hyoscyamine has been researched along with scopolamine hydrobromide in 42 studies
| Studies (hyoscyamine) | Trials (hyoscyamine) | Recent Studies (post-2010) (hyoscyamine) | Studies (scopolamine hydrobromide) | Trials (scopolamine hydrobromide) | Recent Studies (post-2010) (scopolamine hydrobromide) |
|---|---|---|---|---|---|
| 99 | 1 | 55 | 7,548 | 563 | 1,401 |
| Protein | Taxonomy | hyoscyamine (IC50) | scopolamine hydrobromide (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.003 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.006 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.0006 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0026 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 20 (47.62) | 24.3611 |
| 2020's | 8 (19.05) | 2.80 |
| Authors | Studies |
|---|---|
| Aceto, MD; Archer, S; Atkinson, ER; Harris, LS; Luduena, FP; McRitchie, DD; Pearl, J; Shoer, LF | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bermudez, M; Holzgrabe, U; Klöckner, J; Kostenis, E; Mohr, K; Schmitz, J; Schrage, R; Tränkle, C; van der Mey, D; Wolber, G | 1 |
| BRADLEY, PB; ELKES, J | 1 |
| FLUCK, H; NISOLI, A | 1 |
| BUCHS, J | 1 |
| DOBKIN, AB; WYANT, GM | 1 |
| HUEBER, EF; THALER, H | 1 |
| DE BRUYN, JW; VAN HALL, JG | 1 |
| TEITEL, A | 1 |
| UNDERHILL, EW; YOUNGKEN, HW | 1 |
| SEILER, N; WERNER, G | 1 |
| BUECHI, J; ZIMMERMANN, A | 1 |
| BUCKETT, WR; HAINING, CG | 1 |
| AGREN, A; SCHILL, G | 1 |
| ROBERTS, M; TRAUTNER, EM | 1 |
| Lan, XZ; Liao, ZH; Long, SP; Lu, Y; Wang, YX; Yang, CX | 1 |
| Bahrami, AR; Covello, PS; Dehghan, E; Ghotbi Ravandi, E; Reed, DW; Shahriari Ahmadi, F | 1 |
| Li, JD; Liao, ZH; Qiang, W; Wang, YX; Wu, NB; Xia, K; Zhang, QZ | 1 |
| Mulder, PP; Nivarlet, N; van Egmond, HP; von Holst, C | 1 |
| Hagels, H; Krähmer, A; Kurtze, L; Naumann, A; Schulz, H | 1 |
| Cao, YD; He, YC; Kai, GY; Li, H; Xu, JH; Yu, HL | 1 |
| Dziomba, S; Jaremicz, Z; Kowalski, P; Prahl, A; Łepek, T; Łuczkiewicz, M | 1 |
| Hou, YL; Li, X; Liao, ZH; Qiang, W; Xia, K | 1 |
| Delannoy, Y; Hédouin, V; Le Garff, E; Mesli, V; Tournel, G | 1 |
| Averesch, NJ; Castellanos, L; Choi, YH; Kayser, O; Rothauer, A; Ullrich, SF | 1 |
| He, L; Li, P; Song, HP; Wang, H; Wu, SQ; Yang, H; Zhao, X; Zhong, H | 1 |
| Hagels, H; Kayser, O; Kohnen, KL; Sezgin, S; Spiteller, M | 1 |
| Guo, S; Liao, ZH; Liu, X; Lu, KH; Wei, Y; Wu, NB; Yang, Y; Zhang, CP | 1 |
| Aschner, M; Jiménez, J; Jiménez, JA; Kwakye, GF | 1 |
| Guo, S; Liu, X; Wu, NB; Yang, Y | 1 |
| Chen, M; Lan, XZ; Li, X; Liao, ZH; Liu, XQ; Qiang, W; Qiu, F | 1 |
| Chen, M; Lan, XZ; Liao, ZH; Quan, H; Xia, K; Zeng, JL | 1 |
| Liu, X; Wei, Y; Wu, NB; Yang, Y; Zhang, CP | 1 |
| Dai, HH; He, X; Shan, YS; Wu, NB; Xin, ZQ; Yang, Y | 1 |
| Ahmad, P; Kamili, AN; Majeed, U; Sajjad, N; Shah, D; Wani, AA; Wani, ZA | 1 |
| Smolke, CD; Srinivasan, P | 1 |
| Cassereau, J; Courdavault, V; Papon, N | 1 |
| Chen, M; Lan, X; Liang, M; Liao, Z; Lin, M; Qiang, W; Qin, J; Yang, C; Zeng, J; Zhang, Q | 1 |
| Chen, M; Gou, Y; Lan, X; Liao, Z; Qiu, F; Su, F; Sun, X; Tang, Y; Wang, S; Wang, W; Xu, Z; Xue, Z; Yang, C; Zeng, J; Zeng, L; Zhang, F; Zhao, T; Zhou, J | 1 |
| Cardillo, AB; Copello, GJ; Minoia, JM; Rodríguez Talou, J; Villanueva, ME | 1 |
| Cai, Y; Deng, H; Hu, X; Liu, W; Yan, Y | 1 |
3 review(s) available for hyoscyamine and scopolamine hydrobromide
| Article | Year |
|---|---|
Atropa belladonna neurotoxicity: Implications to neurological disorders.
