hydroxyurea and tyrosine

hydroxyurea has been researched along with tyrosine in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (16.67)	18.7374
1990's	15 (41.67)	18.2507
2000's	10 (27.78)	29.6817
2010's	5 (13.89)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andersson, LC; Autero, M; Mustelin, T; Oetken, C; Ruutu, T; von Willebrand, M	1
Langen, P; Lassmann, G; Liermann, B	1
Chan, AK; Engstrom, Y; McClarty, GA; Thelander, L; Wright, JA	1
Reichard, P	1
Akerblom, L; Ehrenberg, A; Gräslund, A; Lankinen, H; Reichard, P; Thelander, L	1
Ehrenberg, A; Gräslund, A; Sahlin, M; Sjöberg, BM	1
Barlow, T; Eliasson, R; Platz, A; Reichard, P; Sjöberg, BM	1
Ehrenberg, A; Reichard, P	1
Rieber, M; Rieber, MS	1
Aquino, MA; Han, JY; Lam, KY; Swarts, JC; Sykes, AG	1
Asada, K; Chen, GX; Kawamoto, K; Mano, J	1
Gräslund, A; Nyholm, S; Thelander, L	1
Covès, J; Eschenbrenner, M; Fontecave, M; Nivière, V	1
Curtis, J; Eling, TE; Lassmann, G; Liermann, B; Mason, RP	1
Fincher, RR; O'Donnell, K; Osmani, SA; Tang, A; Ye, XS	1
Eklund, H; Kauppi, B; Larsen, IK; Nielsen, BB; Ramaswamy, S; Thelander, L; Thelander, M	1
Baldacci, G; Bouvier, D; Francesconi, S; Grenon, M	1
Eklund, H; Elleingand, E; Fontecave, M; Gerez, C; Kauppi, B	1
Rhind, N; Russell, P	1
Enoch, T; Forbes, KC; Humphrey, T	1
Murakami, H; Nurse, P	1
Frank, DA; Gesbert, F; Griffin, JD; Sattler, M; Sillaber, C	1
Kunkel, TA; Pavlov, YI; Shcherbakova, PV	1
Coffey, MJ; Peters-Golden, M; Phare, SM	1
Hochhaus, A; Lahaye, T; Müller, MC	1
Loeb, LA; Sneeden, JL	1
Moriyama, A; Murakami, H; Nakanishi, M; Sugimoto, I; Tonami, Y	1
Bilio, AJ; Lien, EJ; Ren, S; Shao, J; Shih, J; Su, L; Yen, Y; Yuan, YC; Zhou, B; Zhu, L	1
Biglino, D; Gräslund, A; Sahlin, M; Sjöberg, BM; Torrents, E	1
Bildirici, U; Celikyurt, U; Ural, E	1
Barry, BA; Offenbacher, AR; Seyedsayamdost, MR; Stubbe, J; Vassiliev, IR	1
Lin, X; Liu, Y; Ni, Z; Wan, X; Yang, X; Zhang, L; Zhang, Z	1
An, X; Huang, M; Liu, L; Stubbe, J; Wu, X; Zhang, Y	1
Winnicki, K	1
Barry, BA; Minnihan, EC; Offenbacher, AR; Stubbe, J	1
Blanco, L; Blanco-Franco, L; Calvo, PA; Díaz, M; Díaz-Talavera, A; González-Acosta, D; Guerra, S; Martínez-Jiménez, MI; Méndez, J; Sastre-Moreno, G	1

Other Studies

36 other study(ies) available for hydroxyurea and tyrosine

Article	Year
Phenylarsine oxide augments tyrosine phosphorylation in hematopoietic cells. European journal of haematology, 1992, Volume: 49, Issue:4 Topics: Aged; Animals; Arsenicals; Blood Platelets; Busulfan; Cell Line; Dithiothreitol; Gene Rearrangement; Granulocytes; Humans; Hydroxyurea; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine	1992
Quenching of tyrosine radicals of M2 subunit from ribonucleotide reductase in tumor cells by different antitumor agents: an EPR study. Free radical biology & medicine, 1990, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Hydroxyurea; Mammary Neoplasms, Experimental; Mice; Pyrogallol; Ribonucleotide Reductases; Thiosemicarbazones; Tumor Cells, Cultured; Tyrosine	1990
Elevated expression of M1 and M2 components and drug-induced posttranscriptional modulation of ribonucleotide reductase in a hydroxyurea-resistant mouse cell line. Biochemistry, 1987, Dec-01, Volume: 26, Issue:24 Topics: Animals; Cell Line; Cell Nucleus; Drug Resistance; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxyurea; Macromolecular Substances; Mice; Mutation; Nucleic Acid Hybridization; Ribonucleotide Reductases; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Tyrosine	1987
Control of deoxyribonucleotide synthesis in vitro and in vivo. Advances in enzyme regulation, 1972, Volume: 10 Topics: Adenosine Triphosphate; Animals; Binding Sites; Catalysis; Cell Line; Cells, Cultured; Cricetinae; Cytosine; Deoxyribonucleotides; DNA; Escherichia coli; Guanosine Triphosphate; Hydroxyurea; Macromolecular Substances; Mice; Models, Chemical; Nucleosides; Oxidoreductases; Time Factors; Tyrosine	1972
Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells. Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:4 Topics: Animals; Cell Line; Deoxyribonucleotides; Drug Resistance; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxyurea; Macromolecular Substances; Mice; Ribonucleotide Reductases; Tyrosine	1981
Structure of the tyrosyl radical in bacteriophage T4-induced ribonucleotide reductase. The Journal of biological chemistry, 1982, Jan-10, Volume: 257, Issue:1 Topics: Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radicals; Hydroxyurea; Ribonucleotide Reductases; T-Phages; Tyrosine	1982
