tumoritropic principle of hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Caco-2 Cells; Carbocyanines; Carbon Radioisotopes; Female; Humans; Lipoproteins; Mice; Microscopy, Fluorescence; Neoplasm Transplantation; Neoplasms, Experimental; Perylene; Photosensitizing Agents; Rats; Tissue Distribution | 2005 |
[Enhancement of hypericin production and cell growth of Hypericum perforatum L. suspension cultures by nitric oxide].
Topics: Anthracenes; Cells, Cultured; Hypericum; Nitric Oxide; Nitroprusside; Perylene; Phenylalanine Ammonia-Lyase; Plant Growth Regulators | 2005 |
Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation.
Topics: Anthracenes; Apoptosis; Carcinoma, Transitional Cell; Cell Line, Tumor; Fluorescence; Humans; Light; Oxygen; Perylene; Photochemotherapy; Spheroids, Cellular; Urinary Bladder Neoplasms | 2005 |
Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Ejaculation; Humans; Hypericum; Isometric Contraction; Male; Muscle, Smooth; Orgasm; Perylene; Phloroglucinol; Rats; Terpenes; Tissue Culture Techniques; Vas Deferens | 2005 |
Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy.
Topics: Anthracenes; Cells, Cultured; DNA Damage; Humans; Hypericum; Keratinocytes; Perylene; Phytotherapy; Ultraviolet Therapy | 2005 |
Is photodynamic diagnosis using hypericin better than white-light cystoscopy for detecting superficial bladder carcinoma?
Topics: Aged; Aged, 80 and over; Anthracenes; Cystoscopy; Early Diagnosis; Female; Humans; Male; Middle Aged; Perylene; Radiation-Sensitizing Agents; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2005 |
Hypericin in the dark inhibits key steps of angiogenesis in vitro.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Capillaries; Cell Line; Cell Movement; Cell Proliferation; Collagen; Darkness; Dose-Response Relationship, Drug; Drug Combinations; Endothelial Cells; Laminin; Matrix Metalloproteinase 2; Perylene; Proteoglycans; Radiation-Sensitizing Agents; Time Factors; Urokinase-Type Plasminogen Activator | 2005 |
Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment.
Topics: Animals; Anthracenes; Biological Transport; Chick Embryo; Chorioallantoic Membrane; Perylene; Photochemotherapy | 2005 |
Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer.
Topics: Anthracenes; Cell Line, Tumor; Humans; Interleukin-6; Nasopharyngeal Neoplasms; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; RNA, Messenger | 2006 |
Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells.
Topics: Anthracenes; Carcinoma, Transitional Cell; Cell Line, Tumor; Humans; Perylene; Radiation-Sensitizing Agents; Spheroids, Cellular; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urothelium | 2005 |
Identification and quantification of hypericin and pseudohypericin in different Hypericum perforatum L. in vitro cultures.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Culture Techniques; Hypericum; Perylene; Plant Growth Regulators | 2005 |
Raman spectroscopic study on structure of human immunodeficiency virus (HIV) and hypericin-induced photosensitive damage of HIV.
Topics: Anthracenes; HIV; HIV Seropositivity; HIV-1; HIV-2; Humans; Hydrogen Bonding; Lipid Bilayers; Perylene; Phenylalanine; Protein Structure, Secondary; Radiation-Sensitizing Agents; RNA, Viral; Spectrum Analysis, Raman; Tryptophan; Tyrosine; Viral Proteins | 2005 |
Competitive quenching: a possible novel approach in protecting RPE cells from damage during PDT.
Topics: Animals; Anthracenes; Cell Line; Cell Survival; Choroidal Neovascularization; Cytoprotection; Male; Oxidation-Reduction; Perylene; Photochemotherapy; Photosensitizing Agents; Pigment Epithelium of Eye; Porphyrins; Rabbits; Rats; Rats, Wistar; Retina; Tetrazolium Salts; Thiazoles; Verteporfin | 2005 |
Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model.
Topics: Animals; Anthracenes; Chick Embryo; Chorioallantoic Membrane; Drug Carriers; Light; Models, Biological; Molecular Structure; Neovascularization, Physiologic; Perylene; Photochemotherapy; Photosensitizing Agents; Pyrrolidinones | 2006 |
Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.
Topics: Adult; Aged; Anthracenes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Diazepam; Drug Interactions; Female; Flow Cytometry; GABA Modulators; Glioblastoma; Humans; Male; Middle Aged; Perylene; Photochemotherapy; Tumor Cells, Cultured | 2005 |
Anti-angiogenic activities of hypericin in vivo: potential for ophthalmologic applications.
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Anthracenes; Cornea; Corneal Neovascularization; Disease Models, Animal; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Genes, Tumor Suppressor; Humans; Iris; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Nuclear Proteins; Perylene; Phosphorylation; Rats; Rats, Wistar; Retinal Neovascularization; Vascular Endothelial Growth Factor A | 2005 |
Nitric oxide mediates the fungal elicitor-induced hypericin production of Hypericum perforatum cell suspension cultures through a jasmonic-acid-dependent signal pathway.
Topics: Anthracenes; Aspergillus niger; Cells, Cultured; Cyclopentanes; Fungal Proteins; Hypericum; Nitric Oxide; Oxylipins; Perylene; Plant Growth Regulators; Signal Transduction | 2005 |
Photoinduced antitumour effect of hypericin can be enhanced by fractionated dosing.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Administration Schedule; Fibrosarcoma; Hypericum; Injections, Intraperitoneal; Light; Male; Mice; Mice, Inbred Strains; Perylene; Photochemotherapy; Photosensitizing Agents; Phytotherapy | 2005 |
Hypericin-photodynamic therapy (PDT) using an alternative treatment regime suitable for multi-fraction PDT.
Topics: Animals; Anthracenes; Apoptosis; Calcium; Immunohistochemistry; Light; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Atomic Force; Nasopharyngeal Neoplasms; Necrosis; Oxygen; Perylene; Photochemotherapy; Photosensitizing Agents; Time Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Zinc | 2006 |
Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma; Humans; Male; Mice; Mice, Inbred BALB C; Nasopharyngeal Neoplasms; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; RNA, Messenger | 2005 |
p53 Status does not affect photodynamic cell killing induced by hypericin.
Topics: Anthracenes; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Humans; Osteosarcoma; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Tumor Suppressor Protein p53 | 2006 |
Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.
Topics: Anthracenes; Biological Transport; Cell Line; Cell Proliferation; Humans; Molecular Structure; Perylene; Photosensitizing Agents | 2005 |
Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy.
Topics: Anthracenes; Cell Line; Cell Movement; Drug Delivery Systems; Endothelial Cells; Enzyme Inhibitors; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 14; Neovascularization, Pathologic; Perylene; Photochemotherapy; Photosensitizing Agents; Protein Kinase C; Signal Transduction | 2005 |
Single-drop liquid-phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Osmolar Concentration; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro.
Topics: Animals; Animals, Newborn; Anthracenes; Astrocytes; Cell Line, Tumor; Cells, Cultured; Fluorescence; Glioblastoma; Humans; Microscopy, Fluorescence; Neurons; Perylene; Rats; Time Factors; Tumor Cells, Cultured | 2005 |
Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Celecoxib; Cyclooxygenase 2; Drug Therapy, Combination; Evans Blue; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Mice, Inbred BALB C; Middle Aged; Nasopharyngeal Neoplasms; Necrosis; Neovascularization, Pathologic; Perylene; Photochemotherapy; Pyrazoles; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2005 |
Content analysis and stability evaluation of selected commercial preparations of St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Environment; Hardness; Humidity; Hypericum; Indicators and Reagents; Perylene; Reference Standards; Reproducibility of Results; Solvents; Spectrophotometry, Ultraviolet; Tablets; Temperature | 2005 |
Can St John's wort (hypericin) ingestion enhance the erythemal response during high-dose ultraviolet A1 therapy?
Topics: Adult; Anthracenes; Antidepressive Agents; Dose-Response Relationship, Radiation; Erythema; Humans; Hypericum; Middle Aged; Perylene; Phytotherapy; Plant Extracts; Radiation Injuries; Radiotherapy Dosage; Severity of Illness Index; Ultraviolet Therapy | 2005 |
Anion of hypericin is crucial to understanding the photosensitive features of the pigment.
Topics: Anions; Anthracenes; Electrons; Molecular Structure; Perylene; Phenol; Photochemotherapy; Photosensitizing Agents; Pigments, Biological; Quinones; Singlet Oxygen | 2006 |
Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors.
Topics: Animals; Anthracenes; Biflavonoids; Bridged Bicyclo Compounds; Carrier Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cells, Cultured; Fluoxetine; Fluvoxamine; Food; Hypericum; Ligands; Macrophages; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Osteoclasts; Perylene; Phloroglucinol; Plant Extracts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Recombinant Proteins; Serotonin; Stress, Physiological; Terpenes; Time Factors | 2005 |
Photophysical properties of Hypericum perforatum L. extracts--novel photosensitizers for PDT.
Topics: Anthracenes; Hydrogen-Ion Concentration; Hypericum; Methanol; Perylene; Photochemistry; Photochemotherapy; Photosensitizing Agents; Plant Extracts; Spectrometry, Fluorescence | 2006 |
[Effects of hypericin associated with light irradiation on human laryngeal squamous cell carcinoma strain Hep-2].
Topics: Anthracenes; Apoptosis; Carcinoma, Squamous Cell; Cell Proliferation; Hep G2 Cells; Humans; Laryngeal Neoplasms; Light; Perylene | 2005 |
First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent.
Topics: Animals; Anthracenes; Drug Evaluation, Preclinical; Heart; Liver; Metabolic Clearance Rate; Myocardial Infarction; Myocardium; Necrosis; Perylene; Pilot Projects; Rabbits; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Tissue Distribution | 2006 |
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy.
Topics: Animals; Anthracenes; Apoptosis; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Calcium; Calcium-Transporting ATPases; Cell Line; Endoplasmic Reticulum; Fibroblasts; Gene Deletion; Humans; Mice; Perylene; Photochemotherapy; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2006 |
Genetic and biochemical analysis of Hypericum perforatum L. plants regenerated after cryopreservation.
Topics: Anthracenes; Chromosomes, Plant; Cryopreservation; DNA, Plant; Hypericum; Karyotyping; Perylene; Plant Shoots; Regeneration; Seedlings; Tissue Culture Techniques | 2006 |
The impact of aggregation on the biodistribution of hypericin.
Topics: Animals; Anthracenes; Cell Line, Tumor; Female; Injections, Intravenous; Liver; Lung; Metabolic Clearance Rate; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Muscles; Neoplasms, Experimental; Perylene; Radiation-Sensitizing Agents; Skin; Solutions; Spleen; Suspensions; Time Factors; Tissue Distribution | 2006 |
Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Fluorocarbons; Humans; Light; Microscopy, Fluorescence; Oxygen; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Spheroids, Cellular; Urinary Bladder Neoplasms | 2006 |
[Effects of hypericin associated with radiotherapy on human laryngeal squamous cell carcinoma strain Hep-2].
Topics: Anthracenes; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Laryngeal Neoplasms; Perylene | 2005 |
Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin.
Topics: Anthracenes; Apoptosis; Bromodeoxyuridine; Cell Cycle; DNA Replication; Dose-Response Relationship, Drug; HT29 Cells; Humans; Hydrolysis; Indoles; Lipoxygenase Inhibitors; Perylene; Photochemotherapy; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species | 2006 |
Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin.
Topics: Anthracenes; Apoptosis; Cell Line; Glutathione Transferase; Humans; Kidney; Light; Perylene; Photochemotherapy; Treatment Outcome | 2006 |
Maristentorin, a novel pigment from the positively phototactic marine ciliate Maristentor dinoferus, is structurally related to hypericin and stentorin.
Topics: Animals; Anthracenes; Chromatography, Gel; Ciliophora; Marine Biology; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Polycyclic Compounds | 2006 |
Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort.
Topics: Anthracenes; Chemical Fractionation; Chromatography, Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene | 2006 |
Induction of hypericins in Hypericum perforatum in response to chromium.
Topics: Analysis of Variance; Anthracenes; Chromium; Gene Expression Regulation; Hypericum; Perylene; Plants, Medicinal; Seedlings | 2006 |
Characterization of apoptosis induced by photodynamic treatment with hypericin in A431 human epidermoid carcinoma cells.
Topics: Adenosine Triphosphate; Anthracenes; Apoptosis; Carcinoma, Squamous Cell; Caspases; Cell Line, Tumor; Humans; Membrane Potentials; Mitochondria; Perylene; Photochemotherapy; Photosensitizing Agents | 2006 |
Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Sonication; Terpenes | 2006 |
The action of photosensitizers and serum in a bactericidal process. II. The effects of dyes: hypericin, eosin Y and saphranine O.
Topics: Anthracenes; Bacillus subtilis; Bacteria; Blood Bactericidal Activity; Coloring Agents; Eosine Yellowish-(YS); Escherichia coli K12; Humans; In Vitro Techniques; Perylene; Phenazines; Photobiology; Photosensitizing Agents; Shigella flexneri | 2005 |
Preservation of hypericin and related polycyclic quinone pigments in fossil crinoids.
Topics: Animals; Anthracenes; Chromatography, High Pressure Liquid; Echinodermata; Fossils; Perylene; Quinones; Spectrometry, Mass, Electrospray Ionization | 2006 |
Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Dacarbazine; Disease Models, Animal; Down-Regulation; Drug Synergism; Glioblastoma; Growth Inhibitors; Humans; Male; Mice; Mice, Nude; Perylene; Tamoxifen; Temozolomide; Transplantation, Heterologous; Treatment Outcome | 2006 |
Mitochondria are a primary target of hypericin phototoxicity: synergy of intracellular calcium mobilisation in cell killing.
Topics: Aconitate Hydratase; Anthracenes; Calcium; Cell Line, Tumor; Cell Respiration; Cell Survival; Cytoplasm; Dose-Response Relationship, Radiation; Glutathione; Humans; Hydrogen Peroxide; Light; Male; Mitochondria; Perylene; Radiation-Sensitizing Agents; Reactive Oxygen Species; Superoxide Dismutase | 2006 |
Interaction of glutathione S-transferase with hypericin: A photophysical study.
Topics: Anthracenes; Chemical Phenomena; Chemistry, Physical; Dimethyl Sulfoxide; Glutathione Transferase; Kinetics; Light; Oxygen; Perylene; Photochemistry; Photolysis; Protons; Serum Albumin; Spectrophotometry, Ultraviolet | 2005 |
Reduction in hypericin-induced phototoxicity by Hypericum perforatum extracts and pure compounds.
Topics: Anthracenes; Cell Line; Cell Proliferation; Humans; Hypericum; Oxidation-Reduction; Perylene; Photochemistry; Plant Extracts | 2006 |
Hypericin and pulsed laser therapy of squamous cell cancer in vitro.
Topics: Anthracenes; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Head and Neck Neoplasms; Humans; Perylene; Photochemotherapy; Tumor Cells, Cultured | 2006 |
Plant-environment interactions: Accumulation of hypericin in dark glands of Hypericum perforatum.
Topics: Anthracenes; Ecosystem; Flowers; Hypericum; Light; Molecular Structure; Perylene; Photosynthesis; Plant Leaves; Plant Shoots; Plant Stems | 2006 |
Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer.
Topics: Animals; Anthracenes; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Delivery Systems; Female; Humans; Lactic Acid; Nanoparticles; Ovarian Neoplasms; Perylene; Photochemotherapy; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Inbred F344; Technology, Pharmaceutical | 2006 |
Expression of the hyp-1 gene in early stages of development of Hypericum perforatum L.
Topics: Anthracenes; DNA, Complementary; Gene Expression; Genes, Plant; Hypericum; Peptide Elongation Factor 1; Perylene; Plant Leaves; Plant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Plant | 2007 |
[Sunburn -- or yet not?].
Topics: Aged; Aged, 80 and over; Anthracenes; Dermatitis, Contact; Diagnosis, Differential; Humans; Hypericum; Male; Perylene; Sunburn | 2006 |
[Evaluation of preparing process of extract of hypericum perforatum using HPLC fingerprint analysis].
Topics: Anthracenes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Hypericum; Perylene; Plant Components, Aerial; Plants, Medicinal; Quality Control; Quercetin; Rutin; Technology, Pharmaceutical | 2006 |
Variation in the content of hypericins in four generations of seed progeny of Hypericum perforatum somaclones.
Topics: Anthracenes; Base Sequence; Chromosomes, Plant; DNA Primers; DNA, Plant; Genetic Variation; Hypericum; Minisatellite Repeats; Perylene; Polymerase Chain Reaction; Seeds | 2007 |
Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone formulations.
Topics: Anthracenes; Kinetics; Perylene; Photochemistry; Pyrrolidinones; Solubility; Spectrometry, Fluorescence; Thermodynamics | 2006 |
Differential up-regulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin.
