hydroxyurea and valproic acid

hydroxyurea has been researched along with valproic acid in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (3.03)	18.2507
2000's	10 (30.30)	29.6817
2010's	19 (57.58)	24.3611
2020's	3 (9.09)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cappellacci, L; D'Alessandro, N; Del Bello, F; Ferro, A; Franchetti, P; Grifantini, M; Hofer, A; Jayaram, HN; Kusumanchi, P; Meli, M; Petrelli, R; Tolomeo, M; Torquati, I; Vita, P; Vodnala, M	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Basran, RK; Chang, L; Nisbet-Brown, E; Olivieri, NF; Selby, R	1
Heinzel, T; Knauer, SK; Krämer, OH; Stauber, RH; Zimmermann, D	1
Darras, BT; Kang, PB	1
Coleman, MD; Hill, EJ; Prince, M; Woehrling, EK	1
Butchbach, ME; Lorson, CL; Mattis, VB	1
Bönnemann, CG; Finkel, RS	1
Lieberman, PM; Snyder, AR; Zhou, J	1
Espinoza, JL; Kondo, Y; Lu, X; Nakao, S; Ohata, K; Qi, Z	1
Bruserud, Ø; Fredly, H; Gjertsen, BT; Stapnes Bjørnsen, C	1
Alías, L; Also-Rallo, E; Baiget, M; Barceló, MJ; Bernal, S; Caselles, L; Martínez-Hernández, R; Tizzano, EF	1
Bosboom, WM; Iannaccone, ST; van den Berg, LH; Vrancken, AF; Wadman, RI; Wokke, JH	1
Bosboom, WM; Iannaccone, ST; van den Berg, LH; van der Pol, WL; Vrancken, AF; Wadman, RI; Wokke, JH	1
Darras, BT; Liew, WK; Singh, P	1
Andresen, V; Bruserud, Ø; Gjertsen, BT; Kristiansen, S; Leitch, C; McCormack, E; Molland, M; Nguyen, XN; Osdal, T	1
Balleari, E; Bernal, T; Beyne-Rauzy, O; Bordessoule, D; Calabuig, M; Cametti, G; Campelo, MD; Cheze, S; Cony-Makhoul, P; Dreyfus, F; Fenaux, P; Fensterl, J; Ferrero, D; Gaidano, G; Germing, U; Gioia, D; Götze, K; Guerci-Bresler, A; Hamel, JF; Kaivers, J; Kelaidi, C; Komrokji, R; Kotsianidis, I; Müller-Thomas, C; Pane, F; Park, S; Ramos, F; Roboz, GJ; Rose, C; Sanna, A; Santini, V; Sanz, GF; Sapena, R; Sekeres, MA; Stamatoullas, A; Steensma, DP; Thépot, S; Toma, A; Vey, N; Wattel, E	1
Cai, Z; Feng, Z; Guo, G; Liu, G; Luo, Y; Powell, S; Tian, Y; Tian, Z; Wang, H; Wang, S; Wang, X; Zhang, F	1
Bruserud, Ø; Fredly, HK; Gjertsen, BT; Grønningsæter, IS; Hatfield, KJ	1
Brenner, W; Butter, F; Kiweler, N; Krämer, OH; Mahendrarajah, N; Schneider, G; Stauber, RH; Wirth, M; Wünsch, D	1
Guan, Z; Li, S; Liang, Y; Niu, B; Wang, J; Wang, X; Yang, A; Yu, J; Zhu, Z	1

