hymecromone and coumachlor

hymecromone has been researched along with coumachlor* in 1 studies

Other Studies

1 other study(ies) available for hymecromone and coumachlor

ArticleYear
Synthesis, physicochemical characterization, and cytotoxic screening of new zirconium complexes with coumarin derivatives.
    Archiv der Pharmazie, 2001, Volume: 334, Issue:5

    Zirconium complexes of mendiaxon, warfarin, coumachlor, and niffcoumar have been synthesized by reaction of the ligands with zirconium chloride in stoichiometric ratio 1:2. The formation of the complexes has been proved on the basis of elemental analysis, IR-spectroscopy, 1H-NMR spectroscopy, and thermal studies. Differential thermal analyses and thermogravimetric analyses have been applied to study the compositions of the new complexes. It is concluded that the lactone- and the keto-carbonyl groups of warfarin, coumachlor, and niffcoumar are bonded to the metal ion as bidentate ligands, but mendiaxon is bonded as monodentate ligand. Cytotoxic screening by MTT-assay was carried out. Among these compounds the zirconium complex of mendiaxon showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. The inorganic salt was found to be active against this cell line.

    Topics: Antineoplastic Agents; Cell Survival; Coumarins; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hymecromone; Ligands; Magnetic Resonance Spectroscopy; Organometallic Compounds; Spectrophotometry, Infrared; Warfarin; Zirconium

2001