Page last updated: 2024-09-04

hyoscyamine and zileuton

hyoscyamine has been researched along with zileuton in 2 studies

Compound Research Comparison

Studies (hyoscyamine)	Trials (hyoscyamine)	Recent Studies (post-2010) (hyoscyamine)	Studies (zileuton)	Trials (zileuton)	Recent Studies (post-2010) (zileuton)
99	1	55	551	64	193

Protein Interaction Comparison

Protein	Taxonomy	zileuton (IC50)
Prostaglandin E synthase	Homo sapiens (human)	0.6
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	1.4782
Polyunsaturated fatty acid 5-lipoxygenase	Rattus norvegicus (Norway rat)	0.9656
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (human)	0.4
Arachidonate 5-lipoxygenase-activating protein	Homo sapiens (human)	0.58
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	0.591
Polyunsaturated fatty acid 5-lipoxygenase	Mus musculus (house mouse)	0.19
Leukotriene B4 receptor 1	Homo sapiens (human)	0.42
Cysteinyl leukotriene receptor 2	Homo sapiens (human)	0.42
Cysteinyl leukotriene receptor 1	Homo sapiens (human)	0.42

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1

Other Studies

2 other study(ies) available for hyoscyamine and zileuton

Article	Year
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012

Article

Year

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012