Reviews

5 review(s) available for hydroxyurea and valproic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical trials in spinal muscular atrophy. Current opinion in pediatrics, 2007, Volume: 19, Issue:6 Topics: Animals; Child; Clinical Trials as Topic; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Humans; Hydroxyurea; Infant; Motor Neurons; Nerve Tissue Proteins; Nucleic Acid Synthesis Inhibitors; Phenylbutyrates; RNA-Binding Proteins; SMN Complex Proteins; Spinal Muscular Atrophies of Childhood; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein; Valproic Acid	2007
Drug treatment for spinal muscular atrophy types II and III. The Cochrane database of systematic reviews, 2011, Dec-07, Issue:12 Topics: Acetylcarnitine; Adolescent; Amines; Child; Child, Preschool; Creatine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydroxyurea; Neuroprotective Agents; Phenylbutyrates; Randomized Controlled Trials as Topic; Spinal Muscular Atrophies of Childhood; Thyrotropin-Releasing Hormone; Valproic Acid	2011
Drug treatment for spinal muscular atrophy types II and III. The Cochrane database of systematic reviews, 2012, Apr-18, Issue:4 Topics: Acetylcarnitine; Adolescent; Amines; Child; Child, Preschool; Creatine; Cyclohexanecarboxylic Acids; Disease Progression; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydroxyurea; Neuroprotective Agents; Phenylbutyrates; Randomized Controlled Trials as Topic; Spinal Muscular Atrophies of Childhood; Thyrotropin-Releasing Hormone; Valproic Acid	2012
Current advances in drug development in spinal muscular atrophy. Current opinion in pediatrics, 2013, Volume: 25, Issue:6 Topics: Animals; Child; Child, Preschool; Disease Models, Animal; Drug Design; Female; Genetic Therapy; Humans; Hydroxyurea; Male; Mice; Muscular Atrophy, Spinal; Mutation; Nerve Tissue Proteins; Neuroprotective Agents; Stem Cell Transplantation; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein; Valproic Acid	2013

