hymecromone and gamma-fagarine

Herbs are often administered in combination with therapeutic drugs, raising the possibility for herb-drug interactions (HDIs). Furoquinoline alkaloids are found in Rutaceae plants, which are structurally similar and have many medicinal properties. This study aims to investigate the inhibition of four furoquinoline alkaloids on the activity of UDP-glucuronosyltransferases (UGTs).The recombinant UGTs-catalyzed glucuronidation metabolism of 4-methylumbelliferone (4-MU) was utilized to investigate the inhibition potential. Inhibition type and parameters were determined, and

Topics: Alkaloids; Computer Simulation; Enzyme Inhibitors; Glucuronosyltransferase; Herb-Drug Interactions; Humans; Hymecromone; Molecular Docking Simulation; Quinolines