Topics: Animals; Atropa belladonna; Atropine; Humans; Hyoscyamine; Models, Animal; Nervous System Diseases; Plants, Toxic; Polymorphism, Genetic; Scopolamine; Toxicokinetics | 2018 |
Engineered Microbes for Producing Anticholinergics.
Topics: Cholinergic Antagonists; Duboisia; Humans; Hyoscyamine; Molecular Structure; Scopolamine | 2021 |
Tropinone reductase: A comprehensive review on its role as the key enzyme in tropane alkaloids biosynthesis.
Topics: Amino Acid Sequence; Hyoscyamine; Scopolamine; Tropanes | 2023 |
39 other study(ies) available for hyoscyamine and scopolamine hydrobromide
| Article | Year |
|---|---|
Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates.
Topics: Animals; Glycolates; Male; Mice; Motor Activity; Mydriatics; Parasympatholytics; Stereoisomerism; Structure-Activity Relationship; Time Factors; Tremorine; Tropanes | 1977 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity.
Topics: Allosteric Regulation; Animals; Atropine Derivatives; Binding Sites; CHO Cells; Cricetulus; Drug Inverse Agonism; Humans; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Muscarinic Agonists; Muscarinic Antagonists; Mutation; Naphthalimides; Phthalimides; Radioligand Assay; Receptor, Muscarinic M2; Scopolamine Derivatives; Stereoisomerism; Structure-Activity Relationship | 2014 |
The effect of atropine, hyoscyamine, physostigmine and neostigmine on the electrical activity of the brain of the conscious cat.
Topics: Animals; Atropine; Brain; Cats; Cerebral Cortex; Hyoscyamine; Neostigmine; Physostigmine; Scopolamine | 1953 |
[Influence of manure, of the suppression of flowers and fruits, and of the distance between plants on the alkaloid content and on the scopolamine/hyoscyamine ratio in Datura innoxia Miller].
Topics: Alkaloids; Datura; Flowers; Fruit; Hyoscyamine; Manure; Scopolamine | 1954 |
[Hyoscyamine-scopolamine relation in commercial samples of drugs containing tropane alkaloids, paper chromatographic determination].
Topics: Alkaloids; Belladonna Alkaloids; Chromatography, Paper; Hyoscyamine; Scopolamine; Tropanes | 1956 |
Antisialogogue drugs in man; comparison of atropine, scopolamine (1-hyoscine) and 1-hyoscyamine (bellafoline).
Topics: Atropine; Belladonna Alkaloids; Humans; Hyoscyamine; Male; Salivary Glands; Scopolamine | 1957 |
[Studies of new type of drugs with depot-action. I. Use of a hyoscyamine preparation in spastic disorders of the gastrointestinal tract].
Topics: Barbiturates; Belladonna Alkaloids; Gastrointestinal Diseases; Humans; Hyoscyamine; Muscle Spasticity; Scopolamine | 1958 |
[Determination of small quantities of hyoscyamine & hyoscine in medicinal plants].
Topics: Belladonna Alkaloids; Hyoscyamine; Plants, Medicinal; Scopolamine | 1959 |
The cholinergic action of hyoscyamine.
Topics: Acetylcholine; Cholinergic Agents; Hyoscyamine; Neuromuscular Junction; Scopolamine | 1961 |
Biosynthesis of hyoscyamine and scopolamine in Datura stramonium.
Topics: Alkaloids; Atropa belladonna; Datura stramonium; Hyoscyamine; Parasympatholytics; Scopolamine | 1962 |
[AN ENZYMATIC METHOD FOR DETERMINING THE RATE OF RACEMIZATION OF HYOSCYAMINE AND SCOPOLAMINE].
Topics: Alkaloids; Animals; Atropa belladonna; Chemistry, Pharmaceutical; Esterases; Gastrointestinal Agents; Hydrolases; Hyoscyamine; Parasympatholytics; Rabbits; Research; Scopolamine | 1965 |
[STUDY ON THE SEPARATE DETERMINATION OF ATROPINE, HYOSCYAMINE AND SCOPOLAMINE WITH PAPER AND THIN-LAYER CHROMATOGRAPHY. 1].
