Page last updated: 2024-09-04

hyoscyamine and amlodipine

hyoscyamine has been researched along with amlodipine in 2 studies

Compound Research Comparison

Studies (hyoscyamine)	Trials (hyoscyamine)	Recent Studies (post-2010) (hyoscyamine)	Studies (amlodipine)	Trials (amlodipine)	Recent Studies (post-2010) (amlodipine)
99	1	55	4,200	1,504	1,671

Protein Interaction Comparison

Protein	Taxonomy	amlodipine (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus (domestic guinea pig)	1.2
Potassium channel subfamily K member 2	Homo sapiens (human)	0.4
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.602
Alpha-2C adrenergic receptor	Homo sapiens (human)	1.8
5-hydroxytryptamine receptor 6	Homo sapiens (human)	2.898
Sodium-dependent dopamine transporter	Homo sapiens (human)	5.521
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	2.7
Potassium channel subfamily K member 2	Bos taurus (cattle)	0.43

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1

Other Studies

2 other study(ies) available for hyoscyamine and amlodipine

Article	Year
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012

Article

Year

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012