Compounds > hydroxyurea

hydroxyurea and thiophenes

hydroxyurea has been researched along with thiophenes in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's5 (62.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rainsford, KD; Smith, F; Ying, C1
Bell, RL; Bhatia, PA; Bouska, JB; Brooks, CD; Carter, GW; Craig, RA; DeNinno, SL; Holms, JH; Kerdesky, FA; Kolasa, T; Lanni, C; Maki, RG; Martin, JG; Martin, MB; Mazdiyasni, H; Moore, JL; Ratajczyk, JD; Rodriques, KE; Stewart, AO; Summers, JB; Young, PR1
Machinist, JM; Mayer, MD; Roberts, EM; Rodrigues, AD; Surber, BW1
Chordia, MD; Heasley, BH; Joshi, EM; Macdonald, TL1
Agamennone, M; Biasone, A; Campestre, C; Consalvi, V; Gallina, C; Gavuzzo, E; Hiller, O; Mazza, F; Pochetti, G; Preziuso, S; Tortorella, P; Tschesche, H1
Chandrasekaran, A; Jordan, R; Li, H; Markiewicz, V; Scatina, J; Shen, L; Tong, Z; Xiang, Q1
Chordia, MD; Li, F; Macdonald, TL; Woodling, KA1
Heasley, BH; Joshi, EM; Macdonald, TL1

Other Studies

8 other study(ies) available for hydroxyurea and thiophenes

ArticleYear
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:1

    Topics: Animals; Benzofurans; Enzyme-Linked Immunosorbent Assay; Hip Joint; Humans; Hydroxyurea; Indoles; Interleukin-1; Knee Joint; Lipoxygenase Inhibitors; Naphthalenes; Organ Culture Techniques; Oxindoles; Pyrazoles; Quinolines; Structure-Activity Relationship; Swine; Synovial Membrane; Tarsus, Animal; Thiazoles; Thiophenes

1996
Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.
    Journal of medicinal chemistry, 1997, Jun-20, Volume: 40, Issue:13

    Topics: Animals; Cells, Cultured; Drug Design; Enzyme Inhibitors; Furans; Glucuronates; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Macaca fascicularis; Models, Chemical; Rats; Structure-Activity Relationship; Templates, Genetic; Thiophenes

1997
Identification of the human liver cytochrome P450 enzymes involved in the in vitro metabolism of a novel 5-lipoxygenase inhibitor.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:10

    Topics: Catalysis; Cytochrome P-450 Enzyme System; DNA, Complementary; Fluorobenzenes; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Microsomes, Liver; Thiophenes

1998
In vitro metabolism of 2-acetylbenzothiophene: relevance to zileuton hepatotoxicity.
    Chemical research in toxicology, 2004, Volume: 17, Issue:2

    Topics: Animals; Cell Line; Glutathione; Half-Life; Humans; Hydroxyurea; Liver; Magnetic Resonance Spectroscopy; Rats; Spectrometry, Mass, Electrospray Ionization; Thiophenes

2004
N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8.
    Bioorganic & medicinal chemistry letters, 2006, Jan-01, Volume: 16, Issue:1

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Humans; Hydrogen-Ion Concentration; Hydroxyurea; Inhibitory Concentration 50; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Models, Chemical; Models, Molecular; Oxygen; Phenylalanine; Protein Binding; Protein Conformation; Thiophenes; Zinc

2006
Effects of ertiprotafib on hepatic cytochrome P450 and peroxisomal enzymes in rats and dogs, and in rat and human primary hepatocytes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:1

    Topics: Animals; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Female; Glucuronosyltransferase; Hepatocytes; Humans; Hydroxyurea; Hypoglycemic Agents; Liver; Male; Microsomes, Liver; Organ Size; Peroxisomes; Phenylpropionates; Rats; RNA, Messenger; Thiazolidinediones; Thiophenes; Thyroid Gland

2007
Irreversible alkylation of human serum albumin by zileuton metabolite 2-acetylbenzothiophene-S-oxide: a potential model for hepatotoxicity.
    Chemical research in toxicology, 2007, Volume: 20, Issue:12

    Topics: Alkylation; Anti-Asthmatic Agents; Binding, Competitive; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Half-Life; Humans; Hydroxyurea; Ibuprofen; Models, Biological; Serum Albumin; Tandem Mass Spectrometry; Thiophenes; Warfarin

2007
2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: implications for toxicity associated with zileuton.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:3

    Topics: Chromatography, Liquid; Glutathione Transferase; Hydroxyurea; Inactivation, Metabolic; Isoenzymes; Kinetics; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Thiophenes; Toxicity Tests

2009