Enzymic modification of a tyrosine residue to a stable free radical in ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:6 Topics: Apoproteins; Binding Sites; Electron Spin Resonance Spectroscopy; Enzyme Activation; Escherichia coli; Free Radicals; Hydroxyurea; Iron; Macromolecular Substances; Ribonucleotide Reductases; Structure-Activity Relationship; Tyrosine	1983
Ribonucleotide reductase--a radical enzyme. Science (New York, N.Y.), 1983, Aug-05, Volume: 221, Issue:4610 Topics: Animals; Deoxyribonucleotides; DNA; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radicals; Hydroxyurea; Iron; Oxidation-Reduction; Ribonucleotide Reductases; Ribonucleotides; Tyrosine	1983
Cyclin-dependent kinase 2 and cyclin A interaction with E2F are targets for tyrosine induction of B16 melanoma terminal differentiation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1994, Volume: 5, Issue:12 Topics: Animals; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Differentiation; Cell Line; Culture Media; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; DNA, Neoplasm; E2F Transcription Factors; Hydroxyurea; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Protein Serine-Threonine Kinases; Retinoblastoma-Binding Protein 1; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured; Tyrosine	1994
Kinetic studies on the reduction of the tyrosyl radical of the R2 subunit of E. coli ribonucleotide reductase. Biochimica et biophysica acta, 1995, Mar-15, Volume: 1247, Issue:2 Topics: Buffers; Catechols; Escherichia coli; Free Radicals; Glutamates; Hydrogen-Ion Concentration; Hydroxamic Acids; Hydroxylamines; Hydroxyurea; Kinetics; Oxidation-Reduction; Ribonucleotide Reductases; Thermodynamics; Tyrosine	1995
Photoinactivation of photosystem II by in situ-photoproduced hydroxyurea radicals. Biochemistry, 1994, Aug-30, Volume: 33, Issue:34 Topics: Binding Sites; Free Radicals; Hydroxyurea; Kinetics; Light-Harvesting Protein Complexes; Oxidation-Reduction; Oxygen; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Tyrosine; Vegetables; Water	1994
Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea. Biochemistry, 1993, Nov-02, Volume: 32, Issue:43 Topics: Animals; Escherichia coli; Hydroxyurea; Iron; Mice; Oxidation-Reduction; Recombinant Proteins; Ribonucleotide Reductases; Spectrum Analysis; Tyrosine	1993
NADPH-sulfite reductase from Escherichia coli. A flavin reductase participating in the generation of the free radical of ribonucleotide reductase. The Journal of biological chemistry, 1993, Sep-05, Volume: 268, Issue:25 Topics: Amino Acid Sequence; Blotting, Western; Catalysis; Electron Transport; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; FMN Reductase; Free Radicals; Hydroxyurea; Molecular Sequence Data; Molecular Weight; Mutation; NADH, NADPH Oxidoreductases; NADP; Oxidoreductases Acting on Sulfur Group Donors; Ribonucleotide Reductases; Sulfite Reductase (NADPH); Tyrosine	1993
ESR studies on reactivity of protein-derived tyrosyl radicals formed by prostaglandin H synthase and ribonucleotide reductase. Archives of biochemistry and biophysics, 1993, Volume: 300, Issue:1 Topics: Animals; Anisoles; Carcinoma, Ehrlich Tumor; Cyclooxygenase Inhibitors; Electron Spin Resonance Spectroscopy; Eugenol; Free Radicals; Hydroxyurea; Indoleacetic Acids; Indomethacin; Kinetics; Male; Mice; Prostaglandin-Endoperoxide Synthases; Ribonucleotide Reductases; Seminal Vesicles; Sheep; Tyrosine	1993
Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis. The EMBO journal, 1996, Jul-15, Volume: 15, Issue:14 Topics: Aspergillus nidulans; Base Sequence; CDC2 Protein Kinase; Cell Cycle Proteins; DNA; DNA Primers; Fungal Proteins; Hydroxyurea; Mitosis; Molecular Sequence Data; Mutation; NIMA-Related Kinase 1; NIMA-Related Kinases; Phosphorylation; Protein Serine-Threonine Kinases; S Phase; Signal Transduction; Tyrosine	1996
The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2. Journal of molecular biology, 1996, Oct-11, Volume: 262, Issue:5 Topics: Animals; Bacterial Proteins; Crystallography, X-Ray; Escherichia coli; Free Radical Scavengers; Hydroxyurea; Iron; Mice; Models, Molecular; Oxidation-Reduction; Protein Conformation; Protein Structure, Secondary; Ribonucleotide Reductases; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine	1996