Topics: Anthracenes; Flow Cytometry; Humans; In Vitro Techniques; Metallothionein; Nasopharyngeal Neoplasms; Necrosis; Perylene; Photochemotherapy; Photosensitizing Agents; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Up-Regulation | 2006 |
Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Disease Models, Animal; Fibrosarcoma; Humans; Hypericum; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C3H; Perylene; Photochemotherapy; Photosensitizing Agents; Phytotherapy; Plant Extracts; Radiation Dosage | 2007 |
Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Binding, Competitive; Blotting, Western; Cattle; Cell Cycle; Cell Line, Tumor; Cell Survival; Cisplatin; Crystallography, X-Ray; Culture Media; DNA, Neoplasm; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Fetal Blood; Gold Compounds; Humans; Metalloporphyrins; Molecular Structure; Perylene; Spectrophotometry, Ultraviolet; Tumor Suppressor Protein p53 | 2007 |
Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Survival; Chick Embryo; Chorioallantoic Membrane; Cystoscopy; Fluoroscopy; Humans; Hydrogen-Ion Concentration; Neoplasm Transplantation; Perylene; Photosensitizing Agents; Pyrrolidinones; Spectrometry, Fluorescence; Transplantation, Heterologous; Urinary Bladder Neoplasms | 2007 |
Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Hypericum; Indomethacin; Perylene; Plant Extracts; Rats | 2007 |
In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems.
Topics: Amides; Animals; Anthracenes; Cattle; Cell Line, Tumor; Cell Membrane; Diffusion; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Models, Chemical; Perylene; Photosensitizing Agents; Protein Binding; Tumor Cells, Cultured | 2007 |
Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Enzyme Induction; Enzyme Inhibitors; Heme Oxygenase-1; Humans; MAP Kinase Signaling System; Neoplasms; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Perylene; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Photochemotherapy; Radiation-Sensitizing Agents; RNA, Small Interfering | 2007 |
In vitro photodynamic therapy of childhood rhabdomyosarcoma.
Topics: Animals; Anthracenes; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cell Survival; Child; DNA Fragmentation; Fibroblasts; Flow Cytometry; Humans; Ki-67 Antigen; Mice; Perylene; Photochemotherapy; Rhabdomyosarcoma; Tetrazolium Salts; Thiazoles | 2007 |
Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Glioblastoma; Glioma; Humans; Light; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Time Factors | 2007 |
Hypericin activates L-type Ca2+ channels in cardiac myocytes.
Topics: Action Potentials; Animals; Anthracenes; Calcium Channels, L-Type; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; Heart; Molecular Structure; Myocytes, Cardiac; Nitric Oxide Synthase Type II; Oxadiazoles; Perylene; Phosphoprotein Phosphatases; Ranidae; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2007 |
The production of hypericins in two selected Hypericum perforatum shoot cultures is related to differences in black gland structure.
Topics: Anthracenes; Cells, Cultured; Hypericum; Microscopy, Electron, Scanning; Perylene; Plant Leaves; Plant Shoots | 2007 |
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Camptothecin; Cell Line, Tumor; Cell Proliferation; Glucuronides; Hypericum; Irinotecan; Male; Microsomes, Liver; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes | 2007 |
[The development of secondary cells in the callus of Hypericum perforatum L. and hypericins accumulation].
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Microscopy, Electron, Transmission; Molecular Structure; Perylene; Tissue Culture Techniques | 2007 |
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Circular Dichroism; Depression; Drug Evaluation, Preclinical; Endothelial Cells; Humans; Hypericum; Lipoproteins, LDL; Malondialdehyde; Mass Spectrometry; Molecular Structure; Nonprescription Drugs; Oxidation-Reduction; Peroxidase; Perylene; Phloroglucinol; Phytotherapy; Protein Binding; Structure-Activity Relationship; Terpenes; Thiobarbituric Acid Reactive Substances; Thromboplastin; Tyrosine; Umbilical Veins | 2007 |
Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Down-Regulation; Fibroblasts; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 4, Human; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Nasopharyngeal Neoplasms; NF-kappa B; Perylene; Photochemotherapy; Transcription Factor AP-1; Transcriptional Activation | 2007 |
Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
Topics: Administration, Topical; Animals; Anthracenes; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Croton Oil; Dose-Response Relationship, Drug; Edema; Flavonoids; Flowers; Hypericum; Inhibitory Concentration 50; Male; Mice; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Response Elements; Tablets; Terpenes; Transcription Factors; Transfection; Tumor Cells, Cultured | 2007 |
Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma.
Topics: Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Colonic Neoplasms; Cytosol; Dihematoporphyrin Ether; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Superoxide Dismutase | 2007 |
Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens.
Topics: Acetates; Agrobacterium tumefaciens; Anthracenes; Bridged Bicyclo Compounds; Cyclopentanes; Hypericum; Oxylipins; Perylene; Phloroglucinol; Polyethylene Glycols; Seeds; Sucrose; Terpenes | 2007 |
Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.
Topics: Adenocarcinoma; Anthracenes; Caspase 3; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Radiation; Gene Expression; HeLa Cells; HT29 Cells; Humans; Light; Necrosis; Perylene; Photochemotherapy; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2007 |
Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice.
Topics: Acecainide; Animals; Anthracenes; Biological Availability; Female; Herb-Drug Interactions; Hypericum; Mice; Perylene; Procainamide | 2007 |
[Morphological identification of 20 medicinal species in Hypericum].
Topics: Anthracenes; Flowers; Fruit; Hypericum; Oils, Volatile; Perylene; Plant Leaves; Plant Stems; Plants, Medicinal; Species Specificity | 2007 |
Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells.
Topics: Absorption; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mitoxantrone; Models, Biological; Perylene; Photochemotherapy; Tissue Distribution; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2007 |
Fluorescence detection of bladder cancer using urine cytology.
Topics: Anthracenes; Automation; Humans; Image Processing, Computer-Assisted; Microscopy, Confocal; Microscopy, Fluorescence; Models, Statistical; Perylene; Photosensitizing Agents; Reproducibility of Results; Sensitivity and Specificity; Urinalysis; Urinary Bladder Neoplasms | 2007 |
Effect of hypericin-mediated photodynamic therapy on the expression of vascular endothelial growth factor in human nasopharyngeal carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Celecoxib; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Nasopharyngeal Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Pyrazoles; RNA, Messenger; Sulfonamides; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2007 |
Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.
Topics: Analysis of Variance; Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Female; Glycosaminoglycans; Microscopy, Fluorescence; Perylene; Photosensitizing Agents; Rats; Rats, Inbred F344; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium | 2007 |
Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy.
Topics: Anthracenes; Antineoplastic Agents; Biological Availability; Carcinoma; Diagnostic Imaging; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Imaging, Three-Dimensional; Indoles; Microscopy, Confocal; Perylene; Photochemotherapy; Pyrrolidinones; Teratogens; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2007 |
Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete.
Topics: Anthracenes; Antidepressive Agents; Flowers; Greece; Hypericum; Perylene; Plant Leaves; Plants, Medicinal; Seasons; Species Specificity | 2007 |
Herbal medicine in the treatment of mental disorders.
Topics: Anthracenes; Brain; Fatty Acids, Omega-3; Ginkgo biloba; Humans; Kava; Mental Disorders; Perylene; Phytotherapy; Plant Extracts; Plant Preparations; Treatment Outcome; Valerian | 2007 |
Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.
Topics: Anthracenes; Apoptosis; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Perylene; Photochemotherapy; Photosensitizing Agents; Protein Kinase C; Radiation-Sensitizing Agents; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Urinary Bladder Neoplasms | 2008 |
Influence of application and formulation factors on the penetration of hypericin in normal mouse skin and UV induced skin tumors.
Topics: Administration, Topical; Animals; Anthracenes; Female; Fluorescence; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Perylene; Photochemotherapy; Skin; Skin Absorption; Skin Neoplasms; Ultraviolet Rays | 2007 |
Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by downregulating angiogenic proteins.
Topics: Angiogenic Proteins; Animals; Anthracenes; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Down-Regulation; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Neoplasms, Experimental; Perylene; Photochemotherapy; Photosensitizing Agents; Time Factors; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2007 |
Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Anthracenes; Dermatitis, Phototoxic; Female; Male; Mice; Mice, Inbred BALB C; Perylene; Photosensitizing Agents; Radiation-Sensitizing Agents; Skin; Time Factors | 2008 |
Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.
Topics: Analysis of Variance; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Ethanol; Female; Fibrosarcoma; Injections, Intralesional; Liver Neoplasms; Mice; Microscopy, Fluorescence; Necrosis; Neoplasm Transplantation; Perylene | 2008 |
Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Iodine Radioisotopes; Male; Myocardial Infarction; Necrosis; Perylene; Rabbits; Radiopharmaceuticals; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2008 |
Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.
Topics: Animals; Anthracenes; Base Sequence; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Lysophosphatidylcholines; Lysophospholipids; Mice; Molecular Sequence Data; Multienzyme Complexes; Organ Specificity; Perylene; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Substrate Specificity | 2008 |
1H NMR determination of hypericin and pseudohypericin in complex natural mixtures by the use of strongly deshielded OH groups.
Topics: Anthracenes; Chromatography, Liquid; Hydrogen Bonding; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Plant Extracts; Spectrophotometry, Ultraviolet | 2008 |
An endophytic fungus from Hypericum perforatum that produces hypericin.
Topics: Anthracenes; Aspergillus niger; Candida albicans; DNA, Fungal; Gram-Negative Bacteria; Gram-Positive Bacteria; Hypericum; Microbial Sensitivity Tests; Molecular Structure; Perylene | 2008 |
Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Cell Line, Tumor; Humans; Hypericum; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; Male; NF-kappa B; Nitric Oxide Synthase Type II; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; STAT1 Transcription Factor; Terpenes; Tumor Necrosis Factor-alpha | 2008 |
Hypericin-mediated photodynamic therapy of pituitary tumors: preclinical study in a GH4C1 rat tumor model.
Topics: Animals; Anthracenes; Apoptosis; In Situ Nick-End Labeling; Perylene; Photochemotherapy; Pituitary Neoplasms; Radiation-Sensitizing Agents; Rats; Rats, Wistar | 2008 |
Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Hypericum; Ischemia; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Oxygen; Perylene; Phosphorylation; Retina; Retinal Diseases; Retinal Neovascularization | 2008 |
Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Intracellular Space; Keratinocytes; Melanocytes; Melanoma; Necrosis; Perylene; Photochemotherapy; Photosensitizing Agents; Skin | 2008 |
Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin.
Topics: Anthracenes; Antineoplastic Agents; Cadherins; Carcinoma, Transitional Cell; Cell Line, Tumor; Clone Cells; Humans; Perylene; Photosensitizing Agents; Spheroids, Cellular; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2008 |
Exploration of the mechanism underlying the tumor necrosis avidity of hypericin.
Topics: Animals; Anthracenes; Carbocyanines; Female; Fibrosarcoma; Lipoproteins; Mice; Mice, Inbred C3H; Necrosis; Perylene; Sarcoma, Experimental; Xanthones | 2008 |
Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model.
Topics: Animals; Anthracenes; Biomarkers; Catheter Ablation; Female; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Necrosis; Perylene | 2008 |
Hypericin uptake: a prognostic marker for survival in high-grade glioma.
Topics: Adult; Aged; Anthracenes; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease-Free Survival; Drug Resistance, Neoplasm; Drug Therapy; Female; Fluorescence; Glioblastoma; Glioma; Humans; Light; Lipoproteins, LDL; Male; Microscopy, Fluorescence; Middle Aged; Models, Statistical; Perylene; Photochemotherapy; Predictive Value of Tests; Prognosis; Radiation-Sensitizing Agents; Radiotherapy; Survival Rate | 2008 |
Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss. subsp. apollinis (Boiss. & Heldr.) Robson & Strid methanol extract.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Chlorogenic Acid; Chondrus; Chromatography, High Pressure Liquid; Edema; Flavonoids; Hindlimb; Hypericum; Male; Methanol; Perylene; Phenols; Plant Components, Aerial; Plant Extracts; Polyphenols; Quercetin; Rats; Rats, Wistar; Rutin | 2008 |
Crystallization and preliminary crystallographic studies of Hyp-1, a St John's wort protein implicated in the biosynthesis of hypericin.
Topics: Amino Acid Sequence; Anthracenes; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Hypericum; Molecular Sequence Data; Perylene; Plant Proteins; Sequence Homology, Amino Acid | 2008 |
How to make hypericin water-soluble.
Topics: Anthracenes; Antidepressive Agents; Carcinoma, Transitional Cell; Chemical Phenomena; Chemistry, Physical; Drug Delivery Systems; Flow Cytometry; Humans; Hydrogen Bonding; K562 Cells; Leukocytes; Perylene; Pharmaceutic Aids; Photochemistry; Povidone; Solubility; Spectrometry, Fluorescence; Water | 2008 |
Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy.
Topics: Angiogenic Proteins; Animals; Anthracenes; Blotting, Western; Cell Line, Tumor; Endoscopy; Fluorescence; Gene Expression Profiling; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Neovascularization, Pathologic; Perylene; Photochemotherapy; Photosensitizing Agents; Polymerase Chain Reaction; Protein Array Analysis; Time Factors; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2008 |
Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Roots; Plants, Genetically Modified; Terpenes; Transformation, Genetic | 2008 |
Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins.
Topics: Anthracenes; Base Sequence; Chromatography, Liquid; DNA Primers; Escherichia coli; Hypericum; In Situ Hybridization; Molecular Sequence Data; Perylene; Phylogeny; Polyketide Synthases; Recombinant Proteins; RNA Probes; Spectrometry, Mass, Electrospray Ionization | 2008 |
Signal interaction between nitric oxide and hydrogen peroxide in heat shock-induced hypericin production of Hypericum perforatum suspension cells.
Topics: Anthracenes; Antidepressive Agents; Cells, Cultured; Enzyme Inhibitors; Heat-Shock Response; Humans; Hydrogen Peroxide; Hypericum; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Perylene; Signal Transduction | 2008 |
Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin.
Topics: Anthracenes; Apoptosis; Cell Cycle; Colonic Neoplasms; Drug Synergism; HT29 Cells; Humans; Indoles; Lipoxygenase Inhibitors; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Signal Transduction | 2008 |
In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study.
Topics: alpha-Crystallins; Amyloid beta-Peptides; Anthracenes; Circular Dichroism; Fluorescent Dyes; Humans; Kinetics; Peptide Fragments; Perylene; Spectrometry, Fluorescence | 2008 |
Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress.
Topics: Acridine Orange; Animals; Anthracenes; Calcium Channels; Calcium Signaling; Cell Line; Cell Membrane; Dithiothreitol; Ferrous Compounds; Ganglia, Spinal; Humans; Hydrogen Peroxide; Intracellular Space; Ion Channel Gating; Nerve Tissue Proteins; Neurons; Oxidative Stress; Perylene; Photosensitizing Agents; Rats; Rats, Wistar; Transient Receptor Potential Channels; TRPA1 Cation Channel; Ultraviolet Rays | 2009 |
Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors.
Topics: Anthracenes; Antimycin A; Binding Sites; Cell Line, Tumor; Cytochromes c; Electron Transport Complex III; Humans; Light; Methacrylates; Mitochondria; Mitochondrial Proton-Translocating ATPases; Models, Molecular; Perylene; Spectrophotometry, Ultraviolet; Submitochondrial Particles; Thiazoles; Ubiquinone | 2008 |
In vitro photodynamic therapy in pediatric epithelial liver tumors promoted by hypericin.
Topics: Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Flow Cytometry; Hepatoblastoma; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Liver Neoplasms; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents | 2008 |
Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Delivery Systems; Endoscopy; Female; Fluorescence; Injections, Intravenous; Lactic Acid; Nanoparticles; Neoplasm Metastasis; Ovarian Neoplasms; Perylene; Photosensitizing Agents; Polyesters; Polymers; Rats; Rats, Inbred F344; Tissue Distribution | 2009 |
Effects of different concentrations of benzylaminopurine on shoot regeneration and hypericin content in Hypericum triquetrifolium Turra.
Topics: Anthracenes; Benzyl Compounds; Germination; Hypericum; Perylene; Plant Shoots; Purines; Regeneration | 2009 |
Variation of hypericins in Hypericum triquetrifolium Turra growing in different locations of Turkey during plant growth.
Topics: Anthracenes; Hypericum; Perylene; Plants, Medicinal; Turkey | 2008 |
Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin.
Topics: Animals; Anthracenes; Apoptosis; Bridged Bicyclo Compounds; DNA Fragmentation; Drugs, Chinese Herbal; Hypericum; Inhibition, Psychological; Male; Mice; Perylene; Phloroglucinol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Reflex, Acoustic; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Terpenes | 2009 |
Photodynamic effect of hypericin in primary cultures of human umbilical endothelial cells and glioma cell lines.
Topics: Anthracenes; Cell Line, Tumor; Cell Movement; DNA Fragmentation; Endothelial Cells; Gelatinases; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neovascularization, Pathologic; Perylene; Photochemotherapy; Photosensitizing Agents | 2009 |
Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.
Topics: Anthracenes; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Female; Haplotypes; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Preparations; Pregnane X Receptor; Receptors, Steroid; Terpenes; Young Adult | 2009 |
Screening of nanoparticulate delivery systems for the photodetection of cancer in a simple and cost-effective model.
Topics: Animals; Anthracenes; Cell Line, Tumor; Chick Embryo; Chickens; Chorioallantoic Membrane; Early Detection of Cancer; Female; Fluorescence; Nanoparticles; Ovarian Neoplasms; Perylene; Rats | 2009 |
[Studies on the chemical constituents of flowers of Prunus mume].
Topics: Anthracenes; Benzoic Acid; Flavonols; Flowers; Molecular Structure; Perylene; Plants, Medicinal; Prunus; Quercetin | 2008 |
Photosensitized production of singlet oxygen: spatially-resolved optical studies in single cells.
Topics: Anthracenes; HeLa Cells; Humans; Luminescent Measurements; Microscopy, Fluorescence; Neurons; Perylene; Photons; Photosensitizing Agents; Singlet Oxygen | 2009 |
Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC.