Topics: Alkaloids; Atropa belladonna; Atropine; Chromatography; Chromatography, Thin Layer; Hyoscyamine; Muscarinic Antagonists; Parasympatholytics; Research; Scopolamine | 1965 |
SOME PHARMACOLOGICAL STUDIES ON THE OPTICALLY ACTIVE ISOMERS OF HYOSCINE AND HYOSCYAMINE.
Topics: Acetylcholine; Animals; Atropa belladonna; Avoidance Learning; Behavior, Animal; Eye; Hyoscyamine; Ileum; Mice; Muscle, Smooth; Muscles; Parasympathomimetics; Pharmacology; Pupil; Rats; Research; Scopolamine; Toxicology; Tranquilizing Agents; Tremor | 1965 |
Separation of hyoscyamine and scopolamine.
Topics: Hyoscyamine; Hyoscyamus; Scopolamine | 1952 |
The separation of hyoscine and hyoscyamine and the alkaloidal assay of Duboisia spp.
Topics: Alkaloids; Biological Assay; Duboisia; Humans; Hyoscyamine; Scopolamine | 1948 |
[Enhancement of tropane alkaloids production in transgenic hair roots of Atropa belladonna by overexpressing endogenous genes AbPMT and AbH6H].
Topics: Atropa belladonna; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hyoscyamine; Methyltransferases; Mixed Function Oxygenases; Plant Roots; Plants, Genetically Modified; Plants, Medicinal; Scopolamine; Synthetic Biology; Tropanes | 2013 |
An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis.
Topics: Alcohol Oxidoreductases; Biological Transport; DNA, Complementary; Gene Expression; Genes, Plant; Hyoscyamine; Hyoscyamus; Iran; Metabolic Networks and Pathways; Methyltransferases; Mixed Function Oxygenases; Plant Proteins; Plant Structures; Plants, Medicinal; Scopolamine; Transcriptome | 2013 |
[Expression pattern of genes involved in tropane alkaloids biosynthesis and tropane alkaloids accumulation in Atropa belladonna].
Topics: Alkaloids; Atropa belladonna; Gene Expression Regulation, Plant; Hyoscyamine; Plants, Medicinal; Scopolamine; Tropanes | 2014 |
Intra- and inter-laboratory validation of a dipstick immunoassay for the detection of tropane alkaloids hyoscyamine and scopolamine in animal feed.
Topics: Animal Feed; Animals; Atropa; Cattle; Datura stramonium; European Union; False Negative Reactions; False Positive Reactions; Food Contamination; Hyoscyamine; Immunoassay; Scopolamine; Seeds | 2014 |
Discrimination of Solanaceae taxa and quantification of scopolamine and hyoscyamine by ATR-FTIR spectroscopy.
Topics: Algorithms; Calibration; Cluster Analysis; Hyoscyamine; Least-Squares Analysis; Plant Leaves; Scopolamine; Solanaceae; Spectroscopy, Fourier Transform Infrared | 2014 |
Efficient biosynthesis of rare natural product scopolamine using E. coli cells expressing a S14P/K97A mutant of hyoscyamine 6β-hydroxylase AaH6H.
Topics: Biocatalysis; Biological Products; Bioreactors; Biotransformation; Escherichia coli; Hydroxylation; Hyoscyamine; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Mutant Proteins; Scopolamine; Solanaceae; Solanaceous Alkaloids; Substrate Specificity | 2015 |
Simultaneous determination of scopolamine, hyoscyamine and anisodamine in in vitro growth media of selected Solanaceae hairy roots by CE method.
Topics: Culture Media; Electrophoresis, Capillary; Hyoscyamine; In Vitro Techniques; Plant Roots; Scopolamine; Solanaceae; Solanaceous Alkaloids | 2015 |
[Cloning and expression of the key enzyme hyoscyamine 6 beta-hydroxylase gene (DaH6H) in scopolamine biosynthesis of Datura arborea].
Topics: Cloning, Molecular; Datura; DNA, Complementary; Escherichia coli; Hyoscyamine; Mixed Function Oxygenases; Plant Leaves; Plant Roots; Recombinant Proteins; Scopolamine | 2015 |
Forensic features of a fatal Datura poisoning case during a robbery.
Topics: Adult; Anticholinergic Syndrome; Atropine; Datura; Forensic Toxicology; Homicide; Humans; Hyoscyamine; Male; Scopolamine; Vitreous Body | 2016 |
Discrimination of wild types and hybrids of Duboisia myoporoides and Duboisia leichhardtii at different growth stages using
Topics: Alkaloids; Chromatography, High Pressure Liquid; Duboisia; Hyoscyamine; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Scopolamine; Tropanes | 2016 |
Label-free pharmacological profiling based on dynamic mass redistribution for characterization and authentication of hazardous natural products.