p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast. The EMBO journal, 1997, Mar-17, Volume: 16, Issue:6 Topics: Checkpoint Kinase 1; DNA Damage; DNA Replication; Hydroxyurea; Mutation; Phenotype; Phosphorylation; Protein Kinases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Temperature; Tyrosine	1997
Reactivity of the tyrosyl radical of Escherichia coli ribonucleotide reductase -- control by the protein. European journal of biochemistry, 1997, Oct-15, Volume: 249, Issue:2 Topics: Amino Acid Substitution; Ascorbic Acid; Binding Sites; Crystallography, X-Ray; Dithionite; Escherichia coli; Free Radical Scavengers; Free Radicals; Hydrazines; Hydroxyurea; Kinetics; Leucine; Models, Structural; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenols; Phenylalanine; Protein Conformation; Recombinant Proteins; Ribonucleotide Reductases; Substrate Specificity; Tyrosine	1997
Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe. Molecular and cellular biology, 1998, Volume: 18, Issue:7 Topics: CDC2 Protein Kinase; Cell Cycle; DNA Replication; DNA, Fungal; Hydroxyurea; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Schizosaccharomyces; Signal Transduction; Tyrosine	1998
Suppressors of cdc25p overexpression identify two pathways that influence the G2/M checkpoint in fission yeast. Genetics, 1998, Volume: 150, Issue:4 Topics: Amino Acid Sequence; Base Sequence; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Helicases; DNA Replication; DNA, Fungal; Fungal Proteins; G2 Phase; Gene Expression Regulation, Fungal; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Mitosis; Molecular Sequence Data; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; ras-GRF1; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Signal Transduction; Transcription, Genetic; Tyrosine	1998
Meiotic DNA replication checkpoint control in fission yeast. Genes & development, 1999, Oct-01, Volume: 13, Issue:19 Topics: CDC2 Protein Kinase; Cell Nucleus; DNA Replication; DNA, Fungal; Hydroxyurea; Meiosis; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Schizosaccharomyces; Signal Transduction; Tyrosine	1999
STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood, 2000, Mar-15, Volume: 95, Issue:6 Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Cell Cycle; Cell Division; Cell Line; Cell Line, Transformed; Cell Survival; Cytarabine; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Doxycycline; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genes, Reporter; Hydroxyurea; Mice; Milk Proteins; Mutation; Phosphorylation; Promoter Regions, Genetic; STAT5 Transcription Factor; Time Factors; Trans-Activators; Tyrosine	2000
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta. Genetics, 2001, Volume: 159, Issue:1 Topics: Alanine; Alleles; Amino Acid Motifs; Amino Acid Sequence; Base Pair Mismatch; Binding Sites; Catalysis; Conserved Sequence; Diploidy; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Primers; DNA Repair; DNA-Directed DNA Polymerase; Dose-Response Relationship, Radiation; Frameshift Mutation; Heterozygote; Homozygote; Hydroxyurea; Methyl Methanesulfonate; Models, Genetic; Molecular Sequence Data; Mutation; Phenotype; Plasmids; Point Mutation; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Tyrosine; Ultraviolet Rays	2001
Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1 Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitrates; omega-N-Methylarginine; Precipitin Tests; Proteins; Rats; Rats, Wistar; Tyrosine	2001
[Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells]. Deutsche medizinische Wochenschrift (1946), 2002, Oct-18, Volume: 127, Issue:42 Topics: Amino Acid Substitution; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Clone Cells; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Histidine; Humans; Hydroxyurea; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mercaptopurine; Middle Aged; Oncogene Proteins, Fusion; Piperazines; Point Mutation; Pyrimidines; Selection, Genetic; Tyrosine	2002
Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea. The Journal of biological chemistry, 2004, Sep-24, Volume: 279, Issue:39 Topics: Antineoplastic Agents; Blotting, Western; Cloning, Molecular; Crystallography, X-Ray; Dimerization; DNA; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Escherichia coli; Gene Library; Genetic Complementation Test; Hydroxyurea; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Conformation; Protein Structure, Tertiary; Ribonucleotide Reductases; Time Factors; Tyrosine	2004
DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. The Journal of biological chemistry, 2004, Nov-05, Volume: 279, Issue:45 Topics: Carrier Proteins; Cell Cycle Proteins; Checkpoint Kinase 2; Culture Media; DNA; DNA Replication; DNA, Fungal; Flow Cytometry; Green Fluorescent Proteins; Hydroxyurea; Immunoblotting; Immunoprecipitation; Indoles; Mad2 Proteins; Methyl Methanesulfonate; Mitosis; Mutagens; Mutation; Nuclear Proteins; Phenotype; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Spindle Apparatus; Temperature; Time Factors; Tyrosine; Ultraviolet Rays	2004
Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay. Biochemical pharmacology, 2005, Feb-15, Volume: 69, Issue:4 Topics: Dimethyl Sulfoxide; Enzyme Inhibitors; Holoenzymes; Humans; Hydroxyurea; KB Cells; Protein Subunits; Recombinant Proteins; Ribonucleotide Reductases; Schiff Bases; Tyrosine	2005
Efficient growth inhibition of Bacillus anthracis by knocking out the ribonucleotide reductase tyrosyl radical. Proceedings of the National Academy of Sciences of the United States of America, 2005, Dec-13, Volume: 102, Issue:50 Topics: Amino Acid Sequence; Bacillus anthracis; Bacterial Proteins; Base Sequence; Cell Proliferation; Cloning, Molecular; Cluster Analysis; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radical Scavengers; Hydroxylamines; Hydroxyurea; Molecular Sequence Data; Ribonucleotide Reductases; Sequence Alignment; Sequence Analysis, DNA; Spectrum Analysis; Survival Analysis; Tyrosine	2005
Essential thrombocythemia: a case of acute ST-segment elevation myocardial infarction in a young female. Clinical cardiology, 2009, Volume: 32, Issue:2 Topics: Adult; Age Factors; Antisickling Agents; Aspirin; Clopidogrel; Coronary Angiography; Female; Fibrinolytic Agents; Heparin; Humans; Hydroxyurea; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombocythemia, Essential; Ticlopidine; Tirofiban; Tissue Plasminogen Activator; Tyrosine	2009
Redox-linked structural changes in ribonucleotide reductase. Journal of the American Chemical Society, 2009, Jun-10, Volume: 131, Issue:22 Topics: Hydroxyurea; Models, Molecular; Oxidation-Reduction; Protein Conformation; Ribonucleotide Reductases; Spectroscopy, Fourier Transform Infrared; Static Electricity; Tyrosine	2009
Non-ST-segment elevation myocardial infarction in a patient with essential thrombocythemia treated with glycoprotein IIb/IIIa inhibitor: a case report. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2011, Volume: 17, Issue:5 Topics: Electrocardiography; Enzyme Inhibitors; Humans; Hydroxyurea; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombocytopenia; Thrombosis; Tirofiban; Tyrosine	2011
Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. The Journal of biological chemistry, 2011, Dec-02, Volume: 286, Issue:48 Topics: Glutaredoxins; Hydroxyurea; Iron; Iron-Sulfur Proteins; Mutation; Oxidoreductases; Ribonucleoside Diphosphate Reductase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spheroplasts; Tyrosine	2011
ATM/ATR-dependent Tyr15 phosphorylation of cyclin-dependent kinases in response to hydroxyurea in Vicia faba root meristem cells. Protoplasma, 2013, Volume: 250, Issue:5 Topics: Amino Acid Sequence; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cyclin-Dependent Kinases; DNA Damage; G1 Phase; Hydroxyurea; Meristem; Molecular Sequence Data; Phosphorylation; Plant Proteins; Proteasome Endopeptidase Complex; S Phase; Tyrosine; Vicia faba	2013
Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase β2. Journal of the American Chemical Society, 2013, May-01, Volume: 135, Issue:17 Topics: Antineoplastic Agents; Aspartic Acid; Escherichia coli; Ferric Compounds; Hydrogen Bonding; Hydroxyurea; Ligands; Models, Molecular; Oxidation-Reduction; Oxygen; Protons; Ribonucleotide Reductases; Spectroscopy, Fourier Transform Infrared; Tyrosine	2013
A cancer-associated point mutation disables the steric gate of human PrimPol. Scientific reports, 2019, 02-04, Volume: 9, Issue:1 Topics: Animals; Cell Cycle; Cell Line; Computer Simulation; DNA Primase; DNA-Directed DNA Polymerase; Drug Resistance; Histidine; Humans; Hydroxyurea; Mice; Models, Molecular; Multifunctional Enzymes; Neoplasms; Nucleotides; Point Mutation; Tyrosine	2019