Topics: Acetates; Anthracenes; Chromatography, Gel; Dextrans; Enzyme Inhibitors; Hexanes; Hypericum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methanol; Perylene; Plant Extracts; Solvents; Water | 2009 |
Lipid-mediated preferential localization of hypericin in lipid membranes.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Anthracenes; Calcium Channels; Cholesterol; Dietary Supplements; Dimyristoylphosphatidylcholine; Lipids; Liposomes; Models, Molecular; Perylene; Phosphatidylcholines; Spectrometry, Fluorescence; Surface Properties | 2009 |
Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light.
Topics: Aminolevulinic Acid; Anthracenes; Apoptosis; Cell Line, Tumor; Drug Synergism; Endometrial Neoplasms; Female; Humans; Light; Perylene; Photosensitizing Agents; Protoporphyrins | 2009 |
In vitro study of the photocytotoxicity of bathochromically-shifted hypericin derivatives.
Topics: Absorption; Animals; Anthracenes; Biological Transport; Cell Line, Tumor; Cell Proliferation; Humans; Intracellular Space; Light; Perylene; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; Spectrometry, Fluorescence | 2009 |
Genotoxicity and antigenotoxicity evaluation of non-photoactivated hypericin.
Topics: Animals; Anthracenes; Antimutagenic Agents; Cell Line, Tumor; Chlamydomonas reinhardtii; Chromosome Aberrations; Cricetinae; DNA Damage; Humans; Mutagenicity Tests; Perylene; Saccharomyces cerevisiae | 2010 |
Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer.
Topics: Anthracenes; Cell Line, Tumor; Drug Delivery Systems; Female; Fluorescence; Humans; Nanoparticles; Ovarian Neoplasms; Perylene; Photosensitizing Agents; Phototherapy | 2009 |
Nanovesicles released by Dictyostelium cells: a potential carrier for drug delivery.
Topics: Animals; Anthracenes; Antineoplastic Agents; Benzimidazoles; Cell Line; Cell Survival; Dictyostelium; Drug Carriers; Endosomes; Golgi Apparatus; HeLa Cells; Humans; Nanotechnology; Perylene; Proteomics | 2009 |
Comment on "Hypericin uptake: a prognostic marker for survival in high-grade glioma".
Topics: Anthracenes; Brain Neoplasms; Glioma; Humans; Perylene | 2009 |
Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy.
Topics: Anthracenes; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Humans; Melanins; Melanoma; Monophenol Monooxygenase; Perylene; Photochemotherapy; Radiation Tolerance; Radiation-Sensitizing Agents; Skin Neoplasms; Ultraviolet Rays | 2009 |
Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Perylene; Polysaccharides; Stereoisomerism; Teicoplanin | 2010 |
Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum.
Topics: Anthracenes; Chromatography, Liquid; Discriminant Analysis; Emodin; Hypericum; Multivariate Analysis; Perylene; Principal Component Analysis; Tandem Mass Spectrometry | 2009 |
Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Flavonoids; Flowers; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Reference Standards; Species Specificity; Terpenes | 2010 |
Chemical constituents and antidepressant activity of the new species Hypericum enshiense occurring in China.
Topics: Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; China; Depression; Disease Models, Animal; Flavonoids; Hindlimb Suspension; Hypericum; Male; Mice; Mice, Inbred Strains; Motor Activity; Perylene; Phytotherapy; Plant Components, Aerial; Plant Extracts; Swimming | 2010 |
Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin.
Topics: Anthracenes; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Oligonucleotide Array Sequence Analysis; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; Time Factors | 2009 |
Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Kaempferols; Perylene; Phloroglucinol; Quercetin; Terpenes; Turkey | 2009 |
Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis.
Topics: Anthracenes; Antineoplastic Agents; Base Sequence; Drug Screening Assays, Antitumor; Emodin; Humans; Hypericum; Light; Metabolomics; Molecular Structure; Perylene; Sordariales | 2009 |
Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Carcinoma, Squamous Cell; Diagnostic Imaging; Endoscopy; Female; Fluorescence; Humans; Hyperplasia; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Perylene | 2009 |
Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin.
Topics: Anthracenes; Antidepressive Agents; Crystallization; Dimerization; Emodin; Hypericum; Models, Molecular; Molecular Structure; Perylene; Plant Proteins; Protein Conformation | 2010 |
The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells.
Topics: Anthracenes; Caspase 3; Cell Cycle; Cell Survival; Colonic Neoplasms; Colony-Forming Units Assay; Enzyme Activation; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mitochondrial Membranes; Perylene; Phosphatidylserines; Photochemotherapy; Time Factors; Tumor Suppressor Protein p53 | 2009 |
The association between self-reported cataracts and St. John's Wort.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anthracenes; Cataract; Depression; Female; Humans; Hypericum; Lens, Crystalline; Male; Middle Aged; Perylene; Sex Factors; Surveys and Questionnaires; White People | 2009 |
Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells.
Topics: Anthracenes; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 7; Cell Division; Cell Line, Tumor; Down-Regulation; Female; G2 Phase; Genistein; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Perylene; Phosphorylation; Photochemotherapy; Photosensitizing Agents; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2 | 2010 |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Compounding; Hypericum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Perylene; Phorbol Esters; Phytotherapy; Protein Kinase C; Quercetin; Somatostatin; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric; Time Factors | 2010 |
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Caspase 3; Caspase 9; Colonic Neoplasms; Enzyme Inhibitors; HT29 Cells; Humans; Light; Membrane Potential, Mitochondrial; Mixed Function Oxygenases; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Perylene; Photochemotherapy; Photosensitizing Agents; Proadifen; Reactive Oxygen Species | 2009 |
St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity.
Topics: Analgesics; Animals; Anthracenes; Hypericum; Male; Pain; Perylene; Phytotherapy; Plant Extracts; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley | 2010 |
Interaction dynamics of hypericin with low-density lipoproteins and U87-MG cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Membrane; Fluorescence; Glioma; Humans; Hydrophobic and Hydrophilic Interactions; Lipoproteins, LDL; Perylene; Photosensitizing Agents | 2010 |
Hypericin, the active component of St. John's wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway.
Topics: Animals; Anthracenes; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Hypericum; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Perylene; Rats; Rats, Sprague-Dawley; Synaptosomes | 2010 |
Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus.
Topics: Anthracenes; Anti-Bacterial Agents; Humans; Mesoporphyrins; Microbial Sensitivity Tests; Perylene; Photochemotherapy; Photosensitizing Agents; Staphylococcal Infections; Staphylococcus aureus | 2010 |
Hypericin prolongs action potential duration in hippocampal neurons by acting on K+ channels.
Topics: Action Potentials; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Hippocampus; Ion Channel Gating; Neurons; Patch-Clamp Techniques; Perylene; Potassium Channels; Rats; Rats, Sprague-Dawley | 2010 |
Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells.
Topics: Anthracenes; Antibodies, Monoclonal; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Delivery Systems; Humans; Liposomes; Liver Neoplasms; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Serum Albumin | 2010 |
Effects of hypericin on the structure and aggregation properties of β-amyloid peptides.
Topics: Amyloid beta-Peptides; Anthracenes; Peptide Fragments; Perylene; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared | 2010 |
Topical treatment of disseminated superficial actinic porokeratosis with hypericin-photodynamic therapy: a case report.
Topics: Administration, Topical; Aged; Anthracenes; Antineoplastic Agents; Female; Humans; Middle Aged; Perylene; Photochemotherapy; Porokeratosis | 2010 |
Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder.
Topics: Aminolevulinic Acid; Animals; Anthracenes; Antineoplastic Agents; Female; Fluorescence; Perylene; Photochemotherapy; Povidone; Protoporphyrins; Rats; Rats, Inbred F344; Solubility; Tissue Distribution; Urinary Bladder Neoplasms | 2011 |
Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells.
Topics: Anthracenes; Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Repair; DNA Replication; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Glutathione; Humans; Light; Mitochondria; Nasopharyngeal Neoplasms; Oligonucleotide Array Sequence Analysis; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Reactive Oxygen Species | 2010 |
Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport.
Topics: Anthracenes; Biological Transport; Calcium; Cell Line; Cell Survival; Female; Humans; Hypericum; Perylene; Placenta; Plant Extracts; Pregnancy; Trophoblasts | 2010 |
Comparative in vitro study on the characteristics of different photosensitizers employed in PDT.
Topics: Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dihematoporphyrin Ether; Humans; Indoles; Mesoporphyrins; Organometallic Compounds; Perylene; Photochemotherapy; Photosensitizing Agents | 2010 |
Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance.
Topics: Anthracenes; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Quercetin; Rutin; Terpenes | 2010 |
Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage.
Topics: Adenine; Animals; Anthracenes; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Endoplasmic Reticulum; Gene Expression; Glutathione Peroxidase; Humans; Mice; Microtubule-Associated Proteins; Molecular Chaperones; Oncogene Protein v-akt; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Thapsigargin; TOR Serine-Threonine Kinases | 2011 |
Interaction between hypericin and hemoglobin.
Topics: Anthracenes; Hemoglobins; Hemolysis; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Light; Male; Oxidation-Reduction; Perylene; Spectrometry, Fluorescence | 2010 |
Inhibition characteristics of hypericin on rat small intestine glutathione-S-transferases.
Topics: Animals; Anthracenes; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Intestine, Small; Kinetics; Perylene; Rats; Rats, Sprague-Dawley | 2010 |
PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Arachidonic Acid; Cell Line, Tumor; Colonic Neoplasms; Docosahexaenoic Acids; Fatty Acids, Unsaturated; HT29 Cells; Humans; Membrane Fluidity; Oxidative Stress; Perylene; Photochemotherapy | 2010 |
Pharmacological studies on Hypericum perforatum fractions and constituents.
Topics: Animals; Anthracenes; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypericum; In Vitro Techniques; Male; Perylene; Phloroglucinol; Phosphodiesterase Inhibitors; Plant Extracts; Quercetin; Rabbits; Terpenes; Verapamil | 2011 |
Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.
Topics: Amino Acid Substitution; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Biocatalysis; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Estradiol; Flavonoids; Flavonols; Genotype; Humans; Hydroxylation; Hypericum; Perylene; Phenols; Plant Extracts; Polyphenols; Quercetin; Recombinant Proteins; Resveratrol; Stereoisomerism; Stilbenes; Substrate Specificity | 2011 |
Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer.
Topics: Aged; Aged, 80 and over; alpha Catenin; Anthracenes; beta Catenin; Cadherins; Cell Adhesion Molecules; Cell Membrane; Cytoplasm; Desmoplakins; Female; gamma Catenin; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Microscopy, Confocal; Middle Aged; Neoplasm Grading; Neoplasm Staging; Perylene; Radiation-Sensitizing Agents; Reverse Transcriptase Polymerase Chain Reaction; Urinary Bladder Neoplasms | 2012 |
Photodynamic therapy using topically applied hypericin: comparative effect with methyl-aminolevulinic acid on UV induced skin tumours.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Female; Keratosis, Actinic; Mice; Mice, Hairless; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms; Ultraviolet Rays | 2011 |
Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids.
Topics: Anthracenes; Carcinoma; Cells, Cultured; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Porphyrins; Serum Albumin; Spectrophotometry, Ultraviolet; Spheroids, Cellular; Urinary Bladder Neoplasms; Urothelium | 2011 |
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.
Topics: Amino Acid Sequence; Anthracenes; Inhibitory Concentration 50; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Perylene; Sequence Homology, Amino Acid; Thioredoxin-Disulfide Reductase | 2011 |
The possible use of hypericin to overcome drug resistance in cancer treatment.
Topics: Anthracenes; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Drug Resistance, Neoplasm; Humans; Neoplasms; Perylene | 2011 |
Photoactivated hypericin induces downregulation of HER2 gene expression.
Topics: Anthracenes; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Female; Genes, erbB-2; Humans; Perylene; Photochemotherapy; Reactive Oxygen Species; Receptor, ErbB-2; Singlet Oxygen | 2011 |
Hypericin incorporation and localization in fixed HeLa cells for various conditions of fixation and incubation.
Topics: Anthracenes; Culture Media; Female; HeLa Cells; Humans; Microscopy, Fluorescence; Perylene; Photosensitizing Agents; Uterine Cervical Neoplasms | 2011 |
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.
Topics: Adenocarcinoma; Anthracenes; Cell Line; Colon; Colonic Neoplasms; Epithelial Cells; Fetus; Humans; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species | 2011 |
Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemical Fractionation; Chromatography, High Pressure Liquid; Countercurrent Distribution; Flavonols; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2011 |
On the diffusion of hypericin in dimethylsulfoxide/water mixtures-the effect of aggregation.
Topics: Absorption; Anthracenes; Diffusion; Dimethyl Sulfoxide; Models, Molecular; Molecular Conformation; Perylene; Photosensitizing Agents; Spectrometry, Fluorescence; Water | 2011 |
Selective enrichment of hypericin in malignant glioma: pioneering in vivo results.
Topics: Animals; Anthracenes; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Glioma; Male; Neoplasm Transplantation; Perylene; Rats; Rats, Wistar | 2011 |
Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin.
Topics: Ablation Techniques; Animals; Anthracenes; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Humans; Mice; Mice, Nude; Nanoparticles; Organometallic Compounds; Peptides; Perylene; Phosphatidylserines; Positron-Emission Tomography; Sulfides; Surface Plasmon Resonance; Treatment Outcome | 2011 |
Lipophilic rather than hydrophilic photosensitizers show strong adherence to standard cell culture microplates under cell-free conditions.
Topics: Anthracenes; Cell Adhesion; Cell Culture Techniques; Cell-Free System; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Microscopy, Fluorescence; Neoplasms, Glandular and Epithelial; Organometallic Compounds; Perylene; Photochemotherapy; Photosensitizing Agents; Plastics; Polyvinyls; Pyrrolidines; Tumor Cells, Cultured | 2011 |
Enhancing hypericin production of Hypericum perforatum cell suspension culture by ozone exposure.
Topics: Anthracenes; Cells, Cultured; Hypericum; Ozone; Perylene | 2011 |
Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Monophenol Monooxygenase; Perylene; Phenylthiourea; Photochemotherapy; Photosensitizing Agents; Pigmentation; Reactive Oxygen Species | 2011 |
Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi.
Topics: Anthracenes; Glomeromycota; Hypericum; Mycorrhizae; Perylene; Plants, Medicinal | 2012 |
A dual-targeting anticancer approach: soil and seed principle.
Topics: Animals; Anthracenes; Iodine Radioisotopes; Perylene; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rhabdomyosarcoma; Treatment Outcome | 2011 |
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
Topics: Anthracenes; Antidepressive Agents; Biological Products; Dermatitis, Phototoxic; DNA Damage; Enzyme Inhibitors; Hypericum; Light; Lipid Peroxidation; Perylene; Phloroglucinol; Plant Extracts; Reactive Oxygen Species; Terpenes | 2011 |
Flavonoid glycosides and naphthodianthrones in the sawfly Tenthredo zonula and its host-plants, Hypericum perforatum and H. hirsutum.
Topics: Animals; Anthracenes; Flavonoids; Glycosides; Host-Parasite Interactions; Hymenoptera; Hypericum; Larva; Perylene | 2011 |
Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Mice; Mice, Inbred C3H; Necrosis; Neoplasms; Neovascularization, Pathologic; Organophosphorus Compounds; Perylene; Telomere-Binding Proteins; Xanthones | 2011 |
Biphasic dose-response of antioxidants in hypericin-induced photohemolysis.
Topics: Algorithms; Anthracenes; Antioxidants; Ascorbic Acid; Calcium Channels; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Humans; Male; Peroxidases; Perylene; Photosensitizing Agents; Protein Kinase C; Quercetin; Reactive Oxygen Species; Superoxide Dismutase; Time Factors | 2011 |
Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy.
Topics: Anthracenes; Antineoplastic Agents; Blotting, Western; Cathepsin B; Cell Hypoxia; Cell Line; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Hydrogen-Ion Concentration; Hypoxia-Inducible Factor 1, alpha Subunit; Metabolism; Neoplasms; Perylene; Promoter Regions, Genetic; Protein Binding; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; Ubiquitination; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Long-term monitoring of live cell proliferation in presence of PVP-Hypericin: a new strategy using ms pulses of LED and the fluorescent dye CFSE.
Topics: Anthracenes; Cell Line; Cell Proliferation; Cell Survival; Epithelial Cells; Fluorescent Dyes; Humans; Lighting; Microscopy, Fluorescence; Perylene; Staining and Labeling | 2012 |
Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential.
Topics: Animals; Anthracenes; Autoradiography; Female; Fibrosarcoma; Fluorodeoxyglucose F18; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Necrosis; Neoplasms, Radiation-Induced; Perylene; Prognosis; Radionuclide Imaging; Random Allocation | 2012 |
Antiangiogenesis agents avastin and erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blotting, Western; Cell Movement; Cetuximab; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Neovascularization, Physiologic; Perylene; Photochemotherapy; Photosensitizing Agents; Random Allocation; Signal Transduction; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A | 2011 |
[Study on the enzyme extraction process of hypericin by pectinase].
Topics: Analysis of Variance; Anthracenes; Chromatography, High Pressure Liquid; Dextranase; Hydrogen-Ion Concentration; Hypericum; Perylene; Plant Components, Aerial; Plants, Medicinal; Polygalacturonase; Reproducibility of Results; Technology, Pharmaceutical; Temperature; Time Factors | 2011 |
Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma.
Topics: Animals; Anthracenes; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Mice; Mice, Inbred BALB C; Perylene; Photochemotherapy; Photosensitizing Agents; Remission Induction; Treatment Outcome | 2011 |
Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy.