Other Studies

28 other study(ies) available for hydroxyurea and valproic acid

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. Bioorganic & medicinal chemistry letters, 2014, Nov-15, Volume: 24, Issue:22 Topics: Adenosine; Adenosine Triphosphate; Allosteric Regulation; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Esters; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Kinetics; Ribonucleotide Reductases; Valproic Acid	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Valproic acid and augmentation of fetal hemoglobin in individuals with and without sickle cell disease. Blood, 1997, Jul-15, Volume: 90, Issue:2 Topics: Anemia, Sickle Cell; Anticonvulsants; Antisickling Agents; Blood Transfusion; Carbamazepine; Child; Fetal Hemoglobin; Follow-Up Studies; Hemoglobins; Humans; Hydroxyurea; Seizures; Valproic Acid	1997
Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. Oncogene, 2008, Jan-31, Volume: 27, Issue:6 Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxyurea; Melanoma; Ribonucleotide Reductases; Valproic Acid	2008
Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing. Toxicology, 2008, Jul-30, Volume: 249, Issue:2-3 Topics: Acrylamides; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Densitometry; Gene Expression; Humans; Hydroxyurea; Image Processing, Computer-Assisted; Immunohistochemistry; Lithium Chloride; Microscopy, Confocal; Models, Neurological; Nervous System Diseases; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Teratogens; Tretinoin; Valproic Acid	2008
Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy. Journal of neuroscience methods, 2008, Oct-30, Volume: 175, Issue:1 Topics: Alternative Splicing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Epitope Mapping; Fibroblasts; Gene Expression Regulation; Humans; Hydroxyurea; Indoles; Mice; Mice, Transgenic; Muscular Atrophy, Spinal; SMN Complex Proteins; Spinal Cord; Survival of Motor Neuron 2 Protein; Valproic Acid	2008
Linking SMN to SMA: an assay for the rescuer. Neurology, 2008, Nov-25, Volume: 71, Issue:22 Topics: Cell Survival; Central Nervous System Agents; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyurea; Motor Neurons; Muscular Atrophy, Spinal; Phenylbutyrates; Protein Splicing; Research Support as Topic; Survival of Motor Neuron 1 Protein; Transcription, Genetic; Valproic Acid	2008
Epstein-Barr virus episome stability is coupled to a delay in replication timing. Journal of virology, 2009, Volume: 83, Issue:5 Topics: Binding Sites; DNA Replication; DNA, Viral; Genome, Viral; Genomic Instability; HeLa Cells; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxyurea; Plasmids; Protein Binding; Replication Origin; Telomere-Binding Proteins; Valproic Acid; Virus Replication	2009
Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis. Cancer science, 2010, Volume: 101, Issue:3 Topics: Caffeine; Cell Line, Tumor; Cytotoxicity, Immunologic; Drug Synergism; Gene Expression Regulation, Leukemic; GPI-Linked Proteins; Humans; Hydroxyurea; Intercellular Signaling Peptides and Proteins; Killer Cells, Natural; Leukemia, Myeloid; Up-Regulation; Valproic Acid	2010
Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia--a report of five cases. Hematology (Amsterdam, Netherlands), 2010, Volume: 15, Issue:5 Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Histone Deacetylase Inhibitors; Humans; Hydroxyurea; Leukemia, Myeloid; Male; Mercaptopurine; Middle Aged; Treatment Outcome; Valproic Acid	2010
Treatment of spinal muscular atrophy cells with drugs that upregulate SMN expression reveals inter- and intra-patient variability. European journal of human genetics : EJHG, 2011, Volume: 19, Issue:10 Topics: Cell Line, Transformed; Cells, Cultured; Drug Resistance; Female; Fibroblasts; Frameshift Mutation; Gene Dosage; Gene Expression Regulation; Humans; Hydroxyurea; Lymphocytes; Male; Muscular Atrophy, Spinal; Phenylbutyrates; Siblings; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein; Treatment Outcome; Up-Regulation; Valproic Acid	2011
Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia. Oncotarget, 2016, Feb-16, Volume: 7, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants; Antineoplastic Agents; Apoptosis; Blotting, Western; Case-Control Studies; Cell Proliferation; Drug Synergism; Female; Fluorescent Antibody Technique; Follow-Up Studies; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Mutation; Neoplasm Staging; Prognosis; Survival Rate; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Valproic Acid; Xenograft Model Antitumor Assays	2016
Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, May-10, Volume: 35, Issue:14 Topics: Aged; Aged, 80 and over; Anemia; Antilymphocyte Serum; Antineoplastic Agents; Arsenic; Azacitidine; Chromosome Deletion; Chromosomes, Human, Pair 5; Cyclosporine; Cytarabine; Decitabine; Disease Progression; Enzyme Inhibitors; Erythrocyte Transfusion; Female; Hematinics; Humans; Hydroxyurea; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Recurrence; Retreatment; Retrospective Studies; Risk Factors; Survival Rate; Thalidomide; Treatment Failure; Tretinoin; Valproic Acid	2017
Valproic acid sensitizes breast cancer cells to hydroxyurea through inhibiting RPA2 hyperphosphorylation-mediated DNA repair pathway. DNA repair, 2017, Volume: 58 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; DNA; DNA Breaks, Double-Stranded; DNA Replication; Female; Humans; Hydroxyurea; Rad51 Recombinase; Rats; Recombinational DNA Repair; Replication Protein A; Valproic Acid	2017
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy. Cells, 2019, 10-10, Volume: 8, Issue:10 Topics: Aged; Aged, 80 and over; Amino Acids; Cytarabine; Drug Therapy; Female; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Lipid Metabolism; Male; Mercaptopurine; Metabolomics; Middle Aged; Treatment Outcome; Tretinoin; Valproic Acid	2019
Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes. Journal of cancer research and clinical oncology, 2020, Volume: 146, Issue:2 Topics: Animals; Benzamides; Cell Plasticity; Cisplatin; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Humans; Hydroxyurea; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasms; Pyridines; Transforming Growth Factor beta; Valproic Acid	2020
Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis. Neurochemical research, 2022, Volume: 47, Issue:12 Topics: Animals; Anticonvulsants; Antineoplastic Agents; Class I Phosphatidylinositol 3-Kinases; ErbB Receptors; Female; Fluorouracil; Hydroxyurea; Methotrexate; Mice; Molecular Docking Simulation; Network Pharmacology; Neural Tube Defects; Phosphatidylinositol 3-Kinases; Pregnancy; Tretinoin; Valproic Acid	2022