hymecromone and dixanthogen

Studies on the induction of non-oxygenative detoxication enzymes in mice by anticarcinogenic thionosulfur compounds have been extended to include hepatic and pulmonary UDP-glucuronosyltransferases. Dietary administration of disulfiram and of bisethylxanthogen to female CD-1 mice enhanced microsomal glucuronidation of 4-methylumbelliferone, a characteristic GT1 substrate, and of 4-hydroxybiphenyl, a GT2 substrate. Latency of the activity toward 4-methylumbelliferone was not affected appreciably. Disulfiram also enhanced glucuronidation of 4-nitrophenol. Diethyldithiocarbamate was ineffective under the conditions used. These thionosulfur compounds caused no significant change in beta-glucuronidase activity measured in homogenates of 7 organs.

Topics: Animals; Biphenyl Compounds; Diet; Disulfides; Disulfiram; Ditiocarb; Female; Glucuronates; Glucuronidase; Glucuronosyltransferase; Hymecromone; Lung; Mice; Microsomes; Microsomes, Liver; Nitrophenols; Thiones