hymecromone and fosbretabulin

hymecromone has been researched along with fosbretabulin* in 1 studies

Other Studies

1 other study(ies) available for hymecromone and fosbretabulin

Article	Year
Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages. Angewandte Chemie (International ed. in English), 2015, Nov-09, Volume: 54, Issue:46 Despite significant progress in the clinical application of antibody drug conjugates (ADCs), novel cleavage strategies that provide improved selectivity are still needed. Herein is reported the first approach that uses near-IR light to cleave a small molecule from a biomacromolecule, and its application to the problem of ADC linkage. The preparation of cyanine antibody conjugates, drug cleavage mediated by 690 nm light, and initial in vitro and in vivo evaluation is described. These studies provide the critical chemical underpinning from which to develop this near-IR light cleavable linker strategy. Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Carbocyanines; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Hymecromone; Infrared Rays; MCF-7 Cells; Mice; Neoplasms, Experimental; Panitumumab; Photolysis; Stilbenes; Structure-Activity Relationship	2015

Article

Year

Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages.

Angewandte Chemie (International ed. in English), 2015, Nov-09, Volume: 54, Issue:46

Despite significant progress in the clinical application of antibody drug conjugates (ADCs), novel cleavage strategies that provide improved selectivity are still needed. Herein is reported the first approach that uses near-IR light to cleave a small molecule from a biomacromolecule, and its application to the problem of ADC linkage. The preparation of cyanine antibody conjugates, drug cleavage mediated by 690 nm light, and initial in vitro and in vivo evaluation is described. These studies provide the critical chemical underpinning from which to develop this near-IR light cleavable linker strategy.

Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Carbocyanines; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Hymecromone; Infrared Rays; MCF-7 Cells; Mice; Neoplasms, Experimental; Panitumumab; Photolysis; Stilbenes; Structure-Activity Relationship

2015