Topics: Animals; Biological Products; Biosensing Techniques; Cell Line; CHO Cells; Chromatography, High Pressure Liquid; Cricetulus; Datura; Hazardous Substances; Humans; Hyoscyamine; Molecular Docking Simulation; Proof of Concept Study; Receptor, Muscarinic M2; Scopolamine | 2017 |
Localization and Organization of Scopolamine Biosynthesis in Duboisia myoporoides R. Br.
Topics: Alkaloids; Atropine Derivatives; Biosynthetic Pathways; Duboisia; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Hyoscyamine; Mixed Function Oxygenases; Plant Leaves; Plant Roots; Plants, Medicinal; Scopolamine; Solanaceous Alkaloids; Tropanes | 2018 |
[Effects of nitrogen form on accumulation of alkaloids and expression of relative genes in Atropa belladonna].
Topics: Atropa belladonna; Gene Expression Regulation, Plant; Hyoscyamine; Mixed Function Oxygenases; Nitrogen; Scopolamine | 2018 |
[Mechanism exploration on nitrogen metabolism and secondary metabolism in Atropa belladonna hairy roots treated with yeast extract].
Topics: Atropa belladonna; Hyoscyamine; Nitrogen; Plant Roots; Plants, Genetically Modified; Scopolamine; Secondary Metabolism | 2018 |
[Cloning and characterization of an aromatic amino acid aminotransferase(ArAT) gene involved in tropane alkaloid biosynthesis from Hyoscyamus niger].
Topics: Alkaloids; Atropa belladonna; Biosynthetic Pathways; Cholinergic Antagonists; Cloning, Molecular; Hyoscyamine; Hyoscyamus; Plant Proteins; Plant Roots; Scopolamine; Solanaceous Alkaloids; Transaminases; Tropanes | 2017 |
[Overexpression of NtPMT and HnH6H changed hyoscyamine-rich Atropa belladonna to scopolamine-rich varieties].
Topics: Alkaloids; Atropa belladonna; Cholinergic Antagonists; Gene Expression Regulation, Plant; Hyoscyamine; Mixed Function Oxygenases; Plants, Genetically Modified; Scopolamine; Tropanes | 2016 |
[Effects of methyl jasmonate on metabolism of topical alkaloids and expression of relate genes in Atropa belladonna].
Topics: Acetates; Atropa belladonna; Cyclopentanes; Gene Expression Regulation, Plant; Hyoscyamine; Oxylipins; Plant Leaves; Plant Roots; Scopolamine | 2018 |
[Nitrogen metabolism and secondary metabolism regulation of Atropa belladonna by exogenous NO under NaCl stress].
Topics: Atropa belladonna; Hyoscyamine; Nitrogen; Nitroprusside; Scopolamine; Secondary Metabolism; Sodium Chloride; Stress, Physiological | 2020 |
Promoting the accumulation of scopolamine and hyoscyamine in Hyoscyamus niger L. through EMS based mutagenesis.
Topics: Biosynthetic Pathways; Ethyl Methanesulfonate; Gene Expression Regulation, Plant; Hyoscyamine; Hyoscyamus; Methyltransferases; Mixed Function Oxygenases; Mutagenesis; Mutagens; Mutation; Plants, Genetically Modified; Scopolamine | 2020 |
Biosynthesis of medicinal tropane alkaloids in yeast.
Topics: Acyltransferases; Alkaloids; Animals; Atropa belladonna; Atropine Derivatives; Biological Transport; Datura; Glucosides; Hyoscyamine; Lactates; Ligases; Models, Molecular; Nervous System Diseases; Oxidoreductases; Protein Engineering; Saccharomyces cerevisiae; Scopolamine; Vacuoles | 2020 |
Engineering tropane alkaloid production and glyphosate resistance by overexpressing AbCaM1 and G2-EPSPS in Atropa belladonna.
Topics: Atropa belladonna; Gene Expression Regulation, Plant; Glycine; Glyphosate; Hyoscyamine; Plants, Genetically Modified; Scopolamine; Tropanes | 2022 |
Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family.
Topics: Alkaloids; Atropa belladonna; Hyoscyamine; Scopolamine; Solanaceae; Tropanes | 2023 |
Recycling of hyoscyamine 6β-hydroxylase for the in vitro production of anisodamine and scopolamine.
Topics: Escherichia coli; Glutaral; Hyoscyamine; Scopolamine | 2023 |