Topics: Animals; Anthracenes; Antineoplastic Agents; Avidin; Biotin; Biotinylation; Cell Line, Tumor; Contrast Media; Ethanol; Female; Iodine Radioisotopes; Mice; Mice, Inbred C3H; Necrosis; Neoplasms; Perylene; Tissue Distribution | 2012 |
Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin.
Topics: Animals; Anthracenes; Anthracyclines; Apoptosis; Cell Line; Dendritic Cells; Hematoporphyrin Photoradiation; Humans; Inflammation; Mice; Neoplasms; Perylene; Protein Disulfide-Isomerases; Reactive Oxygen Species | 2012 |
Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A.
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 7; Cell Proliferation; Enzyme Inhibitors; HT29 Cells; Humans; Lamin Type B; Perylene; Poly(ADP-ribose) Polymerases; Polyenes; Polyunsaturated Alkamides; Radiation-Sensitizing Agents; ras Proteins | 2011 |
Hypericin for visualization of high grade gliomas: first clinical experience.
Topics: Aged; Anthracenes; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Injections, Intravenous; Male; Middle Aged; Perylene; Photosensitizing Agents; Predictive Value of Tests; Sensitivity and Specificity | 2012 |
Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria.
Topics: Anthracenes; Anti-Bacterial Agents; Hypericum; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Mycobacterium; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2012 |
Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light.
Topics: Anthracenes; Food Microbiology; Listeria monocytogenes; Perylene; Photoperiod; Salmonella typhimurium; Ultraviolet Rays | 2012 |
On the mechanism of Candida spp. photoinactivation by hypericin.
Topics: Anthracenes; Benzoquinones; Candida; Candida albicans; Hydrogen Peroxide; Kinetics; Light; Microscopy, Fluorescence; Perylene; Radiation-Sensitizing Agents; Singlet Oxygen | 2012 |
Laser light activation of a second-generation photosensitiser and its use as a potential photomodulatory agent in skin rejuvenation.
Topics: Anthracenes; Cell Survival; Dose-Response Relationship, Drug; Fibroblasts; Humans; Lasers; Lasers, Solid-State; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Rejuvenation; Skin; Ultraviolet Rays | 2013 |
Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Humans; Melanins; Melanoma; Perylene; Photochemotherapy; Pigmentation; Radiation-Sensitizing Agents | 2012 |
Content of hypericins from plants and in vitro shoots of Hypericum undulatum Schousb. ex Willd.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Molecular Structure; Perylene; Plant Shoots | 2013 |
Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species.
Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Plant Leaves; Plant Stems; Terpenes; Turkey | 2012 |
Inhibitors of translation targeting eukaryotic translation initiation factor 4A.
Topics: Animals; Anthracenes; Benzofurans; Epoxy Compounds; Eukaryotic Initiation Factor-4A; Humans; Macrolides; Perylene; Protein Kinase Inhibitors; Sterols; Thiazoles | 2012 |
Pattern of sensitivity of progressive cutaneous squamous cell carcinoma cells to UVB and oxidative stress-induced cell death.
Topics: Anthracenes; Apoptosis; Carcinoma, Squamous Cell; Humans; Hydrogen Peroxide; Oxidative Stress; Perylene; Photosensitizing Agents; Tumor Cells, Cultured; Ultraviolet Rays | 2013 |
Cell death response of U87 glioma cells on hypericin photoactivation is mediated by dynamics of hypericin subcellular distribution and its aggregation in cellular organelles.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Endocytosis; Fluorescence Resonance Energy Transfer; Glioma; Humans; Lipoproteins, LDL; Membrane Potential, Mitochondrial; Microscopy, Confocal; Organelles; Perylene; Photosensitizing Agents | 2012 |
Evaluation of the in vitro inhibitory impact of hypericin on placental glutathione S-transferase pi.
Topics: Anthracenes; Dinitrochlorobenzene; Electrophoresis, Polyacrylamide Gel; Female; Glutathione; Glutathione S-Transferase pi; Humans; Hypericum; Kinetics; Perylene; Placenta; Pregnancy; Substrate Specificity | 2012 |
[Rapid cloning and functional characterization of hypericin synthase gene].
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Chemistry Techniques, Synthetic; Emodin; Escherichia coli; Gene Expression Regulation, Plant; Genes, Plant; Genetic Vectors; Hypericum; Peptide Synthases; Perylene; Plant Proteins; Plants, Medicinal; Recombinant Proteins; Transformation, Genetic | 2012 |
Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer cells.
Topics: Anthracenes; Cell Line, Tumor; Dextrans; Drug Carriers; Humans; Hydrophobic and Hydrophilic Interactions; Lipoproteins, LDL; Neoplasms; Perylene; Radiation-Sensitizing Agents | 2012 |
Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species.
Topics: Animals; Anthracenes; Apoptosis; Autophagy; Cell Line, Tumor; Endoplasmic Reticulum; Mice; Mitochondria; Mitophagy; Organelles; Oxidation-Reduction; Oxidative Stress; Perylene; Photosensitizing Agents; Reactive Oxygen Species; Time Factors | 2012 |
Identifying the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) as a potential target for hypericin--a theoretical study.
Topics: Anthracenes; Antineoplastic Agents; Enzyme Inhibitors; Humans; Hydroquinones; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Perylene; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Structure-Activity Relationship; Thapsigargin | 2012 |
Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures.
Topics: Anthracenes; Bacteria; Chromatography, High Pressure Liquid; Culture Media; Hypericum; Perylene; Plant Shoots; Rhizosphere; Seedlings; Tissue Culture Techniques | 2012 |
A basic study on hypericin-PDT in vitro.
Topics: Anthracenes; Apoptosis; Dose-Response Relationship, Radiation; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Radiation Dosage; U937 Cells | 2012 |
Hypericin-PDT-induced rapid necrotic death in human squamous cell carcinoma cultures after multiple treatment.
Topics: Anthracenes; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Hypericum; Necrosis; Perylene; Photochemotherapy; Reactive Oxygen Species; Skin Neoplasms | 2012 |
The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Enzyme Activation; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intracellular Space; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Neoplasm Invasiveness; Perylene; Phloroglucinol; Photochemotherapy; Reactive Oxygen Species; Terpenes | 2012 |
A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Compounding; Female; Iodine Isotopes; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Molecular Structure; Molecular Targeted Therapy; Organ Specificity; Perylene; Time Factors; Toxicity Tests | 2012 |
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder.
Topics: Animals; Anthracenes; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Hypericum; Hypoxia; Ischemia; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Perylene; Phloroglucinol; Plant Extracts; Potassium Chloride; Rats; Rats, Sprague-Dawley; Terpenes; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder, Overactive | 2012 |
Preparation of a polyclonal antibody against hypericin synthase and localization of the enzyme in red-pigmented Hypericum perforatum L. plantlets.
Topics: Animals; Anthracenes; Antibodies; Antidepressive Agents; Hypericum; Peptide Synthases; Perylene; Plant Extracts; Plant Stems; Rabbits | 2012 |
Effects of hypericin and a chlorin based photosensitizer alone or in combination in squamous cell carcinoma cells in the dark.
Topics: Anthracenes; Cell Line, Tumor; Darkness; DNA Damage; Dose-Response Relationship, Drug; Drug Combinations; Humans; Liposomes; Mesoporphyrins; Neoplasms, Squamous Cell; Perylene; Photochemotherapy; Photosensitizing Agents; RNA; trans-Golgi Network | 2012 |
In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells.
Topics: Aminolevulinic Acid; Anthracenes; Cell Line, Tumor; Cerebellar Neoplasms; Humans; Medulloblastoma; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2012 |
PAL inhibitor evokes different responses in two Hypericum species.
Topics: Amino Acids; Anthracenes; Chlorogenic Acid; Hypericum; Indans; Organophosphonates; Perylene; Phenols; Phenylalanine Ammonia-Lyase | 2013 |
Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets.
Topics: Animals; Anthracenes; Cold Temperature; CREB-Binding Protein; Hot Temperature; Hyperalgesia; Hypericum; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Pain Measurement; Perylene; Plant Extracts; Protein Kinase C; Random Allocation; STAT1 Transcription Factor | 2013 |
Spatial orientation and electric-field-driven transport of hypericin inside of bilayer lipid membranes.
Topics: Anthracenes; Biological Transport; Cell Membrane; Electrophoresis; Lipid Bilayers; Models, Molecular; Molecular Conformation; Perylene; Spectrometry, Fluorescence | 2013 |
Modifying excitation light dose of novel photosensitizer PVP-Hypericin for photodynamic diagnosis and therapy.
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Diagnostic Imaging; Dose-Response Relationship, Radiation; Fluoresceins; Humans; Light; Perylene; Photobleaching; Photochemotherapy; Photosensitizing Agents; Povidone; Succinimides; Time Factors | 2013 |
Structural and photophysical properties of peptide micro/nanotubes functionalized with hypericin.
Topics: Anthracenes; Microscopy, Electron, Scanning; Nanotubes; Peptides; Perylene; X-Ray Diffraction | 2013 |
Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts.
Topics: Administration, Intravenous; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Fibrosarcoma; Histocytochemistry; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Male; Mice; Mice, SCID; Perylene; Radiography; Radionuclide Imaging; Stilbenes; Survival Analysis; Transplantation, Heterologous; Treatment Outcome | 2013 |
Hypericin-mediated photooxidative damage of α-crystallin in human lens epithelial cells.
Topics: alpha-Crystallins; Animals; Anthracenes; Cataract; Cattle; Cell Line; Epithelial Cells; Humans; Kynurenine; Oxidative Stress; Perylene; Photosensitizing Agents; Ultraviolet Rays | 2013 |
Bcl-2 proapoptotic proteins distribution in U-87 MG glioma cells before and after hypericin photodynamic action.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Glioma; Humans; Light; Perylene; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Subcellular Fractions; Tissue Distribution; Treatment Outcome | 2013 |
Solubilization of poorly soluble photosensitizer hypericin by polymeric micelles and polyethylene glycol.
Topics: Anthracenes; Drug Carriers; Drug Compounding; Drug Stability; Materials Testing; Micelles; Perylene; Photosensitizing Agents; Polyethylene Glycols; Solubility | 2013 |
In vitro analysis of photosensitizer accumulation for assessment of applicability of fluorescence diagnosis of squamous cell carcinoma of epidermolysis bullosa patients.
Topics: Anthracenes; Carcinoma, Squamous Cell; Cell Line, Tumor; Epidermolysis Bullosa; False Positive Reactions; Fibroblasts; Fluorescent Dyes; Humans; Inflammation; Keratinocytes; Microscopy, Fluorescence; Perylene; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2013 |
Photosensitizer adhered to cell culture microplates induces phototoxicity in carcinoma cells.
Topics: Anthracenes; Carcinoma; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Membrane; Culture Media; Dermatitis, Phototoxic; Drug Delivery Systems; Humans; Indoles; Mesoporphyrins; Organometallic Compounds; Perylene; Photochemotherapy; Photosensitizing Agents; Plastics | 2013 |
Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer.
Topics: Anthracenes; beta-Cyclodextrins; Cellulose; Cyclodextrins; Magnetic Resonance Spectroscopy; Perylene; Solubility; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Water | 2013 |
Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis.
Topics: Animals; Anthracenes; Area Under Curve; Half-Life; Iodine Isotopes; Isotope Labeling; Male; Necrosis; Perylene; Radiopharmaceuticals; Rats; Rats, Wistar; Tissue Distribution | 2013 |
Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells.
Topics: ADAM Proteins; ADAMTS Proteins; ADAMTS9 Protein; Anthracenes; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Coloring Agents; Female; Gene Expression Regulation, Neoplastic; Humans; Hypericum; Perylene; Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Tetrazolium Salts | 2013 |
Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction.
Topics: Animals; Anthracenes; Autoradiography; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Gamma Cameras; Half-Life; Heart; Iodine Radioisotopes; Male; Myocardial Infarction; Myocardium; Necrosis; Perylene; Rabbits; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Technetium Tc 99m Sestamibi; Tissue Distribution; Tomography, X-Ray Computed | 2013 |
Photodynamic effect of hypericin on the microorganisms and primary human fibroblasts.
Topics: Anthracenes; Bacterial Physiological Phenomena; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Fibroblasts; Humans; Lighting; Microbial Viability; Perylene; Photochemotherapy; Photosensitizing Agents | 2013 |
ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death.
Topics: Adenosine Triphosphate; Anthracenes; Autophagy; Autophagy-Related Protein 5; Calreticulin; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Dendritic Cells; Gene Knockdown Techniques; Glutathione Peroxidase; Histidine; Humans; Interferon-gamma; Interleukin-6; Microtubule-Associated Proteins; Models, Biological; Neoplasms; Oxidation-Reduction; Perylene; Phenotype; Photochemotherapy; Reactive Oxygen Species | 2013 |
Hypericin-photodynamic therapy leads to interleukin-6 secretion by HepG2 cells and their apoptosis via recruitment of BH3 interacting-domain death agonist and caspases.
Topics: Anthracenes; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspases; Cell Shape; Cell Survival; DNA Fragmentation; Gene Expression; Hep G2 Cells; Humans; Inflammation Mediators; Interleukin-6; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Up-Regulation | 2013 |
Hypericin encapsulated in solid lipid nanoparticles: phototoxicity and photodynamic efficiency.
Topics: Animals; Anthracenes; Benzofurans; Cell Line, Tumor; Cell Survival; Humans; Light; Lipids; Mice; Nanoparticles; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Singlet Oxygen; Uric Acid | 2013 |
Antibiotic-free nanotherapeutics: hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing.
Topics: Animals; Anthracenes; Biofilms; Chemistry, Pharmaceutical; Disease Models, Animal; Female; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Methicillin-Resistant Staphylococcus aureus; Nanomedicine; Nanoparticles; Particle Size; Perylene; Photochemotherapy; Photosensitizing Agents; Polyesters; Polyethylene Glycols; Rats; Rats, Wistar; Reactive Oxygen Species; Technology, Pharmaceutical; Time Factors; Wound Healing; Wound Infection | 2013 |
Photodynamic fungicidal efficacy of hypericin and dimethyl methylene blue against azole-resistant Candida albicans strains.
Topics: Anthracenes; Antifungal Agents; Azoles; Candida albicans; Candidiasis; Combined Modality Therapy; Drug Resistance, Fungal; Humans; Light; Methylene Blue; Microbial Sensitivity Tests; Perylene; Photochemotherapy; Photosensitizing Agents | 2014 |
Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim.
Topics: Animals; Anthracenes; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Membrane Proteins; Mice; Perylene; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Up-Regulation | 2013 |
Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation.
Topics: Animals; Anthracenes; Antineoplastic Agents; Chemistry, Pharmaceutical; Dimethyl Sulfoxide; Iodine Radioisotopes; Liver; Male; Necrosis; Neoplasms; Perylene; Polyethylene Glycols; Radiopharmaceuticals; Rats; Spleen; Tissue Distribution; Water | 2014 |
In vivo molecular imaging of apoptosis and necrosis in atherosclerotic plaques using microSPECT-CT and microPET-CT imaging.
Topics: Animals; Annexin A5; Anthracenes; Apoptosis; Humans; Mice; Molecular Imaging; Multimodal Imaging; Necrosis; Perylene; Plaque, Atherosclerotic; Positron-Emission Tomography; Technetium; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2014 |
Hypericin-loaded lipid nanocapsules for photodynamic cancer therapy in vitro.
Topics: Anthracenes; Cell Line; Cell Survival; Drug Carriers; HeLa Cells; Humans; Hypericum; Light; Lipids; Microscopy, Video; Nanocapsules; Neoplasms; Particle Size; Perylene; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; Spectrophotometry, Ultraviolet | 2013 |
Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Humans; Light; Micelles; Mitochondria; Nanoparticles; Perylene; Phosphatidylethanolamines; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols | 2013 |
Unique anti-glioblastoma activities of hypericin are at the crossroad of biochemical and epigenetic events and culminate in tumor cell differentiation.
Topics: Anthracenes; Cell Cycle; Cell Differentiation; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Glioblastoma; Humans; Perylene | 2013 |
Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations.
Topics: Animals; Anthracenes; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Carriers; Fibrosarcoma; Iodine Radioisotopes; Liver; Male; Mice; Mice, SCID; Necrosis; Neoplasms, Experimental; Perylene; Rats; Rats, Wistar; Tissue Distribution | 2014 |
St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes.
Topics: Animals; Anthracenes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Flowers; Hyperalgesia; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Seeds; Sesquiterpenes; Tanacetum parthenium; Terpenes | 2014 |
Improved clearance of radioiodinated hypericin as a targeted anticancer agent by using a duodenal drainage catheter in rats.
Topics: Animals; Anthracenes; Antineoplastic Agents; Body Fluids; Brachytherapy; Catheters, Indwelling; Chemoradiotherapy; Chromatography, High Pressure Liquid; Duodenum; Iodine Radioisotopes; Mass Spectrometry; Perylene; Rats; Rats, Sprague-Dawley | 2013 |
Effect of glutathione on peroxyoxalate chemiluminescence of hypericin as the fluorophore.
Topics: Anthracenes; Fluorescent Dyes; Glutathione; Kinetics; Luminescence; Luminescent Measurements; Models, Chemical; Oxalates; Perylene; Sensitivity and Specificity | 2014 |
p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling.
Topics: Animals; Anthracenes; Autophagy; Cell Line; Fibroblasts; Gene Expression Regulation; Gene Knockout Techniques; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Light; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Perylene; Protein Aggregates; Protein Kinase Inhibitors; Proteins; Proteolysis; Radiation-Sensitizing Agents; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; Ubiquitin | 2014 |
Conjunction of glutathione level, NAD(P)H/FAD redox status and hypericin content as a potential factor affecting colon cancer cell resistance to photodynamic therapy with hypericin.
Topics: 3-Hydroxysteroid Dehydrogenases; Anthracenes; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Glutathione; Humans; Oxidation-Reduction; Perylene; Photochemotherapy; Photosensitizing Agents | 2013 |
Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model.
Topics: Animals; Anthracenes; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Endoscopy; Glioma; Metabolic Clearance Rate; Mice; Perylene; Photosensitizing Agents; Reproducibility of Results; Sensitivity and Specificity; Skin Neoplasms; Spectrometry, Fluorescence; Tissue Distribution | 2013 |
Optimizing the antitumor selectivity of PVP-Hypericin re A549 cancer cells and HLF normal cells through pulsed blue light.
Topics: Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Color; Dose-Response Relationship, Radiation; Drug Carriers; Humans; Lung Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Povidone; Sensitivity and Specificity; Treatment Outcome | 2013 |
Electroporation enhances antimicrobial photodynamic therapy mediated by the hydrophobic photosensitizer, hypericin.
Topics: Anthracenes; Anti-Bacterial Agents; Apoptosis; Cell Survival; Disinfection; Electroporation; Escherichia coli; Hydrophobic and Hydrophilic Interactions; Perylene; Photochemotherapy; Photosensitizing Agents; Staphylococcus aureus; Treatment Outcome | 2013 |
Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis.
Topics: Animals; Anthracenes; Disease Models, Animal; Iodine Radioisotopes; Liver; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Necrosis; Perylene; Rats, Sprague-Dawley; Sodium Cholate; Solubility; Solvents; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2014 |
Biodistribution and radiation dosimetry of radioiodinated hypericin as a cancer therapeutic.
Topics: Animals; Anthracenes; Female; Humans; Iodine Radioisotopes; Male; Neoplasms; Perylene; Radiation Dosage; Radiometry; Radiopharmaceuticals; Rats; Tissue Distribution | 2014 |
Photodynamic effect of hypericin after topical application in the ex ovo quail chorioallantoic membrane model.
Topics: Administration, Topical; Animals; Anthracenes; Blood Vessels; Chorioallantoic Membrane; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Lasers, Semiconductor; Perylene; Photochemotherapy; Polyethylene Glycols; Quail; Spectrometry, Fluorescence | 2014 |
Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction.
Topics: Animals; Anthracenes; Autoradiography; Disease Models, Animal; Gamma Cameras; Heart; Iodine Radioisotopes; Male; Microscopy, Fluorescence; Molecular Structure; Myocardial Infarction; Myocardium; Necrosis; Perylene; Rabbits; Radionuclide Imaging; Radiopharmaceuticals; Sodium Cholate; Solubility; Solutions; Tissue Distribution | 2015 |
Transport and accumulation of PVP-Hypericin in cancer and normal cells characterized by image correlation spectroscopy techniques.
Topics: Anthracenes; Cell Line, Tumor; Humans; Lung Neoplasms; Perylene; Photosensitizing Agents; Povidone; Spectrum Analysis | 2014 |
The interrelation between a pro-inflammatory milieu and fluorescence diagnosis or photodynamic therapy of human skin cell lines.
Topics: Anthracenes; Cell Line; Cell Survival; Cytokines; Dermatitis; Dose-Response Relationship, Drug; Humans; Keratinocytes; Microscopy, Fluorescence; Perylene; Photochemotherapy; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome | 2014 |
The role of anti-apoptotic protein kinase Cα in response to hypericin photodynamic therapy in U-87 MG cells.
Topics: Anthracenes; Apoptosis Regulatory Proteins; Cell Line, Tumor; Glioma; Humans; Perylene; Phosphorylation; Photochemotherapy; Photosensitizing Agents; Protein Kinase C-alpha; Proto-Oncogene Proteins c-bcl-2; Treatment Outcome | 2014 |
Proof-of-principle for simple microshelter-assisted buffer exchange in laser tweezers: interaction of hypericin with single cells.
Topics: Anthracenes; Buffers; Lasers; Optical Tweezers; Perylene; Spectrometry, Fluorescence; Yeasts | 2014 |
Interaction between different extracts of Hypericum perforatum L. from Serbia and pentobarbital, diazepam and paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Anti-Anxiety Agents; Capsules; Diazepam; Female; Herb-Drug Interactions; Hypericum; Male; Mice; Motor Activity; Pentobarbital; Perylene; Plant Extracts; Plants, Medicinal; Serbia; Solvents; Tablets | 2014 |
Photosensitizing effects of hypericin on head neck squamous cell carcinoma in vitro.
Topics: Anthracenes; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Head and Neck Neoplasms; Humans; In Situ Nick-End Labeling; Perylene; Photochemotherapy; Photosensitizing Agents; Squamous Cell Carcinoma of Head and Neck | 2015 |
Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: an experimental study in rats.
Topics: Administration, Topical; Animals; Anthracenes; Burns; Epidermis; Immunohistochemistry; Male; Perylene; Phenytoin; Rats; Rats, Wistar; Treatment Outcome; Wound Healing | 2014 |
PKC-mediated potentiation of morphine analgesia by St. John's Wort in rodents and humans.
Topics: Administration, Oral; Analgesia; Analgesics, Opioid; Animals; Anthracenes; Drug Synergism; Enzyme Inhibitors; Hot Temperature; Humans; Hypericum; Male; Mice; Morphine; Nociception; Pain Measurement; Periaqueductal Gray; Perylene; Phosphorylation; Plant Extracts; Protein Kinase C | 2014 |
[Chemical constituents of ethyl acetate fraction from Hypericum hengshanense].
Topics: Acetates; Anthracenes; Hypericum; Kaempferols; Magnetic Resonance Spectroscopy; Perylene; Plant Components, Aerial; Plants, Medicinal; Quercetin; Rutin | 2013 |
The role of water and structure on the generation of reactive oxygen species in peptide/hypericin complexes.
Topics: Anthracenes; Benzofurans; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Dynamics Simulation; Oxidation-Reduction; Peptides; Perylene; Reactive Oxygen Species; Water; X-Ray Diffraction | 2014 |
Amethystin, the coloring principle of Stentor amethystinus.
Topics: Anthracenes; Ciliophora; Coloring Agents; Germany; Lakes; Molecular Structure; Perylene; Polycyclic Compounds | 2014 |
Hypericum perforatum: Influences of the habitat on chemical composition, photo-induced cytotoxicity, and antiradical activity.
Topics: Altitude; Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line, Tumor; Cell Survival; Ecosystem; Free Radical Scavengers; Humans; Hypericum; Italy; Mice; Nitric Oxide; Perylene; Phenols; Photosensitizing Agents; Plant Components, Aerial; Plant Extracts; Rutin | 2014 |
Molecularly imprinted polymer for specific extraction of hypericin from Hypericum perforatum L. herbal extract.
Topics: Acetone; Acrylamide; Acrylates; Adsorption; Anthracenes; Binding Sites; Chromatography, High Pressure Liquid; Herbal Medicine; Hydrogen Bonding; Hypericum; Liquid-Liquid Extraction; Molecular Imprinting; Perylene; Plant Extracts; Polymers; Propylene Glycols; Solid Phase Extraction | 2014 |
Hypericin suppresses osteoclast formation and wear particle-induced osteolysis via modulating ERK signalling pathway.
Topics: Animals; Anthracenes; Bone Density Conservation Agents; Cell Line, Transformed; Cell Survival; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Osteoclasts; Osteolysis; Perylene; Prosthesis Failure; Random Allocation; RANK Ligand; Recombinant Proteins; Skull | 2014 |
Development of a multifunctional luciferase reporters system for assessing endoplasmic reticulum-targeting photosensitive compounds.
Topics: Anthracenes; Apoptosis; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Genes, Reporter; Heat-Shock Proteins; High-Throughput Screening Assays; Humans; Luciferases; MCF-7 Cells; Mesoporphyrins; Methylene Blue; Oxidative Stress; Perylene; Photochemotherapy; Photosensitizing Agents; Promoter Regions, Genetic; Reactive Oxygen Species; Transcription Factor CHOP; Transfection | 2014 |
Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells.
Topics: Anthracenes; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Death; Cell Line, Tumor; Cisplatin; Drug Interactions; Humans; Hypericum; Mitoxantrone; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Perylene; RNA, Messenger | 2014 |
Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis.
Topics: Animals; Anthracenes; Catheter Ablation; Dogs; Liver; Male; Necrosis; Perylene; Radiopharmaceuticals; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2015 |
St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death.
Topics: Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Size; Drug Screening Assays, Antitumor; Endoplasmic Reticulum; Female; Humans; Hypericum; Melanoma; Middle Aged; Perylene; Photochemotherapy; Photosensitizing Agents; Pigmentation; Skin Neoplasms; Transcriptional Activation | 2014 |
In vitro fungicidal photodynamic effect of hypericin on Trichophyton spp.
Topics: Anthracenes; Antifungal Agents; Colony Count, Microbial; Humans; Light; Microbial Viability; Perylene; Photosensitizing Agents; Time Factors; Trichophyton | 2014 |
Effects of UV-B radiation on total phenolic, flavonoid and hypericin contents in Hypericum retusum Aucher grown under in vitro conditions.
Topics: Anthracenes; Benzyl Compounds; Flavonoids; Hypericum; In Vitro Techniques; Kinetin; Perylene; Phenols; Purines; Ultraviolet Rays | 2014 |
Successful in vivo tumor visualization using fluorescence laparoscopy in a mouse model of disseminated alveolar rhabdomyosarcoma.
Topics: Animals; Anthracenes; Apoptosis; Fluorescence; In Situ Nick-End Labeling; Laparoscopy; Mice; Mice, Inbred NOD; Neoplasms, Experimental; Perylene; Photochemotherapy; Protein Kinase C; Radiation-Sensitizing Agents; Rhabdomyosarcoma, Alveolar; Soft Tissue Neoplasms; Tumor Cells, Cultured | 2015 |
[In vitro effect of photoactivated hypericin on anti-Schistosoma japonicum adult male worms].
Topics: Animals; Anthracenes; Cercaria; In Vitro Techniques; Male; Mebendazole; Mice; Microscopy, Electron, Scanning; Perylene; Photochemical Processes; Schistosoma japonicum; Schistosomiasis japonica | 2014 |
Kinetics of incorporation/redistribution of photosensitizer hypericin to/from high-density lipoproteins.
Topics: Anthracenes; Cell Line; Chemistry, Pharmaceutical; Drug Liberation; Lipoproteins, HDL; Lipoproteins, LDL; Perylene; Photosensitizing Agents; Spectrometry, Fluorescence | 2014 |
Applicability of new degradable hypericin-polymer-conjugates as photosensitizers: principal mode of action demonstrated by in vitro models.
Topics: Anthracenes; Apoptosis; Cell Cycle Checkpoints; Cell Line; Drug Carriers; Endoplasmic Reticulum; Golgi Apparatus; Humans; Light; Lysosomes; Organophosphorus Compounds; Perylene; Photosensitizing Agents; Polymers | 2014 |
Hypericin biosynthesis in Hypericum hookerianum Wight and Arn: investigation on biochemical pathways using metabolite inhibitors and suppression subtractive hybridization.
Topics: Anthracenes; Emodin; Fosfomycin; Glycine; Glyphosate; Hypericum; Indoleacetic Acids; Lovastatin; Perylene; Plant Shoots; Polyketide Synthases; Tissue Culture Techniques | 2014 |
Effect of PKCα expression on Bcl-2 phosphorylation and cell death by hypericin.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Cell Survival; Gene Expression; Humans; Mitochondria; Necrosis; Perylene; Phosphorylation; Photosensitizing Agents; Protein Kinase C-alpha; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Serine | 2014 |
Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani.
Topics: Animals; Anthracenes; Antiprotozoal Agents; Enzyme Inhibitors; Glutathione; Leishmania donovani; Macrophages; Oxidation-Reduction; Perylene; Reactive Oxygen Species; Spermidine; Spermidine Synthase | 2015 |
Does hypericin boost the efficacy of high-power laser? A preliminary experimental study on rats.
Topics: Animals; Anthracenes; Lasers, Solid-State; Male; Models, Animal; Muscle, Skeletal; Perylene; Radiation-Sensitizing Agents; Random Allocation; Rats, Wistar; Thigh; Time Factors | 2014 |
Evaluation of hypericin: effect of aggregation on targeting biodistribution.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Autoradiography; Dimethyl Sulfoxide; Drug Compounding; Drug Stability; Hydrophobic and Hydrophilic Interactions; Infarction; Iodine Radioisotopes; Liver; Liver Cirrhosis, Experimental; Male; Necrosis; Perylene; Pharmaceutical Vehicles; Radionuclide Imaging; Rats, Sprague-Dawley; Solubility; Tissue Distribution; Whole Body Imaging | 2015 |
The complex of hypericin with β-lactoglobulin has antimicrobial activity with potential applications in dairy industry.
Topics: Animals; Anthracenes; Anti-Infective Agents; Binding Sites; Dairying; Disinfection; Fluorescence; Lactoglobulins; Models, Molecular; Perylene; Photochemotherapy; Photosensitizing Agents; Protein Binding; Staphylococcus aureus | 2015 |
Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models.
Topics: Animals; Anthracenes; Antineoplastic Agents; Autoradiography; Carcinoma, Hepatocellular; Cell Line, Tumor; Injections, Intralesional; Iodine Radioisotopes; Liver Neoplasms; Mice; Microscopy, Fluorescence; Necrosis; Perylene; Rats; Sarcoma; Theranostic Nanomedicine; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2015 |
The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages.
Topics: Anthracenes; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Cell Survival; Cytochromes c; Cytosol; Humans; Macrophages; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Mitochondria; Perylene; Poly(ADP-ribose) Polymerases; Radiation-Sensitizing Agents; Reactive Oxygen Species; Ultrasonic Therapy | 2015 |
Evaluation of the therapeutic efficacy of sequential therapy involving percutaneous microwave ablation in combination with 131I-hypericin using the VX2 rabbit breast solid tumor model.
Topics: Ablation Techniques; Animals; Anthracenes; Antineoplastic Agents; Carcinoma; Drug Evaluation, Preclinical; Female; Mammary Neoplasms, Experimental; Microwaves; Perylene; Rabbits; Radiosurgery; Tissue Distribution | 2015 |
Antimicrobial photodynamic activity of hypericin against methicillin-susceptible and resistant Staphylococcus aureus biofilms.
Topics: Anthracenes; Biofilms; Colony Count, Microbial; Light; Methicillin-Resistant Staphylococcus aureus; Microbial Viability; Perylene; Photochemotherapy; Photosensitizing Agents; Staphylococcus aureus | 2015 |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Hypericum; Inflammation; Male; Mice; Oxidative Stress; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rutin; Terpenes; Tumor Necrosis Factor-alpha | 2015 |
Phototoxic effect of hypericin alone and in combination with acetylcysteine on Staphylococcus aureus biofilms.
Topics: Acetylcysteine; Anthracenes; Biofilms; Drug Therapy, Combination; Perylene; Photochemotherapy; Photosensitizing Agents; Polysaccharides, Bacterial; Staphylococcus aureus | 2015 |
Photodynamic efficiency of hypericin compared with chlorin and hematoporphyrin derivatives in HEp-2 and Vero epithelial cell lines.
Topics: Animals; Anthracenes; Cell Line; Cell Survival; Chlorocebus aethiops; Fluorescence; Hematoporphyrin Derivative; Humans; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Perylene; Photochemotherapy; Photosensitizing Agents; Porphyrins; Serum Albumin, Bovine; Vero Cells | 2015 |
Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phytochemicals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Biliary and duodenal drainage for reducing the radiotoxic risk of antineoplastic 131I-hypericin in rat models.
Topics: Animals; Anthracenes; Bile; Common Bile Duct; Drainage; Duodenum; Iodine Radioisotopes; Male; Perylene; Radiation Injuries; Radiopharmaceuticals; Rats; Rats, Wistar | 2015 |
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model.
Topics: Amino Acids; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Chromatography, Liquid; Corticosterone; Depression; Disease Models, Animal; Male; Neurotransmitter Agents; Perylene; Rats; Stress, Psychological; Tandem Mass Spectrometry; Venlafaxine Hydrochloride | 2015 |
Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: focus on ABC transporters, GDF-15 and redox status.
Topics: Anthracenes; ATP-Binding Cassette Transporters; Caspase 3; Cell Death; Cell Line, Tumor; Drug Synergism; Glutathione; Growth Differentiation Factor 15; Humans; Indoles; Membrane Potential, Mitochondrial; Neoplasms; Oxidation-Reduction; Perylene; Photochemotherapy; Photosensitizing Agents; RNA, Small Interfering | 2015 |
Permeation Characteristics of Hypericin across Caco-2 Monolayers in the Absence or Presence of Quercitrin - A Mass Balance Study.
Topics: Anthracenes; Biological Transport; Caco-2 Cells; Cell Membrane; Cell Survival; Humans; Hypericum; Molecular Structure; Molecular Weight; Perylene; Quercetin; Solubility | 2015 |
Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models.
Topics: Animals; Anthracenes; Autoradiography; Disease Models, Animal; Iodine Radioisotopes; Necrosis; Neoplasms; Neovascularization, Pathologic; Perylene; Rabbits; Radiopharmaceuticals; Random Allocation; Tomography, Emission-Computed, Single-Photon | 2015 |
Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model.
Topics: Adult; Anthracenes; Apoptosis; Cell Survival; Humans; Infant, Newborn; Intracellular Space; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Skin; Tumor Microenvironment | 2015 |
Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies.
Topics: Animals; Anthracenes; Cell Line; Cricetinae; Humans; Leishmania; Leishmaniasis, Cutaneous; Perylene; Photochemotherapy; Photosensitizing Agents; U937 Cells; Wound Healing | 2015 |
Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio.
Topics: Animals; Anthracenes; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Insulinoma; MAP Kinase Kinase 4; Pancreatic Neoplasms; Perylene; Phosphorylation; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Rats | 2015 |
[Effect of Hypericin on the Function of the Neuroretina: An Electroretinographic Study].
Topics: Animals; Anthracenes; Cattle; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electroretinography; In Vitro Techniques; Light; Perylene; Photic Stimulation; Photoreceptor Cells, Vertebrate; Retinal Pigment Epithelium | 2015 |
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.
Topics: Anthracenes; Anthraquinones; Antiviral Agents; Cell Line; Hepacivirus; Hepatitis C; Humans; Perylene; RNA Helicases; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication | 2015 |
Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Calreticulin; Cancer Vaccines; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Immunotherapy; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mitoxantrone; Neoplasms; Ovarian Neoplasms; Perylene; Phagocytes; Phagocytosis; Phenotype; Photochemotherapy; Prognosis; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 2015 |
Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspase 9; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Light; MAP Kinase Kinase 4; Perylene; Photochemotherapy; Photosensitizing Agents; Signal Transduction | 2015 |
Intracellular localization and dynamics of Hypericin loaded PLLA nanocarriers by image correlation spectroscopy.
Topics: Anthracenes; Biological Transport; Cell Line, Tumor; Coumarins; Drug Carriers; Fluorescent Dyes; Humans; Lactic Acid; Nanoparticles; Perylene; Polyesters; Polymers; Spectrum Analysis; Thiazoles | 2015 |
Co-delivery of siRNA and hypericin into cancer cells by hyaluronic acid modified PLGA-PEI nanoparticles.
Topics: Anthracenes; Carcinoma; Cell Line, Tumor; Humans; Hyaluronic Acid; Hypoxia-Inducible Factor 1, alpha Subunit; Imines; Nanoparticles; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Particle Size; Perylene; Polyesters; Polyethylenes; RNA, Small Interfering; Transfection | 2016 |
Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses.
Topics: Animals; Anthracenes; Iodine Radioisotopes; Liver; Muscle, Skeletal; Myocardial Infarction; Myocardium; Necrosis; Perylene; Rats; Tomography, Emission-Computed, Single-Photon | 2016 |
Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.
Topics: Animals; Anthracenes; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Drug Design; Emodin; Humans; Hydrogen Peroxide; Iodine Radioisotopes; Lung Neoplasms; Male; Necrosis; Perylene; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2016 |
Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; RNA, Neoplasm; Terpenes; Tetrazolium Salts; Thiazoles | 2016 |
Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin.
Topics: Anthracenes; Antineoplastic Agents; Erythrocytes; Glutathione S-Transferase pi; Humans; Kinetics; Perylene | 2015 |
[Pharmacognosy study of Verbascum species].
Topics: Anthracenes; Chromatography, Thin Layer; Flavonoids; Flowers; Hemolysis; Perylene; Pharmacognosy; Plants, Medicinal; Quercetin; Rutin; Saponins; Verbascum | 2015 |
Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy.
Topics: Anthracenes; Cell Death; Chromatography, High Pressure Liquid; Dextrans; Drug Delivery Systems; Humans; Jurkat Cells; Magnetics; Magnetite Nanoparticles; Particle Size; Perylene; Photochemotherapy; Reactive Oxygen Species; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Static Electricity; X-Ray Diffraction | 2015 |
An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template".
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Molecular Imprinting; Perylene; Plant Extracts; Solid Phase Extraction; Spectroscopy, Fourier Transform Infrared | 2016 |
Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis.
Topics: Anthracenes; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Cytokines; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Light; Membrane Potential, Mitochondrial; Perylene; Phosphatidylinositol 3-Kinases; Photochemotherapy; Proto-Oncogene Proteins c-akt; Radiation-Sensitizing Agents; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vascular Endothelial Growth Factor A | 2015 |
Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism.
Topics: Anthracenes; Apoptosis; Colorectal Neoplasms; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Glutathione; HCT116 Cells; Humans; Intracellular Space; Multidrug Resistance-Associated Protein 2; Organoplatinum Compounds; Oxaliplatin; Perylene; Photochemotherapy | 2016 |
Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging.
Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2016 |
Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium.
Topics: Animals; Anthracenes; Anthraquinones; Chromatography, High Pressure Liquid; Iodine Radioisotopes; Male; Mice; Multimodal Imaging; Myocardial Infarction; Myocardium; Necrosis; Perylene; Radiochemistry; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2016 |
Photoactivated hypericin is not genotoxic.
Topics: Anthracenes; Cells, Cultured; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Radiation; Humans; Lymphocytes; Mutagenicity Tests; Mutation; Perylene; Photosensitizing Agents; Radiation Dosage | 2016 |
Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma.
Topics: Adaptive Immunity; Animals; Anthracenes; Apoptosis; Brain Neoplasms; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Death; Dendritic Cells; Endoplasmic Reticulum Stress; Glioma; Mice; Mice, Inbred C57BL; Neoplasm Grading; Perylene; Photochemotherapy; Reactive Oxygen Species; T-Lymphocytes, Cytotoxic | 2016 |
Deeper insights into the drug defense of glioma cells against hydrophobic molecules.
Topics: Anthracenes; Anthraquinones; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Nucleus; Cholesterol, LDL; DNA; Emodin; Glioma; Humans; Hydrophobic and Hydrophilic Interactions; Light; Molecular Docking Simulation; Perylene; Serum Albumin | 2016 |
Application of mathematical models for bacterial inactivation curves using Hypericin-based photosensitization.
Topics: Anthracenes; Bacillus cereus; Decontamination; Food Microbiology; Light; Listeria monocytogenes; Models, Biological; Perylene; Radiation-Sensitizing Agents | 2016 |
Shoot Tip Meristem Cryopreservation of Hypericum Species.
Topics: Acclimatization; Anthracenes; Chromatography, High Pressure Liquid; Chromosomes, Plant; Cryopreservation; Cryoprotective Agents; Cytogenetic Analysis; Flow Cytometry; Hypericum; Meristem; Perylene; Plant Shoots; Ploidies; Vitrification | 2016 |
Construction of Hypericin Gland-Specific cDNA Library via Suppression Subtractive Hybridization.
Topics: Anthracenes; Biosynthetic Pathways; DNA, Complementary; Gene Library; Germination; Hypericum; Perylene; Polymerase Chain Reaction; RNA, Messenger; RNA, Plant; Subtractive Hybridization Techniques | 2016 |
Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation.
Topics: Anthracenes; Antiprotozoal Agents; Cyclophilins; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Heat-Shock Proteins; Leishmania donovani; Life Cycle Stages; Molecular Sequence Annotation; Peptide Chain Initiation, Translational; Perylene; Proteome; Protozoan Proteins; Ribosomal Proteins; RNA-Binding Proteins; Spermidine; Ubiquitin | 2016 |
Estimation of PKCδ autophosphorylation in U87 MG glioma cells: combination of experimental, conceptual and numerical approaches.
Topics: Anthracenes; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Ceramides; Computer Simulation; Glioma; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Optical Imaging; Perylene; Phosphorylation; Protein Kinase C-delta; Signal Transduction; Spectrum Analysis; Time Factors | 2017 |
Fluorescence Detection of DNA Based on Non-covalent π-π Stacking Interaction between 1-Pyrenebutanoic Acid and Hypericin.
Topics: Anthracenes; Biosensing Techniques; DNA; Fluorescence; Magnetic Fields; Molecular Structure; Perylene; Photosensitizing Agents; Pyrenes | 2016 |
YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anthracenes; Antineoplastic Agents; Autophagy; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Drug Resistance, Neoplasm; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Membrane Potential, Mitochondrial; Naphthoquinones; Perylene; Photochemotherapy; Photosensitizing Agents; Survivin | 2016 |
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Cytochrome P-450 CYP3A; Firefly Luciferin; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Perylene; Phloroglucinol; Real-Time Polymerase Chain Reaction; Terpenes | 2016 |
Improved therapeutic outcomes of thermal ablation on rat orthotopic liver allograft sarcoma models by radioiodinated hypericin induced necrosis targeted radiotherapy.
Topics: Allografts; Animals; Anthracenes; Cell Line, Tumor; Combined Modality Therapy; Hyperthermia, Induced; Iodine Radioisotopes; Liver Neoplasms, Experimental; Male; Necrosis; Perylene; Radiation-Sensitizing Agents; Radiotherapy; Rats; Rats, Sprague-Dawley; Sarcoma; Treatment Outcome | 2016 |
Anti- and Pro-apoptotic Bcl2 Proteins Distribution and Metabolic Profile in Human Coronary Aorta Endothelial Cells Before and After HypPDT.
Topics: Anthracenes; Aorta; Apoptosis Regulatory Proteins; Cell Survival; Endothelial Cells; Humans; Immunohistochemistry; Metabolome; Microscopy, Fluorescence; Mitochondria; Oxidative Stress; Perylene; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2016 |
Hypericin fluorescence kinetics in the presence of low density lipoproteins: study on quail CAM assay for topical delivery.
Topics: Administration, Topical; Animals; Anthracenes; Biological Assay; Cell Line, Tumor; Chorioallantoic Membrane; Fluorescence; Fluorescent Dyes; Humans; Kinetics; Lipoproteins, LDL; Metabolic Clearance Rate; Neoplasms, Experimental; Perylene; Quail | 2016 |
Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent.
Topics: Animals; Anthracenes; Cholesterol; Chromatography, High Pressure Liquid; Diagnosis, Differential; Fluorescence; Gallstones; Humans; Male; Optical Imaging; Perylene; Rats; Rats, Wistar | 2016 |
Antifungal properties of hypericin, hypericin tetrasulphonic acid and fagopyrin on pathogenic fungi and spoilage yeasts.
Topics: Anthracenes; Antifungal Agents; Candida albicans; Humans; Microbial Sensitivity Tests; Perylene; Plant Extracts; Quinones; Sulfonic Acids; Trichophyton | 2016 |
Semi-synthesis and PDT activities of a new amphiphilic chlorin derivative.
Topics: Anthracenes; Cell Death; Chlorophyll; HeLa Cells; Humans; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents | 2017 |
Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer's disease by suppressing MKL1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Cell Line; Cognition; Cognition Disorders; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Peptide Fragments; Perylene; Trans-Activators; Treatment Outcome | 2016 |
A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells.
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Dacarbazine; Humans; Melanoma; Neoplasm Metastasis; Perylene; Photochemotherapy; Skin Neoplasms | 2017 |
Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy.
Topics: 2-Methoxyestradiol; Adenocarcinoma; Anthracenes; Breast Neoplasms; Cell Line, Tumor; Estradiol; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Light; Perylene; Photochemotherapy; Photosensitizing Agents; RNA, Messenger; Superoxide Dismutase; Up-Regulation | 2017 |
Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate.
Topics: Anthracenes; Flowers; Hypericum; Mycorrhizae; Perylene; Phloroglucinol; Phosphorus; Plant Extracts; Terpenes | 2017 |
Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB.
Topics: Adenylate Kinase; Anthracenes; Apoptosis; ATP Binding Cassette Transporter 1; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; CD36 Antigens; Cell Line; Cell Nucleus; Cytoprotection; Humans; Lipid Metabolism; Lipids; Lysosomes; Macrophages; Perylene; Protein Transport; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Scavenger Receptors, Class A; Signal Transduction; TOR Serine-Threonine Kinases; Ultrasonics | 2016 |
Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Cell Respiration; Endothelial Cells; Glioma; Glycolysis; Humans; Light; Membrane Potential, Mitochondrial; Oxidative Stress; Perylene; Photosensitizing Agents | 2017 |
The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells.
Topics: Algorithms; Anthracenes; Apoptosis; Brain Neoplasms; Catalytic Domain; Cell Line, Tumor; Glioma; Humans; Light; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Oxidative Stress; Perylene; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-bcl-2 | 2017 |
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy.
Topics: Anthracenes; Breast Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Glutathione; Glutathione Peroxidase; Glutathione S-Transferase pi; Humans; MCF-7 Cells; Perylene; Phospholipid Hydroperoxide Glutathione Peroxidase; Photochemotherapy | 2017 |
One-pot method to prepare a theranostic nanosystem with magnetic resonance imaging function and anticancer activity through multiple mechanisms.
Topics: Adenosine Triphosphate; Anthracenes; Antineoplastic Agents; Coordination Complexes; Gadolinium; HeLa Cells; Humans; Magnetic Resonance Imaging; Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Theranostic Nanomedicine | 2017 |
Permeation characteristics of hypericin across Caco-2 monolayers in the presence of single flavonoids, defined flavonoid mixtures or Hypericum extract matrix.
Topics: Anthracenes; Caco-2 Cells; Flavonoids; Humans; Hypericum; Intestinal Absorption; Permeability; Perylene; Plant Extracts | 2019 |
Formation of Large Hypericin Aggregates in Giant Unilamellar Vesicles-Experiments and Modeling.
Topics: Anthracenes; Diffusion; Models, Molecular; Molecular Conformation; Perylene; Phosphatidylcholines; Unilamellar Liposomes | 2017 |
Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation.
Topics: Acetophenones; Angiogenesis Inhibitors; Anthracenes; Antineoplastic Agents; Apoptosis; Benzopyrans; Cell Line, Tumor; Cell Survival; Gene Expression Regulation; Glioma; Humans; Light; Perylene; Photochemotherapy; Protein Kinase C-delta; Radiation-Sensitizing Agents | 2017 |
Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy.
Topics: Animals; Anthracenes; Apoptosis; Autophagy; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Female; HCT116 Cells; Humans; Mice; Organoplatinum Compounds; Oxaliplatin; Perylene; Photosensitizing Agents; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2017 |
Radioiodinated hypericin disulfonic acid sodium salts as a DNA-binding probe for early imaging of necrotic myocardium.
Topics: Animals; Anthracenes; Cattle; Cell Line; Cell Survival; DNA; Heart; Iodine Radioisotopes; Male; Mice; Myocardium; Necrosis; Perylene; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonic Acids | 2017 |
Optimized and Validated HPLC Analysis of St. John's Wort Extract and Final Products by Simultaneous Determination of Major Ingredients.
Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drug Stability; Hypericum; Linear Models; Perylene; Plant Extracts; Quercetin; Reproducibility of Results; Rutin; Sensitivity and Specificity | 2017 |
Molecular events leading to death of Leishmania donovani under spermidine starvation after hypericin treatment.
Topics: Adenosine Triphosphate; Anthracenes; Gene Expression Regulation; Humans; Leishmania donovani; Leishmaniasis, Visceral; NAD; Perylene; Spermidine; Trypanocidal Agents | 2017 |
Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Chromatin; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; DNA Methylation; Drug Resistance, Neoplasm; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Perylene; Phenylbutyrates; Photochemotherapy; Valproic Acid | 2017 |
Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy.
Topics: Administration, Intravenous; Anthracenes; Cell Death; Cell Proliferation; Colonic Neoplasms; Drug Delivery Systems; HT29 Cells; Humans; Jurkat Cells; Leukemia, T-Cell; Magnetite Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Tumor Cells, Cultured | 2017 |
Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy.
Topics: Acrylic Resins; Animals; Anthracenes; Drug Delivery Systems; Drug Liberation; Gels; Intestinal Absorption; Mechanical Phenomena; Perylene; Photochemotherapy; Photosensitizing Agents; Poloxamer; Rats; Rheology; Skin Absorption; Swine; Tissue Adhesions | 2017 |
Phototoxicity in a laryngeal cancer cell line enhanced by a targeting amphiphilic chlorin photosensitizer.
Topics: Anthracenes; Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Porphyrins | 2017 |
Investigating the effect of poly-l-lactic acid nanoparticles carrying hypericin on the flow-biased diffusive motion of HeLa cell organelles.
Topics: Anthracenes; Diffusion; Drug Carriers; Endosomes; Fluorescence; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Lysosomes; Mitochondria; Nanoparticles; Organelles; Perylene; Photosensitizing Agents; Polyesters; Spectrum Analysis | 2019 |
Chemometric evaluation of hypericin and related phytochemicals in 17 in vitro cultured Hypericum species, hairy root cultures and hairy root-derived transgenic plants.
Topics: Anthracenes; Chromatography, Liquid; Hypericum; Mass Spectrometry; Perylene; Phytochemicals; Plant Extracts; Plant Leaves; Plant Roots; Plants, Genetically Modified; Principal Component Analysis; Secondary Metabolism | 2019 |
Deciphering the photosensitization mechanisms of hypericin towards biological membranes.
Topics: Anthracenes; Light; Lipid Bilayers; Molecular Dynamics Simulation; Perylene; Quantum Theory; Singlet Oxygen | 2017 |
Comparative in vitro study of photodynamic activity of hypericin and hypericinates in MCF-7 cells.
Topics: Anthracenes; Apoptosis; Cell Nucleus; Cell Survival; Humans; Light; MCF-7 Cells; Microscopy, Fluorescence; Mitochondria; Perylene; Photosensitizing Agents; Singlet Oxygen | 2017 |
Synthesis of calcium phosphate nanostructures by combustion in solution as a potential encapsulant system of drugs with photodynamic properties for the treatment of cutaneous leishmaniasis.
Topics: Anthracenes; Calcium Phosphates; Humans; Leishmaniasis, Cutaneous; Macrophages; Microscopy, Electron, Scanning; Nanostructures; Particle Size; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Spectrometry, Fluorescence; X-Ray Diffraction | 2018 |
Strong antimicrobial activity of Hypericum perforatum L. against oral isolates of Lactobacillus spp.
Topics: Anthracenes; Anti-Infective Agents; Cell Line; Gingiva; Humans; Hypericum; Lactobacillus; Microbial Sensitivity Tests; Perylene; Plant Extracts | 2017 |
Excitation of triplet states of hypericin in water mediated by hydrotropic cromolyn sodium salt.
Topics: Anthracenes; Cromolyn Sodium; Macromolecular Substances; Perylene; Radiation-Sensitizing Agents; Solubility; Spectrometry, Fluorescence | 2018 |
Reduction of cancer cell viability by synergistic combination of photodynamic treatment with the inhibition of the Id protein family.
Topics: Anthracenes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; Dihematoporphyrin Ether; Drug Synergism; Humans; Inhibitor of Differentiation Protein 1; Light; MCF-7 Cells; Nanostructures; Peptides, Cyclic; Perylene; Photosensitizing Agents; Porphyrins | 2018 |
St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway.
Topics: AMP-Activated Protein Kinases; Anthracenes; Breast Neoplasms; Cell Line, Tumor; Humans; Hypericum; MCF-7 Cells; Perylene; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Optimized protocol for multigram preparation of emodin anthrone, a precursor in the hypericin synthesis.
Topics: Anthracenes; Anthraquinones; Emodin; Hypericum; Perylene; Radiation-Sensitizing Agents; Reducing Agents | 2019 |
Methodological aspects of biologically active compounds quantification in the genus Hypericum.
Topics: Anthracenes; Catechin; Chlorogenic Acid; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Plant Stems; Quercetin; Rutin; Terpenes | 2018 |
Relation between hypericin content and morphometric leaf parameters in Hypericum spp.: A case of cubic degree polynomial function.
Topics: Anthracenes; Hypericum; Models, Biological; Perylene; Plant Leaves | 2018 |
Mechanistic and structural insights into the in vitro inhibitory action of hypericin on glutathione reductase purified from baker's yeast.
Topics: Anthracenes; Catalytic Domain; Glutathione Reductase; Perylene; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2018 |
Hypericin affects cancer side populations via competitive inhibition of BCRP.
Topics: Aldehyde Dehydrogenase; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Clone Cells; Humans; Mice, SCID; Neoplasm Proteins; Neoplasms; Neoplastic Stem Cells; Perylene; Phenotype; Side-Population Cells; Spheroids, Cellular; Substrate Specificity; Survival Analysis | 2018 |
Solution-combustion synthesis of doped TiO
Topics: Animals; Anthracenes; Cell Survival; DNA Damage; Iron; Leishmania; Leishmaniasis; Macrophages, Peritoneal; Metal Nanoparticles; Mice; Microscopy, Electron, Transmission; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Spectrometry, Fluorescence; Titanium; Ultraviolet Rays; X-Ray Diffraction; Zinc | 2018 |
Distinct Hypericum perforatum L. total extracts exert different antitumour activity on erythroleukemic K562 cells.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Flowers; Humans; Hypericum; K562 Cells; Perylene; Plant Extracts; Solvents | 2018 |
Natural zeolite for adsorbing and release of functional materials.
Topics: Achilles Tendon; Adsorption; Animals; Anthracenes; Cattle; Collagen; Coloring Agents; Magnetite Nanoparticles; Microscopy, Fluorescence, Multiphoton; Perylene; Zeolites | 2018 |
Topically applied hypericin exhibits skin penetrability on nude mice.
Topics: Administration, Topical; Animals; Anthracenes; Male; Mice, Nude; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Platelet Endothelial Cell Adhesion Molecule-1; Skin; Skin Absorption | 2018 |
Effect of photodynamic inactivation of Escherichia coli by hypericin.
Topics: Anthracenes; Escherichia coli; Perylene; Photosensitivity Disorders; Reactive Oxygen Species | 2018 |
Inhibiting ABCG2 could potentially enhance the efficacy of hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer.
Topics: Anthracenes; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Delivery Systems; HCT116 Cells; HT29 Cells; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Spheroids, Cellular | 2018 |
Hypericin-functionalized graphene oxide for enhanced mitochondria-targeting and synergistic anticancer effect.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disulfides; Doxorubicin; Drug Screening Assays, Antitumor; Endocytosis; Female; Glutathione; Graphite; Humans; Ligands; MCF-7 Cells; Mice; Mitochondria; Permeability; Perylene; Photosensitizing Agents; Spectroscopy, Fourier Transform Infrared | 2018 |
Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins.
Topics: Administration, Intravenous; Animals; Anthracenes; Cell Line, Tumor; Chickens; Chorioallantoic Membrane; Drug Delivery Systems; Hydrophobic and Hydrophilic Interactions; Lipoproteins, LDL; Perylene; Photochemotherapy; Photosensitizing Agents; Spectrometry, Fluorescence | 2018 |
The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29).
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Movement; Colonic Neoplasms; Drug Resistance, Neoplasm; HT29 Cells; Humans; Neoplasm Metastasis; Oxaliplatin; Perylene; Phloroglucinol; Terpenes | 2018 |
Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy.
Topics: Anthracenes; Apoptosis; Endocytosis; Fluorescence; Hep G2 Cells; Humans; Indoles; Lactose; Magnetics; MCF-7 Cells; Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Polymers; Reactive Oxygen Species; Static Electricity; Toxicity Tests | 2018 |
Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1.
Topics: Anthracenes; Antiviral Agents; Cell Line, Tumor; Down-Regulation; Heme Oxygenase-1; Hepacivirus; Humans; Perylene; Viral Nonstructural Proteins; Virus Replication | 2018 |
Hypericin-assisted photodynamic therapy against anaplastic thyroid cancer.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Mice; Mitophagy; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2018 |
[In vitro Effect of Hypericin against Toxoplasma gondii Tachyzoites].
Topics: Anthracenes; Microscopy, Electron, Transmission; Perylene; Toxoplasma | 2016 |
Hypericin Induces Apoptosis in MDA-MB-175-VII Cells in Lower Dose Compared to MDA-MB-231.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Female; Gene Expression Regulation, Neoplastic; Humans; Perylene; Tumor Suppressor Protein p53 | 2018 |
Phenotyping the genus Hypericum by secondary metabolite profiling: emodin vs. skyrin, two possible key intermediates in hypericin biosynthesis.
Topics: Anthracenes; Anthraquinones; Chromatography, Liquid; Emodin; Hypericum; Mass Spectrometry; Perylene; Phenotype; Plant Leaves; Secondary Metabolism | 2018 |
Selective Photodynamic Effects on Breast Cancer Cells Provided by p123 Pluronic®- Based Nanoparticles Modulating Hypericin Delivery.
Topics: Anthracenes; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Humans; Micelles; Molecular Structure; Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Poloxalene; Structure-Activity Relationship | 2020 |
Hypericin-glucamine antimicrobial photodynamic therapy in the progression of experimentally induced periodontal disease in rats.
Topics: Animals; Anthracenes; Disease Models, Animal; Disease Progression; Male; Maxilla; Molar; Periodontal Diseases; Perylene; Photochemotherapy; Photosensitizing Agents; Random Allocation; Rats; Tomography, X-Ray Computed | 2019 |
On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Anti-Inflammatory Agents; Binding, Competitive; Computer Simulation; Hypericum; Janus Kinase 1; Janus Kinase Inhibitors; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Perylene; Plant Extracts | 2018 |
Hypericin photodynamic activity. Part III: in vitro evaluation in different nanocarriers against trypomastigotes of Trypanosoma cruzi.
Topics: Anthracenes; Drug Carriers; Micelles; Nanostructures; Perylene; Poloxamer; Trypanosoma cruzi | 2019 |
Breast cancer resistance protein is the enemy of hypericin accumulation and toxicity of hypericin-mediated photodynamic therapy.
Topics: Anthracenes; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; HL-60 Cells; Humans; Neoplasm Proteins; Perylene; Photochemotherapy; Radiation-Sensitizing Agents | 2019 |
Benefits of hypericin transport and delivery by low- and high-density lipoproteins to cancer cells: From in vitro to ex ovo.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Humans; Hydrophobic and Hydrophilic Interactions; Lipoproteins, HDL; Lipoproteins, LDL; Perylene; Photochemotherapy; Photosensitizing Agents; Quail; Spectrometry, Fluorescence | 2019 |
Phytochemical Profiles and Antibacterial Activities of Hydroalcoholic Extracts of Origanum vulgare and Hypericum perforatum and Carvacrol and Hypericin as a Promising Anti-Staphylococcus aureus.
Topics: Anthracenes; Anti-Bacterial Agents; Candida albicans; Chromatography, High Pressure Liquid; Cymenes; Escherichia coli; Hypericum; Microbial Sensitivity Tests; Monoterpenes; Origanum; Perylene; Phytochemicals; Plant Extracts; Solid Phase Microextraction; Staphylococcus aureus | 2019 |
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Membrane; Glioblastoma; Hydrocortisone; Hypericum; Membrane Fluidity; Perylene; Phloroglucinol; Phosphatidylethanolamines; Plant Extracts; Quercetin; Rats; Receptors, Adrenergic, beta-1; Signal Transduction; Terpenes | 2019 |
Photodynamic therapy - hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Chickens; Chorioallantoic Membrane; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Liposomes; Ovarian Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents | 2019 |
Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Human T-lymphotropic virus 1; Humans; Leukemia-Lymphoma, Adult T-Cell; Light; Models, Biological; Perylene; Photochemotherapy; Photosensitizing Agents; Transcription, Genetic; Tumor Stem Cell Assay | 2019 |
Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery.
Topics: Allografts; Anthracenes; Butyrates; Colforsin; Fatty Liver; Feasibility Studies; Female; Humans; Lipid Metabolism; Liver; Liver Transplantation; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Organ Preservation; Perfusion; Perylene; Pharmaceutical Solutions; Phenylurea Compounds; Reperfusion Injury; Thiazoles; Tissue and Organ Harvesting | 2019 |
Hypericin-Apomyoglobin: An Enhanced Photosensitizer Complex for the Treatment of Tumor Cells.
Topics: Anthracenes; Antineoplastic Agents; Apoproteins; Cell Survival; Drug Carriers; HeLa Cells; Humans; Myoglobin; Perylene; Photosensitizing Agents; Spheroids, Cellular | 2019 |
Encapsulation of anticancer drug curcumin and co-loading with photosensitizer hypericin into lipoproteins investigated by fluorescence resonance energy transfer.
Topics: Anthracenes; Antineoplastic Agents; Curcumin; Drug Delivery Systems; Fluorescence Resonance Energy Transfer; Lipoproteins, HDL; Lipoproteins, LDL; Perylene; Photosensitizing Agents | 2019 |
Temperature-dependent growth and hypericin biosynthesis in Hypericum perforatum.
Topics: Anthracenes; Hypericum; Perylene; Plant Leaves; Plant Proteins; Temperature | 2019 |
Discovery of key regulators of dark gland development and hypericin biosynthesis in St. John's Wort (Hypericum perforatum).
Topics: Anthracenes; Flavonoids; Genes, Plant; Hypericum; Metabolome; Perylene; Transcriptome | 2019 |
Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin.
Topics: Anthracenes; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hypericum; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Perylene; Plant Extracts; Proteolysis; Structure-Activity Relationship | 2019 |
Host metabolite producing endophytic fungi isolated from Hypericum perforatum.
Topics: Anthracenes; Anti-Infective Agents; Chloroform; Chromatography, High Pressure Liquid; Emodin; Fermentation; Fungi, Unclassified; Hypericum; Industrial Microbiology; Methanol; Microbial Sensitivity Tests; Perylene; Phylogeny; Plant Extracts; Plants, Medicinal; Secondary Metabolism; Staphylococcus aureus; Streptomyces; Tandem Mass Spectrometry | 2019 |
Hypericin-Loaded Carbon Nanohorn Hybrid for Combined Photodynamic and Photothermal Therapy in Vivo.
Topics: Anthracenes; Carbon; Cell Line, Tumor; Cell Survival; HeLa Cells; Humans; Hyperthermia, Induced; Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species | 2019 |
From Protohypericin to Hypericin: Photoconversion Analysis Using a Time-Resolved Thermal Lens Technique.
Topics: Anthracenes; Lenses; Perylene; Photochemotherapy; Photosensitizing Agents | 2019 |
Ultrasound-assisted packed-bed extraction of hypericin from Hypericum perforatum L. and optimization by response surface methodology.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Ethanol; Hypericum; Methanol; Models, Chemical; Perylene; Reproducibility of Results; Solvents; Temperature; Time Factors; Ultrasonic Waves | 2019 |
An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy.
Topics: Adenocarcinoma; Anthracenes; Cell Membrane; Colonic Neoplasms; Computer Simulation; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; HT29 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Hypericum; Membrane Fluidity; Neoplasm Recurrence, Local; Perylene; Photochemotherapy; Photosensitizing Agents; Plant Extracts; Spin Labels | 2019 |
Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane.
Topics: Angiogenesis Inducing Agents; Animals; Anthracenes; Biomarkers; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Colorectal Neoplasms; Disease Models, Animal; Gene Expression; Humans; Neovascularization, Pathologic; Perylene; Phloroglucinol; Photochemotherapy; Photosensitizing Agents; Terpenes | 2019 |
Influence of the electron donor properties of hypericin on its sensitizing ability in DSSCs.
Topics: Anthracenes; Coloring Agents; Density Functional Theory; Electric Power Supplies; Electrons; Perylene; Solar Energy; Titanium | 2019 |
Effect of different quality of light on growth and production of secondary metabolites in adventitious root cultivation of Hypericum perforatum.
Topics: Anthracenes; Biomass; Culture Media; Flavonoids; Hypericum; Light; Perylene; Phenols; Plant Roots; Secondary Metabolism; Sugars | 2019 |
Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity.
Topics: Animals; Anthracenes; Antioxidants; Apoptosis; Cell Line; Cell Survival; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fatty Acids; Glucose; Homeodomain Proteins; Insulin-Secreting Cells; Insulinoma; Lipids; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Nitric Oxide; Perylene; Rats; Trans-Activators | 2019 |
Aromaticity and Electron Density of Hypericin.
Topics: Anthracenes; Electrons; Molecular Structure; Perylene; Quantum Theory | 2019 |
Synergistic effects of ultrasound and photodynamic therapy leading to biofilm eradication on polyurethane catheter surfaces modified with hypericin nanoformulations.
Topics: Anthracenes; Biofilms; Catheter-Related Infections; Cell Line; Central Venous Catheters; Humans; Materials Testing; Nanostructures; Perylene; Photochemotherapy; Polyurethanes; Reactive Oxygen Species; Staphylococcus; Surface Properties; Ultrasonics | 2019 |
Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells.
Topics: Animals; Anthracenes; Antiviral Agents; Apoptosis; Chick Embryo; Coronavirus Infections; Kidney; Perylene; Poultry Diseases; Protective Agents; Reactive Oxygen Species | 2019 |
Importance of Hypericin-Bcl2 interactions for biological effects at subcellular levels.
Topics: Aniline Compounds; Anthracenes; Cell Line, Tumor; Cell Survival; Fluorescence; Glioma; Humans; Molecular Docking Simulation; Molecular Structure; Perylene; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Tryptophan; Tyrosine | 2019 |
Hypericin inclusion complexes encapsulated in liposomes for antimicrobial photodynamic therapy.
Topics: Anthracenes; Anti-Bacterial Agents; beta-Cyclodextrins; Biofilms; Drug Compounding; Liposomes; Perylene; Phosphatidylethanolamines; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Staphylococcus saprophyticus | 2019 |
Hypericin-loaded graphene oxide protects ducks against a novel duck reovirus.
Topics: Animals; Anthracenes; Cell Line; Drug Carriers; Ducks; Graphite; Orthoreovirus, Avian; Perylene; Poultry Diseases; Reoviridae Infections | 2019 |
Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora.
Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Sicily; Species Specificity; Terpenes | 2020 |
Physicochemical stability of bioadhesive thermoresponsive platforms for methylene blue and hypericin delivery in photodynamic therapy.
Topics: Acrylates; Adhesives; Anthracenes; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Drug Stability; Humans; Methylene Blue; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Poloxamer; Temperature | 2020 |
Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo.
Topics: AMP-Activated Protein Kinases; Animals; Anthracenes; Apoptosis; Cell Differentiation; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Perylene; Reactive Oxygen Species | 2020 |
Hypericin: Single Molecule Spectroscopy of an Active Natural Drug.
Topics: Anthracenes; Cell Line, Tumor; Density Functional Theory; Fluorescence; Humans; Microscopy, Fluorescence; Models, Chemical; Perylene; Photosensitizing Agents; Single Molecule Imaging; Spectrum Analysis, Raman | 2020 |
Hypericin-mediated photoinactivation of polymeric nanoparticles against Staphylococcus aureus.
Topics: Anthracenes; Biofilms; Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents; Staphylococcus aureus | 2020 |
Naturally available hypericin undergoes electron transfer for type I photodynamic and photothermal synergistic therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Electrons; Female; HeLa Cells; Humans; Lasers; Male; Mice, Nude; Nanoparticles; Neoplasms; Perylene; Phosphatidylethanolamines; Photochemotherapy; Photothermal Therapy; Polyethylene Glycols; Radiation-Sensitizing Agents; Rats, Sprague-Dawley; Tumor Burden | 2020 |
Biodegradable Hypericin-Containing Nanoparticles for Necrosis Targeting and Fluorescence Imaging.
Topics: Animals; Anthracenes; Cell Line, Tumor; Female; Humans; Mice; Nanoparticles; Necrosis; Neoplasms; Optical Imaging; Perylene | 2020 |
Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cell Line; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Humans; Light; Macrophages; Oxaliplatin; Perylene; Phagocytosis; Polyenes; Polyunsaturated Alkamides | 2020 |
Carbon dot-assisted luminescence of singlet oxygen: the generation dynamics but not the cumulative amount of singlet oxygen is responsible for the photodynamic therapy efficacy.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carbon; Female; HeLa Cells; Humans; Imidazoles; Luminescence; Luminescent Agents; Methylene Blue; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Quantum Dots; Quinones; Singlet Oxygen | 2020 |
Exploring Modes of Photokilling by Hypericin.
Topics: Anthracenes; Apoptosis; Autophagy; Cell Line, Tumor; Humans; Lysosomes; Perylene; Photochemotherapy; Photosensitizing Agents | 2020 |
Evidence of hypericin photoinactivation of E. faecalis: From planktonic culture to mammalian cells selectivity up to biofilm disruption.
Topics: Animals; Anthracenes; Biofilms; Enterococcus faecalis; Perylene; Photochemotherapy; Photosensitizing Agents; Plankton | 2020 |
Searching for combination therapy by clustering methods: Stimulation of PKC in Golgi apparatus combined with hypericin induced PDT.
Topics: Anthracenes; Cell Line, Tumor; Cluster Analysis; Golgi Apparatus; Perylene; Photochemotherapy; Photosensitizing Agents | 2020 |
Selective photodynamic effects on cervical cancer cells provided by P123 Pluronic®-based nanoparticles modulating hypericin delivery.
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; HeLa Cells; Humans; Micelles; Nanoparticles; Neoplasm Invasiveness; Oxidative Stress; Perylene; Photochemotherapy; Poloxalene; Time Factors; Uterine Cervical Neoplasms | 2020 |
Targeting the SARS-CoV-2 spike glycoprotein prefusion conformation: virtual screening and molecular dynamics simulations applied to the identification of potential fusion inhibitors.
Topics: Anthracenes; Antiviral Agents; Betacoronavirus; Binding Sites; Coronavirus Infections; COVID-19; Gene Expression; Heterocyclic Compounds, 4 or More Rings; High-Throughput Screening Assays; Humans; Indoles; Isoindoles; Molecular Docking Simulation; Molecular Dynamics Simulation; Pandemics; Perylene; Pneumonia, Viral; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; SARS-CoV-2; Small Molecule Libraries; Spike Glycoprotein, Coronavirus; Sulfonamides; Thermodynamics; User-Computer Interface; Virus Internalization | 2020 |
Hypericin Accumulation as a Determinant of PDT Efficacy.
Topics: Animals; Anthracenes; Cell Line, Tumor; Humans; Lung Neoplasms; Mice; Perylene; Photochemotherapy; Photosensitizing Agents | 2020 |
Hypericin Ameliorates Maternal Separation-Induced Cognitive Deficits and Hippocampal Inflammation in Rats.
Topics: Administration, Oral; Animals; Anthracenes; Cognitive Dysfunction; Dopamine; Hippocampus; Inflammation; Male; Maternal Deprivation; Perylene; Rats; Rats, Wistar | 2021 |
Desensitization of metastatic melanoma cells to therapeutic treatment through repeated exposure to dacarbazine.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation; Humans; Melanoma; Neoplasm Proteins; Perylene; Photochemotherapy; Photosensitizing Agents | 2020 |
MALDI-HRMS Imaging Maps the Localization of Skyrin, the Precursor of Hypericin, and Pathway Intermediates in Leaves of
Topics: Anthracenes; Anthraquinones; Hypericum; Metabolic Networks and Pathways; Molecular Structure; Perylene; Phytochemicals; Plant Leaves; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2020 |
Elucidation the binding interaction of hypericin-loaded P84 copolymeric micelles by using 1D and 2D NMR techniques.
Topics: Anthracenes; Micelles; Perylene; Photochemotherapy | 2022 |
Hypericin, a medicinal compound from St. John's Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells.
Topics: Anthracenes; DNA Damage; Hypericum; Mutagens; Perylene; Plant Extracts | 2022 |
Transcriptome analysis evinces anti-neoplastic mechanisms of hypericin: A study on U87 glioblastoma cell line.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Perylene; Prognosis; Survival Rate; Transcriptome; Tumor Cells, Cultured | 2021 |
Nanoencapsulated hypericin in P-123 associated with photodynamic therapy for the treatment of dermatophytosis.
Topics: Animals; Anthracenes; Capsules; Mice; Nanostructures; Perylene; Photochemotherapy; Photosensitizing Agents; Poloxamer; Polymerization; Tinea | 2021 |
Hypericin-Loaded Transferrin Nanoparticles Induce PP2A-Regulated BMI1 Degradation in Colorectal Cancer-Specific Chemo-Photodynamic Therapy.
Topics: Anthracenes; Colorectal Neoplasms; Humans; Nanoparticles; Perylene; Photochemotherapy; Tissue Distribution; Transferrin | 2020 |
Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic inhibition assay.
Topics: Anthocyanins; Anthracenes; Antiviral Agents; Binding Sites; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Enzyme Assays; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Perylene; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Quantum Theory; Rutin; SARS-CoV-2; Small Molecule Libraries; Thermodynamics | 2021 |
Plasmid DNA-Based Bioluminescence-Activated System for Photodynamic Therapy in Cancer Treatment.
Topics: Anthracenes; Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Cell Survival; DNA; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Luciferases; Luminescent Measurements; Perylene; Photochemotherapy; Photosensitizing Agents; Plasmids | 2021 |
In vivo study of hypericin-loaded poloxamer-based mucoadhesive in situ gelling liquid crystalline precursor system in a mice model of vulvovaginal candidiasis.
Topics: Adhesives; Animals; Anthracenes; Antifungal Agents; Candida albicans; Candidiasis, Vulvovaginal; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Microscopy, Polarization; Mucous Membrane; Perylene; Poloxamer; Radiation-Sensitizing Agents; Scattering, Small Angle; Swine; Vagina; X-Ray Diffraction | 2021 |
Preparation and validation of cyclodextrin-based excipients for radioiodinated hypericin applied in a targeted cancer radiotherapy.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anthracenes; Cyclodextrins; Excipients; Humans; Neoplasms; Perylene; Solubility; Tissue Distribution | 2021 |
Hypericin-mediated photodynamic therapy inhibits growth of colorectal cancer cells via inducing S phase cell cycle arrest and apoptosis.
Topics: Anthracenes; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; DNA Damage; Down-Regulation; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; S Phase | 2021 |
Physiological and Transcriptomic Analysis Provide Insight into Low Temperature Enhancing Hypericin Biosynthesis in
Topics: Anthracenes; Gene Expression Profiling; Hypericum; Perylene; Temperature; Transcriptome | 2021 |
Hypericin-mediated photodynamic therapy enhances gemcitabine induced Capan-2 cell apoptosis via inhibiting NADPH level.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabine; Humans; NADP; Pancreatic Neoplasms; Perylene; Photochemotherapy; Reactive Oxygen Species | 2022 |
Hypericin-P123-photodynamic therapy in an ex vivo model as an alternative treatment approach for onychomycosis caused by Fusarium spp.
Topics: Anthracenes; Fusarium; Humans; Onychomycosis; Perylene; Photochemotherapy; Photosensitizing Agents | 2021 |
The Effects of Photosensitizing Dyes Fagopyrin and Hypericin on Planktonic Growth and Multicellular Life in Budding Yeast.
Topics: Anthracenes; Apoptosis; Cell Cycle; Cell Survival; Coloring Agents; Fluorescence; Morphogenesis; Perylene; Photosensitizing Agents; Plankton; Quinones; Saccharomycetales | 2021 |
Anti-cancer impact of Hypericin in B-CPAP cells: Extrinsic caspase dependent apoptosis induction and metastasis obstruction.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Survival; Fibroblasts; Humans; Inhibitory Concentration 50; Neoplasm Metastasis; Perylene; Signal Transduction; Thyroid Neoplasms | 2021 |
Alkyl Chain Length in Poly(2-oxazoline)-Based Amphiphilic Gradient Copolymers Regulates the Delivery of Hydrophobic Molecules: A Case of the Biodistribution and the Photodynamic Activity of the Photosensitizer Hypericin.
Topics: Anthracenes; Nanoparticles; Oxazoles; Perylene; Photochemotherapy; Photosensitizing Agents; Polymers; Tissue Distribution | 2021 |
Near-infrared Transillumination and Photodynamic Therapy Using Hypericin in Animal Laryngeal Tumors.
Topics: Animals; Anthracenes; Laryngeal Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Rabbits; Transillumination | 2021 |
Hypericin-loaded oil-in-water nanoemulsion synthesized by ultrasonication process enhances photodynamic therapy efficiency.
Topics: Anthracenes; Apoptosis; Cell Survival; Drug Liberation; Drug Stability; Emulsions; Humans; Light; MCF-7 Cells; Nanostructures; Oils; Perylene; Photochemotherapy; Radiation-Sensitizing Agents; Reactive Oxygen Species; Sonication; Temperature; Water | 2021 |
Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease.
Topics: Alphacoronavirus; Amino Acid Sequence; Animals; Anthracenes; Antiviral Agents; Chlorocebus aethiops; Coronavirus 3C Proteases; Coronavirus Infections; Enzyme Activation; Models, Molecular; Perylene; Porcine epidemic diarrhea virus; Recombinant Proteins; Structure-Activity Relationship; Swine; Swine Diseases; Vero Cells; Virus Replication | 2021 |
Surface tailored zein as a novel delivery system for hypericin: Application in photodynamic therapy.
Topics: Animals; Anthracenes; Liver Neoplasms; Mice; Perylene; Photochemotherapy; Photosensitizing Agents; Spectroscopy, Fourier Transform Infrared; Zein | 2021 |
Thermosensitive liposomes encapsulating hypericin: Characterization and photodynamic efficiency.
Topics: Anthracenes; Hyperthermia, Induced; Liposomes; Perylene; Solubility | 2021 |
Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
Topics: Acetylcholine; Animals; Anthracenes; Cell Line; Cell Survival; Fatigue; Gene Expression Regulation; Hydrogen Peroxide; Hypericum; Male; Mice; Mice, Inbred ICR; Myoblasts; Oxidative Stress; Perylene; Physical Conditioning, Animal; Phytotherapy; Random Allocation; Swimming | 2022 |
Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species.
Topics: Anthracenes; Chromatography, Thin Layer; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Terpenes | 2022 |
A new valid rhabdomyosarcoma spheroid culture model for in vitro evaluation of hypericin-based photodynamic therapy.
Topics: Anthracenes; Cell Line, Tumor; Child; Humans; Perylene; Photochemotherapy; Photosensitizing Agents; Rhabdomyosarcoma; Rhabdomyosarcoma, Embryonal | 2022 |
Regeneration of Phytochemicals by Structure-Driven Organization of Microbial Biosynthetic Steps.
Topics: Anthracenes; Fungi; Hypericum; Molecular Structure; Perylene; Phytochemicals | 2022 |
Monitoring tautomerization of single hypericin molecules in a tunable optical λ/2 microcavity.
Topics: Anthracenes; Density Functional Theory; Perylene; Protons | 2022 |
Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic Therapy.
Topics: Anthracenes; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Drug Carriers; Humans; Light; Microscopy, Confocal; Nanogels; Perylene; Photochemotherapy; Photosensitizing Agents; Rose Bengal; Singlet Oxygen | 2021 |
ROS-responsive dexamethasone micelles normalize the tumor microenvironment enhancing hypericin in cancer photodynamic therapy.
Topics: Anthracenes; Cell Line, Tumor; Dexamethasone; Endothelial Cells; Micelles; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2022 |
The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism.
Topics: Animals; Anthracenes; Depression, Postpartum; Female; Glucocorticoids; Humans; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Perylene; Plant Extracts; Pregnancy; Rats | 2022 |
Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination.
Topics: Anthracenes; Drug Combinations; Herb-Drug Interactions; Humans; Hypericum; Irinotecan; Molecular Docking Simulation; Perylene | 2022 |
Mechanisms of hypericin incorporation to explain the photooxidation outcomes in phospholipid biomembrane models.
Topics: Anthracenes; Cell Membrane; Perylene; Phospholipids; Photosensitizing Agents; Static Electricity; Surface Properties | 2022 |
The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral Activity.
Topics: Animals; Anthracenes; Antiviral Agents; Chlorocebus aethiops; COVID-19 Drug Treatment; Perylene; SARS-CoV-2; Vero Cells | 2022 |
Hypericin nanoparticles for self-illuminated photodynamic cytotoxicity based on bioluminescence resonance energy transfer.
Topics: Anthracenes; Cell Line, Tumor; Energy Transfer; HeLa Cells; Humans; Luciferases, Firefly; Nanoparticles; Perylene; Photochemotherapy; Photosensitizing Agents | 2022 |
Biosynthesis of titanium dioxide nanoparticles using Hypericum perforatum and Origanum vulgare extracts and their main components, hypericin and carvacrol as promising antibacterial agents.
Topics: Anthracenes; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Cymenes; Humans; Hypericum; Nanoparticles; Origanum; Perylene; Plant Extracts; Plant Oils; Staphylococcus aureus; Titanium | 2022 |
Accumulation and penetration behavior of hypericin in glioma tumor spheroids studied by fluorescence microscopy and confocal fluorescence lifetime imaging microscopy.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; Microscopy, Fluorescence; Perylene; Photosensitizing Agents | 2022 |
The promise of hypericin: a tracer for acute myocardial infarction.
Topics: Anthracenes; Humans; Myocardial Infarction; Perylene | 2022 |
Effects of hypericin encapsulated on Pluronic F127 photodynamic therapy against triple negative breast cancer.
Topics: Anthracenes; Humans; Perylene; Photochemotherapy; Poloxamer; Triple Negative Breast Neoplasms | 2022 |
Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer.
Topics: Animals; Anthracenes; Lipids; Mice; Nanocapsules; Perylene; Photochemotherapy; Skin Neoplasms | 2022 |
Thermoresponsive Liposomes for Photo-Triggered Release of Hypericin Cyclodextrin Inclusion Complex for Efficient Antimicrobial Photodynamic Therapy.
Topics: Animals; Anthracenes; Anti-Bacterial Agents; Cyclodextrins; Fibroblasts; Liposomes; Mice; Perylene; Photochemotherapy | 2022 |
Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication.
Topics: Animals; Anthracenes; Antiviral Agents; Chlorocebus aethiops; Endonucleases; Exonucleases; Herpesvirus 1, Human; Perylene; Saccharomycetales; Vero Cells; Virus Replication | 2022 |
Spectroscopy studies of interaction hypericin with an anti-cancer therapy drug doxorubicin.
Topics: Anthracenes; Dimethyl Sulfoxide; Doxorubicin; Humans; Perylene; Spectrometry, Fluorescence | 2022 |
The Japanese quail chorioallantoic membrane as a model to study an amphiphilic gradient copoly(2-oxazoline)s- based drug delivery system for photodynamic diagnosis and therapy research.
Topics: Animals; Chorioallantoic Membrane; Coturnix; Drug Delivery Systems; Perylene; Photochemotherapy; Photosensitizing Agents | 2022 |
Improved Hypericin solubility via β-cyclodextrin complexation: Photochemical and theoretical study for PDT applications.
Topics: beta-Cyclodextrins; Models, Theoretical; Perylene; Photochemotherapy; Photosensitizing Agents; Solubility | 2022 |
On the origin of photodynamic activity of hypericin and its iodine-containing derivatives.
Topics: Anthracenes; Iodides; Iodine; Oxygen; Perylene; Quantum Theory | 2022 |
Replicating endothelial shear stress in organ-on-a-chip for predictive hypericin photodynamic efficiency.
Topics: Anthracenes; Endothelial Cells; Humans; Microphysiological Systems; Perylene; Photochemotherapy; Photosensitizing Agents; Vascular Endothelial Growth Factor A | 2023 |
The potential effect of leptin co-administration on photodynamic damage using quail chorioallantoic membrane model.
Topics: Animals; Chorioallantoic Membrane; Coturnix; Leptin; Perylene; Photochemotherapy; Photosensitizing Agents; Quail | 2023 |
Redistribution of hydrophobic hypericin from nanoporous particles of SBA-15 silica in vitro, in cells and in vivo.
Topics: Anthracenes; Nanopores; Perylene; Photochemotherapy; Photosensitizing Agents; Silicon Dioxide | 2023 |
Advanced theranostic nanoplatforms for hypericin delivery in the cancer treatment.
Topics: Anthracenes; Caco-2 Cells; Humans; Lipids; Neoplasms; Perylene; Photochemotherapy; Polymers; Precision Medicine; Tissue Distribution | 2023 |
Effective transport of aggregated hypericin encapsulated in SBA-15 nanoporous silica particles for photodynamic therapy of cancer cells.
Topics: Anthracenes; Nanopores; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Silicon Dioxide | 2023 |